Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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SRC proto-oncogene, non-receptor tyrosine kinase(SRC) SRC proto-oncogene, non-receptor tyrosine kinase(SRC) Related Genes Homo sapiens
CYTOBAND 20q12-q13,
GENERIF_SUMMARY Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton., v-Src's hold over actin and cell adhesions., PLD1 is threonine-phosphorylated in human-airway epithelial cells by a PKCdelta and src dependent mechanism, The Src-cortactin pathway is required for clustering of E-selectin and ICAM-1 in endothelial cells, Activation of a Src-dependent Raf-MEK1/2-ERK signaling pathway is required for IL-1alpha-induced upregulation of beta-defensin 2 in human middle ear epithelial cells., REVIEW, Functional involvement of src and focal adhesion kinase in a CD99 splice variant-induced motility of human breast cancer cells, The p85 subunit of PI 3-kinase activates Src independently of the enzymatic activity of PI 3- kinase. Ligand binding of GPIb, without receptor clustering, is sufficient to activate Src., pp60c-src may be involved in stabilization of dynamic HT-29 cell adhesion to ECM components, and this kinase appears to be part of a mechanosensory protein complex during integrin-mediated cell adhesion, Src activation may contribute to colon tumor progression and metastasis in part by activating Akt-mediated survival pathways that decrease sensitivity of detached cells to anoikis., mediation of synergism with epidermal growth factor receptor by STAT5b, Data report a novel positioning of Src, mediating signals from insulin to phosphatidylinositol 3-kinase and to beta(2)-adrenergic receptor trafficking., Mutual interaction of c-Src with EGFR is required for many EGFR-mediated cellular functions including proliferation, migration, survival and EGFR endocytosis, as discussed in this review., c-Src activation is associated with early stages of breast carcinomas with low aggressiveness., src has a role in promoting destruction of c-Cbl and enabling EGFR to evade desensitization as part of an oncogenesis pathway, c-Src, lacking cysteine at position 520, is resistant to 1 microM N-(9-acridinyl) maleimide (NAM) but sensitive to 5 microM. Changing Phe520 to cysteine made it sensitive to 1 microM. Double mutation in clustered cysteines restored resistance to 5 microM., Results demonstrate that c-Src and TRAF6 are key mediators of interleukin-1-induced AP-1 activation and provide evidence of cross talk between c-Src and TRAF6 molecules through PI3 kinase-Akt-JNK pathways., c-Src regulates NAD(P)H oxidase-derived *O2- generation acutely by stimulating p47phox phosphorylation and translocation and chronically by increasing protein content of gp91phox, p22phox, and p47phox in Ang II-stimulated cells., stimulated by HBX protein acting on the mitochondrial transition pore and effecting hepatitis B virus replication., involvement of G(i), Src tyrosine kinase and PI3 Kinase, respectively, in TNFalpha production, v-SRC regulates the nucleo-cytoplasmic delocalization of the major isoform of TEL-ETV6, role of c-Src on PRL-stimulated proliferation of T47D and MCF7 breast cancer cells, a triple complex between AR, p85alpha, and Src is required for androgen-stimulated PI3K/Akt activation, FAK and Src are both important survival factors, playing a role in protecting colon cancer cell lines from Adenovirus-containing FAK-CD (Ad-FAK-CD)-induced apoptosis, Inhibition of Src signaling results in a marked reduction of pancreatic cancer cellular invasiveness. Src may represent a novel therapeutic target for this deadly cancer., Src has an appreciable role in the organization of the Golgi apparatus, which may be linked to its involvement in protein transport from the Golgi apparatus to the endoplasmic reticulum, SRC tyrosine kinases are activated and have a role in tyrosine phosphorylation of ezrin and activation of p38, c-src activation of PLCgamma is mediated by GIT1, The data indicate an increase in the expression and total activity of endogenous p60(c-Src) in several GM-CSF-independent 1 cultured leukemia cell mutants., focal adhesion kinase and src are stimulated by G alpha q and platelet activating factor receptor in vascular endothelium, role of IGF-1R and c-Src in human pancreatic carcinogenesis. Coexpression of both these molecules may play important role in transformation of pancreatic ductal cells., data suggest that agonist-induced binding of Src kinase to the Src homology 3 binding sites in the P2Y(2) purinergic receptor facilitates Src activation and allows Src to efficiently phosphorylate the epidermal growth factor receptor, A novel regulatory network RAFTK/Pyk2, Src and p38 appears to be critical for VEGF-induced endothelial cell migration., v-Src and receptor tyrosine kinase ErbB2 activate beta-catenin-TCF-mediated transcription., Ret tyrosine 981 constitutes the major binding site of the Src homology 2 domain of Src and therefore the primary residue responsible for Src activation upon Ret engagement, EGFR and c-Src-mediated Stat-3 activation is facilitated by Pyk2, src and protein kinase C have roles in inducing phosphorylation of p38 mitogen-activated protein kinase in epithelial cells after mechanical pressure, mechanisms of c-Src activation in human cancer (review), both the androgen receptor interacting domains of the coactivator SRC1 and of the corepressor SMRT compete for interaction with the androgen receptor N-terminus, SH2 and SH3 domains of Src mediate peripheral accumulation of phospho-myosin, leading to integrin adhesion complex assembly, whereas loss of SH2 or SH3 function restores normal regulation of E-cadherin and inhibits vimentin expression, hTAF(II)68-mediated transactivation is linked to the cytoplasmic Src signal transduction pathway. The hTAF(II)68 protein can associate with the SH3 domains of several cell signaling proteins, including v-Src., data suggest that colony-stimulating factor receptor-1R (CSF-1R) disrupts cell adhesion by uncoupling adherens junction complexes from the cytoskeleton and promoting cadherin internalization through a Src-dependent mechanism, Src kinase activity is suppressed by RAC1, which regulates G1/S progression, Src plays an obligatory role in the mechanism for receptor and diacylglycerol activation of TRPC3, Results provide important insight to the mechanism of SRC transcriptional activation in liver cancer cells., A prolactin signalling cascade in W53 cells involves Src kinases that mediate stimulation of c-Myc expression., colony stimulating factor 1 receptor phosphorylation was not markedly affected by Src-family kinases (SFK) inhibition, indicating that lack of SFK binding is not responsible for diminished Y559F phosphorylation., Src inhibitors inhibited COX-2 induction in Helicobacter pylori infected gastric mucosa cells., Fibronectin and type IV collagen activate ERalpha AF-1 by the c-Src pathway in breast cancer, G16-mediated activation of nuclear factor kappaB by the adenosine A1 receptor requires c-Src, protein kinase C, and ERK signaling, c-Src participates in regulating the endocytosis of PDGFbeta receptor-GPCR complexes in response to PDGF., c-Src has a role in regulating the dissociation of AP-2 from agonist-occupied AT1R and beta-arrestin during the clathrin-mediated internalization of receptors, Data demonstrate that type I collagen synergistically enhances platelet-derived growth factor (PDGF)-induced smooth muscle cell proliferation through Src-dependent crosstalk between the alpha2beta1 integrin and the PDGF receptor beta., src kinase potentiates tamoxifen agonist action through serine 167-dependent stabilization of estrogen receptor promoter interaction and through elevation of SRC-1 and cAMP response element binding protein-binding protein coactivation of ER, ERK activation mediated pure pressure-induced proliferative response of aortic smooth muscle cells. This activation was partly mediated by c-Src., FRS2-dependent SRC activation is required for FGFR-induced phosphorylation of Sprouty and suppression of ERK activity, there is a complex interplay between PKCalpha, Syk, and Src involving physical interaction, phosphorylation, translocation within the cell, and functional activity regulation, PMA transactivates the EGFR and increases cell proliferation by activating the PKCdelta/c-Src pathway in glioblastoma cells, Csk achieves a low K(m) for the substrate Src, not by stabilizing protein-protein interactions but rather by facilitating a fast phosphoryl transfer step, Src phosphorylates ezrin at tyrosine 477, Involvement of c-Src and protein kinase C delta in the inhibition of Cl(-)/OH- exchange activity in Caco-2 cells by serotonin., Src-dependent ezrin phosphorylation has a role in adhesion-mediated events in epithelial cells, SRC-1 is a novel Smad3/4 transcriptional partner, facilitating the functional link between Smad3 and p300/CBP., Data show that ionizing radiation causes stress-induced activation of insulin-like growth factor-1 receptor-Src-Mek-Erk-Egr-1 signaling that regulates the clusterin pro-survival cascade., HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE regulate Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas, data demonstrate that Src tyrosine kinase modulates human airway smooth muscle (ASM) cell proliferation and migration, results indicated that Src kinase-dependent tyrosine phosphorylation of p47(phox) regulates hyperoxia-induced NADPH oxidase activation and reactive oxygen species production in human pulmonary artery endothelial cells, a specific cross-talk between TGF-beta1 and fibronectin-binding integrin signal pathways leads to the activation of c-Src/Rac1/actin-organization, leading to changes in cell cycle regulator levels in hepatoma cells, c-src codon 531 mutation in colorectal cancer is not the cause of c-src activation., This review summarizes some of the latest evidence for the role of c-Src in tumorigenesis and particularly in human tumor progression., calcium activates PLC-gamma1 via increased PIP3 formation mediated by c-src- and fyn-activated PI3K, dynamin, Cbl, and Src coordinately participate in signaling complexes that are important in the assembly and remodeling of the actin cytoskeleton, leading to changes in osteoclast adhesion, migration, and