Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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cell division cycle 42(CDC42) cell division cycle 42(CDC42) Related Genes Homo sapiens
CHROMOSOME 1, 7,
CYTOBAND 1p36.1, 7p11.2,
ENSEMBL_GENE_ID ENSG00000070831,
GENERIF_SUMMARY Our findings indicate that different signaling cascades resulting in the activation of ..or Cdc42 can modulate the exocytotic process of neuroendocrine cells., Cdc42 is required for capillary lumen formation by vascular endothelial cells in three-dimensional extracellular matrices, Data show that TGF-beta-induced rearrangements of the actin filament system required the activity of the Rho GTPases Cdc42 and RhoA, because ectopic expression of dominant negative mutant Cdc42 and RhoA abrogated the response., signaling to the cytoskeleton involves IQGAP1 as a component, role for small GTPase CDC42Hs in the generation of skeletal muscle tumors., Structural basis for the selective activation of Rho GTPases by Dbl exchange factors, SopE binds to and locks the switch I and switch II regions of human Cdc42(1-178) in a conformation that promotes guanine nucleotide release., Cdc42 play essential role in regulating the formation of dendritic processes by dendritic cell, Effect of Mg(2+) on the kinetics of guanine nucleotide binding and hydrolysis, The ability of a Cdc42(D118N) mutant to survive under apoptotic conditions accounts for its superior transforming activity compared to other activated versions of Cdc42., Rac1 and Cdc42 are activated independent of RhoG, Cdc42 is involved in the mediation of intracellular lipid transport., Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading., Rac/Cdc42-dependent activation of MAPK/ERK is a critical event in the immediate phagocytic response of PMNs to microbial challenge., Data show that inhibition of endogenous RhoA, Rac1, and Cdc42 by their respective dominant negative mutants inhibits neurotensin-induced interleukin-8 protein production and promoter activity., VE-cadherin can serve as a scaffold involved in Cdc42 activation at the endothelial plasma membrane., TRE17 coprecipitated specifically with the active forms of Cdc42 and Rac1 in vivo. TRE17 is part of a novel effector complex for Cdc42 and Rac1, potentially contributing to their effects on actin remodeling., Upregulation during arachidonic acid mediated HeLa cell adhesion., Instead of inducing neurite formation, a constitutively active form of human Cdc42 stimulates the proliferation of rat PC12 cells in the presence of nerve growth factor., Cdc42 regulates the activitity of p21-activated protein kinase 5, Activated Cdc42 at the leading edge of a neutrophil in culture helps orient the cell's axis in a signaling complex with G beta gamma, PAK1, and PIXalpha., Activated CDC42 helps orient the neutrophil's axis in a signaling complex with Gbeta gamma, PAK1, and PIXalpha., Directional sensing requires GNB1-mediated PAK1 and PIX alpha-dependent activation of Cdc42., BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis., Activation of the small Rho GTPase Cdc42 plays a specific role in the actin reorganization mediated by CD28 in human T cells., direct activation of Cdc42 and Rac1 by invasive Salmonella is a prerequisite of Salmonella-mediated death of U937 cells., in neutrophils, Rac2 and Cdc42 are involved in FcR- and CR3-induced activation and for properly functioning signal transduction involved in the generation of oxygen radicals., The reorganization of actins into podosomes is controlled by CDC42 GTP-binding protein., Cdc42 signaling has a role in apoA-I-induced cholesterol efflux, The delayed activation of Cdc42 represents a negative-feedback mechanism that signals adherens junction reassembly after the increase in endothelial permeability induced by inflammatory mediators such as thrombin., Cdc42 synergistically with Rac1 induces lamellipodia and membrane ruffles in EGF-stimulated cells., Cdc42 signal transduction to the nucleus requires ACK-1 and ACK-2, Cdc42 has a role in mediation of UV-induced p38 activation by G protein betagamma subunits, novel role for Smad7 in TGF-beta-dependent activation of Cdc42, C. parvum invasion of target epithelia results from the organism's ability to activate a host cell Cdc42 GTPase signaling pathway to induce host cell actin remodeling at the attachment site., a specific region in Cdc42 confers the binding specificity to activated Cdc42-associated kinase, cross-talk between Rac and Cdc42 GTPases regulates generation of reactive oxygen species, role of frabin, a guanine nucleotide exchange factor specific for Cdc42, in the activation of Cdc42 during Cryptosporidium parvum infection of biliary epithelial cells, cdc42 has a role in activating c-Jun N-terminal kinase activation with Nck1, Both Cdc42 & Rac1 control the transport of essential immunostimulatory molecules to the DC surface. Cdc42 and Rac1 signaling controls DC morphology and conditions DCs for efficient CD8(+) T cell stimulation., Detailed analysis of backbone dynamics of the single-point mutant of Cdc42Hs(F28L) indicates