Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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Nanog homeobox(NANOG) Nanog homeobox(NANOG) Related Genes Homo sapiens
CYTOBAND 12p13.31, 15q14,
GENERIF_SUMMARY mouse and human Nanog and Nanog2 genes may have a common role in the maintenance of pluripotency in both species, Ten processed NANOG pseudogenes are identified in the complete human genome., demonstrated changes in DNA methylation in the promoter regions of Nanog and Oct-4 in a human cell line during retinoic acid-induced differentiation, Gene knockdown of Nanog promotes differentiation, thereby demonstrating a role for these factors in human embryonic stem cell self-renewal., NANOG is a new marker for testicular carcinoma in situ and germ cell tumours., findings suggest that NANOG acts as a gatekeeper of pluripotency in human embryonic stem and carcinoma cells by preventing their differentiation to extraembryonic endoderm and trophectoderm lineages, The NANOG protein co-occupy a substantial portion of its target genes, and collaborate to form regulatory circuitry consisting of autoregulatory and feedforward loops., We conclude that, despite the difference in primary structure and expression pattern in various stem cells, the alternatively-spliced variant of Nanog has similar activity to that of the full length version., NANOG overexpression in human embryonic stem cells enables their propagation for multiple passages during which the cells remain pluripotent, Nanog possesses an oncogenic potential that may be related to the role it plays in germ cell tumors and to its function in self renewal of ES cells., These results suggest that NANOG plays a crucial role in maintaining the pluripotent state of primate embryonic stem cells., A series of deletion and site-directed mutagenesis within the homeodomain revealed that two basic NLS motifs are located at the N-terminus and C-terminus of the homeodomain and that both motifs are required for complete hNanog nuclear localization., Nanog is described in this review as a unique homeobox transcription factor and key downstream effector of extrinsic signals of embryonic stem cell self-renewal and pluripotency., reprogramming of DNA methylation and histone modifications on regulatory regions of the developmentally regulated OCT4 and NANOG genes, knock-downs of NANOG produced a proliferation rather than a differentiation phenotype in EC cells, Hence, Nanog does not inhibit terminal differentiation of committed cells but it is an inhibitor of trans-differentiation that is dependent on de-novo activation of gene transcription., the CD2 domain of Nanog is a unique transactivator that utilizes aromatic residues to confer specific activity absolutely required for ES self-renewal., Sox2-expressing MSCs showed consistent proliferation and osteogenic capability in culture media containing bFGF, The human primordial germ cells is the first primary cell type described to express POU5F1 and NANOG but not SOX2., Sox2, Oct4 and Nanog are linked together in a pluripotent regulatory network, SMAD 2/3 signaling directly supports NANOG expression, while SMAD 1/5/8 activation moderately represses SOX2., may be involved in carcinogenesis of the cervix and progression of cervical carcinoma, Immunohistochemical localization of nanog in stem cell compartments of human sacrococcygeal teratomas., HA binding to tumor cells promotes Nanog protein association with CD44 followed by Nanog activation and the expression of pluripotent stem cell regulators, and forms a complex with Stat-3 in the nucleus leading to Stat-3 and MDR1 activation, Oct-4 and Nanog may have roles in oral cancer stem-like cells and high-grade oral squamous cell carcinoma, an essential role in sustaining human embryonic stem cells self-renewal, These findings suggest that NANOG is involved in the pathogenesis and clinical progress of gestational trophoblastic disease, likely through its effect on apoptosis, cell migration, and invasion., Identification of the OCT4-pg1 retrogene and NANOG gene expression in the human embryonic eye, Esrrb coordinates with Nanog and Oct4 to activate the internal machinery of ES cells, Effects of ectopic Nanog and Oct4 overexpression on mesenchymal stem cells., NANOG