Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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vitronectin(VTN) vitronectin(VTN) Related Genes Homo sapiens
CHROMOSOME 17,
CYTOBAND 17q11,
ENSEMBL_GENE_ID ENSG00000109072,
GENERIF_SUMMARY studies reveal that vitronectin associates with fibrin during coagulation, and may thereby modulate hemostasis and inflammation, uPA-dependent VSMC adhesion is a function of selective Vn phosphorylation by the ectoprotein kinase CK2, Mapped the fibrin binding sites in vitronectin, Plasminogen activator inhibitor type 1 promotes the self-association of vitronectin into complexes, Snake venom disintegrin, saxatilin, inhibits interaction of human umbilical vein cells to immobilized vitronectin and adhesion of smooth muscle cells to vitronectin as well as vitronectin-induced migration of the SMC cells., the rSMB domain of vitronectin is distinct from the crossed pattern present in most small disulfide bond-rich proteins, demonstrated that the avidity of heparin binding to vitronectin is governed by both the conformational state of the monomer and multimerization of the molecule, Adhesion of hairy cells to vitronectin inhibits interferon-alpha-induced apoptosis., REVIEW, strong vitronectin accumulation in extracellular matrix around some breast cancer cell clusters and in the subendothelial area of some blood vessels, importance of IGFBPs in modulating IGF-I binding to VN and that this binding has functional consequences in cells., Plasma vitronectin level potentially represents a pathogenic factor for atherogenesis and thrombus formation in patients with coronary artery disease., Results indicate that multimeric vitronectin in encapsulating peritoneal sclerosis (EPS)ascites plays a potential role in peritoneal fibrogenesis in EPS., Turnover of soluble vitronectin requires ligation of vitronectin's basic domain and that this binding event can work in trans to regulate vitronectin degradation., VN-potentiated platelet-clot interaction requires VN in the clot and multimeric VN bound to the platelet surface; self-assembly of VTN may provide a physiologically relevant contribution to platelet aggregation on a blood clot., Results describe the three-dimensional structure of an N-terminal fragment comprising the first 51 amino acids from human plasma vitronectin., Human mesenchymal stem cells cultured on purified vitronectin produce a mineralized matrix, and express osteopontin, osteocalcin, collagen I, and alkaline phosphatase., IGF-II, Structural model provides an indication of the disposition of the central domain and C-terminal heparin-binding domains of vitronectin with respect to the N-terminal somatomedin B domain., Through promoting Met-Integrin association, HGF-FN and HGF-VN complexes coordinated and enhanced endothelial cell migration through activation of the PI-3 kinase pathway involving a Ras-dependent mechanism, Vittronectin can enhance epidermal growth factor and basic fibroblast growth factor ) to enhance keratinocyte cell division., examination of the mechanism by which granzyme B cleaves vitronectin, Complexation wiwth serpin peptidase inibitor (PAI-1), with a sedimentation coefficient of 6.5 S, is the key intermediate for the assembly of higher order complexes., IGROV1 cells were shown to adhere rapidly on the HUVECs monolayer; adhesion was inhibited by anti-alphav integrin and anti-Vn blocking antibodies, but not by anti-beta1 integrin antibodies, Binding of vitronectin to outer membrane protein Haemophilus influenzae type b surface fibrils (Hsf) inhibits complement-mediated bactericidal activity and prevents complement-induced cell lysis., Osteogenesis on vitronectin correlated with enhanced focal adhesion formation, the activation of focal adhesion kinase (FAK) and paxillin, and the diminished activation of extracellular signal-regulated kinase (ERK)., PLAUR and the somatomedin B region of VTN direct the localization of UPA to focal adhesions in microvessel endothelial cells., Solution structure of recombinant somatomedin B domain from VN produced in Pichia pastoris is reported., vitronectin without the somatomedin B domain exhibits residual plasminogen activator inhibitor-1-binding activity, Vitronectin and growth factor complexes way have roles in wound healing, MMP-2 enhanced peritoneal adhesion of ovarian cancer cells through cleavage of ECM proteins fibronectin (FN) and vitronectin (Vn) into small fragments, A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor., reports the crystal structures of uPAR in complex with both urokinase (uPA) and