how the mutation disrupts interactions that destabilize the local structure, leading to multiple time-scale motions of residues in the binding site., nucleotide-free Cdc42 might be sequestered by IQGAP1 to prevent signaling, localized activation in the trans-Golgi apparatus, microtubule-dependent Cdc42 activation at the cell periphery, and activation kinetics precisely coordinated with cell extension and retraction was revealed by a biosensor, Defined phospholipid oxidation products are capable of increasing EC barrier function via signaling mechanisms mediated by small GTPases Rac and Cdc42 leading to EC cytoskeletal remodeling and barrier restoration., actin has opposing roles in Cdc42p polarization, BNIP-2 in vivo induces cell dynamics by recruiting Cdc42, Distinct spatial association patterns between Cdc42 and its key effector proteins PAK1 and N-WASP controlling cytoskeletal remodeling were revealed., a Cdc42-MRCK signal mediates myosin-dependent cell motility and there is convergence between Rho and Cdc42 signalling, MMP-1 expression is maintained at a low level by Cdc42 via a repression of the Rac1 and ERK1/2 pathways when cell/extracellular-matrix interactions via integrins induce cytoskeleton organization, The cdc42 GTP-Binding Protein regulates the intracellular localization of PTEN in leukocytes and human transfected embryonic kidney cells., The cdc42 GTP-Binding Protein function was shown to be required for PTEN localization in leukocytes., Results describe a quantitative model of allosteric regulation of the Wiskott-Aldrich syndrome protein (WASP) by the Rho GTPase Cdc42., Silencing of Cdc42 by small interfering RNA induced massive apoptosis, indicating that tumor cell survival requires a minimal Cdc42 activity., Activation of small RhoGTPases is a key step in the mechanism of epithelial mesemchymal transdifferentiation and likely to be a contributor to tubulointerstitial fibrosis., a Cdc42 mutant is specifically activated by intersectin, binding of Cdc42 localizes Pak2 to the endoplasmic reticulum, where autophosphorylation alters association of the two proteins, the signals induced by integrin alpha6beta1 modulate at the level of PI3K and Cdc42 activity to allow platelets to actively form filopodia, The two unique glutamates in Cdc42 and basic region of WASp generate favorable electrostatic steering forces that control the accelerated WASp-Cdc42 association reaction., Cdc42 induces activation loop phosphorylation and membrane targeting of mixed lineage kinase 3, Cdc42 regulates AJ permeability by controlling the binding of alpha-catenin with beta-catenin and the consequent interaction of the VE-cadherin/catenin complex with the actin cytoskeleton., Results suggest that ABCA1 transduces signals from apolipoprotein A-I (apoA-I) by complexing and activating Cdc42 and downstream kinases and, therefore, acts as a full apoA-I receptor., Cdc42 is a critical regulator of T cell actin dynamics, T cell receptor clustering, and cell cycle entry. Cdc42 activity in specific locations at specific times is most critical for its function in T cell activation., PIP3 and Cdc42 maintain stable polarity with a single front and a single back not only by strengthening pseudopods but also, at longer range, by promoting RhoA-dependent actomyosin contraction at the trailing edge., NFAT1, a transcription factor connected with breast cancer metastasis, is activated by Wnt-5a through a Ca2+ signaling pathway in human breast epithelial cells which was simultaneously counteracted by a Wnt-5a-induced Yes/Cdc42 signaling pathway., Cdc42 is an important downstream factor in the pathway through which PKC mediates morphological and cytoskeletal effects, Cdc42 exerts its effects on cell migration in part through its effector Ack1, which regulates p130(Cas) signaling., Rho family GTPases play a distinct role in Salmonella-induced cellular responses., These results support a model whereby the synergic bundling activity of the IRSp53-Eps8 complex, regulated by Cdc42, contributes to the generation of actin bundles, thus promoting filopodial protrusions., Complex interplay of Rho, Rac and Cdc42 in the process of EphB-mediated cell retraction-recovery responses., Maspin controls mammary tumor cell migration through inhibiting Rac1 and Cdc42, but not RhoA GTPase., We propose that increased water influx through AQP9 is critically involved in the formation of membrane protrusions, and that AQP9-induced actin polymerization is augmented by activation of Cdc42 and PKC(zeta)., Signaling to the actin cytoskeleton by low and high concentrations of resveratrol may be differentially regulated by Rac and Cdc42., OxPAPC promoted novel interactions between focal adhesion and adherens junction complexes via paxillin and beta-catenin association, which was critically dependent on Rac and Cdc42 activities., Efficient phagosomal maturation and the subsequent eradication of ingested microbes in human neutrophils is dependent on a strictly regulated Cdc42 pathway., Results of this study suggest that the Rho-family GTPases are