Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
The Database for Annotation, Visualization and Integrated Discovery
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DAVID Functional Annotation Table
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integrin subunit alpha V(ITGAV) integrin subunit alpha V(ITGAV) Related Genes Homo sapiens
CHROMOSOME 2,
CYTOBAND 2q31-q32,
ENSEMBL_GENE_ID ENSG00000138448,
GENERIF_SUMMARY integrin alphavbeta3 is shown to interact with PECAM-1, Processing of integrin alpha(v) subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin, Acute hyperglycaemia induces an up-regulation of seven major genes, four of which were not previously reported in the literature. Northern blot analyses, performed on these 4 genes, confirm macroarrays results for alphav, beta4, c-myc, and MUC18., Review. Alpha(v)beta3 integrins are involved in vascular repair processes. The challenge is to develop a therapeutic agent that will prove effective in reducing restenosis in humans following percutaneous coronary intervention (PCI)., They analyzed the expression of these cell surface receptors in nine ovarian cancer cell lines and also in the primary human ovarian surface epithelial cell line (HOSE)., Chemotaxis and chemoinvasion analyses revealed a dose-dependent increase in prostate cancer cell movement induced by osteopontin and a strict dependence of cell invasion on alphavbeta3 integrin function., Unique ability of integrin alpha(v)beta 3 to support tumor cell arrest under dynamic flow conditions (Integrin alpha-v beta-3), Del1 mediates vascular smooth muscle cell adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3)., Factor XIII mediates adhesion of platelets to endothelial cells through alpha(v)beta(3) and glycoprotein IIb/IIIa integrins., Acute cellular rejection following human heart transplantation is associated with increased expression, existence of an alpha V integrin/vitronectin connection in hepatocellular carcinoma and suggest that this connection may be an adverse prognostic factor., Alpha(v)beta(3) integrin engagement enhances cell invasiveness in human multiple myeloma., integrin alphaVbeta3 expression is reduced when ROR alpha is activated in prostate cancer cells, Integrin alphavbeta3. Expression of integrin alpha v beta 3 promotes the metastatic phenotype in human melanoma by supporting specific adhesive, invasive and migratory properties of the tumor cells, alpha v beta 3 integrin signaling through Shc recruitment in response to mechanical stimulation in human osteoblasts, phosphoinositide 3-kinase C2alpha was found to be differentially regulated by alpha(v)beta(3) engagement, promotion of integrin alpha Vbeta 3-dependent endothelial cell adhesion by PGE2, identification of a new alphavbeta5 integrin-interacting motif that is highly conserved in the fas-1 domains of many proteins suggesting that fas-1 domain-containing proteins may perform their biological functions by interacting with integrins, induced alpha(v)beta(8) integrin expression mediated Fas-stimulated migration, identification of functional segments within the beta2I-domain, Data show clearly that integrin alpha(v)beta(3) interacts with the latency-associated peptide (LAPbeta1 and 3) RGD motif., role in mediating pro-angiogenic activity of CYR61, An autocrine loop of the integrin alpha(V)beta(3)/CD47 receptor complex and thrombospondin-1 is identified as the molecular coupling device between mechanical loading and apoptosis., in patients with endometriosis a significant negative correlation was observed between luminal expression of eNOS and alpha(v)beta(3) integrin and between glandular expression of eNOS and luminal expression of alpha(v)beta(3) integrin, thrombin interacts with alphavbeta3 as demonstrated by direct binding of alphavbeta3 protein to immobilized thrombin., Overexpression of integrin alphaV promotes human osteosarcoma cell populated collagen lattice contraction and cell movement., activation state of alphaVbeta3 integrin is an important regulator of the duration of insulin-like growth factor I receptor phosphorylation and this regulation is mediated through changes in the subcellular localization of SHP-2, Data show a novel mechanism by which ECM regulates membrane-type 1 matrix metalloproteinase (MT1-MMP) association with beta1 or alphavbeta3 integrins, thus modulating its internalization, activity, and function on human endothelial cells., integrin alpha5beta1-mediated control of the levels of integrin alphaVbeta3 is important for the distribution of focal contacts, has a role in the early phase of liver metastasis, thymidine phosphorylase and 2-deoxyribose-induced focal adhesion kinase phosphorylation was blocked by the antibodies to integrins alpha 5 beta 1 and alpha v beta 3, directly linking their migration and signaling components, role in regulating cell proliferation through integrin-linked kinase (ILK) in ovarian cancer cells, decreased expression of endometrial integrin alphavbeta3 suggests that functional, but not morphological, endometrial defect may be one of the causes for the patients with unexplained infertility and recurrent IVF-ET failures, Alphavbeta3 integrin expression and pinopode formation in human endometrium are processes closely related to endometrial maturation; unlikely as targets for contraceptive approaches or fertility-promoting strategies, tumstatin binds to alpha v beta 3 integrin in a vitronectin/fibronectin/RGD cyclic peptide independent manner, Data suggest that this alphavbeta3 binding to alpha5-laminins is involved in the regulation of cellular responses to growth factors known to be involved in epithelial and endothelial development., signaling through JAM-1 and alphavbeta3 is necessary for bFGF-induced angiogenesis., Data provide the first evidence that alphavbeta3 integrin can generate apoptosis-stimulating signals., alpha 5 beta 1 and alpha v beta 3 are both important but cell-specific fibrillin-1 receptors, integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells, These data provide evidence for a functional role for integrin alphavbeta8-mediated activation of transforming growth factor-beta in control of human airway epithelial proliferation in vivo., AlphaV- and beta1-integrin subunits are commonly expressed in malignant effusions from ovarian carcinoma patients., integrin alpha(v)beta3 has an important role in bone metabolism and angiogenesis, and in controlling growth of metastatic prostate cancer cells in the bone, Disulfide bonding patterns of the integrin alpha V chain are described; the alpha chain displays differences in the disulfide patterns of those bonds near their C-terminal regions linking the heavy and light chains., alpha3beta1, alpha4beta1 and alphaVbeta1 integrins may play an important role in the implantation process, alphav subunit cleavage is essential for integrin function and has a considerable impact on integrin-dependent events, especially those leading to cell migration, alpha(v)beta(1) supports fetal beta-cell migration and could play an important role in early motile processes required for islet neogenesis, CD47-alpha(v)beta(3) interactions that lead to integrin clustering are detergent resistant and do not require cholesterol or the transmembrane region of CD47, alphavbeta3 integrin has a role in regulating proliferation and apoptosis of hepatic stellate cells, Role of alpha4, alpha5, and alphav integrin receptors--which are central to mediating interactions with these domains of FN--in regulating ssquamous cell carcinoma migration., integrin alpha(v)beta(6) is an RGD-dependent receptor for Coxsackievirus A9 and may be important in natural Coxsackievirus A9 infections, alpha-v integrin signals through JAB1 (Jun activation binding protein 1) to prolong MMP1 production, secondary structure analysis of integrin alphaVbeta3, CEACAM1 and alpha(v)beta(3) integrin are functionally interconnected with respect to the invasive growth of melanomas, Integrin alphav controls melanoma cell survival in 3D-collagen through a pathway involving p53 regulation of MEK1 signaling., alphav integrins and MMP2 have roles in migration of human ovarian adenocarcinoma cells through endothelial extracellular matrix, The Integrin alphaV receptor is members of the group of the cellular adhesion molecules (CAM), are heterodimeric transmembrane glycoprotein receptors involved in processes such as cell-cell and cell-matrix adhesion, cell migration and signaling., BMP-2 upregulates the expression of alphavbeta integrins, and these integrins, in turn, play a critical role in BMP-2 function in osteoblasts, Pyk2 is a phosphorylated beta(3) binding partner, providing a potential structural and signaling platform to achieve alpha(V)beta(3) -mediated remodeling of the actin cytoskele, We conclude that the ectodomain of alphaVbeta3 manifests a bent conformation that is capable of stably binding a physiological ligand in solution., We conclude that integrin alphavbeta6-dependent MMP-2 and -9 up-regulation is an important feature of increased migration in hypoxic human keratinocytes., Epidermal growth factor receptor and alphavbeta3 work together as coreceptors for Human cytomegalovirus entry and signaling., urokinase receptor-derived SRSRY peptide regulates cross-talk between fMLP and vitronectin receptors, new pair of adhesion molecules, Thy-1 and alphavbeta3, inditified that mediate the interaction of melanoma cells and activated endothelial cells, IGROV1 cells were shown to adhere rapidly on the HUVECs monolayer; adhesion was inhibited by anti-alphav integrin and anti-Vn blocking antibodies, but not by anti-beta1 integrin antibodies, Gal3ST-2 is involved in tumor metastasis process by regulation of adhesion ability to selectins and expression of integrin alphaV but not beta3, May contribute to the formation of arteriovenous malformaions in younger patients., melanoma cells cross-present, in an alpha v beta3-dependent manner, an antigen derived from secreted matrix metalloproteinase-2 (MMP-2) to human leukocyte antigen A*0201-restricted T cells, integrin alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 binding to osteopontin is controlled by specific structural motifs that are recognized by extracellular proteases, Alphavbeta6 integrin down-regulates MMP-13 expression in oral squamous cell carcinoma cells., Increased transcripts of activators of TGFB1 (Itgav and Thbs1), and genes that are activated by TGFB1 (Spp1, Timp1, and Tnc) occurs during acute lung injury, Data show that alpha(v)beta3/Tat interaction triggers the activation of NF-kappaB in endothelial cells in a focal adhesion kinase-, RhoA- and pp60src-dependent manner, and this activation is required for motogenic activity of Tat in endothelial cells., alphavbeta3 integrin is transiently up-regulated (and activated) in graft arteriopathy, the RGD-dependent interaction between the P2Y(2)R and alpha(v) integrins is necessary for the P2Y(2)R to activate G(o) and to initiate G(o)-mediated signaling events leading to chemotaxis, Expression of integrins alphavbeta1, alphavbeta3, and alphavbeta5 in cerebral arteriovenous malformations and cavernous malformations. (Integrins alphavbeta1, alphavbeta3, and alphavbeta5), the signal interaction between IGF-1R and alpha(v)beta3 integrin plays an important role in promoting the development and progression of cervical cancer, cardiotoxin A5 binds to alpha(v)beta3 integrin and inhibits bone resorption, These results indicate that the alpha2beta1 and alphaVbeta1 integrin signaling pathway may be critical components of neurodegeneration in Alzheimer's disease., thymosin beta10, but not thymosin beta4, have direct inhibitive effects on endothelial migration and tube formation that might be mediated via downregulation of VEGF, VEGFR-1 and integrin alphaV in HCAECs., While tolerogenic DCs are not induced via alphavbeta5, coligation of CR3 and alphavbeta5 maintains the DC's tolerogenic profile., Findings suggest that in melanoma cells the increase in MMP-2 activity, CD44 surface expression, and cell migration is integrin alpha V-dependent., The effects of the EBV nuclear antigen 3C on the activities of Nm23-H1 via GATA-1 and Sp1 are reported., Alphavbeta5 integrin may play a role in the adhesion and migration of VSMCs during the pathogenesis of atherosclerosis., upregulated expression of alphavbeta5 contributes to autocrine TGF-beta signaling in localized scleroderma fibroblasts, periostin has an active role in the epithelial-mesenchymal transformation and metastasis that requires cross-talk between integrin and EGFR signaling pathways, integrin alpha3beta1 is a receptor for the alpha3NC1 domain and transdominantly inhibits integrin alphavbeta3 activation, binding of resveratrol to integrin alphaVbeta3, principally to the beta3 monomer, is essential for transduction of the stilbene signal into p53-dependent apoptosis of breast cancer cells., PET Molecular imaging of alpha(v)beta3 expression with [18F]Galacto-RGD in humans correlates with alpha(v)beta3 expression as determined by immunohistochemistry., S 36578-2 is highly selective for alpha v beta3 and alpha v beta5 integrins and induces detachment, caspase-8 activation, and apoptosis in human umbilical endothelial cells, These findings elucidate the function and complex regulation of integrin-mediated activation of TGF-beta within the epithelial-mesenchymal trophic unit (EMTU).[integrin alphavbt=eta6, integrin alphavbeta8], Relevance of betaIG-H3 and alpha v beta3 integrin-interacting motifs as potential therapeutic targets in rheumatoid arthritis., integrin binding loop of Foot-and-mouth disease virus has most likely evolved for binding to alphavbeta6 with a higher affinity than to alphavbeta3 and alphavbeta8, The transition from a locally invasive phenotype to a metastatic phenotype may be primed by the elevated expression of alpha(v)beta(3) receptors in prostate cancer cells., identifies integrin alphaVbeta6 as a novel cellular receptor for fibrillin-1 with a K(d) of approximately 0.45 mum, type I collagen induction of MT1-MMP-mediated MMP-2 activation is repressed by alphaVbeta3 integrin in human breast cancer cells, Mn(2+) promoted convergent changes in integrin alphavbeta6 conformation and Fb structure through activation of ERK/MAPK and MMP-9, integrins alpha5beta1 and alphaV are inhibited by lebectin and lebecetin snake venom lectins, Adhesion of breast cancer cells through the VLA integrins alpha2beta1 and alpha5beta1 was significantly reduced by an apoptosis-inducing natural triterpenoid, dehydrothyrsiferol (DT), when studied on low amounts of extracellular matrix., Prostate cancer cells expressing fully functional but not dysregulated alphavbeta3 integrin are able to control their own adherence and migration to bone matrix, functions that facilitate tumor growth and control bone lesion development., Necl-5 has a critical role in integrin alphavbeta3 clustering and focal complex formation, Endothelial cell integrin alphaV beta3 is involved in sickle cell red blood cell adhesion., Results suggest that CTGF plays a crucial role in migratory/invasive processes in human breast cancer by a mechanism involving activation of the integrin-alphavbeta3-ERK1/2-S100A4 pathway., The rs3738919-C allele of the ITGAV gene is associated with rheumatoid arthritis in the European Caucasian population, suggesting ITGAV as a new minor susceptibility gene for rheumatoid arthritis., establishes alphavbeta3 integrin as one key component of the transendothelial migration process of tumor cells, and as a potential target for anti-metastatic therapy, c-Src controls functional association between integrin alphav-beta3 and VEGFR-2 via integrin beta3 phosphorylation., macrophage migration inhibitory factor directly up-regulates alphavbeta3 integrin and VEGF expression in human endometrial Ishikawa cells, These findings provide evidence that mutations in fibronectin, induce anoikis in human squamous cell carcinoma cells by modulating integrin alpha v-mediated phosphorylation of FAK and ERK., Results show that the tyrosine phosphatase protein-tyrosine phosphatase mu dephosphorylated PIPKIgamma and thus canceled the PIPKIgamma-dependent activation of integrin alpha(v)beta(3) by blocking the interaction of integrin alpha(v)beta(3) with talin., the studies demonstrate that Vbeta3 is a cellular receptor mediating both the cell adhesion and entry of KSHV into target cells through binding the virion-associated gB(RGD)., Report observed that alphav-beta3 integrins and Focal Adhesion Protein-Tyrosine Kinases co-localize and that fibrillin filament attachment sites to endothelial cells merge with these molecules., anti-tumor and anti-metastatic activities of CNTO 95 in breast cancer models and provide insight into the cellular and molecular mechanisms mediating its inhibitory effects on metastasis., Signal transduction pathways underlying the enhanced cell migration reveal that the IGF-I-IGFBP-VN complex stimulates a transient activation of the ERK/MAPK signaling pathway and a sustained activation of the phosphatidylinositide 3-kinase/AKT pathway., uPAR is required to activate alphavbeta3 integrin in podocytes, promoting cell motility and activation of the small GTPases Cdc42 and Rac1, Alpha v beta 5, alpha v beta 5 and their ligands Del-1 and L1 play an important role in the process of tumor cells moving from the original place., TGF-beta1 acts through PI3K/Akt, which in turn activates IKKalpha/beta and NF-kappaB, resulting in the activations of alphavbeta3 integrins and contributing the migration of chondrosarcoma cells, We used suppression subtractive hybridization (SSH) to study molecular signature