Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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Wnt family member 2(WNT2) Wnt family member 2(WNT2) Related Genes Homo sapiens
CYTOBAND 7q31.2,
GENERIF_SUMMARY Up-regulation of WNT2 mRNA by estrogen might play a key role in some cases of human breast cancer through activation of the beta-catenin - TCF signaling pathway., Activating mutations of the WNT2 gene are not a major contributor to the development of autistic disorder., REVIEW, Our interpretation of these findings is that it is unlikely that DNA variations in RELN and WNT2 play a significant role in the genetic predisposition to autism., Target genes involved in tumor WNT pathways in response to TGF-beta1 were found in cervix cancer cells., Wnt/beta-catenin signalling pathway is activated in most of gastric cancers, which may play pivotal roles either in gastric cancer formation or in tumour invasion and dissemination, Inhibition of Wnt2 by monoclonal antibodies is of therapeutic interest in the development of more effective treatments for malignnt pleueral mesothelioma., The increased Wnt2 expression in gastric cancers is paralleled with reduction of membranous E-cadherin., The WNT2 gene is upregulated along the progression from low-grade dysplasia to esophageal adenocarcioma., Regulation of Fz4 expression by Wnt2., inhibition of both Wnt-2 and Gal-3 had synergistic effects on suppressing canonical Wnt signaling and inducing apoptosis, suggesting that aberrant canonical Wnt/beta-catenin signaling in colorectal cancer can be regulated at multiple levels, potential coordinative effects of Wnt, NF-kappaB and/or Stat3 activation on gastric cancer formation presumably by promoting the transcription of their common target genes., Persistent upregulation in colorectal carcinoma cases studied., Wnt (Wnt2), Stat3, and Notch-1 and -2 signaling are correlated in human epidermal tumors., Knockdown of Wnt2 by siRNA in human U251 glioma cells inhibited cell proliferation and invasive ability, and induced apoptotic cell death, The results suggest that WNT2 could act through its receptor FZD9 to regulate the beta-CATENIN pathway in cumulus cells, recruiting beta-CATENIN into plasma membranes and promoting the formation of adherens junctions involving CDH1., up-regulation of the Wnt-2 protein might play a role in the development of colorectal cancers., RNA samples from 21 neuroblastoma showed a highly significant FZD1 and/or MDR1 overexpression after treatment, underlining a role for FZD1-mediated Wnt/beta-catenin pathway in clinical chemoresistance., Wnt2 acts as an angiogenic factor for non-sinusoidal endothelium in vitro and in vivo., These data demonstrate that mesenchymal stem cells from mice and humans produce Wnt proteins and TGF-beta1 that respectively stimulate lung fibroblast proliferation and matrix production., Wnt2/beta-catenin signaling pathway is constitutively activated in esophageal squamous cell carcinoma (ESCC) cells, indicating that Wnt2/beta-catenin pathway plays an essential role in carcinogenesis of the esophagus., findings provide evidence for a significant association between WNT2 and autism., The present study does not support a major role for WNT2 in schizophrenia., DNA methylation within the WNT2 promoter in human placenta is associated with low birthweight., a haplotype of WNT2 (rs2896218-rs6950765, Wnt/beta-catenin pathway forms a negative feedback loop during TGF-beta1 induced human normal skin fibroblast-to-myofibroblast transition, significant association with SNP rs4730775 locus on chromosome 7 with genetic susceptibility to Peyronie's disease, The WNT2 gene may play a suggestive role in language development in autistic disorder., Expression of WNT2 in pancreatic cancer cells suppresses anoikis, enhances anchorage-independent sphere formation, and increases metastatic propensity in vivo., Pdgf signaling potentiates Wnt2-Wnt7b signaling to promote high levels of Wnt activity in mesenchymal progenitors that is required for proper development of endoderm-derived organs, such as the lung, The skin lesions of scleroderma patients showed obviously increased expression of cytoplasmic Wnt 2, nuclear Wnt 3a and beta-catenin, but markedly lowered cell membrane expression of beta-catenin than normal skin., Decreased placental expression of Wnt2 and increased placental expression of sFRP4 may be associated with the pathogenesis of severe preeclampsia., The study demonistrated that expressions of Wnt-2 in high-grade brainstem gliomas were significantly higher than that in low-grade brainstem gliomas and normal brain tissues and were positively correlated with the expression of Ki-67., Hypermethylation of WNT2 is associated with colorectal cancer., We demonstrated an activation of Wnt-2 signaling via the Frizzled-8 receptor in non-small cell lung cancer cells, High expression of Wnt2 is associated with pancreatic cancer progression promoted by pancreatic stellate cells., Wnt2/beta-catenin signaling was involved in stromal-epithelial cells interaction in endometriosis., Wnt2 complements Wnt/beta-catenin signaling in regulating colorectal cancer cell proliferation.,
SP_COMMENT function:Ligand for members of the frizzled family of seven transmembrane receptors., function:Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters., similarity:Belongs to the Wnt family., tissue specificity:Expressed in brain in the thalamus, in fetal and adult lung and in placenta.,