Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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T-cell lymphoma invasion and metastasis 1(TIAM1) T-cell lymphoma invasion and metastasis 1(TIAM1) Related Genes Homo sapiens
CHROMOSOME 21,
CYTOBAND 21q22.1, 21q22.1|21q22.11,
ENSEMBL_GENE_ID ENSG00000156299,
GENERIF_SUMMARY Tiam1 is c-Myc regulator, working in the nuclei to control c-Myc-related apoptosis, Vav2 and Tiam1 may act as downstream effectors of Src, thereby regulating Rac1-dependent pathways that participate in Src-induced cell transformation, Distinct phosphoinositides regulate different functions of Tiam1., expression level of Tiam1 in two giant-cell lung carcinoma cell strains with high or low metastasis potential, Results suggest a role for Tiam1/Rac signaling in the control of cell-cell contacts through a novel ALCAM-mediated mechanism., Rap1 promotes cell spreading by localizing a subset of Rac GEFs to sites of active lamellipodia extension, Tiam1 gene may play an important role in invasion and metastasis of colorectal carcinoma and is a metastasis-related gene., Tiam1 activates Rac and contributes to Rac signaling specificity through binding to IRSp53., S1P-induced recruitment of S1P1 to CEM fractions promotes PI3 kinase-mediated Tiam1/Rac1 activation required for alpha-actinin-1/4-regulated cortical actin rearrangement and EC barrier enhancement, Overexpression of the Tiam1 gene correlates with invasion and metastasis of nasopharyngeal carcinoma., Data suggest that strong Tiam1 overexpression relative to the corresponding benign epithelial cells is a new and independent predictor of decreased disease-free survival for patients with prostate cancer., Tiam1 is overexpressed in a subset of human colorectal tumors. It affects multiple properties associated with acquisition of the metastatic phenotype & may represent a marker of colon tumor progression & metastasis in a subset of tumors., Tiam1 plays a causal role in the metastasis of colorectal cancer, Tiam1 and betaPIX mediate OxPAPC-induced Rac activation, cytoskeletal remodeling, and barrier protective response in pulmonary endothelium, Tiam1 transfection in colorectal cancer cells could upregulate the expression of Fascin-1, heat shock protein 27 (HSP27), high-mobility group box 1 (HMGB1), glutathione S-transferase omega 1 (GSTO1) and downregulate the expression of annexin IV., Data show that Tiam-1 gene may play an important role in invasion and metastasis of colorectal cancer., CD44 is an important regulator of HGF/c-Met-mediated in vitro and in vivo barrier enhancement, a process with essential involvement of Tiam1, Rac1, dynamin 2, and cortactin., Tiam1 gene plays an important role in the proliferation, invasion and metastasis of colorectal cancer., 16k PRL inhibits cell migration by blocking the Ras-Tiam1-Rac1-Pak1 signaling pathway in endothelial cells, Results identify three genes, high-mobility group box1, annexin IV and phosphoglycerate mutase 1 that were associated with Tiam1 and may be involved in colorectal cancer metastasis., Tiam1, a Rac1-specific guanine nucleotide exchange factor, was expressed mainly in the cytosol of AT2 cells exposed to mechanical strain compared with membrane localization in static cells., results suggest that Rac1 and the Rac1-specific activator Tiam1 are components of transcriptionally active beta-catenin/TCF complexes at Wnt-responsive promoters, and Rac1 and Tiam1 within these complexes serves to enhance target gene transcription, Tiam1 expression may be a novel and independent predictor for the prognosis of hepatocellular carcinoma, Tiam1 counteracts the progression of breast carcinomas and is suitable as a novel breast tumor marker., PAF-induced IEJ disruption and increased endothelial permeability requires the activation of a Tiam1-Rac1 signaling module, suggesting a novel therapeutic target against increased vascular permeability associated with inflammatory diseases., Tiam-1 expression is closely associated with the invasiveness and metastasis of nasopharyngeal carcinoma., Tiam1 is related to the metastasis of colorectal carcinoma, and may induce epithelial-mesenchymal transition to promote metastasis., Overexpression of Tiam1 is associated with lymphangiogenesis in colorectal carcinoma., SRC-induced disassembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiam1., Upregulation of Tiam1 and Rac1 proteins may