Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
The Database for Annotation, Visualization and Integrated Discovery
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DAVID Functional Annotation Table
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snail family transcriptional repressor 2(SNAI2) snail family transcriptional repressor 2(SNAI2) Related Genes Homo sapiens
CHROMOSOME 8,
CYTOBAND 8q11,
ENSEMBL_GENE_ID ENSG00000019549,
GENERIF_SUMMARY The SLUG zinc-finger protein represses E-cadherin in breast cancer., Absence of SLUG causes the auditory-pigmentary symptoms in at least some individuals with Wardenburg syndrome type 2., Results suggest that aberrant expression of Snail or Slug may promote tumorigenesis through increased resistance to programmed cell death., induction of Slug by autocrine production of SCF and c-Kit activation plays a key role in chemoresistance of malignant mesothelioma, Tumors with positive Slug expression invaded deeper, had more lymph node metastasis, and had more lymphatic invasion than the tumors with negative Slug expression., SLUG is a negative regulator for BRCA2 gene expression, SLUG levels in the cell regulated the function of cytokeratins 8 and 19 gene promoters., High levels of Snail predict decreased relapse-free survival in women with breast cancer., SLUG is upregulated by dihydrotestosterone and epidermal growth factor, providing a molecular mechanism by which epithelial cell-specific genes are silenced during prostate cancer development and progression., Slug regulates integrin alpha3, beta1, and beta4 expression and cell proliferation in human epidermal keratinocytes, Slug overexpression may contribute to specific cardiac phenotypes and cancer development., These findings support a role of Slug in mediating Raf 1-induced transcriptional repression of occludin and subsequent epithelial to mesenchymal transition., Results suggest that the aryl hydrocarbon receptor participates in Slug induction, which, in turn, regulates cellular physiology including cell adhesion and migration., we provide evidence through yeast two-hybrid and in vitro co-immunoprecipitation analyses that hSLUG does not directly interact with hCtBP1., Data show that SNAI1 and SNAI2 are ectopically expressed in thyroid carcinomas, and aberrant expression in mice is associated with papillary carcinoma development., Ligand-induced Notch activation, through the induction of Slug, promotes tumor growth and metastasis characterized by epithelial-to-mesenchymal transition., Myocardin-related transcription factors are critical mediators of transforming growth factor beta (TGF-beta) 1-induced epithelial-mesenchymal transition.[, Knockdown of SIM2s in MCF-7 breast cancer cells contributed to an epithelial-mesenchymal transition associated with increased slug levels., SLUG binds to the E2-box sequences of the VDR gene promoter and recruits CtBP1 and HDAC1, which results in the inhibition of VDR gene expression by chromatin remodeling., The effect of Etrogen receptor alpha on slug repression is dependent on the overall level of ERalpha, confirming that slug is an estrogen receptor alpha responsive gene., Slug down-regulation facilitates apoptosis induced by proapoptotic drugs in neuroblastoma cells and decreases their invasion capability in vitro and in vivo, Collectively, our data suggest that combined expression of Slug and Snail is required for EMT in cardiac cushion morphogenesis., Slug is an essential component of the pathway leading to EGFR-mediated epithelial outgrowth, These results implicate a novel EGFR/Erk5/Slug pathway in the control of cytoskeleton organization and cell motility in keratinocytes treated with epidermal growth factor., Snail and Slug promote formation of beta-catenin-T-cell factor (TCF)-4 transcription complexes that bind to the promoter of the TGF-beta3 gene to increase its transcription., SLUG-induced epithelial-mesenchymal transition may alter the expression profile of receptor tyrosine kinases, including discoid domain receptors, Factors released by breast cancer cells are able to upregulate Slug expression in vascular endothelial cells., We found upregulation of mRNA for transcription factors Snail, Slug, Twist, and SIP1 in spindle cell carcinoma when compared to squamous cell carcinoma., changes in the Akt/beta-catenin pathway play key roles in the regulation of E-cadherin through the transactivation of the Slug gene in uterine carcinosarcomas., Results indicate that wtp53 and p53 mutants may differentially control cancer invasion and metastasis through the p53-MDM2-Slug pathway., Overexpression of Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer., TGF-beta1 increases Slug via ERK1/2 signaling, and thereby contributes to oral squamous cell carcinoma progression., aids in