regulates S-phase entry in human embryonic stem cells (hESCs) via transcriptional regulation of cell cycle regulatory components., Results identified two distinct transactivation domains in the C-terminal domain of human NANOG, which function in a synergistic manner to activate transcription in pluripotent human embryonic carcinoma cells., Nanog in turn prevents neuroectoderm differentiation induced by FGF signalling and limits the transcriptional activity of the Smad2/3 cascade, blocking progression along the endoderm lineage, a detailed characterization of the functional domains in the human (h) NANOG protein, NANOG, a cell-fate regulatory molecule known to be important for embryonic stem cell self-renewal, also plays a novel role in tumor development., Studies show that the expression of genes belonging to the OCT3/SOX2/NANOG/KLF4 core circuitry that acts at the highest level in regulating stem cell biology., This study evaluates the use of the markers, podoplanin, SOX2, NANOG, and OCT3/4 in ovarian tumors, Data showed that both KLF4 and PBX1 mRNA and protein expression were downregulated during hESC differentiation. Overexpression of KLF4 and PBX1 upregulated NANOG promoter activity and NANOG protein expression., Findings indicate that overexpression of stemness gene Nanog in NCCIT cells is associated with maintaining stem cell-like phenotype and suggest that targeting Nanog might be an approach for improved therapy of poorly differentiated tumors., Results indicate that HA binding to CD44 promotes PKCepsilon activation, increases the phosphorylation of the stem cell marker, Nanog, leads to microRNA-21 (miR-21) production and PDCD4 reduction., Nanog mRNA might be a new tool to support the diagnosis of lung cancers, irrespective of the clinical stage., Myostatin or 20 ng/mL BMP-11 maintain the colony and cellular morphology of undifferentiated hESC, maintain POU5f1, NANOG, TRA-1-60, and SSEA4 expression, and display increased SMAD2/3 phosphorylation, Nanog maintains human chondrocyte phenotype and function in vitro., Satb1 and Satb2 bind the Nanog locus in vivo and the balance of Satb1 and Satb2 contributes to the plasticity of Nanog expression and ES cell pluripotency, Self-renewal gene Nanog has a prognostic role in CRC, which functions in progression of CRC by promoting proliferation, invasion, and motility of human CRC cells, and participates EMT process during CRC progression., Klf4 functions upstream of Nanog in ES cell self-renewal and in preventing ES cell differentiation, Data show that a significant number of the genes contained binding sites for the stem cell transcription factors Oct4 and Nanog., The strong expression of Oct4 and Nanog in metaplastic ducts and Oct4 expression preceding Ras mutation suggests that they are associated with the early stage of pancreatic cancer carcinogenesis and may play an important role in that process., Results revealed that NANOG1 and NANOG2 protein variants are functionally equivalent and activate a regulatory circuit that activates specific stem cell genes., The presence of nanog, Oct-4, SSEA-1, and SSEA-4 suggests that periodontal ligament mesenchymal stem cells are less differentiated than bone marrow-derived MSCs, and that the frizzled-9/Wnt pathway is important in proliferation and differentiation., results demonstrate that hADCs were an ideal somatic cell resource for the rapid and efficient generation of iPS cells by OCT4/SOX2/NANOG, findings of the current study strongly suggest a conserved role for NANOG in meiotic and post-meiotic stages of male germ cell development, find that NANOG modulates gliomasphere clonogenicity, CD133(+) stem cell cell behavior and proliferation, downstream effectors of Hedgehog activity, Gli1 and Gli2, bind to Nanog-specific cis-regulatory sequences both in mouse and human stem cells., Data show that phosphorylation promotes the interaction between Nanog and the prolyl isomerase Pin1, leading to Nanog stabilization by suppressing its ubiquitination., expression in bone marrow-derived mesenchymal stem cells did not differ between children and adults, results provide proof that hGMDCs can be reprogrammed into pluripotent cells by ectopic expression of three factors (OCT4, SOX2, and NANOG) without the use of