of melanoma progression, by showing characteristics of early neoplastic lesions including expression of KISS1, lack of alphavbeta3-integrin and low levels of RHOC., Integrin alphavbeta6 is induced de novo in rodent and human liver fibrosis, where it is expressed on activated bile duct epithelia and (transitional) hepatocytes during fibrosis progression., The role of alpha(v)beta(3) and Fas as the mediators of streptococcal pyrogenic exotoxin (SPE) B-induced apoptosis is described., Integrin alpha v beta 3 plays a critical role in the S1P-stimulated chemotactic response of ECs, The shear-induced G(2)/M arrest and corresponding changes in G(2)/M regulatory protein expression and activity were mediated by alpha(v)beta(3) and beta(1) integrins through bone morphogenetic protein receptor type IA-specific Smad1 and Smad5., T(3) and T(4) hormones rapidly stimulate ERK activation in MG-63 cells via integrin alpha(V)beta(3) and that one functional effect of this ERK activation is increased DNA synthesis, Mn(2+) simultaneously modulates the thiol isomerase activity of protein disulfide isomerase that is bound to alpha(V)beta(3) and induces its transition to the ligand-competent state, suggesting an alternative mechanism of integrin regulation, Data show that in preeclamptic pregnancies, histamine does not stimulate expression of integrin alphaVbeta3, as it does in uncomplicated pergnancies., These results suggest that activation of TGF-beta1 by integrin alphavbeta6 contributes to pathological changes and may impair endothelial cell functions in tissues that are chronically infected with cytomegalovirus., Infertile women with isolated polycystic ovaries are deficient in endometrial expression of osteopontin but not alphavbeta3 integrin during the implantation window., results demonstrate that TGFbeta1 induces alphavbeta3 integrin expression via a beta3 integrin-, c-Src-, and p38 MAPK-dependent pathway, There was significant relationship between integrin alpha-v subunit expression and lymphatic metastasis of laryngeal and hypopharyngeal squamous cell carcinoma., ROCK-dependent actomyosin-driven contractility is a critical determinant for the regulation of the interaction between Necl-5 and integrin alpha(V)beta(3)., significant difference in the expression of the beta(3) integrin subunit between primary glioblastomas compared with low-grade gliomas, expression of ITGAV was significantly correlated with differentiation and metastasis of the laryngeal and hypopharyngeal carcinomas; down-regulation of ITGAV gene could inhibit proliferation of Hep-2 cells and induce to its apoptosis., integrin alphavbeta3 binding to FGF1 plays a role in FGF1 signaling, data identify PAI1 as a novel regulator of fibronectin matrix assembly, and indicate that this regulation occurs through a previously undescribed crosstalk between the alphavbeta5 and alpha5beta1 integrins, Alpha vbeta 6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation., osteopontin, integrins alphavbeta3 and alpha4beta1 may serve as receptors for sPLA2-IIA and mediate pro-inflammatory action of sPLA2-IIA, human umbilical vein endothelial cells adhere to immobilized CXCL4 through alphavbeta3 integrin, and also through other integrins, such as alphavbeta5 and alpha5beta1, Integrin alphavbeta3 is not significantly implicated in the anti-migratory effect of anti-angiogenic urokinase kringle domain, overexpressed in endometrial carcinomas, especially with high grade and in lymph node metastases, ability of ovarian carcinoma cells to bind to peritoneal mesothelium in vitro and strongly suggest that vitronectin and its receptors contribute to this crucial event., SDF-1alpha enhances the invasiveness of chondrosarcoma cells by increasing alphavbeta3 integrin expression through the CXCR4/ERK/NF-kappaB signal transduction pathway., The apo(a) component of Lp(a) signals through integrin alphaVbeta3 to activate endothelial cells., urokinase-derived antagonists of alphavbeta5 integrin activation inhibit migration and invasion of carcinoma cells, These results demonstrate that integrin alphavbeta3-mediated transcriptional regulation of MMP-9 and TIMP-1 is critical for suppressing the ovarian cancer cell invasion., VWF strings bind specifically to integrin alpha(v)beta(3) on human endothelial cells, Analogous to EAE, in subjects with MS, we found increased expression of Opn in DCs and increased expression of the Opn receptors CD44, beta(3), and alpha(v) on T cells., M6P/IGF2R controls cell invasion by regulating alphaV integrin expression and by accelerating uPAR cleavage, leading to the loss of the urokinase/vitronectin/integrin-binding site on uPAR., in cutaneous nodular melanomas, necrosis was associated with increased tumor thickness, tumor ulceration, vascular invasion, higher tumor proliferation and apoptotic index, increased expression of alphavbeta3 integrin & poor patient outcome, analysis of how the different antiangiogenic potential of resveratrol stereoisomers is related to their different capacity to affect alphavbeta3 integrin function, These data suggest that Coxsackievirus A9 binding to alphaVbeta6 is a high-affinity interaction, which may indicate its importance in clinical infections, pneumococci exploit the vitronectin-alphavbeta3-integrin complex as a cellular receptor for invasion and this integrin-mediated internalization requires the cooperation between the host signalling molecules ILK, PI3K and Akt., data suggest that alpha(v)beta(3) is a key molecule that determines the stimulatory or inhibitory effect of pleiotrophin on cell migration, data suggest that alphavbeta1 integrin is a functional receptor for hMPV, Data show that cilengitide activated cell surface alphaVbeta3, stimulated phosphorylation of FAK, Src and VE-cadherin, increased cell permeability and decreased cell adhesion in endothelial cells., In neuroendocrine tumors, gene-expression integrin alphaV was highly variable, The active site within the Sdc1 core protein was identified and a peptide inhibitor called synstatin (SSTN) that disrupts Sdc1's interaction with alpha(v)beta(3) and alpha(v)beta(5) integrins was derived., Compound 4, having the DGR retro-sequence, is a low micromolar ligand for the alphavbeta5 integrin., Data demonstrated significantly upregulated integrin-linked kinase as a function of alphavbeta3 in two ovarian cancer cell lines, and proved co-localization at the surface of alphavbeta3-overexpressing adherent cells., These data strongly indicate that KAI1 may suppress ovarian cancer progression by inhibiting integrin alphavbeta3/vitronectin-provoked tumor cell motility and proliferation as important hallmarks of the oncogenic process., Down-regulation of alphav integrin by retroviral delivery of siRNA significantly reduced drug resistance of colon tumor cells & xenografts, indicating that ITGAV plays an important role in MCR to oxaliplatin in colon cancer cells., Results show that alphavbeta6- and alpha5beta1-integrin-dependent activation of Rac1 was mediated through Eps8., OPN enhances the migration of chondrosarcoma cells by increasing MMP-9 expression through the alphavbeta3 integrin, FAK, MEK, ERK and NF-kappaB signal transduction pathway., PAI-1-mediated regulation of alphavbeta3 integrin is critical for the control of TGFbeta signaling and the prevention of fibrotic disease., In metastatic brain lesions carrying activated alpha(v)beta(3), VEGF expression is controlled at the post-transcriptional level and involves phosphorylation and inhibition of translational respressor 4E-binding protein (4E-BP1)., Tumors express alpha(v)beta(6) suggest that this probe has significant potential for the in vivo detection of the malignancy., VEGF is critical to the invasive process in human gastric cancer and that this occurs via up-regulation of integrin alphavbeta6 expression and activation of ERK., Cell adhesion to tropoelastin is mediated via the C-terminal GRKRK motif and integrin alphaVbeta3, Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway, These data are the first demonstration of conformational coupling of the integrin alphaVbeta3 leg and head domains, and suggest that inside-out activation may involve conformational changes other than the postulated switch to a genu-linear state., upregulated expression in lung adenocarcinoma cells following bacterial infection, Smooth muscle cell hyperplasia in stricturing Crohn disease is regulated by increased endogenous IGF-I and alphaVbeta3 integrin ligands that regulate augmented proliferation and diminished apoptosis, Data show that leberagin-C can inhibit the adhesion of melanoma tumour cells on fibrinogen and fibronectin, by interfering with the function of alphavbeta3 and, to a lesser extent, with alphavbeta6 and alpha5beta1 integrins., This study shows that alpha(v)beta(3)-integrin expression on tumor cells actually slows tumor progression and acts as a tumor suppressor., Beta1 integrins are required for adhesion and proliferation of induced pluripotent stem cells on matrigel. On vitronectin, the integrin alphavbeta5 is required for initial attachment, but both alphavbeta5 and beta1 is required for proliferation., Data show that under basal conditions, sphingosine kinase-1, integrin alpha(v)beta(3), and CD31 exist as a heterotrimeric complex which is required in SK-1-mediated endothelial cell survival., Association of ITGAV SNP rs7378919 with rhuematoid arthritis was not replicated in New Zealand or Oxford case control sample sets, alphav beta3 integrin may, in part, negatively regulate VEGF signaling by sequestering NRP1 and preventing it from interacting with VEGFR2, suggest that a divalent metal-ion coordination was a common driving force for the formation of both SDV/alpha v beta 3 and RGD/alpha v beta 3 complexes., GPIIb/IIIa and alphavbeta3 integrins are important mediators in the pathology of cervical cancer., VEGFR-2 was significantly upregulated by alpha-v suppression in HUVEC & downregulated in HMVEC at mRNA & protein levels. Suppression of alpha-v can either augment or inhibit VEGFR-2 levels & VEGF-induced proliferation in EC from different vascular beds., Oscillatory shear stress induces osteoblast-like cell proliferation through activation of alpha(v)beta(3) and beta(1) integrins and synergistic interactions of FAK and Shc with PI3K, leading to the modulation of ERK and Akt/mTOR/p70S6K pathways., The angiogenic effects of leptin are mediated by circulating angiogenic cells and involve src kinase dependent phosphorylation of integrin alphavbeta5., Blocking integrin alpha V beta 3 inhibits differentiation and subsequently tumor formation., Reduced expression of integrin beta8 may be involved in the pathogenesis of sporadic brain arteriovenous malformations., Definitive endoderm highly express the integrins alphaV and beta5, which have the ability to bind to vitronectin., Data show that cartilage oligomeric matrix protein (COMP) promotes cell attachment via independent mechanisms involving cell surface CD47 and alphaVbeta3 integrin and that cell attachment to COMP induces formation of fascin-stabilized actin microspikes., OPN and its receptor integrin alphanubeta3 may be involved in the pathogenesis of preeclampsia., Mast cell-bronchial smooth muscle cell adhesion involved collagen, CD44, and CD51, particularly under inflammatory conditions., Data show that PLT adhesion to HIMEC was ICAM-1, FKN and integrin alpha(v)beta(3) dependent., Expression of integrin alphaVbeta3 on T lymphocytes does not predict its endometrial expression., Results proved the importance of VEGF and integrin alphavbeta3 in the pathogenesis of AML., Ovarian cancer ascites induces FAK and Akt activation in an alphavbeta5 integrin-dependent pathway, which confers protection from TRAIL-induced cell death and caspase activation., These results suggest that PKD1-regulated alphavbeta3 trafficking contributes to the angiogenesis process by integrating VEGF-A signaling with extracellular matrix interactions., the Tie2/alphavbeta3 integrin association-induced integrin internalization and degradation are mechanistic consequences of endothelial Ang-2 stimulation, Alpha(V)beta(6), but not alpha(V)beta(3), blocked human parechovirus 1 cellular infectivity., Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91/LRP-1 and NF-kappaB-mediated integrin alphaV expression., A fragment of vitronectin containing the RGD integrin binding site showed similar binding affinity as that of full vitronectin protein to purified integrin alphavbeta3 but had diminished cell adhesion and spreading function in vivo., Integrin alphavbeta3 and Lewis Y, which is contained within it, are expressed in secretory-stage endometrial tissue., Integrin alphavbeta5 is a primary receptor for adenovirus., Data show that knockdown of integrin alphav and erbB3 by small-interfering RNAs significantly inhibited cell migration induced by HRG., immunohistochemistry of the endometrium indicates that the use of osteopontin and alphavbeta3 integrin as targets for contraceptive approaches or understanding of the pathogenesis of infertility offer little benefit compared with histological dating, demonstrate that alphaVbeta3 ligation results in sustained increases of PI3 kinase/Akt-dependent binding of transcription factor NF-kappaB to DNA., Periostin could be a biochemical marker of the early stromal response associated to breast cancer bone metastasis formation., PAK4 is activated by cell attachment to vitronectin as mediated by PAK4 binding partner integrin alphavbeta5., Preincubation of macrophages with HMGB1 decreased their ability to engulf apoptotic neutrophils or thymocytes. Soluble alphavbeta3 integrin, but not soluble alphavbeta5 integrin, prevented this inhibition., These results demonstrate that HMGB1 blocks alpha(v)beta(3)-dependent recognition and uptake of apoptotic cells., Data showed that EhPCP5 RGD motif is a ligand for alpha(V)beta(3) integrin-mediated adhesion on colonic cells and represents a novel mechanism to trigger an inflammatory response in the pathogenesis of intestinal amebiasis., Saturation transfer difference NMR was applied to the interaction of the integrin alphavbeta6 with a known peptide ligand and highlights novel contact points between the substrate and target protein, TNF-alpha enhances the migration of chondrosarcoma cells by increasing alphavbeta3 integrin expression through the MEK/ERK/NF-kappaB signal transduction pathway., The mRNA levels of IntegrinalphaV and Integrinbeta8 were significantly higher in LSCC tissues than that in corresponding adjacent normal tissues., Leptin stimulates the migration of human prostate cancer cells via transcriptional up-regulation of alphavbeta3 integrin expression., Results show that uPAR expression regulates the adhesive and migratory ability of CXCR4-expressing cells through a mechanism involving fMLP receptors and alpha-v integrins., TF-PAR-1 pathway contributes to liver fibrosis induced by chronic cholestasis by increasing expression of the alphaVbeta6 integrin, an important regulator of transforming growth factor-beta1 activation., beta5 integrin is identified as the most important partner of the alpha vitronectin-coupled integrin dimer in monocyte-derived macrophages, thus rendering these cells more susceptible to NF-kappaB-dependent HIV-1 infection., ITGAV is a genetic determinant for the severe progression of primary biliary cirrhosis in Japanese patients, When polymorphonuclear leukocytes are recruited to tumor cells in a tumor microenvironment, alphaVbeta3 and intercellular adhesion molecule (ICAM)-1 may participate in multistep fibrin(ogen)-mediated melanoma cell adhesion within the circulation., Integrin alphav is the main CAM subunit of uterine leiomyomas that involve angiogenesis, The authors demonstrated that both integrins alphavbeta6 and alphavbeta8 can serve as specific receptors for Epstein-Barr virus gHgL proteins., ITGAV is present in all cortical layers, the striatum and Purkinje cells. It is known to be involved in cortical development, the role of acidic extracellular pH in regulating activation of integrin alpha(v)beta(3)., PET of alphavbeta3-integrin and alphavbeta5-integrin expression with 18F-fluciclatide for assessment of response to targeted therapy., data demonstrated that (18)F-fluciclatide detected changes in tumor uptake after acute antiangiogenic therapy markedly earlier than any significant volumetric changes were observable., CCN3 enhances the migration of chondrosarcoma cells by increasing MMP-13 expression through the alphavbeta3/alphavbeta5 integrin receptor, FAK, PI3K, Akt, p65, and NF-kappaB signal transduction pathway., chemokine receptor 7 regulates cell adhesion and migration via integrin alpha v beta 3 in metastatic squamous cell carcinoma of the head and neck, S100A4 protects gastric cancer cells from anoikis by regulation of alphav and alpha5 integrin expression, which sheds a novel light for the role of S100A4 in cancer metastasis, Alpha v integrin was expressed at robust levels in tumor cells representing less differentiated, more invasive components of squamous cell carcinomas, Performed molecular dynamics to simulate forced unbending of a complete integrin alpha(v)beta ectodomain in both unliganded and liganded forms., Our findings indicate that alphavbeta5 integrin may be involved in the change that occurs in monolayer-cultured chondrocytes after plating, Direct contact between tumor cells and human epithelial-like stem cells treated with DMBA increased integrin alpha V expression and caused local activation of the transforming growth factor (TGF)-beta1/Smad signaling pathways., Integrin alphavbeta3 promotes vitronectin gene expression