Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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caveolin 1(CAV1) caveolin 1(CAV1) Related Genes Homo sapiens
CHROMOSOME 7,
CYTOBAND 7q31.1,
ENSEMBL_GENE_ID ENSG00000105974,
GENERIF_SUMMARY Caveolin-1 expression enhances endothelial capillary tubule formation, CAV1 was found in liver endothelial cells and in Kupffer cells (liver non-parenchymal cells)., forms a cholesterol complex and transports it from the endoplasmic reticulum to the cell membrane; activates signal transduction molecules, over-expression is associated with lymph node metastasis and worse prognosis after surgery in esophageal squamous cell carcinoma, Neu3 functions as a caveolin-related signaling molecule within caveolin-rich microdomains, Data show that ER alpha and not ER beta silences caveolin-1/-2 expression in an epigenetic fashion in neuronal cells., Some protein tyrosine phosphatases form molecular complexes with caveolin-1 in lipid rafts, regulation of expression and secretion by a protein kinase c epsilon signaling pathway in human prostate cancer cells, data show that coexpression of caveolin can markedly inhibit expression of HIV proviral DNA and establish that the inhibition is mediated by the hydrophobic, membrane-associated domain, Data show that IL-6/raft/STAT3 signaling is a chaperoned pathway that involves caveolin-1 and HSP90 as accessory proteins and suggest a mechanism for the preservation of this signaling during fever., both the caveolin-1/EGFR association and EGF-induced tyrosine phosphorylation of caveolin-1 are modulated by ganglioside GM3, Endostatin associates with integrin alpha5beta1 and caveolin-1, and activates Src via a tyrosyl phosphatase-dependent pathway in human endothelial cells., data clearly implicate loss of functional Cav-1 in the pathogenesis of mammary epithelial cell hyperplasia, Caveolin-1 phosphorylation in human squamous cell carcinoma is dependent on ErbB1 expression and Src activation., In the cerebral cortex caveolin-1 is expressed by all the cell types that form the vascular wall, endothelial cells, pericytes, and vascular astrocytes in vivo., Up-regulated caveolin-1 accentuates the metastasis capability of lung adenocarcinoma by inducing filopodia formation., basal and SR-BI-stimulated free cholesterol efflux to HDL and liposomes and SR-BI-mediated selective uptake of HDL cholesteryl ester are not affected by caveolin-1 expression, Caveolae plays a role in signal-transducing function of cardiac Na+/K+-ATPase., caveolin-1 may play a role in lamellar granule assembly, trafficking, and/or function., interacts with endothlin b receptor, ERalpha co-activator caveolin is negatively regulated by the steroid receptor itself, Caveolin-1 may modify the biosynthetic pathway of sugar chains via the regulation of the intra-Golgi subcompartment localization of N-acetylglucosaminyltransferase III, caveolin has a role in recovery from cell sensecence, Caveolin-1 contributes to assembly of store-operated Ca2+ influx channels by regulating plasma membrane localization of TRPC1., Caveolin-1 expression is an independent positive prognostic factor for survival in extrahepatic bile duct carcinoma., A statistically significant difference in the expression of caveolin-1 between oncocytoma with a mean labeling index of 91.7 and other malignant renal tumors with a lower mean labeling index possibly implicates this peptide in oncocytoma pathogenesis., PPARgamma & caveolin-1 may coexist in a complex. PPARgamma participates in the regulation of caveolin gene expression in human carcinoma cells. Caveolin-1 may mediate some of the phenotypic changes induced by PPAR-G in cancer cells., Caveolin-1 is an inhibitor of platelet-derived growth factor (PDGF) proliferative responses and might be capable of transforming PDGF-induced proliferative signals into death signals., CAV-1 gene can be inactivated through mutations and does not play a role in the development of cervical cancer, cytoplasmic overexpression of caveolin-1 predicts a poor prognosis in renal cell carcinoma, Akt activities are largely responsible for cav-1-mediated cell survival, caveolin-1 has a role in mediating astrocyte responses to MCP-1, negative regulation of caveolin-1 plays a central role in the complex cellular changes leading to metastasis, caveolin-1 associates with CD147, in a complex distinct from CD147-alpha(3) integrin complexes, thereby diminishing both CD147 clustering and CD147-dependent MMP-1-inducing activity, inactivation of Caveolin-1 by a mutation or by reduced expression may play a role in the pathogenesis of oral cancer, overexpression of caveolin-1 in hepatic cells stimulates cholesterol efflux by enhancing transfer of cholesterol to cholesterol-rich domains in the plasma membrane., Ouabain assembles signaling cascades through the caveolar Na+/K+-ATPase., Cav-1 haploinsufficiency in human breast epithelial cells can lead to partial transformation., Nitric oxide concentrations could impact on capillary formation via a combination of direct effects on MMP activation and by altering the distribution or abundance of Cav-1 in tumor angiogenesis., caveolin-1 is overexpressed in experimental colon adenocarcinoma by comparison to adjacent normal mucosa, and its expression in human colon cancer cells is directly associated with the growth rate, Cav-1 has a role in regulating the functional activity of 5-HT(2A) serotonin receptors and Galpha(q)-coupled receptors, caveolin-1 can inhibit the conversion of LG-CD147 (low glycoform-CD147) to HG-CD147 (high glycoform-CD147), Results suggest different roles for CAV1 in SCLC, where CAV1 acts like a tumor suppressor gene, and NSCLC, where it appears required for survival and growth., phosphorylation was found in both the acetylated and non-acetylated variants of caveolin-1beta. This variability in modifications is consistent with critical involvement of the N-terminal domain of caveolin in the regulation of caveolae, review of coordination of caveolin-1 gene expression regulation with that of MDR1 in cancer cells, In four different groups of marrow samples (20 normal, 56 acute myeloid leukemias (AML) at diagnosis, 48 AMLs at relapse, and 51 regenerating marrows), caveolin-1 and MDR-1 gene expressions were positively correlated, Our data demonstrate for the first time that the reduction of the plasma membrane cholesterol level induced by overexpressing caveolin-1 may indirectly inhibit P-gp transport activity by increasing plasma membrane fluidity., caveolin-1 plays an important role in senescence-associated morphological changes by regulating focal adhesion kinase activity and actin stress fiber formation in the senescent cells., Aberrant promoter methylation of the caveolin-1 gene may occur at the precancerous stage, regulated by gender-related factors and is associated with gene silencing of caveolin-1 in the development of colorectal cancer., a functional peroxisome proliferator response element in the cav-1 promoter is activated upon rosiglitazone treatment in THP-1 macrophages, Caveolin-1 regulates primary breast tumor growth and spontaneous metastasis of breast cancer., results suggest that CD26-caveolin-1 interaction plays a role in the up-regulation of CD86 on TT-loaded monocytes and subsequent engagement with CD28 on T cells, leading to antigen-specific T cell activation, role of aberrant promoter methylation in the regulation of caveolin-1 gene in breast cancer correlated with clinical findings, caveolin-1 expression was increased upon induction or over-expression of FOXO factors at both mRNA and protein levels, association of MT1-MMP with phosphorylated caveolin-1 occurs in caveolae membranes and involves the cytoplasmic domain of MT1-MMP, Caveolin-1 and MAL are located on prostasomes secreted by prostate cancer cells, Caveolin-1 clusters at cell-cell contacts after assembly of alpha-hemolysin into heptameric oligomers, facile penetration of alpha-HL's beta-barrel might occur through protein-protein interactions with the surrounding 7 alpha-helices of Caveolin-1, Overexpression of caveolin-1 in mesangial cells suppresses MAP kinase activation and cell proliferation induced by bFGF and PDGF, two major cytokines in mesangioproliferative nephritis(MN). Caveolin-1 expression vector is potential therapy for MN., potential role of caveolin polarity in lamellipod extension and cell migration., identiication of KLF11 as a dominant repressor of calveolin-1 gene, The caveolin 1 was found in the endothelial cells of 10-week-old human placenta., Caveolin-1 in human breast cancer cells enhances matrix-independent cell survival that is mediated by upregulation of IGF-I receptor expression and signaling., Caveolin-1 inhibits the activation of BMP type IA receptor in preformed hetero-oligomer complexes by binding to BMP type II receptor., caveolin-1 (CAV-1) functions as a scaffolding protein for phosphofructokinase (PFK), Results demonstrate that a branched signaling pathway involving MEK, ERK, PKCepsilon, PKCalpha, and caveolin-1 regulates collagen expression in normal lung tissue and is perturbed during fibrosis., Actin cytoskeleton is involved as part of a caveolar complex in the regulation of myometrial maxi-K channel function., The downregulation of caveolin-1 in HCT 116 cells inhibited degradation of the extracellular matrix protein collagen IV and the invasion of these cells through Matrigel., When we overexpressed caveolin-1 in young mesenchymal stem cells, not only insulin signaling but also adipogenic differentiation was significantly suppressed with down-regulated PPARgamma2., caveolin regulates the inhibition by cell-bound TFPI of the active protease production by the extrinsic pathway of coagulation, This is the first report providing evidence for CAV-1 being involved in predisposition to aggressive prostate cancer, unique features of CAV1 phosphorylation on oxidative stress observed implicate an important role of CAV1 in placental endothelial cell biology during pregnancy., increased expression of caveolins in proliferating bile ductules in primary biliary cirrhosis may be related to the homeostasis of cholesterol transport in regenerating bile ductules in liver, Cav-1 expression inhibits ras homolog gene family, member C GTPase activation and subsequent activation of the p38 MAPK pathway in primary pancreatic cancer cells thus restricting migration and invasion, Caveolin-1 is more expressed in cancer tissues than normal colon and related with Akt-1, not with Epidermal Growth Factor Receptor expression in colorectal cancer tissues, which suggests that signaling for caveolin-1 affects Akt-1 activation., These results suggest that caveolae could represent an intracellular site that contributes to differentiate IR and IGF-IR activity, and demonstrate the role of caveolin-1 in the eNOS activation by Insulin and IGF-I., Overexpression of caveolin-1 is associated with inflammatory breast cancer, data suggest that caveolin-1 