Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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Wnt family member 3A(WNT3A) Wnt family member 3A(WNT3A) Related Genes Homo sapiens
GENERIF_SUMMARY Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45, Clustered with WNT14 on 1q42., wnt3a-beta catenin signaling regulates LEF-1 gene expression, CKI epsilon-dependent phosphorylation of Dvl enhances the formation of a complex of Dvl-1 with Frat-1 and this complex leads to the activation of Wnt-3a-induced accumulation of beta-catenin, These results suggest that Wnt responsiveness is a stage-specific phenomenon in B-cell development and that the morphological changes associated with Wnt signaling may play a role in the motility and metastatic potential of myeloma cells., Results suggest that disabled-2 functions as a negative regulator of canonical Wnt signaling by stabilizing the beta-catenin degradation complex., Wnt3a may stimulate a cellular phosphatase to dephosphorylate and activate CKIepsilon, Wnt/beta-catenin pathway activation by Wnt3a raised beta-catenin in monocytes & decreased migration thru a dermal microvascular endothelial cell layer. This was associated with specific monocyte adherence to endothelial cells after Wnt3a exposure., BMP-2 antagonizes Wnt-3a signaling in osteoblast progenitors by promoting an interaction between Smad1 and Dvl-1 that restricts beta-catenin activation, ILK activity can modulate acute Wnt3a mediated beta-catenin phosphorylation, stabilization and nuclear activation in a PI3K-independent manner., Wnt-LRP5 signalling may play a role in the adaptation of bone to mechanical load in humans, and may explain some gender-related differences in bone mass, Over-expression of the Wnt3a gene significantly enhances the ability of fibroblast feeder cells to support the undifferentiated growth of 3 different human embryonic stem cell lines., Wnt3A/5A can function as mesenchymal regulatory factors by providing instructive cues for the recruitment, maintenance, and differentiation of mesenchymal stem cells., Wnt3A treatment significantly activated human hepatic stellate cells, while this was inhibited in secreted frizzled-related protein 1 (sFRP1) overexpressing cells., These results suggest that Wnt signaling crosstalk and functional antagonism with the LRP5 co-receptor are key signaling regulators of mesenchymal stem cells maintenance and differentiation., Blockade of Wnt3a stimulation of IP(5) generation blocks beta-catenin accumulation, Results identify a novel feedback mechanism by which Wnt, including Wnt3a, negatively regulates LRP6 at the mRNA level., These findings demonstrate a requirement of Wnt signaling for maintenance, proliferation, and survival of NP when cultured in neurosphere conditions., Wnt3a markedly reduced the forskolin-induced expression of RANKL, a target gene of PTH/cAMP/PKA., Our results suggest that Wnt/beta-catenin signaling plays important roles in human fetal skin development and homeostasis, which also provide new insights on the molecular mechanisms of oncogenesis in human epidermis., bone marrow sera from 21 multiple myeloma patients significantly suppressed Wnt3a-induced OPG expression and enhanced RANKL expression in osteoblasts in a DKK1-dependent manner, effect of Wnt3a on bone disease and growth of multiple myeloma cells in vitro and in vivo, study demonstrated that Wnt3a & Wnt5a can promote proliferation of HEK293 cells & inhibit serum starvation-induced apoptosis, which implies Wnt3a & Wnt5a can maintain survival of HEK293 cells under stress, FGF antagonizes Wnt signaling by inhibiting Wnt-induced transcription and suggest that multiple mechanisms, including downregulation of TCFs and Wnt receptors, contribute to this effect., glutamine synthetase has a role in control of glutamate signalling through Wnt3A and steroid pathways in osteoblastic cells, both Wnt5a and Wnt3a bound Ror2, only Wnt5a induced Ror2 homo-dimerization and tyrosine phosphorylation in U2OS human osteoblastic cells., Wnt3a and Wnt5a have roles in inducing BMP-4 and 6 expression in prostate cancer osteoblast differentiation, essential role of Wnt3a in hepatocyte differentiation from hESCs; Wnt3a facilitates clonal plating of hESCs exhibiting functional hepatic differentiation, the frequent loss of stromal TGF-beta type II receptor expression in prostate cancer can relieve the paracrine suppression of Wnt3a expression, These findings suggest that WNT3A can mediate transcriptional changes in melanoma cells in a manner reminiscent of the known role of Wnt/beta-catenin signaling in normal melanocyte development., Our study reveals an unappreciated role for noncanonical Wnt signaling in hESC specification that involves development of unique mesoderm precursors via morphogenic organization within human EBs., The presence of WNT3a completely prevents normal adipocyte differentaiton., Wnt3a induces canonical and non-canonical Wnt signaling in HUVECs, and stimulates their proliferation and migration., Data show that mutated GPC3 lacking the GPI anchoring domain (sGPC3) significantly inhibited the in vivo growth, blocked Wnt signaling and Erk1/2 and Akt phosphorylation in tumors., Wnt3A treatment greatly enhanced the effect of LRP6 on T-cell factor/lymphoid enhance factor luciferase