required for efficient invasion of HeLa cells by GBS., C. jejuni invade host target cells by a unique mechanism and the activation of the Rho GTPase members Rac1 and Cdc42 plays a crucial role in this entry process., These data suggest a mechanism whereby precise spatial guanine nucleotide exchange of Cdc42 by Dbl is dependent on functional ERM proteins and is important for directional cell migration., Results describe the neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, and show that it regulates neurite extension through SHP2 and Cdc42., IQGAP1 regulates Salmonella invasion through interactions with actin, Rac1, and Cdc42, FGFR-mediated phosphorylation of ephexin1 enhances the guanine nucleotide exchange activity toward RhoA without affecting the activity to Rac1 or Cdc42., Cdc42 signaling contributes to immune escape of cancer, These results indicate that START-GAP3/DLC3 has characteristics similar to other START-GAPs and the START-GAP family seems to share common characteristics., signaling pathway by which G(i)-coupled receptor specifically induces Rac and Cdc42 activation through direct interaction of Gbetagamma with FLJ00018., DOCK2 and DOCK9 specifically recognize Rac2 and Cdc42 through their switch 1 as well as beta2-beta3 regions and the mode of recognition via switch 1 appears to be conserved among diverse Rac-specific DHR-2 GEFs, Theses results support a novel role for FPR stimulation in enhancing intestinal epithelial cell restitution through PI3K-dependent activation of Rac1 and Cdc42., Silencing Cdc42 blocks activation of EGFR and Src induced by Ca2+ depletion, resulting in a reduction in E-cadherin degradation, role of RHO GTPases RAC1 and CDC42 in PGE(2)-mediated migratory responses of extravillous trophoblast cells, Bioinformatics and functional analyses revealed a spatially compartmentalized Rac/Cdc42 signaling network that operates in conjunction with multiple guanine-nucleotide exchange factors and GTPase-activating proteins to control neurite formation, LKB1 interacts only with active form of cdc42 and PAK, but not with inactive cdc42. Taken together, these results show that LKB1 is a critical mediator of the NSCLC polarity program in lung cancer cells through a novel LKB1-cdc42-PAK pathway., TGFbeta1 stimulates CCN2 expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism, Data show that Cdc42- and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling., analysis of TGF-beta1-independent changes in protein neosynthesis, p38alphaMAPK, and cdc42 in hydrogen peroxide-induced senescence-like morphogenesis, The purpose of this study was to characterize the significance of Rho processes in the cellular cytoskeleton., structural analysis of the influence of effector proteins on the signaling-active state of the small GTPase Cdc42, These findings suggest a novel MUC1-Src-CrkL-Rac1/Cdc42 signaling cascade following ICAM-1 ligation, through which MUC1 regulates cytoskeletal reorganization and directed cell motility during cell migration., Data suggests that actin polymerization and cdc42 are required for activation of integrin alpha2beta1, but not alpha(IIb)beta3, thereby critically regulating platelet adhesion to and activation by collagen., components of small GTPase signal transduction pathways may be directly targeted by alpha-synuclein oligomers which potentially leads to signaling deficits and neurodegeneration., salmonella enterica SopB colocalizes with activated Cdc42 near the plasmalemma, but there was no evidence that SopB alone can alter Cdc42 activity, The exocyst subunits Sec3 and Sec8 interact with the polarity protein IQGAP1 and that this interaction is triggered by active Cdc42 and RhoA, which are essential for matrix degradation., strongly activated in HTLV-1 infected T cell lines derived from HAM/TSP patients., Fanconi anemia group A proteins influence BM progenitor homing and adhesion via the small GTPase Cdc42-regulated signaling pathway., Cdc42 was found to be overexpressed with high incidence (60%) in colorectal cancer samples, and this expression was associated with silencing of ID4 with statistical significance (p<0.05)., 1) PAK plays a required role in hyperosmotic signaling through the PI3K/pTEN/Cdc42/PP2Calpha/p38 pathway, and 2) PAK and PP2Calpha modulate the effects of this pathway on focal adhesion dynamics., IpaC could not be shown to interact directly with Cdc42, a host GTPase closely tied to Shigella invasion., Nm23-H1 can negatively regulate cell migration and tumor metastasis by modulating the activity of Cdc42 and possibly other Rho family members through interaction with Dbl-1, In melanoma, expression of activated Cdc42 induces a mesenchymal-amoeboid transition and increases cell invasion., levels of GTPase Cdc42 could be associated with slow growth of BCL2 overexpressing immortalized breast cell line, the interaction of the RAGE cytoplasmic domain with Dia-1 is required to transduce extracellular environmental cues evoked by binding of RAGE ligands to their cell surface receptor, resulting in Rac-1 and Cdc42 activation and cellular