Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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Wnt family member 5A(WNT5A) Wnt family member 5A(WNT5A) Related Genes Homo sapiens
CHROMOSOME 3,
CYTOBAND 3p21-p14,
ENSEMBL_GENE_ID ENSG00000114251,
GENERIF_SUMMARY Frequent up-regulation of WNT5A mRNA in primary gastric cancer., Increased expression of WNT5a is associated with cell motility and invasion of metastatic melanoma, WNT5a is upregulated by TNF-alpha in tumor cell lines, Wnt-5a promotes T cell nuclear accumulation of the transcription factor NFAT in the presence of cyclosporin A., These results suggest that the TAK1-NLK MAPK cascade is activated by the noncanonical Wnt-5a/Ca(2+) pathway and antagonizes canonical Wnt/beta-catenin signaling., Results suggest that disabled-2 functions as a negative regulator of canonical Wnt signaling by stabilizing the beta-catenin degradation complex., Down-regulation of Wnt-4 and up-regulation of Wnt-5a are possible markers of the malignant phenotype of human squamous cell carcinoma., Altered mRNA expression is associated with prostate cancer recurrence., Their different spatial expression patterns suggest that Wnt4 and Wnt5a proteins are not functionally linked to type II collagen and type X collagen synthesis in in vitro chondrogenic models of mesenchyme stem cells, Wnt-5a is involved in the response of malignant neuroblasts to retinoic acid., Wnt-5a serves as an antagonist to the canonical Wnt-signaling pathway with tumor suppressor activity in differentiated thyroid carcinomas., Over-expression of Wnt5a in transgenic mice disrupts epithelial-response to FGF10 and regulates Shh signaling., function of Wnt 5a as either a suppressor or promoter of malignant progression seems to be modulated by intercellular interactions, The role of Wnt5A in the microenvironment of primary breast cancer and macrophage-induced breast cancer invasion., WNT5A and FZD5 regulate the microbially induced interleukin-12 response of antigen-presenting cells and interferon-gamma production by mycobacterial antigen-stimulated T cells, NFAT1, a transcription factor connected with breast cancer metastasis, is activated by Wnt-5a through a Ca2+ signaling pathway in human breast epithelial cells which was simultaneously counteracted by a Wnt-5a-induced Yes/Cdc42 signaling pathway., The Embryonic Lethal Abnormal Vision-like protein HuR, inhibited translation of Wnt-5a when bound to highly conserved AU-rich sequences in the 3'-untranslated region of the Wnt-5a mRNA., The aberrant expression of WNT5A suggest that the Wnt signaling pathway may be abnormally regulated in nasopharyngeal carcinoma (NPC), which provides insight into the molecular mechanisms of NPC., Screening for Wnt5a-regulated genes in cultured endothelial cells identified several encoding angiogenic regulators, including matrix metalloproteinase-1, an interstitial collagenase, and Tie-2, a receptor for angiopoietins., WNT5A is an important target of CUTL1 and mediator of invasiveness and tumor progression in pancreatic cancer., Wnt5A can signal via protein kinase C (PKC), so the role of PKC in Wnt5A-mediated motility and epithelial to mesenchymal transition was also assessed using PKC inhibition and activation studies, Wnt3A/5A can function as mesenchymal regulatory factors by providing instructive cues for the recruitment, maintenance, and differentiation of mesenchymal stem cells., Our findings demonstrate that APC status plays a key role as a determinant of Wnt5a secretion and suggest that CaSR-mediated secretion of Wnt5a will inhibit defective Wnt signaling in APC-truncated cells in an autocrine manner., Hypomethylation of wingless-related MMTV integration site 5A (WNT5A), S100 calcium-binding protein P (S100P) and cysteine-rich protein 1(CRIP1) was confirmed in the cancer cells by bisulfite sequencing., Ability of phenylmethimazole (C10) to decrease growth and migration of papillary thyroid cancer cells may be related to its suppressive effect on TLR3 and Wnt5a signaling., These results suggest that Wnt signaling crosstalk and functional antagonism with the LRP5 co-receptor are key signaling regulators of mesenchymal stem cells