Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
The Database for Annotation, Visualization and Integrated Discovery
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DAVID Functional Annotation Table
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syndecan 2(SDC2) syndecan 2(SDC2) Related Genes Homo sapiens
CHROMOSOME 8,
CYTOBAND 8q22-q23,
ENSEMBL_GENE_ID ENSG00000169439,
GENERIF_SUMMARY Identification of integrin alpha(M)beta(2) as an adhesion receptor on human peripheral blood monocytes for Cyr61 and connective tissue growth factor, role in mediating adhesion and proliferation of colon carcinoma cells, Ezrin N-terminal domain binds to the syndecan-2 cytoplasmic domain with an estimated K(D) of 0.71 microM and without the requirement of other proteins, Mechanisms for the regulation of HSPG have been studied., Interleukin-8 binds to syndecan-2 on vascular endothelial cells., the HSPG T allele is a risk factor for the development of severe diabetic nephropathy in type 2 diabetic patients, Syndecan-2 induces osteoblastic cell apoptosis through the JNK/Bax apoptotic pathway and the cytoplasmic domain of syndecan-2 is required for this action., the transmembrane domains are sufficient for inducing dimerization and transmembrane domain-induced oligomerization is crucial for syndecan-2 and syndecan-4 functions, PKCdelta acts as a pro-survival kinase and that SYND2 inhibits the anti-apoptotic action of PKCdelta in osteoblast., molecular complex most likely to obstruct RACK1 for functional attachment at syndecan-2, as revealed in cells transfected with oncogenic ras, HSPGs are expressed on the membrane of myeloid leukemic cell lineages., heparanase-1 expression and heparan sulphate proteoglycan degradation are induced by estradiol in human endometrium, these data suggested that both HSPG and CD81 are important for HCV entry., HSPG modulation of BMP signaling in myositis ossificans cells is reported., syndecan-2 acts as a suppressor for MMP-2 activation, causing suppression of metastasis, There are pronounced tubulointerstitial HSPG alterations in primary kidney disease, which may affect the inflammatory response., syndecan TMD homodimerization and heterodimerization can be mediated by GxxxG motifs and modulated by sequence context, This study provides evidence for the up-regulation of syndecan-2 and -4 in human primary CD4 T cells during in vitro activation and suggest an inhibitory role for these syndecans in CD4 T cells., pleiotrophin (PTN) and syndecan-2 and -3 as direct binding partners of Y-P30., A pivotal role of this heparan sulphate proteoglycan in the formation of new blood vessels., HSPGs and HSPG-dependent signaling are affected in both central and peripheral chondrosarcomas., SDC2 and CYR61 expression affect the severity of cancer, and the survival of patients with esophageal squamous cell carcinoma (ESCC)., estradiol affects the expression of syndecan-2, but not of syndecan-4, through ERalpha, changes in the pattern expression of syndecan-1 and -2 indicate that both molecules may be involved in the epithelial-mesenchymal transition (EMT) and tumor progression of prostate cancer., Syndecan-2 plays a crucial role in the migratory potential of melanoma cells., Study results supported the potential role of SDC2 in prostatic carcinogenesis and cancer progression., Data report that the bFGF, FGFR1/2 and syndecan 1-4 expressions are altered in bladder tumours., these results suggest that syndecan-2 regulates cell migration of colon carcinoma cells through Tiam1-dependent Rac activation in colon cancer cells., syndecan's interactions with both CASK and neurofibromin are dependent on syndecan homodimerization., Results support a potential role for syndecan-2 in pancreatic carcinogenesis and cancer progression. Expression of syndecan-2 might serve as a prognostic marker., RGD-independent cell adhesion via a tissue transglutaminase 2-fibronectin matrix promotes fibronectin fibril deposition and requires syndecan-4/2 and {alpha}5{beta}1 integrin co-signaling., syndecan-2 and syndecan-4 regulate the compensatory effect of TG-FN on osteoblast cell adhesion and actin cytoskeletal formation in the presence of RGD peptides., These results demonstrate that syndecan-1 and syndecan-2 gene silencing by RNA interference reduces HSV-1 entry, plaque formation and facilitates cell survival., The