in human ovarian cancer cells by implicating rel transcription factors, With increased tension cytoskeletal stress fibers develop that contain alphaSMA and alphavbeta3 integrin that replaces alpha2beta1 integrin, consistent with cell switching from collagen to non-collagen proteins interactions., IL-8 increases integrin alpha V expression and cell motility in human chondrosarcoma cells, Data suggest that lung fibroblast chemokine secretion directs dendritic cell trafficking, in a manner that is critically dependent on alphavbeta8-mediated activation of TGF-beta by fibroblasts., Data showt targeting of alpha(v)-integrin by GLPG0187 can inhibit both de novo formation as well as progression of bone metastases in prostate cancer., The mechanism of decreased cell migration, a prerequisite for metastasis and invasion, due to increased CAR expression may be explained by reduced alphavbeta3 integrin expression., Integrin alpha(nu) beta(3), NTRS1 and PSCA mRNA expression increased with tumorigenic potential, but mRNA expression levels for these proteins do not translate directly to equivalent expression levels of membrane bound protein., Integrin subunits alpha5 and alpha6 regulate cell cycle by modulating the chk1 and Rb/E2F pathways to affect breast cancer metastasis., analysis of alpha(nu)beta(3) integrin expression by (64)Cu- and (68)Ga-labeled RGD conjugates, The alphav integrins are an important group of adhesion molecules involved in the migration and invasion of tumour cells., Overexpression of integrin alphav in laryngeal and hypopharyngeal carcinomas associated with differentiation and metastasis, The authors report that integrin alphavbeta5 can also bind to Epstein-Barr virus gHgL and trigger fusion., alphanubeta3 and alphanubeta5 have roles in photon-induced hypermigration of malignant glioma cells, an important role of PTTG in regulation of integrins alpha(V) and beta(3) and adhesion-complex proteins leading to induction of EMT, Chromosomal regions of homozygous loss, encompassing the ITGAV and RUNX1 gene, were detected in multiple samples indicating a potential role in the carcinogenesis of esophageal adenocarcinoma., Integrin-alphavbeta3 was upregulated on various therapy-resistant tumor cells through chronic activation of ATM/Chk2-and NFkappaB-mediated pathways, Data show that alphav integrin is a new gastrin target in pancreatic cancer models and contributes to gastrin effects on cell adhesion., Thyroid hormone is shown to induce human lung cancer cell proliferation via crosstalk between integrin alphavbeta3 and ERalpha., MIF enhanced the migration of chondrosarcoma cells by increasing alphavbeta3 integrin expression through the PI3K/Akt/NF-kappaB signal transduction pathway., Disulfide bonds in EGF domains of beta3 affect structure and function of alphaIIbbeta3 and alphavbeta3 integrins in different manner., Dido1 induces the expression of Integrin alphaV, thereby promoting the attachment, migration, invasion and apoptosis resistance of melanoma cells., Further characterized the intermolecular interactions between alphavbeta3 integrin and hormone analogues. Data reveal T(3) and T(4)ac bind in two different modes, occupying two alternate binding sites on alphavbeta3 integrin., knockdown of endogenous alphavbeta5 expression or treatment with a function-blocking alphavbeta5 antibody significantly decreased stabilin-2-mediated phagocytosis in the absence of soluble factors, Active MMP-2 regulates VEGF-A in melanoma cells on a transcriptional level via an integrin alphavbeta5/phosphoinositide-3-kinase-dependent pathway., Collectively, our results indicate that FAS1 domain protein, in addition to its inhibitory effect on alpha5-beta-3 integrin-mediated angiogenesis, also inhibits VEGF165-induced angiogenesis, In vivo, we found that irradiation combined with alphaV integrin blocking treatment significantly enhanced the radiosensitivity of NPC xenografts, alpha5 endothelial cell-transgenic knockout mice display an attenuated angiogenic response which correlates with delayed endothelial proliferation; primary alpha5KO brain endothelial cells in culture exhibit delayed growth and proliferation., our findings indicate that alphavbeta6 and TGF-beta act in a common tumor suppressor pathway, Epstein-Barr virus latent membrane protein-2A induces ITAM/Syk- and Akt-dependent epithelial migration through alphav-integrin membrane translocation, These studies implicate ASM as a mediator of apoptosis induced by inhibition of integrins alphavbeta3/alphavbeta5, and for the first time place c-Abl as an upstream regulator of ASM expression and activity., CD44 signaling regulates phosphorylation of RUNX2. Localization of RUNX2 in the nucleus requires phosphorylation of Smad-5 by integrin alphavbeta3 signaling., The Protein kinase D (PKD) mediates signals from the platelet-derived growth factor receptor (PDGF-R) to control alphavbeta3 integrin recycling., thioridazine regulates endothelial cell functions that are relevant to angiogenesis through the suppression of the alphavbeta3/FAK/mTOR signaling pathway, Saccharomyces boulardii supernatant contains motogenic factors that enhance cell restitution through multiple pathways, including the dynamic fine regulation of alphavbeta5 integrin binding activity., The results demonstrate a non-redundant role for alpha(v)beta(3) in gremlin-induced angiogenesis., observations suggest that the lack of simultaneous binding of metal ions to all three betaI domain sites in alphaVbeta3 is most simply explained as an artifact of crystallization conditions, Overexpression of osteopontin, alphavbeta3 and Pim-1 associated with prognostically important clinicopathologic variables in non-small cell lung cancer., Consistent with prediction, docking simulation studies of fractalkine's chemokine domain show direct interaction with integrins alphavbeta3 and alpha4beta1 at very high affinity., overexpression of the ITGAV gene and protein was correlated with an increased risk of perineural invasion in colorectal cancer., propose that alphavbeta3-integrin is considered a class of non-TLR pattern recognition receptors., alphavbeta3 integrin and nucleolin interact to regulate endothelial and glioma cell migration, RGD peptide plays an important role in the modulation of cell motility and in the perturbation of cell attachment affecting the malignant potential of breast cancer cells via binding to integrin alphavbeta3., CtsH-mediated processing of talin might promote cancer cell progression by affecting integrin alphaVbeta3 activation and adhesion strength, CTGF increased IL-6 production in osteoarthritic synovial fibroblasts via the alphavbeta5 integrin, ASK1, p38/JNK, and AP-1/NF-kappaB signaling pathways., Integrins alphavbeta3 and alphavbeta5 and their ligands are expressed in distinct and heterogeneous patterns in primary and secondary central nervous system neoplasms., integrin alphavbeta5 might play an important role in invasion and metastases of laryngeal squamous cell carcinoma, study demonstrate that binding of integrin alphavbeta5 and alpha defensin 5 have opposite effects on the elastic response of adenovirus type 35, revealing a direct link between virus-host interactions and the mechanical properties of the capsid, alphavbeta8 integrin, via interactions with RhoGDI1, regulates activation of Rho proteins to promote glioblastoma multiforme cell invasiveness., Increased alphavbeta6 integrin expression is associated with poor prognosis and decreased survival in oral squamous cell carcinoma patients., Data indicate that EGFL7 and integrin alphavbeta3 integrin colocalized in vesicular structures in uman umbilical vein endothelial cells (HUVECs)., Our data indicate that expression of [alpha]v[beta]3 in tumor cells and vessels is dependent on tumor grade, and that its expression in tumor cells may have a prognostic impact., the integrin avb6 plays an important role in the fusion of endosome/lysosome in corneal epithelial cells; inhibition of avb6 results in corneal epithelial barrier dysfunction., Data suggest that the integrin alphaVbeta5 receptor is largely responsible for mediating the differentiation process in pancreatic cells., Results show that stromal cell-derived factor-1 (SDF-1) enhanced ovarian cancer cell invasion through alphavbeta6 integrin-mediated urokinase-type plasminogen activator (uPA) expression via the p38 MAPK and PI3 K/Akt pathway., Data indicate CCN1 can induce actin reorganization, formation of lamellipodia, and cell migration/invasion through the alphaV integrins/Rac1/ERK signaling axis; these CCN1-dependent activities can be effectively suppressed by monoclonal antibody YM1B., The coupling of extracellular matrices to integrin alphaV is necessary for Glioma initiating cell differentiation., Interaction of vitronectin with integrin alphavbeta3 results in the continued activation of the kinase mTOR., the expression of Lewis y antigen, integrin alphav and ovarian cancer's clinical stage are both independent, drug resistance-related risk factors., Exposure of smooth muscle cells to apo(a) in migration assays induced a potent, concentration-dependent chemorepulsion that was RhoA and integrin alphaVbeta3-dependent, but transforming growth factor beta-independent., Vinblastine resistance in renal cell carcinoma can be ascribed to the overexpression of P-gp, which is regulated by the activation of the PI3K/Akt pathway and triggered by upstream CCN1-integrin avb3 interaction., PDGFRalpha CD51 cells in fetal bone marrow represent a small subset of CD146 cells expressing Nestin and enriched for mesenchymal stem cell and hematopoietic stem cell niche activities., The alphavbeta5 integrin-FAK-mediated pathway regulates phagocytosis in trabecular meshwork cells and this pathway is inhibited by activation of alphavbeta3 integrins., A switchblade-like movement of the integrin leg is indispensable for the affinity regulation of alphaVbeta3 integrin., We report a protein expression profile in high-grade osteosarcoma associating beta5 integrin, FAK, and GSK3beta that significantly correlates with poor response to neoadjuvant chemotherapy., Interaction between CCL2 and CCR2 enhances migration of prostate cancer cells through an increase in alphavbeta3 integrin production, Real-time imaging of alphav integrin molecular dynamics in human 143B osteosarcoma cells in vitro and in vivo, is reported., The level of OPN expression in lung adenocarcinoma was associated with decreased apoptotic activity of tumor cells, and correlated with alphav integrin expression, particularly in low stage tumors., GIC lines and their derived differentiated cultures expressed CD95 on the cell surface and were sensitive towards APO010-mediated cell death to a variable extent, upregulation of alphavbeta6 on myoepithelial cells generates a tumor promoter function through TGFbeta upregulation of MMP-9. These data suggest that expression of alphavbeta6 may be used to stratify patients with DCIS., Brain metastases ITGAV expression exhibits considerable heterogeneity according to tumor origin., Complement C3, vitronectin, and apolipoprotein A-I were further confirmed by western blotting, and the results showed that their contents decreased significantly after transient limb ischemia., alphavbeta6- and alphavbeta8-integrins acted independently and are thus interchangeable as receptors for Herpes simplex type 1 virus entry., Results suggest that the ITGAV gene may be a candidate gene for the etiopathogenesis of rheumatoid arthritis., findings suggest that Alpha(v)Beta5 integrins and their natural ligand VN are involved in P. fluorescens adherence and invasion in human epithelial cells, [(18)F]Galacto-RGD PET/CT shows specific tracer accumulation in human atherosclerotic carotid plaques, which correlates with alphavbeta3 expression., Inhibition of integrin alphavbeta3 results in significant inhibition of trophoblast attachment., CCN2 and inflammatory cytokines form a functional negative feedback loop in NP cells involving interleukin-1beta through alpha5beta1 and alphaVbeta3 integrins that may be important in the pathogenesis of disc disease, alpha5beta1 and alphav integrins are essential for cell-cell fusion and hMPV infection., High integrin alphaVbeta3 expression is associated with hepatocellular carcinoma., cilengitide can significantly down-regulate ITGAV expression and inhibit cell proliferation in laryngeal cancer cells, it will also to induce cell apoptosis through caspase-3 pathway., Expression of Gli1 and alphavbeta6 inversely correlates in tumours in vivo, and Hh targeting up-regulates TGF-beta1/Smad2/3-dependent alphavbeta6 expression, promoting pro-tumourigenic cell functions in vitro., Integrins alphavbeta5 and alphavbeta3 both control myofibroblast differentiation by activating latent TGF-beta1, The use of LIF in combination with alphanubeta3 integrin as biomarkers appears to be superior to integrin testing alone when evaluating endometrial receptivity, primarily because of its earlier pattern of expression during the secretory phase., Overexpression of integrin alphav is associated with advanced T and N stage and as an independent prognostic factor in colorectal carcinoma., In pancreatic adenocarcinoma cells, PAR3 knockdown enhances cell adhesion. We propose this is due to increased expression of E-cadherin, leading to a greater adhesion of free-floating cells to cells bound to the surface via integrins, particularly ITGalphav., This co-targeting strategy relies on the interaction of MMP-2 with integrin a(v)b(3), which are known to associate via the hemopexin domain of MMP-2, These results suggest that AGM cooperates with VEGF to induce the aberrant functions of cancer vasculature as a ligand of integrin alpha5beta3., The increased surface expression of alpha5beta1 integrin, along with the adhesion between the cells and fibronectin, could be inhibited by both ataxia telangiectasia mutated (ATM) and Rad3-related (ATR) kinase inhibitors, Data show that chemokine domain of fractalkine (FKN-CD) can activate alphavbeta3 integrin in the absence of fractalkine receptor CX3CR1, but that this activation requires the direct binding of FKN-CD to alphavbeta3., Studies sugggest that the effect of integrin alphavbeta3 in the whole process of brain function recovery merits further study., Coimmunoprecipitation studies and proximity ligation assays indicated that integrin alphavbeta3 interacts with herpes simplex virus type 2 glycoprotein H (gH)., Herpesvirus 8 attachment and entry are dependent on alphaVbeta3 integrin localized to specific cell surface microdomains., alphavbeta3 was necessary and sufficient for Slug activation, the present study demonstrated that the link between systemic inflammatory markers and the ITGAV-rs3911238 polymorphism allele in Iranian RA patients., Expression of alphav integrin subunits seem to be of pathobiological and clinical relevance in patients with non-small cell lung cancer with brain metastases., The levels of integrin alpha(nu)beta(3) between normal skin and hypertrophic scar tissues were compared, and integrin alpha(nu)beta(3) was found to be upregulated in hypertrophic scar., overexpression of integrin alphav induces integrin alphavb8 heterodimer formation and the binding of integrin alphavbeta8 to type collagen might enhance the proliferation and invasion of SCC cells via the activation of the MEK/ERK signaling pathway., Suggest a role for cyclin D1b as a possible mediator of alphavbeta3 transcription to promote breast tumor metastasis., Inhibition of tumor-associated alphavbeta3 integrin regulates the angiogenic switch by enhancing expression of IGFBP-4 leading to reduced melanoma growth and angiogenesis in vivo., Low NAMPT is associated with upregulation of alphavbeta3 integrin in breast tumor cells., The importance of interaction between EDIL3 and integrin alphaV., The overexpression of ITGAV gene was associated with higher progression and spread of CRC via perineural invasion., Exogenous ATX controls breast cancer cell proliferation, invasion, and endothelial cell transmigration via interaction tumor integrin alphaVbeta3., post-treatment of peptides derived from the full-length tail or from the turn motif did not reverse aIIb and aV integrin activation., Unique sites of interaction between alphavbeta6 and uPAR are most likely located in uPAR domains II and III., The identification of integrin alphavbeta6 in a subset of DCIS presents a unique way to stratify patients with DCIS into those who may or may not progress to more serious disease., Integrin alphav promotes the proliferation of the human lung cancer cell line A549 by activating the ERK 1/2 signaling pathway, Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrin alphaVbeta3, integrin alphavbeta1, and integrin alpha4beta1., Integrin alphaVbeta3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells., suggest that the OPN-integrin alphavbeta3 axis is crucial for 5-FU resistance in oral scandalous cell carcinoma, Integrin alphavbeta3 is required for cathepsin B-induced hepatocellular carcinoma progression, Either mutation of two amino acids (D205A,D207A), or deletion of seven amino acids (Del202-208) of the Borrelia burgdorferi P66 protein significantly reduced binding ability to integrin alphavbeta3., alpha5beta1 and alphavbeta3 each mediate actin cytoskeletal remodeling in response to stiffening or cyclic stretching of the extracellular matrix., high levels of alphavbeta6 integrin may identify a specific endotype of progressive fibrotic lung disease, Osteopontin might promote a cancer stem cell-like phenotype via the alphavbeta3-NF-kappaB-HIF-1alpha pathway in hepatocellular carcinoma., alphav integrin is required for efficient TGF-beta/Smad signaling and TGF-beta-induced breast cancer cell migration, and for maintaining a mesenchymal phenotype of the breast cancer cells., The driving role of the tumour microenvironment on CRC dissemination, here detected, and described, strengthens and adds new value to the concept that a5b1 integrin can be an appropriate and relevant therapeutic target for the control of CRC metastases., our observations suggest that miR-25 is a key regulator of invasiveness in human prostate cancer through its direct interactions with av- and a6-integrin expression, Our results show that the acquisition of metastatic competence by melanoma cells is accompanied by alteration of alphavbeta3 integrin glycosylation and that both avb3 and b1-6-branched sialylated complex-type N-glycans promote metastatic melanoma migration, These results suggest that melatonin exerts anti-migratory and anti-invasive effects on glioma cells in response to hypoxia via reactive oxygen species-alphavbeta3 integrin-FAK/Pyk2 signaling pathways., targeting eIF4E in integrin avb6 expressing tumors can be a potential therapeutic strategy for patients with colon cancer., Herpes simplex virus entry is enabled by gH/gL interaction with alphavbeta6- or alphavbeta8-integrin receptors., ERK-mediated transcription regulation of the alphav monomer is regulated by T3. Thyroid hormones are potent alphavbeta3-ligands, driving ovarian cancer cell proliferation., The combined impacts of alphav-integrin and HER2 influence the invasive phenotype of breast cancer cells., These findings suggest that enhanced integrin alphavbeta3 expression in addition to enhanced FGFR1 expression is critical for FGF1 to augment TGF-beta1-induced EMT in mammary epithelial cells., Integrins alphavbeta6 and alphavbeta8 were expressed in non-overlapping patterns by keratinocytes and maintained the epidermal residence of Langerhans cells and tissue resident memory T cells by activating latent TGF-beta.,