expression indirectly promotes cell-cell adhesion in ovarian carcinoma cells by a mechanism involving inhibition of src-related kinases, structure activity relationship, CAV1 is down-regulated and inversely correlated with HER2 and EGFR expression status in DCIS of the breast., aberrant methylation and abnormal protein expression of the caveolin-1-gene is involved in the formation of nonurothelial carcinomas of the urinary bladder, EGF-based signaling cascades phosphorylate Cav1 and have roles in caveolae assembly, It is therefore concluded that caveolin-1 facilitates the hypotonicity-induced release of Cl(-), taurine, and ATP., These novel findings provide insight into possible signaling mechanisms of Nf1 and suggest that together Nf1 and Cav-1 may coordinately regulate cell growth and differentiation., Epidermal growth factor receptor exposed to oxidative stress undergoes Src- and caveolin-1-dependent perinuclear trafficking, Two clones of cells expressing caveolin-1 were investigated for their lipoprotein metabolism activity, showing an increase in ldl liprotein degradation and an increase in HDL lipoprotein activity., Cell-cell contact is required for BeWo trophoblasts to exhibit plasmalemmal caveolin-1., interacts with rotavirus NSP4 and contributes to NSP4 intracellular trafficking from the endoplasmic reticulum to the cell surface., CAV1 has a role in both hereditary and sporadic breast cancer, Expression of caveolin is sufficient to drive the formation of caveolae in cell lines normally lacking caveolin, such as human colon cancer cells (Caco-2)., The 22285 C-22375-22375 del (Cd) haplotype of CAV1 gene, but not the NOS3-CAV1 interaction, is associated with low levels of blood pressure and protects against metabolic syndrome, Results suggest that anti-proliferative and pro-apoptotic properties of caveolin-1 may be attributed to reduced survivin expression via a mechanism involving diminished beta-catenin-Tcf/Lef-dependent transcription., Homocysteine induced impairment of nitric oxide production through through a modulation of Caveolin-1 expression., As such, caveolae and caveolin-1 coordinate PDGF receptor signaling, leading to myocyte proliferation, and inhibit constitutive activity of p42/p44 MAPK to sustain cell quiescence., PSMA binds to caveolin-1 and undergoes internalization via a caveolae-dependent mechanism in microvascular endothelial cells, Cav-1-deficient mammary acini displayed increased ERalpha levels and enhanced sensitivity toward estrogen-stimulated growth, with specific up-regulation of cyclin D1, important roles for VCAM-1 and Caveolin- 1 in the regulation of metastatic potential of gastric tumor cells, A ternary complex between NOSTRIN, caveolin-1, and eNOS mediates translocation of eNOS, with important implications for the activity and availability of eNOS in the cell., CAV1, either alone or together with eNOS alleles, might modify colorectal cancer heritability., Thus, these results demonstrate a crucial role of caveolin-1 scaffolding domain interaction with TRPC1 in regulating Ca2+ influx via SOC., Increased immunoexpression of the Cav-1 seems to be associated with the biological aggressiveness of meningiomas, reflecting a worse prognosis., Inhibits apoptosis and promotes survival signaling in cancer cells., the Sprouty/Caveolin-1 interaction modulates signaling in a growth factor- and Sprouty isoform-specific manner, Breast cancer patients with higher caveolin-1 expression may benefit from ABI-007 therapy., caveolae and caveolins are integral membrane components in basal and ciliated epithelial cellsin rats, mice, and humans, indicating a crucial role in these cell types; in addition to their physiological role, they may be involved in airway infection, Results describe the expression of caveolin-1 in human fetal tissues during mid and late gestation., The interaction of the GLP-1R with caveolin-1 regulates subcellular localization, trafficking, and signaling activity., Cav-1 induced the cytoplasmic sequestration of BRCA1., transcriptional activation of the IGF-IR gene by Cav-1 requires an intact p53 signaling pathway, Loss of CAV1 expression inhibited the anchorage-independent growth of EWS cells and markedly reduced the growth of EWS cell-derived tumors in nude mice xenografts, indicating that CAV1 promotes the malignant phenotype in EWS carcinogenesis., The role of caveolin-1 as a factor contributing to the severity of the tubulointerstitial process resulting from obstructive nephropathy could be suggested., Results indicate a pivotal role for cav-1 in the regulation of extracellular matrix production and suggest a novel therapeutic target for patients with pulmonary fibrosis., activated EGF receptor transiently modulates integrin alpha2 cell surface expression and stimulates integrin alpha2 trafficking via caveolae/raft-mediated endocytosis, CAV1 phosphorylation on Tyr-14 increases the induction of apoptosis by taxanes in breast cancer cells., the Cav-1 scaffolding domain bound significantly to the gp41 expressed in mammalian cells, Caveolin 1 has a role in progression of a subset of basal-like and metaplastic breast carcinomas, Prolonged stimulation of isolated human thyrocytes by TSH/cAMP/cAMP-dependent protein kinase inhibits caveolin-1 expression., overexpression of caveolin-1 overcame the VEGF-mediated inhibition of adhesion and restored ICAM-1 clustering, Caveolin-1, as a negative regulator of endothelial cell proliferation, may be a potential target for the control of angiogenesis., role of caveolin-1 in preventing ischemia-reperfusion injury, These results suggest that caveolin-1 regulates GD3-mediated malignant signals by altering GD3 distribution and leading edge formation, Ligation of CD26 by caveolin-1 recruits a complex, including CD26 and CARMA1, which functions in lymphocyte activation., Over-expression of Caveolin-1 was associated with established features of prostate cancer and aggressive PSA recurrence., This review suggests that caveolin-1 plays an essential role in regulating liver regeneration and that it is implicated in regulation of triglyceride accumulation, an essential process that plays a critical role in the regulation of liver regeneration., Aberrant methylation of CAV1 is associated with hepatocellular carcinoma, These data suggest that in ovarian carcinoma cells cav-1, localized in transcriptionally inactive chromatin, exerts a functional activity mediated, at least in part, by directly binding to sequences of genes involved in proliferation., the rotavirus NSP4 binding site was localized to caveolin-1 residues 2-22 and 161-178, at the amino- and carboxyl-termini, respectively, among astroglial tumors cav-1 expression varies in distribution, pattern & intensity specifically according to tumor types & grades, These data suggested that loss of caveolin-1 is associated with abnormal re-epithelialization in lung fibrosis., glucocorticoids modulate the expression of caveolin-1 and caveolae biogenesis within alveolar epithelial cells via both transcriptional and translational modifications, Appropriate caveola-membrane organization by caveolin-1 and detection of estrogen receptor beta in the plasma membrane are directly reflected by MAP kinase phosphorylation and consequent vitamin D receptor expression., Results indicated that caveolin-1 expression may have potential both as a diagnostic marker in the differential diagnosis of renal tumors and as a therapeutic target, especially for clear-cell renal cell carcinoma., EMP2 regulates caveolin-1 transcription and more substantially its protein levels., The presence of different caveolin isoforms in many cell types of the human retina, is reported., HPV type 31 (HPV31) entry and initiation of early infection events require both caveolin 1 and dynamin 2 and occur independently of clathrin-mediated endocytosis., Downregulation of caveolin-1 expression affects bleomycin-induced cell cycle arrest and subsequent cellular senescence that is driven by p53 and p21., Positive staining resulted in shorter survival in patients with esophageal squamous cell carcinoma., Data suggest that Cav-1 down-modulation might function as a permissive mechanism, which, by unleashing c-Src and Met signaling, enables osteosarcoma cells to invade neighboring tissues., These positive correlations provide new evidence for the involvement of prostate cancer cell derived cav-1 in mediating angiogenesis during prostate cancer progression., These internalization data were highly suggestive of the predominant use of the clathrin-mediated pathway by NK1-R, even though NK1-R tended to reside constitutively in lipid raft/caveolae microdomains., Re-expression of E-cadherin in HT29(US) cells restored the ability of caveolin-1 to down-regulate beta-catenin-Tcf/Lef-dependent transcription and survivin expression, as seen in HT29(ATCC) cells., The present data suggest that promoter methylation of the 14-3-3 sigma and CAGE-1 genes plays a crucial role during the phenotypical morphogenesis of vesical adenocarcinomas including signet ring cell carcinomas by an epigenetic mechanism., Findings show for the first time the upregulation of mRNA CAV-1 expression levels in VAT and SAT of obese NG and obese T2DM patients compared with lean controls, suggesting a role for CAV-1 in obesity and T2DM development., PAR1 localization in the caveolin-enriched membrane microdomain, bound to caveolin-1, represents a crucial requirement for TF induction in endothelial cells., Our studies indicate that the conformational changes are probably initiated at the Caveolin-1 binding moti., COX-2 is localized within caveolae compartment and colocalized with CAV-1 protein in lobular intraepithelial neoplasia of the breast., caveolin-1 is a novel Id-1 binding partner that mediates the function of Id-1 in promoting prostate cancer progression through activation of the Akt pathway leading to cancer cell invasion and resistance to anticancer drug-induced apoptosis, Caveolin-1 was expressed in the sinusoidal endothelial cells and the smooth muscle cells of the unparied arteries of hepatpcellular carcinoma specimens., Caveolin-1 inhibits the growth of human laryngeal squamous cell carcinoma HEp2 cell line. CAV1 interacts with EGFR and inhibits phosphorylation of EGFR and Erk1/2., PCB77 induces eNOS phosphorylation in endothelial cells through a Src/PI3K/Akt-dependent mechanism, regulated by functional caveolin-1., p53 is an indispensable component of cellular signaling system which is regulated by caveolin-1 expression, involving Akt activation and increase in cyclin D1, thereby promoting proliferation of breast cancer cells., Caveolin-1, specifically localized in cholesterol-enriched lipid rafts, appears to regulate constitutive and agonist-stimulated cell surface levels of 5-HT7 receptors via a clathrin-independent mechanism., results show that there is a close association of AT(1), AT(2), and ERalpha with Cav-1 in human arterial smooth muscle cells