maintenance and differentiation., Data indicate that Wnt5a signaling is an important regulator in the proliferation of glioma cells., did not detect submicroscopic deletion or duplication nor sequence alteration in either CACNA2D3 or WNT5A in ZLS-affected individuals, Review about the different influences and signaling pathways of Wnt5A in tumor progression., The genesis of myelocytic leukemia is related to the down-regulated expression of Wnt5a., Wnt5a and Wnt11 expression in EPC cells was induced by coculture with rat neonatal cardiomyocyte and was blocked by gamma-secretase inhibition., Our findings suggest non-canonical Wnt signalling plays a role in regulating endothelial cell growth and possibly in angiogenesis., These data show activation of the Wnt/beta-catenin-signalling pathway in uveal melanoma and suggest that components of this pathway might be useful prognostic markers as well as attractive therapeutic targets to treat this disease., WNT5A, a putative tumour suppressor gene in ALL, is silenced by methylation in this disease and that this epigenetic event is associated with upregulation of CYCLIN D1 expression and confers poor prognosis in patients with ALL., WNT5A is frequently inactivated in CRC by tumor-specific methylation, and thus, is a potential biomarker., MT1-MMP-induced phenotypic changes were dependent upon up-regulation of Wnt5a, which has been implicated in epithelial-to-mesenchymal transition., Wnt5A is critically involved in inflammatory macrophage signaling in sepsis and is a target for antiinflammatory mediators like APC or antagonists like sFRP1., findings show cell-autonomous mechanisms allow Wnt5a to control cell orientation, polarity, and directional movement in response to positional cues from chemokine gradients, Wnt5a expressed in atherosclerotic lesions colocalizes with TLR-4., study demonstrated that Wnt3a & Wnt5a can promote proliferation of HEK293 cells & inhibit serum starvation-induced apoptosis, which implies Wnt3a & Wnt5a can maintain survival of HEK293 cells under stress, negative correlation between expression of Wnt-5a & hepatitis B virus x gene(HBx) mutations in hepatocellular carcinoma(HCC); it is concluded that HBx mutants may participate in development & progression of HCC, at least in part through the Wnt-5a pathway, No mutation found in Zimmermann-Laband syndrome, both Wnt5a and Wnt3a bound Ror2, only Wnt5a induced Ror2 homo-dimerization and tyrosine phosphorylation in U2OS human osteoblastic cells., Wnt3a and Wnt5a have roles in inducing BMP-4 and 6 expression in prostate cancer osteoblast differentiation, Data show that Wnt5a is highly expressed during osteoblastic differentiation, and that clusters of genes regulating cell cycle, cell proliferation and cell growth, and gene transcription are altered with absence of Wnt5a expression., Expression of Wnt5a plasmid but not Wnt1 or Wnt3a increased caudal homeodomain factor CDX2 transcripts and protein in HT-29 adenocarcinoma cells. Wnt5a increased activity of a sucrase-isomaltase (SI) promoter in Caco-2BBE cells., Cytoplasmic WNT5A increases with melanoma progression and strong expression is associated with poor outcome., LRP1 stimulates a canonical Wnt5a signaling pathway that prevents cholesterol accumulation., WNT5A is regulated by PAX2 and may be involved in blastemal predominant Wilms tumorigenesis, These data suggest that the epigenetic remodeling of the WNT5A promoter is correlated with its transcriptional activation and this upregulation likely participates in arsenical-induced malignant transformation., Amino acid limitation in colon cancer cells induces phosphorylation of ERK1/2, which then down-regulates WNT5a expression., Staining of a melanoma tissue array also highlighted the inverse relationship between MART-1 and Wnt5A expression., pathways related to Wnt5a have an important role in ovarian malignant neoplasia., Mutations in the coding sequence of WNT4, WNT5A, WNT7A, and WNT9B are not responsible for the Mayer-Rokitansky-Kuster-Hauser syndrome., Wnt5A activates calpain-1, leading to the cleavage of filamin A, which results in a remodeling of the cytoskeleton and an increase in melanoma cell