Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
The Database for Annotation, Visualization and Integrated Discovery
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DAVID Functional Annotation Table
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FERM, ARH/RhoGEF and pleckstrin domain protein 2(FARP2) FERM, ARH/RhoGEF and pleckstrin domain protein 2(FARP2) Related Genes Homo sapiens
CHROMOSOME 2,
CYTOBAND 2q37.3,
ENSEMBL_GENE_ID ENSG00000006607,
GENERIF_SUMMARY FRG is a member of Cdc42-GEF and plays an important role in the signaling pathway downstream of G protein-coupled receptors,
OFFICIAL_GENE_SYMBOL FARP2,
SP_COMMENT function:Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton., similarity:Contains 1 DH (DBL-homology) domain., similarity:Contains 1 FERM domain., similarity:Contains 2 PH domains., subunit:Interacts with PLXNA1. Interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity. Dissociates from PLXNA1 when SEMA3A binds to the receptor. Interacts with PIP5K1C via its FERM domain. The interaction with PIP5K1C is enhanced by SEMA3A binding.,