OFFICIAL_GENE_SYMBOL ITGAV,
SP_COMMENT function:The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions., similarity:Belongs to the integrin alpha chain family., similarity:Contains 7 FG-GAP repeats., subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus (By similarity). Alpha-V/beta-6 binds to coxsackievirus A9 and coxsackievirus B1 capsid proteins and acts as a receptor for these viruses.,
integrin subunit beta 5(ITGB5) integrin subunit beta 5(ITGB5) Related Genes Homo sapiens
CHROMOSOME 3,
CYTOBAND 3q21.2,
ENSEMBL_GENE_ID ENSG00000082781,
GENERIF_SUMMARY Overexpression of the beta5 integrin in hematopoietic cells was associated with the inhibition of cell proliferation and apoptosis., identification of a new alphavbeta5 integrin-interacting motif that is highly conserved in the fas-1 domains of many proteins suggesting that fas-1 domain-containing proteins may perform their biological functions by interacting with integrins, alphav subunit cleavage is essential for integrin function and has a considerable impact on integrin-dependent events, especially those leading to cell migration, Data suggest that modulating the expression of integrin subunits beta3/5 in human neurons may enhance adenoviral infectivity via the coxsackie-adenovirus receptor., urokinase receptor-derived SRSRY peptide regulates cross-talk between fMLP and vitronectin receptors, different beta5 integrins, integrin alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 binding to osteopontin is controlled by specific structural motifs that are recognized by extracellular proteases, Expression of integrins alphavbeta1, alphavbeta3, and alphavbeta5 in cerebral arteriovenous malformations and cavernous malformations. (Integrins alphavbeta1, alphavbeta3, and alphavbeta5), While tolerogenic DCs are not induced via alphavbeta5, coligation of CR3 and alphavbeta5 maintains the DC's tolerogenic profile., Alphavbeta5 integrin may play a role in the adhesion and migration of VSMCs during the pathogenesis of atherosclerosis., upregulated expression of alphavbeta5 contributes to autocrine TGF-beta signaling in localized scleroderma fibroblasts, Cell surface expression of alphavbeta5 resulted in an attenuation of alphavbeta3-mediated migration on vitronectin, Our studies suggest that the phagocytic function of beta5 integrin is regulated by an unconventional NPxY-talin-independent activation signal and argue for the existence of molecular switches in the beta5 cytoplasmic tail for adhesion and phagocytosis., Real-time PCR showed that ETOH significantly altered the expression of genes involved in cell adhesion. There was an increase in the expression of alpha and beta Laminins 1, beta Integrins 3 and 5, Secreted phosphoprotein1 and Sarcoglycan epsilon., data identify PAI1 as a novel regulator of fibronectin matrix assembly, and indicate that this regulation occurs through a previously undescribed crosstalk between the alphavbeta5 and alpha5beta1 integrins, Oxidized LDL impairs angiogenic properties of endothelial progenitor cells at sub-apoptotic levels by downregulation of E-selectin and integrin alphavbeta5, both substantial mediators of EPC-endothelial cell, human umbilical vein endothelial cells adhere to immobilized CXCL4 through alphavbeta3 integrin, and also through other integrins, such as alphavbeta5 and alpha5beta1, urokinase-derived antagonists of alphavbeta5 integrin activation inhibit migration and invasion of carcinoma cells, The active site within the Sdc1 core protein was identified and a peptide inhibitor called synstatin (SSTN) that disrupts Sdc1's interaction with alpha(v)beta(3) and alpha(v)beta(5) integrins was derived., Compound 4, having the DGR retro-sequence, is a low micromolar ligand for the alphavbeta5 integrin., Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway, Beta1 integrins are required for adhesion and proliferation of induced pluripotent stem cells on matrigel. On vitronectin, the integrin alphavbeta5 is required for initial attachment, but both alphavbeta5 and beta1 is required for proliferation., The angiogenic effects of leptin are mediated by circulating angiogenic cells and involve src kinase dependent phosphorylation of integrin alphavbeta5., Definitive endoderm highly express the integrins alphaV and beta5, which have the ability to bind to vitronectin., Ovarian cancer ascites induces FAK and Akt activation in an alphavbeta5 integrin-dependent pathway, which confers protection from TRAIL-induced cell death and caspase activation., The beta5-integrin adhesions contribute to the TGFbeta-induced EMT and the tumorigenic potential of carcinoma cells., Src kinase-mediated activation of STAT3 and subsequent angiogenic gene expression mediate the effects of integrin alpha v beta 5 and may be exploited to enhance the paracrine activities of circulating angiogenic cells., p21-activated kinase 4 phosphorylation of integrin beta5 Ser-759 and Ser-762 regulates cell migration, Integrin alphavbeta5 is a primary receptor for adenovirus., Data show that knockdown of integrin alphav and erbB3 by small-interfering RNAs significantly inhibited cell migration induced by HRG., PAK4 is activated by cell attachment to vitronectin as mediated by PAK4 binding partner integrin alphavbeta5., beta5 integrin is identified as the most important partner of the alpha vitronectin-coupled integrin dimer in monocyte-derived macrophages, thus rendering these cells more susceptible to NF-kappaB-dependent HIV-1 infection., CCN3 enhances the migration of chondrosarcoma cells by increasing MMP-13 expression through the alphavbeta3/alphavbeta5 integrin receptor, FAK, PI3K, Akt, p65, and NF-kappaB signal transduction pathway., alphanubeta3 and alphanubeta5 have roles in photon-induced hypermigration of malignant glioma cells, Letter, Cysteine-rich protein Cyr61 activates interleukin (IL)-6 production via the alphavbeta5/Akt/NF-kappaB signaling pathway in rheumatoid arthritis., High beta5-integrin protein expression is associated with aggressive behavior in gastric cancer., knockdown of endogenous alphavbeta5 expression or treatment with a function-blocking alphavbeta5 antibody significantly decreased stabilin-2-mediated phagocytosis in the absence of soluble factors, Active MMP-2 regulates VEGF-A in melanoma cells on a transcriptional level via an integrin alphavbeta5/phosphoinositide-3-kinase-dependent pathway., Data indicate the role of CYR61 and alpha(V)beta5 integrin as proteins that cooperate to mediate cancer cell migration., Depletion of integrin beta5 in triple-negative breast carcinoma cells markedly reduced tumor take, growth and tumor angiogenesis, whereas reexpression of integrin beta5 rescued this phenotype; findings show a critical role for integrin beta5 in the tumorigenic potential of breast carcinoma cells, These studies implicate ASM as a mediator of apoptosis induced by inhibition of integrins alphavbeta3/alphavbeta5, and for the first time place c-Abl as an upstream regulator of ASM expression and activity., Saccharomyces boulardii supernatant contains motogenic factors that enhance cell restitution through multiple pathways, including the dynamic fine regulation of alphavbeta5 integrin binding activity., CTGF increased IL-6 production in osteoarthritic synovial fibroblasts via the alphavbeta5 integrin, ASK1, p38/JNK, and AP-1/NF-kappaB signaling pathways., integrin alphavbeta5 might play an important role in invasion and metastases of laryngeal squamous cell carcinoma, study demonstrate that binding of integrin alphavbeta5 and alpha defensin 5 have opposite effects on the elastic response of adenovirus type 35, revealing a direct link between virus-host interactions and the mechanical properties of the capsid, Data suggest that the integrin alphaVbeta5 receptor is largely responsible for mediating the differentiation process in pancreatic cells., BDNF enhances the migration of chondrosarcoma by increasing beta5 integrin expression through a signal transduction pathway that involves the TrkB receptor, PI3K, Akt, and NF-kappaB., molecular model of integrin b5 structure was prepared and stereo chemical model quality was checked. Integrin b5 active sites were identified based on insilico analysis tools., The top primary GWAS association of Airway hyperresponsiveness was in rs848788(P-value 7.2E-07) located within the ITGB5 genes., Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta., Brain metastases ITGB5 expression exhibits considerable heterogeneity according to tumor origin., findings suggest that Alpha(v)Beta5 integrins and their natural ligand VN are involved in P. fluorescens adherence and invasion in human epithelial cells, we demonstrated via antibody blocking experiments that aV b5 and a6 significantly promoted hESC attachment in 2%oxygen only, whereas blockage of CD44 inhibited cell attachment in 21% O2 alone, Integrins alphavbeta5 and alphavbeta3 both control myofibroblast differentiation by activating latent TGF-beta1, FAK activity regulates beta5 integrin expression and anchorage-independent cell growth in ovarian carcinoma., Myo7a interacts with integrin beta5 and selectively promotes integrin alphavbeta5-mediated cell migration, Immunohistochemical analysis for alphavbeta3, alphavbeta5 and alphavbeta6 integrin subunits was performed and correlated with Ki67 and hypoxia-inducible factor (HIF)-1alpha indexes, FRMD5 regulates tumor cell motility via a dual pathway involving FRMD5 binding to integrin beta5 tail and to ROCK1, ITGA3, ITGA6, ITGB3,ITGB4 and ITGB5 are associated with GC susceptibility (rs2675), ITGA3, ITGA6, ITGB3, ITGB4 and ITGB5 are associated with gastric cancer susceptibility tumor stage and lymphatic metastasis in Chinese Han population, Data suggest that the binding, but not the internalization of photoreceptor outer segments (POS) confers protective effects on retinal pigment epithelium (RPE) cells through the alphavbeta5 integrin/focal adhesion kinase (FAK)/PGC-1alpha pathway.,
OFFICIAL_GENE_SYMBOL ITGB5,
SP_COMMENT function:Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand., similarity:Belongs to the integrin beta chain family., similarity:Contains 1 PSI domain., similarity:Contains 1 VWFA domain., subunit:Heterodimer of an alpha and a beta subunit. Beta-5 associates with alpha-V.,
syndecan 1(SDC1) syndecan 1(SDC1) Related Genes Homo sapiens
CHROMOSOME 2,
CYTOBAND 2p24.1,
ENSEMBL_GENE_ID ENSG00000115884,
GENERIF_SUMMARY The loss of syndecan-1 expression evident in acantholytic conditions, mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma, Serum levels of soluble syndecan-1 correlated with tumor mass in patients with multiple myeloma., Soluble syndecan-1 promotes growth and dissemination of transplanted human myeloma tumors in vivo in SCID mice implanted with human bones., review of structure, function, cell and tissue distribution, regulation of expression in isoform specific manner by farnesoid X receptor, Cells adherent via syndecan-1 do not spread, but can be induced to spread by Mn(2+), suggesting that activation of a beta(1) or beta(3) integrin partner is required., TNF-alpha and IL-1beta are capable of down-regulating syndecan-1 expression, High syndecan-1 expression in breast carcinoma is related to an aggressive phenotype, shedding of syndecan-1 promoted by MT1-MMP through the preferential cleavage of Gly245-Leu246 peptide bond stimulates cell migration, The increased stromal syndecan-1 expression, coupled with its loss from the surface of carcinoma cells, may contribute to tumor cell invasion and the development of metastases, results demonstrate that the laminin alpha3 LG4/5 modules within unprocessed laminin-5 permit its cell binding activity through heparan and chondroitin sulfate chains of syndecan-1, the extracellular domain mediates an interaction that is necessary for dynamic cytoskeletal rearrangements whereas an interaction of the transmembrane domain is required for the initial spreading response, results demonstrate that cell-surface syndecan-1 is a degradative target of heparanase (HPSE-1), and syndecan-1 regulates HPSE-1 biological activity, serves as a primary human papillomavirus receptor protein in natural HPV11 infection of keratinocytes., MT4-MMP and the proteoglycan form of syndecan-1 have roles in ADAMTS-4 activation on the cell surface, Growth-promoting loop exists between breast cancer cells and their stroma that depends on the activity of glycanated Sdc1., Consistent with a possible biochemical role for syndecan-1 in prostate cancer progression and metastasis, syndecan-1 expression correlated with serologic recurrence in Gleason sum 7 prostate cancer and was highly expressed in soft-tissue metastases., in hyperinflammatory lesions, ephrinB2 was predominantly expressed in macrophage-like cells and EphB4 in small venules; syntenin and syndecan-1 were up-regulated in EphB4-positive endothelial cells after stimulation with preclustered ephrinB2, syndecan-1 and glypican-1 have roles in progression of ovarian cancer, Altered matrix-dependent signaling due to increased levels of cell surface syndecan-1 may lead to epithelial cell invasion during early stages of tumorigenesis., Concomitant expression of syndecan-1 in both epithelium and stroma may be a predictor of unfavourable prognosis in breast cancer, and in contrast with previous studies, loss of epithelial syndecan-1 was associated with a more favourable prognosis, syndecan-1 is likely to be a critical regulator of many cellular behaviors that depend on activated alpha(v)beta(3) integrins, constitutive shedding corresponding to the basal level of soluble syndecan-1 ectodomain was significantly increased when cells were stimulated with P. gingivalis lipopolysaccharide, osteoprotegerin affects monocyte mi-gration and protein kinase C and phosphatidylinositol 3-kinase/Akt activation via syndecan-1., syndecan-1 has a role in progression of invasive breast carcinomas through the remodeling of breast cancer tissue via interaction with other extracellular matrix components, Expression of paxillin and syndecan-1 in hepatocellular carcinoma(HCC) may affect its invasive and metastatic ability. May be converse correlation between expression of paxillin and syndecan-1 protein in HCC., Stromal syndecan-1 expression is an independent prognostic marker in pancreatic cancer, whereas epithelial syndecan-1 expression predicts better prognosis only in resectable disease., Loss of syndecan-1 plays a role in the growth of G-type cancers of differentiated type gastric cancers at an early stage, Low epithelial syndecan-1 expression was associated with a higher histological grade and a more advanced clinical stage of the colorectal cancer, Malignant glioma cells express all types of syndecans. NF-kappaB participates in the upregulation of the syndecan-1 expression at the transcriptional level, and increased expression of syndecan-1 could associate with thrombospondin-1., stromal fibroblast-derived Sdc1 stimulates breast carcinoma growth and angiogenesis in vivo, shed syndecan-1 or MMP7-syndecan-1 complexes may have roles in tumor progression, Syndecan-1 and syndecan-4 may have roles in progression of breast carcinoma, The ectodomain of the syndecan-1 core protein contains an active site that assembles into a complex with the alphavbeta5 integrin and regulates alphavbeta5 integrin activity., Certain immunomarkers like syndecan-1, kappa and lambda light chains and IgA heavy chain could be of much help in identifying early stage immunoproliferative small intestinal disease (IPSID)., CD138 may have a role in progression of nodal diffuse large B cell lymphoma, syndecan-1 may have a role in progression of B-cell