motility, Data show that Wnt-5a stimulation of breast epithelial cells leads to increased cell-cell adhesion, and that Wnt-5a/casein kinase Ialpha (CKIalpha)-specific phosphorylation of beta-catenin leads to increased complex formation of beta-catenin/E-cadherin., WNT5A is a regulator of fibroblast proliferation and resistance to apoptosis., Wnt5a regulates epidermal differentiation even in adult skin, Expression of Wnt-5a protein significantly stimulated cell proliferation, and transfection with siRNA plasmids suppressed Wnt-5 expression and cell proliferation, may be an important marker during initial events of actinic cheilitis malignant transformation; might recruit other events in lip squamous cell carcinoma, such as matrix metalloproteinase 3 synthesis, Wnt5a enhances cardiac gene expressions of EPC via an activation of PKC delta, Wnt5A is a critical mediator of CXCL12-CXCR4 signaling and migration in human and murine T, Results indicate that Wnt5a/Ror2 signaling involves the activation of a SFK, leading to MMP-13 expression, and that constitutively active Wnt5a/Ror2 signaling confers invasive properties on osteosarcoma cells in a cell-autonomous manner., Laminin gamma2 mediates Wnt5a-induced invasion of gastric cancer cells., Phospho-DARPP-32 potentiates Wnt-5a-mediated CREB activity and suppresses filopodia formation., syndecan 1 and 4 correlate to increased metastatic potential in melanoma patients and are an important component of the Wnt5A autocrine signaling loop, WNT5A gene has been methylated from the early stages of colorectal cancers., Data show that ROR2 knockdown results in a decrease in signaling downstream of Wnt5A., Differential expression of Wnt ligands in HCC cells is associated with selective activation of canonical Wnt signaling in well-differentiated, and its repression in poorly differentiated cell lines., WNT5A, a putative tumor suppressor gene in acute myeloid leukemia (AML), is silenced by methylation in this disease and that this epigenetic event is associated with upregulation of CYCLIN D1 expression., WNT5A negatively regulates both proliferation and migration of HDPCs, suggesting its important role in odontogenesis via controlling the HDPCs., Wnt5a activated Rac in the beta-catenin-independent pathway, and Frizzled2 (Fz2) and Ror1 or Ror2 were required for this action., A WNT5A/ROR2 signal transduction pathway is important in craniofacial and skeletal development and proper formation and growth of these structures is sensitive to variations in WNT5A function., Data show that tumor spheroid cells express ABCG2, Bmi1, WNT5A, CD133, prox1 and VEGFR3., cGMP-phosphodiesterase 6 can be activated by another cancer-retina antigen, transducin, through Wnt5a-Frizzled-2 cascade, which leads to a lowering of cGMP and an increase in intracellular calcium mobilization., Wnt-5a regulates proliferation in lung cancer cells, WNT5A signaling is important in modulating tumorigenic behaviors of enamel epithelium cells in ameloblastomas., WNT-5a is necessary to maintain osteogenic potential of MSC and inhibition of WNT-5a signaling therefore plays a role in their determination into preadipocytes in humans, Wnt5A is not involved in the onset or progression of MCC and support other data that indicate that Wnt signaling is inactive in this cancer despite its neuroendocrine origins., Wnt5a promotes the aggressiveness of prostate cancer and that its expression is involved in relapse after prostatectomy., study suggest a shift away from canonical Wnt signaling toward noncanonical pathways driven by interactions between Wnt-5a and its cognate receptors in psoriasis, accompanied by impaired homeostatic inhibition of Wnt signaling by WIF-1 and dickkopf, stimulator of adipose tissue-derived mesenchymal stromal cells osteogenic differentiation, A quantitative analysis of the expression of Wnt5A protein in human tissue arrays, containing 600 prostate tissue cores, showed >50% increase in malignant compared to benign cores (p<0.0001)., expressions of mineralization-related genes, Data show that expression of Wnt5a in atherosclerosis and rheumatoid arthritis but not in normal tissue, supporting the role of Wnt5a as an