oncogenes c-MYC and KLF4, All cultured mesenchymal stem cells (MSC) populations, independently from the tissue of origin, express the embryonic transcription factor NANOG, whereas OCT-4 and SOX-2 are not expressed., methylation of CpGs in the NANOG promoter in germ cell tumors and derived cell lines correlated to differentiation state., Sall1 is expressed in a differentiation-dependent manner and physically interacts with Nanog and Sox2, two components of the core stem cell pluripotency network, Results indicate that mature endothelial cells re-express Nanog in response to Wnt3a stimulation. In these cells increased Nanog expression binds to and activates the Flk1-promoter to increase neovascularization., conclude that eNANOG is not exclusively expressed in undifferentiated cells and that both embryonic NANOG and NANOGP8 may function as transcription factors in a cell type-specific manner, Sox2 and Oct3/4 might be independent prognostic factors for patients with gastric cancer., NANOG plays an important role in maintaining the immunomodulation functions of mesenchymal stem cells by regulating the expression and secretion of TGF-beta and DKK-1, results demonstrate that hNanog is a potent human oncogene and has the ability to induce cellular transformation of human cells, The expression intensity of Nanog in normal ovarian tissue, benign, borderline, and malignant tumors showed a gradual rising trend. Among serous cystadenocarcinomas, 42% were positive for stage I, 70% for stage II, 95% for stage III, and 100% for stage IV, we have identified a potential PEST motif sequence within NANOG and demonstrated its importance in the enhancement of NANOG ubiquitination and subsequently protein degradation, Overexpression of Nanog protein is associated with gastric adenocarcinoma., FGF2 signaling switches the outcome of BMP4-induced differentiation of human embryonic stem cells by maintaining NANOG levels through the MEK-ERK pathway., Overexpression of Nanog in endometrial adenocarcinoma suggests that Nanog may represent a potential therapeutic target for endometrial adenocarcinoma, NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation, L1TD1 is a downstream target of Nanog and represents a useful marker for identifying undifferentiated hESC, in human embryonic stem cells nocodazole reversible blocks cell cycle, which is accompanied by irreversible loss of expression of pluripotency markers Nanog and Oct4, NANOG may contribute to the existence of brain tumor stem cells and may be related to tumorigenesis of the cerebrum, Findings show that c-Met enhances the population of glioblastoma stem cells via a mechanism requiring Nanog and potentially other c-Met-responsive reprogramming transcription factors., Cell line experiments involving siRNA knockdown of LIN28, OCT3/4 and SOX2 showed that LIN28 plays a role in the maintenance of the undifferentiated state of both seminoma and embryonal carcinoma, closely linked to, and likely upstream of OCT3/4 and NANOG, novel Nanog/Stat-3 signaling pathway-specific mechanism involved in miR-21 production is significant for the formation of future intervention strategies in the treatment of HA/CD44-activated HNSCC, These results indicate that the Tcf/Lef response element in the enhancer region of the human NANOG gene is able to stimulate NANOG gene transcription., Stable miR-302-367 cluster expression results in inhibition of CXCR4 leading to the disruption of the sonic hedgehog (SHH)-GLI-NANOG network., CD24 was found to be a functional liver tumor-initiating cells (T-IC) marker that drives T-IC genesis through STAT3-mediated NANOG regulation., These findings suggest that Nanog promotes dedifferentiation of p53-deficient mouse astrocytes into cancer stem-like cells by changing the cell fate and transforming cell properties., Data show that nuclear expression of the pluripotency-associated stem cell marker complex OCT4/SOX2/NANOG was confirmed in ISCs., this study is the first to show that hypoxia-induced NANOG plays a critical role in tumor cell response to hypoxia, Alternative splicing produces Nanog protein variants with different capacities for self-renewal and pluripotency in embryonic stem cells, TCam-2 cells up-regulate endoderm- and throphectoderm-associated