migration, EB1 is controlled by c-Myc, RhoA, and CDC42, which have all been linked to hepatocellular carcinoma (HCC) malignancy., Cdc42 was necessary for the growth and maintenance of already established lymphomas in vivo. These data open perspectives for new therapeutic strategies by revealing a mechanism of regulation of anaplastic large cell lymphoma cell growth through Cdc42, Cdc42 regulates epithelial tissue morphogenesis by controlling spindle orientation during cell division., study found Vibrio VopS could act to covalently modify a conserved threonine residue on Rho, Rac & Cdc42 with AMP; resulting AMPylation prevented interaction of Rho GTPases with downstream effectors, inhibiting actin assembly in the infected cell, Cdc42 has a novel role in controlling centrosome organization in unstimulated cells in addition to its known function as a regulator of centrosome reorientation in stimulated cells., Data demonstrate that spindle orientation in adherent cells is regulated by two distinct pathways downstream from Cdc42 and uncovers a novel role of the Cdc42-PAK2-betaPix-actin pathway for this mechanism., Cdc42 activity is impaired in beta1 integrin-deficient T cells that form conjugates with antigen-presenting cells but is partially restored in the context of an antigen-specific synapse., The higher exchange activity of ITSN1L towards the GDP-bound conformation of Cdc42 could represent an evolutionary adaptation of this GEF that ensures nucleotide exchange towards the formation of the signalling-active GTP-bound form of Cdc42., an unexpected TGF-beta signaling independent role for TbetaRIII in activating Cdc42, altering the actin cytoskeleton and reducing directional persistence to inhibit random migration of both cancer and normal epithelial cells, Data reveal a multicomponent kinase signaling pathway downstream of integrin-matrix interactions and Cdc42 activation involving PKCepsilon, Src, Yes, Pak2, Pak4, B-Raf, C-Raf and ERK1/2 to control EC lumen formation in 3D collagen matrices., A model where IQGAP1 serves as a phosphorylation-sensitive conformation switch to regulate the coupling of cell growth and division through a novel CDC42-mTOR pathway., T-cadherin transcriptionally activated Rac1 and Cdc42., Results show that this unique and specific bacterial entry process is dependent on the cooperation and activation of Rho family GTPase Cdc42, PI3K, and Akt., CSF-1-induced WASP activation was fully Cdc42-dependent., Results suggest that adiponectin promotes the migration activities of endothelial progenitor cells mainly through PI3-kinase/Cdc42/Rac1., ITSN-2L, a guanine nucleotide exchange factor for Cdc42, regulates different steps of caveola endocytosis in ECs by controlling the temporal and spatial actin polymerization and remodeling sub-adjacent to the plasma membrane., In summary, these results suggest that actin, likely modulated by the GTPases RhoA and Cdc42 and by bacterial proteins, is involved in the formation of the typical parasitophorous vacuole., Rac1 and Cdc42 signaling has a role during early herpes simplex virus type 1 infection of keratinocytes, Recycling endosome trafficking to the Golgi complex through a pathway involving Src-family kinases, Cdc42, and Rab11a plays a general role in death signaling by mediating regulated changes in Golgi dynamics., Cdc42-GDP can inhibit TC21 activation by RasGRF GEFs, demonstrating that Cdc42 negatively affects the functions of RasGRF GEFs irrespective of the GTPase being targeted., phosphorylation of Cdc42 at Ser-71, exemplarily induced by epidermal growth factor, reduces Clostridium difficile toxin A-induced changes in the intestinal barrier function., Internalization of DENV-2 into endothelial cells requires viral induction of dynamic filopodia regulated by Rac1 and Cdc42 cross-talk and myosin II motor activities., Activation of Cdc42 GTPase through p210(Bcr-Abl) tyrosine kinase signaling in CML cells contributes to defects in SDF-1alpha-chemotactic response due to desensitization of the actin polarization signal required for directional migration., HS could regulate fusion via fine tuning of RhoA and Cdc42 activities., Cdc42 regulates the uropod through CD11b signaling to maintain polarity in migrating neutrophils., Cell division cycle 42 (CDC42) showed a difference between follicular cells from follicles leading to a pregnancy or developmental failure., These results suggest that the novel gene, Kenae/CCDC125, acts as a regulator of cell motility through RhoA, Rac1 and cdc42., Data identify a novel signaling pathway in the endocrine L cell, whereby Cdc42 regulates actin remodeling, activation of the cannonical 1/2-ERK1/2 pathway and PAK1, and GLP-1 secretion in response to insulin., RhoA plays an antagonistic role to Rac1/Cdc42 in the control of mammary epithelial acinar morphogenesis., this work does not conform to current views that the inverse-BAR domain or Cdc42 controls IRSp53 localization but provides an alternative model of how IRSp53 is recruited (and released) to carry out its functions at lamellipodia and