in culture, caveolin-1(CAV1) was observed in most cells in myomas and in only few cells in controls; CAV1 was localized with oxytocin receptor and sex hormone binding globulin in myomas, caveolin-1 travels to late endosomes and is replaced by newly synthesized caveolin-1 at the plasma membrane, CBD1 but not CBD2 binds cells and forms large aggregates at the plasma membrane by colocalizing with cytofacial caveolin-1., Caveolin-1 interacts and cooperates with the transforming growth factor-beta type I receptor ALK1 in endothelial caveolae., The knockdown of caveolin-1 in endothelial cells decreases caveolin-2 phosphorylation at serine 23 and upregulation of serine 23 phosphorylation depends on caveolin-1-driven targeting to plasma membrane lipid rafts and caveolae., The Cx43/Cavs association occurs during exocytic transport, and they clearly indicate that caveolin regulates gap junctional intercellular communication., We observed that in the Glu/Asp and Asp/Asp mutant genotypes, the amount of NOS3 associated with Cav-1 was significantly lower., low caveolin-1 levels in fibrotic lungs in scleroderma cause their overexpression of collagen, tenascin-C, and alpha actin, CAV1 as a new Berardinelli-Seip congenital lipodystrophy (BSCL)-related gene and support a critical role for caveolins in human adipocyte function., Very rare CAV1 frameshift mutations appear to be associated with atypical lipodystrophy and hypertriglyceridemia., AnxA6 interferes with caveolin transport through the inhibition of cPLA(2)., Interactions of acetylcholinesterase with caveolin-1 and subsequently with cytochrome c appear to be indispensable for apoptosome formation in a colon cancer cell line., an association between cav-1 expression and neoangiogenesis in meningiomas, Alteration of store-operated Ca(2+) entry by caveolin-1 expression changes could be one of the mechanisms contributing to the progression of breast cancer., caveolin-1 plays a tumor-promoting role in advanced-stage cancer. (review], a novel and unexpected pattern of Cav-1 expression in human skeletal muscle suggests a role for Cav-1 in terminal differentiation processes, Caveolin mediates rapid glucocorticoid effects and couples glucocorticoid action to the antiproliferative program., Androgen dependent prostate growth in benign prostate hyperplasia may be linked to the interaction of androgen binding protein and oxytocin receptor, associated with caveolin 1, focal adhesion kinase mediates caveolin-1 up-regulation during epithelial to mesenchymal transition, Downregulation of CAV1 is associated with primary prostate carcinoma, Cav-1 increases the basal and TGF-beta1-induced expression of type I procollagen by regulating two opposite signaling pathways, caveolin-1 may play an important role in the progression of transitional cell carcinoma of the upper urinary tract, This is the first evidence of increased nuclear and cytoplasmic localization of caveolin 1 during establishment of H(2)O(2)-induced premature senescence., Wild-type APC regulates CAV1 expression in human colon adenocarcinoma cell lines via FOXO1a and C-myc., Human breast cancer-associated fibroblasts show CAV1 down-regulation and RB tumor suppressor functional inactivation., Growth and proliferation related Akt and Erk1/2 pathways were inhibited after caveolin-1 down-regulation., Concluded that IL-6/sIL-6R enhances cathepsin B and L production via IL-6/sIL-6R-mediated Cav-1-JNK-AP-1 pathway in human gingival fibroblasts., We report a novel polymorphic purine complex stretching approximately 150 bp of genomic DNA at the 1.5 kb upstream region of the human CAV1 gene, alleles and genotypes of which are associated with sporadic late-onset Alzheimer's disease., the relationships between Cav-1 abundance, atherosclerotic plaque characteristics and clinical manisfestations of atherosclerotic disease., These data indicate that caveolin-1 specifies filamin A as a novel target for Akt-mediated filamin A Ser-2152 phosphorylation thus mediating the effects of caveolin-1 on IGF-I-induced cancer cell migration., These findings suggest that FASN and Cav-1 physically and functionally interact in PCa cells., Caveolin-1-dependent infectious entry of human papillomavirus type 31 in human keratinocytes proceeds to the endosomal pathway for pH-dependent uncoating, Caveolin-1 may provide an effective target to protect against human immunodeficiency virus-1 (HIV-1) protein Tat-induced brain microvascular endothelial cell dysfunction and disruption of the blood-brain barrier in HIV-1-infected patients., There is a role for caveolin-1 in degenerative rather than age-induced changes in the nucleus pulposus. A positive correlation was identified between gene expression of caveolin-1 and p16INK4a (biomarker of cellular senescence)., A new subtype of congenital generalized lipodystrophy is not associated with the CAV1 gene., Caveolin 1 appears to participate in the pathogenesis of tissue fibrosis in systemic sclerosis., irradiation triggered caveolin-1 dependent Receptor, Epidermal Growth Factor internalization into caveolae., caveolin-1 is expressed in cardiac myocytes, localized to both caveolae and non-caveolar domains in the plasma membrane, Co-expression of fatty acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma., variations of caveolin-1 expression may have an important role in the progression of human breast lobular cancer, a feedback loop between Rho/ROCK, Src, and phosphorylated Cav1 in tumor cell protrusions, identifying a novel function for Cav1 in tumor metastasis that may contribute to the poor prognosis of some Cav1-expressing tumors., Data indicate that HERG channels interact with caveolin-1 and are negatively regulated by this interaction., Absence of significant correlations between cav-1 expression and other pathological parameters, such as the stage of disease or the patients overall survival, indicates that the role of cav-1 in GC is neither stage-specific nor related to prognosis., Caveolin-1 plays a dual role in the fibronectin assembly regulated by uPAR signaling., Findings suggest that hOAT4 and caveolin-1 share a cellular expression in the plasma membrane and caveolin-1 up-regulates the organic anionic compound uptake by hOAT4 under the normal physiological condition., The phenotypic changes observed after caveolin-1 modulation were mediated by alpha(5)beta(1) integrins., These results reveal a new mechanism by which caveolin-1 negatively regulates TRAIL-induced apoptosis in human hepatocarcinoma cells., In head and neck squamous cell carcinoma, cav-1 may play an inhibitory role in tumorigenesis and lung metastasis through regulating integrin beta1- and Src-mediated cell-cell and cell-matrix interactions., Caveolin-1 is the membrane protein that forms part of the caveolae.The main functions of caveolae are transcytosis of both large and small molecules across cell membrane., Caveolin-1 was upregulated and beta-catenin was recruited to the plasma membrane when xCT was deficient, which were followed by the inhibition of beta-catenin transcriptional activity., Caveolin-1 expression is a distinct feature of chronic rejection-induced transplant capillaropathy., Reviews recent studies in adipocytes, the specialized cell type for fatty acid storage, which suggest a role for caveolins in the formation, maintenance or mobilization of lipid droplet stores., Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells., hepaCAM is partially localized in the lipid rafts/caveolae and interacts with Cav-1 through its first immunoglobulin domain., The data suggested that autophagy played a key role in Cd2+ induced endothelial dysfunction; integrin beta4, caveolin-1 and PC-PLC might be the targets of Cd2+ in vascular endothelial cells., GTPCH I is targeted to caveolae microdomains in vascular endothelial cells, and tetrahydrobiopterin production occurs in proximity to endothelial NO synthase. The regulation of GTPCH I activity involves the caveolar coat protein, caveolin-1., In prostate cancer cells in culture, delta-catenin was co-localized with caveolin-1 and CD59, suggesting its potential excretion into extracellular milieu through exosome/prostasome associated pathways., These data suggest that flotillin-1 regulates caveolin-1 level by preventing its lysosomal degradation in intestinal epithelial cells., caveolin-1 is essential in the down-regulation of MT1-MMP activity by promoting internalization from the cell surface, Data show that Cav-1 expression in tumor tissues was correlated with both the Ki-67 and p53 expression., Cav-1, increased after the 1,500 m swim trial in vastus lateralis ., CAV1 deficient mammary stromal fiboblasts are able to undergo endothelial-like transdifferentiation, and are predictive of poor outcome in breast cancer., By reducing COX-2 expression, caveolin-1 interrupts a feedback amplification loop involving PGE(2)-induced signaling events linked to beta-catenin/Tcf/Lef-dependent transcription of tumor survival genes including cox-2 itself and survivin., These data demonstrate that IGF-IR/integrin beta1 cross talk is followed by integrin beta1 lipid raft compartmentalization and that Cav-1 is required for this process., Akt-mediated transactivation of the S1P1 receptor in caveolin-enriched microdomains regulates endothelial barrier enhancement by oxidized phospholipids., This work defines a novel role for caveolin-1 with implications for the clinical course of breast cancer and identifies caveolin-1 as a potential drug target for the treatment of early oestrogen-dependent breast cancers, Immunostaining of Cav-1 can be used as a first step to stratify human breast cancer patients and to predict the presence of Cav-1 mutations., These results indicate that lipid rafts/caveolae participate in UT-A1 membrane regulation and this effect is mediated via a direct interaction of caveolin-1 with UT-A1., Exotest for CD63+ plasma exosomes had limited sensitivity but the Exotest for detection of caveolin-1+ plasma exosomes showed a higher sensitivity. Caveolin-1+ plasma exosomes were significantly increased with respect to CD63+ exosomes in patients group, Data show that efficient initiation of innate immunity to P. aeruginosa requires formation of an epithelial "internalization platform" involving both caveolin-1 and functional, laterally mobile CFTR., Cav-1(P132L) mutation is associated with metastasis in breast cancer., Cav-1 functions as a tumor suppressor in the stromal microenvironment., stromal caveolin-1 expression may be a potential therapeutic target and a valuable prognostic indicator of breast cancer progression., caveolin-1 may play an important role in the progression of hepatocellular carcinoma and angiogenesis., findings elucidate novel predisposing haplotypes at the CAV1 gene purine complex, and confirm the role of this region in the etiopathophysiology of late-onset Alzheimer disease, Caveolin-1 and caveolae play a paradoxical role in regulating VEGF-induced ERK2/1 