genes after down-regulation of NANOG expression., We found a positive correlation between the expression levels of Oct4, Sox2 and Nanog and tumour malignancy in human glioma, these data indicate that nanog1 and nanogp8 are differentially expressed in colon cancer cells, and suggest that their expression contributes to proliferation of colon cancer cells., Data show that the suppression of NANOG displayed an effective differentiation toward endoderm and pancreatic progenitors., Data show that the expressions of Oct3/4 and Nanog were upregulated upon stimulation with Stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF)., Nanog expression enhanced the stem-like features of tumor cells and protected them from killing by tumor-reactive CTLs, Ectopic overexpression of NANOG via lentiviral transduction further recapitulates saRNA results, providing proof-of-concept that RNAa may be utilized to activate development-related genes and manipulate cell fate, Both Oct4 and Nanog were highly expressed in CD24(+)CD44(+) pancreatic cancer stem cells., examination of global transcriptional changes after Nanog silencing followed by verification by Nanog overexpression has revealed new molecules involved in the maintenance of self-renewal and in the regulation of the p53- and cell cycle-pathway, our findings establish a molecular basis for the role of NANOG in modulating cell cycle progression of breast cancer cells, Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells., data demonstrate the regulation of the FAK promoter by Nanog, the direct binding of the proteins, the phosphorylation of Nanog by FAK, and the effect of FAK and Nanog cross-regulation on cancer cell morphology, a NES motif is present in the hNANOG HD and may be functionally involved in CRM1-mediated nuclear export pathway., Our study showed that Nanog might be helpful in sustaining the self-renewal and the undifferentiation of prostate cancer stem cells, and may serve as a marker for prostate cancer stem cells for isolation and identification., NANOG stimulates the growth and metastasis of breast cancer cells and breast cancer patients with strong expression of NANOG had significantly lower disease-free survival., Nanog expression was related to histological grade, lymph node metastasis, TNM stage, and liver metastasis., cryopreservation of amniotic fluid does not alter karyotype, NANOG/SOX2 gene expression, or multipotent capacity of stem cells that have been collected from amniotic fluid during pregnancy, Nanog pseudogene8 is involved in GI cancer development in a fraction of patients, in whom it presumably acts by supporting cancer stem cell proliferation, NANOG is a cervical cancer progression marker., The introduction of Nanog was sufficient to alter the expression of key genes of the pluripotent pathway., Both mRNA and protein-level Nanog are overexpressed in ESCC tissues., Co-localization of NANOG and OCT4 in human pre-implantation embryos from morula and blastocyst stages and in human embryonic stem cells, Data indicate that stem cell-related transcription factors Nanog, Oct-4 and Sox-2 were positively expressed in umbilical cord (UC)-mesenchymal stem cells (MSCs)., Oct4 and Nanog directly regulate Dnmt1 to maintain self-renewal and undifferentiated state in mesenchymal stem cells, Hyaluronan-CD44v3 interaction with Oct4-Sox2-Nanog promotes miR-302 expression leading to self-renewal, clonal formation, and cisplatin resistance in cancer stem cells from head and neck squamous cell carcinoma., Data indicate that Nanog(high)/EpCAM(high) samples represent a tumor-initiating cells (TICs) subset which may be either M- or S-type, and which is separate from the CD44(high)/Oct-4A(high) subset observed only in M-type samples., Developmental failure of human ICSI embryos was not associated with high methylation of the Nanog promoter., the critical role of miR-214 in OCSC via regulation of the p53-Nanog axis and miR-214 as a therapeutic target for ovarian cancer., REVIEW, The association between NANOG expression and clinical outcome of patients with ovarian cancers., Nanog may be used to overcome the effects of organismal aging on aBM-MSC, thereby increasing the potential of MSC from aged donors for cellular therapy and tissue regeneration., first