filopodia., MT1-MMP and Cdc42 co-regulate tumor cell invasion in 3D collagen matrices., expression of several highly significant cancer related genes require the activities of Rac1 and/or Cdc42 which may also play a critical role in cellular transformation, Impaired NK-cell migration in WAS/XLT patients, Endothelial lumen signaling complexes control 3D matrix-specific tubulogenesis through interdependent Cdc42- and MT1-MMP-mediated events., TSC2 has a role in controlling cell polarity and migration by regulating CDC42 and RAC1 activation, These results suggest that plasma membrane sphingomyelin is required for targeting of Helicobacter pylori VacA to membrane rafts important for subsequent Cdc42-dependent pinocytic cellular entry., This study demonstrates that controlled regulation of PAK4 is required for apical junction formation in lung epithelial cells and highlights potential cross-talk between two Cdc42 targets, PAK4 and Par6B., Cdc42 may influence endocytic membrane trafficking by regulating the formation and activity of the Toca-1/N-WASP complex., Cdc42, by inhibiting GSK-3beta, markedly improves the angio-architecture and lumenization of neovessels induced by VEGF., Activation of Rac1 and Cdc42 correlated with stabilized barrier functions in intestinal epithelium., Expression of constitutively active Cdc42 decreasea RhoA-GTP level in human lung microvascular lymphatic endothelial cells., Important role played by Cdc42 in CCL19-induced migration and invasion of squamous cell carcinoma of the head and neck cells., Cdc42 was found to be necessary for breast cancer cell invasion but dispensable for cell migration, Data show that miR-185 is a negative regulator of RhoA and Cdc42 and their cellular activities, and could inhibit proliferation and invasion of colorectal cancer cells., miR-137 is frequently down-regulated in gastric cancer and is a negative regulator of Cdc42., Cdc42-dependent formation of the ZO-1/MRCKbeta complex at the leading edge controls cell migration., Naa10p binds to the GIT-binding domain of PIX, thereby preventing the formation of the GIT-PIX-Paxillin complex, resulting in reduced intrinsic Cdc42/Rac1 activity and decreased cell migration, Cdc42 were down-regulated on the protein level.The formation of filopodia, which requires Cdc42, was inhibited in miR-206 transfected cells, even under EGF stimulation, The Cdc42-APC interaction induces localization of both APC and mutant APC and may thus play a direct role in the functions of these proteins., These results demonstrate an important role for FGD1/Cdc42 signaling in human mesenchymal stem cells osteogenesis., Interaction of the Salmonella Typhimurium SopB with host Cdc42 is involved in intracellular replication., HIV-1 activates Cdc42 and induces membrane extensions in immature dendritic cells to facilitate cell-to-cell virus propagation., Aberrant expression of Annexin A2 and Cdc42 play a role in carcinogenesis, differentiation and metastasis of esophageal squamous cell carcinomas., Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors., endogenous Cdc42 could exert a negative regulatory influence on intrinsic migration/invasion and some potentially relevant changes in phosphorylation of PKCdelta, Erk1/2, and PKA of some aggressive breast cancer cells, Mutation of threonine(35) leads to loss of conformational freedom in the Cdc42 Switch I signaling pathway that could affect effector-regulatory protein interactions., Demonstrate a role for RasGRF1/2 as negative regulators of Cdc42 activation, suppressing tumor cell movement, cytoskeletal dynamics and cell transformation., Cdc42 enhances the resistance of colon cancer cells to several antitumor drugs., Phosphatase and tensin homologue deleted on chromosome 10 may influence apoptosis in colorectal epithelium through Cdc42 signalling, thus providing a regulatory framework for both polarised growth and programmed cell death., Burkholderia cenocepacia perturbs actin architecture by inactivating Rho family GTPases, particularly Rac1 and Cdc42., CDC42 may have a key role in ameloblastoma neoplastic epithelial cell phenotype determination, as well as in variant and subtype determination., Estrogen enhances the drug resistance in breast cancer cells, possibly by enhancing Cdc42 expression., The guanine nucleotide exchange factors RhoGEF6 and RhoGEF7 were necessary for Cdc42 activation within the NK cell immunological synapse., delta-catenin facilitated invasion of lung cancer cells by upregulating the mRNA and protein levels of cdc42, Data suggest a potential therapeutic role for curcumin in inducing Cdc42-mediated inhibition of invasion of lung cancer cells., silencing Cdc42 reduced influenza A virus replication, whereas silencing ARHGAP21 increased the virus replication., Using synthetic derivatives of the enteropathogenic Escherichia coli guanine-nucleotide exchange factor (GEF) Map, authors discover that Cdc42 GTPase signal transduction is controlled by the interaction between Map and F-actin., analysis of the SopB GTPase binding domain in complex with Cdc42 shows for the first