resorption, c-Src tyrosine kinase was identified as a binding partner of the BMPR-II C-terminus., Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway, MUC1 is delivered to mitochondria by a mechanism involving activation of the ErbB receptor-->c-Src pathway and transport by the molecular chaperone HSP70/HSP90 complex, The Src, a proto-oncogene, has been strongly implicated in the growth, progression and metastasis of a number of human cancers., Src activity contributes to constitutive and EGF-induced VEGF expression and angiogenic potential in pancreatic cancer cells, Data report three crystal structures of a dimeric active c-Src kinase domain, in an apo and two ligand complexed forms, with resolutions ranging from 2.9A to 1.95A., FAK regulates integrin-dependent MMP-2 and MMP-9 expression and release by T lymphoid cells through src kinase, rhMIF induced VCAM-1 and ICAM-1 up-regulation in 12 hours via Src, PI3K, and NFkappaB, LPC-induced Flk-1/KDR transactivation via c-Src may have important implications for the progression of atherosclerosis, Data suggest a model in which netrin stimulates UNC5 tyrosine phosphorylation and signaling in a manner dependent on the co-receptor DCC, through the recruitment of Src and FAK kinases., Stat3 downregulation in vSrc transformed NIH3T3 cells or in breast cancer lines with activated Src induces apoptosis, but in normal cells Stat3 inhibition at post-confluence causes apoptosis while in sparsely growing cells it induces growth retardation, Cells with single Src family kinase knockdown show that Src, Fyn and Yes kinases are all required for vascular endothelial growth factor (VEGF) mitogenic signaling., Epidermal growth factor receptor exposed to oxidative stress undergoes Src- and caveolin-1-dependent perinuclear trafficking, These studies also raise the possibility that fully active forms of c-Src and Fak in breast tumors., IR-induced ERK1/2 activation involves EGFR through a Src-dependent pathway that is distinct from EGFR ligand activation, The results demonstrate that collagen-evoked ectodomain cleavage of DDR1 is mediated in part by Src-dependent activation, Data show that the interaction between Src and major vault protein (MVP) is critically dependent on Src activity and protein (MVP) tyrosyl phosphorylation, which are induced by epidermal growth factor stimulation., Results suggest that c-Src may be involved in the formation of giant cells in cherubism, central giant cell granuloma and giant cell tumors., arginine dimethylation of heterogeneous nuclear ribonucleoprotein K by protein-arginine methyltransferase 1 inhibits its interaction with c-Src, These data suggest that FAK might differently regulate apoptosis and focal adhesion formation through site-specific, Src-dependent tyrosine phosphorylation in senescent cells., nephrin phosphorylation results in Src kinase activation, recruitment of Nck, and assembly of actin filaments in an Nck-dependent fashion, Although a key factor in TRAF6-dependent activation of PI 3-kinase, ectopic expression of Src was insufficient for NF-kappaB activation and, in contrast to NF-kappaB, was not inhibited by IRAK2., Src activation triggers Caspase-8 phosphorylation on Tyr380 and impairs Fas-induced apoptosis., Study shows EGF-stimulation-induced Csk-binding protein (Cbp) tyrosine phosphorylation followed by Cbp-Csk association, in a SFK-dependent manner., nNOS is a new p60(src) kinase substrate essential for SST5-mediated anti-proliferative action, the Src/Fak complex has a role in breast cancer tumorigenesis, Upon IGF-I stimulation, a complex assembles on SHPS-1 that contains SHP-2, c-Src, and Shc wherein Src phosphorylates Shc, a signaling step that is necessary for an optimal mitogenic response, v-Src-dependent down-regulation of the Ste20-like kinase SLK through casein kinase II., Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent p85 PI3K and Akt and Erk activation, Nicotine induces cell proliferation by beta-arrestin-mediated activation of the Src and Rb-Raf-1 pathways om ;img camcer., extracellular matrix fragments produced by apoptotic EC initiate a state of resistance to apoptosis in fibroblasts via an alpha2beta1 integrin/SFK (Src and Fyn)/phosphatidylinositol 3-kinase (PI3K)-dependent pathway, A key coactivator for the proper function of HNF4 alpha in human liver and for an integrative control of multiple hepatic genes involved in metabolism and homeostasis., Genetic alterations of SRC1 are rare in prostate cancer. The nuclear protein accumulation of SRC1 seems to be mildly increased in androgen ablation resistant prostate cancers. ., inhibition may be an attractive therapeutic approach for patients with ovarian carcinoma, Curcumin treatment inhibited v-src gene expression in K562 chronic leukaemia cells., steps involving Src association, phosphorylation, and product release are fast, and a structural change in Csk participates in limiting the catalytic cycle, HSP90 binding to ErbB2 participates in regulation of src kinase activity as well as kinase stability, data delineate multiple PTH1R structural determinants for ERK1/2 activation and identify mechanism involving proline-rich motifs in receptor C terminus for reciprocal scaffolding of c-Src and beta-arrestin2 with a class II G-protein-coupled receptor, SHP1 activation, association with Src and dephosphorylation of specific proteins were dependent on extracellular calcium and maintenance of a higher cytosolic calcium plateau., These results suggest that dimerization of Src plays an important role in the regulation of Src tyrosine kinase activity., Serum-independent growth of 5637 cells involves the transmembrane signaling cascade via EGFR ligand(s) (but not HGF), EGFR, Src and p145(met), Src and Rac1 have roles in focal adhesion kinase and ERK mitogenic signaling in epithelial cells, Stimulation of collagen type I secretion by TGF-beta requires a PKCdelta-Src-ERK1/2 signaling motif., Src and focal adhesion kinase mediate cyclic mechanical strain-induced extracellular regulated kinase phosphorylation and proliferation of pulmonary epithelial cells., P60-c-src suppresses apoptosis through inhibition of caspase 8 activation in hepatoma cells., These lines of evidence suggested that a Gq-coupled receptor activates specifically p38 MAPK through lipid rafts and Src kinase activation, in which flotillins positively modulate the Gq signaling., results delineate a novel force-activated inside-out Src/PI3K/FAK/Akt pathway by which cancer cells regulate their own adhesion., study elucidated a nongenomic extranuclear signal mediated by the RAR-SRC interaction that is negatively regulated by CSK and is required for RA-induced neuronal differentiation, Src plays a crucial role in CUTL1-induced tumor cell migration, Fak/Src signaling to the PI3-K/Akt-1 and MEK/Erk pathways undergoes a differentiation state-specific uncoupling in enterocytes., CD99 isoforms dictate opposite functions in tumour malignancy and metastases by activating or repressing c-Src kinase activity., These data suggest that Src-induced u-PAR gene expression and invasion/intravasation in vivo is also mediated via AP-1 region -190/-171, especially bound with c-Jun phosphorylated at Ser(73/63)., The interplay between palladin, SPIN90 and Src and characterized the role of palladin and SPIN90 in platelet derived growth factor and Src-induced cytoskeletal remodeling, was analyzed., These results suggest that palmitoylation of Src-family kinases (SFKs) is critical for SFK localization and trafficking and implicate that two distinct trafficking pathways for SFKs may be involved in SFKs' specific functions., E-cadherin signaling is an important activator of c-Src at cell-cell contacts, providing a key input into a signaling pathway where quantitative changes in signal strength may result in qualitative differences in functional outcome., These findings support a novel role for RACK1 as a key regulator of cell migration and adhesion dynamics through the regulation of Src activity, and the modulation of paxillin phosphorylation at early adhesions., Indirect evidence for an impaired src kinase regulation of I (Ca,L) together with an increased phosphatase activity suggests that a complex alteration in the kinase/phosphatase balance leads to I (Ca,L) dysregulation in chronic AF., Activated c-Src may play a role in survival, metastasis, and invasion of malignant pleural mesothelioma, c-Src controls functional association between integrin alphav-beta3 and VEGFR-2 via integrin beta3 phosphorylation., These results demonstrate that the chimeric strategy is useful for detailed dissection of the mechanistic basis of substrate specificity and regulation of protein tyrosine kinases., norepinephrine stimulation activates Src tyrosine kinase and this activation is required for increased IL-6 expression, Endothelial Src activity is required for ICAM-mediated tyrosine phosphorylation of vascular endothelial cadherin and for efficient neutrophil migration during passage of leukocytes across the vascular endothelial monolayer., Src was identified as Death-associated protein kinase (DAPK) regulator through their reciprocal modification of DAPK Y491/492 residues and establishes a functional link of this DAPK-regulatory circuit to tumor progression., Colorectal cancer cells may develop acquired resistance to cetuximab via altering EGFR levels through ubiquitination and degradation and using Src kinase-mediated cell signaling for cell growth and survival., TAE226-induced apoptosis in breast cancer cells with overexpressed SRC., analysis of Src and C-terminal Src kinase interactions in integrin alphaIIbbeta3-mediated signaling to the cytoskeleton, These observations suggest that within in vivo-like conditions Src may have a leading role in the induction of sustained ERK1/2 activation through the Src/Ras/Raf pathway., These results reveal a potentially important role for CHK in Src activation and tumorigenicity in colon cancer cells., human breast cells are a uniquely permissive environment for HGF transactivation by Src/Stat3 which may allow for the inappropriate activation of HGF transcription during the early stages of breast transformation, This study suggests that (a) PTP1B can act as an important activator of Src in colon cancer cells via