Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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Wnt family member 10B(WNT10B) Wnt family member 10B(WNT10B) Related Genes Homo sapiens
GENERIF_SUMMARY pyrethroid insecticides and estrogen can enhance the expression of the WNT10B proto-oncogene, mutations represent the first naturally occurring missense variants of WNT10B, suggest that fibroblast growth factor switches WNT10B from a negative to a positive cell growth regulator, Metastatic osteosarcoma cell lines showed better chemotaxis response to Wnt10B than the non-metastatic osteosarcoma cell lines, By homozygosity mapping a novel Split-Hand/Foot Malformation locus at 12q13.11-q13 with a maximum multipoint lod score of 5.47; by subsequent candidate gene approach a homozygous missense WNT10b mutation was identified., This analysis implicates the WNT10B locus as a genetic element in the regulation of bone mass and structural geometry., In Wnt10b-expressing mammary tumors, levels of p27(KIP1) were extremely low; conversely, Wnt10b-null mammary cells expressed high levels of this protein, suggesting Wnt-dependent regulation of p27(KIP1)., S1P induces osteoblast precursor recruitment and promotes mature cell survival. Wnt10b and BMP6 also were significantly increased in mature osteoclasts, whereas sclerostin levels decreased during differentiation., We have not found evidence for a robust association of common WNT10B gene allelic variants with either BMD or fractures in postmenopausal women., This study is the first report of the association of common genetic polymorphism of WNT10B with human fat accumulation., Homozygous nonsense mutation in WNT10B is associated with sporadic split-hand/foot malformation with autosomal recessive inheritance., Wnt10b, but not Wnt3a, stimulates the NFkappaB and Notch pathways in U2OS osteosarcoma cells., A novel sequence variant (c.986C>G, p.Thr329Arg) of WNT10B has been identified in familial split-hand/foot malformations in a large consanguineous Pakistani family., Wnt/beta-catenin pathway forms a negative feedback loop during TGF-beta1 induced human normal skin fibroblast-to-myofibroblast transition, common variation in WNT10B was shown to be associated with BMI and weight in a case-control population of Belgian males., we identified WNT10B as a direct target of miR-148a in cancer-associated fibroblasts from endometrial cancers, Variations in WNT10B do not contribute to human monogenic obesity in our population., Results suggest that Wnt10b likely plays an important role in the development of endometrial cancer (EC). The results also identify a role for Wnt10b in EC cells through promoting proliferation and inhibiting apoptosis., WNT10B/beta-catenin signalling induces HMGA2 and proliferation in metastatic breast cancer tumours devoid of ERalpha, PR and HER2 expression., No association between WNT10B polymorphisms and adiposity parameters was found. However, a role for WNT10B variants in determining human bone mineral density was found., Hypoxia-inducible factor-2alpha-dependent hypoxic induction of Wnt10b expression in adipogenic cells., Sequence analysis of WNT10B gene revealed a novel 4-bp deletion mutation., these findings clearly demonstrate that Wnt10b promotes epidermal keratinocyte transformation through induced Egf pathway, Data show that Wnt protein Wnt10b is expressed in cardiomyocytes and localized in the intercalated discs of mouse and human hearts., WNT10B enhances proliferation through beta-catenin and RAC1 GTPase in human corneal endothelial cells.,
OMIM_DISEASE Split-hand/foot malformation 6,
SP_COMMENT developmental stage:Infant brain has higher levels of WNT10B than adult brain., function:Ligand for members of the frizzled family of seven transmembrane receptors., function:Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters., similarity:Belongs to the Wnt family., tissue specificity:Detected in most adult tissues. Highest levels were found in heart and skeletal muscle. Low levels are found in brain.,