inflammatory mediator in vivo., Data show that epigenetic disruption of WNT5A would contribute directly to the aberrant activation of WNT/beta-catenin signaling during ESCC pathogenesis., Data found that Wnt5a reduces cell surface levels and promotes ubiquitination and degradation of SDC4., In melanoma cells, expressions of Wnt5A and Klotho are inversely correlated., Results suggest that Wnt5a plays the role of a tumor suppressor in leukemogenesis through the Wnt5a/Ror2 noncanonical signaling pathway that inhibits Wnt canonical signaling., Hypermethylation of WNT5a is associated with colon cancer., WNT5A can act as a suppressor factor in leukemogenesis and can be used as a potential marker for curative effect assessment in leukaemia., Wnt-5a is not only a prognostic factor but also a therapeutic target molecule in gliomas for preventing tumor cell infiltration., PIK3CA mutation and the Wnt pathway have roles in ERalpha-positive breast cancer, Wnt5a plays an important role in regulating chemosensitivity to anticancer drugs in ovarian cancer cells, Data indicate that macrophages alter adipogenesis of 3T3-L1 cells not only via classical proinflammatory cytokines, but also via wnt signalling molecules., Results show expression of Wnt5a and Ror2 is induced during Snail-mediated epithelial-mesenchymal transition or malignant progression of cancer cells and that activated Wnt5a-Ror2 signaling confers highly motile and invasive properties on cancer cells., Several members of the WNT pathway, including WNT5A, FZD5, and DKK1 were highly up-regulated in PCa tissue from patients with advanced PCa., The loss of Wnt-5 may indicate the invasiveness of extramammary Paget's disease., The expression of Wnt5A is significantly increased in chronic rhinosinusitis with nasal polyps compared with controls., Wnt5a plays an important role in human hindgut and anorectal morphogenesis., Wnt5a was prominently expressed in human primary cytotrophoblast cells, but absent in the human choriocarcinoma cell line JAR., Wnt5a methylation was strongly associated with tumour microsatellite instability tumours after adjustment for age, sex, and tumour location, The expression of Wnt5a in the termina1 rectum decreases in children with anorectal malformation (ARM), suggesting Wnt5a may play an important role in the development of ARM., loss of Wnt5a predicts poor outcome in Epithelial ovarian cancer patients and Wnt5a suppresses the growth of cancer cells by triggering cellular senescence, GPC6 promotes invasive migration by inhibition of canonical beta-catenin and Wnt signalling, and up-regulation of non-canonical Wnt5A signalling leading to the activation of JNK and p38 MAPK., under high levels of Wnt5a monocytes could differentiate into unconventional dendritic cells with tolerogenic features., Differentiation paralleled the activation of Wnt5/Calmodulin signalling by autocrine/paracrine intense secretion of Wnt5a and Wnt5b, finding together with our in vitro data demonstrating the ability of Wnt5a to impair the invasive properties of prostate cancer cells, suggests a tumor suppressing effect of Wnt5a in localized prostate cancer, Data suggest that an anti-Wnt5a antibody was capable of suppressing Wnt5a-dependent internalization of Fz2 receptor, resulting in the prevention of metastasis of gastric cancer cells by inhibiting the activation of Rac1 and the expression of laminin gamma2., Wnt5a is secreted by follicular dendritic cells to protect germinal center B cells via Wnt/Ca2+/NFAT/NF-kappaB-B cell lymphoma 6 signaling., Wnt5a-Ror2 signaling might also be required for expression of MMP-13 gene during the development of the cartilaginous tissue., study underlines the critical role of BMSC-derived WNT5A in the regulation of inflammatory processes and suggests its participation in the pathogenesis of rheumatoid arthritis, WNT-5a and ROR2 were more highly expressed in more severe disease states, and therefore may play a coordinated role in the occurrence and progression of osteosarcoma, Wnt5a signalling contributes to tissue invasion by non-melanoma skin cancer, Pro-inflammatory wnt5a and anti-inflammatory sFRP5 are differentially regulated by nutritional