dephosphorylation at Y530 of Src and (b) elevated levels of PTP1B can increase tumorigenicity of colon cancer cells by activating Src., Brk-mediated STAT5b phosphorylation leads to STAT5b transcriptional activity, and this activity is further increased by kinase active c-Src., These data suggest that phosphorylation of PDK1 on Tyr(9), distinct from Tyr(373/376), is important for PDK1/Src complex formation, leading to PDK1 activation., Silencing Cdc42 blocks activation of EGFR and Src induced by Ca2+ depletion, resulting in a reduction in E-cadherin degradation, Col-IV regulates the secretion of MMP-9 via a Src and FAK dependent pathway in MCF-7 cells, The SRC-STAT5 pathway is essential for decidualization of estrogen-primed human endometrial stromal cells., novel mechanism of c-SRC regulation whereby in response to stress c-SRC activity is regulated, at least in part, through loss of the interaction with its inhibitor, PR55gamma, there is functional conservation between Qr domains of yeast Gal11p and mammalian SRC proteins as direct targets of activator proteins in yeast., TNF activated ERK in an EGFR and Src dependent and an EGFR and Src independent modes, attenuation of the Erk1/2 signaling pathway is essential for andrographolide-mediated inhibition of v-Src transformation, Association of caspase-8 and Src may help reconcile why a potential tumor suppressor such as caspase-8 is rarely absent in cancers., c-Src is a mediator of substance P-stimulated ERK1/2 phosphorylation in human U373 MG glioblastoma cells., Src-dependent phosphorylation at Tyr-529 facilitates inactive ERK binding to RSK2, which might be a general requirement for RSK2 activation by EGF through the MEK/ERK pathway., VE-cadherin has a role in modulating c-Src activation in VEGF signaling, This study analysed whether the serotonin transport mediated by the plasma-membrane transporter SERT is regulated by its Tyr-phosphorylation., CD63 plays a role in the regulation of ROMK channels through its association with RPTPalpha, which in turn interacts with and activates Src family PTK, thus reducing ROMK activity., Src, a nonreceptor tyrosine kinase, is overexpressed in androgen-independent prostate carcinoma, These data provide direct evidence for increased activation of Src-family tyrosine kinases in the pathogenesis of hyperproliferative epidermal disorders., a new signaling connection from ILK to cofilin for dynamic actin polymerization during cell adhesion, depending on the activity of ILK-associated c-Src., Anoikis causes a down-activation of Fak, Src, Akt-1 and Erk1/2, a loss of Fak-Src association, and a sustained/enhanced activation of p38b, which is required as apoptosis/anoikis driver, results indicate that Src and E-cadherin may play an important role in epithelial-mesenchymal transformations, invasion, and aggressive clinicopathologic features of head and neck squamous carcinoma, results demonstrate that TGFbeta1 induces alphavbeta3 integrin expression via a beta3 integrin-, c-Src-, and p38 MAPK-dependent pathway, Role of Src kinase in the early action of TCDD through a nongenomic pathway in MCF10A cells is reported., Rac1-dependent NADPH oxidases play a critical role in activating c-Src following hypoxia/reoxygenation injury, These findings suggest a novel MUC1-Src-CrkL-Rac1/Cdc42 signaling cascade following ICAM-1 ligation, through which MUC1 regulates cytoskeletal reorganization and directed cell motility during cell migration., Within the endothelial cell, p11 is required for Src kinase-mediated tyrosine phosphorylation of A2, which signals translocation of both proteins to the cell surface., hnRNP K binds to the 3'-untranslated region of the c-Src mRNA and inhibits its translation by blocking 80 S ribosome formation, Csk serves to maintain the constancy of baseline excitatory synaptic transmission by inhibiting Src kinase-dependent synaptic plasticity in the hippocampus, A Met/c-Src-mediated signaling pathway is a mediator of EGFR tyrosine phosphorylation and cell growth in the presence of EGFR tyrosine kinase inhibitors., These results suggest that Src-family tyrosine kinases, including c-Src and Lyn, are involved in formation of the cortical actin cap, which may serve as a platform of tyrosine phosphorylation signaling., c-Src is an important regulator of Nox1 activity, tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases are regulated by phosphorylation, Src phosphorylation of Bif-1 suppresses the interaction between Bif-1 and Bax, resulting in the inhibition of Bax activation during anoikis., Src kinase, in conjunction with antihormone therapies, effectively prevents antihormone resistance in breast cancer cells in vitro, a critical role for a EGF-R-connected p60c-src-kinase-mediated pathway involving STAT3 and contributing to cell survival and proliferation within colorectal carcinomatumours., The effect of OGP(10-14) on differentiation of a cancer megakaryoblast cell line and its involvement on RhoA and Src family kinases signaling pathway, was evaluated., pp60c-Src TK-activity was selectively induced by VEGF in MM tumor and ECs, These studies demonstrate positive cross talk between ER, c-Src, EGFR, and STAT5b in ER+ breast cancer cells., the Src-specific sites are all required for overexpressed Focal adhesion kinase to inhibit invadopodia formation., This study reveals for the first time that alpha-catenin is a key regulator of beta-catenin transcriptional activity and that the status of alpha-catenin expression in tumor tissues might have prognostic value for Src targeted therapy, expression and activation of c-Src as well as EGF receptor promotes head and neck squamous cell carcinoma progression, PLCgamma-1 and c-Src activation contribute to HNSCC invasion downstream of EGF receptor, study shows that TNFR1 associates with Jak2, c-Src, and PI3K in various cell types to engage signaling pathways, activate transcription factors, and modulate gene expression, Regulation of hERG channels by protein tyrosine kinases modifies the channel activity and thus likely alters electrophysiological properties including action potential duration and cell excitability in human heart and neurons., analysis of PAFR activation and pleiotropic effects on tyrosine phospho-EGFR/Src/FAK/paxillin in ovarian cancer, This study demonstrates an important role of the dynamic raft reorganization induced by CD44 clustering in eliciting the matrix-derived survival signal through the CD44-SRC-integrin beta1 axis ., PI3K and Src-ELMO-Dock2 pathways work in parallel to activate Rac2 and modulate chemotaxis in response to a CXCL8 gradient in neutrophils., In vascular smooth muscle cells shedding of membrane-bound epidermal growth factor (EGF) receptor ligands and activation of the nonreceptor tyrosine kinases Pyk2 and Src contributed to the thrombin-induced ERK1/2 phosphorylation., The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing., c-Src is involved in lipoteichoic acid-induced heme oxygenase-1 expression in human cultured tracheal smooth muscle cells., data are compatible with a model wherein interaction of MDA-9/syntenin with c-Src promotes the formation of an active FAK/c-Src signaling complex, leading to enhanced tumor cell invasion and metastatic spread, Src overexpression downregulates alpha3 integrin total protein expression and localization to the cell surface of HCT116 colon cancer cells. This indicates that Src activity may enhance metastasis by altering alpha3 integrin expression., Src and ADAM-17-mediated shedding of transforming growth factor-alpha is a mechanism of acute resistance to TRAIL., Src and Src-associated signaling pathways are activated in relation to hypoxia in neoplasms, TCPTP is a negative regulator of SFK, JAK1 and STAT3 signalling during the cell cycle., KV11 peptide (from human Apolipoprotein A) suppresses angiogenesis and tumor progression by targeting the c-Src/ERK signaling pathways in VEGF induced cells, as a mediator of SF- and Src-stimulated NF-kappaB activity. Finally, the Src/Rac1/MKK3/6/p38 and Src/TAK1/NF-kappaB-inducing kinase pathways exhibited cross-talk at the level of MKK3., Src family kinases mediate betel quid-induced oral cancer cell motility, Data suggest that upon phosphorylation, Src is directly translocated from focal adhesions to membrane ruffles, thereby promoting formation of new adhesion complexes., the c-Src-Rac1-p38 MAPK pathway is required for activation of Akt in response to radiation and plays a cytoprotective role against radiation in human cancer cells, Mechanical wounding induces significant ROS generation at the wound edge which, in turn, induced ligand-independent KGFR and FRS2 activation via c-Src kinase signaling., HINT1 up-regulates cellular levels of p27(KIP1) by two mechanisms, Nef regulates the NADPH oxidase p47(phox)activity through the activation of the Src kinases and PI3K, S100B interacts with Src kinase, thereby stimulating the PI3K/Akt and PI3K/RhoA pathways., Rho mediates various phenotypes of malignant transformation by Ras and Src through its effectors, ROCK and mDia [review], Presenilin 1 affects focal adhesion site formation and cell force generation via c-Src transcriptional and posttranslational regulation, Increased PRL1 expression results in activation of Src and ERK1/2, which stimulates MMP2 and MMP9 production, leading to increased cell migration and invasion., Sustained Src inhibition results in signal transducer and activator of transcription 3 (STAT3) activation and cancer cell survival via altered Janus-activated kinase-STAT3 binding., These results suggest that SFK trafficking is specified by the palmitoylation state in the SH4 domain., P-selectin cross-links PSGL-1 and enhances neutrophil adhesion to fibrinogen and ICAM-1 in a Src kinase-dependent, but GPCR-independent mechanism., beta-arrestins and c-Src are implicated in the activation of Akt in response to ghrelin through the GHS-R1a, the signal transduction pathways mediated by c-Kit/D816V are markedly different from those activated by wild-type c-Kit and altered substrate specificity of c-Kit circumvents a need for Src family kinases in signaling of growth and survival, activated c-Src played a critical role in the HBx-induced epithelial-to-mesenchymal transition in hepatoma cells., mutant EGFR-Src interaction