Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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CD63 molecule(CD63) CD63 molecule(CD63) Related Genes Homo sapiens
CYTOBAND 12q12-q13,
GENERIF_SUMMARY Results show that AP-3 is absolutely required for the delivery of CD63 to lysosomes via the trans-Golgi network., C-kit is physically associated with transmembrane 4 superfamily proteins CD9, CD63, and CD81, that may negatively modulate c-kit and thus regulate c-kit receptor sensitivity to SLF in hematopoietic progenitors., downregulation of CD63 antigen is associated with breast tumor progression, possible role in HIV-1 infections specific for macrophages, Post-translational modification of CD63 may be involved in the functional and morphological changes of MHC class II compartments that occur during dendritic cell maturation, relationships between the expression levels of CD61, CD63, and PAC-1 on the platelet surface and the incidences of acute rejection and tubular necrosis as well as the recovery of graft function after renal transplantation, Upon platelet interaction with fibrinogen, cholesterol accumulated at the tips of filopodia and at the leading edge of spreading cells; cholesterol-rich raft aggregation was accompanied by concentration of c-Src and CD63 in these cell domains, The study on CD63 included its chemistry eg. if it had and O-linked carbohydrate that was digested with O-glycanase., CD63 serves as an adaptor protein that links its interaction partners to the endocytic machinery of the cell., results suggest that CD9, CD63, CD81, and CD82 could play a role in modulating the interactions between immature DCs and their environment, slowing their migratory ability. However, only CD63 would intervene in the internalization of complex antigens, Constitutive expression of CD63 may indicate that this factor does not play a direct role in thyroid carcinogenesis, CD63 represents an activation-induced reinforcing element, whose triggering promotes sustained and efficient T cell activation and expansion., The linkage of CD63 with PI 4-kinase may result in the recruitment of this signaling enzyme to specific membrane locations in the platelet where it influences phosphoinositide-dependent signaling and platelet spreading., This study identifies a trafficking pathway from CD63-positive multivesicular bodies to the bacterial inclusion, a novel interaction that provides essential lipids necessary for maintenance of a productive intracellular infection., CD63 is recruited to already-budded Weibel-Palade bodies by an AP-3-dependent route, CD63-syntenin-1 complex is abundant on the plasma membrane, CD63 is a cell surface binding partner for TIMP-1, regulating cell survival and polarization via TIMP-1 modulation of tetraspanin/integrin signaling complex., Chronic urticaria serum-induced CD63 expression assay performed on atopic whole blood by means of tricolor flow cytometry could be the most useful tool for identification of a subset of patients with autoimmune chronic urticaria., In conclusion, using well-defined experimental conditions, the measurement of CD203c up-regulation on basophils in response to specific allergens is as reliable as CD63-BAT for the in vitro diagnosis of patients with IgE-mediated allergy., positive correlation between CD63 and erythrocyte sedimentation rate in rheumatoid arthritis, Results suggest that CD63 can be a biomarker for predicting the prognosis in early stages of lung adenocarcinoma., These results suggest that chronic obstructive pulmonary disease patients have different patterns of CD63 expression and polymorphonuclear neutrophils mediator release than healthy individuals., Data show that HIV-1 envelope glycoprotein (Env) and core protein (Gag) colocalize strongly with CD63 and CD81 and less strongly with CD9, and suggest that HIV-1 promotes virus assembly and cell-cell transfer by targeting these plasma membrane proteins., There is low expression of the proteins and mRNA of ME491/CD63 and integrin alpha5 in ovarian cancer. The lower the pathological differentiation is, the more significant the loss of expression is and the more likely metastasis is., PrP(c) at the cell surface of cultured human erythroblasts is rapidly internalized through the endosomal pathway, where it colocalizes with the tetraspanin CD63., Data show that an N-terminal deletion mutant of CD63 blocks entry of CXCR4-using, T-cell tropic human immunodeficiency virus type 1 (X4 HIV-1) by suppressing CXCR4 surface expression., CD63 plays a role in the regulation of ROMK channels through its association with RPTPalpha, which in turn interacts with and activates Src family PTK, thus reducing ROMK activity., Together, our results indicate that at least in tissue culture, CD63 expression is not required for either the production