activity in human mammary epithelial cells, Wnt-3A may activate canonical Wnt signaling and PI3K/AKT through distinct receptors., Data demonstrate that the Wnt-beta-catenin signaling pathway is functional in platelets, and that a Wnt3a ligand inhibits platelet adhesion, activation, dense granule secretion, and aggregation., Wnt/beta-catenin pathway activation might upregulate DIXDC1 through a post-translational mechanism by inhibiting the ubiquitin-mediated degradation of the DIXDC1 protein., analysis of the frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6, Loss of CYLD instigates tumor growth in human cylindromatosis through a mechanism in which hyperubiquitination of polymerized Dvl drives enhancement of Wnt3/beta-catenin responses., Studies indicate that understanding the contributions of Notch, Wnt and HH signaling to the development of hematopoiesis is critical for achieving successful ex vivo expansion and differentiation of hematopoietic stem cells hematopoietic stem cells., EP2 is a novel transcriptional target of Wnt3a in dermal papilla cells of human scalp hair follicles, up-regulation of DPAGT1 transcripts by Wnt3a led to altered N-glycosylation of E-cadherin., These results support sFRP2's role as an enhancer of Wnt3A/beta-catenin signaling, a result with biological impact for both normal development and diverse pathologies such as tumorigenesis., Wnt-3a increases neurogenesis during the differentiation of ReNcell VM cells. Neurogenesis induced by Wnt-3a is independent of the transcriptional activity of Wnt/beta-catenin pathway in ReNcell VM cells., two SNPs of Wnt3A (rs752107 and rs3121310) are significantly associated with NSCLP in Chinese population. These findings provide a context for understanding the genetic aetiology of NSCLP., Forced expression of C4ST-1 in L-Wnt-3a cells inhibited diffusion of Wnt-3a due to structural alterations in CS chains mediated by C4ST-1., These results provide strong evidence that the centrosomal localization of CK1delta is required for Wnt-3a-dependent neuritogenesis., WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways, The genetic variants of WNT3A gene may not be associated with the susceptibility to congenital scoliosis in a Chinese Han population., Results indicate that CK1 isoforms work coordinately to promote the full response to Wnt3a stimulus., In HEK293T cells with intact Wnt signaling, Rac1b is tethered to these same gene promoters independent of Wnt3A stimulation and is further observed to recruit Dishevelled and beta-catenin in the absence of Wnt3A stimulation., when released from E-cadherin by Wnt3a-stimulated phosphorylation, p120-catenin controls the activity of Kaiso, enhancing its binding to repressed promoters and relieving its inhibition of the beta-catenin-Tcf-4 transcriptional complex., Recombinant Sox17 prevents Wnt3a from repressing myelin protein expression, while inhibition of Sox17-mediated proteasomal degradation of beta-catenin blocks myelin protein induction., Wnt3a signalling is upregulated in keloid fibroblasts and this promotes cellular growth, migration and extracellular matrix production in such fibroblasts., HCV core protein enhances Wnt/beta-catenin signaling activity, hence playing an important role in HCV-associated carcinogenesis, Combining BMP4/WNT3A induction and OCT4/EpCAM selection can significantly increase the putative germ cell population with meiotic competency., Growth inhibition of magnolol against human colon cancer cells can be partly attributed to the regulation of the Wnt3a/beta-catenin signaling pathway., WNT-3a as a novel upstream regulator of small GTPase activity in platelets, Studies indicate he role of Wnt3a in osteoarthritis (OA)has been well investigated as its activity is reduced in OA., WNT3A putatively associates with primary osteoporosis., CPE forms a complex, probably through sequences located at its N-terminal domain, with Wnt3a and the extracellular cysteine rich domain of Fz1., Wnt3a can induce epithelial-mesenchymal transition, migration, and proliferation of human lens epithelial cells, and may be a valuable therapeutic target for the prevention and treatment of posterior capsular opacification., overexpression of Wnt signaling pathway is associated with malignant breast cancer., During cell differentiation Wnt3a regulates Nkx2.5 and inhibits cardiomyogenesis., human bronchial epithelial cells are able to undergo epithelial-mesenchymal transition in vitro upon nicotine stimulation via the Wnt3a/beta-catenin signaling pathway., The skin lesions of scleroderma patients showed obviously increased expression of cytoplasmic Wnt 2, nuclear Wnt 3a and beta-catenin, but markedly lowered cell membrane expression of beta-catenin than normal skin., WNT3A promoted MSC proliferation via the ss-catenin-mediated canonical Wnt pathway, and inhibited chondrogenesis of mesenchymal stem cells via the calcium/calmodulin-dependent kinase II (CaMKII)-mediated non-canonical Wnt pathway., Wnt3a mediates activation of Wnt/beta-catenin signaling and promotes tumorigenesis and tumor growth in experimental glioblastoma., results indicate that SCN-iPS cells provide a useful disease model for SCN, and the activation of the Wnt3a/beta-catenin pathway may offer a novel therapy for SCN with ELANE