Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
The Database for Annotation, Visualization and Integrated Discovery
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DAVID Functional Annotation Table
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Wnt family member 7A(WNT7A) Wnt family member 7A(WNT7A) Related Genes Homo sapiens
CHROMOSOME 3,
CYTOBAND 3p25,
ENSEMBL_GENE_ID ENSG00000154764,
GENERIF_SUMMARY WNT7a gene expression is regulated by TGF-beta1 through the intracellular beta-catenin-TCF pathway, provides support that E-cadherin induction by WNT/beta-catenin signaling is an evolutionarily conserved pathway operative in lung cancer cells and that loss of expression may be important in lung cancer development or progression, WNT7A mutations are an unlikely cause of Mullerian duct derivative abnormalities in humans, Wnt-7a is associated with cartilage destruction by regulating the maintenance of differentiation status and the apoptosis of articular chondrocytes via different mechanisms, analysis of multiple Wnt mRNAs in non-small cell lung cancer (NSCLC) cell lines and primary lung tumors revealed markedly decreased Wnt-7a expression compared with normal short-term bronchial epithelial cell lines and normal uninvolved lung tissue, By regulating the proliferation of corneal epithelial cells, Wnt-7a and MMP-12 appear to contribute to corneal wound healing, Partial loss of WNT7A causes Fuhrmann syndrome, whereas the more severe limb truncation phenotypes observed in Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome result from null mutations., ERK5-dependent activation of PPARgamma represents a major effector pathway mediating the anti-tumorigenic effects of Wnt 7a and Fzd 9 in non-small cell lung cancer cells, the absence of tumour-specific somatic events in WNT7A and HDAC11 suggests that these genes are unlikely to have a classical tumour suppressor gene role in sporadic malignant pancreatic endocrine tumours, WNT7A plays a role in the pathophysiology of endometriosis., These biological tools could help lead to a better understanding of Wnt-Fzd interactions and the identification of new modulators of Wnt signaling., WNT7A gene is unlikely to be a major contributor to the aetiology of familial congenital talipes equinovarus, Based on these results it is unlikely CAND2 and WNT7a are the major genes that causes clubfoot., Mutations in the coding sequence of WNT4, WNT5A, WNT7A, and WNT9B are not responsible for the Mayer-Rokitansky-Kuster-Hauser syndrome., Female mammals with a deficiency in the product of Wnt7a gene are infertile as a result of abnormal development of the uterus and the oviducts., Results suggest that this diminished expression of the WNT7A gene may be related to a supposed protection of fragile X syndrome patients to develop cancer., The activity of the Sprouty4 promoter is increased by Wnt7A/Frizzled 9 homolog (Fzd9) signaling through peroxisome proliferator-activated receptor gamma in lung cancer cells., Expression levels of Wnt7A, beta-catenin, and FoxA1, along with cell-type specific markers, are observed to vary with differentiation and often also in response to the presence of heparin during the time of exposure to heparin., Abnormalities in the Wnt7a pathway (located in the dorsal ectoderm) produce several clinically relevant conditions., High Wnt7a expression in ovarian cancer may be associated with poor prognosis., A novel homozygous missense mutation in coding exon 4 of the WNT7A was detected in both affected daughters (c.664C > T) leading to an amino acid exchange from arginine to tryptophan (p.Arg222Trp; R222W)., Partial loss of WNT7A function resulted in Fuhrmann syndrome, while complete loss of WNT7A function resulted in the more severe phenotype of Al-Awadi-Raas-Rothschild syndrome., The novel missense homozygous mutation (p.Gly204Ser) in the WNT7A gene is a unique mutation in the degree of loss of function in the upper limb development which ranges from mild to complete absence of both upper limbs (amelia)., Mutations in the coding sequence of WNT7A are not responsible for mullerian duct abnormalities in the Chinese population., reexpression of WNT7A during malignant transformation of ovarian epithelial cells plays a critical role in ovarian cancer progression mediated by WNT/beta-catenin signaling pathway., Wnt7a has a role in postmenstrual regeneration and proliferation of endometrial glands and luminal epithelium in primates, Wnt7a is lost by methylation in a subset of tumors and that this methylation is maintained by DNMT1, Gene expression profiling identifies WNT7A as a key SVZ-glial factor lacking in OB-glia that enhances self-renewal, thereby improving the propagation of OB-NSC cultures., WNT7A gene is inactivated by genetic/epigenetic alterations in clear cell RCC and demonstrates tumor suppressor properties, Overexpression of Wnt7a may contribute to the progression of endometrial cancer and thus may serve as a new biomarker to predict the prognosis of endometrial cancer., Novel mutations in the WNT7A gene in two unrelated cases of Al-Awadi Raas-Rothschild syndrome., Binding of Wnt7a to Fzd7 leads to an activation of noncanonical Wnt signaling, resulting in directed myogenic stem cell migration and enhanced engraftment., findings suggest a central role of the WNT7A-PAX6 axis in corneal epithelial cell fate determination, and point to a new strategy for treating corneal surface diseases, Prognosis was significantly more favorable for patients with high Wnt7A expression., loss of the Wnt7a gene induced by promoter methylation might be a prognostic factor for non-small cell lung carcinoma, Wnt7a has a role in specifying the fate of neural crest-like cells via suppression of notch in the human skin microenvironment, identified Iloprost, a prostacyclin analog, which initiates downstream signaling cascades similar to that of Wnt7a, as a novel inducer of cellular senescence, presenting potential future clinical translational strategies, this is the first study reporting reduced WNT7A levels in cervical cancer -derived cells and that ectopic WNT7A restoration negatively affects cell proliferation and migration., Wnt7a overexpression is associated with an unfavorable prognosis and that positive Wnt7a may be an independent prognosis factor influencing OS and DFS prediction in colorectal cancer patients., Wnt7a is involved in the transformation of the retinal pigment epithelium.,
OMIM_DISEASE Fuhrmann syndrome, Ulna and fibula, absence of, with severe limb deficiency,
SP_COMMENT disease:Defects in WNT7A are a cause of Fuhrmann syndrome [MIM:228930]; also called fibular aplasia or hypoplasia femoral bowing and poly- syn- and oligodactyly. Fuhrmann syndrome is a distinct limb-malformation disorder characterized also by various degrees of limb aplasia/hypoplasia and joint dysplasia., disease:Defects in WNT7A are the cause of limb/pelvis-hypoplasia/aplasia syndrome (LPHAS) [MIM:276820]; also called absence of ulna and fibula with severe limb deficiency. LPHAS is a limb-malformation disorder characterized by various degrees of limb aplasia/hypoplasia and joint dysplasia., function:Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts., similarity:Belongs to the Wnt family., subunit:Interacts with PORCN., tissue specificity:Expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain.,