play a critical role in tumor progression of nasopharyngeal carcinoma, Tiam1 expression correlates with the invasion and metastasis of nasopharyngeal carcinoma cells., The expression of Tiam1 was significantly higher in breast carcinomas than in normal breast tissue, and was correlated to node metastasis and clinical stage., Expression of constitutively active PI3K stimulated translocation of Tiam1 to the membrane, increased Rac1 activity, and increased wound healing of airway epithelial cells., results indicate that Tiam1 integrates signals from CADM1 to regulate the actin cytoskeleton through Rac activation, which may lead to tissue infiltration of leukemic cells in ATL patients, IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1, Cell biological analysis established that Syndecan1 is a physiological binding partner of Tiam1 and that the PDZ domain has a function in cell-matrix adhesion and cell migration., Mechanism for the regulation of Tiam1-mediated Rac protein activation in breast cancer., regulates EphA8-ephrinA5 signaling and clathrin-mediated endocytosis, Increased TIAM1 is associated with vascular invasion and intrahepatic metastasis hepatocellular carcinoma., Stromal Tiam1 has a role in modulating the effects of the tumor microenvironment on malignant cell invasion and metastasis., Tiam1 expression correlates with cell motility in breast cancer cells and is required to support the motile phenotype; localization of endogenous Tiam1 to the Golgi, and its role in Golgi reorientation, suggest it may support motility through a mechanism discrete from its known function in leading edge dynamics, Data show that TIAM1, a guanidine exchange factor of the Rac GTPase, is a direct target of both miR-21 and miR-31., Tiam1 may be used as molecular marker for predicting the prognosis of patients with esophageal squamous cell carcinoma., promotor hypomethylation of T-lymphoma invasion and metastasis 1 may play a role in the progression and metastasis of colorectal cancer, These findings suggest a previously unrecognized mechanism of integrin-induced Rac1 activation in which 14-3-3 dimers localize Tiam1 to integrin complexes, where it mediates integrin-dependent Rac1 activation, thus initiating motility-inducing pathways., Tiam1 and Rac1 expressions may be independent predictors for the poor prognosis in patients with primary gallbladder carcinoma, Activation through the T cell receptor results in phosphorylation of LFA-1 that leads to engagement of Tiam1 and Rac1, Tiam1 is an invasion and metastasis inducing factor of lung carcinoma. The overexpression of Tiam1 is closely associated with lymph node metastases, TNM stage and histological types of lung carcinoma., Tiam1 may be involved in the aggressive behavior of ovarian cancer, and differential expression of microRNA may contribute to the dysregulation of Tiam1, which contributes to the invasive, migratory and viability properties of ovarian cancer cells, High Tiam1 protein expression is associated with lung cancer development and metastasis., Results indicate that Tiam1, as a metastasis-related gene, may contribute to HCC invasion and metastasis., Tiam1, with the PAR complex, binds to integrins through talin and, together with the PAR complex, thereby regulates Rac1 activity and adhesion turnover for polarized migration., The miR-29c/TIAM1 pathway further elucidates the molecular mechanisms regulating invasion and metastasis in nasopharyngeal carcinoma., Tiam1 is closely related with invasion and metastasis of breast carcinoma., PGD(2)-DP signaling reduces vascular permeability via endothelial cAMP/PKA/Tiam1/Rac1 pathway., these results suggest that the progression of pancreatic tumors is partially controlled by the balance between Tiam1-rac1 and RhoA., In gastric cancer cells, Tiam1 affects multiple properties associated with acquisition of the metastatic phenotype, and may be a marker of gastric cancer progression and metastasis in a subset of cancer., MiR-22 expression inhibited TIAM1 mRNA and protein expression., Over-expression of Tiam-1 contributes to the invasive phenotype of gastric cancer cells., Downregulation of Tcell lymphoma invasion and metastasisinducing factor 1 induces cytoskeletal rearrangement and inhibits the invasive capacity of gastric cancer cells., Due to their specificity over related GEF proteins they may represent promising tools for further elucidation of