and cooperativity play critical roles in constitutive engagement of the downstream signaling pathways that allow NSCLC-associated EGFR mutants to mediate oncogenesis., phosphorylation by Src enhances RhoGDI2 metastasis suppression and loss of Src relieves metastasis suppression in tumor, Diesel particle-induced transcriptional expression of p21 involves activation of EGFR, Src, and Stat3, AZD0530 inhibited tumor growth in 4/10 xenograft models tested and dynamically inhibited in vivo phosphorylation of Src substrates paxillin and FAK in both growth-inhibition-resistant and -sensitive xenografts, c-Src enhances RIG-I-mediated signaling, acting at the level of TRAF3, Data reveal a multicomponent kinase signaling pathway downstream of integrin-matrix interactions and Cdc42 activation involving PKCepsilon, Src, Yes, Pak2, Pak4, B-Raf, C-Raf and ERK1/2 to control EC lumen formation in 3D collagen matrices., Activation of ErbB2, but not ErbB1, increases PTP1B expression, and increased expression of PTP1B activates Src and induces a Src-dependent transformed phenotype., Study showed that 28% of patients with AIPC exhibited an increase in SFK activity in prostate cancer tissue, these patients had significantly shorter overall survival, and activated SFK expression correlated with the presence of distant metastases., SFK and cortactin constitute an important signaling pathway that functionally links E-cadherin adhesion and the actin cytoskeleton, EGFR-mediated sustained activation of Src intestinal epithelial cancer cells confers anoikis resistance at least in part through a consequent sustenance of Fak-Src interactions and MEK/Erk activation, Direct binding of toxin A to Src, independent of any effect on protein tyrosine phosphatase or Rho glucosylation, inhibits Src kinase activity followed by FAK/paxillin inactivation, Insights into the mechanism of how a splice variant linked to clinical agressiveness in breast cancer causes increased activity of ADAM15B., PTPalpha acts as an adaptor to mediate functional links between focal adhesions and the endoplasmic reticulum that enable IL-1-induced Ca2+ signaling., Data show that overexpression of shrew-1 leads to preformation of an E-cadherin/EGF receptor/HER2/src-kinase/shrew-1 signaling complex and accelerated E-cadherin internalization., UNC80 functions as a scaffold for Src kinases in NALCN channel function., these results strongly suggest the importance of MSK1 and H3 phosphorylation in cell transformation by v-Src., Proteins beta3 integrin, Vav3, Plekhm1, and Src, implicated in attachment defects, had normal exon sequences in a new type of osteopetrosis., docking of the c-src SH2 domain to phosphorylated guanylyl cyclase C results in colocalization and further activation of c-src., MPP2 interacts with c-Src in cells to control c-Src activity and morphological function., a mechanism linking EGFR signaling with Fyn and Src activation to promote glioblastoma progression and invasion in vivo, Data indicate that MetAP2 expression and pp60c-src phosphorylation were decreased in NC2213 treated cells., pH 6.6 activates Src kinases, resulting in tyrosine phosphorylation of E-cadherin and p120ctn and a weakening of the association of E-cadherin with p120ctn and contributing to the instability of E-cadherin at adherens junctions, LASP-1 translocation to the cytoskeleton of activated platelets correlates with LASP-1 phosphorylation at tyrosine 171 by Src-kinase, Role of Src kinase activity in adhesion and chemotaxis in Waldenstrom macroglobulinemia., The aim of the current study was to assess the expression levels of c-Src and phosphorylated Src kinase in human breast cancers and to establish if these are linked to oestrogen receptor, progesterone receptor, and HER2 status or patient survival., RACK1, partly by inhibiting Src, promotes mitochondrial cell death and blocks Akt-mediated cell survival., Activated c-Src binds, phosphorylates, and redistributes ADAM12-L to specific sites at the cell periphery, which may in turn promote signalling mechanisms regulating cellular processes with importance in cancer., These findings suggest roles for emerin as a downstream effector and signal integrator for tyrosine kinase signaling pathway(s) at the nuclear envelope., Results suggest a novel mechanism by which cofilin is regulated by v-Src through tyrosine phosphorylation that triggers the degradation of cofilin through ubiquitination-proteosome pathway and reducing cellular F-actin contents and cell spreading., The mechanism by which alpha6beta4 enhances S100A4 expression involves Src, Akt, and NFAT., Results link Cdk5 to Rho-ROCK signaling via Src and p190RhoGAP and implicate Cdk5 in the regulation of cell contraction, attachment, and migration., Migfilin interacts with Src and contributes to cell-matrix adhesion-mediated survival signaling, CoxII can be phosphorylated by EGFR and c-Src, and EGF stimulation reduces Cox activity and cellular ATP, an event that is dependent in large part on EGFR localized to the mitochondria., Abl interactor 1 regulates Src-Id1-matrix metalloproteinase 9 axis and is required for invadopodia formation, extracellular matrix degradation and tumor growth of human breast cancer cells, Basal levels of active Src in colonic epithelial cells from patients with inflammatory bowel disease were markedly reduced compared to control patients., analysis of reciprocal regulation of c-Src and STAT3 in non-small cell lung cancer, Phosphorylation of iNOS by Src plays an important role in the regulation of iNOS and nitric oxide production and hence could account for some Src-related roles in inflammation and cancer., Study shows that transient activation of Src causes an epigenetic switch in which nontransformed MCF10A cells are converted into mammospheres that can be propagated for many generations in the absence of the initiating signal., the phosphorylation of Gab1 by c-Src is important for hepatocyte growth factor -induced DNA synthesis, Macroscopic currents from HEK 293 cells expressing murine BK channel alpha-subunits (mSlo) are acutely potentiated following alpha5beta1 integrin activation., The protein-tyrosine kinase c-src control Jak2 activation in response to prolactin through a tyrosine kinase-independent mechanism., These results demonstrated the involvement of Src and its interaction with PI3K in E. coli K1 invasion of human brain microvascular endothelial cells ., Rac activation by mechanical forces is rapid, direct and does not depend on Src activation, the c-Src/Cas/BCAR3 signaling axis is a prominent regulator of c-Src activity, which in turn controls cell behaviors that lead to aggressive and invasive breast tumor phenotypes, The findings presented in this study show that mutant EGFRs undergo aberrant traffic into the endocytic recycling compartment which allows mutant EGFRs to engage in a preferential interaction with Src, a critical partner for EGFR-mediated oncogenesis., Results show that disruption of E-cadherin junctions and enhancement of cell invasion by beta-estradiol stimulation was mediated by NO-dependent activation of c-Src., GD3 has a role in hypoxia susceptibility by disabling the c-Src/NF-kappaB survival pathway resulting in lower Mn-SOD expression, Thrombin-induced Src activation preceded JAK2 activation, which occurred simultaneously in normal and pathological platelets., RhoGDI2 is associated with c-Src in bladder tumors, where the expression of both is diminished as a function of stage. c-Src binds to and phosphorylates RhoGDI2 resulting in enhanced metastasis suppressive potency. Review., a novel regulatory mechanism of c-Src synthesis mediated by an IRES element, which exhibits enhanced activity during cellular stress and is likely to cause c-Src overexpression during oncogenesis and metastasis., 15(S)-HETE-induced angiogenesis requires Src-mediated Egr-1-dependent rapid induction of FGF-2., tyrosine phosphorylation of RUNX3 by activated Src is associated with the cytoplasmic localization of RUNX3 in gastric and breast cancers, Src induces expression of carbonic anhydrase IX via hypoxia-inducible factor 1., v-Src transformation has a role in aggressive tumor behavior in human cancer, Reduced proliferative activity in endometriotic epithelia seems to be related to the reduced expression of SRC-1., These data indicate that Src protein, along with other proteins, are important signal proteins that are responsible for the transfer of signals from activated integrins to the cytoskeleton and thus mediate the endocytosis of Neisseria meningitidis., Integrin alpha5 serves as a key mediator of Src and ErbB2-survival signaling in low adhesion states, which are necessary to block the pro-anoikis mediator Bim., c-Src modulation and ATF3 activity may contribute to differential regulation of IRF-3- versus IRF-5-mediated gene expression, Increased expression of PGE2 in the lung tumor microenvironment may initiate a mitogenic signaling cascade composed of EP4, betaArrestin1, and c-Src which mediates cancer cell migration., The data suggest an important role of Src/PKG-Ialpha interaction in promoting DNA synthesis/cell proliferation in human ovarian cancer cells., Oxidative stress activates FAK and accelerates cell migration in an intestinal epithelium by a PI3 kinase- and Src kinase-dependent mechanism., Present study aimed to evaluate by immunohistochemistry the clinical significance of FAK and Src expression in 108 patients with benign and malignant thyroid lesions., Data show that the FAK and Src immunohistochemical expression was associated with certain clinicopathological parameters that are crucial for the patients' management., elevated Src family kinase activity is sufficient to induce imatinib resistance through a mechanism that may involve phosphorylation of Bcr-Abl, hPEBP4 inhibits proteasome-dependent ERalpha degradation through the Src pathway., study demonstrates, for the first time, that GCS upregulates MDR1 expression modulating drug resistance of cancer. GSLs, in particular globo series GSLs mediate gene expression of MDR1 through cSrc and beta-catenin signaling pathway, Cross-talk between serine/threonine protein phosphatase 2A and protein tyrosine phosphatase 1B regulates Src activation and adhesion of integrin alphaIIbbeta3 to fibrinogen., microexons