factors in obese human subjects, Modulation of Wnt5a expression by P. gingivalis may play an important role in the periodontal inflammatory process., Data suggest that Wnt5a and Ror2 may serve as tumor suppressor genes in the development of hepatocellular carcinoma, and may serve as clinicopathologic biomarkers for prognosis in HCC patients., Under proinflammatory conditions the noncanonical Wnt protein Wnt5a induces immunosuppressive macrophages from malignant epithelial cells and in association with tumor-associated macrophages., Identification of a novel Wnt5a-CK1varepsilon-Dvl2-Plk1-mediated primary cilia disassembly pathway., Wnt5a promotes breast cancer cell migration via Dvl2/Daam1/RhoA., Wnt-5a and CYR61 are enriched in the extracellular matrix of liver fibrotic tissue compared with control matrix., High wnt5a expression is involved in the pathophysiology of Multiple myeloma-induced bone disease., These results suggest that Wnt5a signaling positions ESCRT-III in the midbody properly for abscission by stabilizing midbody microtubules, EBV-positive gastric carcinoma had no or very low expression of WNT5A but a high level of methylation in the promoter region., Data indicate that Wnt5a promoters, A and B, are differentially regulated and a model for complex transcriptional regulation of Wnt5a., findings suggest that epithelium-derived SFRP5 may play a probable defensive role in impeding gastric cancer progression, characteristically by inhibiting GEC migration induced by macrophage-derived Wnt5a via JNK signaling activation, Data indicate that Wnt5a mRNA level was correlated positively with CXCR4 mRNA level in Ewing sarcoma (ES) specimens., Wnt5a, APC and beta-catenin genes might be involved in the carcinogenesis and development of colorectal adenocarcinoma. It is hypothesized that down-regulation of APC and Wnt5a proteins may be one of causes of ectopic expression of beta-catenin in CRC., WNT5A was more frequently methylated in early stage gastric carcinomas., WNT-5A signaling is activated by and necessary for TGF-beta-induced extracellular matrix production by airway smooth muscle cells, determined if mutations in WNT5A contributed to the etiology of Mullerian duct abnormalities in 189 Chinese women, Wnt5a may be potentially involved in the effects of inflammation on bone formation., Data indicate changed ecpression levels of PRM2, HSP90 and WNT5A in male of couples experiencing idiopathic recurrent miscarriages., This study demonstrated the first attempt to identify Wnt5a and Ror2 as additional mechanisms contributing to dysregulation of the non-canonical WNT signaling pathway in medulloblastoma. Ror2 may play a role as an oncosuppressor in medulloblastoma., Wnt5a can be used as a predictive biomarker, and favoring the view of Wnt5a as a future therapeutic target in prostate cancer patients with tumor cells displaying low expression of Wnt5a., crucial role of Wnt5a in the smoking-related lung carcinogenesis, Wnt5a promotes breast cancer cell migration via the Dvl2/Rab35/Rac1 signaling pathway., Both WNT5A and NFATc2 proteins are highly expressed in human pancreatic cancer tissues., Wnt-induced dishevelled 2 phosphorylation has effects in in canonical and noncanonical Wnt3a and Wnt5a signaling, Loss of WNT5A expression due to methylation is related to aggressiveness of sporadic breast cancer., ARF6 may provide a means of inhibiting WNT/beta-catenin signaling in cancer, Our results do not support the relevance of ROR2/Wnt5a as biomarkers in stage 1 pure seminomas, WNT5A inhibits metastasis and alters splicing of Cd44 in breast cancer cells., WNT5A may play an important role in constructing an advantageous tumor microenvironment for the progression and development of human gastric cancer., Plasma Wnt5a levels are decreased in patient with type 2 diabetes mellitus., Our results suggest that Wnt5a is a major contributing factor to the increase in osteolytic bone lesions and hypercalcemia found in Adult T-cell leukemia/lymphoma patients, Wnt5a inhibits human monocyte-derived myeloid dendritic cell generation., Inhibition of Wnt5a by either RNAi knockdown or blocking antibody reversed Smarcd3 -induced