activation and in vitro angiogenesis, Increased caveolin 1 is associated with metastatic lymph node sites in non-small-cell lung cancer., Caveolin-1 overexpression in the MCF-7 breast cancer cell line modulates EGFR activation levels and EGF-induced EGFR signalling., loss of caveolin-1 leads to hyperactive eNOS and subsequent tyrosine nitration-dependent impairment of PKG activity, which results in pulmonary hypertension., HPV16 infection is dependent on caveolin-1 after clathrin-mediated endocytosis., results revealed that the interaction between IFITM1 and CAV-1 could enhance the inhibitory effect of CAV-1 on ERK activation, Wild-type Cav-1, but not mutated Cav-1Y14A, increased tumorigenicity as indicated by enhanced proliferation, migration, invasion and capacity of forming foci in semisolid medium. Accordingly, Cav-1 silencing inhibited melanoma cell growth., loss of stromal Cav-1 is predictive of elevated levels of epithelial Cav-1 and epithelial Akt-activation and is associated with advanced prostate cancer., Serum cav-1 levels were higher in prostate cancer patients than in control men without prostate cancer, and the preoperative serum cav-1 concentration had prognostic potential in men undergoing radical prostatectomy[review], Upregulation of caveolin-1 expression is associated with nasopharyngeal carcinoma., Data imply that targeting CAV1 and/or PKCalpha may allow the development of new molecular therapeutic strategies to improve the treatment outcome for patients with ESFT., Cav-1 is a novel immunohistochemical marker for the differentiation of epithelioid mesothelioma from lung adenocarcinoma., Cav-1 immunoreactivity in lung carcinoma is histotype-dependent and acquired de novo in brain metastases, suggesting a site-specific phenotypic shift in secondary lesions., A potential binding site for caveolin-1 is present in the platelet-activating factor receptor (PAFR) sequence; many downstream signaling components of PAFR activation preferentially localize in caveolae., Data show that caveolin-1 and E-cadherin closely associated at cell borders and in internalized structures upon stimulation with EGF., Data show low or moderate methylation was found in seven selected genes BAD, BBC3, CAV1, CDK2AP1, NPM1, PRKCDBP and THEM4., These findings indicate a novel pathway for nitric oxide regulation of caveolin-1, which could be a key mechanism of anoikis resistance in tumor cells., caveolin-1 is not useful as diagnostic marker to differentiate grade II astrocytomas from oligodendrogliomas., caveolin-1 in hepatic cells increases oxidized LDL uptake and preserves the expression of lipoprotein receptors CD36 and SR-BI, might increase small cell lung cancer metastasis potential through the interaction with E-cadherin and MMP-3 genes, GM3 synthase overexpression results in reduced cell motility and in caveolin-1 upregulation in human ovarian carcinoma cells, Deletion of cav-1 protects hyperoxia-induced apoptosis via modulation of survivin expression., a combination of COX-2 and HMG-R inhibitors synergistically inhibits caveolin-1 and its associated signaling pathways, Data show that Nox2 and IL-1R1 localize to plasma membrane lipid rafts in the unstimulated state and that IL-1beta signals caveolin-1-dependent endocytosis of both proteins into the redoxosome., The relationship between caveolin-1 and apoptosis of lens epithelial cell under high glucose, was investigated., Caveolin 1 expression inhibits TrxR1-mediated cell transformation., Our data highlight the CAV1 upstream purine complex as a novel susceptibility genomic locus in the pathophysiology of MS. The region has been conserved across species, including mouse, guinea pig, rhesus macaque, and human., that HBV requires a Cav-1-mediated entry pathway to initiate productive infection in HepaRG cells, Cav-1 is an essential regulator of MT1-MMP function and invadopodia-mediated breast cancer cell invasion, Data show that the activities of EGFR-MAPK signal pathway were inhibited significantly by overexpression of cav1., Results suggest that activation of TRPC1-SOC by STIM1 mediates release of the channel from caveolin-1., Disruption of the caveolin-binding site interferes with the cav-1/maxi-K channel interaction, and lack of the cav-1/maxi-K channel interaction in MSMCs attenuates the total K+ channel current of the cell., RNAi knockdown of Cav-1 increased COX-2 protein level and decreased ubiquitinated COX-2 accumulation., Caveolin-deficient adipocytes can form only small lipid droplets, suggesting that the caveolin-lipid droplet pool might be involved in lipid droplet size regulation., Over-expression of caveolin-1 inhibits the growth and invasion of pancreatic carcinoma cells in vitro., could inhibit pancreatic carcinoma cell invasion, at least in part, probably through Erk-MMP signal pathway, Functional assays demonstrated enhanced early proliferation by CAV1 expression in TK6 cells after irradiation with clinically relevant doses supporting the role of CAV1 as a prosurvival factor., Matrix invasion and cell migration as well as expression of matrix metalloproteases were attenuated following caveolin-1 RNAi-mediated knockdown or overexpression of Y14F and P132L mutants, demonstrating dominant-negative activity of these mutants., caveolin-1 silencing induces concomitant decrease of TRPC1 expression and reduces oxLDL-induced apoptosis of VSMC, We found modest evidence for an association with a variant in the cav-1 gene and risk of overall prostate cancer and aggressive prostate cancer, Decreased Cav-1 expression in fibrotic diseases likely leads to increased deposition of IGFBP-5 in the extracellular matrix., Among kidney transplant donors, the CAV1 rs4730751 SNP was significantly associated with allograft failure in 2 independent cohorts, angiogenic growth factors downregulated IL-1beta-induced chondrocyte ageing and overexpression of caveolin-1 in human chondrocytes, The authors examine the interaction of cellular Cav-1 and HIV gp41 within the lipid rafts and show that Cav-1 modulates Env-induced bystander apoptosis through interactions with gp41 in SupT1 cells and CD4(+) T lymphocytes., Data demonstrate that caveolin-1 expression is a determinant of membrane PTEN levels and show that PTEN interacts with caveolin-1 via its caveolin-1-binding sequence., down-regulation of caveolin-1 protein expression leads to deregulate estrogen receptor alpha (ERalpha) signaling and consequently early transformation in mammary epithelia, These data demonstrate a new function for PTRF/cavin-1, a new functional interaction between caveolin-1 and Rab8 and that actomyosin interactions can induce tension on caveolin-1-containing membranes., Caveolin-1 regulates BeWo cell differentiation and fusion, possibly through a mechanism involving modulation of Akt activity., Messenger RNA and protein levels of Cav1 were increased in AM with silenced CFTR, QDs-IHC could accurately detect protein location in tongue mucosa. An increased expression of Cav-1 in the stepwise carcinogenesis from NTM, HTM, TPL to PTSCC suggested that Cav-1 might be an oncogene in the development of tongue squamous cell carcinoma., These results raise doubt about the presence of the caveolin-1 P132L mutation in breast cancer and other cancer types, and thus further studies are warranted, Overexpression of Cav1 accelerated internalization of mature hERG channels in 0 mM K(+)(o), whereas knockdown of Cav1 impeded this process., These results suggest that HIV infection enhances the expression of Cav-1 mediated by HIV Tat, which subsequently causes virus reduction, suggesting that Cav-1 may contribute to persistent infection in macrophages., Interaction of caveolin-1 functionally regulates the activity of the vascular subtype of K(ATP) potassium channel Kir6.1 in rat aortic smooth muscle cells., SR-BI, CD36, and caveolin-1 contribute positively to cholesterol efflux in hepatic cells., TGF-beta(1) reduced caveolin-1 mRNA and protein expressions in a dose- and time-dependent manner in fetal lung fibroblasts., Cav-1 may play a critical role in sensing genotoxic stress and in orchestrating the response of cells to DNA damage, the single Pro residue in the membrane-inserting segment of caveolin-1 plays an important role in both the membrane topology and localization of the protein as well as its functions, Beta-Dystroglycan interaction with caveolin-1 in smooth muscle is required for receptor-mediated Ca2+ release., This review provides new insights concerning the modulation of vascular smooth muscle ATP-sensitive K+ channels (KATP) channel gating by CAV1 that may have important implications for the control of diameter and blood flow in health and disease., Positive expression of caveolin-1 in bladder transitional cell carcinoma can be regarded as a high risk factor of recurrence., Single Nucleotide Polymorphisms in CAV1 is associated with primary open-angle glaucoma., Caveolin-1 may regulate the expression of LOX-1 and ox-LDL uptake., Regulator of G-protein signaling RGS-14 may prevent higher calcium ion (Ca2+) into the cytoplasm by reducing Ca2+ influx through Cav1 channels., This study demonistrated in patient with sporadic vestibular schwannomas down-regulation of CAV1 at both the mRNA and protein levels., reactive oxygen species and caveolin-1 have roles in lung cancer cell migration and invasion, pCav-1 is a new substrate of TCPTP and that integrin alpha1beta1 acts as a negative regulator of Cav-1 phosphorylation by activating TCPTP., caveolin-1 could suppress TrkA-mediated pleiotypic effects by altering TrkA modification via functional interaction., Mutations in Caveolin-1 is associated with breast tumorigenesis., The CAV1 became detectable in late endosomes (LE) and lysosomes where it was degraded., Identify leptin mediated proatherogenic mechanism and a novel caveolin-1 dependent leptin feedback mechanism which may have implications for development of peripheral leptin resistance in the endothelium., These results highlight a crucial role for caveolin-1 in negative regulation of membrane microdomain mobility, thereby affecting endocytosis of bacteria-engaged integrins., the molecular mechanisms by which CAV1 carries out its key role in regulating ESFT metastasis involve matrix metalloproteinase production and activation as well as the control of the expression of SPARC, a known determinant of lung colonization., miR-133a is directly bound to CAV1 mRNA. Cancer cell migration and invasion were significantly inhibited in HNSCC cells transfected with si-CAV1. Therefore, CAV1 functions as an oncogene in HNSCC., We conclude that the gene encoding CAV-1 plays an important role in the promotion of mammary tumorigenesis in Kashmir., Caveolin-1 plays a key role as a negative regulator of anoikis through a reactive oxygen species-dependent mechanism in human lung carcinoma H460 cells., Findings suggest that Cav-1 and PTRF/Cavin could represent two relevant and distinct targets to modulate IGF-IR function., Cav-1 