Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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DAVID Functional Annotation Table
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cadherin 1(CDH1) cadherin 1(CDH1) Related Genes Homo sapiens
CHROMOSOME 16,
CYTOBAND 16q22.1,
ENSEMBL_GENE_ID ENSG00000039068,
GENERIF_SUMMARY Products of the c-myc gene activate or repress the activity of the E-cadherin promoter, Both expression of E-cadherin and its membranous localization are required for well-differentiated-type morphogenesis in gallbladder cancer cells., Mutations and polymorphisms in E-cadherin gene CDH1, such as S270A, may contribute to the onset of prostate cancer (PCA) and warrant further investigations in other populations., The E-cadherin gene was potentially inactivated in a significant number of synovial sarcomas., Loss of E-cadherin may result in the disruption of the function of the cell-cell adhesion complex, which may cause weak cell-cell adhesion and confer invasive properties on a tumor., Cadherin-mediated cell sorting not determined by binding or adhesion specificity, restoration of E-cadherin dependent adhsion in human protate carcinoma cells by expression of receptor protein-tyrosine phosphatase, PTPmu, E-cadherin might be used as additional cell markers of Schwann cell-derived tumors., distinct methylation pattern in bladder cancer with frequent methylation of RARbeta, DAPK, E-cadherin, and p16., D257A & D370A mutations result in abnormal protein localization, changes in the actin cytoskeleton, reduced homophilic cell adhesion, and altered cell morphology; tumor-associated D370A mutation, but not the D257A mutation, induced increased cell motility, biological function of Cys(9) within the first repeat (the E-cadherin-derived N-terminal repeat), These results demonstrate that integrin-dependent cell to extracellular matrix adhesion reinforces E-cadherin-dependent cell-cell adhesion in Caco-2 cells., E-cadherin play important roles in esophageal carcinogenesis., The SLUG zinc-finger protein represses E-cadherin in breast cancer., Lateral dimerization of the E-cadherin extracellular domain is necessary but not sufficient for adhesive activity, results suggest that the inadequate trophoblastic invasion, induced by antiphospholipid antibodies, can be the result of decreased alpha1 integrin and VE-cadherin and increased alpha5 integrin and E-cadherin expression in the trophoblast, characterization of DNA polymorphism in promoter regions, mucoepidermoid carcinoma of the thyroid (MECT)displays consistent neoexpression of P-cadherin and major alterations in the expression of E-cadherin and the three catenins, Tumor-associated mutations of E-cadherin enhanced random cell movement of transfected MDA-MB-435S mammary carcinoma cells as compared to wild-type (wt) E-cadherin-expressing cells., restoration of cell adhesion by overexpression of nectin in HSC-39 cells, Differential expression in human brain tumors, E-cadherin expression in dental epithelium followed an apical-coronal gradient that was opposite to that observed for N-cadherin., CAS/CSE 1 stimulates E-cadhrin-dependent cell polarity in HT-29 human colon epithelial cells., promoter methylation studied in 80 patients with head and neck squamous cell carcinoma (HNSCC), role in regulating expression of the leucocyte common antigen-related tyrosine phosphatase, Recovery of cellular E-cadherin precedes replenishment of estrogen receptor and estrogen-dependent proliferation of breast cancer cells rescued from a death stimulus., aberrant methylation preferentially occurs in invasive ductal breast cancer associated with poor prognosis and is one of the mechanisms of expression silence in breast cancers, Src-induced disruption of E-cadherin localization requires specific integrin signalling., Data suggest that E-cadherin-mediated signaling through PI3-kinase can regulate the invasive behavior of cells by modulating proteinase secretion., Defected E-cadherin expression might play a role in the development of malignant phenotype in NSCLC, ZEB1 plays a role in repressing E-cadherin and MUC1 in epithelial cells [ZEB-1], oxidative stress induces tyrosine phosphorylation and cellular redistribution of occludin-ZO-1 and E-cadherin-beta-catenin complexes by a tyrosine-kinase-dependent mechanism, Downregulation of E-cadherin in melanocytes and melanoma cells by endothelin-1, Altered expression of E-cadherin in hepatocellular carcinoma, CpG hypermethylation was an important mechanism of E-cadherin gene inactivation in bladder cancer and also that specific CpG sites consistently presented higher methylation levels than others., E-cadherin promoter is subject to epigenetic control in colorectal ulceration and plays a role in the progression from chronic inflammation to colorectal cancer., E-cadherin polymorphism in prostate neoplasms, CDH1 c-160a promotor polymorphism is not associated with risk of stomach cancer., germline E-cadherin mutations responsible for the predisposition to diffuse gastric cancer (DGC) among the Japanese, Restoration of E-cadherin/beta-catenin expression in pancreatic cancer cells inhibits growth by induction of apoptosis., dimerization of E-cadherin is important for its cell adhesive properties, In vivo recruitment of RB and AP-2 proteins on the E-cadherin promoter in MCF7 cells, investigates whether E-cadherin is a substrate for calpain and whether calpain-dependent proteolysis was associated with prostate cancer progression, E-cadherin is hypermethylated and shows low expression in colon and rectal neoplasms, results indicate that expression of E-cadherin in IST-1 trophoblast cells results in a contact-mediated inhibition of motility and invasion and suggest an important role for E-cadherin down-regulation in the intermediate trophoblast during implantation, in vivo evidence in cancer cells of the differential association between CpG methylation, MBPs, and histone modification in the entire CpG island of the human E-cadherin (CDH1) gene, Involvement of the adhesive ligand pair CD103-E-cadherin in human thymocyte cell proliferation, These data reveal a cooperative interaction between p120 catenin and E-cadherin and a novel role for p120 that is likely indispensable in normal cells., association of CDH1 haplotypes with susceptibility to sporadic diffuse gastric cancer, clinical significance of E-cadherin and proliferating cell nuclear antigen expression in adenoid cystic carcinoma, The reduction of E-cadherin and beta-catenin expression was related to invasiveness and proliferative status of prolactinomas and correlated with the more aggressive behavior of prolactinomas in men compared with in women., role in negative regulation of CD44-hyaluronan interaction, promotion of E-cadherin and suppression of beta-catenin/T cell factor may be an important mechanism underlying the chemopreventive action of Ca(2+) in colon cancer, Loss of E-cadherin expression followed by expression of the mts1 gene may be an important event for increasing cell proliferation, motility and invasion activity in the progression of gallbladder cancer., The presence of E-cadherin mutations can significantly alter the accumulation of the apoptosis-regulating p53 protein, whereas no correlation with the p53 mutation status or with Ki-67 staining was observed., Expression of e-cadherin and beta-catenin in human esophageal squamous cell carcinoma, Abnormal E-cadherin and alpha-catenin and beta-catenin in pancreatic carcinoma tissues. Abnormal E-cadherin and alpha-catenin with differentiation, lymph node and liver metastases. Aberrant beta-catenin with lymph node and liver metastases., phosphorylation-dependent localization of CDH1 in vertebrate cells., CpG methylation and thus loss of E-cadherin is associated with metastasising laryngeal cancer., matrix metalloproteinase-2 and 9 and membrane-type 1 matrix metalloproteinase mRNA expression in endometriosis was higher than in normal endometrium whereas E-cadherin, alpha- and beta-catenin mRNA expression was not suppressed in endometriosis, Pulse-labeled beta-catenin replaces the beta-catenin bound to the cell surface prebiotinylated E-cadherin immediately after synthesis or arrives at the plasma membrane in a complex with the E-cadherin precursor., Hypermethylation of an E-cadherin (CDH1) promoter region in high grade transitional cell carcinoma of the bladder comprising carcinoma in situ., study verified reduced expressions of adenomatous polyposis coli and E-cadherin proteins in colorectal cancer cells and suggests that normal protein expressions in benign epithelium are progressively and independently lost in sporadic colorectal cancers, possibility that multiple pathways exist for E-cadherin entry into cells that are likely to reflect cell context and regulation., decreased expression of the E-cadherin catenin complex and methylation of the E-cadherin gene promoter region was found only in growth hormone cell adenomas with prominent fibrous bodies, E-cadherin and claudins/occludin have roles in the regulation of tight junctions during the epithelium-mesenchyme transition, but are repressed by snail, The molecular requirements for E-cadherin to activate Rac signaling thus appear distinct from those that stimulate PI3-kinase, and we postulate that p120-ctn may play a central role in the E-cadherin-Rac signaling pathway., Abnormal expression of E-cadherin was seen in mucoepidermoid carcinoma., High expression of E-cadherin is associated with the development of lymphatic tumor emboli, dedifferentiation and a decreased expression of E-cadherin and ZO-1 are closely related to liver metastasis, polymorphism of CDH-1 3'-UTR is a valid genetic marker for calcium stone disease., Findings identify E-cadherin as a novel substrate for matrilysin and indicate that shedding of E-cadherin ectodomain is required for epithelial repair., E-cadherin A/A genotype may be associated with susceptibility to urothelial cancer, but not with the progression of disease., The loss of E-cadherin rather than beta-catenin mutation is the crucial event in determining the differentiation 'level' of thyroid carcinomas, Findings document the differential expression, subcellular localization and cell-cycle-regulatory activity of alternatively spliced human CDH1 isoforms., CDH1 inactivation due to mutations, LOH and methylation is associated with invasive and in situ lobular breast cancer., E-cadherin inhibits human mammary and prostate tumor cell invasion. The invasion suppressor signal is mediated through the beta-catenin-binding domain of the E-cadherin cytoplasmic tail., Methyl-CpG-binding protein 2 and promoter methylation cooperatively regulate E-cadherin gene expression in colorectal carcinoma, In nasopharyngeal cancer, methylation of promoter is a major cause of down-regulation of E-cadherin which may finally lead to detachment and metastasis of neoplastic cells., Single nucleotide polymorphism in the E-cadherin gene promoter is associated with tumorigenesis and progression of gastric carcinoma, Expression of HPV16 E6 in keratinocyes decreases expression of cell surface E-cadherin thereby depleting langerhans cells at the site of infection, Data demonstrate a direct role of E-cadherin/catenin complex organization in the regulation of matrix metalloproteinases and suggest an implication of this regulation in the expression of an invasive phenotype by bronchial tumor cells., Bcl-2 expression decreases the level of functional E-cadherin thereby interfering with junction formation, Results suggested that human embryos and blastocysts could express E-cadherin and the expression increased during their development., the -160 C/A polymorphism of E-cadherin is not directly involved in Korean gastric cancer development, provides support that E-cadherin induction by WNT/beta-catenin signaling is an evolutionarily conserved pathway operative in lung cancer cells and that loss of expression may be important in lung cancer development or progression, E-cadherin has a role in tumorigenicity and metastasis, Hypoxia induces down-regulation of E-cadherin in ovarian carcinoma cells, via up-regulation of the transcriptional repressor SNAIL., E-cadherin-mediated cell adhesion and apoptosis of prostatic cancer cells are regulated by ligand activation of the androgen receptor, E-cadherin affected the regulation of cell proliferation, differentiation and adhesion, and decreased chemosensitivity, the comparable region of N-cadherin can substitute for this required region in E-cadherin and is required for suppression by the mutant form of N-cadherin that is capable of suppressing, The frequencies of E-cadherin promoter hypermethylation appear to be correlated with more advanced stage of squamous carcinogenesis in skin., A recombinant E-cadherin lacking free sulfhydryl groups and its mutants with novel cysteines were expressed. The coexistence of the structurally identical adhesive and lateral dimers suggests some flexibility of the extracellular cadherin region., Pancreatic cancer likely occurs in case of the inactivation of E-cadherin and alpha-catenin genes and abnormal expression of proteins, We conclude, therefore, that two major components of cell-cell interaction synergistically regulate cell cycle progression in HEK293 cells by regulating p21 expression in a beta-catenin/TCF-dependent manner., Intragenic deletion of CDH1 is the activating mechanism of the wild-type allele in hereditary diffuse gastric carcinoma., In human melanocytic tumors, a causative role of (loss of ) E-cadherin or (gain of ) N-cadherin for melanocytic tumor progression still remains to be proven., E-cadherin and epidermal growth factor receptor (EGFR) are associated in mammary epithelial cells and that E-cadherin engagement in these cells induces transient activation of EGFR, as previously seen in keratinocytes., an 80 kDa fragment of E-cadherin has a role in the metastatic progression of prostate cancer, E-cadherin mediated adhesion and signaling in mammalian epithelial cells requires homolog of disc-large, investigation of whether the -347G-->GA single nucleotide polymorphism affects the transcriptional activity of the E-cadherin gene, Low expression of E-cadherin is associated with late cervical metastasis in stage I and II invasive squamous cell carcinoma of the oral tongue, FAM associates with E-cadherin and beta-catenin during trafficking to the plasma membrane, Aberrant methylation of CDH1 is associated with recurrent cervical cancer, Promoter hypermethylation of E-cadherin and its abnormal expression in Epstein-Barr virus-associated gastric carcinoma, endogenous PGE2 is involved in the hBD-2 and E-cadherin responses of human gingival epithelial cells to A. actinomycetemcomitans. HGEC exposed to A. actinomycetemcomitans showed a decrease in E-cadherin levels., EphA2 and E-cadherin may play an important role in tumor metastasis in colorectal cancer, single nucleotide polymorphism in CDH1 is a low-penetrant prostate cancer susceptibility gene, Cdx1 or Cdx2 expression is sufficient to induce E-cadherin-dependent adhesion of COLO 205 cells associated with polarization and cell-cell membrane compaction, as well as induction of differentiated gene-expression pattern., Combined evaluation of VEGF and E-cadherin levels may become a useful indicator of NSCLC biological behavior and provide clinically important evidence on which to base treatment in NSCLC., E-cadherin plays an important role in regulating the invasive potential of prostate cancer cells through an unique paracrine mechanism., promoter hypermethylation and consequent downregulated of E-cadherin is significantly associated with gastric carcinomas of the diffuse histotype, Results identify a necessary role for cortactin in the cadherin-actin cooperation that supports productive contact formation., E-cadherin-mediated adhesion mechanisms have a role in sperm-oolemma interactions, Snail is involved in both the direct transcriptional repression of genes, such as E-cadherin and occludin, and post-transcriptional events, including downregulation of claudin-1, SH2 and SH3 domains of Src mediate peripheral accumulation of phospho-myosin, leading to integrin adhesion complex assembly, whereas loss of SH2 or SH3 function restores normal regulation of E-cadherin and inhibits vimentin expression, CDH1 methylation and E-cadherin expression are related and have a role in progression of diffuse gastric cancer, E-cadherin has a role in preventing peritoneal dissemination in gastric cancer, The absence of dermal invasion of nevus cells could be due to the expression of E-cadherin in these cells in reconstructed epidermis., E- to N-cadherin switching in epithelial carcinomas has a potential impact on metastatic progression., Cytoplasmic p120ctn may contribute to the invasive phenotype of E-cadherin-deficient breast cancer cells., determination of CDH1 promoter methylation in breast tumors with decreased or absent E-cadherin protein expression, E-cadherin-mediated cell adhesion is required for keratinocyte-mediated control of melanocytic cells, which can override proliferative activity of beta-catenin., E-cadherin -347 G-->GA polymorphism may be associated with colorectal cancer., Thirteen novel CDH1 mutations found in diffuse gastric cancer families., Hypermethylation of CDH1 is statistically significantly associated with poor outcome in cervical cancer., the establishment of E-cadherin-based cell-cell adhesion requires Rap1, E-cadherin and p16INK4a are commonly methylated in non-small cell lung cancer, mutant E-cadherin significantly alters the dynamics of cell adhesion and motility in living cells, Data showed that intestinal metaplasia is associated with E-cadherin down-regulation in gastric mucosa, whereas H. pylori infection does not seem to play a direct role in this process., E-cadherin and calretinin are sensitive and specific in differential diagnosis of benign and malignant serous effusion specimens., abnormal immunhistochemical E-cadherin and beta-catenin expression is associated with changes in pit pattern in invasive colorectal neoplasms, Review summarizes divergent studies that provide evidence of the function of E-cadherin trafficking and the puzzle of how this adhesion molecule is regulated and managed throughout the life of the epithelial cell., E-cadherin mutations have no influence on expression of genes involved in Wnt-signaling, but they may promote their own expression by blocking upregulation of E-cadherin repressors., Most invasive and metastatic areas of oral squamous cell carcinoma showed reduced expression and methylation of E-cadherin., Decreased E-cadherin expression is an independent prognostic factor for disease progression and mortality in pathological stage I-III endometrial cancer., T lymphocyte development can proceed independently of alphaEbeta7/E-cadherin interactions, Laryngeal cancer presented inactivation of Cx43 gene and E-cad gene and down regulation of Cx43 and E-cad proteins., Results point to a functional link between matrix metalloproteinase-3 and E-cadherin, role in tumor genesis and progress of hereditary gastric carcinoma, E-cadherin downregulation is associated with the loss or absence of glandular epithelial differentiation in certain synovial sarcoma, The E-Cadherin, the main system of adherens junction, present in the tight junctions in HepG2 cells., conjoint endocytosis and trafficking is a novel mechanism for the coregulation of E-cadherin and FGFR1 during cell signaling and morphogenesis, the interaction of Pnn with the corepressor CtBP1 may modulate repression of E-cadherin transcription by CtBP1, CDHE expression is repressed in the lower crypt of small intestine and is a biological marker of functional relevance., E-cadherin-deficiency in metastatic cancer may in some cases be due to p120 downregulation [review], E-cadherin may have a role in progression of squamous cell carcinoma, heregulin stimulates aggregation and inhibits invasion of MCF-7/6 cells via activation of the E-cadherin/catenin complex, E-cadherin gene C-160A promoter polymorphism may not play a major role in the etiology of non-cardia gastric cancer in Chinese population., Change in the location of E-cadherin expression (from membrane cytoplasm) is strongly associated with an increased aggressiveness of colrectal cancer., Wnt signaling stabilizes Snail and beta-catenin proteins in tandem fashion so as to cooperatively engage transcriptional programs that control an epithelial-mesenchymal transition., Loss of expression of E-cadherin and beta-catenin may play an important role in the progression of pulmonary adenocarcinoma, Aberrant E-cadherin is result of point mutation in exon 9 donor splice site causing skipping of exon 9 with consequent deletion of corresponding amino acids. Leads to disturbed cell adhesion. Mediates formation of cadherin/ catenin complex., These results provide a new example of Rho GTPase regulation of basolateral trafficking and demonstrate novel roles for Cdc42 and Rac1 in the post-Golgi transport of E-cadherin., a novel pathway for Rab11 dependent, dileucine-mediated, mu1B-independent sorting and basolateral trafficking, exemplified by E-cadherin, Data suggest when carcinoma in a gastric biopsy is negative for E-cadherin staining, metastatic breast carcinoma should be considered., Altered E-cadherin adhesion complex is an early event affecting atypical lobular hyperplasia as well as lobular carcinoma in situ and occurs prior to progression to invasive disease., All 61 meningothelial meningiomas, 10 of 12 invasive meningiomas, and 3 of 5 anaplastic meningiomas were positive for both ECAD and beta-catenin, while these were both negative in all of the fibrous meningiomas., Tumors with reduced E-cadherin expression invaded deeper, had more lymph node metastasis, and had more lymphatic invasion than the tumors with preserved E-cadherin expression., cadherin switching (downregulation of E-cadherin and upregulation of N-cadherin) is necessary for increased motility but is not required for the morphological changes that accompany the epithelium-to-mesenchyme transition, Disruption of E-cadherin-mediated cell-cell contacts at high cell density inhibits the induction of p27(kip1) and restores proliferation in contact-inhibited cells., association between decreased expression and metastatic Wilms' tumor, dysfunction of E-cadherin and nm23 has a role in progression of NSCLC, mutations cause inactivation of the cell adhesion protein E-cadherin; carriers of the CDH1 germline gene mutation develop an aggressive, diffuse, submucosal gastric cancer at an early age [review], E-cadherin expression was significantly associated with higher tumour grade in colorectal carcinoma., These findings suggest that alteration of the E-cadherin pathway can contribute to human clefting., examined here the effect of trans-interacting nectin on non-trans-interacting E-cadherin endocytosis, E-cadherin may play a distinct role in the development of ovarian epithelial cancers., Strong E-cadherin expression in lymph node metastases was highly predictive of improved survival., The entire cadherin-catenin complex is involved when assessing its prognostic value in colonic adenocarcinom., disturbances in the distribution of beta-catenin and E-cadherin might affect the morphology of adenoid cystic carcinoma, ADAM10 has a role in E-cadherin shedding and epithelial cell-cell adhesion, migration, and beta-catenin translocation, Domain 5 of E-cadherin may play a critical role in the regulation of heterophilic adhesion to integrin alphaEbeta7; domains 1, 2, 3, and 4 are involved in homophilic adhesion., expression at transcriptional level is repressed by HBV X protein, SIP1 sumoylation by Pc2 attenuates transcriptional repression of E-cadherin, an E-cadherin germline mutation may have a role in development of hereditary diffuse gastric cancer, E-cadherin distribution in human embryos is stage-dependent, Patients with the -160C/C genotype might require H. pylori infection to promote inactivation of CDH1, suggesting that H. pylori infection might affect gastric carcinomas in initial stage because polymorphism is germ line., Reduced E-cadherin is a common genetic phenotype of gastric