Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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Wnt family member 3(WNT3) Wnt family member 3(WNT3) Related Genes Homo sapiens
GENERIF_SUMMARY Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45, Wnt3 plays an important role in regulating characteristics and activity of stromal cells., The Wnt-3a triggers the interaction of LRP6 with caveolin and promotes recruitment of Axin to LRP6 phosphorylated by glycogen synthase kinase-3beta and that caveolin thereby inhibits the binding of beta-catenin to Axin., an internally truncated LRP5 receptor is strongly implicated in deregulated activation of the WNT/beta-catenin signaling pathway in hyperparathyroid tumors, The results indicated that HBx induction in the CCL13-HBx stable cell line downregulated Wnt-3/beta-catenin expression and suppressed cell growth by repressing cell proliferation or triggering cell apoptosis., a functional interaction between Wnt3 and FZD7 leading to activation of the Wnt/beta-catenin signaling pathway in HCC cells and may play a role during hepatocarcinogenesis., CTLA-4 is a direct target of Wnt/beta-catenin signaling and is expressed in human melanoma tumors, WNT3 regulates distinct internalization pathways of LRP6 to tune the activation of beta catenin signaling., mantle cell lymphoma highly and consistently expressed Wnt3 and Wnt10., WNT activity regulates the self-renewal of prostate cancer cells with stem cell characteristics independently of androgen receptor activity., RNA samples from 21 neuroblastoma showed a highly significant FZD1 and/or MDR1 overexpression after treatment, underlining a role for FZD1-mediated Wnt/beta-catenin pathway in clinical chemoresistance., Results demonstrated significant up-regulation of WNT-3, WNT-4, WNT-5B, WNT-7B, WNT-9A, WNT-10A, and WNT-16B in patients with CLL compared to normal subjects., Abnormalities of the Wnt3/3a pathway (located in the apical ectodermal ridge) include tetra-amelia and loss of the distal phalanges/nails., Individuals carrying variant alleles in WNT3 presented an increased risk for cleft lip/palate (p = 0.0003; OR, 1.61; 95% CI, 1.29-2.02) in the Brazilian population studied., Extracellular domain of FZD7 (sFZD7) was tested for its functional activity to interact with Wnt3, its ability to inhibit Wnt3-mediated signaling., SNP rs415430 in the WNT3 gene was not associated with the risk of development of Parkinson disease, The apoptotic index was significantly lower in high-Wnt3 tumors than in low-Wnt3 tumors (P=0.0245)., The findings of a significant association between lip and/or palate clefts and two markers in the WNT3 and COL11A2 genes were the most consistent and were observed in all groups analysed and stratified., study confirmed the involvement of polymorphisms in the WNT3 gene in NCL/P aetiology in the tested population., Knockdown of Wnt3 by siRNA restored cytoplasmic expression of beta-catenin., mRNA level of WNT3 in hESCs correlates with their definitive ectoderm differentiation efficiency., Colorectal tumors express elevated levels of Wnt3 and GPR177., WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation., WNT3 and WNT5B are critical factors, secreted from mesenchymal cancer cells, for instigating the epithelial cancer cell invasion., Data show that the WNT/beta-CATENIN signaling cascade components, including WNT ligands WNT3 and WNT5A, is crucial for early odontogenesis., Genome association study shows a highly conserved 32 kb intergenic region containing regulatory elements between WNT3 and WNT9B in patients with classic bladder exstrophy., WNT3 involvement in human bladder exstrophy and cloaca development in zebrafish, WNT3 and membrane-associated beta-catenin regulate trophectoderm lineage differentiation in human blastocysts., Two SNPs (rs3809857 and rs9890413) in the WNT3 gene were subjected to case-control and case-parent analysis,
OMIM_DISEASE Tetra-amelia syndrome,
SP_COMMENT disease:Defects in WNT3 are the cause of autosomal recessive tetra-amelia [MIM:273395]. Tetra-amelia is a rare human genetic disorder characterized by complete absence of all four limbs and other anomalies such as craniofacial, nervous system, pulmonary, skeletal and urogenital defects., function:Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube., similarity:Belongs to the Wnt family., subunit:Interacts with PORCN.,