vitronectin and reveal that uPA occupies the central cavity of the receptor, whereas vitronectin binds at the outer side of the receptor, vitronectin and integrin beta(3) contribute to the initiation of TLR2 responses, analysis of a site on PAI-1 that binds to vitronectin outside of the somatomedin B domain, ability of ovarian carcinoma cells to bind to peritoneal mesothelium in vitro and strongly suggest that vitronectin and its receptors contribute to this crucial event., pneumococci exploit the vitronectin-alphavbeta3-integrin complex as a cellular receptor for invasion and this integrin-mediated internalization requires the cooperation between the host signalling molecules ILK, PI3K and Akt., support the beneficial effect of VN on oligodendrocytic differentiation of human embryonic stem cells, These results support a model for PAI-1 binding to vitronectin in which the interaction surface extends beyond the region of PAI-1 occupied by the SMB domain., A vitronectin M381T polymorphism increases risk of hemangioblastoma in patients with VHL gene defect, Low levels of serum vitronectin is associated with febrile phase, hypotensive and oliguric phases in patients with hemorrhagic fever with renal syndrome., Vitronectin mediates a protective role at the bacterial surface by binding to nontypeable Haemophilus influenzae 3655 and reducing membrane attack complex (MAC)-induced hemolysis., Report differences in proteolytic processing of vitronectin and/or high molecular weight kininogen in women who develop preeclampsia., Data show that the expression of collagen types I, III and fibronectin was significantly higher in pancreatic cancer, and the expression of collagen type IV, laminin and vitronectin was significantly lower in pancreatic cancer., Here we show that vitronectin is the component of human serum driving stem cell differentiation through an integrin alpha V beta 3-dependent mechanism., Vitronectin may be an independent predictor of adverse cardiovascular outcomes following acute stenting in acute coronary syndromes., results suggest that in two metastatic cell lines integrin-linked N-oligosaccharides influence the VN adhesion receptor activity and function., expression of vitronectin at the periphery of mesothelial cells and within ovarian cancer cell clusters suggests a potential role for this molecule during intraperitoneal implantation of ovarian cancer cells, Data reveal that multimeric VTNC attenuate Cyr61 binding to immobilized VTNC, while monomeric VTNC was ineffective., This study directly reveals the binding mode between the N-terminal domain of UspA2 Moraxella catarrhalis and the C-terminal part of vitronectin and thus sheds light upon the mechanism of Moraxella catarrhalis-dependent serum resistance., Initial formation of IGROV1 ovarian cancer multicellular aggregates involves vitronectin., Plasminogen activator inhibitor-1 and vitronectin expression level and stoichiometry regulate vascular smooth muscle cell migration through physiological collagen matrices, Neisseria meningitidis Opc expressed in acapsulate as well as capsulate bacteria can increase human brain endothelial cell line adhesion and entry by first binding to serum vitronectin, A fragment of vitronectin containing the RGD integrin binding site showed similar binding affinity as that of full vitronectin protein to purified integrin alphavbeta3 but had diminished cell adhesion and spreading function in vivo., The results provide the first evidence for vitronectin gene expression in urothelial cells., Thrombospondin 1, fibronectin, and vitronectin are differentially dependent upon RAS, ERK1/2, and p38 for induction of vascular smooth muscle cell chemotaxis., High serum vitronectin is associated with breast cancer., PAI-2 is capable of inhibiting uPA in the presence of PAI-1, particularly on adherent cells in the presence of vitronectin, A series of truncated vitronectin molecules revealed that the C-terminal domain comprising vitronectin(353-363) harboured the major binding region for Haemophilus influenzae protein E., higgh plasms levels is associated with the risk of metabolic syndrome and type 2 diabetes mellitus, In this study, the authors demonstrate meningococcal interactions with vitronectin via a novel adhesin, Msf (meningococcal surface fibril, previously NhhA or Hsf)., There was no difference in serum vitronectin levels between Behcet's disease patients and control subjects, and there was no statistically significant difference between vitronectin levels in Behcet patients with and without ocular involvement., A