Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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WAS protein family member 1(WASF1) WAS protein family member 1(WASF1) Related Genes Homo sapiens
CHROMOSOME 6,
CYTOBAND 6q21-q22,
ENSEMBL_GENE_ID ENSG00000112290,
GENERIF_SUMMARY Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck, Results suggest that recruitment of factors by Wiskott-Aldrich Syndrome protein (WASP) and Scar1 stimulates cellular actin-based motility and actin nucleation with the Arp2/3 complex., WAVE1 may act as a scaffold to recruit the NADPH oxidase to a complex involved with both cytoskeletal regulation and downstream JNK activation, the 3 WAVE isoforms exhibit common and distinct features and may potentially be involved in the regulation of actin cytoskeleton in platelets, Dictyostelium discoideum has been used to remove genetically SCAR complex members to ascertain their specific roles., WAVE-1 expression was associated with megakaryocytic differentiation; WAVE-1 and WAVE-2 moved from a detergent-soluble cytosolic fraction to insoluble cytoskeleton fraction after platelet aggregation, NESH (Abi-3), like Abi-1 and Abi-2, is a component of the Abi/WAVE complex, but likely plays a different role in the regulation of c-Abl., the Hem-1/Nap1 component of the Scar/WAVE complex localizes to propagating waves that appear to organize the leading edge of a motile neutrophil, WAVE1 is critical for formation of oligodendrocyte lamellae and myelin sheaths--REVIEW, WAVE1 is involved in multi-drug resistance through regulation the level of mdrl and Bcl-2., WAVE1 dephosphorylation and activation are likely associated with mitochondrial redistribution and dendritic spine morphogenesis., Results suggest that WAVE and the Arp2/3 complex jointly orchestrate different types of actin-based plasma membrane protrusions by promoting ruffling and inhibiting mDia2-induced filopodia., The WAVE1 expression increased in children with ALL. WAVE1 may be related to the development of ALL and may be severed as a marker for the evaluation of the severity of ALL in children., Dimerization act in hierarchical fashion, enabling WASP/WAVE proteins to integrate different classes of inputs to produce a wide range of cellular actin responses in Wiskoo Aldrich syndrome., WAVE1 and p22phox expression in PBMCs increased and was associated with the disease course in children with acute lymphocytic leukemia (ALL)., WAVE accumulation may be involved in Abeta/amyloid precursor protein mediated-tangle modification, CIP4 is a new ArgBP2 interacting protein that modulates the ArgBP2 mediated control of WAVE1 phosphorylation and cancer cell migration., WAVE1 might be involved in the migration and invasion of K562 cells through regulation of the expression level of MMP-2., WAVE1 regulates Bcl-2 localization and phosphorylation in leukemia cells., Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex, Higher levels of WAVE1 in the bone marrow indicate an unfavorable prognosis in children with AML., Arf GTPases may be central components in WAVE signalling, acting directly, alongside Rac1., mDia1 and WAVE2 are important Src homology 3 domain partners of IRSp53 in forming filopodia., Study finds that WAVE1 overexpression is associated with an unfavorable prognosis. WAVE1 is an independent prognostic factor for EOC, which suggests that it is a novel and crucial predictor for EOC metastasis., Scar/WAVE regulatory complex and N-WASP play opposing roles in 3D epithelial cell migration, mRNAs encoding structural and regulatory components of the WAVE complex are localized to the leading edge of the cell, suggesting that localized protein synthesis plays a pivotal role in controlling cell spreading and migration., WAVE1 might promote the proliferative and invasive malignant behaviors through the activation of the PI3K/AKT and p38MAPK signaling pathways in epithelial ovarian cancer., D620N mutation in VPS35 restricts WASH complex recruitment to endosomes, and reveals a novel role for the WASH complex in autophagosome formation., The WAVE complex is the main activator of the Arp2/3 complex for actin filament nucleation and assembly in the lamellipodia of moving cells., WAVE1 has unique activities independent of Arp2/3 complex that can govern both the growth rates and architectures of actin filament networks. Elongation inhibitory effects of WAVE1 were mapped to its WH2 ("V") domain., a role for ARF6 in linking EGF-receptor signaling to Rac1 recruitment and activation at the plasma membrane to promote breast cancer cell directed migration, we propose that WASF1 status defines a subtype of androgen deprivation therapy -resistant prostate cancer patients, A decrease in amounts of WASF1 mRNA was also observed in human Alzheimer's disease brains, suggesting clinical relevance of the negative feedback circuit involved in homeostatic regulation of Abeta production,
SP_COMMENT domain:Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain., function:Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton., similarity:Belongs to the SCAR/WAVE family., similarity:Contains 1 WH2 domain., subcellular location:Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas., subunit:Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1 (By similarity). Binds actin and the Arp2/3 complex. Interacts with BAIAP2., tissue specificity:Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood.,