Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
The Database for Annotation, Visualization and Integrated Discovery
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DAVID Functional Annotation Table
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tight junction protein 1(TJP1) tight junction protein 1(TJP1) Related Genes Homo sapiens
CHROMOSOME 15,
CYTOBAND 15q13,
ENSEMBL_GENE_ID ENSG00000104067,
GENERIF_SUMMARY Data show that connexin 43 (cx43) binds alpha-tubulin equally well as beta-tubulin, and that ZO-1 binds directly to Cx43., oxidative stress induces tyrosine phosphorylation and cellular redistribution of occludin-ZO-1 and E-cadherin-beta-catenin complexes by a tyrosine-kinase-dependent mechanism, Tyrosine phosphorylation of ZO-1 leads to down-regulation of the function of ZO-1 and dedifferentiation of the glands in colorectal cancers. These phenomena contribute to liver metastases, & redifferentiation of the glands occurs in the liver metastases., dedifferentiation and a decreased expression of E-cadherin and ZO-1 are closely related to liver metastasis, Modulatory role of VIPergic submucosal neuronal pathways on intestinal epithelial barrier permeability and ZO-1 expression., Interactions with ZO-1 and ZO-2, in particular, may mediate recruitment of armadillo repeat gene deletes in velocardiofacial syndrome protein to the plasma membrane and the nucleus, The ZO-1 present in the tight junctions in HepG2 cells cultured in the presence or absence of retinoic acid., The scaffolding protein ZO-1 co-localizes with transient receptor potential channel 4 protein TRPC4 in resting astrocytes at the cell membrane., Activation of PKC by the phorbol ester TPA induced ZO-1 and occludin transcription, whereas PKC inhibition lead to decreased expression levels, Increased ZO-1 in melanoma contributes to oncogenic behavior. Protein products of genes such as ZO-1 can function in either pro- or anti-oncogenic manner when expressed in different cellular contexts., Rsults show that ZO-1 can intervene in signaling events promoting tumor cell invasion., Structural analyses reveal that the differences between Erbin PDZ domain and the first PDZ domain of ZO-1 in specificity can be accounted for by two key differences in primary sequence., two ZO-1 complexes may coordinate two important S1P-mediated functions, i.e. migration and barrier integrity, in vascular endothelial cells, I human intestinal epithelium, ZO-1 was localized to the apical pole of cells neighboring a shedding event (shedding of epithelial cells)., Variants in TJP1 do not appear to be major determinants for albuminuria in the San Antonio Family Diabetes/Gallbladder Study., findings show that zonula occludens-1 is recruited to actin tails and pedestals; it is proposed that certain pathogenic bacteria create particular actin-rich structures that attract ZO-1 through a signal generated by WASP-related molecules, Sertoli cells associated with carcinoma in situ of the testicles show an altered distribution of ZO-1 protein and loss of blood-testis barrier function., ZO-1 accumulated at cell-to-cell junctions of the breast neoplasm cell line., Triglyceride rich lipoprotein lipolysis products regulate ZO-1 expression at endothelial cell tight junctions to alter permeability., Helicobacter pylori infected gastric epithelial cells showed altered ZO-1 distribution., the interaction between Cx43 and ZO-1 is regulated by the proteasome, It is concluded that in patients with heart failure, down-regulation of ZO-1 matches the diminished expression levels of connexin 43, suggesting that ZO-1 plays an important role in gap junction formation and gap junction plaque stability., analysis of the structure of the second of the three PDZ domains of ZO-1, which is known to promote dimerization as well as bind to C-terminal sequences on connexins, Reduced claudin-1 expression correlates with loss of differentiation in thyroid neoplasms., Findings suggest that ZO-1, by interacting with Cx43, plays a role in the down-regulation and decreased size of Cx43 gap junctions in congestive heart failure., The aims of our study were, The ZO-1 promoter region in bone marrow of myelodysplastic syndrome patients shows a hypermethylation status, which is specific for MDS., Hepatocellular carcinomas and metastases are characterized by markedly different protein expression pattern of occludin and ZO-1, which phenomenon might be attributed to the different histogenesis of these tumors., Rsults suggest that the lower epithelial alpha-catenin, E-cadherin and (or) ZO-1 expression in patients with atopic asthma contributes to a defective