cancers and plays beneficial roles in tumor metastasis., upon infection of quiescent cells human cytomegalovirus not only activates the E2F-dependent G(1)/S transcription program but also facilitates protein accumulation of APC/C substrates by rapid Cdh1 dissociation, E-cadherin may have a role in progression and recurrence of transitional cell carcinomas of the urinary bladder, The E-cadherin is a cell-cell adhesion protein expressed in cytotrophoblasts, which is lost as they differentiate and syncytialise., loss of E-cadherin-mediated adhesion plays a causal role in the transition from low- to high-grade squamous cell carcinoma, E-cadherin protein was lost and mRNA levels were significantly decreased in prostate cancer cells expressing kallikrein 4 and prostate specific antigen., report strong confirmation of the association between prostate cancer risk in FH+ cases and a functional CDH1 promoter SNP in an independent population, inhibition of E-cadherin-dependent cell-cell adhesion led to the genetic reprogramming of tumor cells, -160(C-->A) polymorphism in CDH1 gene promoter region may not be in association with genetic susceptibility to gastric cancer in Chinese population from Fujian., The TGFbeta(1)-induced destabilisation of E-cadherin-mediated cell-cell adhesion involves phosphorylation of beta-catenin, which is regulated by E-cadherin adhesion complex-associated PI3-kinase and PTEN., Increased expression of delta-catenin os associated with the down-regulation and redistibution of ECAD and p120ctn in prostatic cancer., Cell-to-cell communication mediated by E-cadherin contributes to the acquirement of a cardiomyogenic phenotype of human endothelial progenitor cells., With tumor progression and development of heterogeneity, the abnormal expressions of MMP-9, TIMP-2, and E-cadherin or DNA aneuploid rate or high SPF gradually increases, suggesting that they play a crucial role in gastric carcinoma progression, Depressed E-cadherin correlates with HBxAg trans-activation function., CDH-1 is closely related to metalloproteinase and plays important but not well-understood role in onset and progression of primary open angle glaucoma. Role could be resolved by posttranslated products of gene and protein-protein interaction., expression of E-cadherin and beta-catenin is significantly down regulated in prostate cancer compared to surrounding benign appearing prostate, which correlates with increasing Gleason grade, The CDH-1 gene 3'-UTR C/T polymorphism is associated with prostate cancer. The 'CC' homozygote indicates a relatively higher risk for developing prostate cancer than other genotypes., In testicular tumours, as in other neoplasms, dysadherin downregulates E-cadherin expression, at least in part, E-cadherin controls enterocyte-specific expression of genes, such as the apoA-IV gene, through the control of hepatic nuclear factor 4alpha nuclear abundance, These results suggest that Scrib stabilizes the coupling between E-cadherin and the catenins and are consistent with the idea that mammalian Scrib could behave as a tumor suppressor by regulating epithelial cell adhesion and migration., transforming growth factor-beta1 overexpression and alteration in E-cadherin/beta-catenin complexes in bladder urothelium might play a crucial role in urinary bladder carcinogenesis in humans exposed to long-term low-dose ionizing radiation, Data indicate that E-cadherin may modulate Wnt-dependent gene expression in DLD-1 colorectal cancer cells by regulating the availability of beta-catenin., CDH1 may be a low-penetrant prostate cancer susceptibility gene., Increase in HOXA1 expression in mammary carcinoma cells at full confluence is E-cadherin-dependent., Results suggest that loss of E-cadherin function is linked to regulation of cell-cell and cell-matrix adhesion, based in part on cell surface expression of alpha2, alpha3 and beta1 integrins., decreased immunoreactivity of E-cadherin in esophageal squamous cell carcinoma was statistically correlated with presence of lymphatic metastases, Our present results show that gastric differentiated-type carcinomas have different characteristics according to the phenotypic marker expression of the tumour in terms of histological findings, E-cadherin expression and pattern of chromosomal changes., Data suggest that tissue expression of E-cadherin could be a useful marker to predict the progression and metastasis of hepatocellular carcinoma., CDH1 promoter methylation, but not mutational inactivation, is part of an entire programme, resulting in epithelial-mesenchymal transition and increased invasiveness in breast cancer, PCP-2 may play an important role in the maintenance of epithelial integrity, and a loss of its regulatory function may be an alternative mechanism for activating beta-catenin signaling., Loss of E-cadherin and Death Associated Protein kinase methylation and expression is more frequent in lymph node metastases of pancreatic adenocarcinoma, Data show that dynamic microtubules regulate the local concentration of E-cadherin at cell-cell contacts., Serum levels may be a prognostic biological marker innonsmall cell lung cancer., Findings demonstrate a stimulatory role for E-cadherin in proliferative regulation, and identify a simple mechanism by which cell-cell contact may trigger or inhibit epithelial cell proliferation in different settings., Reduced E-cadherin expression is related to a poor prognosis through hematogenous metastasis in pulmonary adenocarcinoma., The high frequency of methylation of the CDH1 gene promoter suggests that the inactivation of tumor suppressor genes and of the genes related to the control of cellular proliferation through this mechanism is involved in gallbladder carcinogenesis., E-cadherin pathway is a novel and functionally important mediator by which changes in Kruppel-like KLF6 tumor suppressor can directly alter ovarian tumor invasion and metastasis., Activation of protease-activated receptor-2 (PAR2) interrupted adhesion of E-cadherin-expressing L cells and of primary airway epithelial cells to immobilized E-cadherin extracellular domain. Activation of PAR2 interrupts E-cadherin adhesion., E-cadherin methylation was associated with the inhibition of E-cadherin gene and protein expression in acute myeloid leukemia., These data suggest that endocytosis is the main pathway for the dissociation of E-cadherin adhesive dimers., E-cadherin has a role in head and neck squamous cell carcinoma [review], the degradation of E-cadherin in response to expression of R-cadherin is due to competition for p120(ctn), No significant association between E-cadherin expression and tumor grade, stage, age or gender of the patients, the number of recurrences, or overall survival could be seen., CDH1 mutations are associated with a risk of early-onset gastric cancer., Levels of expression of CtBP and p300 are critical for the action of SNAIL and ZEB1, which have a pivotal role in levels of epithelial-mesenchymsal transitionin human colon carcinoma., E-cadherin immunoreactivity was detected in all the epithelial tissues examined, except adrenal cortical cells and granulosa cells., The mechanism underlying 5-Azacytidine's anti-metastasis activity is associated with restored functional expression of E-cadherin in ovarian cancer., E-cadherin/CDH1 gene methylation is an important cause for its gene silence in diffuse variant gastric carcinoma., Examination of E-cadherin expression and distribution in colorectal tumors can be extremely valuable in predicting disease recurrence., A novel mutation in the E-cadherin gene in a family with hereditary diffuse gastric cancer. The presence of a 1610delC germline mutation was confirmed., CDH1 serum levels may be a serological marker for staging of patients with testicular germ cell neoplasia., Our results indicate a functional role of Met-E-cadherin interaction in MCF-7 cells through the amplification of the signaling downstream of HGF-Met triggering that involved c-Src and phosphoinositide-3-kinase activities., A model is proposed to infer the pathogenic significance of CDH1 germline missense variants., The expression of E-cad was significantly lower in endocrine inactive group than that in endocrine active group of pituitary adenoma., CD24 regulates E-cadherin and TGF-beta3 expression in cultured oral epithelial cells, dysfunction of E-cadherin due to its endocytosis may occur in some proportion of human breast carcinomas in which the PP2A-A protein is lost or significantly reduced, the gain and not the loss of the E-cadherin axis contributes to the invasiveness of inflammatory breast cancer cells unique phenotype, The expression of TGF-beta1 and E-cadherin are correlated with lymph node metastasis in supraglottic larynx squamous cell carcinoma., Roles of E-cadherin and beta-catenin complexes in signet ring cell carcinoma of the lung differ from their roles in gastric or colorectal cancers., loss of extracellular E-cadherin observed in normal duodenal & colonic mucosa in patients familial adenomatous polyposis might play a role in high susceptibility of these tissues for (pre-) malignant transformation, E-cadherin may sensitize human melanoma cells towards apoptosis, E-cadherin expression responds only to the combination treatment and not to single PPARgamma agonists, defining a new class of PPARgamma target genes, SCCA2 regulates cell migration and invasion via E-cadherin expression, suggesting that SCCA2 may be involved in cancer behavior such as invasion or metastasis., Increased N-cadherin expression was found in pseudomyxoma peritonei., SMAD family member 1 is involved in the progression of pancreatic cancer and plays a role in mediating signal transduction from collagen type I to downregulate E-cadherin expression., In conclusion, ROS play a central role in mediating TPA-triggered sustained PKC and ERK signaling for regulation of gene expression of integrins and E-cahedrin that are responsible for EMT and migration of HepG2., VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail, Real-time reverse transcription-PCR and Western blotting were used to assess levels of E-cadherin expression in esophageal cancer., first CDH1 germline mutation of an Italian family with hereditary diffuse gastric cancer is reported, Cell cycle regulation of Six1 occurs both transcriptionally and post-translationally via phosphorylation, E-cadherin repression is necessary for c-Myc-induced cell transformation., alpha2-antiplasmin induction inhibits E-cadherin processing mediated by the plasminogen activator/plasmin system, leading to suppression of progression of oral squamous cell carcinoma via upregulation of cell-cell adhesion, Found in in situ lesions. May play some role in the prognosis/invasion of extramammary Paget's disease., Seven novel mutations within the CDH1 gene are associated with Hereditary diffuse gastric cancer., targeting constitutive expression of AP-2alpha in AP-2-positive KM12C colon cancer cells with small interfering RNA resulted in an increase in their invasive potential, downregulation of E-cadherin and increased expression of MMP-9, These results indicate that perturbation of the E-cadherin/beta-catenin complex by H. pylori CagA plays an important role in the development of intestinal metaplasia., the recruitment of PI3K to the E-cadherin/beta-catenin/p120-catenin complex via beta-catenin at the plasma membrane is required for calcium-induced phospholipase C-gamma1 activation and, ultimately, keratinocyte differentiation, PIPKIgamma links E-cadherin to adaptor protein complexes, E-cad expression to be correlated with E-cad methylation at highly statistically significant levels. Above a threshold of approximately 20% to 30% mean methylation, the expression of E-cad was effectively silenced., High Nonmembranous type E-cadherin expression correlated significantly with lymph node metastasis, distant metastasis, and recurrence regulated by hepatocyte growth factor, Cadherin-E interaction with integrin alphaEbeta7 causes antitumor cytotoxic response by CD8+/CD103+ tumor-reactive T lymphocytes., C. albicans invades mucosal tissues by promoting the proteolytic degradation of E-cadherin in epithelial adherens junctions, mediated by transcription factor Rim101 and Sap5 proteins., Decreased E-cadherin expression is associated with advanced gallbladder cancers, CDHE was expressed in both tumor types, especially in the cytoplasm and cell membrane of the cuboidal cells and to a lesser extent in the polygonal cell membrane, where it was expressed mostly in the cytoplasm., E-cadherin cleavage is enhanced by contact with C. albicans, Data show tha E-cadherin homophilic binding independent of other cell contacts directly transduces growth inhibition by a beta-catenin-dependent mechanism that inhibits selective signaling functions of growth factor receptors., incubation with HGF mediated the release of MMP-7, resulting in extracellular cleavage of E-cadherin from stomach cancer cells, Data show that E-cadherin/beta-catenin-based adherens junctions are dispensable for tight junction formation and apical lumen biogenesis but not for apical lumen remodeling., Decreased E-cadherin is asociated with thyroid cancer, E-cadherin promoter hypermethylation was observed in the tumour of the P373L mutation carrier., None of the 30 infiltrating lobular carcinomas cells showed preserved E-cadherin expression., Together, these findings demonstrate a role for SNX1 in retrieval of E-cadherin from a degradative endosomal pathway and in membrane trafficking pathways that regulate E-cadherin recycling., Differentially regulated beta-catenin pools associate with the E-cadherin-gamma-secretase adherens junction complex; one pool regulated by gamma-secretase is important to intestinal epithelial cell homeostasis., Characterization of endogenous CDHE-CTNNB complexes with ELISA represents a dramatic improvement over other assays., While CDH1 methylation seems to be an early event in Hp gastritis, MLH1 methylation occurs late along with IM., E-cad promoter methylation may play a role in tumor cell differentiation and perineural invasion., Recurrent CDH1 mutations in families with hereditary diffuse gastric cancer are due to both independent mutational events and common ancestry. The presence of a founder mutation from Newfoundland is strongly supported., results of this study show no association exists between the E-cadherin genotype and the risk of tumor recurrence in Chinese patients with hepatocellular carcinoma, Downregulation of E-cadhedrin expression is associataed with increased EGFR downstream signalling and a subsequent increase in expression of Th2-attracting chemokine TARC., The C/A polymorphism of CDHE has a direct effect on the risk of diffuse gastric cancer at young age in Mexican population., E-cadherin signaling is an important activator of c-Src at cell-cell contacts, providing a key input into a signaling pathway where quantitative changes in signal strength may result in qualitative differences in functional outcome., we explored the implication of three proteins (E-cadherin, a- and b-catenins) that form the cadherin-catenin complex, a receptorial structure strictly involved in tumoral vascular invasion and embolization in this biologic event, Aberrant E-cadherin expressions were described in several tumors such as in bladder cancer. This was also found to be correlated with tumor invasion and survival., A tight control of E-cadherin expression depending on the differentiation stage of the progenitor cells, is suggested., In addition to suppressing late-stage tumor progression, E-cadherin-mediated adherens junctions may also contribute to the initial emergence of a cohesive morphogenic phenotype that is a hallmark of differentiated epithelial ovarian carcinoma., NFkappaB activation mediated by loss of E-cadherin may represent an essential, even initial event in colorectal neoplasm metastasis, study demonstrates that E-cadherin represents a ligand for KLRG1 and that ligation of KLRG1 by E-cadherin inhibited effector cell functions of polyclonal NK cells, E-cadherin thus requires both ankyrin-G and beta-2-spectrin for its cellular localization in early embryos as well as cultured epithelial cells., Junctional adhesion molecule-A is critical for the formation of pseudocanaliculi and modulates E-cadherin expression in hepatic cells, The expression of aPKC-iota and E-cadherin may reflect the differentiation and invasive potential of cholangiocarcinoma., Results show E-cadherin-mediated Listeria internalization requires Arp2/3 complex acts as an actin nucleator., The major subtypes of renal epithelial neoplasms display differential aberrant CDH1, PTGS2, and RASSF1A promoter methylation levels. This gene panel might contribute to a more accurate discrimination among common renal tumors., Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells., High level E-cadherin expression and p120ctn localization were associated with esophageal squamous cell carcinoma differentiation and lymph node metastasis, there are significant differences of expression of E-cadherin between primary breast cancer cells and their metastases, Aberrant methylation of multiple genes (E-cadherin, estrogen receptor, RB1 , p16, p15, p14, and MGMT) is involved in gastric carcinogenesis., presence of the A allele of the -160C/A polymorphism in the E-cadherin gene may be a risk factor for prostate cancer in the Japanese population, The expression of E-cadherin was negatively correlated with lymphatic metastasis, clinical stage, and cancer differentiation in gastric cardia carcinoma., a relation between the E-cadherin 3'-UTR C --> T polymorphism, the -160 A/-347 GA haplotype of two promoter polymorphisms and risk of endometriosis, A novel germline CDH1 truncating mutation in the extracellular portion of the protein (517insA) was found in 2 relatives with lobular breast cancer. Germline CDH1 mutations can be associated with invasive LBC in the absence of diffuse gastric cancer., E-cadherin and beta-catenin have roles in progression of Epstein-Barr virus-associated gastric carcinoma, The previously reported characteristics of this mutation, E-cadherin (V832M) do not apply to human epithelial cells expressing this mutant protein., Expression may be reduced in some early gastric carcinomas., Loss of E-cadherin expression is a risk factor for lymph node metastasis in early gastric cancer., The E-cadherin gene methylation presence in tumors with lowest invasive and metastatic potential suggests the early involvement of this epigenetic event in the multistep progression of the oral carcinogenesis, E-cadherin immunostaining was less intense in metaplastic cervical epithelial cells of women on tibolone, whereas hormone therapy and raloxifene were not associated with altered E-cadherin expression., These results demonstrate that lysophosphatidic acid regulates c-Met function through PKC delta and E-cadherin., E-cad expression in gastric carcinoma is relatively low in the internal obstruction of stagnant toxin type and the in-coordination between liver and stomach type., Analysis of interface of In1a protein with E-cadherin to identify single amino acid substitutions in InlA that would potentially improve the overall quality of interaction and hence increase the weak binding affinity of the complex, These data suggest that serine/threonine phosphorylation of p120 influences the dynamics of E-cadherin in junctions., Our findings suggest that the hypermethylation of E-cadherin promoter might be involved in the process of gastric carcinoma through the specialized factors in H. pylori-induced enlarged fold gastritis., convincing evidence that cadherin adhesion is based on high-affinity cadherin-cadherin interactions, MUC1 may affect cancer cell migration by increasing E-cadherin/beta-catenin complex formation and restoring E-cadherin membrane localization, Re-expression of E-cadherin in HT29(US) cells restored the ability of caveolin-1 to down-regulate beta-catenin-Tcf/Lef-dependent transcription and survivin expression, as seen in HT29(ATCC) cells., Our results suggest that methylation of E-cadherin is a frequent, early event in gastric carcinoma progression. Two factors were ...associated with lymph node metastasis, Kallikrein 6 induces E-cadherin shedding and promotes cell proliferation, migration, and invasion., Reduced expression of E-cadherin was associated with short overall survival incolorectal neoplasms, Altogether, our results suggested that E-cadherin mediated cell-cell adhesion was essential for preventing the proteasome degradation of PTEN/, Comparison of the E-cadherin structure with other type I cadherin structures reveals features that are likely to be critical to facilitate dimerization by strand exchange as well as dimer flexibility., ATCTG and CTTTG CDH1 haplotypes may be associated with an increased risk and decreased risk, respectively, of gastric cancer in Japan., tumor-specific downregulation of expression and methylation of CDH13 and CDH1, alone or in combination, may be involved in the development and invasive growth of pituitary adenomas., This paper focuses on changes in E-cadherin (CDH1), adenomatous polyposis coli (APC), and beta-catenin (CTNNB1) in 50 tumors of the central nervous system, there is an aberrant nuclear localization of E-cadherin in CC-RCC harboring VHL mutations, suggesting potential prognostic value of VHL and E-cadherin in CC-RCC., findings suggest E-cadherin-dependent cell-cell contact, directly or indirectly, mediates signal to undergo apoptosis of CaSki cells during multicellular tumor spheroid formation & provides new information on role of E-cadherin in cervix cancer apoptosis, E-cadherin expression is down-regulated in adenoid cystic carcinoma of the salivary glands, which is correlated to nerve invasion, regional recurrence and distant metastasis., Data suggest that Dia1 localizes to and controls E-cadherin-mediated junctions in a RhoA-dependent manner., Somatic E-cadherin mutations affect apoptosis regulation in that way that they can facilitate the disruption of adherens junctions thereby possibly influencing the response to cisplatin-based chemotherapy., Report a potential association of variants in the CCND1 and CDH1 genes with familial colorectal cancer using a unique study design with phenotypic extremes., The current findings suggested that simultaneous methylation of the E-cadherin and H-cadherin genes occurs in a subset of NSCLCs, -160A of the E-cadherin gene is emerging as a low-penetrance tumor susceptibility allele for the development of gastric, lung, prostate, and urothelial cancers., functional significance of combined dysregulation of PKD1 and E-cadherin in prostate cancer; their effect on cell growth is mediated by beta-catenin., removal of N-glycans on E-cadherin resulted in elevated tyrosine phosphorylation level of beta-catenin and reduced beta- and alpha-catenins at adherens junctions, genetic predisposition plays role in hereditary diffuse gastric cancer, analysis of Epstein-Barr virus, beta-catenin, and E-cadherin in gastric carcinomas, CpG island hypermethylation of E-cad gene exists in gastric cancer, which down-regulates E-cad expression and might be involved in tumorigenesis and development of gastric cancer., In colorectal adenocarcinoma, MUC1 expression was negatively correlated to E-cad expression, and MUC2 and MUC5AC expression were positively correlated to E-cad expression., Therefore, a loss of cell-cell junctions, a key process that occurs during the epithelial-mesenchymal transition, should have a broad impact on ER alpha transcriptional functions., KCC3 down-regulates E-cadherin/beta-catenin complex formation by inhibiting transcription of E-cadherin gene and accelerating proteosome-dependent degradation of beta-catenin protein, membranous overexpression of E-cadherin and beta-catenin are associated with the metastatic prostate cancer cells in bone and the high frequency of expression suggests their involvement in the intercellular adhesion of the metastatic cells in bone, Galectin-3 and E-cadherin expressions are associated with lymph node metastasis of colon cancer., The C/C genotype of 3'-UTR C/T SNP and -160C/-374GA haplotype in