Wnt/beta-catenin signal transduction in invasive ductal carcinoma of breast, Slug functions as a novel regulator of osteoblast activity and may be considered a new factor required for osteoblast maturation., Data show that elevated Snail expression by Pdcd4 knockdown leads to downregulation of E-cadherin resulting in activating beta-catenin/Tcf-dependent transcription., Coexpression of Snail and Twist correlated with the worst prognosis of hepatocellular carcinoma., Studies suggest a model of hypoxia induced metastasis through expression of HIF-1alpha, and SLUG regulation of MT4-MMP transcription., Data show there was a strong inverse correlation between slug and ERalpha and E-cadherin immunoreactivity in breast cancer cases., Results suggest that SLUG expression is correlated with osteogenic commitment, and is positively regulated by Lef-1 signal in normal human osteoblasts., transcription factors Snail1 and Snail2 repress vitamin D receptor during colon cancer progression, p63 isoforms are regulated by snail and slug transcription factors in human squamous cell carcinoma, Slug gene facilitates apoptosis of fibroblast-like synoviocytes by increasing Puma transactivation., Results suggest that Slug expression is a novel prognostic marker for intrahepatic cholangiocarcinoma with lymph node metastasis., The aggressive stem cell-like phenotype of breast cancer cells is induced by inflammatory cytokine TNF-alpha activation SLUG via NFkB/HIF1a, which is further enhanced by the loss of p53 function., Slug protein is a negative regulator of proliferation of prostate cancer cells, Identified SNAI2/Slug as a regulator of growth and invasion in human gliomas., High slug is associated with extrahepatic hilar cholangiocarcinoma., Data show that the proto-oncogene c-Myb controls Slug transcription in tumor cells of different origin. Such a regulatory pathway contributes to the acquisition of invasive properties that are important for the metastatic process., Data show that mesenchymal to epithelial reverting transition, which is mediated through regulation of Slug, is a clinically significant phenotype in leiomyosarcoma., Slug is an important modulator of apoptosis, growth and invasion in esophageal adenocarcinoma, Slug may play an important role in the invasion and metastasis of salivary adenoid cystic carcinoma, and has the potential for being one of the strong invasion and metastasis indicators at presentation of such patients., Demonstrate that twist, snail and slug have inappropriate expression in bladder carcinoma and that this may play a part in the progression of human bladder carcinoma., SLUG inhibits the expression of UbcH5c directly through chromatin remodeling and thus, among other downstream effects, elevates the level of cyclin D1, Slug-specific siRNA significantly reduced tumor growth by approximately 60% and inhibited metastasis and angiogenesis in a xenograft mouse model., These findings indicate that IKKalpha contributes to the tumor-promoting function of the TGFbeta-SMAD signaling pathway in particular cancers., rAAV2-Slug siRNA transfection resulted in downregulation of the levels of Slug in tumor cells., Results show a positive correlation between CXCL12 signaling and Slug activity, thus corroborating the role of these two proteins in bone cells., results show that Twist1 needs to induce Snail2 to suppress the epithelial branch of the EMT program and that Twist1 and Snail2 act together to promote EMT and tumor metastasis, Expression of Snail2 in long bone osteosarcomas correlates with tumour malignancy., in patients with gastric caancer, expression of E-cadherin and that of Slug were associated with tumor properties, including lymph node metastasis, stage, lymphatic invasion, and venous invasion, as well as with prognosis, Slug expression in our panel of colon cancer cell lines was inversely correlated with E-cadherin expression and enhanced migration/invasion, HAb18G/CD147 promotes epithelial-mesenchymal transition through TGF-beta signaling and is transcriptionally regulated by Slug.(, transcriptional activity of ZEB1 is increased by Slug, suggesting a hierarchical organized expression of epithelial mesenchyme transition (EMT) transcription factors through directed activation, triggering an EMT-like process in melanoma., Slug down-regulation promotes cell apoptosis and decreases invasion capability in vitro and in vivo. Slug inhibition may represent a novel strategy for treatment of metastatic esophageal squamous cell carcinoma., ERalpha and ERbeta may act in opposite directions to regulate the Slug-E-cadherin pathway and to affect invasiveness of nonfunctional pituitary adenoma, Slug-silenced cells changed in morphology, decreased in their migration ability, increased Sox9 and Sox5 and decreased Sox6 and STAT1 