time that SopB structurally and functionally mimics a host guanine nucleotide dissociation inhibitor by slowing cdc24 nucleotide exchange., Data support the CDC42 gene as a candidate schizophrenia susceptibility gene., Modulation of Cdc42 signaling through FAK by receptor activation underlies changes in growth cone motility., study demonstrated that LMP1 acts through its transmembrane domains to preferentially induce Cdc42 activation in various types of epithelial cells, including NPC cells., FMNL2 is a novel elongation factor of actin filaments that constitutes the first Cdc42 effector promoting cell migration and actin polymerization at the tips of lamellipodia., several Rho family small GTPases activate PI3K by an indirect cooperative positive feedback that required a combination of Rac, CDC42, and RhoG small GTPase activities, studies implicate Cdc42 in Ras-driven tumor growth and suggest that targeting Cdc42 is beneficial in Ras-mediated malignancies, endothelin 1 stimulates trophoblast cell migration through GTP binding protein CDC42 activation, overexpression of Dsg3 results in a remarkable increase of Rac1 and Cdc42 activities, Cdc42 controls actin depletion at the immunological synapse., Epithelial junction formation and morphogenesis require a dual activity complex, containing SH3BP1 and CapZ, that is recruited to sites of active membrane remodeling to guide Cdc42 signaling and cytoskeletal dynamics., Arhgef15 acts as an endothelial cell-specific GEF to mediate VEGF-induced Cdc42 activation and potentiate RhoJ inactivation, thereby promoting actin polymerization and cell motility., Inhibition of S1P3 receptors prevented E2-induced activation of Cdc42, supporting the important role of the S1P receptor in E2 signaling., The transient Cdc42 depletion was sufficient to decrease experimental lung metastases, which suggests that its role in endothelial attachment is important for metastasis., Data suggest that microRNA 137 influences cell proliferation via regulation of expression of CDC42 and CDK6 (cyclin-dependent kinase 6); expression of microRNA 137 in lung cancer cells downregulates CDC42/CDK6 and induces G1 cell cycle arrest., Constitutively active Cdc42 or NFAT1 mutants fully restore the impaired expansion of SWAP-70-like adapter of T cells (Def6)-deficient CD8+ T cells., DOCK7 binds to the RAGE cytoplasmic domain and transduces a signal to Cdc42., Cdc42 interacts with the exocyst complex to promote phagocytosis., these results establish a role of miR-330 in negatively regulating Cdc42 expression and colorectal cancer cell proliferation., Prenylated and palmitoylated brain Cdc42 did not interact with RhoGDIalpha., The aim of this study was to examine the expression of ERM (ezrin, moesin) and Rho (RhoA, RhoB and Cdc42) proteins in breast cancer (BC) patients., Silencing of LRP1B altered the expression of focal adhesion complex-associated proteins, and Cdc42/RhoA activities., Cdc42 differentially modulate cigarette smoke-induced airway cell migration through p120-catenin-dependent and -independent pathways, Prom2 protrusions primarily localize to lipid rafts and recruit cholesterol into protrusions and away from caveolae, leading to increased phosphorylation of caveolin-1, which inhibits Cdc42-dependent endocytosis, Cdc42 knockdown were c-Cbl-dependent was provided by transducing Cdc42 knockdown cells with secondary c-Cbl shRNAs before transplantation., Negative pressure wound therapy activates Cdc42 pathway facilitating migration to accelerate wound healing., The transcription of cdc42, a kind of Rho GTPase which plays a key role in actin polymerization, was reduced by down-regulated B antigen expression., Data show that macrophages on gastric and colorectal cancer cells migration through epidermal growth factor receptor and phosphorylation of Akt, c-Src and ERK1/2, and led to an increase of RhoA and Cdc42 activity., Acute ischemic stroke was associated with reduced levels of Cdc42 protein in peripheral lymphocytes., The action of DOCK7 in vivo may involve the coordinated integration of Cdc42/Rac1 signaling in the context of the membrane recruitment of a DOCK7 guanine nucleotide exchange factor (GEF) complex., activated Rac1/Cdc42 is a vascular regulator of tumor angiogenesis and that it may reduce stability of the p53 protein to promote VEGF expression by enhancing p53 protein ubiquitin, These results indicate that Neisseria meningitidis selectively exploits the epithelial microenvironment in order to protect itself from LL-37 via a RhoA and Cdc42 mediated mechanism., Active Rho GTPase Cdc42 can greatly enhance colorectal cancer cell SW480 to spread, migrate, and invade, which may contribute to colorectal cancer metastasis., Study determined that p16-stimulated cell migration requires the Cdc42 GTPase., a significant role of S79 in PAK1 activation and a noval mechanism of the CRIB-mediated interaction of PAK1 with Cdc42 and Rac, Expression of Cdc42 (and Asef) together was associated with tubular injury with 100% specificity., Data indicate mTOR kinase-independent function and