E-cadherin gene may be a factor for risk of epithelial ovarian cancer in Chinese; the lower expression of E-cadherin might play a role in the pathogenesis of epithelial ovarian cancer., A high frequency of hypermethylation was detected in CDH1 and SFN genes in tumoral and normal cortex tissues., In most hereditary cancer syndromes, like hereditory diffuse gastric cancer and lobular carcinoma of the breast, multiple organ sites are affected by cancer and have been shown to be associated with germline mutations in CDH1 at 16q22.1., Silencing Cdc42 blocks activation of EGFR and Src induced by Ca2+ depletion, resulting in a reduction in E-cadherin degradation, The expression of E-cadherin was significantly lower in supraglottic carcinoma than that in normal laryngeal mucosa., Using transient promoter assays, we show that Twist can down-regulate E-cadherin promoter activity by up to two folds., the CaR regulates cell survival and Ca(2+)(o)-induced differentiation in keratinocytes at least in part by activating the E-cadherin/PI3K pathway through a Src family tyrosine kinase-mediated signaling, in addition to the previously implicated tumor suppressor activity of E-cadherin, modified forms of this glycoprotein might also play a role in growth promotion, Micrometastasis was significantly correlated with the depth of invasion, tumor size, operation method, Lauren classification, lymphovascular invasion and loss of E-cadherin expression in primary tumor., that the heterogeneous pattern of SCCA and E-cadherin in primary lesions is strongly associated with the high incidence of lymph node metastasis in cervical squamous cell carcinoma, changes of Ecadherin (CDH1) and beta-catenin (CTNNB1) genes in two central nervous system germ cell tumors are reported; both germ cell tumors analyzed demonstrated LOH of the CDH1 gene, the APC has a novel role in UV-induced cell death; APC/CDH1 is regulated through proteolysis, E-cadherin expression is frequently reduced in laryngeal squamous epithelium of patients with laryngopharyneal reflux., Rac signaling to cyclin D1 is a crucial pro-proliferative effect of E-cadherin-mediated cell-cell adhesion, in solid pseudopapillary neoplasm of the pancreas E-cadherin expression moved from membranous to intracytoplasmic localization, The CDH1 C-160A polymorphism is not associated with the risk of CRC in the German population, The present study indicates that CDH1 single nucleotide polymorphisms might modify susceptibility to esophageal squamous cell carcinomas and gastric cardia adenocarcinomas, ADAM10-mediated E-cadherin proteolysis leads to the impaired cohesion of keratinocytes observed in eczematous dermatitis., Noncohesive pancreatic cancers were characterized by the loss of E-cadherin protein expression. Promoter hypermethylation is a possible mechanism of E-cadherin gene silencing in a subset of these cancers., The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression., The expressions of aPKC-iota and E-cadherin may reflect the differentiation and invasive potential of cholangiocarcinoma, E-cadherin mutant missing N-glycans at Asn554, Asn566 and Asn618 failed to induce cell cycle arrest in G1 phase and to suppress cell proliferation in comparison with wild-type E-cadherin., Increased histone acetylation might be responsible for PGC-1alpha-mediated transactivation of a minimal E-cadherin promoter., study describes activation of EGFR by mutant E-cadherin as a novel mechanism in tumor cells that explains the enhanced motility of tumor cells in the presence of an extracellular mutation of E-cadherin, Expression of S100A4 protein and loss of E-cadherin protein expression are significantly associated with tumor progression in non-small cell lung cancer., The abnormal expression of CDX(2) and E-cadherin plays an important role in the development of gastric carcinoma., Vpu leads to the depression of both total and beta-catenin-associated E-cadherin levels through beta-TrCP-dependent stabilization of the transcriptional repressor Snail., PTPRK influences transactivating activity of beta-catenin in non-tumoral and neoplastic cells by regulating the balance between signaling and adhesive beta-catenin, thus providing biochemical basis for the hypothesis of PTPRK as a tumor suppressor gene., E-cad, CD44v6 and PCNA play important roles in invasion and metastasis of non-small cell lung cancer (NSCLC)., Decreased E-cadherin may be important in the development of endometrial endometrioid carcinoma., Combined analysis of Cripto-1 and E-cadherin has significant value in evaluating the metastatic potential of gastric cancer and predicting patient prognosis., levels in colon carcinomas were not statistically different from levels in adjacent normal mucosa and were not correlated with tumor, nodes, and metastases stage, The disassembly of E-cadherin complexes from junctions in human keratinocytes was induced by Rac1 and Rac3 via activation of the Rac target PAK1., These results lead to a new hypothesis that Snail and ZEB1 are downstream of CCN6 and play a critical role in CCN6-mediated regulation of E-cadherin in breast cancer., p35 co-expression targets E-cadherin to lysosomes and p35-triggered disappearance of E-cadherin precursor can be blocked specifically by lysosomal protease inhibitors, indicating p35 induces endocytosis and subsequent degradation of precursor E-cadherin, results indicate that Src and E-cadherin may play an important role in epithelial-mesenchymal transformations, invasion, and aggressive clinicopathologic features of head and neck squamous carcinoma, E-cadherin expressioni in adenomas suggest that this molecule might have role in adenoma formation though not necessarily be involved in neoplastic progression., LIV-1 may be a regulator of E-cadherin, ASH1 inactivates DKK1 and DKK3, negative regulators of Wnt/beta-catenin signaling, E-cadherin, and integrin beta1 through ASH1-mediated deacetylation and repressive trimethylation of lysine 27 of histone H3 in the promoter regions of DKK1 and E-cadherin., No CDH1 polymorphisms or haplotypes were associated with GC risk, no differences of effect were seen by H pylori infection. Three CDH1 polymorphisms in the same haplotype interacted with smoking to increase GC risk in smokers but not in never smokers., The heterotypic trans-interaction of LI- and E-cadherin might play a role during development of the intestinal epithelium when the cells do not yet have elaborate membrane specializations., Methylation of CDH1 was present in 80% of NSCLC tissues but only in 14% of noncancerous tissues., Activin A downregulates E-cadherin expression in endometrial cells., This study provides into the mechanisms underlying the functional role of EZH2 overexpression in gastric cancer cells and a new modality of regulation of E-cadherin expression in silencing mechanisms of tumor suppressor genes., Positive staining for E-cadherin should not preclude a diagnosis of lobular in favor of ductal carcinoma., Cdh1 may act as an important component in tumor suppression and could be considered as a novel biomarker in breast cancer., The -160A, 234 2I allele and haplotype A-A-T-2I were risk factors of Transitional Cell Carcinoma of the Bladder. Haplotype C-A-T-I might act as a protective factor for TCCB., transforming growth factor-beta1 indirectly reduces antigen-presenting cell density in EpM by affecting E-cadherin expression, which might explain the increased susceptibility of abnormal tissue differentiation., superficial intramucosal signet ring carcinoma, although widespread, is predominantly located in the proximal one third of the stomach in patients with E-cadherin gene mutations., Data show that the haplotype the E-cadherin gene may have impact on the risk of epithelial ovarian carcinoma. The CC genotype of 3'-UTR + 54CT may be a potential risk factor for the epithelial ovarian carcinoma., study of correlation between mutations & expression of E-cadherin, beta-catenin, occludin & claudin & complexity of colon carcinoma growth; perturbed expression & distribution of these proteins was found, but could not be linked to complexity of growth, loss of expression of the miR-200 family members may play a critical role in the repression of E-cadherin by ZEB1 and ZEB2 during EMT, thereby enhancing migration and invasion during cancer progression., Rsults suggest that the lower epithelial alpha-catenin, E-cadherin and (or) ZO-1 expression in patients with atopic asthma contributes to a defective airway epithelial barrier and a higher influx of eosinophils in the epithelium., The nonsense-mediated-decay mRNA surveillance pathway downregulates aberrant E-cadherin transcripts in gastric cancer cells and in CDH1 mutation carriers., ADAM15 catalyzes the cleavage of E-cadherin to generate a soluble fragment that in turn binds to and stimulates ErbB receptor signaling, Data show that loss of E-cadherin expression was independent prognostic factor for progression-free survival., aberrant or decreased expression of E-cadherin seems to be one of most promising markers of poor prognosis in localized prostate cancer, promoter-hypermethylation of E-cad is significantly associated with its defective expression and tumor differentiation in non-small cell lung cancer, Reduced expression of E-cadherin may have a role to play in the pathogenesis of invasive Paget's disease of the vulva., The CDH1 163+37235G>A polymorphism may represent a novel susceptibility variant for sporadic diffuse gastric cancer, E-cadherin loss in tumors contributes to metastatic dissemination by inducing wide-ranging transcriptional and functional changes, N-glycosylation at Asn-633 is essential for E-cadherin expression, folding and trafficking., results indicate that E-cadherin in the nevus cells of the giant congenital nevocellular nevi may affect nevus cell motility rather than intercellular attachment, data did not support a crucial role of promoter methylation of the E-cadherin gene in the remarkable downregulation of E-cadherin expression in colorectal cancers, E-cadherine and CD44 immunoexpression in oral squamous cell carcinoma as prognosis factors., Loss of E-cadherin-mediated adhesion led to acquisition of phenotypic properties that augmented cell motility and directed transition from precancer to cancer in skin-like tissues., loss of E-cadherin is probably consequent on p120 loss or decrease. Aberrations and other alterations of the E-cadherin gene are unlikely to be responsible for the loss of E-cadherin in solid pseudopapillary tumors., Results suggest that a decrease in E-cadherin gene expression level in high-grade neuroepithelial tumors may be a hallmark of malignancy in dedifferentiated tumors and that it may be possibly correlated with their progression and dissemination., Core-fucosylated E-cadherin regulated nuclear beta-catenin accumulation in lung cancer cells., Loss of e-cadherin is associated with ovarian carcinoma, E-cadherin may have a role in inhibition melanoma invasiveness by epigallocatechin-3-gallate, Time-lapse microscopy in live cells showed that the recycling endosome is always requisite for E-cadherin sorting and trafficking., Results suggest that histone H3 deacetylation plays a crucial role in transcriptional repression of E-cadherin in colorectal cancers., rather than being translocated to the nucleus for regulating the target gene transcription, Smad7-stabilized-beta-catenin is shunted to the E-cadherin complex to modulate cell-cell adhesion., Rb depletion results in deregulation of E-cadherin., The Matrix Metalloproteinase (MMP-2, MMP-9) to E-cadherin (M/E ratio) characterizes an important aspect of the molecular phenotype associated with the histologic progression of prostate cancer among African American prostate cancer patients., Results show that InlA triggers two successive E-cadherin post-translational modifications, the Src-mediated tyrosine phosphorylation of E-cadherin followed by its ubiquitination by the ubiquitin-ligase Hakai., Hypermethylation of E-cadherin was found in 28 of 38 nasopharyngeal carcinoma, Sequence analysis of the high-frequency region along E-cadherin exons 7-9 revealed a number of sequence alterations in the patient group as a whole. A C insertion at nt 76,598 was found in 2 African American patients., Decreased immunoexpression of beta-catenin and E-cadherin in serous ovarian tumors may be helpful in identifying the cases of higher metastatic potential and infiltration ability., Results show a correlation of CDH1 and APC promoter methylation with loss of E-cadherin and APC proteins and with activation of Wnt/beta-catenin signaling pathway., beta-catenin expression was significantly related to E-cadherin and MMP-7 expression, Increased dysadherin expression is possibly one of the post-transcriptional mechanisms responsible for E-cadherin downregulation in thyroid papillary neoplasia., Only borderline results for the association of AXIN2 and CDH1 with oral clefts with and without tooth agenesis., loss of expression is related to bone metastasis in prostate cancer, The significant difference in methylation of CDHE observed in liver neoplasms and liver cirrhosis was not observed in plasma samples., hypermethylation of CDH1 and integrin alpha4 genes may be used as recurrence-associated prognostic indicators in stage I and stage II esophageal squamous cell carcinoma, respectively., important role of the E-cadherin/beta-catenin/Tcf signaling pathway in atherosclerosis., In the gastric cancerous tissues, the expression percentage of Wnt-1, beta-catenin and E-cadherin is 54.4%, 45.6%, 47.2%, respectively, which is significantly higher than the percentage expression of these genes in normal tissues (p<0.01)., By inhibiting E-cadherin expression and enhancing ICAM-1 expression, LMP1 may reduce the cell-cell adhesive ability and improve the cell-matrix adhesive ability and migratory ability of nasopharyngeal carcinoma cells., Patients who had tumors with CDH1 hypermethylation had significantly better overall survival compared with patients who had tumors without hypermethylation (P < .02; log-rank test), significant association of concurrent expression of unmethylated E-cadherin gene and E-cadherin protein with metastatic prostate cancer cells in bone. May have role in intercellular adhesion in formation of metastatic lesions in bone., The abnormal expression of E-cadherin and beta-catenin were closely related with differentiation, clinical stage, metastasis in laryngeal carcinoma., cadherin-mediated cell-cell contact regulates early keratinocyte differentiation independently from changes in cell shape, Cdh1-dependent degradation of FoxM1 is required to shut down transcriptional activation of mitotic regulators during exit from mitosis., The -347del allele of E-cadherin strongly links with the +178T and +234 13N ins alleles. The -347del/del genotype may increase susceptibility of sporadic gastric carcinoma among males in high-risk areas of China., study demonstrated that E-cadherin missense mutants are subjected to Endoplasmic Reticulum Quality Control (ERQC) and that their loss is due to endoplasmic reticulum-associated degradation, ILK silencing inhibited binding of PARP-1 to SIRE, Overall meta-analysis indicated that the -160A allele carriers (CA+AA) had a 21% elevated risk of prostate cancer, when compared with the homozygotes (CC) (OR=1.21; 95% CI, the activated AR can downregulate E-cadherin expression to promote the activation of epithelial-mesenchymal transition and tumor metastasis., Discontinuous staining of N-cadherin and loss of E-cadherin expression in hepatocellular carcinoma predicts a high risk of recurrence after surgical treatment., In human HCC tissues, we observed a correlation among ROS induction, E-cadherin down-regulation, Snail up-regulation, and E-cadherin promoter methylation., The presence of E-cadherin in tumors correlated with the absence of metastases in regional lymph nodes and was observed, as a rule, in the patients at the early stages of the disease., Activated Akt seems to characterize well-differentiated invasive squamous laryngeal carcinomas, loss of E-cadherin and activation of beta-catenin correlated with high grade carcinomas., The results presented here describe the expression of E-cadherin in the male reproductive tract and gametes and strongly suggest its involvement in adhesion events during human fertilization., Tbx2 and Tbx3 may play a dual role during the radial to vertical growth phase transition by both inhibiting senescence via repression of p21(CIP1) expression, and enhancing melanoma invasiveness by decreasing E-cadherin levels., Reduced expression of E-cadherin/catenin complex in hepatocellular carcinomas., In hepatocellular carcinoma (HCC), there is a negative correlation between the positive expression of p130Cas and the normal expression of E-cadherin/beta-catenin. p130Cas plays important roles in the invasion, metastasis and prognosis of HCC., Tissue and urine expression of E-cadherin in bladder transitional cell carcinoma are very closely associated with the biological behavior of the neoplasm., E-cadherin confer significantly different characteristics on cells., E-cadherin plays an important role in uterine receptivity., Reduced Cdh1 levels have no effect on destruction of many APC/C substrates during mitotic exit but strongly and specifically stabilize Aurora kinases., We suggest that CDH1 cytoplasmic immunolocalization as a result of increased IGF-II levels identifies those nonmuscle invasive presentations most likely to recur, The resistance of E-cadherin over-expressing cells to staurosporine may due to the up-regulation of Bcl-2/Bax ratio. When E-cadherin interference plasmids were transfected into MCF-7 cells, Bcl-2 expression was down-regulated., E-cadherin was strongly expressed in urothelial cell carcinoma in situ (CIS) of the bladder., Ras transformation has at least two independent actions to disrupt E-cadherin junctions, with effects to cause both mislocalization of E-cadherin away from the cell surface and profound decrease in the expression of E-cadherin, the over-expression of EphA2 or the down-expression of E-cadherin is correlated with cancer progression and lymphogenous metastasis in gastric cancer., Expression of p53, BCL-2 and Ki-67 was upregulated in clinically localized prostate cancer compared with benign prostate tissue, with no alteration in E-cadherin expression., recruitment of E-cadherin expression by Connexin 43 and inhibits the malignant behaviour of lung cancer cells, N/E- cadherin expression profile has a significant prognostic value in invasive bladder cancer., The C-160A polymorphism is not associated with gastric cancer risk in the Italian population., overexpression of SRF in colorectal carcinoma cells is associated with modulation of E-cadherin/beta-catenin expression and may play an important role in colorectal cancer metastasis., alterations in beta-catenin/E-cadherin complex play a critical role in spindle and/or corded (SPICO) cells' features, In polarized epithelial cells, E-cadherin regulates AMPK phosphorylation by controlling the localization of the LKB1 complex., The reduced immunoexpression of E-cadhedrin in the membrane may be related to the high degree of cell indifferentiation in cases of oral squamous cell carcinoma with high scores., metastasis and survival of patients with bladder cancer are mediated, at least in part, by E-cadherin, augmented production of HA and the decreased E-cadherin expression by keratinocytes stimulated with IL-4/IL-13 or IFN-gamma cause spongiosis in acute eczema, There was increased expression of E-cadherin and beta-catenin in the eutopic and ectopic endometrium in adenomyosis., of promoter hypermethylation of TIMP3, CDH1, DAPK, RASSF1A, p16INK4A and MGMT, only the epigenetic silencing of TIMP3 and CDH1 predicted a better outcome in head and neck squamous cell carcinoma, E-cadherin-mediated adherens junctions formation contributes to PI3K/AKT activation in epithelial ovarian cancer (EOC) by a mechanism that provides basis for therapeutic strategies that exploit PI3K inhibition to halt EOCs, E-cadherin truncation and sLeX overexpression are early events which may facilitate the tumor cells in oral cancer to metastasize, E-cadherin, beta-catenin, and ZEB1 have roles in malignant progression of cancer [review], the overexpression of epithelial cell adhesion molecule and reduced expression of E-cadherin in combination is more significant than a single marker for predicting poor survival., Cleavage of the extracellular domain and nuclear translocation of E-cadherin is a common event that may determine local invasion in pituitary adenomas., Abnormal p120-catenin expression correlates with abnormal E-cadherin expression and specific small GTPase overexpression, which contribute to the malignancy-related to NSCLC., Germline deletions of CDH1 are one of the mechanisms underlying hereditary diffuse gastric cancer., Cell surface E-cadherin expression level was significantly lower in leukemia cells than in normal hematopoietic progenitors., Polyamines regulate E-cadherin transcription through c-Myc modulating intestinal epithelial barrier function., Urinary soluble 80kDa fragment of E-cadherin has a potential clinical diagnostic value for diabetic nephropathy and E-cadherin may participate in the pathogenesis of DN., Hypermethylation of E-cadherin, p14 or RASSF1A in urine sediment DNA is a potential biomarker for detecting superficial, low grade cancer, ZO-1, occludin, and E-cadherin are downregulated in carcinomas arising from various compartments of the biliary tract, Cell separation or abrogation of E-cadherin-mediated cell-cell contacts both cause a dramatic increase in accumulation of the c-Jun protein., uterine non-endometrioid (papillary serous and clear cell) carcinomas were less likely to express E-cadherin compared with endometrioid carcinomas and normal endometrial tissue, E-cadherin deficiency initiates gastric signet-ring cell carcinoma in mice and man., Data show that Wnt-5a stimulation of breast epithelial cells leads to increased cell-cell adhesion, and that Wnt-5a/casein kinase Ialpha (CKIalpha)-specific phosphorylation of beta-catenin leads to increased complex formation of beta-catenin/E-cadherin., Results suggest that Ecad mutant forms lack some specific interaction shown by the wild type hEcad, and that these missing (or altered) interactions would play a role in tumour formation., the different 2nd hits in CDH1 occurring in neoplastic lesions from hereditary diffuse gastric cancer patients was quantified, data suggest that Dkk-1 stimulates the release of beta-catenin from cell membrane and facilitates cell migration which accompanies degradation of beta-catenin/E-cadherin, Collagen type I may influence the expression of E-cadherin and beta-catenin in carcinoma ex-pleomorphic adenoma., E-cadherin expression was reduced in hepatocellular carcinoma., p190RhoGAP and p120ctn associated predominantly on the plasma membrane of cells overexpressing E-cadherin, and that E-cadherin-bound p120ctn contributed to RhoA inactivation by favoring p190RhoGAP-RhoA association., core fucosylation regulates the processing of oligosaccharides and turnover of E-cadherin, NGAL overexpression altered subcellular localization of E-cadherin and catenins and decreased E-cadherin-mediated cell-cell adhesion., up-regulation of E-cadherin is an early defining event in ovarian cancer and may play a significant role in the initial development of the primary ovarian tumor, N- and E-cadherin expression in the human fetal ovary indicates likely roles in gonadal development from germ cell proliferation to primordial follicle formation, as well as in the development of the urogenital ducts of both genders., Loss plays an important role in progression of oral squamous cell carcinoma, that is, down regulation of its expression is associated with de-differentiation and metastasis, Low Cdh1 expression is associated with breast cancer., E-cadherins engaged at junctions do not directly revert to free membrane diffusion, This review highlights recent advances in defining the mechanisms that regulate E-cadherin expression in breast cancer., these results suggest a novel role for the