evidence that NANOG is a transcriptional activator of the expression of the oncogenic growth factor GDF3 in embryonic carcinoma cells, Data suggest that expression of NANOG and Oct4/POU5F1B (POU class 5 homeobox 1B) is up-regulated in visceral adipose tissue stem cells in type 2 diabetes as compared to control; expression is also up-regulated in hyperglycemic conditions., Expression of Nanog and LGR5 in normal ovaries and in borderline tumors may assist in the early detection and improved prognosis of ovarian cancer, Nanog signaling in cancer promotes stem-like phenotype and immune evasion., NANOG has potential as a predictor of survival for patients with ovarian carcinomas and may be involved in the mechanism of chemoresistance., Results indicate positive expression of SOX2, SOX3, PAX6, OCT3/4, and NANOG in the CD105+ and CD105(-) cell subpopulations., OAC1 increases transcription of the Oct4-Nanog-Sox2 triad and Tet1, a gene known to be involved in DNA demethylation, The sensitivity of cisplatin was decreased with increased expression of Nanog. Nanog expression could promote the proliferation and invasiveness of the cancer cells, and inhibit the apoptosis., role of NANOG heterogeneity in human embryonic stem cell division, an independent public expression profiling data showed signature for Oct4, Lin28 and Nanog could successfully be used to predict the survival of colorectal cancer patients, Nanog has a role in supressing cell migration., Data indicate that the stem cell markers, Nanog, Oct-4 and SOX-2, were significantly upregulated in cisplatin resistant (CisR) lung cancer cell lines., expression and prognostic impact of SOX2, OCT4, Nanog and Nestin in nasopharyngeal carcinoma, NANOG was upregulated during malignant progression., the islet's beta cells, expressing LGR5 and Nanog markers are the initiating cells of pancreas cancer and Nanog is a major biomarker for pancreatic ductal adenocarcinomas, MiR-134 could play an important role as a tumor suppressor relying on its direct translational attenuation of Nanog, data suggest that Oct4 and Nanog are not expressed in tumor cells that arise in the autochthonous cancer models studied here, a significant correlation between the NANOG expression and the expression of NODAL, P-SMAD3 or SNAIL, and the combination of NANOG and P-SMAD3 is a potential predictor of poor prognosis of HCC., Knockdown of protein kinase C alpha and delta enhances nanog expression in cancer cell lines., Linc-RoR (long intergenic non-protein coding RNA regulator of reprogramming) regulates endogenous Oct4, Nanog, and Sox2 expression in self-renewing and differentiating human embryonic stem cells., The identification of an abundant population of tryptase(+)/Nanog(+) cells in infantile haemangioma is novel., beta-catenin accumulation in the nucleus regulates expression of Nanog protein and has a role in progression of non-small cell lung cancer, This network was rearranged during differentiation and restored in induced pluripotent stem cells. A large fraction of Nanog-interacting loci were bound by Mediator or cohesin in pluripotent cells., A positive correlation of Pin1 and Nanog expression in human gliomas was noted., Data indicate that post-translational phosphorylation of Nanog is essential to regulate Bmi1 and promote tumorigenesis., the expression of Oct-4, Nanog, Sox-2 and Stat-3 are related to differentiation in ameloblasts and odontoblasts., findings demonstrate the involvement of Nanog in breast cancer metastasis, and provide the basis for the reported correlation between Nanog expression and poor prognosis of human breast cancer patients, nanog may identify multipotent brain tumor stem cells., Knockdown of Oct4 and Nanog significantly reduced proliferation, migration, invasion, chemoresistance, and tumorigenesis of pancreatic cancer stem cells in vitro and in vivo., NANOG expression in multipotent mesenchymal stem cells is not significantly different among chorionic villi, amniotic fluid, and placenta, High Nanog expression is associated with lung cancer., There was also no association between positive Oct4 and Nanog reactivity and tumor morphology, age, mitosis-karyorrhexis index, NMYC amplification, favorable or unfavorable histology, and risk groups., Amniotic