Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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Rho guanine nucleotide exchange factor 1(ARHGEF1) Rho guanine nucleotide exchange factor 1(ARHGEF1) Related Genes Homo sapiens
CHROMOSOME 19,
CYTOBAND 19q13.13,
ENSEMBL_GENE_ID ENSG00000076928,
GENERIF_SUMMARY coexpression of a dominant negative PDZ-RhoGEF abrogated the ability of plexin-B1 to cause stress fiber formation, rgRGS domain may serve a structural or allosteric role in the regulation of the nucleotide exchange activity of p115RhoGEF on Rho by Galpha(13), CD44 interaction with p115RhoGEF and ROK plays a pivotal role in promoting Gab-1 phosphorylation leading to Gab-1.PI 3-kinase membrane localization, AKT signaling, and cytokine (M-CSF) production during HA-mediated breast cancer progression, data demonstrate a pathway of Rho activation involving protein kinase c alpha-dependent phosphorylation of p115Rho guanine exchange factor, Data show that different rho guanine nucleotide exchange factors (rhoGEFs; p115rhoGEF, LARG and PDZrhoGEF) mediate downstream rho signaling by the thrombin and lysophosphatidic acid receptors., Several features of a typical alpha/RGS interaction are preserved in the alpha(13)/p115RhoGEF interaction., analysis of a novel cross-talk exerted from the LPA/Galpha(13)/p115RhoGEF/RhoA pathway to the beta(2)-adrenergic receptor/Galpha(s)/adenylyl cyclase pathway, A pronounced and rapid translocation of p115-RhoGEF from the cytosol to the plasma membrane was observed upon activation of several G(12/13)-coupled receptors in a cell type-independent fashion., Data show that microtubules in neighboring cells reorient and target p115 RhoGEF to sites where dying cells are squeezed out of the epithelial sheet., ARHGEF1 is involed in hypertension by controlling its molecular mechanisms., The linker region connecting the N-terminal RGS-homology domain and the Dbl homology domain inhibits the intrinsic guanine nucleotide exchange activity of p115., Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG)., Thromboxane receptor signaling is required for fibronectin-induced matrix metalloproteinase 9 production by human and murine macrophages and is attenuated by the Arhgef1 molecule., Upon beta(2)AR activation, both betaArrestin2 and p115RhoGEF translocate to the plasma membrane, with concomitant activation of RhoA and formation of focal adhesions and stress fibers., Activation of p115-RhoGEF requires direct association of Galpha13 and the Dbl homology domain., High GEF1 expression is associated with metastasis of pancreatic cancer., The action of DOCK7 in vivo may involve the coordinated integration of Cdc42/Rac1 signaling in the context of the membrane recruitment of a DOCK7 guanine nucleotide exchange factor (GEF) complex., Modification of p115RhoGEF at Serine(330) regulates its RhoGEF activity., The novel role for p115RhoGEF in regulation of epithelial plasticity is dependent on Rho-DRF signaling module., Regulated localization is sufficient for hormonal control of regulator of G protein signaling homology Rho guanine nucleotide exchange factors (RH-RhoGEFs)., contactin-1 displayed the ability to phosphorylate the RhoA activator p115 RhoGEF,
OFFICIAL_GENE_SYMBOL arhgef1,
SP_COMMENT domain:The DH domain is involved in interaction with CCPG1., domain:The RGSL domain, also known as rgRGS domain, is necessary but not sufficient for GAP activity., function:Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12., PTM:Phosphorylated by PKCA., sequence caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part., similarity:Contains 1 DH (DBL-homology) domain., similarity:Contains 1 PH domain., similarity:Contains 1 RGSL (RGS-like) domain., subcellular location:Translocated to the membrane by activated GNA13 or LPA stimulation., subunit:Interacts with RHOA, GNA12 and GNA13. Homooligomerizes through the coiled coil region. May interact with CCPG1 (By similarity). Interacts with CTNNAL1., tissue specificity:Ubiquitously expressed.,