ERalpha that plays the dual role of ligand-independent activator and ligand-dependent repressor of E-cadherin in breast cancer cells., changes in the Akt/beta-catenin pathway play key roles in the regulation of E-cadherin through the transactivation of the Slug gene in uterine carcinosarcomas., aberrant expression of E-cadherin may contribute to cell motility and invasion in breast tumors, Downregulation of E-cadherin and diffuse membranous beta-catenin expression suggest a dysregulation of the E-cadherin/beta-catenin complex in Merkel cell carcinoma., results demonstrate an association between polymorphisms within the CDH1 (E-cadherin) gene and Crohn's disease, which leads to cytoplasmic accumulation of E-cadherin instead of its normal localisation at the plasma membrane/adherens junction., MGAT3 and MGAT5 competitively modified E-cadherin N-glycans., alpha(2)-, alpha(3)-, and beta(1)-integrins and E-cadherin expression in normal human lung and bronchopulmonary sequestration and congenital cystic adenomatoid malformation were evaluated using Western blot and immunohistochemistry., E-cadherin regulates both the PTEN protein levels and its recruitment to cell-cell junctions, which integrates proliferative and morphogenetic signaling in breast epithelial cells., reduced syndecan-1/E-cadherin expression may be good indicators of recurrence and prognosis in extrahepatic bile duct carcinoma., Novel role for shear in regulating the endocytosis of E-cadherin and invasiveness in metastatic esophageal cancer cells., PRL-3 promoted downregulation of E-cadherin., decreased expression of E-cadherin in upper urothelial carcinoma (UUC) in regions affected by Balkan Endemic Nephropathy tumors may be linked to tumor growth, while expression of E-cadherin in control tumors may be associated with tumor grade., SFK and cortactin constitute an important signaling pathway that functionally links E-cadherin adhesion and the actin cytoskeleton, the tensile strength and the lifetime of single E-cadherin/E-cadherin bonds between parental cells are significantly lower over a wide range of loading rates, hepatocellular carcinoma with cirrhosis was characterized by a significantly low expression of E-cadherin, This report underlines that prophylactic gastrectomy remains the only option to eliminate the high risk for gastric cancer in CDH1 mutation carriers., Cdh1 reciprocally regulates the Rb pathway through competing with E2F1 to bind the hypophosphorylated form of Rb., These results suggest that alpha(5)-integrin up-regulation induced by E-cadherin loss under hypoxia has a crucial role in regulating the migration of extravillous trophoblast cells., e-cadherin is diminished in superficial koilocytotic cells' foci in Epidermodysplasia verruciformis, Data show that overexpression of shrew-1 leads to preformation of an E-cadherin/EGF receptor/HER2/src-kinase/shrew-1 signaling complex and accelerated E-cadherin internalization., Results indicate that the expression of E-cadherin transcriptional repressors increased with malignancy in ovarian epithelial neoplasms., Studies show for the first time that DPAGT1 is an upstream regulator of E-cadherin N-glycosylation status and adherens junction composition and suggest that dysregulation of DPAGT1 causes disturbances in intercellular adhesion in oral cancer., MMP1 and MMP3, but not CDH1, IGFBP3, STK15 or VEGF, appear to play roles in familial and sporadic renal cell carcinoma, The C/C genotype of CDH1 might be a potential risk for cervical cancer development, Data indicate CDH1-160C>A is a risk factor for CRC, and because a high proportion of the European population are carriers of at-risk genotypes, the variant is likely to contribute substantially to the development of colorectal cancer (CRC)., E-cadherin, a tumor invasion suppressor in HCC, was found to be a putative gene target of miR-9. E-cadherin was up-regulated by miR-9 inhibitor., Mtation of E-cadherin influences Rac1 and Rho activation in opposite directions., Immunohistochemical analysis of E-cadherin and Zeb-1 in primary tumors confirmed that expression of the two proteins was mutually exclusive., cross-talk between ERalpha and EGFR could be extended to the modulation of E-cadherin expression by 4-hydroxytamoxifen and epidermal growth factor, hMSCs caused breast cancer spheroids to become disorganized which was accompanied by a disruption of cell-cell adhesion, E-cadherin cleavage, and nuclear translocation of E-cadherin, Using in vitro infection assays, the authors showed that Helicobacter pylori CagA interacts with E-cadherin, p120-catenin, and c-Met., E-cadherin may coengage KLRG1 and alpha(E)beta(7) and that KLRG1 overcomes its exceptionally weak affinity for cadherins through multipoint attachment to target cells, resulting in inhibitory signaling., MELF-type invasion represents a specific tumour alteration, and the reduction in hormone receptor and E-cadherin expression would be consistent with epithelial-mesenchymal transition., Interstitial trophoblastic cell fusion and E-cadherin immunostaining in the placental bed of normal and hypertensive pregnancies., Data suggest that E-cadherin-based cell-cell adhesion limits Wnt signals by promoting the activity of a junction-localized beta-catenin phosphodestruction complex, which may be relevant to tissue morphogenesis and cell fate decisions during development., Short-term preoperative treatment of celecoxib up-regulates the expression of E-cadherin in gastric carcinomas., E-cadherin and metalloproteinase-1 and -7 polymorphisms have roles in colorectal cancer, Data show that caveolin-1 and E-cadherin closely associated at cell borders and in internalized structures upon stimulation, Data suggest that cadherin dimerization proceeds via an induced fit mechanism where the monomers first form a tryptophan-2 independent initial encounter complex and then undergo subsequent conformational changes to form the final strand-swapped dimer., Down reglation of E-cadherin is associated with rhabdomyosarcoma., increased E-cadherin and alpha-catenin expression and reduced Wnt signaling might be involved in the mechanisms of tumor suppressor function of BCSC-1., Expression of E-cadherin was negative in all leiomyosarcomas., Infection with H. pylori provokes shedding of the ectodomains of c-Met and E-cadherin. ADAM10 contributes to the shedding of c-Met and E-cadherin., Investigated methylation status of the CDH1 promoter in gastric cancer patients. A difference was found between the methylation level of the two alleles in some samples, but there was no mono-allelic promoter hypermethylation in any of the samples., The main objectives were to assess tumor proliferation and invasiveness biomarkers (Ki-67, E-cadherin) and to identify potential correlation between biomarkers and classic prognostic factors in cervical cancer., E-cadherin and p63 are implicated in tumoral progression and may be used as a prognostic markers., miR-200a appears to act as a multifunctional tumor suppressor miRNA in meningiomas through effects on the E-cadherin and Wnt/beta-catenin signaling pathways., the ability of CBX7 to positively regulate E-cadherin expression by interacting with HDAC2 and inhibiting its activity on the E-cadherin promoter would account for the correlation between the loss of CBX7 expression and a highly malignant phenotype, pH 6.6 activates Src kinases, resulting in tyrosine phosphorylation of E-cadherin and p120ctn and a weakening of the association of E-cadherin with p120ctn and contributing to the instability of E-cadherin at adherens junctions, This study identifies the E-cadherin/catenin complex as a discriminative, partly polyamine-regulated feature of IL-4/IL-13-exposed alternatively activated macrophages, Simultaneous analyses of fascin-1 and E-cadherin expression could be more effective in evaluating the prognoses of patients with laryngeal squamous cell carcinoma., novel mechanism of E-cadherin gene inactivation, with CLL cells displaying a higher proportion of aberrant nonfunctional transcripts and resulting up-regulation of the wnt-beta-catenin pathway, High methylation status of the 5' CpG island of E-cadherin gene may be one of the mechanisms in the development of gastric cardiac adenocarcinoma., aids in Wnt/beta-catenin signal transduction in invasive ductal carcinoma of breast, In squamous cell lung cancer or lung adenocarcinomas, the abnormal cytoplasmic expression of p120ctn isoform 1 always correlates to the abnormal expression of E-cadherin., The expression of RKIP and E-cadherin in prostate cancer tissues was obviously lower than that in the benign prostatic hypertrophy tissues., CDH1 gene germ-line mutations are relatively rare in hereditary gastric cancer in China, whereas CDH1 somatic mutations and promoter methylation synergistically induce CDH1 downregulation in these patients., Data show that elevated Snail expression by Pdcd4 knockdown leads to downregulation of E-cadherin resulting in activating beta-catenin/Tcf-dependent transcription., The present findings point to a significant association between reduced E-cadherin expression and the progression and aggressivity of breast lesions., a decrease in CDH1, CDH13, and TIMP3 expression levels with an increase in CD44 can be used as an indicator for invasion in both ER-positive and -negative breast tumors., Data show that conversion of Ras-expressing keratinocytes from a premalignant to malignant state induced by decreasing E-cadherin function was associated with and required an approximately two to threefold decrease in RalA expression., Histologically normal tissue adjacent to tumor tissue expressing the epithelial-mesenchymal transition-inducing gene SNAI1 shows alterations in the expression of epithelial differentiation genes such as CDH1 and VDR., these findings suggest that Cdh1 controls TACC3 protein stability during mitotic exit., genetic variation in E-cadherin may be associated with breast cancer risk, and that this relationship may vary by menopausal status., Up-regulation of E-cadherin by microRNA through direct targeting of transcriptional repressors of E-cadherin, inhibits tumor progression in breast cancer cells., no evidence for the presence of aberrant methylation sites of E-cadherin in tumors from patients with NSCLC, The abnormal expression of E-cadherin and P(120ctn) is closely related to the degree of differentiation, clinical stage and cervical lymph node metastasis in nasopharyngeal carcinoma., Data show that P-cadherin overexpression in breast cancer cells with wild-type E-cadherin promotes cell invasion, motility, and induces the secretion of MMP-1 and MMP-2, which then lead to P-cadherin ectodomain cleavage., Our results suggest that genetic instabilities of the E-cadherin gene have a role in meningioma development and progression, The -347G-->GA promoter polymorphism in E-cadherin gene is associated with specific CRC features, and may be a prognostic factor rather than a susceptibility factor during the progression of CRC., The combination of the upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complexes at the tumour invasive front may provide a useful prognostic marker in oral squamous cell carcinoma., CDH1 new susceptibility loci for ulcerative colitis, the extracellular domains of E- and N-cadherin determines the basic localization pattern, whereas the cytoplasmic domains modulate it thereby affects the cell adhesion activity, subapical accumulation, and the formation of adherens junction., Abnormality of E-cadherin expression was related to lymph node metastasis and advanced clinical stage of Her2-positive breast cancer., Immunohistochemistry on TMAs of 178 gastric cancers showed no correlation between COX-2 and E-cadherin expression in the conventional or early gastric cancer, Results show that disruption of E-cadherin junctions and enhancement of cell invasion by beta-estradiol stimulation was mediated by NO-dependent activation of c-Src., In gastric carcinoma, up-regulation of CD147 and down-regulation of E-cadherin are in a negative correlation., IBH-6 and IBH-4 breast cancer cells show down-regulation of E-cadherin expression with aberrant protein localization, and up-regulation of Twist; these features can be related to their invasive/metastatic characteristics., CpG hypermethylation is an important mechanism of E-cad gene inactivation in ES-2 and SKOV3 ovarian carcinoma cell lines., Allele-specific CDH1 downregulation and hereditary diffuse gastric cancer, Cadherin can be used to discriminate between high- and low-risk papillomavirus in urethral cytologic specimens., Either overexpression of a key regulator of cell cycle, Mad2, or knock down of Aurora B, an important kinase in mitosis, or Cdh1, a key E3 ligase in cell cycle, resulted in a significant increase of SP cells in CNE-2., Malignant drug resistant breast tumors are characterized by reverse relation between E-cadherin expression level and their proliferative activity, Evaluation of Twist and E-cadherin expressions should be useful for determining tumor properties, including prognosis, in patients with esophageal squamous cell carcinoma, molecular pathway from hypoxia to cellular transformation includes up-regulation of HIF and subsequent transcriptional induction of LOX and LOXL2, which repress E-cadherin and induce epithelial to mesenchymal transition, The results indicate that developmentof an invasive carcinoma from an intraductal papillary mucinous neoplasms of pancreas (IPMN) is associated with a decrease in tumor cells expressing E-cadherin and beta-catenin and higher proliferative activity., E-cadherin methylation plays an important role in the carcinogenesis of colon carcinoma cells, and can re-express after treatment with 5-Aza-CdR., The TLR9, IL6, and CDH1 variants all persisted as independent risk factors for post-infectious irritable bowel syndrome (PI-IBS) when controlling for previously identified clinical risk factors., Differentiated prostate cell survival depended on E-cadherin and PI3K, but not keratinocyte growth factor, androgen, AR or MAPK., siRNA for HDAC3 reduced the cell migration with elevated E-cadherin expression, E-cad was profiled in the NCI-60 cancer cell lines at the DNA, RNA, and protein levels using six different microarray platforms plus bisulfite sequencing., Listeria monocytogenes internalin interacts with E-cadherin [review], Glycolysis-promoting enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, isoform 3 (PFKFB3), is degraded by the E3 ubiquitin ligase APC/C-Cdh1., Gene methylation (CHFR, E-cadherin, BNIP3) in the peritoneal fluid could detect occult neoplastic cells in the peritoneum and might be a risk factor for peritoneal metastasis., an interaction between beta-catenin and vinculin is crucial for stabilizing E-cadherin at the cell surface, Results indicate that cells underwent EMT exhibited overactive TGFbeta signaling and loss of expression of the CDH1, CGN, CLDN4, and KLK10 genes as a result of hypermethylation of their corresponding promoter regions., E-cadherin showed a reciprocal staining pattern to ILK in 21 of 25 cases, with only focal expression of the marker in pancreatic adenocarcinoma., one seminoma and three nonseminomas showed LOH of CDH1, Data show there was a strong inverse correlation between slug and ERalpha and E-cadherin immunoreactivity in breast cancer cases., Hypermethylation of E-Cadherin is associated with cervical carcinoma., E-cadherin and beta-catenin are differently expressed and distributed in prostate cancer cell lines with different characteristics of epithelial-mesenchymal transition., the AA (rather than CC) genotype of E-cadherin is associated with increased susceptibility and advanced pancreatic carcinoma in Chinese patients., integration of Rac1 and Rab7 activities by Armus provides an important regulatory node for E-cadherin turnover and stability of cell-cell contacts, cadherin switching and p120(ctn) signaling as important targets of GnRH function and as novel mediators of invasiveness and tumor progression in ovarian cancer., High nonmembranous E-Cadherin expression was associated with advanced clinical stage, lymph node metastasis in nasopharyngeal carcinoma., L1 binding to ankyrin alters the regulation of neuronal branching and leads to a decrease in perisomatic synapses of GABAergic inhibitory interneurons in the developing transgenic mouse cingulate cortex., miR-9 miRNA downregulates E-cadherin. Expression of miR-9 is activated by MYC and MYCN, which bind to the mir-9-3 locus. Elevated expression of miR-9 may contribute to epithelial-mesenchymal transition and metastasis in some and possibly many tumours., The activation of Ezrin and the absence of E-cadherin contribute to the tumorigenesis and metastasis of esophageal squamous cell carcinoma., decrease of E-cadherin and the gain of N-cadherin gene expression are risk factors for cancer-related death in bladder cancer, E-cadherin expression predicts precancerous lesions of the larynx., The results showed no differences in the expression of E-cadherin between tooth germs and solid and unicystic ameloblastomas., These findings indicate that independent control of E-cadherin expression and cell motility could be essential molecular events in p53 mutant-induced invasive phenotypes., Reduced E-cadherin expression may correlate to a dedifferentiated phenotype in the somatotroph pituitary adenomas., Kruppel-like factor 4 inhibits epithelial-to-mesenchymal transition through regulation of E-cadherin gene expression, increased expression of Cx43 and E-cadherin may contribute to the efficient metastasis of gastric cancer to the lymph nodes., increased binding of DNMT3b to E-cadherin promoter region by K-Ras cause promoter hypermethylation for reduced expression of E-cadherin, leading to the decreased cell aggregation and increased metastasis of human prostate cancer cells., Loss of E-cadherin expression was high in gallbladder cancer(67%), while majority of the chronic cholecystitis (94%) and xanthogranulomatous cholecystitis (91%) cases retained positive E-cadherin expression., e-cadherin is a prognostic factor for non-small cell lung cancer, The expression of E-cadherin in invasive ductal carcinoma and carcinoma in situ was significantly higher than that in invasive lobular carcinoma., DDB1 modulates the function of APC/C(Cdh1) in a manner independent of the Cul4-DDB1 complex, provide new evidence that HAb18G/CD147-mediated cell-cell contact confers anoikis resistance in an E-cadherin-dependent manner, Low expression of E-CD and high expression of Snail are related to the advanced stage, and poor prognosis in colorectal cancer patients., impaired down-regulation of E-cadherin and beta-catenin, along with Wnt/beta-catenin signaling pathway activation during the window of implantation, might be one of the potential molecular mechanisms of infertility in patients with endometriosis., Combined vorinostat and bortezomib therapy significantly decreased esophageal cancer epithelial-mesenchymal transition via E-cadherin up-regulation., ZEB1/BRG1 as a new transcriptional mechanism regulating E-cadherin expression and epithelial-to-mesenchymal transdifferentiation, Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress, DDR1 can increase the stability of cell surface E-cadherin and promote MDCK cell aggregation, which may be mediated through the formation of DDR1/E-cadherin complexes., Loss of E-cadherin expression is associated with non-muscle-invasive bladder cancer., p140Cap immobilizes E-cadherin at the cell membrane and inhibits EGFR and Erk1/2 signalling, blocking scatter and proliferation of cancer cells., Novel heterozygous 2275G>T mutation(exon 14) of CDH1 gene detected in Iranian family with hereditary diffuse gastric cancer. The nonsense mutation generates premature stop codon(position 758)with truncated E-cadherin protein lacking cytoplasmic region., Elevated levels of serum E-cadherin is associated with late-stage colorectal carcinoma and familial adenomatous polyposis., Reduced E-cadherin or beta-catenin negative expression relates to dedifferentiation and progression of nonsmall cell lung cancer, Different expression patterns of E-cadherin and p120-catenin proteins can be helpful to distinguish infiltrating lobular carcinoma from ductal carcinoma of the breast., individual cell movement, asymmetric colony expansion, Rho-associated kinase, and E-cadherin all influence embryonic stem cells clonogenicity, and provide additional guidance for improvement of clonogenic assays, up-regulating expression of endogenous E-cadherin in breast cancer can inhibit proliferation, promote apoptosis, decrease mobility, and thus inhibit tumor growth in vivo., Results suggest that CDH1 gene methylation and H pylori infection are frequent events in samples from Brazilian patients with chronic gastritis and reinforces the correlation between H. pylori infection and CDH1 inactivation in early gastric tumorigenesis, The E-cadherin-catenin complex is the factor indicative of metastasis and disease progression in gastric cancer., The study objective was to assess changes in the expressions of E-cadherin and alpha-, beta- and gamma-catenin proteins in pancreatic duct carcinoma in correlation with clinicopathological parameters, lymph node involvement and distant metastases., PAS staining instead of H&E on CDH1 mutation-positive prophylactic gastrectomy specimens may increase the detection rate of adenocarcinoma while reducing screening time., Stromal CD10 expression and relationship to the E-cadherin/beta-catenin complex in breast carcinoma, Nuclear localization of E-cadherin in basal cell carcinoma is also associated with aggressive tumour features, in the 123 TNBC cases, the prognosis of patients with an E-cadherin-negative expression was significantly worse than that of E-cadherin-positive patients (P=0.0265), especially for those in clinical stage II (P=0.002)., loss of E-cad expression in gastric cancer correlated with peripheral blood micrometastasis, lymph node metastasis, TNM stage, and lymphatic invasion., Both P16 and CDH1 had different expression levels in tumor tissues compared to the adjacent normal tissues., Our study suggests that E-cadherin down-regulation may lead to enhancer of zeste homologue 2-mediated invasion and metastasis., the potential involvements of E-cadherin and beta-catenin in meningioma, Data report that a nuclear-localized portion of the stress-activated kinase JNK is degraded by the APC/C(Cdh1) during exit from mitosis and the G1 phase of the cell cycle., We suggest that COX-2 pathway reduces membranous E-cadherin expression in bladder transitional cell carcinoma, TGF-beta1 and E-cadherin are closely associated with the metastasis of ovarian carcinoma., the motility of E-cadherin within, and away from, the cell surface are not exclusive or independent mechanisms and there is a fine balance between the two which when perturbed can have dramatic effects on the regulation of Adherens Junctions, E-cadherin gene promoter hypermethylation was associated with low or absent expression of E-cadherin. Loss of E-cadherin protein may contribute to aberrant localization of beta-catenin., Expression of E-cadherin in endometrium and fallopian tubes from infertile women., Reduced expression of E-cadherin is associated with bronchioloalveolar carcinoma., Overexpressions of nuclear E-cadherin is associated with non-small cell lung cancer., Results suggests that the -160 AA genotype of human CDH1 is associated with an increased risk of gastric cancer in Oman., IGF2*A allele and CDH1*C allele were correlated with leiomyoma susceptibility, which may be associated with leiomyoma development., Analyses of CDH1 methylation suggested a significant difference between hypermethylated and non-hypermethylated samples, with a positive association between the -160 A allele and hypermethylation., Promoter methylation of DAPK1, E-cadherin and thrombospondin-1 in de novo and therapy-related myeloid neoplasms., Data indicate that P-cadherin but not E-cadherin is important for maintaining adherens junctions in DU145 and MCF10A cells., Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1., induction of E-cadherin expression by small activating RNA