expression, down-regulation of Claudin-7 and overexpression of Slug in lung squamous cell carcinoma and adenocarcinoma, Snai2 plays major roles in EMT and the progression of SCCOT and may serve as a therapeutic target for patients at risk of metastasis., elevated levels of slug were accompanied by down regulation of E-cadherin in adenocarcinoma cells., Slug expression in UM-SCC-38 cells induces a mesenchymal phenotype and results in increased motility., Slug protein expression level was negatively correlated with pathological tumor stage, suggesting that Slug was down-regulated in advanced renal cell carcinoma., Overexpression of Snail, Slug, and dysadherin and activation of Wnt and PI3K/Akt signaling was associated with inactivated E-cadherin in the spindle cells of monophasic fibrous synovial sarcomas., a global view of the impact of Snail and Slug expression, SLUG-mediated migration and invasion in prostate cancer cells, Increased expression of Slug was observed in 18.2% of primary NSCLC tumors. Overexpression of Slug in stage I NSCLC was associated with a worse overall survival and correlated with a shorter recurrence-free survival., The known, precise and consistent gene composition of this cancer mesenchymal transition signature provides unique opportunities for shedding light on the underlying mechanisms of cancer invasiveness, ROCK cooperated with ET-1/ET(A)R to promote EMT of human ovarian carcinoma cells through upregulation of SLUG mRNA, Results demonstrate differential effects of Snail and Slug in pancreatic cancer and identify the interplay between Rho signaling and beta1-integrin that regulates the scattering and migration of Snail- and Slug-expressing pancreatic cancer cells., None of 20 ordinary glioblastomas showed Slug expression in >10% neoplastic cells., Coexpression of Slug and Sox9 promotes the tumorigenic and metastasis-seeding abilities of human breast cancer cells and is associated with poor patient survival, Data indicate that up-regulation of Slug was significantly correlated with a higher tumor stage and the E- to N-cadherin switch in bladder cancer cells and tissues., Data suggest that Snail expression could be a reliable independent prognostic factor to predict gastric carcinoma progression, which might open a new avenue for potential clinical intervention with functional Snail expression in gastric cancer patients., Slug is expressed markedly higher while E-cadherin markedly lower in metastatic gastrointestinal stromal tumors., Gene expression signature of the transcription factor SNAI2 and the putative stem cell marker CD44 are strongly correlated and highly expressed in glioblastomas versus lower grade gliomas., This study thus implicates SLUG-induced repression of plakoglobin as a motility determinant in highly disseminating breast cancer., The studies suggest a role for Slug early in the transformation of melanocytes to melanoma cells., Chromatin immunoprecipitation (ChIP) analysis showed that Slug is a target gene of Egr-1., GSK-3beta-mediated phosphorylation of Slug/Snail2 controls its turnover and localization during EMT., There is a reciprocal regulation between Slug and AR not only in transcriptional regulation but also in protein bioactivity, and Slug-AR complex plays an important role in accelerating the androgen-independent outgrowth of CRPC., Slug regulates cyclin D1 expression by ubiquitin-proteasome pathway in PCa cells, Invasiveness was significantly correlated to the increased Slug in tumour cells, as well as to increased ASMA, S100A4, and PDGFRbeta in stromal cells., High Slug and low E-cadherin expression in basal-like breast cancer (BLBC) correlated with histological grade, TNM stage, and lymphatic metastasis. Poor prognosis of BLBC is associated high Slug and vimentin expression and low E-cadherin levels., we have demonstrated strong diffuse expression of SNAI2 and TWIST1 in the majority of anaplastic thyroid carcinomas but not in normal thyroids, thyroid adenomas or well-differentiated thyroid carcinomas, autocrine SPARC maintains heightened SLUG expression in melanoma cells and indicate that SPARC may promote EMT-associated tumor invasion by supporting AKT-dependent upregulation of SLUG., Kruppel-like factor 4, a tumor suppressor in hepatocellular carcinoma cells reverts epithelial mesenchymal transition by suppressing slug expression., Ectopic expression of Snail and Twist contributed to lymph node and disseminated metastasis, respectively, by reducing E-cadherin expression, providing a novel role for Snail and Twist in the progression of colorectal cancer., Findings establish unique functional links between canonical Wnt signaling, Slug expression, EMT, and BRCA1 regulation., The overexpression of SLUG and TWIST with down-regulation of E-cadherin was characteristic findings in