Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
The Database for Annotation, Visualization and Integrated Discovery
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SOS Ras/Rho guanine nucleotide exchange factor 2(SOS2) SOS Ras/Rho guanine nucleotide exchange factor 2(SOS2) Related Genes Homo sapiens
CHROMOSOME 14,
CYTOBAND 14q21,
ENSEMBL_GENE_ID ENSG00000100485,
GENERIF_SUMMARY Significant association of single nucleotide polymorphism within three genes--PPARgamma, SOS2, and PCK1--with Alzheimer's disease, was confirmed., Loss of MADD expression resulted in reduced Grb2 and Sos1/2 recruitment to the TNFR1 complex and decreased Ras and MEKK1/2 activation, intracellular Francisella tularensis novicida triggers temporal and early activation of Ras through the SOS2/GrB2/PKCalpha/PKCbetaI quaternary complex; Ras signalling by intracellular F. tularensis is essential for intracellular proliferation in the cytosol, multicenter pharmacogenetic study in children (ages 6-11), We identified two novel genes, SOS2 and LZTR1, associated with Noonan syndrome, thereby expanding the molecular spectrum of RASopathies., Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome,
OMIM_DISEASE Noonan syndrome 9,
SP_COMMENT function:Promotes the exchange of Ras-bound GDP by GTP., online information:Son of sevenless entry, similarity:Contains 1 DH (DBL-homology) domain., similarity:Contains 1 N-terminal Ras-GEF domain., similarity:Contains 1 PH domain., similarity:Contains 1 Ras-GEF domain.,