leads to suppression of migration and invasion of PC3 prostate cancer cells., In lung carcinomas dysadherin expression seems to reflect tumour aggressiveness and may be considered a positive marker of poor prognosis when considered alone or/and in combination with down-regulation of E-cadherin., E-cadherin may be involved in the pathogenesis of chronic rhinosinusitis with nasal polyps and correlated with disease severity., The majority of patients with germline CDH1 mutation have foci of noninvasive or invasive gastric cancer by middle age., the sequential actions of the APC-c(Cdc20) and APC-c(Cdh1) ubiquitin ligases regulate the clearance of Mps1 levels and are critical for Mps1 functions during the cell cycle in human cells., These results indicate that examination of CSE1L and E-cadherin distribution in colorectal epithelium glands may be valuable for evaluating the malignance of colorectal disease., Hypermethylation of E-cadherin is associated with recurrence of bladder cancer., PLEKHA7 is a cytoplasmic component of the epithelial adherens junction belt, distinct from ZO-1 and E-cadherin, Suggest that TC21 promotes cell motility and metastasis by regulating the expression of E-cadherin and N-cadherin in hepatocellular carcinoma and is associated with tumor progression and poor prognosis in HCC., E-cadherin proteolyis and nuclear translocation associates with aggressive foci growth only in the peritoneal microenvironment in colorectal cancer., Loss of E-cadherin expression may be a marker of plasmacytoid and signet ring cell differentiation in urothelial carcinoma., E-cadherin expression in nasopharyngeal carcinoma is negatively correlated with the numbers of the lymph node metastases and the metastasis distance., Mutational analysis of E-cadherin, in synovial sarcomas, CDH1 gene mutation is not associated with hereditary diffuse gastric cancer., metalloproteinase MMP-2 and MMP-9 -to-E-cadherin ratio has an effect on lymphangiogenesis and lymph node metastasis in prostate cancer, plakoglobin and E-cadherin recruit plakophilin3 to the cell border to initiate desmosome formation, Loss of E-cadherin is associated with colorectal carcinoma., A negative correlation is found between Ezrin and E-cadherin expression in nasopharyngeal carcinoma tissues. Ezrin and E-cadherin are closely related to clinical staging and cervical lymph node metastases., These results provide evidence that E-cadherin is expressed in a proportion of invasive lobular carcinoma of the breast, however, unlike ductal carcinoma, its expression seems to be of limited significance., Hypermethylation of the CDH1 gene, resulting in low E-cadherin expression in endometrial carcinoma is associated with clinicopathological progress and the 5-year overall survival rate., rs16260 overall genotype frequencies in cleft palate only groups were significantly different with controls and rs16260 AA genotype significantly increased risk of CPO by 5.90-fold, providing 1st evidence of CDH1 genetic variation in etiology of CPO., ECAD inhibits Smad3/2 phosphorylation by recruiting RhoA to p120-ctn at the p120-ctn binding domain, whereas the loss of ECAD due to cadherin switching promotes the up-regulation of TGFbeta1 and its target genes, and facilitates liver fibrosis., Potentially pathogenic germline CDH1 mutations in women with early-onset or familial lobular breast cancer are at most infrequent., Data show that E-cadherin and alpha-catenin were predominantly expressed in the cell membranes, whereas beta- and gamma-catenin were found both in the cell membrane and cytoplasm., claudin-1 has anti-apoptotic effects, and is involved in the regulation of the expression and subcellular localization of beta-catenin and E-cadherin in MCF-7, but not T47 D cells, CTGF downregulated the expression of E-cadherin through activation of the nuclear factor-kappaappa B (NF-kappaB) pathway., findings show that p53 has an important role in the progression from serous borderline ovarian tumors to invasive carcinomas. In addition, our findings suggest that downregulation of E-cadherin by the PI3K/Akt pathway contributes to this progression, GLI1-upregulated MUC5AC interfered with the membrane localization of E-cadherin, leading to decreased E-cadherin-dependent cell-cell adhesion and promoting the migration and invasion of pancreatic ductal adenocarcinoma cells., Galpha(12) binds to p120(ctn) and modulates its phosphorylation status through a Rho-independent mechanism. Galpha(12) emerges as an important regulator of p120(ctn) function, These data provide novel insights into the tumor-suppressor function of E-cadherin, which contributes to the suppression of c-Jun protein translation and transcriptional activity., Data show E-cadherin molecular dynamics in vivo following perturbation of integrin signaling by inhibiting focal adhesion kinase (FAK) and Src., The epigenetic change in E-Cadherin and Cyclooxygenase-2 is associated with chronic periodontitis., Aberrant methylation around gene promoter region may play an important part in down regulation of E-cadherin in nasopharyngeal carcinoma., p38 maintains E-cadherin expression by suppressing TAK1-NF-kappaB signaling, thus impeding the induction of epithelial-to-mesenchymal transition in human primary mesothelial cells., E-cadherin is a useful prognostic marker for ovarian clear cell adenocarcinoma patients, and paclitaxel-based chemotherapy can improve survival among patients with positive E-cadherin immunoreactivity., Foxo3a suppression of urothelial cancer invasiveness through Twist1, Y-box-binding protein 1, and E-cadherin regulation., low expression of E-cadherin contributes to the vigorous growth and transforming ability of leukaemic cells, Dsg3, as an up-stream regulator of Src activity, helps regulate adherens junction formation through its interaction with E-cadherin, There is no association between the CHD1 gene 3'-UTR C/T polymorphism and nephrolithiasis in our population., Significantly lower distribution of E-cadherin was seen in interstitial cystitis/painful bladder syndrome bladder tissue compared to control patients, these data demonstrate that HDAC1 is a major repressive enzyme for E-cadherin expression as well as HDAC inhibitor-mediated anti-invasiveness., Substrates are recruited to the Anaphase-promoting complex by binding to a bipartite substrate receptor composed of Cdh1 and Doc1., Brain metastases originating from lung adenocarcinoma and small cell lung cancer were significantly associated to E-cadherin genetic changes., Variant genotypes of the -160C>A polymorphism were associated with significantly decreased gastric cancer risk among Asians., E-cad could enhance adhesion and inhibit proliferation of human breast carcinoma cells through a pathway involving beta-cat and cyclin D1., E-cadherin appears to be a strong predictor of N stage in CRC and should be considered in pre-operative and post-operative management of colon and rectal cancer patients., Combined dysadherin-positive expression and E-cadherin-negative expression may be valuable information for predicting aggressive tumor behavior of differentiated-type gastric carcinoma with submucosal invasion, Reduced levels of E-cadherin protein observed in nasopharyngeal carinoma may play an important role in invasion and metastasis., Study shows that nuclear PTEN interacts with APC/C, promotes APC/C association with CDH1, and thereby enhances the tumor-suppressive activity of the APC-CDH1 complex., Data show that miR-495 expression was directly modulated by transcription factor E12/E47, and promotes oncogenesis via downregulation of E-cadherin and REDD1., The expression of vascular endothelial growth factor C in ovarian cancer was related to matrix metalloproteinase-2 and E-cadherin., Germline CDH1 mutation can be cosegregated with ILBC in the absence of DGC., in patients with gastric caancer, expression of E-cadherin and that of Slug were associated with tumor properties, including lymph node metastasis, stage, lymphatic invasion, and venous invasion, as well as with prognosis, Hakai mediates E-cadherin ubiquitination and degradation triggered by Slit-Robo signaling during colorectal epithelial cell carcinogenesis., the loss of E-cadherin itself may contribute to dysregulated PI3K/Akt signaling through its effects on PTEN., Nuclear translocation of E-cadherin might contribute to ovarian folliculogenesis or granulosa/stromal cell differentiation., This study demonstrates that ataxin-1 occupies the promoter region of E-cadherin in vivo and that ataxin-1 activates the promoter in a CtBP2-mediated transcriptional regulation manner., activated STAT3 signal may associate with Twist and E-cadherin expression and mediate HCC invasiveness and metastasis., A reduction in the expression of E-cadherin was observed in vulvar squamous cell carcinoma, Data suggest that SDF-1 down-regulates the E-cadherin/beta-catenin complex expression in HT29 cells by decreasing mRNA synthesis and increasing beta-catenin phosphorylation., The CDH1 gene was screened for mutations in well-characterized, Finnish, high-risk hereditary breast and/or ovarian cancer individuals., Kras(G12D) allele promotes metastasis in pancreatic cancer cells partly through the downregulation of E-cadherin., Fyn, a member of Src family tyrosine kinases, plays a critical role in mediating TGF-beta1-induced down-regulation of E-cadherin in human A549 lung cancer cells., Our data demonstrate that PIK3CA is a mediator of collagen I-induced down-regulation of E-cadherin., expression of E-cadherin was shown to be a predictor of response to trastuzumab-based treatment for HER2-overexpressing carcinomas, CDH1 mutation are associated with signet ring cell adenocarcinoma of the stomach., The expression of E-cadherin was positively correlated with differentiated degree and lymphatic metastasis., These results suggested that the 3'-UTR +54C/T polymorphism in CDH1 may be a marker for genetic susceptibility of cancer., Down-regulation of E-cadherin and the up-regulation of nuclear beta-catenin expression might be crucial steps during tumour progression of tonsillar carcinomas., There was a positive correlation between STAT3 and vimentin expression and a negative correlation between STAT3 and E-cadherin in colon cancer., germline variants in the CDH1 gene contribute to a predisposition to the development of primary gastric diffuse large B-cell lymphomas., Single nucleotide polymorphisms in the CDH1 gene promoter is associated with development of hepatocellular carcinoma., These results suggest that CDH1-347 polymorphisms are associated with increased risks of oral cancer, and may be a predictive factor for tumor lymph node metastasis., These findings show an important role for p53 in the progression of serous borderline ovarian tumors to an invasive carcinoma, and suggest that downregulation of E-cadherin by DNMT1-mediated promoter methylation contributes to this process., High E-cadherin is associated with metastatic lymph nodes of esophageal squamous cell carcinoma., Cancerous tissues from 30 patients with HPSCC were examined for LOH in 4 tumor suppressor genes (TSGs) (p16, Rb, E-cadherin, and p53) at loci 9p21, 13q21, 6q22, and 17p13, respectively, using microsatellite markers amplified by polymerase chain reaction., APC/CCdh1 is a master G0/G1 regulator and involved in differentiation and development processes. (Review), Our results indicate that the cadherin switch alters through progression of ovarian high-grade serous carcinoma ., These results indicate that PIPKIIbeta-mediated PI(4,5)P(2) signaling is important for E-cadherin upregulation and inhibition of cellular motility induced by VDR activation., Loss of E-cadherin is associated with triple-negative breast cancer., MMP20 may influence ameloblast developmental progression through hydrolysis of cadherin extracellular domains with associated release of transcription factor(s)., Data suggest that SPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK are potential prognostic markers in colorectal cancer., CDH1 polymorphisms are associated with epithelial E-cadherin expression contributor to airway remodelling and lung function in asthma., E-cadherin has a role in antimigratory and antiinvasive efficacy of silibinin in prostate cancer cells, Among patients undergoing pancreaticoduodenectomy for pancreatic ductal adenocarcinoma, partial loss of tumoral E-cadherin expression is an independent predictor of poor outcome, Activation of epidermal growth factor receptor promotes squamous carcinoma cell migration and invasion via inducing epithelial mesenchymal transformation-like phenotype change and matrix metallproteinase-9-mediated degradation of E-cadherin, Data suggest that CDH1 -160C>A gene polymorphism may contribute to increased risk of gastric cancer among Caucasians[meta-analysis], When both E-cadherin and beta -catenin expressions were reduced, there was a significant unfavourable prognosis., Corticotroph tumour progression was associated with reduced expression of the epithelial marker E-cadherin., The deubiquitinase USP37 binds CDH1 and removes degradative polyubiquitin from cyclin A. USP37 was induced by E2F factors in G1, peaked at G1/S, and was degraded in late mitosis. Phosphorylation of USP37 by CDK2 stimulated its full activity., the role of the C-160A single-nucleotide polymorphism (SNP) of CDH1 in susceptibility to gastric cancer, these findings show that epithelial-mesenchymal transition and its down-regulated expression of E-cad circumvent breast cancer dormancy in part by facilitating beta1 integrin expression necessary for metastatic outgrowth., elevation of E-cadherin, a cell adhesion molecule and suppression of beta-catenin, a proto-oncogene have been observed in presence of CaSR agonists whereas reverse effect has been seen in presence of CaSR antagonist, The A allele of the CDH1 -160 C/A polymorphism confers a decreased stomach cancer risk in Asians but not in Caucasians., No association was found between E-cadherin immunoreactivity and nodal metastasis in oral tongue squamous cell carcinoma., These data suggest that loss of E-cadherin expression is associated with increased lymhogeneous metastasis of HNSCC., These findings suggest that hepatitis C virus core protein could play a role in hepatocellular carcinoma at least in part by altering the methylation status of CDH1 promoter in hepatocytes., E-cadherin expression in adenocarcinoma cells is regulated by slug., In the current study of patients with tongue cancer, decreased E-cadherin and increased vimentin were found in spreading tumor satellites, Abnormal expression of E-cadherin, beta-catenin, Wnt-1 was observed., although genetic loss of Brca1 and E-cadherin are infrequent in breast cancer, they are down-regulated at the transcriptional level by CtBP1 expression., Data suggest a critical role of EZH2 in the control of cell invasionand/or metastasis by forming a co-repressor complex with HDAC1/HDAC2/Snail to repress E-cadherin., The results uncovered a novel function of Rack1 in maintaining the junctional homeostasis of intestinal epithelial cells by regulation of the Src- and growth factor-induced endocytosis of E-cadherin., H1 and PAR2 receptors enhance delivery of immune-competent cells and molecules by interrupting E-cadherin adhesion in lung epithelial cells., Results sugggest that histone deacetylation of E-cadherin (CDH1) and downregulation of miR-373, together with the hypermethylation of CDH1 by hepatitis B virus-encoded X antigen, HBx, may be important for the understanding of HBV-related carcinogenesis., Suppression of E-cadherin function drives the early stages of Ras-induced squamous cell carcinoma through upregulation of FAK and Src., E-cadherin-mediated cell-cell contact directly regulates the Hippo signaling pathway to control cell proliferation., We confirmed the association between ulcerative colitis and CDH1., Data suggest that the TBX2/NRAGE complex protects cells against anoikis by downregulating p14ARF, representing a novel pathway for the regulation of anoikis by epithelial-to-mesenchymal transition and E-cadherin., E-cadherin was decreased by EGF, but increased by luteolin and quercetin., Cas proteins do not affect E-cadherin transcription, but rather, BCAR1 and NEDD9 signal through SRC to promote E-cadherin removal from the cell membrane and lysosomal degradation., The Cells lacking Cdh1 have been shown to accumulate deoxyribonucleic acid (DNA) damage, suggesting that it may play a previously unrecognized role in maintaining genomic stability., Data show that CD99 combined with E-cadherin/beta-catenin and CD10 can be used as a relatively specific expression profile of SPTs., This is the first report of CDH1 germline truncating mutations in Japanese patients with familial gastric cancer., Data suggest that regulation of E-cadherin expression in proximal tubule cells involves TGFb1IRS2FoxO3a pathway, Expression of E-cadherin is downregulated, and expression of P-cadherin is upregulated in oral mucosa of mucous membrane pemphigoid (MMP), which may be involved in the pathogenesis of MMP., Results suggest that decreased E-cadherin and increased MMP-2 may be associated with the capacity of GCSCs to metastasize., Cath-D and E-Cad essays may useful in identifying neck lymph node involvement., CDH1 gene promoter methylation may lead to aberrant expression of E-cadherin and beta-catenin in colonic carcinoma, and may play an important role in promoting tumor invasion., TGF-beta1-induced activation of Smad3 is the critical step for the uPA upregulation and E-cadherin downregulation, Data show that EphB receptors interact with E-cadherin and with the metalloproteinase ADAM10 at sites of adhesion., E-cadherin is effectively restricted to supporting cell (SC)-SC junctions in human and murine vestibular epithelia, Results demonstrate that the increase in E-cadherin mobility is constitutively altered by the presence of CAR at FLCARMCF7 cell junctions., E-cadherin,alpha-dystroglycan and beta-dystroglycan levels were decreased in the oesophageal primary tumour samples, despite the presence of normal levels of dystroglycan mRNA., Nuclear translocation of beta-catenin synchronized with loss of E-cadherin in oral epithelial dysplasia with a characteristic two-phase appearance, Ect2 is subject to proteasomal degradation after mitosis, following ubiquitination by the APC/C complex and its co-activator Cdh1, Dietary intakes of folate, vitamins B2, B6, B12, and methionine were not associated with likelihood of promoter methylation of E- cadherin, p16, and RAR-beta2., study presents evidence that in the cadherin-catenin complex alpha-catenin contributes to the binding strength of another catenin, p120, to the same complex; data suggest that alpha-catenin-p120 contact within the cadherin-catenin complex can regulate cadherin trafficking, Downregulation of E-Cadherin enhances proliferation of head and neck cancer through transcriptional regulation of epidermal growth factor receptor, Low E-cadherin is associated with metastasis in colorectal cancer., Our findings suggest further investigation into the prognostic role of E-cadherin in pediatric Colorectal adenocarcinoma, E- and N-cadherins are expressed at the surface of human beta-cells and that these adhesion molecules are involved in the maintenance of beta-cell viability, PLGA was successfully confirmed to support parotid gland acinar cells to form more post-confluence structure by enhancing E-cadherin expression., Certain CDH1 gene promoter -160 C > A and -347 G > GA variants might affect the susceptibility of colorectal cancer., E-cadherin/beta-catenin complex and the epithelial barrier, there are correlations between beta-catenin and TNM stage of colorectal cancer; there are greater amounts of beta-catenin in patients with deeper invasion of the tumor in colon layers, lymph node involvement as well as in patients with distant metastasis, Study concludes that Smad3 regulates, at the transcriptional level, miR-200 family members, which themselves regulate ZEB1 and ZEB2, known transcriptional repressors of E-cadherin, at the posttranscriptional level in a TGF-beta-independent manner., p120 dynamically regulates Rho-GTPase activity at the E-cadherin complex through transient interaction with several of its up- and downstream effectors, including ROCK1, results showed that NOTCH1 affected skin cancer cell motility by changing the expression of E-cadherin, PIPKIgamma and phosphatidyl inositol phosphate pools at nascent E-cadherin contacts cue Exo70 targeting and orient the tethering of exocyst-associated E-cadherin, Loss of E-cadherin is associated with invasion in esophageal cancers., E-cadherin is extensively expressed by oropharyngeal squamous cell carcinoma, even the non-keratinizing type, but our results suggest that cadherin expression may not be a predictor for nodal or distant metastasis in these tumors., Cholangiocarcinoma cell lines express E-cad and beta-cat but with different localizat- ion patterns., E-cadherin nuclear staining is useful in distinguishing between adult granulosa cell tumors and ovarian adenocarcinomas or carcinoid tumors, Loss of E-CD expression is an early event in lobular neoplasia of the breast., The regulation and role of E-cadherin during melanoma development is the focus of this review. [review], The E-cadherin expression was reduced to negativity in advanced stages of gastric carcinoma., The combination of E-cadherin and Ki67 status might be a useful prognostic marker indicating the need for adjuvant chemotherapy in Stage II TNBC patients., This study finds a new mechanism that miR-9 utilizes to decrease E-cadherin expression and inhibit melanoma progression, upregulation of connexin 43 in glioma stem cells inhibited their capacity of self-renewal, invasiveness, and tumorigenicity via modulation of E-cadherin., Membranous E-cadherin immunostaining and cytoplasmic COX-2 expression were observed in 74.3% and 68.6% of cases respectively., examined integrin beta(1) , ECAD and rac1 expression in SCLC and analyzed the prognostic value of these markers, studies uncover a cell-cycle-independent function of Cdh1, establishing Cdh1 as an upstream component that governs Smurf1 activity, Snail1 enhances the binding of Akt2 to the E-cadherin (CDH1) promoter and Akt2 interference prevents Snail1 repression of CDH1 gene, CRYAB functions to suppress nasopharyngeal carcinoma progression by associating with the cadherin/catenin adherens junction and modulating the beta-catenin function., Loss of decorin and E-cadherin accelerated colon cancer cell growth and invasion in Dcn(-/-) mice., The regulation, function, and implications of E-cadherin expression in these central orchestrators of the immune system., The up-regulation of Ezrin and Moesin and the down-regulation of E-Cadherin were associated with the invasion and metastasis of papillary thyroid carcinoma., In senescent cells, the DNA damage response induces proteasomal degradation of G9a and GLP, histone methyltransferases, through Cdc14B- and p21(Waf1/Cip1)-dependent activation of APC/C(Cdh1) ubiquitin ligase., Differential expression of E-cadherin has an important role in pathogenesis of endometriosis., E-cadherin is necessary for localization of DLG1 but not phosphorylated MEK2 to the midbody ring during cytokinesis., genetic association studies in Han Chinese population, The data demonstrate that Cdc6 acts as a molecular switch at the E-cadherin locus, linking transcriptional repression to activation of replication, the roles of STAT3 in colorectal cancer epithelial-mesenchymal transition and in STAT3-induced down-regulation of E-cadherin, E-cadherin could be upregulated by the suppression of ZEB1 transcriptional repressor by miRNAs in vivo, Epigenetic regulation is a mechanism through which tumor cell colonization of metastatic sites occurs as E-cadherin-expressing cells arise from E-cadherin-deficient cells., Compared with conventional carcinomas, serrated adenocarcinomas showed significantly reduced membranous E-cadherin., CDH1 promoter methylation is associated with triple-negative breast cancer., The combination of a decrease of E-cadherin and an increase in vimentin might be a valuable survival