chronic lymphocytic leukemia, increase of Syndecan-1 in all tissue compartments and a redistribution from epithelium to stroma may be a characteristic feature for dense breast tissue, syndecan-1 shedding may modulate the pathogenesis of specific microbes, the endocytic path taken by Syn-1 is clathrin-independent and relies upon lipid raft function, Lacritin targets the deglycanated core protein of SDC1 and not HS chains or SDC2 or SDC4. Binding requires partial or complete removal of HS chains by endogenous HPSE. This limits lacritin activity to HPSE release sites as an HPSE 'off/on switch'., Syndecan-1 expression is uniquely influenced by changes in the phase and magnitude of the local stress field., domain V of the gamma2 chain negatively regulates the integrin beta4 phosphorylation, probably through a syndecan-1-mediated signaling, leading to enhanced cell adhesion and suppressed cell motility, Heparanase influences expression and shedding of syndecan-1, In summary, ovarian carcinomas exhibit up-regulated expression of several extracellular matrix proteins, and syndecan 1 represents a novel tumor-associated marker in ovarian serous carcinomas., Decreased syndecan-1 is asociated with thyroid cancer, upregulation of syndecan-1 may be a critical element for endometrial cancers in maintaining their viability, SDC1 interaction with the LG4/5 domain in kalinin is essential for keratinocyte migration., syndecan-1 regulates keratinocyte proliferation differently during skin development and in healing wounds., Results indicate a lack of association between SDC-1 polymorphisms and risk of squamous cell carcinomas of the cervix., heparan sulfate and syndecan-1, the predominant intestinal epithelial heparan sulfate proteoglycan, are essential in maintaining intestinal epithelial barrier function., syndecan TMD homodimerization and heterodimerization can be mediated by GxxxG motifs and modulated by sequence context, the association of circulating sCD138 levels in plasma with clinical behavior in 104 patients with chronic lymphocytic leukemia, Syndecan-1 and beta1 integrin signaling downstream of laminin alpha1-derived peptide AG73 regulate adhesion and MMP production by human salivary gland tumor cell lines (CAC2 and M1)., aberrant skin expression may be involved in the development of psoriasis, n-3 polyunsaturated fatty acids (n-3 PUFA) upregulate SDC1 in breast cancer cellsbu activating PPARgamma, providing a chemopreventive effect., In vitro reconstructed normal human epidermis expresses differentiation-related proteoglycans (CD44, syndecan-1, desmosealin, and 7C1)., syndecan 1 is up-regulated by n-3 fatty acids by a transcriptional pathway involving PPARgamma, loss of syndecan-1 epithelial expression was of strong prognostic value in breast carcinomas, Our findings thus suggest that a previously unknown link between integrin alpha2beta1 and syndecan-1 is important in regulating cell adhesion to collagen and in triggering integrin downstream signalling., CD138 is a new simple non-invasive marker for predicting liver fibrosis in patients with chronic hepatitis C., Rab5 is a critical regulator of syndecan-1 shedding that serves as an on-off molecular switch through its alternation between the GDP-bound and GTP-bound forms., Expression of Galectin-3, CD138, p16INK4a, and TTF-1 in mucinous bronchioloalveolar adenocarcinoma after Hodgkin lymphoma., Membrane type 1 matrix metalloproteinase-mediated stromal syndecan-1 shedding stimulates breast carcinoma cell proliferation., syndecan-1 directly contributes to the growth and invasive ability of oral cancer cells, Plasma levels of syndecan-1 increased significantly during coronary artery bypass grafting, with or without the use of cardiopulmonary bypass., Oxidative shedding of syndecan-1 is an underlying cause of neutrophil chemotaxis and aberrant wound healing that may contribute to pulmonary fibrosis., Proteolytic conversion of Sdc1 from a membrane-bound into a soluble molecule marks a switch from a proliferative to an invasive phenotype, with implications for breast cancer diagnostics and potential glycosaminoglycan-based therapies., Data show that syntenin-1 binds to syndecan-1 and participates in the formation of membrane protrusions, and that syntenin-1 recruitment depends on the dephosphorylation of Tyr-309 located within syndecan-1 PDZ binding domain EFYA., Shed syndecan-1 restricts neutrophil elastase from alpha1-antitrypsin in neutrophilic airway inflammation., The active site within the Sdc1 core protein was identified and a peptide inhibitor called synstatin (SSTN) that disrupts Sdc1's interaction with alpha(v)beta(3) and alpha(v)beta(5) integrins was derived., Results show that heparanase alters the level of nuclear syndecan-1., The present results suggest that the decrease in syndecan-1 expression and increase in the Ki-67 index observed in ameloblastic carcinomas is in accordance with its higher aggressiveness as compared to the rare desmoplastic and peripheral ameloblastomas., reduced syndecan-1/E-cadherin expression may be good indicators of recurrence and prognosis in extrahepatic bile duct carcinoma., changes in the pattern expression of syndecan-1 and -2 indicate that both molecules may be involved in the epithelial-mesenchymal transition (EMT) and tumor progression of prostate cancer., syndecan-1 is a co-receptor for APRIL and TACI at the cell surface of MMC, promoting the activation of an APRIL/TACI pathway that induces survival and proliferation in multiple myeloma cells, Results showed that epithelial syndecan-1 expression is reduced as lip carcinogenesis progresses (normal tissue>actinic cheilitis>lip squamous cell carinoma), suggesting that syndecan-1 could be a useful marker of malignant transformation in the lip., Ressutls show that cystic tumors of the pancreas express syndecan-1 and tenascin differently and suggest that low syndecan-1 expression might serve as a predictive factor for malignancy., the effects of syndecan-1 on myeloma survival, growth, and dissemination are due, at least in part, to its positive regulation of tumor-host interactions that generate an environment capable of sustaining robust tumor growth., Study indicates that SDC-1 and -4 may be required for HepG2, Hep3B and Huh7 human hepatoma cell migration, invasion or spreading induced by the chemokine., syndecan 1 and 4 correlate to increased metastatic potential in melanoma patients and are an important component of the Wnt5A autocrine signaling loop, Chronic inflammation and exogenous insulin usage increases the serum syndecan-1 level in type 2 diabetics., syndecan-1 and FGF-2, but not FGFR-1 share a common transport route and co-localize with heparanase in the nucleus, and this transport is mediated by the RMKKK motif in syndecan-1, Data report that the bFGF, FGFR1/2 and syndecan 1-4 expressions are altered in bladder tumours., syndecan-1 might contribute to urothelial carcinoma cell survival and progression, higher proportion of protein-expressing B-cells in the blood of patients with systemic lupus erythematosus, ADAM17 may therefore be an important regulator of syndecan functions on inflamed lung epithelium., Sdc1 has a protective effect during experimental colitis., High CD138 serum levels are associated with B-chronic lymphocytic leukemia progression., Data substantiate the existence of a co-adhesion receptor system in tumor cells, whereby Sdc1 functions as a key regulator of cell motility and cell invasion by modulating RhoA and Rac activity., Age-associated study of detailed characterization of circulating CD138-negative and CD138-positive plasma cells sorted by flow cytometry shows a typical plasma cell cytology with no obvious morphological differences., all syndecans can interact with proteins of the actin-associated cytoskeleton--REVIEW, pathway driven by heparanase expression in myeloma cells, Decreased expression of Syndecan-1 mRNA and the increased expression of HPA-1 mRNA can promote the invasion and metastasis of colorectal cancer., Syndecan-1 shed by tumor cells exerts biologic effects distal to the primary tumor and that it participates in driving osteoclastogenesis and the resulting bone destruction., Syndecan-1 and versican expression status can serve as an indicator of prognosis in patients with epithelial ovarian cancer., Laminin-derived peptide AG73 regulates migration, invasion, and protease activity of human oral squamous cell carcinoma cells through syndecan-1 and beta1 integrin., The presence of a less mature, more resistant CD138-negative myeloma cell fraction within bone marrow microniches might contribute to high incidence of relapse of myeloma patients., Cell biological analysis established that Syndecan1 is a physiological binding partner of Tiam1 and that the PDZ domain has a function in cell-matrix adhesion and cell migration., Expression of syndecan 1 in healthy breast tissue during menstrual cycle., Results suggest a role for syndecan-1 and cathepsins D and K in growth and invasiveness of esophageal squamous cell carcinoma., This study confirms a direct relationship between suprabasal p35 localization together with down-regulation of syndecan-1 immunoexpression and dysplastic changes of oral lichen planus and hence the possibility for malignant transformation., The prognostic value of intraepithelial and stromal CD3-, CD117- and CD138-positive cells in non-small cell lung carcinoma., The syndecan- and alpha2beta1 integrin-binding peptides synergistically affect cells and accelerate cell adhesion., multiple regression analysis showed that apolipoprotein A1 was a predictor of serum syndecan-1 levels in subjects with type 2 diabetes, A threshold of greater than six CD138+ metabolically active plasma cells is associated with poor kidney allograft function and survival., Loss of SDC-1 is associated with prostate cancer., couples the insulin-like growth factor-1 receptor to inside-out integrin activation, These results demonstrate that syndecan-1 and syndecan-2 gene silencing by RNA interference reduces HSV-1 entry, plaque formation and facilitates cell survival., SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis, High glucose can decrease the expression of core protein Sydecan-1 and Glypican-1 in cultured human renal glomerular endothelial cells., In benign samples, syndecan-1 was expressed in basal and secretory epithelial cells with basolateral membrane localisation. In prostate cancer samples syndecan 1 was expressed to granular-cytoplasmic localisation., sCD138 may be applicable as a surrogate marker of disease activity., A multiple regression analysis showed that BMI (beta = 0.783, P < 0.000) was a significant predictor of positive syndecan-1 neutrophils in subjects with type 2 diabetes., Extracellular superoxide dismutase protects cardiovascular syndecan-1 from oxidative shedding and prevents from its subsequent induction of fibroblast proliferation., Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion, There was a statistical relationship between syndecan-1 presence in high-grade tumors and absence of syndecan-4, whereas syndecan-4 presence in cases positive for estrogen and progesterone receptor associated with syndecan-1 absence, In conclusion, CD138 expression may constitute an additional aid in the distinction between WM and SMZL., Findings show significant correlations between MMP-2, -9, and syndecan-1 and hemostatic parameters in hematologic malignancies, in contrast, the MMP inhibitors, TIMP1- and -2, were not correlated with any of the hemostatic parameters., Syndecan-1 is up-regulated in BeWo cells during differentiation and its silencing inhibits syncytialization., CD138 may contribute to the differential diagnosis of renal tumors, syndecan-1 regulates mesenchymal tumor cell adhesion and migration, and different domains have differential effects., Heparanase-mediated loss of nuclear syndecan-1 enhances histone acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive tumor phenotype, In trauma patients, high circulating syndecan-1, a marker of endothelial glycocalyx degradation, is associated with inflammation, coagulopathy and increased mortality., These data suggest that plasma based resuscitation preserved endothelial syndecan-1 and maintained endothelial integrity., Syndecan-1 mediates hepatic VLDL turnover in humans as well as in mice and shedding might contribute to hypertriglyceridemia in patients with sepsis., a new role for syndecan-1 in HSV-1 pathogenesis, results suggest that syndecan-1 may contribute to the highly angiogenic phenotype of MMECs by promoting EC proliferation, survival and modulating VEGF-VEGFR-2 signalling, Heparanase and syndecan-1 interplay orchestrates fibroblast growth factor-2-induced epithelial-mesenchymal transition in renal tubular cells., We found increased vascular adhesion protein 1 activity and anchor protein syndecan-1 content in critically ill patients with septic shock, Syndecan-1 expression was increased in tubular epithelial cells in allografts. Increased syndecan-1 in allografts correlated with low proteinuria and serum creatinine, less interstitial inflammation, less tubular atrophy and prolonged graft survival., Syndecan 1 and syndecan 2 are cellular molecules responsible for susceptibility to HTLV-1., Heparan sulfate chains of syndecan-1 regulate ectodomain shedding., Our results demonstrate that syndecan plays a negative role in death receptor-mediated cell death, CD138 reactivity for neoplastic cells in bone is not a definitive marker for plasmacytic origin., the LAMA3 LG45 domain may trigger different signals toward keratinocytes depending on its interaction with syndecan-1 or -4., Placental syndecan-1 expression is associated with premature birth and fetal growth., syndecan-1 is a novel target of the oncomiR miR-10b., We conclude that serum levels of HGF, OPN, and SYN correspond to the activity of MM and might become useful in differentiation of MGUS, asymptomatic MM, and overt/symptomatic form of MM., Data indicate that immune-magnetic CD138-positive cell sorting significantly increased the percentage of abnormal cells identified in FISH analysis of multiple myeloma (MM) samples., study adds new components to the multi-dentate membrane targeting mechanism and highlights the role of N- and C-terminal PDZ extensions of PSD-95/ZO-1 in the regulation of syntenin-1 plasma membrane localization, Mucosal TNF-alpha is overexpressed only in symptomatic diverticular disease, while SD1 and bFGF are already overexpressed in asymptomatic diverticulosis., The loss of syndecan-1 expression in the epithelial cell membrane is associated with tumor cell growth and invasiveness, the increased expression of syndecan-1 at gene and protein levels is correlated with advanced tumor progression and poor outcome in patients with glioma. Syndecan-1 might serve as a potential prognosis predictor of this dismal tumor., Report demonstrates that syndecan-1 enhances malignancy of a mesenchymal tumour cell line, via induction of syndecan-2 expression., observations suggest that low CD138 expression in multiple myeloma cells relates to poor prognosis, immature phenotype and low sensitivity to lenalidomide, Syndecan-1 alters the dynamic exchange of adhesion complex proteins, which in turn regulates migration speed., Novel processed form of syndecan-1 shed from SCC-9 cells plays a role in cell migration, the lung epithelium requires the syndecan-1 transmembrane domain to govern cell migration and is independent from its ability to control cell adhesion via the extracellular domain., Positive expression of BCL-6, CD10, CD138 and MUM-1 was shown in 78%, 61%, 39% and 91% of the cases., findings demonstrate that 15-LOX-1-mediated metabolism of DHA is required for it to upregulate SDC-1 and trigger the signaling pathway that elicits apoptosis in prostate cancer cells, Data indicate that Syndecan-1 silencing had less powerful effect on the transcriptome compared to overexpression., Syndecan-1, a target of miR-10b, inhibits epithelial endometriotic cell invasiveness through down-regulation of metalloproteinase activity and interleukin-6., Sdc-1 silencing promotes increased MDA-MB-231 cell migration via a beta1-integrin-dependent mechanism., IGF1R coupled with Sdc1 is required for activation of the alphaVbeta3 integrin and for VEGFR2 signalling., The DNA methylome of CD138-positive cells from 56 subjects representing premalignant (monoclonal gammopathy of uncertain significance), early, and advanced stages of myeloma, as well as healthy controls, is characterized., SDC1 expression was not different in patients with advanced vs no/limited LBD.A significant positive correlation between gene expression & BM plasma protein levels was observed for SDC1., Targeting of heparanase-modified syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel hybrid binding site that enhances selectivity., Elevation of serum SDC1 is associated with Crohn's disease., The assessment of syndecan-1 and Ki-67 expression in skin biopsies is a helpful tool for differentiating keratoacanthoma and squamous cell carcinoma, Data indicate that desmoplakin (DSP) and cystatin A (CSTA) interaction and insulin-like growth factor 1 (IGF-1), IGF-binding protein 7 (IGFBP7) and syndecan 1 (SDC1) interaction were observed in protein-protein interaction (PPI) network., SDC1 expression is associated with N stage and the status of resection margin involvement in squamous cell carcinoma (SCC) of the tonsil., High syndecan-1 levels in acute myeloid leukemia are associated with bleeding, thrombocytopathy, endothelial cell damage, and leukocytosis., Our studies demonstrates that SDC1 is the major receptor protein for HCV