fluid-derived stem cells (AFSc) seem to express Nodal, Nanog and DAZL and it speculated that the regulation of self-renewal in AFSc could be similar as in human embryonic stem cells., Core is capable of up-regulating NANOG expression, Stem Cell quantification defined by CD133 and NANOG expression has no correlation with relapse-free-survival or overall survival in this cohort of Stage II colon cancer., Unique biochemical properties of Nanog1 in embryonal carcinoma cells and NanogP8 in somatic cancer cells., Findings suggest that the knockdown of NANOG in HepG2 human cells resulted in decreased MDR1 expression and increased doxorubicin sensitivity., The positive correlation among Oct-4, Nanog, and beta-catenin suggests their coordinated role in maintaining proliferation in oral carcinoma cells., Phosphorylation of Nanog by ERK1 decreases Nanog stability through ubiquitination-mediated protein degradation., Data suggest expression of NANOG and SOX2 (sex determining region Y-box 2) is up-regulated in endometriotic ovary tissue of women with ovarian endometriosis as compared to endometrial tissue from these women or infertile women without endometriosis., This review features of core transcription factors Oct4, Sox2 and Nanog and their role in embryogenesis and tumorigenesis including the Cancer stem cell hypothesis., Report increased nanog levels in adriamycin treated liver cancer stem cells., Data demonstrate that inhibition of Snail-induced Nanog expression during EMT., Although NANOG was required for cardiac specification but blocked somitic subtypes, CDX2 was required for somitic mesoderm but blocked cardiac differentiation., Gene networks of fully connected triads (Oct4-SOX2-NANOG) with complete autoactivation enable multistability and stepwise stochastic transitions in cell differentiation fates., prognostic value of ALDH-1, Bmi-1 and Nanog stem cell markers in esophageal squamous cell carcinoma., Nanog is a novel oncogenic AR target gene in prostate cancer cells, and stable expression of Nanog increases proliferation and growth of prostate cancer cells, but not resistance to enzalutamide or docetaxel, Inhibition of NANOGP8 or NANOG enhances the cytotoxicity of BH3 mimetics., NANOG may play a significant role in carcinogenesis via its activation of c-Jun expression., Data suggest that combination of genetic variants of Oct-4 Transcription Factor, Nanog homeobox protein, and transcription factor SOX-2 gene may have a profound effect in breast cancer risk and response to neo-adjuvant chemotherapy., Disruption of Nanog may reverse the status of epithelial-mesenchymal transition, which is critical in tumorigenesis, and alleviate chemoresistance, as well as their invasiveness, in cervical cancer cells., HIF-2alpha regulates NANOG expression in human embryonic stem cells following hypoxia and reoxygenation through the interaction with an Oct-Sox cis regulatory element., Nanog overexpression is associated with epithelial-mesenchymal transition of breast cancer stem cells., The expression profile of Oct4 and Nanog in dental pulp cells, which exerted properties of mesenchymal stem cells was significantly up-regulated compared to that of STRO-1-CD146- dental pulp cells., Slug promotes progression of hepatocellular carcinoma by promoting sox2 and nanog overexpression., ectopic expression of Oct-4 gene in hAFMSCs with high self-renewal ability could upregulate Nanog and Sox-2 gene expression, Data indicate that coactivator-associated arginine methyltransferase 1 (CARM1) regulates neural differentiation through Nanog homeobox protein and microRNA miR92a., Reduced tumorigenicity and drug resistance through the downregulation of octamer-binding protein 4 and Nanog transcriptional factor expression in human breast stem cells, prolonged expression upon differentiation in METTL3-depleted embryonic stem cells, Different simple and complex decoys against Nanog, OCT-4, Sox2, and Klf4 were designed and used for this purpose. The results showed that the applied decoys especially Nanog-specific decoy decreased the expression of downstream genes., The concurrent expression of OCT4/NANOG/IGFIR was mostly confined to hepatitis B virus (HBV)-related HCC (HBV-HCC) and was significantly correlated with early tumor