indictor in cervical squamous cell cancer., E-cadherin genetic screenings performed in low-risk areas for gastric cancer identified a higher frequency of CDH1 germline mutations., Negative/low HER2 expression alone or combined with E-cadherin positivity is predictive of better prognosis in Tunisian patients with breast carcinoma., Hakai dimerization allows the formation of a phosphotyrosine-binding pocket that recognizes specific phosphorylated tyrosines and flanking acidic amino acids of Src substrates, such as E-cadherin, cortactin and DOK1., Data suggest that TGF-beta, TGF-betaR1, TGF-betaR2, Smad4, pSmad2/3, and E-cadherin are closely related to tumor-node-metastasis (TNM) stage of colorectal cancer (CRC)., The reduced expression of E-cadherin and beta-catenin and EGFR over expression seems to be correlated with tumor differentiation and tumor progression than tumor invasion and tumor proliferation., Associations between RASSF1A and CDH1 methylation levels and clinico-pathological parameters manifested various levels of RASSF1A and CDH1 promoter methylation., Loss of E-cadherin is associated with liposarcoma., E-cadherin inhibits nuclear accumulation of Nrf2 and Nrf2-mediated gene transcription by its interaction with Nrf2; findings imply that chemoresistance of cancer cells upon the loss of E-cadherin might be associated with Nrf2, Both membranous and cytoplasmic localization of high E-cadherin staining were associated with lymph node metastasis in nasopharyngeal carcinoma, E-cadherin can act as a central modulator of the cell biological phenotypes and a potential prognostic marker in Colorectal cancer., CDH1 polymorphisms can contribute to the etiology of premalignant skin lesions in people chronically exposed to arsenic in drinking water, and that this gene may be a factor in individual susceptibility to cutaneous diseases., Our results suggest that endogenous PAI-1 suppresses expression of E-cadherin and differentiation in PAC cells in vitro, supporting its negative impact on tumor prognosis., TWIST may act upstream of E-cadherin, which can indirectly regulate the expression levels of beta-catenin in bladder cancer., the association between CDH1 -C160A genetic polymorphism and colorectal cancer susceptibility, The modifications of E-cadherin by O-GlcNAcylation and lack of pro-region processing represent novel mechanisms for rapid regulation of cell surface transport of E-cadherin in response to intoxication., Snail interacted with G9a and recruited G9a and DNA methyltransferases to the E-cadherin promoter for DNA methylation., E-cadherin expression was present in 100% of cases of both adenocarcinomas and adenomas, with prevailing strong membranous immunoreactivity and no differences between protein expression in tumors and normal mucosa., Results show that the adipocytokines and glucocorticoid metabolism-related genes are overexpressed in colorectal adenocarcinomas, and expression of these genes is associated with the downregulation of E-cadherin mRNA., Data indicate that up-regulation of Slug was significantly correlated with a higher tumor stage and the E- to N-cadherin switch in bladder cancer cells and tissues., APC/C(Cdc20) or APC/C(Cdh1) complexes regulate RAP80 stability during mitosis to the G(1) phase, and these events are critical for a novel function of RAP80 in mitotic progression., Data suggest that pulmonary metastasis is corrected with levels of Geminin, cleaved caspase-3, CD44, E-cadherin, epidermal growth factor receptor, and CD204 in cancer cells within permeated lymphatic vessels., E-cadherin gene polymorphism rs4783689 was marginally associated with endometriosis in the Japanese population, by promoting EGFR internalization, reggie-1 restricts EGFR signaling involved in E-cadherin macropinocytosis and recycling and regulate adherens junction formation, Deletions and/or microdeletions at both miR-101 genomic loci cause mature miR-101 down-regulation, subsequent EZH2 over-expression and E-cadherin dysfunction, specifically in intestinal-type gastric carcinoma., E-cadherin structural models suitable to predict the impact of the majority of cancer-associated missense mutations, High E-cadherin is associated with invasion and metastasis of gastric cancer., The down-regulation of E-cadherin, as modulated by the methylation of CDH1, may contribute to nerve invasion, lymphatic and distant metastasis in salivary adenoid cystic carcinoma., Slug is expressed markedly higher while E-cadherin markedly lower in metastatic gastrointestinal stromal tumors., Although the expressions of E-cadherin and N-cadherin appear to be correlated with survival outcomes in bladder cancer, N-E cadherin switch may be a better predicator for postoperative recurrence and cancer-related survival., E-cadherin promoter hypermethylation and intake of local hot salted tea and sun-dried foods are associated with gastric tumors., Activation of E-cadherin induces p120-catenin dephosphorylation, as well as changes in the cadherin cytoplasmic domain., CDH1 methylation was found in 75 of 92 (81.5%) gastric cancer tissues, which significantly correlated with size, growth pattern, differentiation, lymphatic invasion, venous invasion, invasion depth, lymph node metastasis, distant metastasis, E-cadherin was significantly associated with histological grade and alcohol consumption, and beta-catenin was significantly associated with nodal stage, TNM stage, and E-cadherin expression., Our findings suggested that the regulatory function of 4HPR on infiltration of bladder cancer cells T24 is at least partly achieved by regulating the expression of E-Cad., our results indicated that plasma CDH1 levels may serve as a risk marker against gastric cancer and variant genotypes of rs26160 and rs17690554 may contribute to the etiology of diffuse gastric cancer in this study., Growth and proliferation of SKOV-3 cells was efficiently suppressed after knocking-down of E-cadherin expression., The expression changes of TGF-beta1 and E-cadherin may be related to the emergence and the development of glioma., E-cadherin is critical for collective sheet migration and is regulated by the chemokine CXCL12 protein during restitution, preoperative serum E-cadherin concentrations are higher in patients with less differentiated prostate cancer, Snail interacted with Suv39H1 and recruited it to the E-cadherin promoter for transcriptional repression., Histone deacetylase inhibition induced the E-cadherin expression and the proper membrane localization of the E-cadherin/beta-catenin complex, leading to reduced cancer cell migration and invasion., alpha- and beta-catenins may be important in the early stages of phyllodes tumours development, while E-cadherin may be required for malignant development, Rho-GTPase-dependent modulation of cytoskeletal function and downregulation of E-cadherin expression are identified as relevant effectors of the miR-10b-syndecan-1 axis, Twist was expressed significantly more and E-cadherin significantly less in gastrointestinal stromal tumors (GISTs) with metastasis, and expression of both was closely related to metastasis of GISTs., APC/CCdh1 is able to ubiquitylate E2F3A in vitro, and that the degradation of E2F3A is stimulated by Cdh1, but not by Cdc20., The effect of Cdh1 on E2F1 degradation is blocked upon DNA damage., This calpain-mediated proteolysis of E-cad generates the formation of the lymphovascular embolus and is responsible for its unique properties of increased homotypic adhesion, apoptosis resistance and budding., E-cadherin stimulates the synthesis of intervertebral disc matrix macromolecules aggrecan and collagen II through the induction of BMP genes and enhancement of the Smad1/5 phosphorylation., The M4 mutant, which contains N-terminal 1-54 amino acids and the Armadillo repeat domain, was functional in regulating E-cadherin., these findings identified epigenetic silencing of CDH1 in cancer cells might be a new molecular event of multidrug resistance., Data indicate that Rab7 siRNA knockdown causes increased E-cadherin., Specifically, NiCl(2) induces down-regulation of E-cadherin by reactive oxygen species generation and promoter hypermethylation, Downregulation of E-cadherin may be valuable as risk marker for development of multiple tumours in oral cavity and for diagnosis of premalignant fields., Data show that Acinetobacter baumannii transposase Tnp in A549 cells induced DNA methylation of CpG regions in the promoters of E-cadherin (CDH1) gene, whereas the cytoplasmic localization of the truncated Tnp without NLSs did not induce DNA methylation., Investigated the expression of RKIP and E-cadherin in lung squamous cell carcinoma tissue. The rates of positive RKIP and E-cadherin mRNA expression were significantly lower in lung squamous cell carcinoma than in the surrounding normal tissues., Trends in the expression of E-cadherin suggests its involvement in oral carcinogenesis via Wnt pathway dysregulation., these results demonstrate a Fyn kinase-dependent mechanism through which IFNgamma regulates E-cadherin stability and suggest a novel mechanism of disruption of epithelial cell contact, which could contribute to perturbed epithelial barrier function., The aim of the present paper was to evaluate Wwox and TAZ, nuclear effectors of Hippo-related pathways, were involved in E-cadherin expression in bone metastases specimens from breast cancer., Approximately 38% of HDGC families have a CDHI gene mutation., Decreased E-cadherin expression was associated with poor survival in patients with non-small cell lung cancer, especially among Asians. [Meta-analysis], findings show that alpha-catulin is highly expressed in melanoma cells; expression of alpha-catulin promoted melanoma progression and occurred concomitantly with the downregulation of E-cadherin and the upregulation of expression of mesenchymal genes, findings suggest that miR-23a regulates TGF-beta-induced epithelial-mesenchymal transition by targeting E-cadherin in lung cancer cells, Transcription initiation arising from CDH1 intron 2 encoded a nove lCDH1a that increases gastric cancer cell invasion and angiogenesis., high intracellular PKCK2 activity confers anoikis resistance on esophageal cancer cells by inducing E- to N-cadherin switching., The expressions of E-cd and alpha-cat are significantly lower in prostate cancer than in benign prostatic hyperplasia, and they are not associated with cancerous metastasis, but negatively correlated with the PSA level in PCa patients., These findings establish a principal biological function of SIRT1 in the modulation of E-cadherin function., A meta-analysis indicated that the -160A allele of E-cadherin provides a higher risk for the development of prostate and urothelial cancers and a protective role for colorectal cancer in an ethnicity-dependent manner., These results provide strong evidence that the methylation status of E-cadherin gene contributes to a reduction in the expression of E-cadherin mRNA, and may play a role in the development and progression of non-small cell lung cancer., impact of cell-cell contact, E-cadherin and EGF receptor on the cellular radiosensitivity, we have demonstrated an association of epithelial E-cadherin expression with stromal histologic features and disease recurrence in phyllodes tumor., invasiveness was significantly correlated to the loss of membranous E-cadherin, as well as to increased ASMA, S100A4, and PDGFRbeta in stromal cells., In the -197 A allele carrier with *1249 CC homozygote of IL17A, the methylation of DAPK and CDH1 increased gradually, but more rapidly, with age., We conclude that determination of E-cadherin expression can be used as an adjunct in selecting patients who may benefit from adjuvant chemotherapy in the presence of otherwise favorable prognostic factors., These findings indicate the existence of a novel E-cadherin-related mechanism by which miR-10b modulates breast cancer metastasis., Our results suggest that Twist was expressed significantly more and E-cadherin significantly less in osteosarcoma with metastasis, E-cadherin cytoplasmic mutations interfere with the binding of key exocytosis-related partners, Loss of E-cadherin is associated with hepatocellular carcinoma., High Slug and low E-cadherin expression in basal-like breast cancer (BLBC) correlated with histological grade, TNM stage, and lymphatic metastasis. Poor prognosis of BLBC is associated high Slug and vimentin expression and low E-cadherin levels., Reduced expression of E-cadherin is associated with ovarian cancer., There is an association between decreased E-Cadherin immunoexpression and tumor recurrence in low-grade and non-muscle invasive transitional cell carcinoma of the bladder., changes in the expression of Snail or E-cadherin might regulate Epithelial-mesenchymal transition development in cholangiocarcinoma, Data indicate that cultured tubular cells (hPTECs) reorganized into patches of cells with homotypic N-cadherin or E-cadherin cell-cell adhesions., Recruitment of histone deacetylases by transcriptional repressors LEF-1 and Slug is responsible for E-cadherin suppression and epithelial-to-mesenchymal transition in cigarette smokers., E-cadherin may serve as an additional diagnostic marker for angiomyolipoma., CDH1 mutation is associated with gastric and breast cancer., CDH1 methylation-positive cervical cancer patients had a 7.8-fold risk for death and a 92.8-fold risk for relapse., Nanog-mediated cell migration and invasion involved its regulation of E-cadherin and FOXJ1., Low cadherin 1 expression is associated with hepatocellular carcinoma invasion., Ezrin, E-cadherin and CD44V6 play an important role in the regulation of growth and meastasis of lung cancer., E-cadherin expression correlated negatively with PMN infiltration, compatible with the notion that E-cadherin is cleaved by PMN-derived elastase, Studies indicate that E-cadherin and versican are involved in cancer epithelial-mesenchymal transitions and metastasis., the loss of CDH1/E2F4 may be associated with worse clinical and pathological findings in mammary ductal carcinoma., E-cadherin expression in nevi is related to the degree of melanocytic maturation., The overexpression of SLUG and TWIST with down-regulation of E-cadherin was characteristic findings in hemangiopericytomas and solitary fibrous tumors, but not in meningiomas., SNAI1 expression was significantly correlated with lower expression of CDH1 in colorectal adenoma., The aim of this study is to evaluate the role of p130cas, E-cadherin, and beta-catenin expression in patients with non-small cell lung cancer., The drug-resistant MCF-7/Adr cells were found to be more invasive/metastatic than their parental control, possibly related to the loss of E-cadherin expression., Loss of SARI expression initiates epithelial-to-mesenchymal transition (EMT), which is visualized by repression of E-cadherin and up-regulation of vimentin in lung adenocarcinoma cell lines and in clinical lung adenocarcinoma specimens., E-cadherin promotor methylation and mutation are inversely related to motility capacity of breast cancer cells., E-cadherin, EMMPRIN and MMP-8 median values were significantly increased in all chronic kidney disease children, as well as in all dialyzed patients versus controls, Key roles of ZEB1 and E-cadherin in the oncogenesis and invasiveness of lung squamous cell carcinoma., Enhanced expression of E-cadherin is associated with the development of cervical neoplasia and cancer., Interaction between alpha6 integrin and E-cadherin drives liver metastasis of colorectal cancer cells through hepatic angiopoietin-like 6., Mapping of cancer foci showed the highest density in the anterior proximal fundus (37%) and cardia/proximal fundus (27%)., Overexpression of NEDD9 correlated with abnormal expression of E-cadherin, beta-catenin and N-cadherin., After exposure to hypoxia, HIF-1alpha protein was up-regulated, both mRNA and protein levels of E-cadherin were down-regulated and MMP-2 was up-regulated, while HIF-1alpha mRNA showed no significant change, The low expression of CD82/KAI1 and E-cadherin was closely related to the invasion, progression and metastasis of non-small cell lung cancer., Elevated plasma soluble E-cadherin expression was involved in the pathogenesis of PID and is useful for the diagnosis of PID., intermolecular interactions are required for Langerhans cell differentiation in the epidermis, Downregulation of E-cadherin was associated with gastric cancer., Results show a role for E- and P-cadherin co-expression in breast cancer progression and highlight the potential benefit of targeting P-cadherin in the aggressive tumours expressing high levels of this protein., the E-cadherin promoter is repressed in cells expressing E6, resulting in fewer E-cadherin transcripts., Oncogenic B-RAF(V600E) signaling induces the T-Box3 transcriptional repressor to repress E-cadherin and enhance melanoma cell invasion., CDH1 missense mutations were found in 4 out of 81 (5%) patients with non-syndromic OFC. This finding opens a new pathway to reveal the molecular basis of non-syndromic OFC. Cancer risk among carriers of these mutations needs to be defined., The high expression of Ezrin and the low expression of E-Cadherin were related to invasion and metastasis in papillary thyroid carcinoma., Report immunohistochemical CDH1 expression in hyperplastic and neoplastic lesions of the prostate gland., The data showed that both fascin and vimentin proteins were significantly overexpressed in cholangiocarcinoma, whereas E-cadherin expression was reduced in cholangiocarcinoma compared with normal tissues., E-cadherin and alpha-catenin down-regulation might be associated with neoplastic transformation in laryngeal tissues and might be regarded as a risk factor for clinical recurrence., Expression of E-cadherin is not associated with malignant progression of brainstem gliomas, unlike beta-catenin and neuronal cadherin., Decreased levels of E-cadherin is associated with lung cancer., Data confirm that E-cadherin and COX-2 expressions are related to OSF. The epigenetic changes presented in patients with chronic inflammation might demonstrate an irreversible destruction in the tissues or organs similar to the effects of cancer., Loss of E-cadherin may be mediated through NF-kappaB-induced Snail upregulation., Snail regulates levels of E-cadherin and desmoglein 2 in oral squamous cell carcinoma cells both transcriptionally and post-translationally., C. albicans significantly decreased E-cadherin mRNA expression & protein production in gingival epithelial cells. IFN-gamma prevented this effect., Dkk-1 inhibited the survival and migration of human PTC cells by regulating Wnt/beta-catenin signaling and E-cadherin expression., E-cadherin gene mutations are associated with gastric cancer., The variants of differentiated cancers with a poorer prognosis (i.e. tall cell and follicular variants of papillary cancer and widely invasive follicular cancers) present reduced intensity of E-CAD expression., The capacity of TFF1 to enhance prostate cancer cell migration/invasion is mediated by transcriptional repression of E-CADHERIN., Negative E-cadherin expression seems to predict unfavourable clinical outcome in patients with advanced-stage serous ovarian cancer, soft tissue leiomyosarcoma patients with the gain of E-cadherin and loss of Vimentin expression represent favorable trend of survival, WT1 binds to the E-cadherin promoter and regulates gene expression in prostate cancer., LSD1 expression was higher, while E-cadherin expression was lower, in colon cancer specimens of high TNM stage and with distant metastasis. Positive LSD1 expression and negative E-cadherin expression were correlated with lower overall survival., Loss of E-cadherin is associated with serous ovarian cancer., sEcad contributes to skin carcinogenesis via association with the HER/IGF-1R-family of receptors and subsequent activation of the MAPK and PI3K/Akt/mTOR pathways., the majority of cervical cancers in the study were E-cadherin positive; no correlation was found between the level of E-cadherin expression and the oxygenation status, these results indicate that in human breast cancer loss of E-cadherin is not causal for EMT and even not a necessity., Increased expression of CD10 in transitional and squamous cell carcinoma (TCC/SCC) tumor and stromal cells, and decreased expression of E-cadherin in TCC tumor cells, are correlated with tumor progression, invasion, and metastasis in human bladder cancer., study found CDH1 somatic alterations exist in all clinical settings and histotypes of gastric cancer and associate with different survival rates, E-cadherin is not a tumour suppressor gene in invasive ductal carcinoma of the breast., The expression of E-cadherin and beta-catenin in pituitary adenoma was significantly downregulated and related to subtype, invasiveness, and postoperative recurrence., In oral squamous cell carcinoma the probability to have or develop metastases was very low when high E-cadherin expression was found in a preoperative sample or when a low podoplanin expression was found, E-cadherin expression is downregulated and is negatively correlated to Long non-coding RNA H19 expression in bladder cancer, Loss of E-cadherin and aberrant beta-catenin expression could be a prognostic factor in patients with small intestinal adeno-carcinomas., Human c-Myc represses E-cadherin at the post-transcriptional level through miR-9., Data indicate that TIMP-2 promotes an anti-tumoral transcriptional profile in lung cancer including upregulation of E-cadherin., The aberrant high expression of beta-catenin and decreased expression of E-cadherin is associated with poor prognosis in nasopharyngeal carcinoma., these results suggest that E-cadherin expression in cancer cells is controlled by a balance between ZEB2 and KLF4 expression levels., We found upregulated miR-200a expression to increase E-cadherin and suppress the Wnt/beta-catenin pathway by targeting ZEB1 and ZEB2 in GA, thus delaying tumor growth in vivo., the CD91/IKK/NF-kappaB signaling cascade is involved in secreted HSP90alpha-induced TCF12 expression, leading to E-cadherin down-regulation and enhanced CRC cell migration/invasion, Loss of E-cadherin is associated with ovarian cancer., Overexpression of delta-catenin reduces the expression of E-cadherin and alters the balance between E-cadherin and p120ctn, which in turn affects the formation of intercellular adhesions and promotes invasion and metastasis in Colorectal cancer., alterations of their expression suggest a role of Dsg3 and gamma-catenin (additionally to E-cadherin/beta-catenin) as biomarkers of malignant transformation risk of oral dysplasia and the biological behavior (aggressiveness) of oral cancer, respectively, Report novel CDH1 germline mutations in Chinese sporadic gastric cancer patients., BRAF(V600E) increases migration and invasion of thyroid cancer cells via upregulation of Snail with a concomitant decrease of its target E-cadherin., E-cadherin 1054del83 transcript is a frequent event in gastric cancer., Down-regulated LIV-1 cells showed significant inhibition of proliferation in vitro and reduction of tumor growth in vivo. Furthermore, E-cadherin expression increased in LIV-1 siRNA expressing Hep-G2., Studies suggest CDH1 mutation for the diagnosis of Hereditary diffuse gastric cancer., Aberrant expression of E-cadherin and integrin beta-1 is closely related to malignant transformation and hydatidiform mole development., A high membrane/cytoplasm (M/C) ratio of E-cadherin expression., show that the Gas2l3 protein is targeted for ubiquitin-mediated proteolysis by the APC/C(Cdh1) complex, but not by the APC/C(Cdc20) complex, and is phosphorylated by Cdk1 in mitosis, E-cadherin alterations are associated with hereditary diffuse gastric cancer., Cadherin alterations are associated with inherited human diseases., The overexpression of EBP50 could inhibit the growth of hepatocellular carcinoma cells and promote apoptosis by modulating beta-catenin, E-cadherin., Data show that TGF-beta1 regulates E-cadherin and vimentin expression through KLF8 pathway., O-GlcNAcylation could enhance ovarian cancer cell migration and reduce the