attachment., results indicate that angiogenesis induced by radiotherapy is associated with an MMP-9-miR-494-SDC1 regulatory loop, Through phenotype analysis, non-HAV-specific antibody-secreting cells are found to be Ki-67lowCD138highCD31highCD38high compared with HAV-specific ASCs., Comparative characteristics of the structure and function for syndecan-1 from animal organisms, Results suggest that small subsets of circulating CD30+/CD15+ cells expressing FGF2 and SDC1 represent biomarkers that identify NS-cHL patients who will experience a poor outcome., Data indicate that biochemical markers significantly associated with mesothelioma were hyaluronan, N-ERC/mesothelin and syndecan-1., Data indicate that the CD138int follicular B cells were clearly distinct from plasma cells., Syndecan-1 overexpression is associated with nonluminal subtypes and poor prognosis in advanced breast cancer., Chemotherapy stimulates syndecan-1 shedding, placental expression decreased in pre-eclampsia, independent of labor, gestational age, birthweight centile, SD1 mRNA levels do not differ between resected colon samples of patients with acute colonic diverticulites and ileocolonic Crohn's disease., Transfection of chimeric anti-CD138 gene enhances natural killer cell activation and killing of multiple myeloma cells., Syndecan-1 modulates the cancer stem cell phenotype via regulation of the Wnt and IL-6/STAT3 signaling pathways, It is concluded that increased SNAIL levels in advanced PC are associated with low expression of syndecan 1, Urinary levels and cellular localization of syndecan-1 are associated with differentiation status of patients with bladder cancer., Syndecan-1 (CD138) contributes to prostate cancer progression by stabilizing tumour-initiating cells., Presence of SDC1 in tumor stroma is an independent risk factor for patient survival in bladder cancer, this study revealed a link between miRNA-143 and Syn-1 in the pathogenesis of melanoma., Heptatitis c virus uses apoE-SDC4 interactions to enter hepatoma cells and establish infection., Expression decreased with the decreasing grades of dysplasia. Syndecan-1 can be efficiently used in early detection and diagnosis of oral carcinoma., Data indicate that the extracellular and cytoplasmic domains of syndecans 1/2/3/4 are intrinsically disordered regions., HO-1, S100A4, and SYND1 expressions have prognostic value in primary non-muscle-invasive bladder cancer (NMIBC)., Syndecan 1 mRNA expression did not vary between chronic diverticulitis and Crohn's disease., In DCIS of different nuclear grades, tissue localization of syndecan-1 is significantly divergent, suggesting a specific effect on biology and progression of DCIS., Increased syndecan-1 expression levels may indicate a high degree of differentiation, an early clinical stage and a favorable prognosis of malignant gastric cardiac adenocarcinoma., Elevated levels of soluble CD138/Sdc-1 in older bladder cancer patients and those with muscular invasion sheds some light on the mechanisms of the disease invasion., Syndecan-1 is involved in morphogenesis of the developing tooth crown and cervical loops, andntogether with CK8 and vimentin in differentiation of preameloblasts and preodontoblasts., syndecan-1 in pleural effusions predicted a survival difference for patients with pleural metastatic disease and malignant mesothelioma., syndecan-1(+) cell syncytia and excess GAG production recapitulate elements of the invertebrate encapsulation reaction, itself dependent on insect transglutaminase and glutaminated early response proteins, Sdc1 is required for HER2-mediated activation of the alpha6beta4 integrin in wound healing assays or tumor cell survival., PKC-mediated syndecan-1 downregulation causes loss of cell invasiveness in melanoma cells under anchorage independency, bFGF, SD1 and TNF-alpha are significantly reduced in Crohn's disease patients in deep remission under treatment with anti-TNFalpha, likely as an expression of optimal control of inflammation., syndecan-1 may have a role as a biological and prognostic marker in patients with triple-positive breast carcinomas, The levels of expression of VEGF and syndecan-4 mRNAs were significantly and positively correlated in cartilage explant but not in cultured chondrocytes, High Syndecan-1 expression is associated with chemotherapy resistance in colorectal cancer., High expression of SDC1 is associated with dedifferentiated liposarcoma tumorigenesis., Our study indicates that SDC1 expressed by the bone marrow microenvironment is involved in angiogenesis in MM., A significant association between SDC1 and breast cancer was identified., this work has broad implications beyond myeloma because shed syndecan-1 is present in high levels in many tumor types as well as in other disease states., Syndecan-1 responsive microRNA-126 and 149 regulate cell proliferation in prostate cancer, Serum SDC-1 levels are increased in systemic lupus erythematosus patients with nephritis, indicating that SDC-1 might be a useful serum biomarker for active LN., Syndecan-1 expression is associated with tumor size and EGFR expression in colorectal carcinoma, This paper provides evidence of alternative binding of IL-34 to chondroitin sulphates and syndecan-1 at the cell surface that modulates M-CSFR activation., our findings identify heparanase as a modulator of the syndecan-syntenin-ALIX pathway, fostering endosomal membrane budding and the biogenesis of exosomes by trimming the heparan sulfate chains on syndecans, syndecan-1 has a role in glycocalyx shedding and is increased in patients with end-stage liver disease; ischemia-reperfusion injury during OLT further exacerbates glycocalyx shedding, Sdc-1 may act as a modulator of ESC apoptosis and probably invasion depth as a crucial factor for successful pregnancy., The concentration of syndecan-1, a marker of glycocalyx damage measured during ED admission, is valuable in assessing the risk of developing AKI and in-hospital mortality., Elevated plasma syndecan-1 levels in renal transplantation patients might be interpreted as repair/survival factor related to loss of tubular and endothelial function in transplanted kidneys., Despite presence of the HPV-receptor syndecan-1 in tongue squamous cell carcinoma (TSCC), HPV prefers the tonsillar environment., miR-302a plays a key role in inhibition of ovarian cancer cell proliferation, and enhancing apoptosis by targeting SDC1., SULF1 levels are lower in pleural malignancies compared to benign conditions and inversely correlate with the amounts of syndecan-1, suggesting important roles for syndecan-1 and SULF1 in malignant mesothelioma., HPV16 particles binds to heparan sulfate and syndecan-1 molecules present in the extracellular matrix., demonstrate that HER2 is captured via a site, comprised of amino acids 210-240, in the extracellular domain of human Sdc1, and EGFR is captured via an extracellular site comprised of amino acids 87-131 in human Sdc4, Targeting Syndecan-1, a molecule implicated in the process of vasculogenic mimicry, enhances the therapeutic efficacy of the L19-IL2 immunocytokine in human melanoma xenografts., stromal changes in the expression of SDC-1 may originate from the stroma and contribute to the pathogenesis and metastatic potential of epithelial ovarian carcinoma, miR-145 suppresses syndecan-1 and, by this mechanism, up-regulates stem cell factors and induces cell senescence and differentiation., The new markers were able to identify a clonal CD138-negative population as minimal residual disease in the bone marrow and peripheral blood of MM patients., Syndecan-1 on epithelial tumor cells promotes MIF binding and MIF-mediated cell migration. This may represent a relevant mechanism through which MIF enhances tumor cell motility and metastasis., The results suggest that Sdc1 may modulate fibronectin fibrillogenesis and/or alter cell morphology during ECM production through alphavbeta3 integrin, thereby mediating ECM fiber alignment., The detection of syndecan-1 in endometrial cancer of different clinical and histological stages could be of prognostic value in clinical diagnosis.,
SP_COMMENT function:Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix., similarity:Belongs to the syndecan proteoglycan family., subunit:Interacts with CDCP1.,
transforming growth factor beta 1(TGFB1) transforming growth factor beta 1(TGFB1) Related Genes Homo sapiens
CHROMOSOME 19,
CYTOBAND 19q13.2, 19q13.2|19q13.1,
ENSEMBL_GENE_ID ENSG00000105329,
GENERIF_SUMMARY downregulates expression of integrin alpha6 in lens epithelial cells; gene expression regulation, Association of polymorphisms with genetic susceptibility to osteoporosis, Association of polymorphisms of the transforming growth factor-beta1 gene with the rate of progression of HCV-induced liver fibrosis., Transforming growth factor beta-1 stimulates invasivity of hepatic stellate cells by engagement of the cell-associated fibrinolytic system, Ectopic expression of eIF-4E in human colon cancer cells promotes the stimulation of adhesion molecules by transforming growth factorbeta, PAI-1 gene activation by TNF-alpha apparently is yet to be defined for the location of the response element and/or the signaling pathway, while TGF-beta is the most important cytokine for PAI-1 transcriptional activation through its 5' proximal promoter., decrease in p21cip1 levels was mediated by a TGFbeta-initiated Ras-dependent, but smad-independent post-transcriptional mechanism, effect on renal function of polymorphism in heart transplant recipients, Human TGF-beta1 induces an accumulation of connexin43 in a lysosomal compartment in bovine endothelial cells., TGF-beta1 is the predominant isoform in lymphoid organs and regulates autoimmunity and inflammation. Smad proteins 2,3,4,6,& 7 are involved in its signal transduction pathways., The induction of apoptosis by a combined 1,25(OH)2D3 analog, EB1089 and TGF-beta1 in NCI-H929 multiple myeloma cells., induction in keratinocytes after gamma irradiation, TGFbeta can promote DNA instability through down-regulation of Rad51 and inhibition of DNA repair., Dendritic cells exposed in vitro to TGF-beta1 ameliorate experimental autoimmune myasthenia gravis.TGF-beta1 promotes dendritic cell differentiation and maturation., S. stercoralis patients with HTLV-I showed a high frequency of expression of TGF-beta-1, but those without HTLV-I did not., decreased levels of active TGFb in HIV, and immunosuppresed patients, and in patients with Pneumocystis carinii pneumonia, REVIEW, TGFbeta1-induced parathyroid hormone-related protein(PTHrP)mRNA stability might be, in part, the result of cis-acting sequences within the coding region of the PTHrP mRNA., Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1., common TGF-beta1 polymorphisms are not associated with a risk of developing Dupuytren's disease., TGF-beta 1 expression level can be a risk factor for alcoholic liver disease and might be related to the inflammatory activity and fibrosis of the liver in patients., down-regulated UPA in normal and dystrophic myoblasts; was the only growth factor tested able to exceptionally up-regulate PAI-1, mainly in dystrophic satellite cells; and induced a dose-dependent increase of Matrigel invasion only in dystrophic myoblasts, results suggest the importance of alphaEbeta7 expression by TGF-beta in selective localization of intestinal intraepithelial T lymphocytes, no correlation between the concentration of either isoform of TGFbeta in milk and the corresponding TGFbeta in plasma, production by different populations of erythroid cells derived from human embryonal liver, Transforming growth factor-beta1 enhanced smooth muscle actin expression in TR-PCT1 cells, but this expression was reduced by subsequent treatment with basic fibroblast growth factor., TGF-beta(1) expression was significantly correlated with both hepatic fibrosis and the percentage of portal tracts showing histological abnormalities associated with cystic fibrosis liver disease., TGF beta 1 was able to suppress the expression of Id-1, a helix-loop-helix (HLH) protein, which plays important roles in the inhibition of cell differentiation and growth arrest., TGF-beta1, TGF-beta2 and TGF-beta3 isoforms are produced by chondrosarcomas and could have a potential role as autocrine growth stimulators in these neoplasms, results suggest that the TGF-beta1 gene at chromosome 19q13.1 may be a candidate susceptibility locus for hypertension in Japanese women, Signaling transduction induced by PF4 in erythroleukemia cells was compared with that induced by TGFB1, which is also a potent inhibitor of HEL growth., TGF beta1 expression and angiogenesis in colorectal cancer tissue., TGF-beta 1 induces apoptosis of primary cultured bronchiolar epithelial cells via caspase-3 activation and down-regulation of cyclin-dependent kinase inhibitor p21., Direct stimulation of tubular epithelial cells with TGF-beta(1)/epithelial growth factor results in an increased migratory capacity across bovine tubular basement membranes preparations., present in diabetic foot ulcers, induced in cicatricial pemphigoid, TGF-beta polymorphisms do not have a strong influence on disease onset or clinical progression in sarcoidosis and tuberculosis, although this polymorphism might have an effect on the immune response in a tuberculosis host, p38 MAP kinase regulation of AP-2 binding in TGF-beta1-stimulated chondrogenesis of human trabecular bone-derived cells, TGF-beta1-stimulated osteoblasts require intracellular calcium signaling for enhanced alpha5 integrin expression, No significant variations in the distribution of the genotypes and haplotypes were observed between Alzheimer patients and controls., distribution of intracellular and extracellular expression in human testis and its association with spermatogenesis, HTLV-1 tax represses Smad-mediated TGF-beta signaling., Transforming growth factor-beta-induced transcription of the Alzheimer beta-amyloid precursor protein gene involves interaction between the CTCF-complex and Smads, Angiotensin II induces its promoter activation; has a similarity to hyperglycemia., TGFbeta1 regulates BGN expression and is part of a cell growth regulation pathway, TGF-beta1 gene are not suitable genetic markers of MVP in Taiwan Chinese., TGF-beta1 has a role in activation of endothelial cell apoptosis along with TNF-alpha, Data suggest that SMAD3 interactions with the positive regulators NKX2.1 and HNF-3 underlie the molecular basis for TGF-beta-induced repression of surfactant protein B gene transcription., Results demonstrate that TGF-beta1 stimulates matrix metalloproteinase-9 production and promoter activity in a process that depends of the activation of the Ras-ERK1,2 MAP kinase pathway., Differential effects of FGF4, EGF and TGFB1 on functional development of stromal layers (progenitor cell-outputs) in acute myeloid leukemia, TGFB1 has a smaller role than TGFB3 in endometrial differentiation, activation of TGF-beta1/Smad2 signaling is associated with airway remodeling in asthma, TGFbeta1 regulates GM-CSF induced human myelopoiesis, This protein increases E. coli K1 adherence, invasion, and transcytosis in cultured human brain microvascular endothelial cells., transforming growth factor-beta1 is closely related to the invasion and metastasis of colorectal cancer, Decrease of TGF-beta1 plasma levels and increase of nitric oxide synthase activity in leukocytes as potential biomarkers of Alzheimer's disease, TGF-beta1 inhibition of COL2A1 gene transcription in articular chondrocytes is mediated by an increase of the Sp3/Sp1 ratio and by the repression of Sp1 transactivating effects on that gene, TGF-beta1 regulates human enhancer of filamentation-1 expression, TGF-beta mediated G1 arrest requires P27, Kip1, in cancer cell line, In this study, the expression of Smad4 protein appeared to be correlated with the depth of invasion of esophageal SCC, Resistance to transforming growth factor-beta occurs in the presence of normal Smad activation., 1,25(OH)(2)D(3) treatment of Caco-2 cells results in activation of latent TGF-beta 1 facilitated by the enhanced expression of IGF-II receptor, TGFbeta1 stimulated epithelial-mesenchymal transition of SiHa cells, indicating a positive role in the invasive transition of tumors., relationship to intragraft messenger RNA expression of angiotensinogen and to chronic allograft nephropathy in kidney transplant patients, expression of mRNA for IL-4, IL-5, TGF-beta1, IFN-gamma in patients with cicatricial pemphigoid, TGF-beta 1 in combination with IL-13 increases production of eotaxin-1 in airway fibroblasts from asthmatic and normal subjects., A role for TGF-beta in estrogen and retinoid mediated regulation of the nuclear receptor coactivator AIB1 in MCF-7 breast cancer cells., MKK3 activation is required for subsequent p38alpha and p38delta MAPK activation and collagen stimulation by TGF-beta1, TGF-beta1 is a potent inducer of HO-1 and examined the signaling pathway by which TGF-beta1 regulates HO-1 expression in human lung epithelial cells, induces TGFBI in pancratic cancer cell lines and in pancreatic cancer cells in vivo, Substance P up-regulates the TGF-beta 1 mRNA expression of human dermal fibroblasts in vitro, Levels of phosphorylated Smad2/3 are sensors of the interplay between effects of retinoic acid and TGF-beta or vitamin D3 on monocytic and granulocytic differentiation of HL-60 cells., HTLV1 Tax inhibits TGF-beta1 signaling by reducing the Smad3 DNA binding activity, children with active celiac disease have an altered expression of TGF-beta1 and TGF-beta3 in the small intestine, involvement of Furin gene