Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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Wnt family member 1(WNT1) Wnt family member 1(WNT1) Related Genes Homo sapiens
GENERIF_SUMMARY Wnt-1 but not epidermal growth factor induces beta-catenin/T-cell factor-dependent transcription in esophageal cancer cells., Synergistic induction of tumor antigens by Wnt-1 signaling and retinoic acid revealed by gene expression profiling, The potential role of the WNT-1 gene in basal cell carcinoma seems to correlate with its ability to induce elevated cytoplasmic beta-catenin levels., Data show that Wnt-1 induces expression of antiapoptotic genes in 3T3-L1 preadipocytes such as IGF-I and IGF-II, which allows these cells to resist apoptosis in response to serum deprivation., Role of Wnt pathway in medulloblastoma oncogenesis, Wnt signaling has a role in endothelial cell growth control and this is mediated through cell-cell contact, Wnt signal transduction through the Tak1 pathway phosphorylates and inhibits TCF, which might function as a feedback mechanism, CTNNB strongly increased activity of the eN/Nt5 promoter and this increase depended on the presence of TCF-1; demonstrated a link between Wnt signaling and the regulation of eN and ADA, which control the metabolism of adenosine, Wnt regulation of the Lef-1 promoter at the WRE may play an important role during airway submucosal glandular bud formation., Oncogenic activation of the WNT/beta-catenin signaling pathway is common in hepatocellular carcinoma., Causal relationship exists between aberrant Wnt-1 signaling and estrogen receptor+ mammary tumors, HCV core protein induces Huh-7 cell proliferation whether alone or in the context of HCV replication, which is at least partly mediated by transcriptional upregulation of growth-related genes, in particular wnt-1, Wnt-1 blockade by either monoclonal antibody or siRNA induces cell death in sarcoma cells, Wnt-1, beta-catenin and APC expressions were related to the differentiation of oral squamous cell carcinoma., aberrant Wnt signaling is a common event in NPC carcinogenesis linked with WIF-1 silencing, hAR is a direct target of LEF-1/TCF transcriptional regulation in PCa cells; expression of the hAR protein is suppressed by a degradation pathway regulated by cross-talk of Wnt, Akt, and PP2A, EGCG blocks Wnt signaling by inducing the HBP1 transcriptional repressor and inhibits aspects of invasive breast cancer, increased Wnt signaling, as achieved by ectopic expression of Wnt-1, triggers the DNA damage response and an ensuing cascade of events resulting in tumorigenic conversion of primary breast epithelial cells, the MED12 interface within Mediator is a new component in the Wnt/beta-catenin pathway, Wnt/beta-catenin activation was observed in 65% of pancreatic adenocarcinomas, independently of beta-catenin gene mutations in most tumors, beta-catenin level depends on the way and level of Wnt pathway activation, Wnt signaling activation significantly decreases the viability of retinoblastoma cell lines by inducing cell cycle arrest, which was associated with upregulated p53, sFRP-1, a target gene of the hedgehog pathway, is involved in cross-talk between the hedgehog pathway and the Wnt pathway, The identification of a beta-catenin-T-cell factor-regulated Axin2-GSK3beta-Snail1 axis provides new mechanistic insights into cancer-associated epithelial-mesenchymal transition programmes., Wnt/beta-catenin signaling has a role in neurodevelopment as well as in neurodegenerative diseases [review], Wnt1 is critical for protection in the SH-SY5Y neuronal cell line against genomic DNA degradation, membrane phosphatidylserine (PS) exposure, and microglial activation., Wnt1 signaling inhibits interfollicular progenitor cell growth and promotes terminal differentiation of keratinocytes., importance of canonical Wnt signaling to mediate development of early hematoendothelial progenitors during human development, Wnt and epidermal growth factor receptor signaling pathways are altered through aberrant methylation and mutation in non small cell lung cancer, vascular Bmp Msx2 Wnt signaling and oxidative stress have roles in arterial calcification [review], Silencing of WNT1 by siRNA induces apoptosis of MCF-7 human breast cancer cells., Wnt1 overexpression affects the tumor proliferation in NSCLCs, partly via the upregulation of c-Myc, Wnt-1 strongly induced the expression of matricellular protein osteopontin, and modestly enhanced the expression of type I collagen in DPSCs. Unexpectedly, Wnt-1 inhibited alkaline phosphatase activity and the formation of mineralized nodules in DPSCs., MesP1 drives vertebrate cardiovascular differentiation through Dkk-1-mediated blockade of Wnt-signalling, direct binding of NF-kappaB-p50 to the Wnt-1 promoter, A positive feedback stimulation of the Wnt pathway by activation of snail., HIF-1alpha was found to inactivate the Wnt signaling by binding to hARD1 