Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
The Database for Annotation, Visualization and Integrated Discovery
DAVID Functional Annotation Table
Gene Report
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YES proto-oncogene 1, Src family tyrosine kinase(YES1) YES proto-oncogene 1, Src family tyrosine kinase(YES1) Related Genes Homo sapiens
CYTOBAND 18p11.31-p11.21,
GENERIF_SUMMARY cAMP activates while Ca(2+) inhibits human sperm c-yes kinase activity, QM binds to c-yes at the SH3 domain in tumor cell lines, This review summarizes the potential functions of c-Yes and its ability to modulate signals that are distinct from c-Src., Src family kinase Yes triggers hyperosmotic activation of the epidermal growth factor receptor and CD95, activation of c-Yes is important for maintaining embryonic stem cells in an undifferentiated state, c-Yes 3'-UTR contains at least three newly identified adenine/uridine-rich elements (AREs) which are bound specifically by ARE-binding proteins HuR and AUF1., Vascular endothelial growth factor (VEGF)-induced cell migration is significantly decreased in Yes-deficient retinal microvascular endothelial cells., NFAT1, a transcription factor connected with breast cancer metastasis, is activated by Wnt-5a through a Ca2+ signaling pathway in human breast epithelial cells which was simultaneously counteracted by a Wnt-5a-induced Yes/Cdc42 signaling pathway., activation of the protooncogene product c-Yes may play a significant role in the malignant transformation of hepatocytes, The results were confirmed at the level of mRNA and protein, and suggested that four genes (OPCML, RNASE1, YES1 and ACK1) could play a key role in the tumorigenesis and metastasis of gastric cancer., Nucleus-located c-Yes may be a useful marker to detect early-stage hepatocellular carcinoma., Amyloid aggregation by an SH3 domain from the Src family., Thus, these results suggest that endogenous c-Src, c-Yes, and Lyn are differentially activated through Cdc2 activation during M phase., c-Yes induction results in increased colorectal carcinoma cell motility but did not promote proliferation. In later stages of colorectal carcinogenesis, elevations in c-Yes levels/activity may promote cancer spread & metastasis rather than tumor growth., Binding of CD95 Ligand to CD95 on glioblastoma cells recruit Yes and the p85 subunit of phosphatidylinositol 3-kinase to CD95, which signal invasion via the glycogen synthase kinase 3-beta pathway and subsequent expression of matrix metalloproteinases., These results suggest that SFK trafficking is specified by the palmitoylation state in the SH4 domain., Cloning of the complete coding sequence of the cDNA of the Csk and Yes tyrosine kinases genes of the human lymphocytes and retina have been carried out., Data show that found that IFIH1, a susceptibility gene of type 1 diabetes, interacts with YES1, which plays a role in glucose transport., Study identified the previously reported pathogenic mutation of NTRK3 in a KRAS/BRAF wild-type tumor and 2 somatic mutations in the Src family of kinases (YES1 and LYN) that would be expected to cause structural changes., Both YES and STAT1 were verified as direct miR-145 targets, c-Yes was expressed in malignant melanoma, and squamous cell carcinoma type skin neoplasms., Yes-associated protein may play important roles in different pathways in distinct lung tumor subtypes., c-Yes regulates specific oncogenic signalling pathways important for colon cancer progression that is not shared with c-Src., Functional activation of Src family kinase yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3., Taken together, our findings demonstrate that Yes and Lyn phosphorylate EGFR at Y1101, which influences EGFR nuclear translocation in this model of cetuximab resistance., study concludes that Yes is a central mediator for malignant mesothelioma cell growth that is not shared with other Src family kinases such as c-Src, we identified CRKL/YES as critical interrelated pathways necessary for rhabdomyosarcoma cell growth and survival and suggest a potential therapeutic role of SRC family kinase inhibition in the treatment of rhabdomyosarcoma., Expression of HPV type 16 E7 resulted in increase in Src and Yes proteins level, but did not alter the level of Fyn., YES1 and YAP transcript levels were higher in liver metastases of patients with colon cancer after 5FU-based neoadjuvant chemotherapy., YES kinase as a proximal glucose-specific signal in the Cdc42-signaling cascade., results indicated that miR-17-5p might play a role in human ovarian cancer by up-regulating YES1 expression., Results demonstrate a unique role for Yes in phosphorylation of FAK and in promoting PCa metastasis. Therefore, phosphorylated FAK Y861 and increased Yes expression may be predictive markers for PCa metastasis., findings indicate that miR-203 induces the apoptosis of KB cells by directly targeting Yes-1, suggesting its application in anti-cancer therapeutics, Increased YES/SFK activation might serve as a clinical biomarker for predicting tumor resistance to IGF-1R inhibition.,
SP_COMMENT catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate., function:Promotes infectivity of Neisseria gonorrhoeae in epithelial cells by phosphorylating MCP/CD46., PTM:Autophosphorylated., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily., similarity:Contains 1 protein kinase domain., similarity:Contains 1 SH2 domain., similarity:Contains 1 SH3 domain., subcellular location:In epithelial cells infected with Neisseria gonorrhoeae, forms aggregates beneath bacterial microcolonies.,