mechanism of Rictor in the regulation of neutrophil chemotaxis, and suggest that the small Rho GTPases Rac and Cdc42 serve as downstream effectors of Rictor to regulate actin assembly., Differential expression of miR-195 in esophageal squamous cell carcinoma and miR-195 expression inhibits tumor cell proliferation and invasion by targeting of Cdc42, Rs2349775 (NXPH1) and rs17837965 (CDC42) were associated with diarrhoea and constipation predominant irritable bowel syndrome, respectively, in two independent cohorts., findings demonstrate that dual lipidation of Cdc42-palm represents an important regulator of morphogenic signalling in hippocampal neurons., Cdc42 overexpression induces hyperbranching in the developing mammary gland by enhancing cell migration., a possible role of GPR97 in lymphatic remodeling, These results indicate that Wnt5b is involved in the migration ability of OSCC cells through active Cdc42 and RhoA., we show that cIAP1 regulates TNF-induced actin cytoskeleton reorganization through a cdc42-dependentpathway, Our observations suggest that ITSN1 is an important general regulator of Cdc42-, Nck- and N-WASP-dependent actin polymerisation, Invasion of host cells, which occurs at a low frequency, does not seem linked to Rac1 activation by Vibrio parahaemolyticus VopC, but instead appears to require CDC42., Our data indicate that injured keratinocytes induce MMP-1 expression through ERK activation, and this process is negatively regulated by Cdc42 activity., Dbl3 drives Cdc42 signaling at the apical margin., A FRET-based Cdc42 biosensor was used to examine the effects of the rigidity of three-dimensional collagen matrices on spatiotemporal activity of Cdc42 in endothelial colony forming cells., Listeria monocytogenes emply a novel mechanism of bacterial spread involving pathogen-induced downregulation of host Cdc42., IRSp53 adopts a closed inactive conformation that opens synergistically with the binding of human Cdc42 to the CRIB-PR and effector proteins, such as the tumor-promoting factor Eps8, to the SH3 domain., YES kinase as a proximal glucose-specific signal in the Cdc42-signaling cascade., The human cdc42 gene is a direct target of miR-204., CCH-mediated inhibition of NHE3 activity is not dependent on clathrin and involves lipid rafts and requires Cdc42., Increased miR-224 diminished Cdc42 and SMAD4 expressions at both the protein and mRNA levels and inhibited the formation of actin filaments., CDC42 is activated by phosphatidylinositol 5-phosphate, regulating actin dynamics and cell invasion., These findings show that overexpression of PODXL enhanced invadopodia formation and tumor metastasis by inducing Rac1/Cdc42/cortactin signaling network., Findings suggest that Wnt5a enhances cell migration through activation of Cdc42 and inactivation of RhoA in human corneal endothelial cells., inhibiting Cdc42 function impairs vessel co-option and converts pericytes to a phagocytic/macrophage-like phenotype, thus favoring an innate immune response against the tumor., CDC42 has a crucial role in senescence-associated inflammation and atherosclerosis., Findings indicate that tricellular contacts play crucial roles in regulating the actomyosin-mediated apical junctional complex tension through the tricellulin-Tuba-Cdc42 system., Cdc42Hs binds to the effector domain of PAK3, Cdc42 may promote breast cancer cell migration and invasion by inhibiting ERK5 phosphorylation and ERK5 expression may be inversely correlated with the progression of some breast tumors., Snail regulates the motility and invasiveness of oral cancer cells via RhoA/Cdc42/p-ERM pathway., Silencing of CDC42 decreased expression of N-myc in BE(2)-C and BE(2)-M17 cells., Cdc42 and the formins diaphanous and DAAM play pivotal roles in heart lumen formation through the spatiotemporal regulation of the actomyosin network., metformin impairs Rho GTPases signaling to induce apoptosis via JNK pathway, The homeostatic function of miR-18a within the miR-17-92 cluster in colorectal cancer cells may be achieved through suppression of CDC42 and the PI3K pathway., Cdc42 overexpression significantly improved the ability of cervical cancer cells to migrate possibly due to improved pseudopodia formation., Suggest that the combined aberrant expression of miR-195 and Cdc42 mRNA can serve as a promising unfavorable prognostic biomarker in esophageal squamous cell carcinoma., Cdc42 and its specific guanine nucleotide-exchange factor (GEF), Tuba, localize to linear invadosomes, and both are required for linear invadosome formation, MiR-25, by targeting CDC42, is an important regulator in NSCLC., Results provide novel evidence that low expression of SLIT2 correlates with poor prognosis and promotes metastasis in ESCC, which may be regulated by the Cdc42-mediated pathways., HIV-1 Tat inhibits phagocytosis by preventing the recruitment of Cdc42 to the phagocytic cup., PAK4 phosphorylates Par6B at Ser143 blocking its interaction with Cdc42., Cdc42 is implicated in the CFTR biosynthesis and processing, maintaining the level of Cdc42 and its