Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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Wnt family member 5B(WNT5B) Wnt family member 5B(WNT5B) Related Genes Homo sapiens
CYTOBAND 12p13.3,
GENERIF_SUMMARY WNT5b is upregulated by beta-estradiol in tumor cell lines, WNT5B gene may contribute to conferring susceptibility to type 2 diabetes and may be involved in the pathogenesis of this disease through the regulation of adipocyte function., In leiomyoma cells, the regulation of Wnt5b expression by retinoids appears to be attenuated., Variation in WNT5B predisposes to type 2 diabetes in the absence of obesity., Results demonstrated significant up-regulation of WNT-3, WNT-4, WNT-5B, WNT-7B, WNT-9A, WNT-10A, and WNT-16B in patients with CLL compared to normal subjects., This is significantly related to fat cell differentiation, suggesting its possible involvement in the onset of diabetes mellitus type 2 and metabolic syndrome., Differentiation paralleled the activation of Wnt5/Calmodulin signalling by autocrine/paracrine intense secretion of Wnt5a and Wnt5b, This study shows that the WNT5B germline variant rs2010851 was significantly identified as a stage-dependent prognostic marker for CC patients after 5-fluorouracil-based adjuvant therapy., TGF-beta/Smad, integrin/integrin-linked kinase (ILK) and wnt/beta-catenin signaling pathways are involved in epithelial to mesenchymal transition in human renal fibrogenesis., These results indicate that Wnt5b is involved in the migration ability of OSCC cells through active Cdc42 and RhoA., WNT3 and WNT5B are critical factors, secreted from mesenchymal cancer cells, for instigating the epithelial cancer cell invasion., Ursolic acid suppressed the expression of Wnt5alpha/beta and beta-catenin, inducing apoptosis in prostate cancer cells., WNT5B is elevated in both in the tumor and the patients' serum from triple negative breast cancer., Knocking down Wnt5b expression reduced phospho-PKCA levels and cell migration., Report increased Wnt5b levels in adriamycin treated liver cancer stem cells within 4h of treatment., Results demonstrate that the Wnt5B pathway may play an important role in atypical teratoid rhabdoid tumor biology., The interaction between Wnt isoforms and their LRP6 cognate receptor depends on the jutting loop present in Wnt3a but absent in Wnt5b.,
SP_COMMENT function:Ligand for members of the frizzled family of seven transmembrane receptors., function:Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters., similarity:Belongs to the Wnt family., subunit:Interacts with PORCN.,