or the infectivity of HIV-1., These studies confirm CD63 as a constituent in multivesicular body-to-chlamydial inclusion transport but it is not required for this association., Induction of hypercortisolism in healthy volunteers was associated with a trend toward higher expression of glycoprotein 53 on the platelet surface., CD63 is involved in granule targeting of neutrophil elastase, Antigen-induced p38 MAPK phosphorylation in human basophils essentially contributes to CD63 upregulation, the activation-induced degranulation of Fas ligand has distinct requirements and involves different mechanisms than those of the granule markers CD63 and CD107a/Lamp-1, Exotest for CD63+ plasma exosomes had limited sensitivity but the Exotest for detection of caveolin-1+ plasma exosomes showed a higher sensitivity. Caveolin-1+ plasma exosomes were significantly increased with respect to CD63+ exosomes in patients group, CD9, CD81 and CD63 are negative regulators of HIV-1-induced cell-cell fusion., Serum sCD163 is a homogenous protein covering more than 94% of the CD163 ectodomain including the haptoglobin-hemoglobin -binding region., Surface expression of the novel CD63 variant is a distinguishing feature of mast cells, which are are stable, multiple-use cells capable of surviving and delivering several consecutive hits, CD63 expression results from only the anaphylactic degranulation form of histamine release., this work provides the first evidence of a TIMP-4/CD63 association in astrocytoma tumor cells, ameloblastin is expressed in osteoblasts and functions as a promoting factor for osteogenic differentiation via a novel pathway through the interaction between CD63 and integrin beta1, These findings suggest that CD63 plays an early post-entry role prior to or at the reverse transcription step., decreased levels of CD63 were associated with distant and lymph node metastasis status and does play a direct role in human gastric carcinogenesis., C-terminal modifications that retain LMP1 in Golgi compartments preclude assembly within CD63-enriched domains and/or exosomal discharge leading to NF-kappaB overstimulation., shRNA knockdown in B lymphoblastoid cell line results to increased CD4(+) T-cell recognition, Loss of CD63 has a similar phenotype to loss of P-selectin itself, thus CD63 is an essential cofactor to P-selectin., Timp1 is assembled in a supramolecular complex containing CD63 and beta1-integrins along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway., Collectively, these findings indicate that CD63 may support Env-mediated fusion as well as a late (post-integration) step in the HIV-1 replication cycle., CD9 and CD63 tetraspanins block HIV-1-induced cell-cell fusion at the transition from hemifusion to pore opening., Data suggest that TIMP1 (tissue inhibitor of metalloproteinase-1) acts as chemoattractant for neural stem cells (NSC); TIMP1 enhances NSC adhesion, migration, and cytoskeletal reorganization; these effects are dependent on CD63/CD29 (integrin beta1)., these results indicated that high glycosylation of CD63 by RPN2 is implicated in clinical outcomes in breast cancer patients, CD63 tetraspanin is a negative driver of epithelial-to-mesenchymal transition in human melanoma cells., TM4SF5 interacted with CD151, and caused the internalization of CD63 from the cell surface., Diesel exhaust exposure during exercise induces platelet activation as illustrated by a dose-response increase in the release of CD62P and CD63., Data show that CD63 is a crucial player in the regulation of the tumor cell-intrinsic metastatic potential by affecting cell plasticity., It was shown that treatment of macrophages with anti-CD63 inhibits CCR5-mediated virus infection in a cell type-specific manner, but that no inhibition of CXCR4-tropic viruses occurs., Our findings reveal that elevated levels of TIMP-1 impact on neutrophil homeostasis via signaling through CD63., These findings indicate that rhTIMP-1 promotes clonogenic expansion and survival in human progenitors via the activation of the CD63/PI3K/pAkt signaling pathway, CD163(+) TAMs in oral premalignant lesions coexpress CD163 and STAT1, suggesting that the TAMs in oral premalignant lesions possess an M1 phenotype in a Th1-dominated micromilieu.,
SP_COMMENT function:This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation., miscellaneous:Lack of expression of CD63 in platelets has been observed in a patient with Hermansky-Pudlak syndrome (HPS). Hermansky-Pudlak syndrome (HPS) is a genetically heterogeneous, rare, autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS., similarity:Belongs to the tetraspanin (TM4SF) family., subcellular location:Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules., tissue specificity:Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.,