hemangiopericytomas and solitary fibrous tumors, but not in meningiomas., These studies suggest that miR-221 expression is, in part, dependent on Slug in breast cancer cells, It might play an important role in the implantation of metastatic foci., These results suggest that FAM3B-258 promotes colon cancer cell invasion and metastasis through upregulation of Slug., Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2., Re-expression of miR-1 may be an effective therapy that prevents cancer malignancy by converting cells from a mesenchymal phenotype to an epithelial phenotype via the downregulation of Slug., In diffuse large B-cell lymphoma, cytoplasmic Slug expression was linked to a favourable disease outcome, whereas nuclear expression of ZEB1 indicated an adverse outcome., SFRP2 appears to interact with Slug to affect the apoptosis of hypertrophic scar fibroblasts, High SLUG expression is associated with lung cancer growth and metastasis., Data indicate that Slug siRNA suppressed the TGF-beta1-induced integrin alpha3beta1-mediated cell migration ability of squamous cell carcinoma HSC-4 cells., Data indicate that SLUG silencing increased the interference of radiation on cell cycle distribution and cell killing by 60 % and 80 % in M79 cells after a 2.4 Gy and 5 Gy radiation dose, respectively., Snail2 promotes osteosarcoma cell motility through remodelling of the actin cytoskeleton and regulates tumor development., miR-182 and miR-203 induce mesenchymal to epithelial transition features and growth factor independent growth via repressing SNAI2 in prostate cells., High SNAI2 is associated with ovarian cancer., Sox2 expression in hepatocellular carcinoma patients correlates with transcription activity of the SLUG promoter region., ANGPTL1 represses lung cancer cell motility by abrogating the expression of the epithelial mesenchymal transformation mediator SLUG., binding of Mdm2 to the Slug mRNA appears to provide a novel mechanism through which Mdm2 promotes tumor progression in a manner independent of the presence of p53., the SNAI2 and miR-203 regulatory loop plays important roles in EMT and tumor metastasis., The staining intensities of Snail and Slug are associated with decreased E-cadherin staining in SCC and this may promote EMT. However, the staining intensities of p53 and p63 are not significantly correlated with the loss of E-cadherin., benzo[a]pyrene regulates the invasive properties of rheumatoid arthritis (RA) fibroblast-like synoviocytes through Slug expression and may provide a a link between smoking and increased progression in RA., Gas6 induced the activation of JNK and ERK1/2 signaling in cancer cells expressing Axl, resulting in the phosphorylation of activator protein-1 (AP-1) transcription factors c-Jun and ATF-2, and induction of Slug., Slug mediates an aggressive phenotype including enhanced migration activity, anoikis suppression, and tumor growth, but increases sensitivity to tubulin-binding agents via the downregulation of betaIII and betaIVa-tubulin in lung cancer cells., Data indicate that pancreatic (pro)enzymes enhanced expression of beta-catenin and E-cadherin and decreased expression of several epithelial-mesenchymal transition (EMT)-associated genes, such as Vimentin, Snail and Slug., slug has a role in a PI3 kinase pathway that promotes endothelial survival via notch activation, slug induced the increase and maintenance of cancer stem cell subpopulation and contributed to vasculogenic mimicry formation eventually., FOXM1 promotes epithelial to mesenchymal transition (EMT) in breast cancer cells by stimulating the transcription of EMT-related genes such as Slug., VAV1 overexpression in both SKOV3 and human ovarian surface epithelial cells demonstrated that its upregulation of an E-cadherin transcriptional repressor, Snail and Slug, was not confined to ovarian cancer cells, high basal levels of Slug prevent the chondrogenic differentiation of human mesenchymal stem cell., Downregulation of SLUG protein expression significantly inhibits growth and invasion of colorectal cancer cells in vitro., MiR-181a regulates the MAPK-Snai2 pathway., Our results show that a Slug-dependent endothelial mesenchymal transition process is involved in bleomycin-induced therapeutic effects on endothelial cells and indicate the potential role of this process in the sclerotherapy of venous malformations., High Slug expression is associated with radioresitance in colorectal cancer., Increased expression of Slug is associated with lymph node metastasis in colorectal cancer., Host Kruppel-like factor 15, Slug, and SPDEF, stimulated the herpes simplex virus type 1 ICP0 promoter more than 150-fold., The Slug/beta-catenin-dependent activation of DNA damage signaling triggered by the hypoxic microenvironment sustains the proinflammatory