airway epithelial barrier and a higher influx of eosinophils in the epithelium., These data demonstrate that the tight junction undergoes constant remodeling and suggest that this dynamic behavior may contribute to tight junction assembly and regulation., JunD is a biological suppressor of ZO-1 expression in intestinal epithelial cells and plays a critical role in maintaining epithelial barrier function, domain-swapped dimerization of zonula occludens-1 PDZ2 generates a distinct interface that functions together with the well-separated canonical carboxyl tail-binding pocket in each PDZ unit in binding to connexin43 (Cx43), Targets to gap junction edges independently of several known PDZ2 domain-mediated interactions., Hepatocyte tight junctions-associated proteins occludin, claudin-1, and Zonula Occludens protein-1 (ZO-1) disappeared from the borders of adjacent cells in hepatoma cells harboring genomic hepatitis c virus replicons., tyrosine phosphorylation of Neph1 mediated by Fyn results in significantly increased Neph1 and ZO-1 binding, suggesting a critical role for Neph1 tyrosine phosphorylation in reorganizing the Neph1-ZO-1 complex., a unique motif in the occludin sequence that is involved in the regulation of ZO-1 binding by reversible phosphorylation of specific Tyr residues., Muscarinic-induced recruitment of plasma membrane Ca2+-ATPase involves PSD-95/Dlg/Zo-1-mediated interactions., ZO-1, occludin, and E-cadherin are downregulated in carcinomas arising from various compartments of the biliary tract, tick-borne encephalitis virus -NS5 has high affinity to regulating synaptic membrane exocytosis-2 (RIMS2) and Scribble, whereas DENV-NS5 binds primarily to the tight junction protein zonula occludens-1 (ZO-1), DEP-1 interacts with the tight junction proteins occludin and ZO-1 in a tyrosine phosphorylation-dependent manner., In A431 cells, ZO-1 is up-regulated by the combination of substance P and IGF-1; results thus suggest that the synergistic induction of ZO-1 expression by SP and IGF-1 may promote barrier function in skin epithelial cells, is altered in early-stage psoriasis, Study shows that ZO isoforms bind PtdInsPs and offers an alternative regulatory mechanism for the formation and stabilisation of protein complexes in the nucleus., The methylation of zo-1 may be involved in the genesis of acute leukemia., localization of cortactin in cancer cells and interaction between ZO-1 and cortactin are crucial for cancer progression., Rab13,VASP,and ZO-1 were found in apical tight junctions in normal epithelium but were dislocated to the basolateral position in patients with inactive Crohn's disease. In patients with ulcerative colitis,these tight junction proteins were not dislocated., ZO-1 gene methylation might be involved in the tumorigenesis of acute leukemia., In lower neovaginal mucosa where squamous metaplasia occurred, the expression of occludin and ZO-1 was significant;y elevated., These results suggested that although hypercholesterolemic serum could not change the expression of ZO-1, it could change the distribution and increase the permeability in endothelial cells through PI3K signaling pathway., Insights into regulated ligand binding sites from the structure of ZO-1 Src homology 3-guanylate kinase module., Demonstrate that a decrease in ZO-1 expression reduces human trophoblast cell-cell fusion and differentiation., The effects of diesel exhaust particles on endothelial vascular cell permeability and down regulation of ZO-1 are reported., Compared with healthy individuals, zo-1 gene in acute leukemia patients is hypermethylated and with different degrees in various phases of leukemia., PLEKHA7 is a cytoplasmic component of the epithelial adherens junction belt, distinct from ZO-1 and E-cadherin, the first PDZ domain of zona occludens-1 (ZO-1) and 2 (ZO-2) interacts with the carboxy-terminal PDZ binding motif of TAZ, These findings demonstrate that besides their known function in tight junction assembly and intercellular communication, zona occludens proteins and their binding partners may play a novel role in podosome formation and associated function., The zo-1 and id4 genes in multiple myeloma cell lines all were methylation positive, and the methylation positive rates were significantly higher than in normal bone marrow., ZO-1, a classical scaffold protein with accepted roles in maintaining cell-cell adhesions in stable tissues, also has an active role in cell migration during processes such as tissue development and remodelling., There was a significant difference of ZO-1 mRNA expression levels between carcinoma group and control