epithelial-mesenchymal transition. Thus, Smarcd3 epigenetically regulates epithelial-mesenchymal transition by activating WNT signaling pathways., Wnt5a signaling pathway may be involved in the malignancy of glioma., High WNT5A expression is associated with colon cancer., Wnt5a pathway may play a role in the pathogenesis of urothelial carcinoma of the bladder., DEX induces the upregulation of noncanonical Wnt ligand Wnt5a. Recombinant WNT5a protein induces CLAN formation through the noncanonical Wnt receptor ROR2/RhoA/ROCK signaling axis., Wnt5a assembles a Wnt-receptor-actin-myosin-polarity structure and directs polarized calcium gradients., It plays a important role in pathogenecity of frontotemporal lobar degeneration, which suggests a novel target for the therapeutic intervenion., Upregulation of Wnt5a promotes EMT and metastasis in pancreatic cancer models., MV and exosomes are critical for MPhi-induced invasion of cancer cells since they are responsible for upregulation of MPhi-Wnt 5a as well as for its delivery to the recipient cells via a reciprocal loop., our study provides evidence that the distinct activities of WNT5A in cancer can be attributed to the production of two WNT5A isoforms., findings support a new role for WNT5A in the metabolic reprogramming of cancer cells that is a context- dependent event, Wnt5a uses CD146 as a receptor to regulate cell migration., Wnt5a, TLR2 and TLR4 are elevated in advanced human atherosclerotic lesions., Wnt5a signals in hCMEC/D3 cells through activation of the Par/aPKC PCP complex, independently of the Wnt canonical beta-catenin-dependent pathway and significantly contributes to TJ integrity and endothelial apicobasal polarity., The expression levels of Wnt5a, p-JNK1 and p-paxillin in tumor tissues were correlated with each other., Ursolic acid suppressed the expression of Wnt5alpha/beta and beta-catenin, inducing apoptosis in prostate cancer cells., Wnt5a overproduction and SFRP5 deficiency in gastric mucosa may together play an important role in gastric inflammation and carcinogenesis., Our findings indicate that Wnt5a might act as tumor suppressor by inhibiting cell proliferation and attenuating EMT in colon cancer cells, WNT5A derived from bone stromal cells induced the expression of BMP-6 by CaP cells; BMP-6 in turn stimulated cellular proliferation of CaP cells., SFRP5 and WNT5A comprise a balanced duo that may regulate metabolic homeostasis in prepubertal children., differential Wnt11 immunoexpression in high-grade human serous ovarian cancer compared to low-grade human serous ovarian cancer could play important roles in serous ovarian cancer progression and may be modulated by Wnt5a expression levels., The Wnt-5a was expressed and correlated with cell motility and infiltrative activity through the regulation of matrix metalloproteinase (MMP)-2 in glioma-derived cells., Results reveal pro-tumorigenic effects of WNT5A in nasopharyngeal carcinoma., Data show that the WNT/beta-CATENIN signaling cascade components, including WNT ligands WNT3 and WNT5A, is crucial for early odontogenesis., establish a directional crosstalk between calcium-sensing receptor and Wnt/beta-catenin signaling in keratinocyte differentiation via Wnt5a that acts as an autocrine stimulus in this process, Wnt5a may act as a tumor-suppressor gene in hepatocellular carcinoma, we demonstrate that innate immune functions of macrophages ensue at least partly through a homeostatic Wnt5a-Fz5-NF-kappaB (p65) circuit, which is Rac1 dependent., De novo WNT5A-associated autosomal dominant Robinow syndrome suggests specificity of genotype and phenotype., Our study suggests that wnt5a may play a role in the pathophysiology of psoriasis and its metabolic comorbidity such as insulin resistance., WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells., Data indicate that cell migration was inhibited in Wnt5a-inhibited melanoma cells., WIF-1 is frequently methylated and that Wnt5a acts as a tumor suppressor gene in colorectal carcinoma., Activation of noncanonical Wnt signaling through the up-regulation of WNT5A may promote a proinflammatory state in visceral adipose tissue contributing to the development of