strong linkage disequilibrium was found in vitronectin promoter in Chinese with vascular disease., increased expression levels of VN protein and mRNA in placental maternal-fetal interface of EOSP may be involved in adhesion and repair of placental infarct lesions., Importance of vitronectin and its interaction with the urokinase receptor in tumor growth., An isogenic nontypeable Haemophilus influenzae 3655Deltahpf mutant devoid of protein F displayed a reduced binding of vitronectin, and was consequently more sensitive to killing by human serum compared with the wild type., In conclusion, the head domains of UspA2/2H have extensive sequence polymorphism without losing vitronectin-binding capacity promoting a general evasion of the host immune system., The choline-binding protein PspC of Streptococcus pneumoniae interacts with the C-terminal heparin-binding domain of vitronectin., Interaction of vitronectin with integrin alphavbeta3 results in the continued activation of the kinase mTOR., study highlights that ascites-derived fibronectin and vitronectin exhibit different properties depending on the ascites, The presence of VN on the material surfaces enhanced cell-mediated FN reorganization and secretion., Authors demonstrate that an evolutionarily conserved rickettsial antigen, Adr1/RC1281, interacts with human vitronectin and is sufficient to mediate resistance to serum killing when expressed at the outer-membrane., Vn competes with hTSP-1 for binding to Atl repeats and vice versa. In conclusion, this study identifies the Atl repeats as bacterial adhesive structures interacting with the human glycoproteins hTSP-1 and Vn., Report role of vitronectin in the regulation of angiogenesis induced by VEGF., Gpm1 in Candida albicans attaches to human endothelial cells and to keratinocytes via the adhesive protein vitronectin, Melanoma cell adhesion to vitronectin is dependent on beta-1,6-branched N-glycans., The mean level of PAI-1 was 23.02 +/- 15 (8.2-71.19) ng/mL and vitronectin was 83.10% +/- 23.77% (12%-126%) in the tumor group., The VN level may be relevant as a clinical biomarker for adverse cardiovascular outcomes not only in patients with ischemic heart disease undergoing coronary interventions., serum levels of both fibronectin and vitronectin may be the diagnostic markers in melanoma patients, but not markers of prognosis, The interaction between uPAR and vitronectin triggers ligand-independent adhesion signalling by integrins., VTN plays a significant role in the malignant growth of tumor., Hic interacts with vitronectin and simultaneously with Factor H, and both human proteins may contribute to colonisation and invasive disease caused by serotype 3 pneumococci., A total of 17 site-specific N-glycopeptides were completely identified in all of the three N-glycosylation sites of vitronectin in human plasma, including 12 N-glycopeptides first reported., Vitronectin expression in the airways of subjects with asthma and chronic obstructive pulmonary disease, P. aeruginosa isolates obtained from CF patients significantly bound vitronectin. Porin D was defined as a novel P. aeruginosa vitronectin-receptor, Vitronectin is identified as a common constituent of amyloid deposits in 175 formalin-fixed and paraffin-embedded tissue samples from a large variety of different amyloid diseases., Lpd of P. aeruginosa is a surface exposed moonlighting protein that binds two human terminal pathway inhibitors, vitronectin and clusterin, Ail-expressing Yersinia pestis strains bind vitronectin - a host protein with functions in cell attachment, fibrinolysis and inhibition of the complement system., Bacterial protein-E and host vitronectin play a role in the attachment to bronchial epithelial cells and is also involved in the subsequent intracellular invasion of nontypeable Haemophilus influenzae., High expression of VN in tumor cells independently indicated poor clinical prognosis in patients with osteosarcoma.,
SP_COMMENT domain:The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin., function:Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity., function:Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway., PTM:It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both., PTM:N- and O-glycosylated., PTM:Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading., PTM:Sulfated on 2 tyrosine residues., similarity:Contains 1 SMB (somatomedin-B) domain., similarity:Contains 4 hemopexin-like domains., subunit:Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1 and insulin., tissue specificity:Plasma.,