group., Solution structure of the second PDZ domain of Zonula Occludens 1., ZO-1 regulates the rate of undocked connexon aggregation into gap junctions, enabling dynamic partitioning of Cx43 channel function between junctional and proximal nonjunctional domains of plasma membrane, ZO-1 and PLEKHA7 are paracingulin-interacting proteins that are involved in its recruitment to epithelial tight and adherens junctions, respectively, Data show that the redistribution of ZO-1 is mediated by phosphorylation of ezrin-radixin-moesin (ERM) proteins., occludin S408 dephosphorylation regulates paracellular permeability by remodeling tight junction protein dynamic behavior and intermolecular interactions between occludin, ZO-1, and select claudins, Results demonstrate a role for afadin in the regulation of vascular barrier function via coordination of adherens junction-tight junction and p120-catenin-ZO-1 interactions., 25-hydroxyvitamin D3 increases the permeability of normal bronchial airway epithelial cell monolayer in vitro, but this effect is not mediated by upregulation of ZO-1 expression., expression of ZO-1 and N-cadherin may reflect the mechanisms leading to rosette formation in neuroendocrine tumors, The significant decline in TJP1 expression in CD patients, particularly in those with coexisting T1D, was accompanied by an increase in FOXP3 expression., Data suggest that the degradation of tight junction proteins ZO-1, claudin-5 and occludin by MMP-2 and -9 secreted by leukemic cells constitutes an important mechanism in the BBB breakdown which contributes to the invasion of leukemic cells to the CNS., this study identifies a new mechanism of gap junction intercellular communication regulation in which endogenous g-protein coupled receptor agonists dynamically alter interactions between connexin43 and zonula occludens-1, ZO-1 protein is necessary for Cx50 intercellular channel formation, The structure of the PDZ3-SH3-GuK tandem of ZO-1 protein suggests a supramodular organization of the membrane-associated guanylate kinase (MAGUK) family scaffold protein core., The Src homology 3 domain is required for junctional adhesion molecule binding to the third PDZ domain of the scaffolding protein ZO-1., An implication of ZO-1 in CXCL8/IL-8 regulation. Because of the major implications of CXCL8/IL-8 in tumor invasion, such a regulation could play an important role in breast cancer progression., A crucial role is indicated crucial for Rho signaling and CREB in modulation of nuclear localization of ZO-1 and maintaining the integrity of endothelial monolayers., a 184-amino acid region (from amino acids 39 to 223) at the N-terminal region of Ubn-1 was responsible for the interaction with the PDZ2 domain of ZO-1, CPEB-mediated zonal occludens-1 mRNA localization is essential for tight-junction assembly and mammary epithelial cell polarity, tight junction protein ZO-1 (zonula occludens protein 1) has recruiting/scaffolding functions in the junctional complex of epithelial and endothelial cells, study adds new components to the multi-dentate membrane targeting mechanism and highlights the role of N- and C-terminal PDZ extensions of PSD-95/ZO-1 in the regulation of syntenin-1 plasma membrane localization, We define the interface between the ZO-1 PDZ3-SH3-U5-GuK (PSG) and occludin coiled-coil (CC) domains., The effect of myoferlin on the expression of ZO-1 in airway epithelial cells indicates its role in membrane fusion events that regulate cell detachment and apoptosis within the airway epithelium., Modeling the "airway reopening" process, examined consequent increases in pulmonary epithelial plasma membrane rupture, paracellular permeability, and disruption of the tight junction proteins zonula occludens-1 and claudin-4., PM induces marked increases in vascular permeability via ROS-mediated calcium leakage via activated TRPM2, and via ZO-1 degradation by activated calpain., findings suggest that ZO-1 and alpha-catenin are important for gap junctions containing Cx43 in the LECs, It is concluded that attenuated expression of the TJ proteins occludin and ZO-1 in human gastric epithelial cells could be involved in clopidogrel-induced gastric mucosal injury through activation of the p38 MAPK pathway, Single nucleotide polymorphisms in TJP1 is associated with response to antipsychotic agents in schizophrenia., Data suggest components of diet supplements (here, glutamine/arginine) can improve permeability and tight junction protein expression (TJP1/occludin) in enterocytes exposed to deleterious effects of antineoplastic agents (here, methotrexate)., Proteomic identification of ZO-1 binding