findings demonstrate that LRP1 and HSPG function in a cooperative manner to mediate cellular Abeta uptake and define a major pathway through which Abeta gains entry to neuronal cells., syndecan-2 was expressed preferentially in basal cells in benign tissue. In prostate cancer samples, syndecan 2 was expressed in granular-cytoplasmic localisation., HIV-1 p17 matrix protein interacts with heparan sulfate side chain of CD44v3, syndecan-2, and syndecan-4 proteoglycans expressed on human activated CD4+ T cells affecting tumor necrosis factor alpha and interleukin 2 production., the cytoplasmic domain of syndecan-2 regulates colon cancer cell migration via interaction with syntenin-1., Here the protein tyrosine phosphatase receptor CD148 is shown to be a key intermediary in cell adhesion to syndecan-2 extracellular domain, with downstream beta1 integrin-mediated adhesion and cytoskeletal organization., a specific glycochain is a receptor for dengue virus strain DEN2 16681, the data suggest that MMP-7 directly mediates shedding of syndecan-2 from colon cancer cells., Syndecan 1 and syndecan 2 are cellular molecules responsible for susceptibility to HTLV-1., Notch receptors control their own activity by inducing the expression of syndecan-2, which then acts to propagate Notch signaling by direct receptor interaction., SDC-2 is a novel (perineural) invasion-associated gene in PDAC which cooperates with K-ras to induce a more invasive phenotype., MC1R regulates melanoma cell migration via inhibition of syndecan-2 expression., The repression of syndecan-2 by Wnt/beta-catenin/TCF signaling contributes to the resistance of osteosarcoma cells to doxorubicin., Report demonstrates that syndecan-1 enhances malignancy of a mesenchymal tumour cell line, via induction of syndecan-2 expression., lower TCR/CD3 surface levels caused by syndecan-2 led to reduced TCR/CD3 responsiveness, SDC-2 modulates TGFbeta2 transcriptional regulation via Smad2 signaling to facilitate fibrosarcoma cell adhesion., Taken together, these results suggest that the extracellular domain of syndecan-2 regulates the interaction of HCT116 human colon carcinoma cells with fibronectin., DNA from 4 HPV positive and 4 HPV negative fresh frozen primary HNSCC were subject to comprehensive genome-wide methylation profiling.Pathway analysis of 1168 methylated genes showed 8 signal transduction pathways (SDC2) of which 62% are hypermethylated., Clinical validation of SDC2 methylation in serum DNA by quantitative methylation-specific PCR demonstrated a high sensitivity of 87.0% (95% CI, 80.0% to 92.3%) in detecting cancers., RKIP, LOX and SDC2 are coordinately regulated and collectively encompass a prognostic signature for metastasis-free survival in ER-negative breast cancer patients, syndecan 2 shows no changes associated to histological grade of Prostate cancer, SDC2 is overexpressed in Leri's pleonosteosis. The minor allele of a missense SDC2 variant, p.Ser71Thr, could confer protection against systemic sclerosis., RhoA, but not RhoC was shown to be essential for the anchored phenotype of breast carcinoma cells that accompanied siRNA-mediated loss of syndecan-2., SDC2 expression was higher in skin melnaoma cells. It enhanced tyrosinase activity by increasing the membrane and melanosome localization of protein kinase CbetaII. UVB-induced up-regulation was required for UVB-induced melanin synthesis., Taken together, these data suggest that IL-1alpha regulates extracellular domain shedding of syndecan-2 through regulation of the MAP kinase-mediated MMP-7 expression in colon cancer cells., The results demonstrate the importance of PDZ-binding domain of syndecan-2 for controlling LFA-1 affinity and cell adhesion., HIV matrix protein p17 is pro-fibrogenic through its interactions both with CXCR2 and syndecan-2 on activated HSCs, Extracellular matrix proteins expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line., Data indicate that the extracellular and cytoplasmic domains of syndecans 1/2/3/4 are intrinsically disordered regions., In this review we considered the function of syndecan-2, the structure of syndecan-2 and its role in the formation of amyloid plaques.,
SP_COMMENT function:Cell surface proteoglycan that bears heparan sulfate., function:Cell surface proteoglycan., similarity:Belongs to the syndecan proteoglycan family.,