expression of E-cadherin and the formation of the E-cadherin/catenin complex, thereby reducing intercellular adhesion., Data indicate that patients with basal subtype breast cancer and high E-Cadherin expression in their tumors had a poor clinical outcome., HER2 is implicated in mediating the effects of epidermal growth factor (EGF) on Snail, Slug and E-cadherin expression as well as inducing invasiveness of ovarian cancer cells., miRNA-200c inhibited Akt signaling through its effects on E-cadherin and PTEN, resulting in the inhibition of doxorubicin resistance in breast cancer cells., The CDH1 -160C/A polymorphism may constitute an inheritable risk factor for breast cancer in south Indian women., Data indicate that genomic profiling of relapsed CDH1-mutated invasive lobular carcinoma (ILC) featured a high incidence of ERBB2 alterations., Loss of E-cadherin expression is associated with poor response to epidermal growth factor receptor-tyrosine kinase inhibitor treatment in lung cancer., results suggest that reduced expression of E-cadherin is associated with promoter methylation of E-cadherin gene, in addition to providing evidence for the aberrant nuclear localization of E-cadherin in epithelial ovarian carcinoma, Our results establish that the E-cadherin ectodomain-specific mAb DECMA-1 inhibits Ecad(+)/HER2(+) breast cancers by hindering tumor growth and inducing apoptosis via downregulation of key oncogenic pathways, Cx43 and E-cadherin are reduced with non-small cell lung cancer progression, and might be important biomarkers for judging the metastasis and prognosis., The expression of Twist is upregulated, whereas that of E-cadherin is downregulated in ovarian cancer., Data indicate that regulation of Rad17 turnover is through the Cdh1/anaphase-promoting complex pathway in breast cancer cells., We showed that cadherin and nectin in the junctions of A431 cells and human keratinocytes are located in separate clusters., phosphorylation on CRY-box by Polo-like kinase-1 is required for Cdh1-dependent degradation of Cdc20 during somatic cell cycle, High E-cadherin expression is associated with lymphatic vessel invasion in abdominal metastases of breast cancer., The present study examined the expression of AP-2alpha, TIMP-2, MMP-2, MMP-9, and E-cadherin in severe preeclamptic placentas and normal placentas., GnT-III determines E-cadherin-mediated tumor suppression, and GnT-V regulates E-cadherin-mediated tumor invasion., Data indicate that pancreatic (pro)enzymes enhanced expression of beta-catenin and E-cadherin and decreased expression of several epithelial-mesenchymal transition (EMT)-associated genes, such as Vimentin, Snail and Slug., APC(CDH1) targets MgcRacGAP for destruction in the late M phase., CDH1 germline mutations and the hereditary diffuse gastric and lobular breast cancer syndrome, E-cadherin expressing mononuclear histiocytes are likely precursors for multinucleated giant cells in cutaneous granulomas and may play a critical role in disease pathogenesis., activation of AKT plays a role in contactin-1-mediated downregulation of E-cadherin., ELE increased both the protein and mRNA levels of E-cadherin., Suggest that ZEB1 overexpression, associated with E-cadherin and miR-200s downregulation, and the expression of mesenchymal markers might enhance the metastatic potential of undifferentiated endometrial carcinomas., These findings support the potential value of E-cadherin for a supplementary differentiation of molecular subtypes of breast carcinoma, based on the biological significance of its capacity of expression., Combined detection of VM, HIF-lalpha and E-cad plays an important role in predicting the invasion, metastasis and prognosis of patients with ESCC., APC/C(Cdc20), and APC/C(Cdh1) act successively to ensure that the disappearance of licensing inhibitors coincides exactly with a peak of Cdt1 and Cdc6., this study shows that sEcad is a novel candidate protein for drug targeting since it is increased in human and mouse HER2-positive (HER2+) breast tumors, MMTV-PyMT bodily fluids and human cell culture systems., Data suggest that, in tubal pregnancy, fallopian tube mucosa exhibits reduced E-cadherin expression, enhanced beta-catenin expression, and glycogen accumulation; tubal arteries exhibit neovascularization and hyperplasia in tubal pregnancy., High expression of GLI1 dampened expression of E-cadherin and enhanced the expression of Vimentin., The soluble serum E-cadherin levels in breast cancer patients undergoing preoperative systemic chemotherapy have high predictive value., The increased therapeutic efficacy of the PEG-IFNalpha2b plus RBV treatment could be secondary to the inhibition of claudin-1 and E-cadherin cell membrane expression., The abnormal expression of E-cadherin and beta-catenin proteins might be useful in distinguishing vulvar intraepithelial neoplasia from non-neoplastic vulvar squamous epithelium lesions in problematic cases., The expression of E-cadherin and beta-catenin, combined with cytological and architectural analysis, may highlight different immunophenotypes and improve classification of breast carcinomas in situ with mixed pattern., Loss of E-cadherin and beta-catenin with cytoplasmic ALCAM accumulation may play pivotal role in oral cancer development and progression., celastrol treatment restored E-cadherin promoter activity in TGF-beta1-treated cells, Western blotting and real-time reverse transcriptase-polymerase chain reaction demonstrated that these cells had downregulated E-cadherin protein and messenger RNA levels, respectively, methylation of E-cadherin promoter is associated with risk of lung cancer, Data show that miR-148a downregulated vimentin expression and upregulated E-cadherin expression, suggesting that miR-148a inhibited epithelial-mesenchymal transition (EMT), and the SMAD2 gene was identified as the direct and functional target of miR-148a., There was a significantly positive correlation between miR-200a and E-cadherin in epithelial ovarian cancer, We suggest that the down-regulation of E-cadherin in multicentric/multifocal breast cancer is causally connected with the worse prognosis of this tumor type., GLI2 represses E-cadherin gene (CDH1) expression in melanoma cells via distinct mechanisms, enhancing transcription of the EMT-activator ZEB1., CDH-1 expression exhibited a negative correlation with the invasiveness of colon cancer cells., Positive correlations between the expression of E-cadherin and NDRG2 were shown in several colon cancer cell lines as well as in colon cancer tissues., miR-23a inhibits E-cadherin expression in gastrointestinal cancer., expression and subcellular localization of p120-catenin and beta-catenin in oral carcinomas, Suppression of CDH1 transcription is associated with the development and progression of non-small-cell lung cancer., FadA binds to E-cadherin, activates beta-catenin signaling, and differentially regulates the inflammatory and oncogenic responses., SALL4 functions to suppress CDH1 expression and to maintain cell dispersion in basal-like breast cancer., E-cadherin expression in squamous cells is reduced by HD-5, Expression of E-cadherin is significantly associated with tumor location and mortality in patients with oral squamous cell carcinoma., Data indicate that E-cadherin was elevated , and the expression levels of N-cadherin, Vimentin and Twist1 were all decreased in oleanolic acid (OA)-treated cells., Our study demonstrates significantly elevated serum levels of sE-cadherin in women with systemic lupus erythematosus compared with healthy women., TGF-beta2 activated Smad-2/3, serine-threonine kinase (AKT), and extracellular signal-regulated kinase (ERK) signaling, and enhanced expression of beta-catenin as well as N- and OB-cadherin., Low level of E-cadherin expression is associated with breast cancer., Hypermethylation of E-cadherin is associated with gastric cancer., current study showed that the majority of DGC cases demonstrated concurrent CDH1 promoter methylation in tumor tissues and in non-neoplastic mucosa, BCL2 is not involved in lobular breast carcinogenesis and is unlikely to represent an important determinant of tumor development driven by CDH1 inactivation., the CDH1 polymorphism is involved in the etiology of nephrolithiasis, These results indicated a possible effect of SIRT1 and p300/CBP involved in regulating the expression of E-cadherin and MLH1, thus participating in the tumor progression of gastroesophageal junction cancer, CDH1 hypermethylation is associated with triple-negative breast cancers., A novel role for ILK in glioma invasion and metastasis processes via downregulation of CDH1., The knockdown of flotillins dramatically affected N- and E-cadherin recruitment at CCJs in mesenchymal and epithelial cell types and perturbed CCJ integrity and functionality, Susceptible CDH1 genotypes might modulate the development of asthma, especially for children exposed to environmental tobacco smoke., PP6c associates with E-cadherin in adherens junctions and is required to oppose casein kinase-1 to maintain cell surface localization of E-cadherin., No associations were noted between promoter hypermethylation of the CDH1 gene and biological features of the endometrial cancer cases., Epithelial-to-mesenchymal transition status is determined by calculating the ratio of vimentin to E-cadherin, whereby patients are categorized into 3 groups, Gli-1 expression increased markedly, and was closely associated with increased Snail expression and decreased E-cadherin, Poor prognosis for serous ovarian cancer patients with CD44(+)/E-cadherin(-) and CD44(+)/budding(+) tumor cells phenotype, has been revealed, MAD2L2 helps to ensure a robustly bistable switch between APC/C(CDC20) and APC/C(CDH1) during the metaphase-to-anaphase transition, thereby contributing to mitotic fidelity., COX-2 likely functions upstream of NF-kappaB and regulates the expression of E-cadherin via NF-kappaB/Snail signaling pathway in gastric cancer cells., filamin A generates a scaffold for organizing a signaling complex that promotes E-cadherin-mediated cell-cell adhesion and keratinocyte differentiation, Mammosphere formation in breast carcinoma cell lines depends upon expression of E-cadherin., Analysis of gene expression datasets confirmed the association between low PIP4K2B and low CDH1expression., NEDL2 is a novel substrate of APC/C-Cdh1 as cells exit mitosis and functions as a regulator of the metaphase to anaphase transition, High E-cadherin expression was associated with increase in degree of differentiation, and decrease in lymph node involvement in laryngeal squamous cell carcinomas., Our findings suggest that abnormal expression of beta-catenin and E-cadherin occurred frequently in gastric carcinoma and correlated with worse clinical behaviour., Data suggest that E-cadherin (CDH1) screening, in addition to the identification of other risk factors, could be useful for the early detection of gastric cancer (GC) in subjects at risk., Loss of CDH1 induces EGFR expression via phospho-YBX1, which is activated through the AKT signaling pathway., Reduced E-Cadherin expression is associated with nodal metastasis in T1 esophageal squamous cell carcinoma, Low E-Cadherin expression is associated with endometrial cancer., cancer-related mutations in beta-catenin can influence tumor progression by weakening the adhesion of tumor cells to one another through reduced individual Ecad/Ecad bond strength, decorin-mediated inhibition of cholangiocarcinoma cell growth, migration,and invasion and promotion of cell apoptosis might be through regulation of the expression of E-cadherin in vitro., E-cadherin expression was the same in the cholesteatoma matrix in all samples. There were no differences in expression according to the clinical and histological characteristics of the cholesteatomas., Low E-Cadherin expression is a negative prognostic factor of oral squamous cell carcinoma and is likely due to the hypermethylation of CDH1 promoter., E-cadherin protein expression in the cecum was lower in IBS-A compared with controls and associated with longstanding symptoms. E-cadherin was further associated with abdominal pain severity in the IBS group overall, but unrelated to IBS subtype., Inhibition of SALL1 correlates with reduced levels of CDH1, an important contributor to epithelial-to-mesenchymal transition., Low expression of E-cadherin is associated with gastric carcinomas., Positive ZEB-1 expression and loss of E-cadherin expression are correlated with poor prognosis in hepatocellular carcinoma patients., E-cadherin expression was down-regulated in gastric cancer., A more complete study of the prognostic and predictive role of E-cadherin expression in patients with Stage I-II NSCLC will help identify a prognostically unfavorable group of patients who may be given additional treatment in the postoperative period., show that BMP acts prior to and independently of Cdh1 to prime pluripotent cells for mesoderm differentiation, thus helping to reinforce the block to neural differentiation, APC-Cdh1 establishes a stimulus-response relationship that promotes S phase., We have shown that germline CDH1 mutations are associated with early onset of bilateral lobular carcinoma in situ with or without Invasive lobular breast cancer in women without a family history of gastric cancer., Deletion of beta-catenin by siRNA abrogated celecoxib-induced inhibition of MMP9 up-regulation and E-cadherin down-regulation by treatment of PGE2 in A549 cell., A potential important role of alpha4 in control of cell migration and/or invasion via the regulation of E-cadherin expression in bladder urothelial carcinoma., Two novel CDH1 mutations were found. The c.602_603delCT mutation results in a frame-shift and a premature stop at codon 207, and is classified as pathogenic. The functional consequence of the c.1565 + 3insTT mutation was unknown and not as obvious., E-cadherin gene promoter hypermethylation may contribute to increased risk of bladder cancer among Asian populations., Studied the expression of E-cadherin, N-cadherin, TGF-beta1 and Twist protein and investigate its significance in the occurrence and development of prostate cancer., MTA1 promotes tumor invasion by downregulation of E-cadherin, AKAP proteins, most likely AKAP9, maintain the bronchial epithelial barrier by regulating the E-cadherin expression at the cell membrane., In high grade malignant tumors (G1), CDH1 and ITGB1 gene expression was the highest, in G2 and G3 tumors the expression of both genes was gradually lowering, GSTP1 and E-cad did not show any relevant methylation pattern in various endometrial lesions., Low CDH1 expression is associated with laryngeal squamous cell carcinoma., Over-expression of miR-888 reduced the mRNA levels of E-cadherin in MCF-7 side population sphere cells., In conclusion NSCLC cell lines, positive for E-Cadherin,EpCAM and avb6 expression, activate normal fibroblasts through avbeta6/TGFbeta signalling in vitro, and influence both gene expression and response to therapeutic agents., Our meta-analysis indicates that promoter polymorphism and methylation of CDH1 gene may be involved in the development and progression of bladder cancer, WNT/beta-catenin pathway and E-cadherin are important factors in advanced epithelial ovarian cancer., In increased E-cadherin expression., Loss of E-cadherin is associated with breast carcinoma., results suggest that E-cadherin loss promotes SNAI1 expression that controls the aggressiveness of prostate cancer cells, highly sensitive rabbit E-cadherin antibody is the preferred antibody for evaluating ductal carcinomas and for distinguishing ductal versus lobular lesions, and the dual stain was superior to the single E-cadherin stain, Loss of E-cadherin is mediated through inhibition of mTORC1 in lung cancer cells., the summarized analyses of these case-control studies demonstrated that the -160A of the epithelial cadherin gene exhibited no significant association with susceptibility for diffuse gastric cancer, Extensive remodeling of the actin cytoskeleton and focal adhesions accompanies cell fusion and differentiation and appears related to alterations in E-cadherin in trophoblastic cells., Here, we report that infection with HCV derived from pJFH-1 replicon system that mimics natural infection elevates protein levels of DNA methyltransferase 1 and 3b to enhance DNMT activity in human hepatocytes., rs13689 of CDH1 gene is correlated with the syndrome differentiation of gastric cancer., Collectively these data unveil that FBXL19 functions as an antagonist of Rac3 by regulating its stability and regulates the TGFbeta1-induced E-cadherin down-regulation., CDH1 - 160C --> A promoter polymorphism and haplotypes are associated with diffuse gastric cancer., The expression of PRL-3, but not of E-cadherin, was associated with shorter survival of patients. PRL-3 and E-cadherin exhibit interactions in gastric cancer and are involved in the formation of lymph node metastases., In pancreatic adenocarcinoma cells, PAR3 knockdown enhances cell adhesion. We propose this is due to increased expression of E-cadherin, leading to a greater adhesion of free-floating cells to cells bound to the surface via integrins, particularly ITGalphav., MMP-2, MMP-9, and E-cadherin are expressed in the endometrium of infertile patients during the receptive phase of the natural menstrual cycle. However, there is no correlation between the expression of these molecules and the clinical IVF outcomes., E-cadherin and MMP-9 expression at histologically negative surgical margins shows the significance of these markers for prognostic values in oral squamous cell carcinoma patients., CD44 v6 and E-cad expressions had a significant correlation in the NSCLC tissue with lymphatic metastasis., The expression of E-cadherin in OSCC was significantly lower than the control tissues but galectin-9 expression was conversely higher., Ntn-1 induces MMP-12-dependent E-cad degradation via the distinct activation of PKCalpha and FAK/Fyn, which is necessary to govern the activation of ERK, JNK, and NF-KB in promoting motility of umbilical cord blood-derived mesenchymal stem cells., Lack of E-cadherin has been recorded at an early phase in carcinomas., The relatively slow progression of disseminated peritoneal adenomucinosis may be attributable to the smaller number of single isolated tumor cells that lack E-cadherin expression, Low E-cadherin protein expression correlate with an aggressive, malignant phenotype in hepatocellular carcinoma., The disruption of cell adhesion junction by suppression of E-cadherin mediates gallotannin enhanced apoptosis in Hep G2 liver cancer cells., Results indicate that loss of E-cadherin expression is a consequence rather than a cause of c-erbB2-induced epithelial-mesenchymal transition., studies identify Cdh1 as an important regulator of nuclear/chromatin PTEN during mitosis., We found a strong association between the cancer predisposing gene CDH1 and the risk of non-syndromic cleft lip with or without cleft palate in the Polish population, Loss of CDH1 is associated with promotes hepatocellular carcinogenesis., placental expression significantly increased in preeclampsia compared to normotensive pregnancies, Data suggest that E-cadherin can act as a central modulator of tumor cell phenotype and is a potential metastasis marker in cholangiocarcinoma (CCA)., Results showed that three polymorphisms of CDH1 were significantly associated with cancer risk, -160 C>A, -347 G>GA and 3'-UTR +54 C>T. [Meta-Analysis], The sialylation pattern of alpha2beta1 integrin and E-cadherin., E-cadherin augmented DR4/DR5 clustering and assembly of the death-inducing signaling complex, increasing caspase-8 activation in high molecular weight cell fractions., Downregulation of CDH-1 resulting from the epithelial-to-mesenchymal transition may be closely involved in lymph node metastasis in tongue squamous cell carcinoma., E-cadherin and b-catenin immunostaining showed no prognostic value for basaloid and conventional squamous cell carcinomas, Data suggest that macrophages contributed to the decreased expression of E-cadherin by NF-kappaB/Slug protein pathway in hepatocellular carcinomas., Studies indicate that hypermethylation frequencies in lung cancer (LC) tissues were significantly higher than those in normal control tissues, Shh signaling may promote invasion and metastasis of oral squamous cell carcinoma by activating MMP-9 and E-cadherin expression., Declining E-cadherin expression is a possible immunohistochemical predictor of patient prognosis in stage III colorectal cancer., In the present study, with an increasing concentration of metformin, the expression of MMP-9 was downregulated whereas that of E-cadherin was significantly upregulated., E-cadherin and P120 catenin cocktail immunostain can be used to differentiate ductal carcinoma in situ from lobular carcinoma in situ., The methylation of E-cadherin is one of the main reasons for the reduction of E-cadherin expression in ovarian cancer., Down-regulation of NDRG1 in gastric cancer metastatic progression was correlated to E-cadherin and MMP-9., Low E-cadherin expression is associated with gastrointestinal stromal tumor metastasis., lncRNA-EBIC is an oncogenic lncRNA, which can promote tumor cell invasion in cervical cancer by binding to EZH2 and inhibiting E-cadherin expression., CD133 associates with beta-catenin in early placodes, and its continued expression correlates with loss of beta-catenin and E-cadherin from the cell membrane at a time when E-cadherin transcriptional repressors Snail and Slug are not implicated., The loss of membranous E-cadherin with increase in cytoplasmic accumulation in differentiative layers of epithelium through the progression of dysplasia was noted along with up-regulation in VEGF expressions, the present meta-analysis provides further evidence that promoter methylation and -160C/A polymorphism of E-cadherin gene may confer a risk to prostate cancer, our study demonstrated that Nur77 could promote the invasion and metastasis of colorectal cancer cells through regulation of MMP-9/E-cadherin signaling, Results showed that E-cadherin loss disrupts the organization of the cell's actin and microtubule cytoskeletons and modifies its adherence and migration characteristics but is insufficient to induce an epithelial to mesenchymal transition., siRNA knockdown of SMAR1 expression in these breast cancer cells results in a coordinative action of Slug-mediated repression of E-cadherin transcription., Reduced E-cadherin expression indicates a poor prognosis for patients with HCC (hepatocellular carcinoma), and it may have predictive potential for prognosis of HCC patients.