regulation in the maturation of TGFB1 in differentiating megakaryoblastic cells, TGF-beta(1) might regulate the TARC-related inflammatory processes, which may be important for understanding the pathogenesis of allergic diseases., the molecular mechanisms by which autocrine TGF-beta may selectively contribute to tumor cell motility, Polymorphism in this gene affects immunosuppression in stable kidney transplantation., Codon 10 and codon 25 polymorphism affect gene expression and protein synthesis in stable renal allograft recipients., The role of TGF-beta1 and -beta3 in generating a high TIFP was investigated in xenografted experimental anaplastic thyroid carcinoma (ATC) derived from the human ATC cell line, decreased ability to modulate Th1 response in mucosal leishmaniasis, LMP1 inhibits transforming growth factor-beta 1-mediated induction of MAPK/p21 in Epstein-barr virus infected gastric epithelial cell line GT38, Urinary TGF-beta1 and Amadori albumin were elevated in patients with micro- or macroalbuminuria, Localization of TGF-beta(1) mRNA and protein within tubular epithelial cells, with its increased urinary excretion in nephrotic syndrome, suggest the activation of these cells by filtered protein towards increased TGF-beta(1) production., Data demonstrate that Egr-1, AP1 and Smad are part components of the transforming growth factor beta signal transduction pathway that regulates PPAR gamma expression., may contribute to a reduction of proteolytic activity of human gingival fibroblasts in Cyclosporin A-induced gingival overgrowth which favors the accumulation of extracellular matrix, Exposure of human skin diploid fibroblasts to repeated subcytotoxic doses of ultraviolet-B induces its mRNA overexpression, cigarette smoke-induced oxidative stress and TGF-beta(1) modulate expression of the cell cycle inhibitor p21(waf1/cip1), TGF beta 1 signaling and stimulation of osteoadherin in human pulpal fibroblasts and in early secretory and mature odontoblasts., investigated TGF-beta 1, -beta 2, and -beta 3 latency-associated peptides (LAP)expression in sound and carious human teeth, An examination of quantitative gene expression of this protein in the renal artery wall of chronically rejected human renal allografts., mutations in the signal peptide and latency-associated peptide of TGF-beta1 facilitate TGF-beta1 signaling, Genetic variation at the TGF-beta 1 locus is unlikely to confer significant susceptibility to advanced diabetic nephropathy in patients with type 1 diabetes mellitus., results indicate that cervical cancer cells affect the amount and the composition of the intratumoral stroma and the tumor infiltrate by the production and secretion of transforming growth factor-beta(1), transforming growth factor-beta (TGF-beta) signaling is modulated by endogenous sphingolipid mediators, TGF-beta signal transduction and mesangial cell fibrogenesis. Review., the role of Smad proteins in TGF-beta1-mediated fibroblast-myofibroblast terminal differentiation, downregulated Notch2 expression in cultured human dental slices, TGF-beta1 up-regulates expression of integrins and fibronectin, an effect that is associated with autophosphorylation/activation of focal adhesion kinase., Data show that high glucose alters endothelial cell growth, apoptosis, and cell cycle progression, but not apoptosis and endoreduplication, via a transforming growth factor-beta1 autocrine pathway., fibroblast transcriptional programming in response to TGF-beta1 during development, oncogenesis, tissue repair, and fibrosis, transforming growth factor-beta1 was produced in follicular and luteal phases and stimulated cell proliferation mainly in leiomyoma cells, Results suggest that the destabilization of interferon-gamma (IFN-gamma) mRNA induced by transforming growth factor beta leads to the inhibition of antiviral activity and IFN-gamma production in interleukin-18-stimulated LNK5E6 cells, TGF-beta1 signaling potentiates renal tubular epithelial cell apoptosis by a Smad-independent, p38 MAP kinase-dependent mechanism., Transforming growth factor beta1 (TGF-beta1) plays a central role in wound healing and fibrosis and has been implicated in the pathogenesis of keloid disease and hypertrophic scar., Association of transforming growth factor beta-1 single nucleotide polymorphisms with radiation-induced damage to normal tissues in breast cancer patients., Transforming growth factor beta overexpression is associated with advanced stage gallbladder cancer, TGFB1 treatment of ECV304 cells increased bacterial cell adhesion., TGF-beta1 may contribute to eosinophil and mast cell migrations into nasal polyp tissue., by inhibition of cell migration, increased expression of TGF-beta1 after ischemia delays recovery of proximal tubule structure and function., Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome., TGF-beta1 expression in peritoneal fibroblasts was increased by hypoxia and/or TGF-beta1 stimulation, favoring adhesion development., TGF-beta1 inhibited IFN-gamma and TNF-alpha-induced TARC production in HaCaT cells via Smad2/3. Modulation of TGF-beta/Smad signaling pathway may be beneficial for treatment of atopic dermatitis., TGF-beta1 potentiates Abeta production in astrocytes and may enhance the formation of plaques burden in the brain of Alzheimer's disease patients, Hip, lumbar spine and wrist fracture incidence for women with the TGF-beta1 Leu/Leu genotype was not significantly different when compared with that for women with Leu/Pro genotype., Pro10 allele in the TGF-beta(1) gene pathway might contribute to prevalent diseases such as obesity and type 2 diabetes mellitus., expressed in acute respiratory distress syndrome, The C(-1348)-T and T(29)-C polymorphisms were distributed similarly in osteoporotic patients and normal controls, however, the rare genotypes were associated with higher bone mass at the hip., G2 arrest induced by TGF beta1 in the Rb-negative hepatoma cell line and compared with G1 arrest in the Rb-positive hepatoma cell line, Our results suggest that TGF-beta T869C (Leu 10Pro) gene polymorphism is associated with diabetic nephropathy in Chinese., TGFb has a role in stimulating Sp1, which results in up-and down-regulation of UGDH, Distortion of autocrine transforming growth factor beta signal accelerates malignant potential by enhancing cell growth as well as PAI-1 and VEGF production in human hepatocellular carcinoma cells., THP-1 monocytic cells cultured in the presence of TGFB1 show decreased phagocytosis toward IgG-coated sheep red blood cells, suppressed expression of common gamma-subunit and signaling properties of FcgammaR, and downregulated MCP-1 production., Transforming growth factor-beta1 produced by ovarian cancer cell line HRA stimulates attachment and invasion through an up-regulation of plasminogen activator inhibitor type-1 in human peritoneal mesothelial cells., may be one of the most important factors in the regulation of the [gingival inflammatory} infiltrate and in the production of tissue repair with a stimulation of fibroblasts and endothelial cells, role in genetic susceptibility of tuberculosis, TGF-beta 1 increases glucocorticoid binding and signaling in inflammatory cells through a Smad 2/3- and AP-1-mediated process., TGFbeta transcriptionally regulates tristetraprolin in human T cells, Glucocorticoids significantly inhibited TGF-beta1 and TGF-beta2 production and reduced expression of the up-regulated TGF-beta1 and TGF-beta2 mRNA induced by exogenous TGF-beta1, -beta2, or -beta3, TGF-beta1-controlled reduction in SDF-1 expression influences bone marrow cell migration and adhesion, which could affect the motility of cells trafficking the bone marrow., Certain specific cytokine genotypes for TGF-beta1, IL-10, and TNF-alpha are not associated with chronic allograft dysfunction. Normal kidney with low TGF-beta1 genotype at codon 10 had lower TGF-beta1 mRNA., TGF-beta1 may be involved in activation of cdk inhibitor p21WAF1 in gastric adenocarcinoma, promoter may have a small effect on the modulation of the inflammatory process during periodontitis, An increased concentration of wild-type GFAT in mesangial cells is enhanced both TGF-beta1 and fibronectin., This is a novel mechanism of TGF-beta 1 inhibition requiring early G(1) induction and stabilization of p21 protein, which binds to and inhibits cyclin E-CDK2 and cyclin A-CDK2 kinase activity rather than direct modulation of cyclin or CDK protein levels., transforming growth factor-beta signaling is regulated by protein inhibitor of activated STAT, PIASy through Smad3, TGF-beta and IGF-II in the bone microenvironment coordinately amplify IGF-I bioavailability through controlled IGFBP-4 proteolysis, which may be a means to promote bone formation., TGF-beta1 upregulates VDUP1, gene expression profiling in epidermolysis bullosa acquisita, Transforming growth factor-[beta]1 polymorphism is not a factor associated with the occurrence of ossification of the posterior longitudinal ligament [OPLL], but related to the area of the ossified lesion. The "C" allele might be a risk factor, the R218C mutation increases TGFbeta1 bioactivity and enhances osteoclast formation in vitro, a time-dependent release of TGFB and PDGF-AB occurred at neutral and alkaline pH, but not pH5, 15 min and 12h after platelet activation, suggesting relevance to wound healing, Serum levels of both bFGF and TGF-beta1 were found to be significantly higher in chronic lymphocytic leukemia., TGFbeta1 polymorphisms do not play a role in the pathogenesis of systemic sclerosis, but they may be a risk factor for genetic susceptibility to pulmonary fibrosis., TGF-beta1-mediated collagen I accumulation is associated with cytoskeletal rearrangement and Rho-GTPase signaling, These data provide evidence for a functional role for integrin alphavbeta8-mediated activation of transforming growth factor-beta in control of human airway epithelial proliferation in vivo., the antiproliferative effect of TGFbeta is decreased by epidermal growth factor in primary human ovarian cancer cells, After acceleration of regenerative response by HGF, subsequent elevation of TGF-beta1 synergistically controls graft size, regulating uncontrolled proliferation of hepatocytes., TGF-beta1-mediated MAP kinase activation controls WNT-7A gene expression and Wnt-mediated signaling through the intracellular beta-catenin-TCF pathway, Neutralizing anti-TGF-beta1 antibody reversed the inhibition of keratinocyte proliferation., low serum leptin, high serum TGF-beta1 and sOb-R levels, and elevated urine leptin concentrations were observed at the onset of minimal change nephrotic syndrome, the ligand-binding domain of GR, but not the DNA-binding domain or the N-terminal activation domain, is required for GR-mediated transrepression of TGF-beta transactivation, All three TGF-beta isoforms have fibrogenic effects on renal cells. TGF-beta2 and TGF-beta3 effects may be partially mediated by TGF-beta1. Blockade of all isoforms together may yield best therapeutic effect in reducing renal fibrosis., Polymorphisms in TGF-beta1 influence risk for hemodialysis access failure. By inducing synthesis of extracellular matrix proteins, overproduction of TGF-beta1 may accelerate intimal hyperplasia, resulting in fistula stenosis and subsequent access failure., transforming growth factor-beta signaling is inhibited by interferon gamma through direct interaction of YB-1 with Smad3, Four novel polymorphisms in TGFB1 are found not associated with spinal bone mineral density in postmenopausal Korean women., TGF beta1 regulates cell cycle proteins and may induce multiple independent signals to check the proliferative potential of human trophoblastic cells and allow their functional differentiation, a new function of TGF-beta1, which is to promote undifferentiated keratinocyte amplification, Genetic and immunohistochemical studies convincingly suggest a link between TGF-beta 1 and the pathogenesis of autoimmune-associated congenital heart block., TGF-beta1 in cartilage is active in periods of skeletal immaturity and is closely associated with increases in chondrocyte UDPGD activity, signaling in keratinocytes is regulated by glycosylphosphatidylinositol-anchored proteins, Plasma TGF-beta1 levels of thrombocytopenic neonates were significantly lower than those of healthy nonthrombocytopenic neonates but did not differ significantly from nonthrombocytopenic neonates with similar perinatal risk factors for thrombocytopenia., Biological dressing effect of cultured epidermal sheets(CESs) is mediated by EGF family, TGF-beta, and VEGF., In the confluent state, TGF-beta1 and TGF-beta2 stimulated the cells to progress to the S-phase of the cell cycle through platelet-derived growth factor-B (PDGF-B) chain production and protein kinase C., sumoylation of Smad4 was strongly enhanced by TGF-beta-induced activation of the p38 MAP kinase pathway but not the Smad pathway, DACH1 bound to endogenous NCoR and Smad4 in cultured cells; Smad4 was required for DACH1 repression of TGF-beta induction of Smad signaling, Found in renal artery of kidney allografts in chronic rejection., a signal transduction cascade of the TGF-beta/Smad signaling pathway, which is activated in the GEC, appears to be involved in the development of focal segmental glomerulosclerosis, there is a TGF-beta1-activated pro-survival/anti-apoptotic signaling pathway in mesenchymal cells/fibroblasts, Mortal and early immortal stages of both cell lineages displayed growth reduction upon exposure to TGF-beta1., ANG II-induced activation of latent TGF-beta1 in human mesangial cells operates via TSP-1, effect of restoring the growth-inhibitory autocrine circuit in epithelial cancer cells that have retained sensitivity to growth inhibition by TGF-beta1 but which produce and secrete insufficient amounts of endogenous peptide, TGF-beta 1 also activates the mitochondrial pathway showing Bid-mediated loss of mitochondrial membrane potential and subsequent cytochrome c release associated with the activations of caspase-9 and the effector caspases., TGF-beta1 is a negative regulator of NF-kappaB activation in the gut, transforming growth factor-beta 1 gene polymorphism is associated with prostate cancer and benign prostatic hyperplasia, The physical appearance of endometriotic implants and the severity of dysmenorrhea appear to be related to the expression of TGFbeta1 in nerve fibers., findings suggest that the coexpression of c-erbB-2 oncogene protein, epidermal growth factor receptor, and TGF-beta1 in pancreatic ductal adenocarcinoma is related to the histopathological grades and clinical stages of tumors, The worse the cancer cell differentiation and lymph node metastasis, the more over-expression of TGF-beta1., TGF-beta acts as an endogenous, radiation-inducible radioresistance factor in esophageal carcinoma cells, There was increased TGF-beta 1 mRNA expression in the stenotic tissue after clinical ureteropelvic junction obstruction. Alteration of TGF-beta 1 expression may be involved in the pathogenesis of congenital hydronephrosis., TGF-beta and Smad3 mediate beta-hydroxybutyrate-induced cell cycle-dependent growth inhibition in the human proximal tubule (HK-2 cell), Glucose induces an early increase in TGF-beta 1 transcription via activation of p38MAP kinase. In addition, glucose causes a late increase in PDGF-dependent TGF-beta 1 translation by enhancing cellular sensitivity to PDGF., transforming growth factor-beta regulates the Kindler syndrome protein, transcription upregulated directly by Hepatitis C virus core protein in parenchymal cells and suggests a new paradigm for exacerbation of liver fibrosis by HCV infection, Stimulation of vascular endothelial cells with TGF-beta1 induced marked increase in the expression level of HAS2 mRNA and protein., The above results indicate that PKB-Ser-473 and FAK-Tyr phosphorylation stimulated by TGF-beta1 are both dependent on cell adhesion., The combination of high AT and TGF-beta1 producing polymorphisms is associated with advanced hepatic fibrosis in obese patients with non-alcoholic fatty liver disease, findings established the existence of a novel alternative/complementary pathway by which furin increases tumor cell invasion through an amplification/activation loop between MMP-2 and TGFbeta, Treatment of premyelinating aggregate rat brain cultures with recombinant human TGF-beta 1 results in greater accumulation of myelin basic proteins and FGF-2 and PDGF-AA production., Endogenous TGF-beta plays an important role in the cell cycle arrest of c-kit(high) but not c-kit(low/-) cells in CD34+ CD38- cells., results indicated that TGF-beta1-promoted cell adhesion and TGF-beta1-induced epithelial-to-mesenchymal transformation might be both responsible for TGF-beta1-enhanced cell migration, ability of TGF-beta1 to polarize the differentiation of HPCs induced by IL-3 towards LC development, although IL-3 DCs were unable to form BGs partly because of their poor ability to induce Langerin, role in urokinase up-regulation and promotion of ovarian tumor invasion, TGF-beta regulates IL-4 signaling by targeting NF-kappaB signaling, Review. the role of the anti-inflammatory cytokine transforming growth factor beta in atherosclerosis, expression values for TGF 1 and its receptors I, II, and III were twice as high in the group of patients with a diagnosis of high-grade lymphomas as in the group of patients diagnosed with low-grade lymphomas, Suppressor function of human CD4+CD25high regulatory T cells involves a TGF-beta 1-dependent mechanism., TGF-beta is transcriptionally repressed by c-Ski protein in esophageal squamous cell carcinoma, TGF-beta(1) expression