provide a mechanism for the control of tissue-specific interactions of ITSN1 and Src with their partners., Data show that c-Src suppression by PP2 or siRNA reversed the mesenchymal-like phenotype in MDA-MB-231 cells., c-Src was expressed in malignant melanoma, squamous cell carcinoma and basal cell carcinoma type skin neoplasms., Data illustrate the importance of a coordinated signaling between Src PTKs, ERK1/2, and JNK during pIgR-mediated uptake of pneumococci by host epithelial cells., Data indicate that that a constitutively active transforming form of Src, the E378G mutant, as well as v-Src enhance ADAM17-mediated shedding of the EGFR ligand TGFalpha., Src-mediated phosphorylation of Tyr110 on NoxA1 and of Tyr508 on Tks4 blocks their binding and decreases Nox1-dependent reactive oxygen species generation and induces the formation of functional invadopodia., c-Src differentially regulates the functions of microtentacles and invadopodia., aldehyde dehydrogenase 1 has a role in the antitumor effect of the Src inhibitor dasatinib, These results suggest that heme actively interacts with Jak2 and Src and alters their conformation., Data show E-cadherin molecular dynamics in vivo following perturbation of integrin signaling by inhibiting focal adhesion kinase (FAK) and Src., Src pathway and EGFR pathway play different roles in the proliferation of cervical cancer cells and PP2 efficiently reduces cervical cancer cell proliferation by reduction of both Src and EGFR activity., UGT2B7 substrate selection is not fixed but varies depending upon the tyrosine kinases that carry out its required phosphorylation, These results support an important potential role of FAK-Src signalling in endometrial malignant disease progress, Denbinobin inhibits Src-mediated signaling pathways involved in controlling breast cancer migration and metastasis., MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src., Dsg3, as an up-stream regulator of Src activity, helps regulate adherens junction formation through its interaction with E-cadherin, Results indicate that Cbp is required for the Csk-mediated inactivation of c-Src and may control the promotion of malignancy in NSCLC tumors that are characterized by c-Src upregulation., SHP-2 as an essential component of tumor suppression and anoikis mediated by SIRPalpha1 in human breast carcinoma cells as well as in v-Src-transformed cells., Small interfering RNA knockdown of Src within ANDV-infected endothelial cells resulted in decrease in endothelial cell permeability., activity in desmoid tumors variable, Evidence for a role of Src in the regulation of basal proliferation as well as in basal and TGF-ss1-mediated cell motility but not epithelial-to-mesenchymal transition in TGF-ss-responsive pancreatic (tumor) cells., Collectively, these data provide evidence that Src kinase is an important mediator of signaling events that regulate the appropriate sorting of reovirus particles in the endocytic pathway for disassembly and cell entry., Our findings suggest a novel mechanism by which an EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion, Study observed that CREB was phosphorylated following transactivation of EGFR by c-Src in EV71-infected cells., Findings are consistent with the emerging role of proteasome-mediated proteolysis in the gene-regulating process and indicate that the ligand-dependent down-regulation of SRC-1 is critical for PR transcriptional activity., findings suggest that TCTP induces tumorigenesis through distinct multicellular signaling pathways involving Src-dependent EGFR transactivation, ROS generation and MMP expression, TNC could induce EMT-like change showing loss of intercellular adhesion and enhanced migration in breast cancer cells, associated with FAK phosphorylation by SRC, p130Cas, Src and talin function in both oral carcinoma invasion and resistance to cisplatin., c-Src proto-oncogene tyrosine-protein kinase plays a biologically significant role in ovarian cancer growth and might represent an important target, activates Abl to augment Robo1 expression in order to promote tumor cell migration, ACK1 is not autoinhibited but requires Src for activation., SRC-1 can promote breast cancer metastasis by directly enhancing ITGA5 expression, Findings suggest that the miR-99a-mTOR/FGFR3 pathway is crucial for controlling tumor growth in a wide range of human cancers that harbor upregulation of the Src-related oncogenic pathways., c-Yes regulates specific oncogenic signalling pathways important for colon cancer progression that is not shared with c-Src., results provide new evidence that the activation of Src/Smad1 signaling pathway plays a key role in the development of glomerulosclerosis in experimental glomerulonephritis, Melanoma cells show remarkable resistance to Cav-1 disassembly, together with persisting cell signal activity, being Src and Cav-1 crucial modulators of Rho GTPases., High expression of either Y416Src or Y527Src was significantly correlated with poor overall survival in breast cancer patients, Src-Trask signaling and Src-focal adhesion signaling inactivate each other, constituting two opposing modes of phosphotyrosine signaling that define a switch underlining cell anchorage state., transactivation of c-Met on Axl or PDGFR-alpha in vitro was through a ras- and Src-independent activation of mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK/ERK) pathway, Phosphorylation of Src, but not over-expression, plays a pivotal role in proliferation and invasion of NSCLC cell lines in vitro., c-Src inactivation via SKI-606 reduces renal epithelial cell-matrix adhesion, proliferation, and cyst formation in autosomal dominant polycystic kidney disease., Combination of Src kinase inhibitor KX-01 with tamoxifen may present a promising new strategy for clinical management of ERalpha positive breast cancer., cPLA(2)-dependent AA release is required for VEGF-induced Src-PLD1-PKCgamma-mediated pathological retinal angiogenesis, These findings demonstrate the effectiveness of simultaneous targeting of Src and the downstream signaling partners Stat3 and/or cMyc to inhibit the growth and oncogenic properties of a human cancer cell line., Evidence is presented for the nuclear presence of a functional heteromeric complex of epidermal growth factor (EGFR), Src and the Signal Transducer and Activator of Transcription (Stat)3 proteins in pancreatic cancer cells., an essential role of calmodulin in mediating Fas-induced FADD-independent activation of Src-ERK signaling pathways, which promote survival signaling in pancreatic cancer cells., Data suggest that thymidylate synthase (TS) and Src may belong to a common pathway that bears prognostic significance in NSCLC, and that Src represents a potential target to improve the efficacy of TS-inhibiting agents., Results suggest that a HIF-regulated VHL-PTP1B-Src signaling pathway determines the sensitivity of RCC to Src inhibitors., Manipulation of EMP2 levels in endometrial cancer cells regulates the phosphorylation of FAK and Src, and promotes their distribution into lipid raft domains., Studies indicate that administration of SFK inhibitors in combination with paclitaxel could improve treatment for cancers., The inhibited viability of HeLa cells caused by knockdown of c-SRC is associated with the decreased content of p-STAT3 protein., Down-regulation of src is associated with autism., c-src is a CD24-activated mediator that promotes integrin-mediated adhesion and invasion, and suggest a mechanism by which CD24 might contribute to tumor progression, Suppression of E-cadherin function drives the early stages of Ras-induced squamous cell carcinoma through upregulation of FAK and Src., the active state of c-Src, p-Tyr416-c-Src, may serve as an independent prognostic marker of patient survival in hepatocellular carcinoma, The transformed cells were tumourigenic in nude mice, suggesting that RPTPalpha245-induced activation of Src in the human tumours may have contributed to carcinogenesis., Data show that the signaling events that accompany the CDCP1 tyrosine phosphorylation observed in cell lines and lung tumors may explain how the CDCP1/SFK complex regulates motility and adhesion., Data suggest that targeting Src kinase with a combination of dasatinib and oxaliplatin may be an attractive approach for mucinous ovarian carcinoma., c-Src might be suggested as a bio-marker predicting metastasis sensitivity patterns to HDAC inhibitors., We propose paxillin as a novel cellular target for converging H. pylori-induced EGFR, FAK/Src, and PI3K/Akt signaling to regulate cytoskeletal reorganization and IL-8 production in part, thus contributing to the H. pylori-induced diseases., the nongenomic PI3K signaling pathway plays a role in estrogen/hERalpha-stimulated hSlo1 gene expression; whereas c-Src activity leads to hSlo1 gene tonic repression independently of estrogen, likely through ERK activation., Non-cysteine linked MUC1 cytoplasmic dimers are required for Src recruitment and ICAM-1 binding induced cell invasion., These data suggest Src-stimulated IRTKS phosphorylation is essential for its function in cell motility., Ligand-dependent corepressor acts as a novel androgen receptor corepressor, inhibits prostate cancer growth, and is functionally inactivated by the Src protein kinase., TfR1 is a signaling molecule and tyrosine phosphorylation at position 20 by Src enhances anti-apoptosis and potentiates breast cancer cell survival., Cell surface HSP90 promotes human prostate cancer cell invasion through FAK/c-Src signaling., Express path analysis identifies a tyrosine kinase Src-centric network regulating divergent host responses to Mycobacterium tuberculosis infection., The expression of SRC-1 is correlated with the growth of LNCap cells; its high expression in androgen-independent prostate cancer cells may be involved in the progression to androgen-independence., results provide evidence that CD24 can regulate cell invasion via TFPI-2 and suggests a role of c-Src in this process, Findings suggest that large HBsAg (LHBs) promotes tumorigenesis of hepatoma cells by triggering a PKCalpha/Raf1 to Src/PI3K/Akt signaling pathway, revealing novel insights into the underlying mechanisms of HBV-associated hepatocarcinogenesis., analysis of