immunoreactivity in lung cancer is histotype-dependent, increased Cav-1 expression indicates the malignant progression and high invasion features of non-small cell lung carcinomas., study identifies a new function for caveolin-1 in controlling smooth muscle phenotype; this mechanism could contribute to allergic asthma., Cav-1 polymorphisms are associated with oral cancer., Findings indicated a reduction of caveolin- 1 expression in NSCLC and suggested that caveolin-1 as well as VEGF-C might be involved in lymph node metastasis of NSCLC., data and observations imply that a primary open angle glaucoma (POAG) risk allele at the 7q31 locus that contains the caveolin genes CAV1 and CAV2 is not strongly associated with glaucoma in an Iowa population, Caveolin-1 may participate in the pathogenesis of bladder pain syndrome/ interstitial cystitis, CaR and Cav-1 co-localize on the plasma membrane in HUVECs and CaR-induced Ca(2+) influx is down-regulated by binding with Cav-1., Dynamic movement of cav-1 is essential for physiological contractile response of colonic smooth muscle., secreted CAV1 may also contribute to the malignant properties of Ewing's sarcoma., Study provides evidence for the relationship of this variant of CAV1 and risk of prostate cancer which might merit further study as a genomic marker for early detection of prostate cancer., caveolin-1 overexpression is associated with hepatocellular cancer., In the presence of Cav-1, phosphorylation of IKKbeta, IKKalpha, IkappaBalpha, and NF-kappaB p65 is dramatically reduced, while HIV-1 viral gene expression is suppressed., Caveolin 1 inhibits transforming growth factor-beta1 activity via inhibition of Smad signaling by hypertrophic scar derived fibroblasts in vi, Melanoma cells show remarkable resistance to Cav-1 disassembly, together with persisting cell signal activity, being Src and Cav-1 crucial modulators of Rho GTPases., This review is focused on the role of caveolin-1 in several soft tissue and bone sarcomas and discusses the use of this protein as a potential diagnostic and prognostic marker and as a therapeutic target., This is the first study to show that CAV1 mRNA expression is significantly higher in renal cell cancer compared with normal renal tissue., GATA-6 acts as a transcriptional repressor of CAV1 gene expression in partial bladder outlet obstruction-induced bladder wall smooth muscle hypertrophy, identify and characterize the signaling pathways that are activated in Cav-1 negative tumor stroma using gene expression profiling, CAV2 mRNA and protein levels are reduced by both NFBD1 knockdown and knockout independently of IR and p53, the loss of stromal caveolin-1 is related to poor prognosis in invasive ductal carcinoma, high Cav-1 expression in tumor cells and lack of this expression in stromal cells could help identify a particular subgroup of breast cancer patients with potentially poor survival., Skeletal muscle telocytes (TCs) express c-kit, caveolin-1 and secrete VEGF. In culture, TCs (but not satellite cells) emerge from muscle explants and form networks suggesting a key role in muscle regeneration and repair, at least after trauma., IGF1R internalization and co-localization with clathrin and CAV1 upon ligand binding, as well as the status of the IGF1R pathway, cellular proliferation, and the apoptosis of interfered and inhibited Ewing's sarcoma, were analyzed., Variations in the CAV1 gene are associated with insulin resistance and hypertension., Six overlapping haplotypes of caveolin 1 gene purine complex are detected in multiple sclerosis and Alzheimer's disease patients., Cav1 cooperated with the endogenous Ras/MAPK inhibitor Dok1 to promote the ligand-dependent transcriptional activity of PPARgamma and to inhibit cell proliferation, This study showed that Toll-like receptor 4 (TLR4) and caveolin-1 are binding partners in chondrocytes; their expression is temporally regulated by fluid shear via the sequential up-regulation of microsomal PGE synthase-1 and L-PGDS., Stroma associated with human carcinomas and melanoma metastases is enriched in Cav1-expressing carcinoma-associated fibroblasts (CAFs)., These findings reveal novel aspects regarding role of Cav-1 in modulating oxidative stress induced by cisplatin., subjects who had GG/AT or GG/AA at Cav-1 G14713A/T29107A showed a decreased risk of bladder cancer compared to subjects with GG/TT, while those of any other combinations were of increased risk., Caveolin-1 plays an important role in airway inflammation by modulating the effect of specific cytokines on intracellular calcium[Ca(2+)]., Data show that F92A-Caveolin-1 and a mutant cell-permeable scaffolding domain peptide called Cavnoxin can increase basal NO release in eNOS-expressing cells., Data show that expression of VCP mutant proteins, or siRNA-mediated depletion of UBXD1 leads to a block of CAV1 transport at the limiting membrane of enlarged endosomes in cultured cells., our results indicate that ERK1/2, Akt, and cav-1 are involved in the regulatory mechanisms of PPAR-mediated protection against HIV-1-induced MMP-9 expression in brain endothelial cells, these data are consistent with the possibility that accumulation of truncated Dsg2 protein interferes with desmosome assembly and/or maintenance to disrupt cell-cell adhesion., alpha7 nicotinic acetylcholine receptor-mediated signaling through caveolin-1-enriched lipid rafts/caveolae is required for nicotine-enhanced Escherichia coli K1 invasion of human brain microvascular endothelial cells., The identified single nucleotide polymorphisms are associated with primary open-angle glaucoma in the Caucasian US population and that specific haplotypes located in the CAV1/CAV2 intergenic region are associated with the disease., Cx43 controls the tumor phenotype of glioblastoma U251 cells and in particular, invasion capacity, through its localization in lipid rafts containing CAV1., caveolin-1 controls alpha(5) beta(1) integrin expression through the TGF-beta/TGF-betaRI/Smad2 pathway in glioblastoma, This study does not corroborate the reported frequent occurrence of CAV1 gene mutations, including CAV1 (P132L), in primary human breast carcinomas., Caveolin-1 knockdown by small interfering RNA reduces H2O2-induced Shp-2 phosphorylation in rat primary astrocytes and in CRT-MG human astroglioma cells., Study reveals an important role for cav-1 as a negative regulator of MMP-1 gene expression via inhibition of Erk1/2/Ets1 signaling in dermal fibroblasts., a role for gangliosides in regulating tumor cell motility by affecting the function of a signaling complex organized by caveolin-1, The results suggest that the region of caveolin-1 between amino acids 62 and 100 is an oligomerization domain as well as an attachment site for ABCA1 interaction that regulates HDL-mediated cholesterol efflux., The association of the potential risk haplotype agrees well with a role of CAV1 genotype in breast cancer risk and the association with tumor progression needs further investigation., The aim of this study was to evaluate the association between nasopharyngeal carcinoma susceptibility and Cav-1 genotypes., Arterial remodeling was associated with number of G alleles of CAV-1 polymorphism, GG homozygotes displaying intimal-media thickness and carotid cross-sectional area that were, respectively, 16% and 21% higher than those in patients without risk allele, sensitivity of non-small-cell lung cancer cells to metformin was dependent on Cav-1 expression, Cav-1 functions as a crucial modulator of epithelial-mesenchymal transition and cell differentiation in pancreatic cancer., Loss of stromal caveolin-1 is associated with early tumor recurrence., Caveolin-1 overexpression is associated with hepatocellular carcinoma tumourigenesis and metastasis., loss of CAV1 mRNA expression may play a role in prostate cancer progression., The interaction of LC3B and Fas pathways requires cav-1., SorLA and caveolin-1 directly or indirectly interact in glia and share subcellular distribution patterns., Phosphorylation of Tyrosine 14 in CAV-1 and transcriptional regulation of CAV-1 expression may have a role in glaucomatous alterations in trabecular meshwork cells of patients with primary open angle glaucoma., High expression of stromal Cav-1 correlates with longer survival in malignant melanoma metastases, and high expression of Cav-1 in melanoma cells correlates with longer survival in primary malignant melanoma., Membrane binding CAV1 key fragments are involved in multiple critical functions that include protein recognition, oligomerization, and cholesterol binding consistent with the role for CAV1 scaffolding domain., Over expression of caveolin-1 in the tumour cell cytoplasm predicts a poor prognosis of patients with clear cell RCC., Insignificant differences in Cav-1 between the sera of patients and controls (5.69 in the cancer group vs. 5.42 ng/ml in the control group)., Findings defined Cav-1 as an important downstream oncogenic target of FoxM1, suggesting that dysregulated signaling of this novel FoxM1-Cav-1 pathway promotes pancreatic cancer development and progression., Higher Cav1 expression correlated with the advanced pathological stage and shorter survival rates in lung adenocarcinoma patients., Alterations of TES mRNA level may predict the location of metastasis. CAV1 possibly affect the cancer cell invasion, Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1., Stromal caveolin-1 expression were more frequent in anaplastic carcinoma and diffuse sclerosing variant of papillary carcinoma compared to conventional papillary thyroid carcinoma., caveolin-1 normally traffics to and from the cytoplasmic surface of lysosomes during intracellular cholesterol trafficking., The transmembrane domain of caveolin-1 exhibits a helix-break-helix structure., Cav-1 is an important regulator of store-operated Ca(2+) entry in human airway smooth muscle by influencing plasma membrane sarcoplasmic reticulum interactions., Systemic sclerosis fibroblasts with constitutive Smad1 phosphorylation have elevated cav-1 expression., our results indicate a novel role of Cav-1 in anoikis regulation through Mcl-1 interaction and stabilization, A novel role of Cav-1 protein is the suppression of cellular oxidative stress induced by hydrogen peroxide in lung carcinoma., These data support that C. neoformans internalization into HBMEC is a lipid raft/caveolae-dependent endocytic process where the actin cytoskeleton is involved, and the Cav1 plays an essential role in C. neoformans traversal of the blood-brain barrier., activation of eNOS promotes Src-dependent Cav-1-Tyr-14 phosphorylation and eNOS/Cav-1 binding, that is, eNOS feedback inhibition, This review presents the current understanding of their function and the involvement of caveolin-1 in breast cancer pathogenesis. [review], We hypothesise that it is the activity of Src that drives the relationship with Cav-1 and RhoGD12 expression in transition cell