Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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phosphoinositide-3-kinase regulatory subunit 3(PIK3R3) phosphoinositide-3-kinase regulatory subunit 3(PIK3R3) Related Genes Homo sapiens
CHROMOSOME 1,
CYTOBAND 1p34.1,
ENSEMBL_GENE_ID ENSG00000117461, ENSG00000278139,
GENERIF_SUMMARY IGF2-PIK3R3 signaling axis is involved in promoting the growth of a subclass of highly aggressive human glioblastomas that lack EGF receptor amplification., We have identified novel nonclassical mediators of the SREBP-1 response, including p55gamma, supporting the hypothesis that SREBP-1 regulates stress response and signaling genes., A fusion peptide containing the p55PIK amino terminus, TAT-N24, which not only inhibited cell proliferation, but also stimulated differentiation., PIK3R3 was up-regulated in gastric cancer and promoted cell cycle progression and proliferation., Data show that miR-7 inhibits the effects of TLR9 signaling on lung cancer cells through regulation of the PIK3R3/Akt pathway., p55PIK is transcriptionally activated by MZF1, resulting in increased proliferation of colorectal cancer cells, Containing the N24 of PI3K-p55PIK., our results show that the-PCNA interaction is important in regulating DNA synthesis and contributes to tumorigenesis., p55PIK could be a substrate of activated caspase 6 during paraquat-induced apoptosis, leading to loss of original biological functions and redistribution to disturb cell cycle progression., discovered that ERBB4 and S6K2 were the direct targets of miR-193a-3p and that PIK3R3 and mTOR were the direct targets of miR-193a-5p in non-small-cell lung cancer, study shows that the p53/miR-148b/p55PIK axis has an important role in cell proliferation and tumor growth, and may represent a novel therapeutic target for treating cancers containing p53 mutations or losses., Overexpression of PIK3R3 depends on SNAI2, inducing significant epithelial-to-mesenchymal transition (EMT)., PIK3R3, ITGB1, ITGAL, and ITGA6, were involved in the regulation of actin cytoskeleton that link to triple-negative breast cancer migration., TGF-beta/NKX2.1/PIK3R3 axis is crucial in the TGF-beta-induced inhibition of cell proliferation, and the NKX2.1/PIK3R3 axis might become a target in TGF-beta receptor-repressed lung adenocarcinoma, p55gamma sequentially up-regulated p53 and p21, resulting in cell-cycle arrest in S phase; small-interfering RNA knockdown of either p53 or p21 blocked p55gamma-induced vascular smooth muscle cell growth arrest., our findings provide new insights into tumor suppression by miR-511 by negatively regulating the PIK3R3/AKT/mTOR signaling pathway, PIK3R3 was identified as a crucial target gene of miR-132., The proliferation, migration and invasion was decreased in ovarian SKOV3 when HOTAIR or PIK3R3 was silenced.,
SP_COMMENT function:Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1., similarity:Belongs to the PI3K p85 subunit family., similarity:Contains 2 SH2 domains., subunit:Heterodimer of a p110 (catalytic) and a p55 (regulatory) subunits., tissue specificity:Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle.,