Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
The Database for Annotation, Visualization and Integrated Discovery
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DAVID Functional Annotation Table
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Wnt family member 8B(WNT8B) Wnt family member 8B(WNT8B) Related Genes Homo sapiens
CHROMOSOME 10,
CYTOBAND 10q24,
ENSEMBL_GENE_ID ENSG00000075290,
GENERIF_SUMMARY significantly up-regulated in gastric cancer cell lines KATO-III (signet-ring cell carcinoma) and MKN45 (poorly differentiated adenocarcinoma), and also in 5 out of 10 cases of primary gastric cancer, Expression and regulation of WNT8B mRNA in human tumor cell lines, WNT8B expression in hepatocyte progenitors derived from human ES cells is due to POU5F1 (OCT3/OCT4) and GATA3, and WNT8B expression in diffuse-type gastric cancer is due to POU5F1 and GATA6, WNT8b and SHH mutations and abnormal expressions are present in the peripheral blood of children with sporadic Hirschsprung disease.,
SP_COMMENT function:Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus., similarity:Belongs to the Wnt family., tissue specificity:Expression is restricted to the brain, and more specifically to the forebrain.,