mutation, Wnt-induced dishevelled 2 phosphorylation has effects in in canonical and noncanonical Wnt3a and Wnt5a signaling, site-specific Dvl2 phosphorylation is required for Dvl2 association with PKCiota; this interaction is likely to be one of the mechanisms essential for Wnt3a-dependent neurite outgrowth, In ankylosing spondylitis patients, Wnt-3a serum levels are lower in the high activity group compared to low activity group and controls., Paracrine Wnt signaling both promotes and inhibits human breast tumor growth., a new role for Ror2 in conveying a tonic signal to stabilize soluble beta-catenin and create a poised state of enhanced responsiveness to Wnt3a exogenous signals in RCC., The activation of effector T cells increased Wnt3a production, and Wnt3a levels were found to be greatly increased in mononuclear cells isolated from synovial fluid versus peripheral blood of arthritis patients., Data suggest that activation of Wnt signaling pathway in rhabdomyosarcoma via Wnt3a involves reduced phosphorylation of CTNNB1 (catenin beta-1), stabilization of active cytosolic CTNNB1, and nuclear translocation of CTNNB1., WNT3A alone was a poor inducer of mesoderm from hESCs in defined medium. WNT3A and BMP4 synergized to accelerate mesoderm formation. Added later, WNT3A blocked hematopoiesis and generated mesenchymal colonies., High Wnt3A expression is associated with metastasis in triple negative breast cancer., Data show that beta-arrestins regulate Wnt3a-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation by the regulation of the membrane dynamics of Amer1., Wnt3a inhibited the apoptosis of mouse embryonic liver stem cells, results demonstrate that, while ER signaling acts synergistically with Wnt3A in promoting osteogenic differentiation, Wnt3A may crosstalk with ER signaling by up-regulating ERalpha expression and down-regulating ERbeta expression in MPCs., Negative modulation of cilia assembly and trafficking by IFT88 siRNA increases canonical wnt signaling in response to wnt3a., these results show that TAZ mediates Wnt3a-stimulated osteogenic differentiation through PP1A, suggesting that the Wnt signal regulates the Hippo pathway., Wnt3a expression is high in the tumor environment; the protein is found in over 50% of primary tumors, but the prevalence is lower in tissue from colorectal cancer metastatic sites., SNP rs752107 in WNT3A was strongly associated with decreased total hip BMD showing the highest significance under the recessive model, Application of recombinant Wnt3a showed an anti-proliferative effect on keratinocytes in a dose-dependent manner., WNT3A gene expression is associated with isolated Hirschsprung disease polymorphism and disease status., Mutation of any individual cysteine of Wnt3a results in covalent Wnt oligomers through ectopic intermolecular disulfide bond formation and diminishes/abolishes Wnt signaling., Wnt3a recruits the Wnt-calcium signaling pathway in peripheral nerves in a pain model., The LRP6 tyrosine mutant increased in signaling activation in response to Wnt3a/beta-catenin stimulation., p66(Shc) plays a vital part in canonical Wnt signaling in the endothelium and mediates Wnt3a-stimulated endothelial oxidative stress and dysfunction., miR-195 is key in regulating cell proliferation, cell cycle and apoptosis through targeting Wnt3a., High WNT3A expression is associated with glioblastoma., High WNT3A expression is associated with bone destruction in lung and breast cancer., The interaction between Wnt isoforms and their LRP6 cognate receptor depends on the jutting loop present in Wnt3a but absent in Wnt5b., Wnt3a expression was associated with epithelial mesenchymal transition and promoted colon cancer progression., a Wnt-amplified environment was associated with superior pulp healing., Wnt3a and Notch3 may promote the metastasis of non-small cell lung cancer and Notch3 upregulation is required for the Wnt3a mediated increased metastatic abilities of non-small cell lung cancer., These observations demonstrated the first time that Wnt3a can directly activate MyoD expression through targeting cis-elements in the DE and the L fragment., Wnt-mediated protein stabilization ensures proper mitotic microtubule assembly and chromosome segregation., Wnt3a can modulate intracellular localisation and secretion of sFRP4., 72 Wnt target genes higher expressed in triple-negative breast cancer, Upregulated Wnt3a in colon cancer cells promoted the capacity to form tube-like structures in the three-dimensional (3-D) culture together with increased expression of endothelial phenotype-associated proteins such as VEGFR2 and VE-cadherin., The results reveal a novel inhibitory role of Wnt3a on canonical Wnt/beta-catenin signaling and cancer cell proliferation when there is an insufficient blood supply during tumor development., The pool of ADP-ribosylated Axin, which is degraded under basal conditions, increases immediately following Wnt stimulation in both Drosophila and human cells.,
SP_COMMENT function:Ligand for members of the frizzled family of seven transmembrane receptors., function:Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube., similarity:Belongs to the Wnt family., subunit:Interacts with PORCN., tissue specificity:Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate.,