cellular settings mediating Src Substrate switching between focal adhesion kinase tyrosine 861 and CUB-domain-containing protein 1 (CDCP1) tyrosine 734, Src kinase activity downregulates C/EBP-delta protein but not mRNA levels through a SIAH2 E3 ligase-dependent mechanism., The expression of Src protein is significantly associated with the progression, recurrence, and prognosis of oral squamous cell carcinoma in Taiwan., c-Src is capable of phosphorylating tyr residues of c-Fos whereas the phosphatase TC45 T-cell protein-tyr phosphatase (TC-PTP) dephosphorylates them, human PDZ-cellular ligands of NS1 protein, Lymph node positivity correlated with cytoplasmic c-Src tumour expression levels (P < 0.001)., The effect of gemcitabine-induced cytotoxicity was markedly increased in the psiRNA-c-Src group (P<0.05)., K562 exosomes induced dasatinib-sensitive Src phosphorylation and activation of downstream Src pathway proteins in human umbilical endothelial cells., Trihydrophobin 1 phosphorylation by c-Src regulates MAPK/ERK signaling and cell migration., Fibronectin induces endothelial cell migration through beta1 integrin and Src-dependent phosphorylation of fibroblast growth factor receptor-1 at tyrosines 653/654 and 766., c-Src and IL-6 inhibit osteoblast differentiation and integrate IGFBP5 signalling, Data show that EphrinB1, a PTPN13 substrate, interacts with ErbB2, and Src kinase mediates EphrinB1 phosphorylation and subsequent MAP Kinase signaling., combined inhibition of MEK and SRC is a promising approach to improve the efficacy of targeting the ERK/MAP kinase pathway in melanoma, Src kinase inhibition led to a decrease in mitochondrial respiration via a specific decrease in complex I activities which is associated with a lower phosphorylation of the complex I subunit NDUFB10., EGFRvIII (also known as DeltaEGFR and de2-7EGFR), a constitutively active EGFR mutant that is frequently co-overexpressed with EGFR in human glioblastoma, promotes tumorigenesis through Src family kinase (SFK)-dependent phosphorylation of Dock180., In NEDD9-overexpressing melanoma cells, inhibition of Src with dasatinib results in a switch from Rac-driven elongated, mesenchymal-type invasion to ROCK-dependent rounded, amoeboid invasion, activation of the Src family members and downstream signalling proteins are associated with a good prognosis in transitional cell carcinoma of the bladder, and activated Src has a positive relationship with RhoGD12., A selective SFK inhibitor inhibited Src family kinase activity., These data support novel observations that, in human colon cancer cells, Src-mediated cross talk between aryl hydrocarbon and EGFR results in ERK1/2 activation, thereby stimulating cell proliferation., c-Src only phosphorylated H. pylori EPIYA-C and EPIYA-D., SRC, c-MET and CRK play a key role in gastric carcinogenesis by modulating CagA signal transductions and interaction between CRK gene and phytoestrogens modify gastric cancer risk, Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik., the activation of Hck, Lyn and c-Src by Nef is highly conserved among all major clades of HIV-1, Integrin b1/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial cells., Studies indicate Src family of protein tyrosine kinases (SFKs) lead to uncontrolled cell proliferation and cancers, and Src kinase inhibitors were developed to block cell proliferation signal transductions for cancer therapy., Data show that the Notch-1-Furin interaction is regulated by the non-receptor tyrosine kinase, c-Src., Data indicate a potential role of focal adhesion kinase (FAK) and Src signaling in mobile tongue squamous cell carcinoma (SCC), rendering their small-molecule tyrosine kinase inhibitors as possible treatment strategy in tongue cancer chemoprevention., Src-mediated caspase-8 phosphorylation stimulates Src phosphorylation at Tyr-416 via the linkage of Src SH2 domain with phosph-Tyr-380 site of caspase-8., Data indicates that 2B15 requires regulated phosphorylation by both PKCalpha and Src, which is consistent with the complexity of synthesis and metabolism of its major substrate, DHT., activation of alpha7 by ZP leads to SFK-dependent EGFR activation, Ca(2+) influx, and the acrosome reaction, analysis of Syk/Src pathway-targeted inhibition of skin inflammatory responses by carnosic acid, EGFR and Src activity contribute to carcinoma cell invasion and metastasis mediated by integrin alphavbeta5 in part by promoting proteolytic cleavage of MUC1 ., Src, Akt, NF-kappaB, BCL-2 and c-IAP1 may be involved in an anti-apoptotic effect in patients with BCR-ABL positive and BCR-ABL negative acute lymphoblastic leukemia., Bradykinin enhances cell migration in human prostate cancer cells through B2 receptor/PKC delta/c-Src dependent signaling pathway., c-Src has an essential role in mediating the growth pathways of ER-negative breast cancer cells. It controls estrogen action in ER-positive long-term estrogen-deprived resistant cells., A previously unidentified 70-kDa SRC-1 proteolytic isoform is highly elevated both in the endometriotic tissue of mice with endometriosis and in endometriotic stromal cells biopsied from patients with endometriosis., The interaction between HGF and c-Met increases OPN expression in human osteoblasts via the PI3K, Akt, c-Src, c-Jun, and AP-1 signaling pathway., c-Src but not Fyn promotes proper spindle orientation in early prometaphase, c-Src expression is a potential independent predictor of poor prognosis in breast cancer patients with bone metastasis., results provide evidence that CD24 regulates STAT3 and FAK activity and suggest an important role of Src in this process, A cooperative interplay between FAK, Src and cortactin enables endocytosis of N. meningitidis into host cells., Involvement of c-Src tyrosine kinase upstream of class I phosphatidylinositol (PI) 3-kinases in Salmonella Enteritidis Rck protein-mediated invasion., Data show that EGFR activation leads to a pronounced src-mediated tyrosine phosphorylation of CIN85 that subsequently influences EGFR ubiquitination., ERalpha phosphorylation at Y537 by Src triggers E6-AP-ERalpha binding, ERalpha ubiquitylation, promoter occupancy, and target gene expression., The Epstein-Barr virus protein LMP1, which lacks the canonical ITAM required for Syk activation, can nevertheless activate Syk, and the Src kinase Fyn, resulting in downstream c-Cbl and PI3K/Akt activation., Src functions as a switch of EGF signaling depending on concentrations of EGF, AnxA2 has a role in EGFR-Src membrane bound signaling complex and ligand induced activation of downstream signaling pathways, Knocking down low molecular weight protein tyrosine phosphatase (LMW-PTP) reverts chemoresistance through inactivation of Src and Bcr-Abl proteins, Src family kinases, PI3 kinase and protein kinase C synergize to mediate Gq-dependent platelet activation, in human colon cancer cells Src-mediated cross-talk between FXR and EGFR modulates ERK phosphorylation, thereby regulating intestinal cell proliferation and tumorigenesis., These results suggest that folic acid might inhibit endothelial cell migration through inhibiting the RhoA activity mediated by activating the FR/cSrc/p190RhoGAP-signaling pathway., Data indicate that focal adhesion kinase (FAK) activation and cell migration require Src, Gi/Go, COX-2 and LOXs activities., Rap1 can induce cell adhesion and stimulate an accelerated rate of cell spreading through mechanisms that bypass the canonical FAK-Src-Paxillin signalling cascade, Data indicate that BRAF and EGF receptor or SRC family kinase inhibition blocked proliferation and invasion of the resistant tumors., Data suggest that the antitumor effects of Src inhibition in pancreatic cancer may be enhanced through simultaneous inhibition of SHP-2., activation of c-Src protein through phosphorylation at Tyr416 may play a role in the early stages of ovarian cancer development, Src family kinases could play a pivotal role in increasing B cell receptor sensitivity to monomeric antigens and in mediating a rapid response to soluble multimeric antigens of pathogens that can induce spatial BCR clustering., Brk/PTK6 cooperates with HER2 and Src in regulating breast cancer cell survival and epithelial-to-mesenchymal transition., Data indicate protein secretion pathways activated by monosodium urate (MSU) in macrophages, and reveal a novel role for cathepsin B and Src, Pyk2, PI3 kinases in the activation of unconventional protein secretion., the present study demonstrated that Src plays a biologically significant role in tumor proliferation and apoptosis and enhances the cytotoxic effect of temozolomide through AKT supression in glioma., fucoidan is a novel CLEC-2 receptor agonist that activates platelets through a SFK-dependent signaling pathway, DUOX1 plays a central role in epithelial defense responses to infection or injury, by mediating oxidative activation of Src and ADAM17 in response to ATP-dependent P2Y(2)R activation as a proximal step in EGFR transactivation and downstream signaling., Src is identified as a key regulator of phosphoproteomic signalling networks activated in response to beta-adrenergic signalling in cancer cells., Natural killer cell lytic granule convergence, prompted by specific receptor-mediated and soluble cytokine signals, depends on a directly downstream early Src kinase-dependent signal., a truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity, Expression of HPV type 16 E7 resulted in increase in Src and Yes proteins level, but did not alter the level of Fyn., Oroxylin A sensitized anoikis, which underlies distinct glucose-deprivation-like mechanisms that involved c-Src and HK II., results suggested that PTPalpha links activation of epidermal growth factor receptor (EGFR) signaling with Src activation and may provide a novel therapeutic target for treatment of breast cancer., Src controls invasion by controlling the ability of the cell to form long lasting cellular protrusions to enable penetration through tissue barriers, in addition to its role in promoting invadopodia matrix-degrading activity., v-Src inhibits cell proliferation of HCT116 and HeLa S3 cells., HIF1alpha and HIF2alpha activate independent transcriptional programs through SRC that promote metastasis by coordinately regulating