carcinoma of the bladder, WNT6 and Cav1 are upregulated by chemotherapeutics and enhance the resistance of GC cells to anthracycline drugs, results suggest expression of Cav-1 in the tumour cells, rather than in the stromal tissue surrounding the tumour, may promote cervical squamous cell carcinoma cell proliferation, and correlates with high-risk HPV infection, nestin and caveolin-1 could have a role in GISTs, together with CD117 and CD34, These results add CAV1 to the list of systemic sclerosis susceptibility genes and provide further evidence for the contribution of this pathway in the fibrotic process that characterises pathogenesis., CAV1 is a direct transcriptional target of oxygen-labile hypoxia-inducible factor 1 and 2 that accentuates the formation of caveolae, leading to increased dimerization of EGF receptor., novel roles for CAV1 variants in cell death; wtCAV1 promotes cell death, whereas CAV1beta promotes cell survival by preventing inactivation of BCL2 and BCLxL via JNK in paclitaxel-mediated apoptosis., Actin, microtubules and Abl tyrosine kinases regulate Cav1 inward trafficking., Data suggest that Cav1 is down-regulated in 95% of tumor specimens from patients with Barrett adenocarcinoma; strong cytoplasmic expression of Cav1 correlates with poor disease-free survival in small subgroup of patients., A frameshift mutation in caveolin-1 (CAV1)is identified, which encodes a membrane protein of caveolae abundant in the endothelium and other cells of the lung., Promoter hypermethylation and loss of expression of the CAV-1 gene is associated with breast cancer., point mutations at position 132 of Cav1(62-178) revealed that no other hydrophobic amino acid can preserve the monomeric state of Cav1(62-178), indicating that proline 132 is critical in supporting proper caveolin-1 behavior., Gal3 and Cav1 therefore function synergistically to promote focal adhesion signalling, migration and progression of differentiated thyroid cancer., Caveolin-1 and dynamin-2 are essential for removal of the complement C5b-9 complex via endocytosis., Cav-1 inhibits cellular antioxidant capacity through direct interaction with Nrf2 and subsequent suppression of its activity, Perturbation of Ca(V)1.1 negative regulation of RyR1 leak identifies a unique mechanism that can sensitize muscle cells to malignant hypothermia triggers., CAV-1 affected cell growth of lung cancer NCI-H446 cell through the interactions with p-ERK1/2, estrogen receptor and progestin receptor, The research reports a novel role for calveolin-1 in tumour-induced immunosuppression during the progression of chronic lymphocytic leukaemia., Caveolin1 acts upon EGF endosomes internalized via the Clathrin-pathway and functions at the transition from early to late endosomes., confirmed that depletion of CAV1 rendered anoikis-resistant H_AR2 cells sensitive to anoikis, the human CAV1 upstream purine complex modifies gene expression, Overexpression of caveolin 1 in HM-7 cells down-regulate proliferation, viability, wound closure, adhesion to laminin, invasion, and development of filopodial and lamellipodial structures in a dose-dependent manner., complex formation between the DLC1 START domain and CAV-1 contributes to DLC1 tumor suppression via a RhoGAP-independent mechanism, and suggest that DLC1 inactivation probably contributes to cancer progression., Data show that elevated CAV1 upregulates glucose uptake and ATP production through HMGA1-mediated GLUT3 transcription, suggesting that CAV1 may render tumor cells growth advantages by enhancing aerobic glycolysis., In healthy humans, increases in leptin, as seen with modest weight gain, may increase caveolin-1 expression in adipose tissue; increased caveolin-1 expression in turn impairs leptin signaling., caveolin-1 acts as an anti-apoptotic protein in colon cancer cells by binding to Ku70 and inhibiting Bax-dependent cell death., Since hypoacetylated p65 has been shown to inhibit transcription, the authors conclude that caveolin-1 inhibits HIV-1 transcription through a NF-kappaB-dependent mechanism., Caveolin-1 promotes monocyte to macrophage differentiation through the regulation of EGR-1 transcriptional activity, suggesting that phagocytic caveolin-1 may be critical for atherogenesis., Caveolin-1 suppresses the growth and differentiation of undifferentiated mesenchymal stem cells, and upon cell differentiation caveolin-1 expression is upregulated to stabilize the cell phenotype and reduce cell plasticity and renewal potential., The correlation observed between Caveolin-1 and downstream signaling molecule expression may be an important mechanism of arsenic-induced urothelial carcinogenesis., Differential depot-specific expressions of caveolin-1 are present in human subcutaneous and omental adipose tissues. A low expression of caveolin-1 in omental adipose tissue may contribute to the pathogenesis of obesity and insulin resistance., The reduced expression of caveolin-1 in lung tissues of idiopathic pulmonary fibrosis might be related to disease development and progression., Transfected HBx significantly suppressed caveolin-1 promoter activity., Data suggest that down-regulation of CAV1 suppresses proliferation of lung carcinoma cells and may promote metastasis of lung tumors., Cav-1 is the key regulator of anchorage independent growth and anoikis resistance in lung carcinoma cells., Loss of caveolin-1 from bronchial epithelial cells and monocytes in human subjects with asthma., CAV1 and -2 potentiate epsilon-toxin induced cytotoxicity by promoting toxin oligomerization, The interplay of Cav-1 with Nef and cholesterol subsequently counters Nef induced impairment of cholesterol efflux by apoA-l., There is a divergent control of Cav-1 expression as evidenced in non-cancerous Li-Fraumeni syndrome and some aggressive human cancer cell lines., This study demonstrates that caveolin-1 is strongly expressed within caveolae-like structures and associated vesicles within liver sinusoidal endothelial cells of the hepatitis C-related cirrhotic liver., CpG island shore methylation regulates caveolin-1 expression in breast cancer., positive fibroblastic LC3B correlates with lower invasion, and low expression of fibroblastic Cav-1 is a novel predictor of poor GC prognosis., The level of caveolin-1 expression seems to be related to the clinical severity of psoriasis, and may play a role in the abnormal keratinocyte hyperplasia., In sarcoma cells Caveolin-1 expression is associated with protection against doxorubicin-induced cell death. (Review), Loss of Cav1 affects several characteristics associated with aggressive human skin tumors and this protein may be an important modulator of tumor growth and invasion in cutaneous squamous cell carcinoma., Expression levels of ERBB2, caveolin-1 and DNA-PKcs were increased., Caveolin-1 is induced in colon cancer cells in response to K-RAS activating mutations. K-RAS regulates both caveolin-1 expression and other factors affecting caveolin-1 functions in colon cancer-derived cell migration., These data provide strong evidence that octarepeats of PrP are critical for the interaction between PrP and Cav-1., Exo70 is involved in caveolin-1 recycling to the plasma membrane during re-adhesion of the cells to the substratum., results show that Cav-1 interacts with LRP6 to generate an integrated signaling module that leads to the activation of IGF-IR/IR and results in stimulation of Akt-mTORC1 signaling and aerobic glycolysis in prostate cancer, Data indicate that endosomal trafficking of CAV1 depends on ubiquitination of the N-terminal region and the subsequent recruitment of VCP-UBXD1., these results suggest that caveolin-1 is a novel physiological activator of PP5., Caveolin-1 regulates Rac1 activation and rat pulmonary microvascular endothelial hyperpermeability induced by TNF-alpha., Our findings suggest that CAV-1 may play a critical role in Hepatocellular carcinoma carcinogenesis, Although the exact roles of Cav-1 and IGF-IR in human cancer continue to be a matter of some debate, there is a strong evidence for an association between Cav-1 and IGF-IR in cancer development.[review], Caveolin 1 expression is up-regulated in inflamed periodontal tissues compared to the healthy gingiva., stromal CAV1 expression is down-regulated, which leads to the release of a variety of molecules that either enhance the metastatic capacity of endometrial cells or contribute to adenomyosis-associated dysmenorrhea, The present study revealed the novel role of Cav-1 and underlying mechanism on tumor adhesion., the proper expression of CAV1 is important not only for maintaining the appropriate morphology and size of ECs but it might represent a prospective molecular target for studying key biological mechanisms such as senescence and tumorigenesis., CAV1 T29107A (rs7804372) polymorphism may influence susceptibility to prostate cancer., Loss of epithelial Cav-1 may promote malignant progression and low CAFs Cav-1 level herald worse outcome of GC patient., study investigated the expression of VEGFR-1, VEGFR-3 and caveolin-1 molecules in 183 colorectal cancer tissue specimens and explored their effect in both clinicopathological parameters and disease prognosis, FoxO3a (Forkhead Box O3a) deficiency protects Idiopathic Pulmonary Fibrosis (IPF) fibroblasts from type I polymerized collagen matrix-induced apoptosis via caveolin-1 (cav-1) and Fas., Caveolin-1 conveys a homeostatic antifibrotic function by regulating TGF-beta1 and its downstream signaling; regulating critical cellular processes involved in tissue repair; antagonizing cell proliferation.