Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
The Database for Annotation, Visualization and Integrated Discovery
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DAVID Functional Annotation Table
Gene Report
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transcription factor 7 like 1(TCF7L1) transcription factor 7 like 1(TCF7L1) Related Genes Homo sapiens
CHROMOSOME 2,
CYTOBAND 2p11.2,
ENSEMBL_GENE_ID ENSG00000152284,
GENERIF_SUMMARY No difference in nuclear beta-catenin signal intensity was found, which may be caused by an alteration in Wnt pathway in microsatellite stable sporadic tumors by unknown mechanisms leading to lower TCF-3, 4 protein expression., Data indicate that median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis., report the identification of two independent missense variants in human TCF7L1, p.R92P and p.R400Q, in a cohort of patients with forebrain and/or pituitary defects,
SP_COMMENT domain:The putative Groucho interaction domain between the N-terminal CTNNB1 binding domain and the HMG-box is necessary for repression of the transactivation mediated by TCF7L1 and CTNNB1., function:Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance., similarity:Belongs to the TCF/LEF family., similarity:Contains 1 HMG box DNA-binding domain., subunit:Binds the armadillo repeat of CTNNB1 and forms a stable complex., tissue specificity:Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium.,