cell invasion and ECM remodeling, Src may play a major role in regulating ING1 levels during tumorigenesis in those cancers in which high levels of Src expression or activity are present., results suggest that c-Src suppression by PP2 or siRNAs may regulate the progression of cell cycle through AKT/GSK3beta and ERK1/2 pathways, Data indicate that tissue transglutaminase (TG2) regulates beta-catenin expression and function in ovarian cancer (OC) cells and define the c-Src-dependent mechanism through which this occurs., Data show that macrophages on gastric and colorectal cancer cells migration through epidermal growth factor receptor and phosphorylation of Akt, c-Src and ERK1/2, and led to an increase of RhoA and Cdc42 activity., The H2O2-induced src/PDGFRbeta/SK1 signaling cascade was impaired in nSMase2-deficient fro/fro cells and was rescued by exogenous C2Cer that activated src/PDGFRbeta/SK1., Phospho-Src expression may be considered as a prognostic marker to predict recurrence in cervical squamous cell carcinoma., study showed that PLC-gamma directly binds c-Src through its SH2 domains, and this interaction is necessary for CCh mediated inhibition of NHE3 activity in Caco-2/BBe/NHE3 cells., c-SRC kinase interacts with FLT3 and c-Kit in a phosphorylation dependent manner. This interaction is facilitated through the SH2-domain of c-SRC kinase., Data suggest a treatment rationale for Src- or Ras-activated cancer., Data show Src-inducible association of CrkL with procaspase-8 promotes cell migration., The posttranscriptional regulation of Src contributes to the deregulated cell growth and metastasis in gastric cancer., c-Src dramatically stimulates IRF4 phosphorylation and activity and Y61 and Y124 are two key sites responding to c-Src-mediated activation. Consistently, c-Src is constitutively expressed and active in EBV-transformed cells., SFK stimulates the basolateral K channel activity in DCT1, at least partially, by phosphorylating Tyr(9) on KCNJ10, Active PKCalpha phosphorylates Src to induce PI-3K to phosphorylate AKT that subsequently activates the ERK1/2 cascade to stimulate goblet cell proliferation., High SRC expression is associated with breast cancer brain metastases., Results show a constitutive interaction between Src kinase and beta3 integrin through its SH3 domain and the phosphorylation of tyrosine in beta3 prevents this interaction., Data indicate that the anti-tumor effects of guggulsterone (GS) possibly involve multiple networks including inhibition of FAK, Src, and Jak/STAT signaling., A potential novel mechanism of c-src activation in plasma cell dyscrasia., MBNL142-43 bind the Src-homology 3 domain of Src family kinases (SFKs) via their proline-rich motifs., Spry4 overexpression resulted in decreased integrin beta3 protein levels in a post-transcriptional manner in part by modulating its tyrosine phosphorylation by c-Src, Data indicate that luteolin and quercetin attenuate the phosphorylation of cortactin and Src, disruption of invadopodia generation suppression of matrix metalloproteinase MMP9 secretion, and reduction in metastasis., Src is an inducer of ADAM28 gene expression through the MEK/extracellular signal-regulated kinase and PI3K/mammalian target of rapamycin pathways., Expression of COX-2 and Src correlated significantly with survival in patients with gastric cancer., NEDD9 promotes migration and invasion in cervical carcinoma cells, probably via a positive feedback loop of tyrosine phosphorylation between NEDD9 and FAK or SRC., c-Src and NWASP play key roles in mediating the molecular pathogenesis of low oxygen-induced accelerated brain invasion by gliomas., a novel mechanism by which the interaction between PP2A and Src in the context of caspase-8 activation modulates TRAIL sensitivity in cancer cells., We hypothesize a potential direct or indirect role for SRC, RAF1, PTK2B genes in neurotransmission and in central nervous system signaling processes., DHA not only displaced several raft-associated onco-proteins, including EGFR, Hsp90, Akt, and Src, from the rafts but also decreased total levels of those proteins via multiple pathways, including the proteasomal and lysosomal pathways, Confluence of cultured lung cancer cells dramatically increases STAT3 activation independent of SRC action., ARHGEF5/Src can be considered as a prognostic biomarker and a therapeutic target for patients with resected non-small cell lung cancer ., Together with HK II and Src, mitochondrial DMPK is part of a multimolecular complex endowed with antioxidant and pro-survival properties., Pyk2 and Src are important in CCL18-induced breast cancer metastasis., This study uncovers a novel mechanism where a phosphoinositide-synthesizing enzyme, PIPKIgammai2, functions with the proto-oncogene Src, to regulate oncogenic signaling., Data indicate the role of the c-Src inhibitor to block E2-induced apoptosis and enhance E2-stimulated growth., our results suggest that Src kinase suppresses the apoptotic p53 pathway by phosphorylating HIPK2 and relocalizing the kinase to the cytoplasm., our results demonstrate that breast cancer cells with acquired resistance to lapatinib have a more aggressive phenotype compared with their parental counterpart, and that Src signaling and CXCR4 play an important role in this phenomenon., Data indicate that verapamil suppresses MDR1 and survivin expressions and increases Bim expression via suppression of Src activation., Src kinase mediates the phosphorylation and activation of cortactin induced by MPZL1 overexpression., Pemphigus vulgaris autoimmune globulin induces Src-dependent tyrosine-phosphorylation of PKP3 and its detachment from DSG3., These data demonstrate that activating the Akt/mTOR cascade and inducing PLK-1 or Twist-1 by c-Src activity depends on the direct interaction between TrkA and c-Src., Bufalin as a potent small-molecule inhibitor for SRC-3 and SRC-1., Src controls castration recurrence of CWR22 prostate cancer xenografts., Phosphorylate caspase-7 bu Src at multiple tyrosine sites enhanced its cellular apoptotic effect., Src-mediated ERK reactivation may play a role in a novel gefitinib resistance mechanism in non small cell lung cancer., Cx43 regulates c-Src activity and proliferation in human glioma stem cell., CXCL4 and CXCL4L1 activated p38 MAPK, as well as Src kinase within 30 and 5 min, respectively. Extracellular signal-regulated kinase (ERK) phosphorylation occurred in activated lymphocytes., MICAL-L1-mediated recruitment of EHD1 to Src-containing recycling endosomes is required for the release of Src from the perinuclear endocytic recycling compartment in response to growth factor stimulation., hERG and hEAG channels are regulated by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domain., Data indicate that inhibition of Src activity induces persistent activation of ataxia telangiectasia mutated (ATM)- and Rad3-related (ATR) and check point kinase 1 (Chk1)., the role of EMP2 in the pathogenesis of GBM a, c-Src-mediated signal positively regulates ACER activity in a Ca2+-independent manner., MET inhibitor or SRC inhibitor suppressed phosphorylation of MET and SRC. These results implicate alternative targeting of MET or SRC as rational strategies for reversing cetuximab resistance in colon cancer., This study demonstrates that cyclic stretch disrupts tight junctions and adherens junctions by a JNK2, c-Src, and MLCK-dependent mechanism., We demonstrated that the association and oxidation of c-Src and SHP-1 by ROS are key steps in enhancing OC survival, which are responsible for increased bone loss when ovarian function ceases., Data suggest that Src activates EGFR through the interaction of both Src-EGFR and Src-caveolin-1, and then antagonizes TRAIL-induced apoptosis in gastric cancer cells., Activation of c-Src kinase in tubular epithelial cells induces epithelial-mesenchymal transition through autophagy., Src activation in lapatinib-resistant cells depends on EGFR-dependent rather than on HER2-dependent signaling., Data indicate that Src kinase participates in the regulation of apoptosis through Src/PI-3 K/Akt signaling pathway in Hep-2 cell line., Src activation participates in trastuzumab mechanisms of resistance and indicates poor prognosis in breast cancer., PELP1 exhibits an oncogenic function in colorectal cancer through c-Src upregulation., These data suggest that v-Src attenuates ATR-Chk1 signaling through the inhibition of Rad17-Rad9 interaction., a critical role of flotillin-1 in ROS production mediated by c-Src, SRC is a putative diagnostic marker to differentiate Undifferentiated Pleomorphic Sarcoma from high-grade Leiomyosarcoma, Collectively, these findings establish Src and pro-angiogenic mitogens as critical mediators of endoglin stability and function, over time with physiological levels of receptor phosphorylation, cell surface receptors produced either enhanced or sustained mitogen-activated protein kinase kinase (MEK), Casitas B-lineage lymphoma (c-Cbl), and the pro-oncogene Src activity., Cbl negatively regulates EPO signaling mainly through the proteasome-dependent degradation of Src, and the E3 ligase activity of Cbl and its tyrosine phosphorylation are regulated by Src but not Jak2., The interaction of different CagA variants with the kinase Src, was investigated., Ras-tyrosine 32 serves as an Src-dependent keystone regulatory residue that modulates Ras GTPase activity and ensures unidirectionality to the Ras GTPase cycle., Fluid flow reduced cytokine-induced SRC activities in the plasma membrane, but not in the cytosol., HER2-positive breast cancers from patients who received trastuzumab exhibited a positive correlation in d16HER2 and pSRC abundance, consistent with the mouse genetic results., Compound K inhibits TNF-alpha-induced MMP-1 expression through the inactivation of c-Src/EGFR-dependent ERK/AP-1 signalling pathway, resulting in the inhibition of collagen degradation in human fibroblast cells, HIF-1 and HIF-2 directly activate the expression of AXL and GAS6/AXL signaling uses lateral activation of the met proto-oncogene (MET) through SRC proto-oncogene nonreceptor tyrosine kinase to maximize cellular invasion., these findings reveal a novel role for Src/FAK pathway kinases in antineoplastic drug resistance, miR-1280 