(Review), Cav-1-overexpressing U-87MG cells display reduced tumorigenicity in an ectopic xenograft mouse model, with marked hypoactivation of MAPK and PI3K/mTOR pathways., Expression of Cav1 is tightly correlated in both prostate tissues and cell lines and significantly higher in cancer vs. normal tissues., The A allele of CAV1 G14713A is risky, while the A allele of CAV1 T29107A is protective for the development of childhood leukemia., results demonstrate the counterregulatory heme oxygenase-1/CO pathway, which is critical in balancing and limiting the inflammatory response, is defective in cystic fibrosis macrophages through a CAV-1-dependent mechanism, exacerbating the cystic fibrosis macrophage response to lipopolysaccharide, Data indicate that caveolin-1 is a direct binding partner of nuclear factor-erythroid 2-related factor (Nrf2)., Increased plasma caveolin-1 levels are associated with progression of prostate cancer., ERK1/2 phosphorylation is under a negative influence by CAV1 during internalization of exosomes., Pilus phase variation switches gonococcal adherence to invasion by caveolin-1-dependent host cell signaling., apoE mediates the effects of leptin on vascular lesion formation by stabilizing cav-1-enriched cell membrane microdomains in smooth muscle cells, thus allowing NADPH oxidase assembly and ROS-mediated mitogenic signalling., Data indicate that AMP-dependent kinases (AMPKalpha1 and AMPKalpha2) inhibit caveolin-1 phosphorylation by stabilizing the interaction between c-Abl and Prdx-1., Loss of caveolin-1 in prostate cancer stroma correlates with reduced relapse-free survival and is functionally relevant to tumour progression., DNA from 4 HPV positive and 4 HPV negative fresh frozen primary HNSCC were subject to comprehensive genome-wide methylation profiling.Pathway analysis of 1168 methylated genes showed 8 signal transduction pathways (CAV1) of which 62% are hypermethylated., Caveolin-1 overexpression improved barrier function., Our findings did not correspond with previous positive results, suggesting that CAV1-CAV2 variants studied in the present study are not important risk factors for Normal Tension Glaucoma susceptibility., Variation in the donor apolipoprotein L1 (APOL1), caveolin 1 (CAV1), and multi-drug resistance 1 encoding P-glycoprotein genes (ABCB1) are all associated with graft survival after kidney transplantation. [Review], The tumor-promoting role of cavin-1 in pancreatic cancer was found to be largely dependent on caveolin-1., Loss of caveolin-1 promotes endothelial-mesenchymal transition during sepsis., downregulation of caveolin-1 can be significant as Fanconi anemia patients have an elevated predisposition to develop cancer, The presence of a CC genotype in Birmingham is associated with protection from adverse outcomes of immunosuppression treated AAV. Lack of replication in the European cohort may have resulted from low clinical event rates., Alterations in Cav-1 and MCT4 expression may mark a critical point in the progression from in situ to invasive breast cancer., caveolin-1 in advanced prostate cancer is present outside of caveolae, because of the lack of cavin-1 expression, In this review caveolin-1, the major structural protein of caveolae, is overexpressed in prostate cancer patients., EphA2-induced angiogenesis in ewing sarcoma cells works through bFGF production and is dependent on caveolin-1., We identified a nominally significant SNP (P < 0.05), rs4236601 in CAV1/CAV2, in primary open angle glaucoma., Down-regulation of stromal Cav-1 expression is associated with esophageal squamous cell carcinoma, This meta-analysis suggests that rs4236601[A] is associated with increased risk for POAG in Caucasian and Asian populations., An elevated risk of gastric cancer was observed in patients with H. pylori infection combined with the Cav-1 G14713A, but not T29107A genotypes., Cav-1 may be a cofactor in the interaction of Derlin-1 and N-glycosylated COX-2 and may facilitate Derlin-1- and p97 complex-mediated COX-2 ubiquitination, retrotranslocation, and degradation., The combined expression of Cav-1 and pERK serves as an independent biomarker signature with potential merit in renal cell carcinoma surveillance strategies., Glioblastoma-mediated suppression of tumor-associated myeloid cell function is mediated at least in part by CAV1, and importantly, that activity can be restored by suppressing CAV1., Clathrin and caveolin-1 have a role in docking of SMAD4 at the cell membrane., single nucleotide variation of caveolin-1 gene is associated with upper urothelial tract cancer., Altered expression of caveolin-1 in the thyroid epithelial and stromal compartments may be involved in the pathogenesis of papillary thyroid carcinoma., caveolin-1-enriched microdomains have a role in Gas6-induced tissue factor expression in endothelial cells, caveolin-1 is involved in the regulation of lipoprotein transcytosis across endothelial cells and in the regulation of vascular inflammation., These results demonstrate for the first time that adiponectin inhibits TNFalpha-induced inflammatory response via Cav1-mediated ceramidase recruitment and activation in an AdipoR1-dependent fashion., Phosphocaveolin-1 enforces tumor growth and chemoresistance in rhabdomyosarcoma., GLI1 may be attributed to Cav-1 up-regulation which plays an important role in GLI1-driven epithelial-mesenchymal transition phenotype in hepatocellular carcinoma., Cav-1 is an important anti-AF signaling mediator by conferring its anti-fibrotic effects in atrium, Caveolin-1 expression is decreased in samples of non-small cell lung cancer., CAV1/CAV2 SNPs were associated significantly with primary open-angle glaucoma overall, particularly among women., These findings indicate that CAV1 interacts with ABCG1 and regulates ABCG1-mediated cholesterol efflux., African Americans may be predisposed to systemic sclerosis-related interstitial lung disease due to low baseline caveolin-1 levels in their monocytes, potentially affecting signaling, migration, and fibrocyte differentiation., Breast cancer nodal metastasis correlates with tumour and lymph node methylation profiles of Caveolin-1 and CXCR4., Caveolin 1 knockdown inhibits the proliferation, migration and invasion of human breast cancer BT474 cells., Cav-1 plays a duplex role in tumorigenesis and tumor progression in non-small cell lung cancer, conclude that the GG genotype of CAV-1 is protective, associated with a decreased overall mortality, These results suggest a new model in which caveolin-1 might be involved in Salmonella entry via its interaction with SopE and Rac1, leading to enhanced membrane ruffling for phagocytosis into host cells., Caveolin-1 in lipid rafts interacts with dengue virus NS3 during polyprotein processing and replication in vascular endothelial cells., these data provide the first detailed analysis of Cav-1 binding to one of its most significant client proteins, eNOS., stimulates Rab5 activation, leading to increased Rac1 activity and cell migration, hSlo1c associates with Cav-1 in human brain microvascular endothelial cells. This association boosted Cav-1 transfer from the cell membrane to the cytoplasm. It is crucial for regulating the permeability of the blood-tumor barrier., Cav-1 could be a cellular defense protein against alcoholic hepatic injury through inhibiting reactive nitrogen species and regulating EGFR/STAT3/iNOS-signaling cascades., Cav-1 competitively interacts with the ATG12-ATG5 system to suppress the formation and function of the latter in lung epithelial cells., Cav-1 is implicated in the pathogenesis of asthma and chronic inflammatory respiratory diseases and influences inflammation, fibrosis, smooth muscle contractility, regulation of apoptosis,cell senescence,epithelial barrier function and homeostasis., Our findings suggested that CAV1 genotype may determine the individual susceptibility to gastric cancer, our results showed cav-1 expression in all odontogenic cysts and 58% of ameloblastomas., The present review summarizes the current knowledge and views on the regulatory role of CAV1 on the cholesterol homeostasis with emphasis on the association of CAV1 with ABCA1 and ABCG1. [review], Our findings suggest that Cav1 may play a critical role in the etiology of sarcopenia, and the A allele of Cav1 G14713A may serve as an early marker for detection of sarcopenia and severe sarcopenia., The expression of caveolin-1 was positively correlated with an advanced pathologic stage. Thus, caveolin-1 could act as a predictor of a poor prognosis in patients with large cell lung carcinoma, Data suggest that Src activates EGFR through the interaction of both Src-EGFR and Src-caveolin-1, and then antagonizes TRAIL-induced apoptosis in gastric cancer cells., CAV1 promoter hypermethylation is a frequent event in human esophageal carcinomas and is associated with early neoplastic progression in Barrett's esophagus., Human uterine leiomyomas in vitro express low levels of Cav-1 compared to normal myometrium, which may result from estrogen inhibition., Using gene manipulation strategies, authors reveal for the first time that Cav-1 plays an essential role in CSC regulation and aggressiveness of SWCNT-transformed cells partly through p53 dysregulation., The loss of stromal Cav-1 in pancreatic cancer was an independent prognostic indicator, thus suggesting that stromal Cav-1 may be an effective therapeutic target for patients with pancreatic cancer, the induction of EMT was found in Cav-1-knock down cells treated with NO, suggesting that EMT was through Cav-1-independent pathway., Data suggest that the role for caveolin-1 (CAV-1) in promoting bladder cancer metastasis presents CAV-1 and related pathways as potential therapeutic targets in invasive bladder cancer., In overfed human subjects, CAV1 protein expression was correlated with increased adipocyte size, but not with increased adipocyte number., Interactions of caveolin-1 scaffolding and intramembrane regions containing a CRAC motif with cholesterol in lipid bilayers., Data show that caveolin-1 is necessary for optimal KSR1-dependent ERK activation by growth factors and oncogenic Ras., Caveolin-1 is a positive regulator for E2-induced cell growth by promoting auptophagy and inhibiting apoptosis in BT474 cells., The role of caveolin-1 in mediating the chemoresistance of breast cancer stem cells via beta-catenin/ABCG2 regulation., CAV1 rs729949 was associated with increased risk of hepatocellular carcinoma., The SNP rs3807989 in CAV1 gene is not associated with AF in Chinese Han patients., we attempt to abridge the relationship between caveolin-1 and oral squamous cell carcinoma [review], reciprocal activating crosstalk between c-Met and CAV1 promoted oncogenic signaling of c-Met contributed to the initiation and progression of HCC., The role of CAV1 in hepatocellular carcinoma progression was explored in this study., we found that along with these factors, CAV1 acts in cohort in reducing cell migration and inducing apoptosis., CAV1 rs3807989 may contribute to a decreased atrial fibrillation risk in Chinese Han populations, The results showed that the G allele of the Cav-1 G14713A and the A allele of the Cav-1 T29107A are risky genetic factors for renal cell carcinoma susceptibility., Results suggest that CAV1 could function as a potent tumor suppressor in ARMS tumors. Inhibition of CAV1 function therefore, could contribute to aberrant cell proliferation, leading to ARMS development., Suggest that overexpressed SPP1, PAI and caveolin-1 were linked to carcinogenesis and progression, and thus they may serve as potential prognostic factors in oral squamous cell carcinoma., Low caveolin-1 expression is associated with gastric cancer., Cav-1 protein was up-regulated in response to the acquisition of anoikis resistance and the up-regulation of Cav-1 played an important role in regulation of several cancer cell behaviors., The findings suggest that large conductance Ca(2)-activated potassium (BKCa) channels is a critical target for suppression by caveolin-1 in suppressing proliferation and invasion of breast cancer cells., We further confirmed that miR-103/107 inhibited P-gp function in gastric cancer SGC7901/ADR cells. Finally, we verified that caveolin-1 (Cav-1), a critical component of lipid rafts, was a target of