partners and associated proteins that form tight junction complexes., The methylation positivity rates of the ID4 and ZO-1 genes in the bone marrow and paraffin-embedded lymphoma tissues of non-Hodgkin lymphoma patients were significantly higher compared to the rates in the Hodgkin lymphoma patients., ZO-1 expression is correlated with malignant phenotypes of GIST., The decreased UCP2 expression and increased ZO-1 expression suggest that the oxidative stress-induced mitochondrial dysfunction and tight junction formation may play pivotal roles in the progress of NVG., gene expression is regulated by p38MAPK, our results identify a novel regulatory pathway involving the interplay between ZO-1, alpha5-integrin and PKCepsilon in the late stages of mammalian cell division., High expression of ZO-1 is associated with good prognosis in non-small cell lung cancer., luciferase assays and chromatin immunoprecipitation assays showed that KLF4 up-regulated the promoter activities and interacted with "CACCC" DNA sequence presented in the promoters of ZO-1, occludin, and claudin-5., The presence of neural cells (PC12 cells or trigeminal neurons) markedly promoted the stratification of HCE cells as well as increased the amounts of N-cadherin mRNA and protein in these cells., Vascular endothelial tight junctions and barrier function are disrupted by 15(S)-hydroxyeicosatetraenoic acid partly via protein kinase C epsilon-mediated zona occludens-1 phosphorylation at threonine 770/772., ZO-1 showed a tendency to be detected more intensely in myocardial infarction and ischemic heart disease myocardial tissue then in asphyxiation or drowning., The LIM domain protein FHL1C interacts with tight junction protein ZO-1 contributing to the epithelial-mesenchymal transition of a breast adenocarcinoma cell line., ZO-1 gene shows a hypermethylation status in children with NHL., CFTR colocalizes with ZO-1 at the tight junctions of trachea and epididymis, and is expressed before ZO-1 in Wolffian ducts., Tjp1 expression was decreased in glomerular diseases in human and animal models, our results indicate that the suppression of Tjp1 could directly aggravate glomerular disorders, highlights Tjp1 as a potential therapeutic target., In conclusion, our present study indicated that miR-34c regulated the permeability of BTB via MAZ-mediated expression changes of ZO-1, occludin, and claudin-5., Zonula occludens-1, occludin and E-cadherin expression and organization in salivary glands, These results suggest that the localization of ZO-1 in cell-cell contacts is differently regulated by activation and inhibition of JNK and/or p38 MAPK depending on the incubation period., miR-18a and RUNX1 could reversely regulate the permeability of blood-tumor barrier as well as the expressions and distributions of ZO-1, occludin and claudin-5., ZO-1 was internalized and shown to accumulate in the cytoplasm of human podocytes in an IL-13 dose-dependent manner., ZO-1 is a central regulator of VE-cadherin-dependent endothelial junctions that orchestrates the spatial actomyosin organization., upon specific knockdown of the accessory TJP, ZO-1, undifferentiated NSCs showed decreased levels of key stem cell markers, Report TNF-alpha/Il6 mediated dysregulation of zonula occludens-1 properties in human brain microvascular endothelium., Phosphorylation state of the tyrosine of claudin-1 and claudin-2 regulates interaction with ZO1., HTT may inhibit breast tumor dissemination through maintenance of ZO1 at tight junctions., The data suggest that ZO-1, along with CD38 and Zap-70, plays a role in cell cycle regulation in chronic B cell leukemia, and may be used as a prognostic marker in the disease monitoring., These data provide the first evidence that beta-catenin and ZO-1 are direct targets of E7 of the oncogenic beta-human papillomavirus types 5 and 8.,
SP_COMMENT domain:The second PDZ domain mediates interaction with GJA12., function:The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions., PTM:Phosphorylated., similarity:Belongs to the MAGUK family., similarity:Contains 1 guanylate kinase-like domain., similarity:Contains 1 PDZ (DHR) domain., similarity:Contains 1 SH3 domain., similarity:Contains 1 ZU5 domain., similarity:Contains 3 PDZ (DHR) domains., subcellular location:Movement of ZO-1 from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact., subunit:Interacts with HSPA4 and KIRREL1 (By similarity). Homodimer, and heterodimer with TJP2/ZO-2 and TJP3/ZO-3. Interacts with occludin, claudins, CGN/cingulin, CXADR, GJA12, GJD3 and UBN1., tissue specificity:The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules.,