phenotype of breast cancer stem cells., ETV1 expression is significantly correlated with Snail expression in human gastric tumor samples. In summary, we present data that ETV1 promotes Snail expression to induce EMT-like metastatic progression in gastric cancer., Snai2 is downregulated by glyoxal in a process that causes defective keratinocyte migration, findings indicate that Gas6/Axl regulates tumor invasion through the transcriptional activation of Slug, MiR-204 inhibits epithelial to mesenchymal transition by targeting Slug protein in intrahepatic cholangiocarcinoma cells., Alterations in Slug expression occur in early stages of development of esophageal squamous cell carcinoma and are sustained during disease progression, mutations of MITF, SNAI2 and SOX10 genes are observed in Waardenburg syndrome type II. mutation of the KIT gene and/or heterozygous deletion of the SNAI2 gene result in piebaldism disease(review), Loss of slug expression is associated with breast and lung cancer., the evaluation of HIF-1alpha, MT and SLUG expression in papillary thyroid carcinoma may be useful in predicting the risk of lymph node metastasis and high TNM stage., Altogether, our study uncovered the existence of a novel Akt-HSF-1 signaling axis that leads to Slug upregulation and EMT, and potentially contributes to progression of HER2-positive breast cancer, SLUG and MSX2, transcription factors involved in epithelial-mesenchymal transitions, essential features of gastrulation in development and tumor progression, are important mediators of BMP4-induced differentiation in human embryonic stem cells., SNAI1, SNAI2, SNAI3 show unequal oncogenic potential, strictly correlating with their ability to promote epithelial-to-mesenchymal transition., NOR1 suppresses slug/vimentin expression to inhibit epithelial-mesenchymal transformation in nasopharyngeal carcinoma., Androgen receptor signaling promotes bladder cancer metastasis through Slug mediated epithelial-mesenchymal transition., Results indicate that Slug has multifaceted roles in cancer progression by controlling both epithelial-mesenchymal transition and genome stability., Slug silencing showed a pro-chondrogenic effect, highlighting both its potential use as an alternative to TGFbeta treatment, and the critical role of the Slug TF in determining the fate of hMSCs., High expression of slug was correlated with salivary adenoid cystic cancer., we have shown that miR-1 directly targets the Slug gene in chordoma. Restoration of miR-1 suppressed not only proliferation, but also migratory and invasive activities, and reduced the Slug expression in chordoma cells., Slug promotes survival during metastasis through suppression of Puma-mediated apoptosis., There was no significant difference in SNAI2 mRNA expression in basal cell carcinoma compared to normal skin tissue., Data suggest that macrophages contributed to the decreased expression of E-cadherin by NF-kappaB/Slug protein pathway in hepatocellular carcinomas., Axl exerts the role of tumor metastasis and chemosensitivity through activation of the PI3K/Akt/GSK3beta signaling pathway, which is transcriptionally regulated by Slug., Slug is a functional target of IMP3 in breast cancers, the levels of SNAI2 binding to genomic targets determine the differentiation status of epithelial cells, pregnancy-associated mammary stem cells require a TGF-beta2/alphavbeta3/Slug pathway, Functional studies reveal that p21 and p53 cooperate to facilitate Mdm2-dependent Slug degradation and that this p53 function is mimicked by p53(R273H), a mutant lacking trans-activating activity., A novel role of hTERT in stress hormone-induced ovarian cancer aggressiveness through inducing Slug, providing novel biomarkers and potential therapeutic targets for ovarian cancer., TSP-1 cooperates with FGF-2 and VEGF/VEGFR-1 in determining melanoma invasion and metastasis, as part of a Slug-independent motility program., Modulation of Slug signaling (and MMP-9 expression) by ERK5 knockdown, inhibited tumor invasion in osteosarcoma cells., Slug, a target gene of miR-140, was examined by luciferase assay., Slug influences growth of lung squamous cell carcinomas and has an independent prognostic value in this tumor type., Slug promotes progression of hepatocellular carcinoma by promoting sox2 and nanog overexpression., Inhibition of Slug expression in laryngeal carcinoma cells via knockdown of S100A4 enhances sensitivity to cisplatin., self-renewal versus differentiation of human ESCs (hESCs) in response to Wnt signaling is predominantly determined by a two-layer regulatory circuit involving beta-catenin, E-cadherin, PI3K/Akt, and Slug in a time-dependent manner., CCL21/CCR7 pathway activates signallings to up-regulate Slug pathway, leading to the occurrence of epithelial-mesenchymal