obesity-associated comorbidities., RNAi-mediated reduction of endogenous WNT5A in melanoma decreased cell growth, increased apoptosis in response to BRAF inhibitor challenge, and decreased the activity of prosurvival AKT signaling., data suggest that Wnt5a, as an inflammatory mediator that drives the integration of cytokines and chemokines, acts downstream of TNF-alpha., Results show that Wnt5a promoted epithelial-mesenchymal transition via PKCalpha in epithelial ovarian cancer., the findings suggested that miR-26a may function as a tumor suppressor in prostate cancer by targeting Wnt5a., The results demonstrate that Wnt5a induces monocyte chemotactic protein 1 production in gastric cancer, which is mediated by IL-1beta., The results demonstrated that overexpression of Wnt5a may play an important role in NSCLC angiogenesis and it may function via canonical Wnt signal pathway., Findings suggest that Wnt5a enhances cell migration through activation of Cdc42 and inactivation of RhoA in human corneal endothelial cells., Wnt-5a mRNA levels were significantly higher in hepatocellular carcinoma tissue than in the para-carcinoma tissue while Wnt-5a protein was absent or low, Aberrant methylation of APC gene was statistically significant associated with age over 50, DDK3 with male, SFRP4, WIF1, and WNT5a with increasing tumor stage SFRP4 and WIF1 with tumor differentiation and SFRP2 and SFRP5 with histological type, Wnt5a signaling increases IL-12 secretion by human dendritic cells and enhances IFN-gamma production by CD4+ T cells., This study thus provides evidence that the ability of WNT5A to promote cancer progression is dependent on the cellular context., WNT5A exhibits antitumor effects in prostate cancer cells and may be suitable as a prognostic marker and therapeutic target for prostate cancer and associated skeletal metastases, Wnt5a secreted by monocytes signals through the noncanonical Wnt-FZD5 pathway in mECs to induce TF expression that induces angiogenesis by autocrine regulation., Wnt5a has a role in the pathogenesis of atherosclerosis and other inflammatory disorders [review], WNT5a acts as a proinflammatory factor in human ovarian granulosa cells. The up-regulated expression of WNT5a in PCOS increases inflammation and oxidative stress predominantly via the phosphatidylinositol 3-kinase/AKT/NF-kappaB signaling pathway., WNT5A induced chemoresistance by regulation of G1-S transition in pancreatic cancer cells., Upregulation of Wnt5A was associated with metastasis and progression of cervical cancer., The wnt5a/sFRP5 system is altered in human sepsis and might therefore be of interest for future studies on molecular pathophysiology of this common human disease., the Wnt5A signaling pathway was shown to contribute to regulating the drug-resistance protein ABCB1 and beta-catenin-related genes in antagonizing the toxic effects of doxorubicin in cell lines and in clinical breast cancer samples., These data point to Wnt5A as a master regulator of an adaptive stress response in melanoma, which may contribute to therapy resistance., In gastric cancer, HNF4alpha regulated WNT signalling through its target gene WNT5A., Serum wnt5a gene expression might be a potential biomarker for predicting the prognosis of acute on chronic hepatitis B liver failure., The Wnt5a/Ca 2+ /calcineurin/nuclear factor of the activated T signaling pathway in melanoma., Human placenta-derived Wnt-5a induces the expression of ICAM-1 and VCAM-1 in CD133(+)CD34(+)-hematopoietic progenitor cells., Wnt5a-Ror2 axis is constitutively activated in cancer cells and confers highly motile and invasive properties on cancer cells through the expression of matrix metalloproteinase genes and enhanced formation of invadopodia., Wnt5a activated Src family kinases (SFKs) and Wnt5a-dependent cancer cell proliferation was dependent on SFKs, yet blockade of receptor-mediated endocytosis did not affect cancer cell proliferation and SFK activity., These results suggest that Wnt5a expressed in PDL tissue plays specific roles in inducing collagen production by PDL cells through TGFbeta1-mediated upregulation of periostin expression., Heterozygous loss of WNT5A was