or beta-catenin, which may contribute to the hypoxia-induced growth arrest of tumor cells., the Wnt/beta-catenin pathway contributes to carcinogenesis and cancer cell survival by driving expression of OPG, In the gastric cancerous tissues, the expression percentage of Wnt-1, beta-catenin and E-cadherin is 54.4%, 45.6%, 47.2%, respectively, which is significantly higher than the percentage expression of these genes in normal tissues (p<0.01)., RCK/ p54 might be a determinant of colorectal cancer proliferation by activating the canonical Wnt pathway, HDAC3 overexpression alters the epigenetic programming of colon cancer cells to impact intracellular Wnt signaling and their sensitivity to external growth regulation by vitamin D, The Wnt1 overexpression is associated with the expression of tumour-associated Wnt-targets, tumour proliferation, angiogenesis and a poor prognosis in NSCLCs., ER stress causes dissociation between GRP78/BiP and Wnt, an interaction essential for its correct posttranslational processing, propose that cytoplasmic stabilization of beta-catenin through palmitoylation of Wnt-1 and subsequent activation of the pathway is a potential mechanism of FASN oncogenicity in prostate cancer, adenomatous polyposis coli gene and nuclear b-catenin may have roles in wnt-related progression of invasive urothelial carcinomas, Dpr1 negatively modulates the basal activity of Wnt1/beta-catenin signaling in the nucleus by keeping LEF1 in the repressive state., analysis of Wnt/beta-catenin and Myc signaling in liver cancer, WNT1 was overexpressed in ovarian carcinoma, Wnt1 and Wnt signaling have an important role in human mesenchymal stem cell osteogenesis., the 3' untranslated regions of WNT1 and JAG1 were functional targets of miR-34a and miR-21 and provide evidence that these targets were translationally suppressed, Activation of Wnt/beta-catenin signalling pathway induces chemoresistance to IFN-alpha/5-FU therapy., Wnt/beta-catenin signaling pathway may be activated abnormally in some nasopharyngeal carcinoma (NPC) patients. beta-catenin may be a prognostic factor of NPC., WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth, Ectopic expression of either Wnt1 or stabilized beta-catenin in vitro induced the transcription factor Snail and suppressed nephrin expression, leading to podocyte dysfunction, CDK5-splicing variant might also be a negative regulator of Wnt/beta-catenin signaling pathway., PPP(S/T)P motif phosphorylation of the free LRP6 intracellular domain is not required to activate the Wnt/beta-catenin pathway and attenuate GSK3beta activity, HMGA1 is involved in proliferation and gastric tumor formation via the Wnt/beta-catenin pathway., These data demonstrate that mesenchymal stem cells from mice and humans produce Wnt proteins and TGF-beta1 that respectively stimulate lung fibroblast proliferation and matrix production., Activated embryonal development-related wnt1/beta-catenin pathway might take part in the oncogenesis and growth of neural crest-derived neuroblastoma., Results suggest that the blockade of Wnt-1-mediated signaling may offer a potential pathway-specific therapeutic strategy for the treatment of a subgroup of HCC that over-expresses Wnt-1., SALL4 plays a critical role in the pathogenesis of MDS by causing the aberrant activation of the Wnt/beta-catenin pathway., procaine and procainamide reactivate WIF-1 in lung cancer cells and downregulate the Wnt canonical pathway, the beta-catenin-dependent Wnt pathway is integrated with integrin signaling through the adaptor molecule Grb2, Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling, activation of the Wnt pathway is associated with high proliferation, dedifferentiation and a solid morphology in biliary tract cancer, the WIF-1 gene is frequently down-regulated or silenced in astrocytomas by aberrant promoter methylation, Overexpression of Wnt1/beta-catenin might predict the clinicopathologic stage and prognosis of esophageal squamous cell carcinoma (ESCC) and the level of Wnt1/beta-catenin mRNA was conversely correlated with lymph node metastasis and advanced disease., Data indicate involvement of canonical Wnt signaling and link between the Wnt pathway and chromatin regulation in epithelial stem cells., Intratumoral Wnt1 overexpression could produce more aggressive NSCLCs by induction of survivin., The protein expression levels of Wnt1, beta-catenin and Cyclin D1 were all positively correlated with the Karnofsky performance scale (KPS) score and World Health Organization (WHO) grades of patients with gliomas., Wnt-1 regulates IL-1beta-mediated HIF-1alpha induction via NF-kappaB., TMEM88 associates with Dvl proteins and regulates Wnt signaling in a context-dependent manner, the aim of this study was to investigate the prognosis and clinicopathologic roles of beta-catenin, Wnt1, Smad4, Hoxa9, and Bmi-1 in esophageal squamous cell carcinoma, Novel insights into roles for DKK1 in addition