transition process in human chondrosarcoma, Notch1 signaling regulates the epithelial-mesenchymal transition and invasion of breast cancer in a Slug-dependent manner., Study shows the ability of Slug to bind E-boxes of ERalpha promoter region, and thereby to suppress de novo ERalpha synthesis contributing to tumor progression in breast and prostate neoplasm and drug resistance as well., SNAI2 expression in selected PCa cells, by regulating their self-renewal, High SNAI2 expression was significantly correlated with Gastric Cancer., SLUG regulates PTEN expression in prostate cancer cell lines., LCN2 plays an important role in promoting cell migration and invasion of prostate cancer by inducing EMT through the ERK/SLUG axis., High SLUG expression is associated with gastric cancer., Slug inversely regulated PUMA and p53 expression in both CNE-2 and CNE-2-RES cells., Consistent with its role as an intermediate filament, vimentin acted as a scaffold to recruit Slug to ERK and promote Slug phosphorylation at serine-87., In glioblastoma cells, SNAI2 was identified as a direct target gene of miR-203. The knockdown of SNAI2 by short hairpin RNA (shRNA) inhibited EMT and drug resistance., SNAI2/SLUG is prognostic of patients' outcome. The strong inverse correlation with ESR1 indicates a significant impact of estrogen receptor pathway regarding these malignant features., Our results show that HOXB13/SLUG and ALX4/SLUG axes are novel pathways that promote EMT and invasion of ovarian cancer cells., we show that SOX2 is a transcriptional target of SLUG. These data establish a novel mechanism of breast tumor initiation involving IMP3 and they provide a rationale for its association with aggressive disease and poor outcome., It plays an important role in not only invasion ability through EMT but also gemcitabine resistance of CD133-positive pancreatic cancer cells., SLUG and TWIST expression in IDC was significant higher in stromal cells., the correlation between FP receptor and Slug was also confirmed immunohistochemically in breast cancer cases., findings suggest that while the first ZF does not contribute to the transcription-associated functions of Slug, all the remaining four ZFs are involved in regulating the expression of target genes with ZF3 and ZF4 being more crucial than ZF2 or ZF5, Data showed a lack of association between circulating tumor cells (CTCs) and expression of epithelial to mesenchymal transition (EMT) factors, TWIST1 and SLUG, in breast tumor suggesting that expression of EMT protein is not surrogate marker of CTCs., We found that TWIST1, SNAIL and SLUG are overexpressed in endometriosis, Loss of NDRG2 induced the expression of matrix metalloproteinase-19 (MMP-19), which regulated the expression of Slug at the transcriptional level in the epithelial-mesenchymal transition of gallbladder carcinoma cells., SOX2 Promotes the Epithelial to Mesenchymal Transition of Esophageal Squamous Cells by Modulating Slug Expression through the Activation of STAT3/HIF-alpha Signaling, highly expressed in stromal villi cells of molar disease, Our study shows an inversed preferential nuclear expression of SLUG, SOX10, and SOX9 in triple negative and non-triple negative cases., Studied the role and putative interactors of SNAI2, a slug protein which is involved in the development of cancer progression. Based upon the computational analysis, we consider HNF4A could be a putative candidate to study zinc finger protein slug., SNAI1 and SNAI2 - transcriptional master-regulators of epithelial-mesenchimal transition, As a consequence, Slug transcription is down-regulated relieving A549 cells from Slug-mediated repression of E-cadherin transcription, thereby diminishing the metastatic potential of these oncogenic Ras-expressing NSCLC cells, Sox4 was also able to promote b-catenin-mediated transcription of the Slug gene through formation of transcriptional complexes with b-catenin and p300, independent of TCF4 status, we demonstrated that rLZ-8 promoted the interaction between MDM2 and Slug, resulting in Slug degradation, 4-hydroxytamoxifen resistance in breast cancer cells is suppressed by curcumin, which targets the SLUG/Hexokinase 2 pathway,
OMIM_DISEASE Piebaldism, Waardenburg syndrome, type 2D,
SP_COMMENT disease:Defects in SNAI2 are a cause of neural tube defects (NTD)., disease:Defects in SNAI2 are the cause of Waardenburg syndrome type 2D (WS2D) [MIM:608890]. WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1., function:Transcriptional repressor. Involved in the generation and migration of neural crest cells., similarity:Belongs to the snail C2H2-type zinc-finger protein family., similarity:Contains 5 C2H2-type zinc fingers., tissue specificity:Expressed in placenta and adult heart, pancreas, liver, kidney and skeletal muscle.,