miR-103/107, In conclusion these data suggest that Streptococcus pneumoniae PspC-promoted uptake via the polymeric immunoglobulin receptor of epithelial cells is mediated by both clathrin and caveolin dependent pathway., The significant association of three common variants in TMCO1, ATOH7, and CAV1 with primary open angle, primary angle closure, and pseudoexfoliation glaucoma was found in Pakistani cohorts., The implication of the caveolin genes, CAV1/CAV2, as a common genetic factor influencing both IOP variations and POAG may provide new insights of the underlying mechanism leading to glaucoma and glaucomatous visual field loss., Cav1 ectopic expression reverses EMT in human peritoneal mesenchymal cell from peritoneal dialysis patients., The authors not only show that langerin and caveolin-1 co-localize at the cell membrane and in vesicles but that caveolin-1 mediated HIV-1 uptake is an intrinsic restriction mechanism present in human Langerhans cells that prevents HIV-1 infection., Data show that caveolin-1 (Cav-1) is up-regulated, but collagen I (COL I) is down-regulated, in chronologically-aged skin of human and mouse., cavin3 is recruited to the caveolae coat by cavin1 to interact with caveolin1 and regulate the duration time of caveolae at the plasma membrane., caveolin-1 may at least in part determine gene transfer efficiency and cytotoxicity of polyethyleneimine in mammalian cell lines., The loss of stromal CAV-1 expression in colorectal carcinoma was associated with poor prognosis., Caveolin-1 accumulation in the tongue cancer tumor microenvironment is significantly associated with poor prognosis, The lipid raft scaffolding protein caveolin-1 interacts with the STIM1-Orai1 complex to increase channel activity., Selective targeting of this SMAD-independent, p38-MAPK/Cav-1-dependent pathway is likely to be effective in the treatment of pathological conditions characterized by TGF-beta signaling and myofibroblast activation., Interaction of Cav1 with its receptor EGFR inhibits signaling and reduces cell proliferation, supporting a tumor suppressor function for Cav1., the AKT/miR-199a-5p/CAV1 pathway is identified as a regulator of innate immunity, which is dysfunctional in cystic fibrosis macrophages contributing to lung hyper-inflammation., suggesting that N-SH2 domain of SHP-2 is responsible for the binding of caveolin-1 and contributes to the regulation of Src phosphorylation and activation following ROS-induced oxidative stress in brain astrocytes, placental expression reduced in pre-eclampsia, donor Cav1 genotype correlates with long-term pancreas graft function, Using in silico and in vitro analysis we show that Cavin-1 is expressed in myogenic Rhabdomyosarcoma tumors and human and primary mouse RMS cultures. Cavin-1 or Cav-1 knockdown led to impairment of cell proliferation and migration., The CAV1 expression was increased during colonocyte differentiation and mediated butyrate-induced differentiation and apoptosis of HT29 cells., disruption of cav-1 decreases basolateral K(+) channel activity and depolarizes the cell membrane potential in the DCT1 at least in part by suppressing the stimulatory effect of c-Src on Kcnj10, Interactions between ABCB1 and CAV1 with APOL1 may influence allograft failure for transplanted kidneys from African American donors., data suggest the potential for Cav-1 as a possible novel therapeutic target in NPC treatment, A novel chimeric aequorin fused with caveolin-1 reveals a sphingosine kinase 1-regulated Ca(2) microdomain in the caveolar compartment., these findings demonstrate that syntenin may act as an important positive regulator of TGF-b signaling by regulating caveolin-1-mediated internalization of TbRI; thus, providing a novel function for syntenin that is linked to cancer progression., study reports heterozygous de novo disease-causing mutations in CAV1 gene in 2 patients presenting with neonatal onset of generalized loss of subcutaneous fat but sparing the buttocks with additional distinctive phenotypic features; report extends the spectrum of disorders due to CAV1 mutations to include one subtype of lipodystrophy, the results of our genetic analysis do not support the involvement of CAV1 in morphea., downregulation of CAV1 and enhanced autophagy level were observed in human breast cancer cells and tissues., The data revealed a significant association between CAV1 variant rs3807989 and Atrial Fibrillation in the Chinese Han population, Under the regulation of Rab5, the fused vesicles are targeted to early endosomes and thus deliver the internalized TbetaRI to the caveolin-1 and EEA1 double-positive early endosomes (caveolin-1-positive early endosomes)., The minor allele G of rs17588172 in the CAV1-CAV2 locus is associated with decreased expression of CAV1 and CAV2 in some tissues, marginally with intraocular pressure elevation, and consequently with increased susceptibility to high-tension glaucoma., The results suggested that differential levels of P-glycoprotein, Caveolin-1 and Fatty acid synthase except CYP450 play a major role in acquired resistant phenotype in bladder cancer., Our study shows that elevated CAV1, observed in patients with endometrial cancer, is linked to enhanced malignancy of endometrial cancer cells, as evidenced by increased migration, invasion and anchorage-independent growth., In PC cell lines, disruption/depletion of caveolae/Cav-1 reduces proliferation, colony formation, and invasion., results indicate that the two SNPs (Cav-1 rs1049334 and ROCK1 rs35996865) and genotypes with a combination of 2-4 risk alleles were associated with the risk of ccRCC., study suggest that CAV1 may not act as a potential biomarker of uterine malignant mesenchymal tumors, Study demonstrates the importance of CAV1 interaction with the cytoskeleton, which includes shape change and adhesion. Cav1 modulates the focal adhesion complex through vinculin and participates in the tension forces during adhesion and clot retraction., Cavin-1 and cavin-2 are strongly expressed within caveolae-like structures within liver sinusoidal endothelial cells of the hepatitis C-related cirrhotic liver and cavin-1 would play a critical role in regulating aspects of caveolin-1., higher protein expression in tumor is associated with both improved response rate and overall survival in advanced non-small-cell lung cancer, CAV1 expression was positively related to IGF-1R expression in human hepatocellular carcinoma tissues; CAV1 confers resistance of hepatoma cells to anoikis by activating IGF-1 pathway., These results suggest that HIV interferes with cholesterol efflux by high-density lipoprotein in human aortic endothelial cells through the disruption of Cav-1s' cellular distribution., Caveolin-1 protein may be an effective predictor for determining the outcome of T-DM1 treatment in breast cancer patients., Microarray data of the expression level of key genes reveals that CAV1 is critical for cervical cancer invasion and metastasis., High CAV1 expression is associated with colon tumors., Our findings demonstrated a link between Caveolin-1 expression and the aggressiveness of ovarian cancer, Suggest that IFITM1 promotes the aggressiveness of colorectal cancer cells via caveolin-1 signaling., Loss of PTEN in melanoma increases CAV1-mediated dissociation of beta-catenin from membranous E-cadherin, which may promote senescence bypass and metastasis., Data show that caveolin 1 expression in brain metastasis was associated with poor prognosis and an increased risk of death., Cholesterol and CAV-1 modulate the function and dynamics of the slow channel congenital myasthenia syndrome alphaC418W nicotinic acetylcholine receptor mutation., LPS-induced Cav-1 phosphorylation in pulmonary microvascular endothelial cells may lead to an increase in transcellular permeability prior to an increase in paracellular permeability in a Src-dependent manner., Loss of Cav1 in head and neck squamous cell carcinoma enables tumor cells to undergo epithelial-mesenchymal transition., The prevalent CAV1 gene variant rs926198 is associated with metabolic syndrome in separate Caucasian and Hispanic cohorts, knockdown of Cav-1 was also able to significantly downregulate the protein expression level of Notch-1, p-Akt and p-NF-kappaB p65 in cisplatin-resistant ovarian cancer cells., serum Cav1 might be a novel biomarker in the diagnosis of IPAH with fare sensitivity and good specificity. Second, Cav1 might be used to make differential diagnosis between COPD-PH and IPAH group, CAV-1 and -2 have roles in progression of prostate neoplasms, CAV1 has a role in the tumor microenvironment of mature T-cell malignancies, Mutant CAV1 forms caveolae structures similar to wild-type but leads to increases in nitric oxide bioavailability., hypothesize that focal adhesion signaling pathways such as PI3K/Akt signaling may be negatively regulated by Cav-1 during mesenchymal stem cell osteogenesis, This study reports an unanticipated function of ROR1 as a scaffold of cavin-1 and caveolin-1, two essential structural components of caveolae., data provides novel insight into the regulation of CAV1 gene by histone H3 modifications and enhance the amplitude of the cancer epigenome, Ankrd13 proteins cooperate with VCP to regulate the lysosomal trafficking of ubiquitinated Cav-1., Cav-1 has a novel role in TCR/Lck spatial distribution upon TCR triggering, which controls T-cell fate toward a regulatory phenotype, Data show that loss of epithelial membrane protein 2 (EMP2) is involved in sphingosylphosphorylcholine (SPC)-induced phosphorylation of keratin 8 (K8) via ubiquitination of protein phosphatase 2 (PP2A) through alpha4 phosphoprotein by caveolin-1 (cav-1)., Hypoxic down-regulation of constitutive endocytosis is HIF-independent, and involves caveolin-1-mediated inhibition of dynamin-dependent, membrane raft endocytosis.,
OFFICIAL_GENE_SYMBOL CAV1,
OMIM_DISEASE Partial lipodystrophy, congenital cataracts, and neurodegeneration syndrome, Lipodystrophy, congenital generalized, type 3, Pulmonary hypertension, primary, 3,
SP_COMMENT disease:Defects in CAV1 are the cause of congenital generalized lipodystrophy type 3 (CGL3) [MIM:612526]; also called Berardinelli-Seip congenital lipodystrophy type 3 (BSCL3). Congenital generalized lipodystrophies are autosomal recessive disorders characterized by a near absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes., function:May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity., online information:Caveolin entry, PTM:The initiator methionine for isoform Beta is removed during or just after translation. The new N-terminal amino acid is then N-acetylated., similarity:Belongs to the caveolin family., subcellular location:Potential hairpin-like structure in the membrane. Membrane protein of caveolae., subunit:Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin. Interacts with rotavirus A NSP4., tissue specificity:In muscle and lung, less so in liver, brain and kidney.,