Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
The Database for Annotation, Visualization and Integrated Discovery
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DAVID Functional Annotation Table
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Wnt family member 6(WNT6) Wnt family member 6(WNT6) Related Genes Homo sapiens
CHROMOSOME 2,
CYTOBAND 2q35,
ENSEMBL_GENE_ID ENSG00000115596,
GENERIF_SUMMARY Wnt6 plays an important role in tooth development by promoting human dental papilla cell differentiation, without significant effects on cell proliferation., The WNT6 rs6747776 homozygous minor allele (CC) was associated with increased risk of colorectal adenoma., WNT6 and Cav1 are upregulated by chemotherapeutics and enhance the resistance of GC cells to anthracycline drugs, WNT6 activates the JNK signaling pathway in HDPCs, leading to migration and differentiation., analysis of missense mutation in WNT6 in couples with unexplained recurrent miscarriage,
SP_COMMENT function:Ligand for members of the frizzled family of seven transmembrane receptors., function:Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters., similarity:Belongs to the Wnt family., subunit:Interacts with PORCN.,