recurrence., The gastric carcinoma xenograft volume and mass are decreased by the overexpression of Nanog short-hairpin RNA., NANOG may be the most likely candidate protein interacting with OY-TES-1 in liver cancer. OY-TES-1 downregulation in liver cancer cells inhibits cell proliferation by upregulating CD and downregulating NANOG., Magnetofection-mediated NANOG delivery increased proliferation and enhanced the differentiation of hair follicle derived mesenchymal stem cells into smooth muscle cells., NANOG potentiates the molecular circuitry of tumorigenesis, and thus may represent a novel therapeutic target or biomarker for the diagnosis, prognosis, and treatment outcome of cancer., Data show that when overexpressed in epiblast stem cells, or induced pluripotent stem cells, the NANOG transcription factor L122A mutants enhanced reprogramming into ground-state pluripotency., Prolonged proteasome inhibition cyclically upregulates gene expression of Oct3/4 and Nanog, but reduces colony formation in the presence of the iPSC induction cocktail., We illustrate that coexpression of Oct4 and Nanog initiates stem cell characteristics in hepatocellular carcinoma and promotes epithelial-mesenchymal transition, Increased expression of NANOG is associated with metastatic capability of immunoedited tumor cells., The current review provides a most updated summary on how NANOG expression is regulated during tumor development and progression. [review], Nanog is an oncogene with multiple roles in promoting tumorigenesis and metastasis, NANOG-NUMB-p53 signaling axis is an important regulatory pathway for tumor-initiating cells events in TIC self-renewal and liver tumorigenesis, Oct3/4 and Nanog represent probable CSC markers in HNSCC, which contribute to the development of DNM in part by enhancing cell motility and invasiveness., The outcomes of this study, for the first time, unravels the importance of particular genomic features in Nanog gene evolution paving roads toward better understanding of stem cell development and human targeted disorder therapy, The promoter activity of Nanog and Oct4 were upregulated, and beta-catenin was observed to bind to these promoters during H. pylori infection, while a Wnt/beta-catenin inhibitor suppressed promoter activity and binding.,
SP_COMMENT developmental stage:Expressed in embryonic stem (ES) and carcinoma (EC) cells. Expressed in inner cell mass (ICM) of the blastocyst and gonocytes between 14 and 19 weeks of gestation (at protein level). Not expressed in oocytes, unfertilized oocytes, 2-16 cell embryos and early morula (at protein level). Expressed in embryonic stem cells (ES). Expression decreases with ES differentiation., function:May act as a transcription regulator (By similarity). When overexpressed, promotes cells to enter into S phase and proliferation., function:Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes (By similarity). Acts as a transcriptional activator or repressor (By similarity). Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3' (By similarity). When overexpressed, promotes cells to enter into S phase and proliferation., miscellaneous:Almost identical to NANOG. There are only one change in the inferred amino acid sequence from 'Gln-253' in NANOG to His-253 in NANOGP8., miscellaneous:Exists an other tandem duplicated non-processed pseudogene (NANOGP1) and 10 other NANOG-related nucleotide sequences located on different chromosomes, all of which are processed pseudogenes lacking introns (NANOGP2 to NANOGP11); except NANOGP8 which is a retrogene., online information:Nanog entry, similarity:Belongs to the Nanog homeobox family., similarity:Contains 1 homeobox DNA-binding domain., subunit:Interacts with SMAD1 and SALL4., tissue specificity:Expressed in osteosarcoma cancer cell line (at protein level) (Probable). Expressed in tumor uterine cervix, breast and urinary bladder tissues, and also osteosarcoma, hepatoma, and breast adenocarcinoma cancer cell lines., tissue specificity:Expressed in testicular carcinoma and derived germ cell tumors (at protein level). Expressed in fetal gonads, ovary and testis. Also expressed in ovary teratocarcinoma cell line and testicular embryonic carcinoma. Not expressed in many somatic organs and oocytes.,