[meta-analysis], Data demonstrated that Rab11 regulated E-cadherin expression and promoted colon cancer cell transformation., CCND1 870G/A and CDH1 -160C/A SNPs may contribute to the etiology of colorectal cancer in South Indian population and carriers of the 870A/-160A haplotype have a higher risk for colorectal cancer susceptibility., The rs8049282 SNP of the E-cadherin gene may be a potential molecular marker for the development of primary infertility in northern Chinese women with ovarian endometriosis., Increasing evidence suggested that microRNA mediated E-cadherin expression in the head and neck cancers by directly/indirectly targeting the transcription suppressors of E-cadherin, ZEB1 and ZEB2., E-cadherin may directly regulate gene transcription. [Review], Study demonstrated that reactive oxygen species promote the migration and metastatic growth of ovarian cancer cells via upregulation of HIF-1a and LOX and E-cadherin repression., PLCdelta1 has tumor-suppressive functions in colorectal cancer through E-cadherin induction., Estrogen promotes the invasion of ovarian cancer cells via activation of the PI3K/AKT pathway, downregulation of Ecadherin and upregulation of alphaactinin4., we observed the coordinated loss of E-cadherin (CDH1) and transforming growth factor beta receptor II (TGFBR2) in esophageal squamous tumors., Zonula occludens-1, occludin and E-cadherin expression and organization in salivary glands, Btbd7 contributes to reduced expression of E-cadherin and may be a promising cancer marker in non-small cell lung cancer., Data indicate that E-cadherin ubiquitination consistently increases after depletion of kinesin-like protein KIFC3 or ubiquitin-specific protease USP47., Abnormal CDH1 methylation occurs in high frequencies in ductal breast tumors., results demonstrate that adhesion of beta-cells to E- and N-cadherins is regulated by insulin secretagogues and that E- and N-cadherin engagement promotes stimulated insulin secretion., In this cohort of NPC patients, higher levels of E-cadherin and higher levels of vimentin were associated with worse outcomes, E-cadherin and CD10 in endometrial lesions is not correlated, but reduced expression of both molecules could be critical for progression of endometrial carcinoma, AKR1B10 is a unique enzyme involved in pancreatic carcinogenesis via modulation of the Kras-E-cadherin pathway., deltaEF1 associates with DNMT1 and maintains DNA methylation of the E-cadherin promoter in breast cancer cells., In this meta-analysis, E-cadherin expression predicts the overall survival and tumor metastasis in Asian patients with gastric cancer., This study focused on analyzing the immunoexpression of CK19, vimentin and E-cadherin in a number of 43 differentiated thyroid carcinomas., In this critical review, we describe the clinical management of CDH1 germline mutant carriers providing specific recommendations for genetic counselling, clinical criteria, surveillance and/ or prophylactic surgery., PDGFD, CDH1 and SLIT2 are upregulated in low grade meningiomas and schwannomas compared with healthy tissue., E-cadherin binding is essential for the barrier disruption with the Clostridium botulinum type B hemagglutinin complex, Observed strong association of promoter hypermethylation of CDH1 with Gastric cancer(OR = 12.23) suggesting that epigenetic regulation of CDH1 could play a critical role in the etiology of Gastric cancer., Cdh1 depletion causes increased levels of genomic instability and enhanced sensitivity to DNA-damaging agents., NKX3.1 expression mediate beta-catenin and E-cadherin association and cell migration in prostate cells., low expression in hepatocellular carcinoma, High E-cadherin expression is associated with oral squamous cell carcinoma., MicroRNA-9 has a role in promoting tumor metastasis via repressing E-cadherin in esophageal squamous cell carcinoma, The results of this study support the role of E-cadherin in the pathogenesis of asthma., high osteopontin but low E-cadherin expression can be considered as a negative, independent prognostic factor in patients with locally advanced cervical squamous cell carcinoma, CD148 tyrosine phosphatase promotes e-cadherin cell adhesion., Our results suggest employing this methodology as a complementary approach to evaluate the pathogenicity of E-cadherin missense variants, data suggests that E-cadherin regulates assembly of nectin junctions through alpha-catenin-induced remodeling of the actin cytoskeleton around the cadherin clusters., Octamer-binding protein 4 affects the cell biology and phenotypic transition of lung cancer cells involving beta-catenin/E-cadherin complex degradation, The T-box transcription factor Brachyury promotes renal interstitial fibrosis by repressing E-cadherin expression, Loss of E-cadherin expression is associated with recurrence in gastric cancer., Suggest that loss of PEAK1/E-cadherin may play an important role in carcinogenesis and development of gastric cancer through activating epithelial to mesenchymal transition., TLE1 has a role in regulating epithelial-to-mesenchymal transition in A549 cells through its repressive effect on E-cadherin, The expression of E-cadherin varied with breast carcinoma progression to bone metastasis leading to an epithelial phenotype., Results suggest that, besides their role in mechanical adhesion, loss of E-cadherin expression may contribute to cancer progression by modifying pathways that regulate fundamental processes as oxidative stress, immune evasion and cell metabolism., The E-cadherin intracellular interactome is predominantly independent of cell-cell adhesion., placental level significantly reduced in placenta percreta, epithelial cell-derived periostin exerts tumor-suppressor activities in gastric cancer through stabilizing p53 and E-cadherin proteins via the Rb/E2F1/p14(ARF)/Mdm2 signaling pathway., We examined allelic imbalance (AI) on loci 17p13.1 (TP53), 1p36.1 (RUNX) and 16p22 (CDHI) and microsatellite instability (MI) with BAT26 in 78 patients with gastric cancer, ERbeta1 inhibits the migration and invasion of breast cancer cells and upregulated E-cadherin expression in a Id1-dependent manner., Overexpression of SPRY2 reduced EGF-induced cell invasion by attenuating EGF-induced E-cadherin down-regulation, Exogenous expression of cell surface E-cadherin converts statin- sensitive cells to a partially resistant state implying that statin resistance is in part dependent on the tumor cells attaining an epithelial phenotype, This review focuses on soluble E-cadherin in sera of patients affected by three solid cancers (breast, gastric, and colorectal cancers) and how its levels correlate or not with some cancer parameters, self-renewal versus differentiation of human ESCs (hESCs) in response to Wnt signaling is predominantly determined by a two-layer regulatory circuit involving beta-catenin, E-cadherin, PI3K/Akt, and Slug in a time-dependent manner., the decrease in E-cadherin and/or increase in N-cadherin may be required for BMP4-induced migration and EMT., Serum soluble E-cad level is an independent prognostic factor in Asian breast cancer patients., Cytoskeletal regulation plays in controlling the levels of intra-junctional tension at E-cadherin junctions., this meta-analysis failed to confirm the association between the CDH1 C-160A polymorphism and risk of gastric cancer., Suggest MelanA-negative spindle-cell associated melanoma constitutes a distinct inflammatory phenotype correlated with dense infiltration of CD163 macrophages and loss of E-cadherin., The aim of this study was to investigate immunohistochemically the E-cadherin/N-cadherin "switch" and vimentin expression as markers of epithelial-mesenchymal transition process in tongue oral squamous cell carcinomas., The immunohistochemical expression of E-cadherin and alpha-smooth muscle actin (alpha-SMA) in 15 cases of pleomorphic adenoma of salivary glands, were investigated., Low CDH1 contributes to endometrial cancer progression., alleles of marker rs10431924 of the CDH1 gene are associated with vitiligo, especially in the presence of autoimmune comorbidities, GPC3 and E-cadherin expressions are not independent prognostic factors in CRC., The positive expression of E-cad and anti-apoptosis Bcl-2 protein are negatively related in breast cancer., RhoB depletion reduces cell-cell adhesion and downregulates E-cadherin levels as well as increasing internalized E-cadherin in DU145 prostate cancer cells., CDH1 germline variants are present in early-onset diffuse gastric cancer patients in Chinese population, but they are mainly missense variants with unknown function which are likely associated with lymph node metastasis and survival., Results showed evidence that Wip1 underwent Cdh1-dependent proteolysis during mitosis and sustained Wip1 activity during mitosis, resulting in mitotic delay at the metaphase to anaphase transition., that MAD2B may play an important role in high glucose-mediated podocyte injury of diabetic nephropathy via modulation of Cdh1, cyclin B1, and Skp2 expression, E-Cadherin expression in primary sites positively correlates with E-cadherin from LNM, These findings indicated that increased SUZ12 promote gastric cancer cell proliferation and metastasis partly via repressing KLF2 and E-cadherin transcription., miR-218 and its downstream target Gli2, as well as E-cadherin, participate in the anti-invasion process, spatial polarization of integrin and E-cadherin adhesions in a human pluripotent stem cell colony compete to recruit Rho-ROCK activated myosin II., C6orf106 promotes invasion in NSCLC cells. Finally, C6orf106 upregulates vimentin, and downregulates E-cadherin and P120ctn., Hypermethylation of Integrin alpha4 is associated with Prostate Cancer., The results from the current study indicate that the hypermethylation frequency of E-cadherin in NSCLC is strongly associated withnon-small cell lung carcinoma incidence and it may be an early event in carcinogenesis, EHD2 can inhibit the metastasis of human breast cancer by regulating the epithelial-to-mesenchymal transition markers E-cadherin and N-cadherin., The germline missense mutant CDH1(Q16H) had a pro-invasive cell behavior., It was shown that both E- and N-cadherin mRNA and protein are expressed in the human renal proximal tubule., ABCG2 localizes to the nucleus and modulates CDH1 expression in lung cancer cells, Negative E-cadherin expression in bone and soft tissue sarcomas was correlated with lower 5-year overall survival (OR = 3.831; 95% CI, E-cadherin and CD44 may have a role in the epithelial-mesenchymal transition of bladder urothelial carcinomas, This study shows that TGF-alpha uses common and divergent molecular mediators to regulate E-cadherin expression and cell invasion., findings demonstrate MPP8 and SIRT1 reciprocally regulate each other's function at multiple molecular layers through physical interaction; disruption of MPP8-SIRT1 interaction de-represses E cadherin expression and reduces cell motility and invasiveness suggesting this interplay plays critical role in MPP8- and SIRT1-mediated epithelial-mesenchymal transition, E-Cadherin under-expression is associated with hepatic carcinoma., We demonstrate the potential of common inherited genetic variants to inform patient outcome and show that cdh1's rs9929218 identifies approximately 8% of colorectal cancer patients with poor prognosis., The de-regulation of both of miR-29b/c and DNMT3A leads to the epigenetic silencing of CDH1 and contributes to the metastasis phenotype in gastric cancer., MicroRNA-10b Triggers the Epithelial-Mesenchymal Transition (EMT) of Laryngeal Carcinoma Hep-2 Cells by Directly Targeting the E-cadherin., Nuclear factor I-C regulates E-cadherin via control of KLF4 in breast cancer, To increased E-cadherin expression and decreased Akt phosphorylation., In patients with placenta accreta, extravillous trophoblasts (EVT) closer to the placental-myometrial interface demonstrated less E-CAD staining than those found deeper in the myometrium., expression and promoter methylation status in colon adenocarcinoma, CDH1 hypermethylation is correlated with Helicobacter pylori status, indicating that it plays a more important role in the pathogenesis of Helicobacter pylori-positive gastric cancer, The combined expression of ezrin(high) and E-cad(low) or ezrin(high) and ezrin(c) was more associated with lymph node metastasis and poor prognosis. I, The results of the present study point to a new direction to pharmacologically accelerate corneal re-epithelialization, and should have salient clinical implication., Cyclin B1 could suppress the invasion and metastasis of colorectal cancer cells through regulating E-cadherin expression, which enables the development of potential intervention strategies for colorectal cancer., sE-cadherin performed most favorably from a large panel of serum proteins in terms of diagnostic and predictive potential in curatively treatable PCa., In the cascade of gastric carcinoma development, an association was found with loss of E-cadherin., the expression levels of HIF1a, Snail and Ecadherin were correlated with clinical pathological factors in human ovarian cancer., our results revealed that activation of the P2X7 receptor by ATP promotes breast cancer cell invasion and migration, possibly via activation of the AKT pathway and regulation of E-cadherin and MMP-13 expression., Results suggest a regulatory function of E-cadherin that modulates Nrg1 signaling and promotes Schwann cell myelin formation, knockdown of ILK inhibits glioma cell migration, invasion and proliferation through upregulation of E-cadherin and downregulation of cyclin D1. Our results suggest that ILK may serve as a promising therapeutic target for glioma., Report association between human papillomavirus and Epstein - Barr virus DNA and gene promoter methylation of RB1 and CDH1 in range of cervical lesions., Univariate analyses showed that AR, CDH1 and Ki-67 expression levels were significantly associated with overall survival in triple-negative breast cancer patients., E-cadherin expression was associated with EGFR mutation status and patient prognosis in lung adenocarcinoma patients, E-cadherin and vimentin positive expression was associated with tumor metastasis of oral squamous cell carcinoma, Particulate matter (PM10) downregulates E-Cadherin/beta-Catenin expression., All individuals with a CDH1 mutation had a personal or family history of diffuse gastric cancer. Patients with gastric cancer and germline CDH1 mutations had shorter survival times than patients who met the HDGC criteria but did not have CDH1 mutations., Demethylase recovered CDH1 gene expression may be involved in the apoptosis process. The beta-catenin protein translocated from the nucleus and cytoplasm to the membrane result in inactivation of b-catenin signaling pathway, Suggest ECAD expression as independent prognostic factor in colorectal carcinoma., We concluded that CDH1 contributes to NSCL/P with mainly rare, moderately penetrant variants, and CDH1 haploinsufficiency is the likely etiological mechanism., expression. E-cadherin may play a significant role in the sensitivity regulation of EGFR molecular targeting treatment. E-cadherin may provide important clues for selecting proper EGFR-TKI molecular targeting treatment, ZIP5 knockdown inhibited the proliferation, migration and invasion of ESCC and suppressed COX2, cyclin D1 and E-cadherin expression, which led to the inhibition of cell progression in esophageal squamous cell carcinoma ., SFN inhibited invasion by activating ERK1/2 to upregulate E-cadherin and downregulate CD44v6, thereby reducing MMP-2 expression and activity. E-cadherin is an invasion inhibitor, while CD44v6 and MMP-2 are invasion promoters, Decreased membranous E-cadherin expression and aerogenous spread may be associated with worse disease-free survival., the allosteric regulation of cell surface E-cadherin by p120(ctn) dephosphorylation., Report role of CDH1 mutations in estimates of age-associated risks of gastric and breast cancer., site-specific E-cadherin glycosylation modification can directly modulate E-cadherin mediated cell-cell adhesion, a key pathophysiological event in gastric cancer progression., There were differences in the expression of Nrf2, Keap1, p16 and E-cadherin between different ovarian carcinoma subtypes., CDH1 polymorphism in -347G-->GA was observed to be associated with susceptibility of pancreatic cancer, results indicate Moesin may regulate cell motility through its interactions with MT1-MMP and E-cadherin/p120-catenin adhesion complex and cytoplasmic expression of Moesin correlates with nodal metastasis and poor prognosis of OSCCs, E-cadherins arrange in ordered clusters; the first demonstration of the existence of oligomeric cadherins at cell-cell contacts., CDH1 is reduced in endometriosis., CDH1 and IL1-beta expression dictates FAK and MAPKK-dependent cross-talk between cancer cells and human mesenchymal stem cells, Combined therapy with cytotoxic and anti-VEGF agents was shown to result in a significant increase in the number of cases of normal membrane localization of E-cadherin as compared with control (p = 0.00043) and cytotoxic therapy-alone (p = 0.01) groups, in the NMA cases, none of these factors was statistically significant. In a univariate analysis, neither EGFR nor E-cadherin expression showed a significant impact on disease-free or overall survival., These data show that MTBP aggravates the invasion and metastasis of HCC by promoting the MDM2-mediated degradation of E-cadherin., genetic polymorphisms of CDH1 and CTNNB1 were associated with breast cancer susceptibility and patients' prognosis, Epithelial cells with disrupted E-cadherin gene retain the ability to form cell junctions and apico-basal polarity., In patients with breast infiltrating ductal carcinoma, E-cadherin expression was observed conserved in most of the tumors, 92.5% of cases, PLEKHA7 localization to adherens junctions is E-cadherin and p120 dependent., factor, analysis of ARID1A, CDH1, cMET and PIK3CA expression and target-related microRNA expression in gastric cancer, miR-200b represses esophageal squamous carcinoma cell invasion in vivo without altering the expression of E-cadherin., Data show that myosin II supports a stable Rho zone at the at E-cadherin junctions., Prophylactic laparoscopic total gastrectomy with jejunal pouch reconstruction in patients with CDH1 germline mutation is feasible with 82% of patients having intramucosal diffuse gastric signet ring cell carcinoma in the resection specimen., expression of E-cadherin, and p120 negatively correlated with the tumor differentiation of oral squamous cell carcinoma., Demonstrate that HBx-HCCR-E-cadherin regulation pathway might play an important role in HBV-induced hepatocarcinogenesis., The CDH1 +54C/T was associated with susceptibility to endometriosis in Iranian population, and +54T allele may have a protective role in progression of endometriosis., Upregulation of E12/E47 by HBx ultimately and concomitant repression of E-cadherin expression led to epithelial-mesenchymal transition in human hepatocytes., CUGBP1 and HuR negate each other's effects in regulating E-cadherin translation by altering the recruitment of E-cadherin mRNA to PBs and play important roles in the regulation of intestinal barrier integrity., These data suggest that targeting the IL-8/AKT1 signaling pathway and DNMT1 may provide a potential therapeutic approach for blocking NPC metastasis., UHRF1 promotes osteosarcoma cell invasion by downregulating the expression of Ecadherin and increasing epithelialtomesenchymal transition in an Rb1dependent manner., PTTG2 induces psoriasis by regulating epidermal expression of vimentin and E-cadherin., H3K36me3 correlates with increased skipping of the final 83 base pairs of CDH1 exon 8 in gastric cancer cell lines, MTA1 plays an important role in Epithelial-to-mesenchymal transition (EMT) to promote metastasis via suppressing E-cadherin expression, resulting in a poor prognosis in MPM. MTA1 is a novel biomarker and indicative of a poor prognosis in MPM patients, downregulation of PDLIM1 in colorectal cancer samples correlated with reduced E-cadherin and membrane beta-catenin levels, These data suggest that the number of polyploid giant cancer cells and the EMT-related proteins E-cadherin, N-cadherin, and vimentin may be valuable biomarkers to assess metastasis in patients with breast cancer., The role of soluble E-cad in tumorigenesis and tumor progression and its significance in clinical therapeutics. [review], LOC389641 promotes pancreatic ductal adenocarcinoma progression and increases cell invasion by regulating E-cadherin with the possible involvement of TNFRSF10A., CDH1 expression is lost in 52% of colorectal carcinomas in this cohort., High E-cadherin concentration in presence of enhanced gamma-secretase activity is incontestably a paradoxically result, highlighting that E-cadherin loss is not a pre-requisite for Epithelial-Mesenchymal Transition., Calpain-mediated E-Cadherin fragmentation appears to promote intraperitoneal epithelial ovarian cancer progression., Evaluation of FoxC2 expression, alone or in combination with E-cadherin expression, may help to stratify non-small cell lung cancer patients for risk of disease progression, pointing to this EMT regulator as a potential prognostic marker, As a consequence, Slug transcription is down-regulated relieving A549 cells from Slug-mediated repression of E-cadherin transcription, thereby diminishing the metastatic potential of these oncogenic Ras-expressing NSCLC cells, These metastatic tumors revealed no detectable expression of CK8/18, E-cadherin, VCAM-1, and ICAM-1, Collectively, using tetraspanin CD9 in tandem with E-cadherin as a biomarker in renal cell carcinoma will help to not only distinguish between types, but also predict the metastatic potential of RCC., EZH2 mediates the regulation of E-cadherin expression by S100A4 and controls the proliferation and migration of gastric cancer cells., Truncating somatic alterations in the CDH1 gene occur in 84% of plasmacytoid carcinomas and are specific to this histologic variant., Data show that grape seed proanthocyanidins could inhibit cell proliferation, invasion and migration of A549 cells, which might be related to the down-regulation of epidermal growth factor receptor and N-cadherin and the up-regulation of E-cadherin., Data suggest that microRNA miR-101 may inhibit MDA-MB-231 breast cancer cell proliferation and migration by repressing DNA methyltransferase 3a (DNMT3a) expression and up-regulating E-cadherin expression., TWIST2 regulates epithelial-mesenchymal transition by depriving the epithelial cell phenotype of E-cadherin and endowing the mesenchymal cell phenotype with Vimentin, which may be involved in the progression and prognosis of ovarian cancer., Progressive loss of e-cadherin/alpha-catenin expression is associated with an aggressive phenotype (low differentiation, increased metastatic activity/advanced stage) in thyroid carcinomas., cell adhesion, Human RB and c-Myc activate expression of the murine E-cadherin gene in epithelial cells through interaction with transcription factor AP-2,
OFFICIAL_GENE_SYMBOL CDH1,
OMIM_DISEASE Breast cancer, lobular, Gastric cancer, familial diffuse, with or without cleft lip and/or palate, Ovarian carcinoma, somatic, Prostate cancer, susceptibility to, Endometrial carcinoma, somatic,
SP_COMMENT disease:Defects in CDH1 are a cause of gastric cancer [MIM:137215]; also known as hereditary familial diffuse gastric cancer (HDGC)., disease:Defects in CDH1 are a cause of susceptibility to endometrial cancer [MIM:608089]., disease:Defects in CDH1 are associated with ovarian cancer [MIM:167000]. Ovarian cancer is the leading cause of death from gynecologic malignancy. It is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity and the rare incidence of visceral metastases. These typical features relate to the biology of the disease, which is a principal determinant of outcome., disease:Defects in CDH1 are involved in dysfunction of the cell-cell adhesion system, triggering cancer invasion (gastric, breast, ovary, endometrium and thyroid) and metastasis., function:Cadherins are calcium dependent cell adhesion proteins., function:Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7., function:E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production., online information:E-cadherin entry, PTM:During apoptosis or with calcium influx, cleaved by a membrane-bound metalloproteinase (ADAM10), PS1/gamma-secretase and caspase-3 to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. Processing by the metalloproteinase, induced by calcium influx, causes disruption of cell-cell adhesion and the subsequent release of beta-catenin into the cytoplasm. The residual membrane-tethered cleavage product is rapidly degraded via an intracellular proteolytic pathway. Cleavage by caspase-3 releases the cytoplasmic tail resulting in disintegration of the actin microfilament system. The gamma-secretase-mediated cleavage promotes disaaaembly of adherens junctions., similarity:Contains 5 cadherin domains., subcellular location:Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm., subunit:Homodimer; disulfide-linked. Interacts directly, via the cytoplasmic domain, with CTNNB1 or JUP to form the PSEN1/cadherin/catenin adhesion complex which connects to the actin skeleton through the actin binding of alpha-catenin. Interaction with PSEN1, cleaves CDH1 resulting in the disassociation of cadherin-based adherens junctions (CAJs). Interacts with AJAP1, CTNND1 and DLGAP5., tissue specificity:Non-neural epithelial tissues.,