is a tumor suppressor in melanoma via inhibition of the Src signaling pathway., Since Ruxolitinib is a relatively small inhibitor and there is sizeable cavity between Ruxolitinib and c-Src ligand-binding pocket, we propose to modify Ruxolitinib to develop more potent inhibitors to c-Src, These results demonstrated that S1P-induced COX-2 expression and PGE2 /IL-6 generation was mediated through S1PR1/3/c-Src/PYK2/p42/p44 MAPK- or JNK1/2- and S1PR1/3/c-Src/p38 MAPK-dependent AP-1 activation., kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch downstream of focal adhesion kinase in the integrin outside-in signaling circuit controlling cell migration and proliferation, The absence of MIM led to PTPdelta-mediated activation of SRC., Membrane AR activation regulates late expression and/or activity of the tumorigenic gene products c-Src, GSK-3beta. and beta-catenin, These results indicate that pathologic activation of Src is a potential mechanism of acquired resistance to ERBB2 inhibition in ERBB2-amplified gastroesophageal cancer., Eps8 is a crucial mediator of Src- and FAK-regulated processes., Findings suggest that polyomavirus middle T-antigen (PyMT) activates the Hippo pathway tumor suppressor Lats in a Src-dependent manner., Results indicate that oncogenic Src may contribute to Fn14 overexpression in solid tumors, and that Src mediated cell invasion could potentially be inhibited with Fn14- targeted therapeutics., CD147 has a role in promoting Src-dependent activation of Rac1 signaling through STAT3/DOCK8 during the motility of hepatocellular carcinoma cells, FVB murine prostate epithelium was transduced with oncogenic v-Src., role for beta1-integrin in stretch-induced renal fibrosis through the activation of c-Src and STAT3 signaling pathways, reactive oxygen species (ROS) trigger the c-Src kinase-mediated tyrosine (Tyr)-195 phosphorylation of PKP3., Data indicate that CD20 antigen downregulation relies on transcriptional mechanisms in SRC family kinases (SFKs)-dependent transcriptional regulation of CD20., EspJ inhibits autophosphorylation of host Src and phosphorylation of the Src substrates Tir and FcgammaRIIa., Radiation exposure activates SRC induced SLUG expression and causes epithelial-mesenchymal cell transition through phosphatidylinositol 3-kinase/protein kinase B and p38 MAPK signaling., These findings provide a new insight into VEGF and c-Src mode of reaction in triggering destructive repair of osteonecrosis., TGF-beta activates Src in H358 cells largely through a non-canonical redox mechanism., A novel mechanism of regulation of NMHC-IIA activity relying on the phosphorylation of Tyr-158 by Src., performed immunohistochemical staining for total and phosphorylated forms of FAK and Src, to evaluate the role of FAK and Src in the development of premalignant and malignant skin lesions, Src and p-Src can be used as an auxiliary indicator to determine a malignant phenotype of bone tumors, and the combined detection of Src and p-Src may indicate the prognosis of osteosarcoma., prostate cancer cell invasion is stimulated by a rapid but sustained increase in Src activity, mediated non-genomically by cytoplasmic AR, leading to rapid activation and shedding of the laminin protease Matriptase, c-Src signaling modulates osteoblast differentiation at least in part through phosphorylation of Osterix., The existence of an AR-miR-1-SRC regulatory network., WNK4 is a substrate of SFKs and the association of c-Src and PTP-1D with WNK4 at Tyr(1092) and Tyr(1143) plays an important role in modulating the inhibitory effect of WNK4 on ROMK, We conclude that AFB1 may upregulate IRS2 and stimulate lung cancer cell migration through Src, Fer interacted with active c-Src at focal adhesion membranes. Fer tyrosine kinase oligomer mediates and amplifies Src-induced tumor progression., PTP1B inhibited BRK by dephosphorylating Tyr-342, but activated SRC by antagonizing PAG-dependent inhibition by CSK., Results highlight the scaffolding role of the SH3 domain for the c-Src N-terminal intrinsically disordered regions and suggest a connection between the regulatory mechanisms involving the SH3 and Unique domains., carbon monoxide-releasing molecule-2-induced heme oxygenase-1 protein and mRNA levels were inhibited by the inhibitor of c-Src, Src, Syk, IRAK1, and IRAK4 have roles in anti-inflammatory responses mediated by dietary flavonoid Kaempferol, the primary interaction of c-Src with the beta3 tail occurs in its activated state and at a site that overlaps with PPII binding site in its SH3 domain., Thus, Src inhibitors emerge as a new class of drugs able to promote frataxin accumulation, suggesting their possible use as therapeutics in Friedreich's Ataxia, Cell surface GRP78 directly binds and phosphorylates c-Src. As a consequence, c-Src phosphorylated EGFR, promoting the invasion and metastasis of HCCs., These data demonstrate that the p52Shc phosphorylation level is altered by the solution environment without affecting the fraction of active c-Src., these results indicate that biological changes induced by CD44 silencing are mediated by cumulative down-regulation of c-Jun, Sp1, and c-Src in human breast cancer cells., In marked contrast to invadopodia, this degradation does not require the action of Src kinase, Cdc42 or Dyn2. Rather, inhibition of Dyn2 causes a marked upregulation of stromal matrix degradation, This study provides an additional mechanistic link between Angiotensin II and vasoconstriction via SFK-enhanced MLC phosphorylation in smooth muscle cells., SPON1 promotes metastatic progression through Fak and Src dependent pathway in human osteosarcoma., findings suggest that Src, Kindlin-2 and Migfilin together constitute a positive feedback loop that controls Src activity and regulates integrin-mediated cellular func, activation of Src/STAT3/HO-1/autophagy signaling pathway might play a general role in protecting certain subtypes of breast cancer cells from doxorubicin-induced cytotoxicity, Our results demonstrate that SRC-1 promotes HCC progression by enhancing Wnt/b-catenin signaling and suggest that SRC-1 is a potential therapeutic molecular target for HCC., these results indicate that in HCFs, activation of NF-kappaB by c-Src-mediated transactivation of EGFR/PI3K/Akt cascade is required for TNF-alpha-induced VCAM-1 expression., Data show that YY1 transcription factor (YY1) is tyrosine-phosphorylated by Src family kinases, leading to down-regulation of its activity., Src expression showed a significantly positive linear relationship with RANK, suggesting a potential mechanism of the RANKL-RANK axis in regulating breast cancer cell differentiation and antiapoptosis., Src-mediated Y724 phosphorylation in ELMO1 plays a critical role for cell spreading via activation of Rac1, leading to promotion of cell migration., ligand binding to cell surface GD2 induces rapid and transient activation of Src-family kinases, followed by Src-dependent phosphorylation of NMDA-receptor NR2B subunits selectively., Data reveal that introducing mutations in SH3 domain results in reduced Src motility at the cell membrane, both inside and outside of focal adhesions., our integrative approach enabled the discovery of a new model where Src is de-activated in coordination with membrane protrusion, providing important insights into the regulation of endothelial migration and angiogenesis., Data show that c-Src is expressed by Sertoli and germ cells; its activation is required for germ cell adhesion and detachment and it mediates disassembly of Sertoli cell-spermatid junctions during spermatogenesis through an endocytic mechanism.[review], Data suggest that Src kinases inhibitors may act with different mechanisms in non-small cell lung cancer (NSCLC) depending on EGF receptor (EGFR)/Ras protein (Ras) mutational profile., Data show that src kinases (SRC) and mitogen-activated protein kinase kinase 1 (MEK) co-inhibition by saracatinib and PD0325901 respectively can be broadly effective in tumor growth control of a wide panel of non-small cell lung cancer (NSCLC) cell lines., Data suggest 17beta-estradiol stimulates odontoblastic differentiation of dental pulp via coordinated regulation of estrogen receptor alpha, c-Src, and MAP kinase signaling pathways, which may play key role in calcification/regeneration of dentin., Data suggest that tyrosine-phosphorylated CaM (calmodulin) elicits strong up-regulation in ligand-dependent activity of EGFR (epidermal growth factor receptor) in vitro; for these studies CaM was phosphorylated by c-Src (cellular sarcoma kinase)., SRC, LYN and CKB expression or DNA methylation could be useful markers for predicting tumor progression., This study describes a pro-metastatic EGFR/Src-dependent beta4 integrin/FAK complex that is involved in breast cancer malignancy and is a novel therapeutic target for triple-negative breast cancer., regulation of c-Src trafficking requires both microtubules and actin polymerization, and GEF-H1 coordinates c-Src trafficking, acting as a molecular switch between these two mechanisms, Src has a role in priming Pyk2 (but not FAK) phosphorylation and subsequent activation downstream of integrins, Collectively, our data demonstrate that DCMF induces cell migration and promotes wound healing through activation of Src/FAK, ERK, AKT, and p38 MAPK signaling., FGF-2, VEGF-A, and HIV-Tat, may affect the glomerular filtration barrier in HIV+ children through the induction of synergistic changes in Rho-A and Src activity,
OMIM_DISEASE Colon cancer, advanced, somatic,
SP_COMMENT catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate., PTM:Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. The phosphorylated tail interacts with the SH2 domain thereby repressing kinase activity., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily., similarity:Contains 1 protein kinase domain., similarity:Contains 1 SH2 domain., similarity:Contains 1 SH3 domain., subunit:Interacts with DDEF1/ASAP1; via the SH3 domain. Interacts with CCPG1 (By similarity). Interacts with CDCP1, PELP1, TGFB1I1 and TOM1L2. Interacts with the cytoplasmic domain of MUC1, phosphorylates it and increases binding of MUC1 with beta-catenin. Interacts with RALGPS1; via the SH3 domain. Interacts with HEV ORF3 protein; via the SH3 domain.,