effectors in cells, tumor progression can be controlled., Study shows that activation of CDC42 in HeLa cells causes increased radiosensitivity, cells arrest in G2/M and reduced survival. These results complete the understanding of the signaling roles of CDC42 in maintaining genomic stability and integrity., COPI tubular transport complements cisternal maturation in explaining how anterograde Golgi transport is achieved, and that bidirectional COPI transport is modulated by environmental cues through CDC42., This study showed that cdc42 messenger RNA levels were significantly downregulated specifically in deep layer 3 pyramidal cells in patient with schizophrenia., In marked contrast to invadopodia, this degradation does not require the action of Src kinase, Cdc42 or Dyn2. Rather, inhibition of Dyn2 causes a marked upregulation of stromal matrix degradation, Rich1 negatively regulates the epithelial cell cycle, proliferation and adhesion by CDC42/RAC1-PAK1-Erk1/2 pathway., Robo1 promoted cell division cycle 42 (Cdc42) expression in HUVECs, and a distorted actin cytoskeleton in HUVECs was observed when Robo1 expression was suppressed. In conclusion, Robo1 promoted angiogenesis in HCC mediated by Cdc42., IQGAP1 and its two isoforms regulate the actin-cytoskeleton alone and with their binding partners, Rac and Cdc42, thereby controlling diverse cellular processes, such as cell migration and adhesion. (Review), The structural details of the cdc42 protein have been described that determine its recognition by the bacterial c3 exoenzyme., PAK4 binding to cell-cell junctions is dependent on Cdc42., Ketorolac has a novel pharmacologic activity conferred by the R-enantiomer and R-ketorolac achieves sufficient levels in the peritoneal cavity to inhibit Rac1 and Cdc42, contributing to the observed survival benefit in women who received ketorolac, FMNL3 interacts with Cdc42 and RhoJ, two Rho family GTPases known to be required for lumen formation. FMNL3 and RhoJ are concentrated at the early apical surface, or AMIS, and regulate the formation of radiating actin cables from this site., Results suggest that the role of polypyrimidine tract binding protein 1 (PTBP1) in tumorigenesis may be partly mediated by its regulation of cdc42 GTP-binding protein (CDC42) alternative splicing and CDC42-v2 might function as a tumor suppressor., CDC42 independently regulated the antitumor effects of miR-137 in human hepatocellular carcinoma., Authors conclude that a transient interaction between Cdc42 and GRAF1 drives endocytic turnover and controls the transition essential for endosomal maturation of plasma membrane internalised by this mechanism., MARCKS upregulation increases vascular smooth muscle cell motility by activation of Rac1 and Cdc42, promoting neointima formation., Results show that the activation of cdc42 GTP-binding protein (Cdc42) is a process of conformational changes., CDC42 is a key regulator involved in regulating the proliferation, migration and invasion of gastric cancer., Data indicate enantiomer selective interaction of R-naproxen and R-ketorolac with Rho family GTPases Rac1 and Cdc42., we discovered distinct predictive performance of Rac1 and Cdc42 depending on the migration modes, indicating that Rac1 and Cdc42 contribute to persistent and random migration, respectively, Chemotactic steering and de novo polarization are both directed by locally excitable Cdc42 signals in neutrophils., Data suggest LPA (lysophosphatidic acid; acting via LPAR1) and endothelin activate Cdc42, concurrent with biphasic decrease in Rac1 activity, differential effects on RhoA; LPA/endothelin stim. leads to remodeling of invadosomes in melanoma cells., Shp2 also mediates Cdc42 repression, and HDAC6 inhibition or co-suppression of ERK/myosin II promotes normal epithelial lumen phenotype without increasing Cdc42 activity., Loss of FAT1 results in decreased cell adhesion and migration in fibroblasts and podocytes and the decreased migration is partially reversed by a RAC1/CDC42 activator., miR-1 bound both MALAT1 and cdc42 3'UTR directly. Further study showed that MALAT1 induced migration and invasion of breast cancer cells while reduced the level of cdc42.,
OFFICIAL_GENE_SYMBOL CDC42,
OMIM_DISEASE Takenouchi-Kosaki syndrome,
SP_COMMENT enzyme regulation:Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase., function:Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Causes the formation of thin, actin-rich surface projections called filopodia., similarity:Belongs to the small GTPase superfamily. Rho family., similarity:Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily., subunit:The GTP-bound form interacts with CCPG1 (By similarity). Interacts with CDC42EP1, CDC42EP2, CDC42EP3, CDC42EP4, CDC42EP5, CDC42SE1, CDC42SE2, PARD6A, PARD6B and PARD6G (in a GTP-dependent manner). Interacts with activated CSPG4 and with BAIAP2. Interacts with Zizimin1/DOCK9 and Zizimin2/DOCK11, which activate it by exchanging GDP for GTP. Interacts with NET1 and TCGAP/SNX26. Part of a complex with PARD3, PARD6A or PARD6B and PRKCI or PRKCZ.,