correlated with shorter survival of breast cancer patients., Loss of WIF1 enhances the migratory potential of glioblastoma through WNT5A that activates the WNT/Ca(2+) pathway and MALAT1., Wnt5a is a potential suppressor of EMT; there is a novel Arf6/ERK signaling pathway for EGF-regulated Wnt5a expression at transcriptional level of gastric cancer cel, Data suggest that WNT5A is an important molecule in promoting stem cell characteristics in NPC, leading to tumorigenesis and metastasis., Osteogenic features of MSCs from ossification of yellow ligament patients are promoted by unmethylated WNT5A., results provide evidence that Wnt5a induces protein depalmitoylation, which promotes polarized protein localization and cell invasion., miR-217 functions as a tumor suppressor in osteosarcoma by suppressing Wnt5a expression., in hepatic stellate cells regulates inflammatory cytokine and collagen production and cell proliferation, independent of the canonical Wnt signaling pathway, Knockdown of Wnt5a suppresses the proliferation of keratinocytes and induces apoptosis by inhibiting the Wnt/beta-catenin or Wnt5a/Ca(2+) pathways, The homozygous genotypes (CC for rs524153 and GG for rs504849) were associated with a lower WNT5A transcriptional level compared with the transcriptional level of those with wild-type genotypes., It is involved in tumor initiation, cancer stem cell maintenance and angiogenesis., Findings suggest that high receptor tyrosine kinase-like orphan receptor (ROR) 2 or proto-oncogene protein Wnt-5A (Wnt5a) expression is associated with poor prognosis in non-small cell lung cancer (NSCLC)., Data show that the WIF domain of Wnt Inhibitory Factor 1 (WIF1) is bound by C-terminal domains of Wnt proteins Wnt5a and Wnt7a at two sites., The results reveal higher WNT-5A protein levels and mRNA expression in a subgroup of gliomas compared to non-malignant control brain tissue. It also showes a significant correlation between WNT-5A in the tumor and presence of microglia/monocytes., WNT-5A is a crucial signaling molecule under investigation with efforts to not only delineate its signaling mechanisms and functions in physiological and pathological conditions, but also to develop strategies for its therapeutic targeting. [review], Forced overexpression of Wnt7B with or without TGFB1 treatment increased Wnt5A protein expression in normal human smooth muscle cells and fibroblasts but not in Idiopathic Pulmonary Fibrosis myofibroblasts where Wnt5A was already highly expressed., WNT5A participates in the biology of odontogenic tumors and inflammatory cyst but not in developmental cyst., results corroborated previous findings of Ryk-mediated Wnt5a effect, and suggested a role for Ror2 in the Wnt5a machinery in glioblastoma, This study identifies an interaction between ROR1 and ROR2 that is required for Wnt5a signaling that promotes leukemia chemotaxis and proliferation., Wnt5a-Ror2 signaling enhances expression and secretion of CXCL16 in mesenchymal stem cells thereby activating CXCR6 expressed on tumor cells to promote proliferation., Mutation in WNT5A may serve as a susceptibility factor for Congenital Anomalies Of Kidney And Urinary Tract., Noncanonical Wnt5a signaling and JNK activity contribute to vascular insulin resistance and endothelial dysfunction., Epigenetic inactivation of the WNT5A promoter B involves both DNA methylation and histone modifications. Differential expression of the WNT5A alternative promoters A and B is a characteristic of osteosarcomas., Wnt5a is increased and beta-catenin is decreased in parenchyma from idiopathic pulmonary fibrosis patients.,
OMIM_DISEASE Robinow syndrome, autosomal dominant 1,
SP_COMMENT function:Ligand for members of the frizzled family of seven transmembrane receptors., function:Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes., PTM:Glycosylation is necessary for secretion but not for activity., PTM:Palmitoylation is necessary for stimulation of cell migration, inhibition of the beta-catenin pathway and receptor binding., similarity:Belongs to the Wnt family., subunit:Interacts with PORCN., tissue specificity:Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level).,