the biological functions of Tiam1., Data show that T lymphoma invasion and metastasis protein (Tiam1) modulates the cell invasion, mediated by actin cytoskeleton remodeling in retinoblastoma (RB)., nitric oxide is a key molecule promoting endothelial cell permeability, linking the cytoskeleton to VE-cadherin phosphorylation through regulation of the endothelial-junction-associated Rac guanine-nucleotide-exchange factor (GEF) TIAM1., Tiam1 associates with EphA2 receptors in early endosomes and is required for endocytic trafficking of EphA2 receptors., Data show that T-lymphoma invasion and metastasis inducing factor 1 (Tiam1) may contribute to squamous-cell carcinoma of the head and neck (SCCH) progression, and represent as a prognostic indicator as well as a potential therapeutic target for SCCHN., The 5-LOX/LTC4 /CysLT1 signaling pathway regulates EGF-induced cell migration by increasing Tiam1 expression., Authors propose a model for Rac1 activation where SIRT1/2 positively modulates the DVL/TIAM1/Rac1 axis and promotes sustained pathway activation., The rs13048019 in the TIMA1 gene are unlikely to be common cause of SALS in Chinese population, Tiam1 contribute to chronic lymphocytic leukemia cells proliferation and chemoresistance., miR-141 functions as a tumor suppressor and inhibits the migration and invasion of hepatocellular carcinoma cells by targeting Tiam1., TIAM1-RAC1-NOX2 signalling axis is activated in the initial stages of diabetes to increase intracellular ROS leading to mitochondrial damage and accelerated capillary cell apoptosis, Tiam1 expression may be beneficial in predicting lymph node metastasis and survival of patients with lung adenocarcinoma, Our results uncover that inhibition of proteasome-mediated Tiam1 degradation is an upstream event leading to Rac1/JNK activation and cell apoptosis in response to DNA-damaging drug treatment., TIAM1 is activated by phosphatidylinositol 5-phosphate which activates RAC1, regulating actin dynamics and cell invasion., Data support the notion that Tiam1 plays an important role in the progression of nasopharyngeal carcinoma (NPC), and its overexpression is associated with malignant phenotypes of NPC., MiR-29b suppresses tumor growth and metastasis in colorectal cancer via downregulating Tiam1 expression., These data demonstrate, that in addition to microtubule-independent Tiam1 activation, HGF engages additional microtubule- and APC-dependent pathway of Asef activation., Degradation of Tiam1 by casein kinase 1 and the SCFbetaTrCP ubiquitin ligase controls the duration of mTOR-S6K signaling., we show that HUWE1 stimulates human lung cancer cell invasion through regulating TIAM1 stability. Finally, we demonstrate that HUWE1 and TIAM1 protein levels are inversely correlated in human lung carcinomas, We identified T lymphoma invasion and metastasis 1 (TIAM1) gene as potential target of miR-329 in gastric cancer, These results suggested that Tiam1 overexpression in LSCC is possibly involved in the promotion of migration and invasion, and is a promising therapeutic target in the prevention of the progression of LSCC., Heterodimeric CUL3 proteinubiquitylates TIAM1.CUL3 regulates TIAM1 abundance and subsequent RAC1 signaling., Study identifies a bidirectional (phosphorylation and dephosphorylation) regulatory mechanism controlling Tiam1 stability and provides new insights on how EGFR signaling triggers Rac1 activation and cancer development., The downregulation of MiR-182 is associated with the growth and invasion of osteosarcoma cells through the regulation of TIAM1 expression., The polymorphisms rs2833188 and rs2833195 in TIAM1 gene may be associated with some clinical characteristics in children with Kawasaki disease., fibroblast expression patterns of Tiam1 and osteopontin in human breast cancers show converse changes correlating with invasion, supporting the hypothesis that this pathway in tumor-associated fibroblasts regulates breast cancer invasiveness,
SP_COMMENT function:Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA., similarity:Belongs to the TIAM family., similarity:Contains 1 DH (DBL-homology) domain., similarity:Contains 1 PDZ (DHR) domain., similarity:Contains 1 PH domain., similarity:Contains 1 RBD (Ras-binding) domain., similarity:Contains 2 PH domains., subunit:Interacts with BAIAP2., tissue specificity:Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.,