to canonical WNT signaling and the mechanism of colon cancer initiating cells transformation., These findings demonstrate that Wnt1 is a novel angiogenic protein that is expressed in developing endothelial cells and can be therapeutically deployed to increase blood flow and angiogenesis., High Wnt1 is associated with non-small cell lung cancer after surgery., WNT1 and SFRP1 mRNA levels were higher in DU145 cells compared to non-osteotropic cells., PDE5 inhibition by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/beta-catenin-mediated transcription in human breast tumor cells, Abnormal expression of E-cadherin, beta-catenin, Wnt-1 was observed., BR-DIM and CDF inhibited the signal transduction in the AR/TMPRSS2-ERG/Wnt signaling network, leading to the inactivation of Wnt signaling consistent with inhibition of prostate cancer cell invasion, Data suggest that PL suppresses tumor growth, invasion, and angiogenesis through the inhibition of Wnt/beta-catenin signaling in certain colon cancer cells., Interplay of Wnt and c-MYC signaling during intestinal homeostasis and transformation., Data suggest that VDR controls the level of nuclear beta-catenin in colon cancer cells and can therefore attenuate the impact of oncogenic mutations that activate the Wnt/beta-catenin pathway., a connection between Wnt1 signaling and the transcriptional regulation of neurodegenerative disease genes, One mechanism through which canonical Wnt signaling could shape niches supportive of hematopoiesis., Studies indicate that pathways of Hedgehog (Hh), Wnt and Notch, which regulate development during embryonic life and somatic stem cells (SCs) in the adult organism, can be reactivated in malignancies and support tumor-initiating cells (TIC) scompartment., Data indicate that CDH11 as a functional tumor suppressor and an important antagonist of Wnt/beta-catenin signaling, with frequent epigenetic inactivation in common carcinomas., Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires beta-catenin activation via Akt/GSK3- and MTA1/Wnt1 protein-dependent pathways., Epigenetic silencing of sFRP1 activates the canonical Wnt pathway and contributes to increased cell growth and proliferation in hepatocellular carcinoma, Erythropoietin prevents beta-amyloid degeneration of microglia via Wnt1/PI 3-K/mTOR/Bad/Bcl-xL pathway., This study establishes an association between low Wnt-1 and high Dkk-1 serum levels and premature myocardial infarction, Wnt/beta-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4, Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/beta-catenin signaling, GSK3beta plays an essential role in Ras degradation and inhibition of this degradation pathway by aberrant Wnt/beta-catenin signaling may contribute to Ras-induced transformation in colorectal tumorigenesis, Studies idicate that NOTCH, BMP4 and WNT pathways are involved in the regulation of intestinal cancer stem cells., peptide derived from the loop 2 region of sclerostin blocked the interaction of sclerostin with LRP5/6 and also inhibited Wnt1 but not Wnt3A or Wnt9B signaling. This suggests that these Wnts interact with LRP6 in different ways, R-Spondin potentiates Wnt/beta-catenin signaling through orphan receptors LGR4 and LGR5, These results suggest, for the first time, that the Wnt/beta-catenin pathway regulates ABCB1 in CML., PDZ-RGS3 can enhance signals generated by the Wnt canonical pathway and plays a pivotal role in epithelial mesenchymal transition, Findings suggest that Mel-18 is a novel negative regulator of breast cancer stem cell (CSC) that inhibits the stem cell population and in vitro and in vivo self-renewal through the inactivation of Wnt-mediated Notch signaling., Psychiatric disorder-related behavioral abnormalities are displayed in a neural crest-derived brain region of WNT1/GAL4 double-transgenic mice., Matrix rigidity activates Wnt signaling through down-regulation of Dickkopf-1 protein, Promoter hypermethylation of WNT gene is associated with Basal Cell Carcinoma., Studies indicate that DISC1 and AKT were invlved in the regulation of GSK3beta and Wnt signaling paathway., Mutations in WNT1 are a cause of osteogenesis imperfecta., Mutations in WNT1 cause different forms of bone fragility., WNT1 mutations are associated with moderately severe and progressive recessive osteogenesis imperfecta., Wnt1 expression in invasive breast tumour cells seems to promote differentiation and apoptosis, while being related inversely to proliferation., Data indicate that the canonical Wnt/sscatenin signaling pathway appears to trigger amniotic fluid mesenchymal stem cells (huAFMSC) osteoblastogenesis., The Wnt1-beta-catenin pathway represses let-7 microRNA expression through transactivation of Lin28 to augment breast cancer stem cell expansion., This report identifies human skeletal diseases associated with mutations in WNT1., alterations of the Wnt1/beta-catenin axis in clear cell renal cell carcinoma (ccRCC) were examined., Wnt-1 is a target of regulation by miR-200b and miR-22., High WNT1 expression is associated with prostate cancer., A functional missense variant of WNT1 (rs61758378 resulting in S88R)was overrepresented in autism spectrum disorder patients. Functional analysis revealed that WNT1-S88R is more active than wild-type WNT1 in assays for the Wnt/beta-catenin signaling pathway., In human pancreatic mucinous cystic neoplasms, expression of Wnt1 was detected in focal cyst epithelial cells in the majority of cases. The ovarian-like stroma was diffusely positive for Wnt1 in all of the human MCN cases examined., Hypoxic macrophages impair autophagy in epithelial cells through Wnt1., FGFR1, WNT, and TGF-beta have roles in signaling of reactive stroma in aggressive prostate adenocarcinomas, Identify emilin2 as a key extracellular regulator of the Wnt signalling pathway suppressing breast cancer cell growth and migration., These findings provide important evidence that the reduced miR-152 expression by HCV core protein can indirectly lose an inhibitory effect on Wnt1, which might, at least partially lead to cell proliferation of liver cancer cells., Upregulation of WNT1 is associated with lung cancer invasion., Activation of Wnt1 and beta-catenin signaling accelerates the proliferation of gastric cancer stem cells., WNT/beta-catenin pathway and E-cadherin are important factors in advanced epithelial ovarian cancer., The expression levels of WNT1 was found to increase in both cancer stem cells and non- cancer stem cells when cancer stem cells were maintained as spheroids, Data indicate that BMVC- and BMVC4-repressed WNT1 gene expression through stabilizing the G-quadruplex structure formed at its promoter., Data indicate that miR-122 suppressed the activation of Wnt/beta-catenin pathway by targeting WNT1., Bisphosphonate treatment of children with WNT1 mutations was associated with increasing lumbar spine areal bone mineral density z-scores, but the effect was smaller than what had been reported for children with classical osteogenesis imperfecta., The immunofluorescent staining pattern of Wnt1 and CK7 as well as Wnt1 and CK13 was consistent with IHC results. Thus, in pleomorphic adenoma, Wnt is involved in tumor cell differentiation of peripheral columnar cells forming solid nests, Results suggest ivermectin as therapeutic WNT protein-TCF transcription factor pathway response blocker to treat WNT-TCF-dependent diseases including multiple cancers., Our study suggests that Sox9 siRNA inhibits the proliferation capability of human osteosarcoma cells by down-regulating the expression of Wnt1 and its receptor Fzd1, Paracrine WNT signaling is stimulated by estrogen and progesterone, while autocrine WNT signaling is induced by the embryonic T-box transcription factor TBX3, in the absence of retinoid signaling via RARbeta, reduced IGF-1 signaling results in suppression of epithelial-mesenchymal transition and delays tumorigenesis induced by the Wnt1 oncogene, Wnt1 stimulates osteogenic differentiation and mineralization of human periodontal ligament fibroblasts, mainly by activating the canonical Wnt/beta-catenin pathway, in which Runx2 is a key downstream regulator., WNT1 was a direct target of miR-148b, and overexpressed WNT1 inversely correlated with miR-148b levels in hepatocellular carcinoma tissues., Agonists of epoxyeicosatrienoic acids reduce infarct size and ameliorate cardiac dysfunction via activation of HO-1 and Wnt1 canonical pathway., Wnt1 promotes CD36 expression via activation of PPAR-gamma and TCF4., Data suggest that fibulin-5 functions as a metastasis suppressor in lung cancer by modulating tumor microenvironment to suppress Wnt/beta-catenin signaling., Results suggested that Wnt1-induced MAFK expression promoted cell proliferation in MG63 cells, and that the role of MAFK in osteosarcoma might be closely linked to the Wnt signaling pathway., Suggest that TGF-beta1/Smad and Wnt/CTNNB1 signaling pathways both contribute to pathological scar formation., MCF7 cells over-expressing both WNT1 and FGF3 show a 3.5-fold increase in mammosphere formation; conditioned media from these cells also promotes stem cell activity in untransfected parental MCF7 and T47D cells, as WNT1 and FGF3 are secreted factors., IWR-1 has the potential to suppress tumor metastasis by inhibiting Wnt/beta-catenin pathway as well as survivin expression, High expression of WNT1 is associated with liver cancer., Studies indicate crosstalk between Notch receptor and Wnt protein, Hedgehog protein, hypoxia and transforming growth factor beta (TGFbeta)/bone morphogenetic protein (BMP) pathways.,
OMIM_DISEASE Osteogenesis imperfecta, type XV, Osteoporosis, early-onset, susceptibility to, autosomal dominant,
SP_COMMENT function:Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters., similarity:Belongs to the Wnt family., subunit:Interacts with PORCN. Interacts with RSPO1, RSPO2 and RSPO3.,