in bronchial mucosa may play a role in bronchial subepithelial fibrosis in eosinophilic bronchitis (EB) patients., TGF-beta signaling is disturbed by Smad7-Smurf-mediated negative regulation in fibrotic disorders, We demonstrated that TGFbeta1 repressed FGF10 promoter activity in primary prostatic tissue, via a region of the promoter containing an Sp1 binding site., TGF-beta has a role in radiation-induced fibrosis and is inhibited by halofuginone, examination of inactivation in thyroid nodules by gene expression analysis, TGFbeta, which is abundant in the bone matrix, directly induce mononuclear phagocyte osteoclast precursors to differentiate into osteoclastic cells capable of lacunar resorption, inhibitory signals induced by IL-3 on breast cancer blood vessel assembly were abrogated by the addition of the neutralizing TGF beta antibody, a new molecular mechanism linking with up-regulated TGF-beta1 promoter activity, a novel mechanism of control of TGF-beta action that may be important in fibrosis, HIV-infected lymphocytes indirectly contribute to lymph node remodeling by secretion of TGF beta 1, which increases fibronectin synthesis by fibroblasts., TGF-beta function is abrogated in vivo by SCF(beta-TrCP1) which decreases Smad4 stability, TGF-beta1 is highly expressed in hairy cells and is directly involved in the pathogenesis of bone marrow reticulin fibrosis in hairy cell leukemia, Jab1/CSN5 as an adapter that targets Smad7 for degradation, thus releasing Smad7-mediated suppression of TGF-beta1 signaling., TGFbeta and Wnt ligands have roles in regulating differentiation and cell fate determination [review], a novel, functional binding element in the proximal region of the TN-C promoter mediating responsiveness to TGF-beta involving Smad3/4, Sp1, Ets1, and CBP/p300, TGF-beta functions as a classic embryonic inducer, initiating a cascade that is controlled by other factors in the cellular environment., polymorphisms in TGF-beta1 have a role in development of breast cancer, HIV infection resulted in a significant increase of plasma TGF-beta(1) concentration compared to healthy individuals (11.4 +/- 6.8 vs. 6.1 +/- 1.5 ng/mL, p < 0.01), suggestive of an immunosuppressive role in HIV pathogenesis., High expression of TGF-beta1 may be involved in the incidence of lung cancer., MMP3, MMP9, and TGFbeta1 are important for the modulation, composition, and maintenance of the ECM in oral squamous cell carcinoma, Recombinant human TGF-beta 1 signals through multiple murine intracellular signaling pathways to inhibit T cell expansion., In prostatectomy patients, preoperative plasma levels of TGF-beta(1) and IL-6sR are associated with metastases to regional lymph nodes and disease progression., overexpression of HER2 in nontumorigenic mammary epithelial is permissive for the ability of TGF-beta to induce cell motility and Rac1 activity and HER2 and TGF-beta signaling cooperate in the induction of cellular events associated with tumor progression, coiled coil-induced dimerization of the ectodomains stabilize their interaction with TGF-beta as compared with the monomeric ectodomains, certain pathological condition-induced TGFbeta1 overexpression in the skin may synergize with or induce molecules required for the development of Th1 inflammatory skin disorders, TGF-beta 1 polymorphisms at positions -509, +869 (codon 10), and +915 (codon 25) do not play a dominant role in alcoholic chronic pancreatitis, sustained activation of p44/42 MAPK perhaps forms the stimulatory signal induced by low TGF-beta1, whereas activation of p38 forms the inhibitory pathway, TGF-beta1 inhibited the growth of most nontransformed cells. Many cancer cell lines were insensitive to this effect. It induced Smad2 phosphorylation in the majority of cell lines, including those resistant to TGF-beta1-mediated cell-cycle arrest., The K allele of KLK1 promoter and TT genotype of TGF-beta1 may be a genetic KLK1 -130 GN and -128 G-C, and the susceptibility factor contributing to progressive renal deterioration in Taiwanese primary vesicoureteric reflux children., TGF-beta and IL-2 trigger a cytokine-dependent self-perpetuating loop to sustain specific T regulatory cell suppressive activity., blood TGF-beta 1 has a role in preventing progression of esophageal neoplasms, combined production of the immunosuppressants IL-10 and TGF-beta, as well as coexpression of TGF-beta RI and RII (required for cellular response to TGF-beta), may act to down-modulate host anti-Mycobacterium tuberculosis immunity, increase of serum immunoglobulin A in newborns during 1 month of life was well correlated with levels of both transforming growth factor-beta1 and transforming growth factor-beta2, TGF-beta1 may play a key role in liver fibrogenesis., dual signaling pathways involving TGF-beta1, an antiapoptotic pathway mediated by the Smad pathway involving p21, and an apoptosis-permissive pathway mediated in part by p38 MAPK., transforming growth factor-beta-mediated responses through p38alpha and Smad signaling pathways require MSK1, Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis, TGFB1 polymorphism may play a role in advanced stage prostate cancer., Endothelial cell vessel assembly requires TGFB1 signaling transduction pathways., TGF-beta1 mRNA and protein are specifically upregulated in carcinoma-associated fibroblasts, some SNP's are associated with chronic obstructive pulmonary disease, identified as being responsible for downregulation of gap junctional intercellular communication via an increase in the level of reactive oxygen species in stromal fibroblasts, AGE- (advanced glycation end-products)& TGF-beta-mediated signals, by converging on STAT5 activation & p21waf expression, may regulate mesangial cell growth., upregulation of MUC4 by TGF-beta is restricted to well-differentiated pancreatic cancer cells, and point out a novel mechanism for TGF-beta as a key molecule in targeting MUC4 overexpression in pancreatic adenocarcinomas., results indicate a new interaction partner for the alpha(v)beta(3) integrin, the TGFbetaIIR, in which TGFbeta1-induced responses are potentiated in the presence alpha(v)beta(3) ligands, incubation of NK cells and LAK cells with TGF-beta1 resulted in dramatic reduction of surface NKG2D expression associated with impaired NK cytotoxicity, TGF-beta1 gene polymorphisms are specifically associated with heavy proteinuria and mesangial cell proliferation in Japanese patients with IgA nephropathy, although they do not confer susceptibility to this disease., TGFbeta1, 2 and 3 mRNA expression correlates with the developmental growth of the prostate, and potentially effect smooth muscle distribution., TGF-beta has a role in activation of the MAP kinase signaling system resulting in cell cycle progression in tumor cell lines, The G/C substitution at codon 25 was associated with an increased risk for prevalent vascular disease, new onset cardiac morbidity, and cardiac mortality in HD patients, and may be a genetic susceptibility factor for the development of atherosclerosis., Reactive oxygen species mediate TGF-beta1-induced TIMP-3 gene expression, The genetic differences in codons 25 and 263 suggest that TGF-beta1 could play an important role in occurrence of clefts of the lip, alveolus, and palate, however, functional experiments will be required to confirm the mechanisms of disturbed development., Patients with RHD have a lower frequency of TGF-beta1 C-509T CC genotype and a higher frequency of T869C T allele, which supports a role for these polymorphisms in determining the risk/protection of RHD in Taiwan Chinese patients, acyl-coenzyme A, part of an autocrine/paracrine system involved in the regulation of COX-2 expression in the distal pulmonary circulation, Patients with Systemic lupus erythematosus (SLE) had lower serum levels of TGF-beta1 compared with controls, cyclic AMP inhibits umbilical vein endothelial cell angiogenesis indued by TGFB1., TGF-beta1 overexpression at early stages of head and neck squamous cell carcinoma formation provides a tumor promoting microenvironment., TGF-beta1 and integrin stimuli interact prior to Smad2 and 3 phosphorylation in the cytoplasm of chondrocytic cells and regulates the expression of ECM components in chondrocytes., TGF-beta1-induced pericellular collagenolysis is controlled by MT1-MMP activity, which is regulated by ERK 1/2- and p38 MAPK-modulated TIMP-2 expression, Differentiated macrophages play protective role in pathophysiology of gout. Macrophage TGFbeta1 is mediator of paracrine suppression during resolution phase of inflammation., TGF-beta and ET-1 have roles in mechanical force generation in keratinocyte-fibroblast co-cultures, and GM-CSF induces myofibroblasts acting indirectly, autocrine TGF-beta regulates the cell cycle through a pathway different from exogenous TGF-beta in the sense that p21 is a more sensitive effector of the TGF-beta signaling pathway, heightened ERK and PKCdelta activity in high ambient glucose conditions interact with the Smad pathway, leading to enhanced responsiveness to TGF-beta1 and increased extracellular matrix production in mesangial cells., TGF-beta1 may play an important role in the process of plaque stabilization., Our results indicate that TGF-beta(1) gene Arg(25)-->Pro, TNF alpha gene G-308A and IL-6 gene G-174C polymorphisms are not risk factors or markers of progression in focal segmental glomerulosclerosis, Polymorphic in pancreatitis., HCV viral proteins interact with the TGF-beta signaling mediator Smad3 and differentially impair TGF-beta/Smad3-mediated transactivation and growth inhibition., involvement of TGFbeta1 in the development of endothelial cell response to high glucose in terms of chondriotin sulfate accumulation and cell binding to hyaluronic acid., Data show that the WSXW motif binds the VLAL sequence on both latency-associated peptide and mature TGF-beta, and these interactions are critical for thrombospondin-1-mediated activation of the TGF-beta latent complex., critical roles for interleukin-4 and IL-12 in regulating 4-1BB effects on TGF-beta1-mediated suppression, An association between T29 -C polymorphisms of TGF-beta1 gene and BMD, bone turnover and fragility fractures were demonstrated in postmenopausal southern Chinese women., C-509T and G-800A polymorphisms are not associated separately or in haplotype combinations with early implant failure, TGF-beta 1 significantly downregulated CFTR mRNA and cAMP-dependent current in nasal polyp cultures; data suggests that chronic inflammation in nasal polyposis downregulates CFTR gene and protein expression, Patients with renal cell carcinoma have enhanced expression of TGFB1 mRNA and protein in tumor samples and increased serum levels of TGFB1., chronic active Epstein-Barr virus infection T-cells are activated to transcribe IFN gamma, IL-10, and TGF beta excessively, and the latter two genes are expressed preferentially in the EBV-infected subsets, TGF-beta(1) stimulation of human biglycan mRNA expression relies on increased transcription of the biglycan gene, and is mediated by members of the Sp1 family of transcription factors., FcepsilonRI+ on dendritic cells is finely modified by the TGF-beta1 concentration in the microenvironment and could be of primary relevance in the context of atopic diseases., TGF-beta 1-stimulated CTGF expression is mediated by mechanisms involving ERK and JNK pathways and is downregulated by IL-4 and IL-13 through modulation of Smad and ERK signals., may play an important role in the metastatic proclivity of selected tumor types, The TGFB1 T+869C (Leu10Pro) gene polymorphism is associated with multiple sclerosis susceptibility, especially in males., disruption of signaling by interfering with the recruitment of CREB-binding protein into transcription initiation complexes on TGF-beta-responsive elements, TGF-beta is not involved in early phase growth inhibition by 1alpha,25(OH)(2)D(3), VEGF attenuates TGF-beta action in the human endothelial cell, specifically at the level of transcription of PAI-1 gene and Smad2/3 phosphorylation, Bikunin neither decreased expression of TGF-beta receptors (TbetaRI and TbetaRII) in cancer cells nor altered the specific binding of 125I TGF-beta1 to the cells., inhibition of transforming growth factor-beta activation is required for stimulation of vascular smooth muscle cell proliferation and migration by apolipoprotein(a), Extracellular matrix ECM production can be stimulated independently by hypoxia and TGF beta 1., key dependence of the fibrogenic actions of CTGF on TGF-beta in kidney, Blocking TGF-beta may have important hemodynamic effects that are relevant to treating diabetic nephropathy., TGF-beta1 gene polymorphisms is associated with renal allograft rejection, Genetic variation of the TGF-beta1 gene may affect longevity; haplotype combination (G -800/C -509/C 869/C 915) was notably lower in centenarians than in younger individuals, TNF-alpha stimulation of PTC in the presence of BMP-7 failed to increase monocyte-dependent TGF-beta1 stimulatio, No significant differences were observed in the genotype distribution of the three TGF-beta1 polymorphisms between patients and controls., TGF-beta1 polymorphisms are associated with end-stage renal disease, particularly in patients with associated clinical cardiovascular disease, and could be useful as genetic markers of chronic renal disease and higher cardiovascular risk., induced by R5 HIV-1 infection of fetal thymic organ culture (FOTC) which in turn induced CCR5 expression, H-ras and TGF-beta signal pathways interact with each other in MCF10A human breast cells may provide an insight into molecular mechanisms for contribution of TGF-beta to a malignant progression of breast cancer in collaboration with activated H-ras, caspase-3 is crucial for the differentiation of bone marrow stromal stem cells by influencing TGF-beta/Smad2 pathway and cell cycle progression, negative effect of TGFbeta1 on ADAMTS-1, -5, -9, and -15 coupled with increases in their inhibitor, TIMP-3 may aid the accumulation of versican in the stromal compartment of the prostate in BPH and prostate cancer, the leiomyoma and myometrial smooth muscle cells molecular environment is targeted by the autocrine/paracrine action of TGF-beta, TGF-beta1 affects both proliferation and apoptosis of gastric cancer cells through the regulation of p15 and p21, and induces transient expression of Smad 7 as a negative feedback modulation of TGF-beta1 signal., internalization is important for transforming growth factor beta1-induced Smad2 association with Smad anchor for receptor activation (SARA) and Smad2-dependent signaling in human mesangial cells, TGF-beta1 blocks the NF-kappaB activation and cytokine release that is stimulated by ligands for TLRs 2, 4, and 5, Abeta1-42 may play an important role in the negative regulation of TGF-beta1-induced MMP-2 production via Smad7 expression, Daxx suppresses Smad4-mediated transcriptional activity by direct interaction with the sumoylated Smad4 and has a role in regulating transforming growth factor beta signaling, TGFbeta1 can induce increased expression of both SPARC and type I collagen. Specific inhibition of SPARC led to decreased expression of type I collagen and attenuated the profibrotic effect of TGFbeta1 in cultured normal human fibroblasts., TGFbeta produced by keratinocytes contribute to selectively downregulate CD1d expression on intraepidermal-resident Langerhans cells, Langerhans cells may resist activation by human papillomavirus-like particles in normal epithelium abundant in TGF-beta, but not in situations in which TGF-beta concentrations are reduced, Adrenomedullin can attenuate TGF-beta1-mediated renal tubulointerstitial extracellular matrix turnover via an antagonistic mechanism of inhibitory Smad6 in TGF-beta1-elicited signaling., A role for TGF-beta1 in UVB-induced premature senescence in skin fibroblasts., Ca(2+) entry mode operation of the Na(+)/Ca(2+) exchanger is required for des-Arg(10)-kallidin- and TGF-beta1-stimulated fibrogenesis and participates in the maintenance of the myofibroblast phenotype, Inflammatory cytokine different from TGF-beta1 may differently orchestrate cell fate in AAT and smoking-related emphysema types., the level of Smad6s can alter the level of TGF-beta and the subsequent induction of PAI-1 via a FoxD1 transcription site, Hepatic progenitor cells are resistant to the proliferative and apoptotic effects of TGFb1, Compared to normal population, the frequencies of genotypes producing high TGF-beta1 protein were higher in IgAN patients, and patients with genotypes showed a poor renal survival rate., augmented in gingival crevicular fluid of smokers with chronic periodontitis, TGFbeta1/Smad3 suppresses BRCA1-dependent DNA repair in response to a DNA damaging agent, Continuous secretion of TGFB1 by cell-mediated gene therapy maintains chondrocyte redifferentiation., implicated in the deposition of excessive extracellular matrix in the vessel wall, contributing to atheromatic plaque, the genetic polymorphism in codon 10 of the TGF-beta1 gene may play a role in hepatocellular carcinoma development in patients with chronic hepatitis B infection., results support the notion that human papillomavirus type 18 E6 protein renders cells less sensitive to the cytostatic effect of TGF-beta by lowering the intracellular amount of TIP-2/GIPC, examined the signal transduction pathways by which TGF-beta induces hyaluronan synthesis in normal orbital fibroblasts, orbital fibroblasts from patients with Graves' ophthalmopathy, and abdominal fibroblasts, a specific cross-talk between TGF-beta1 and fibronectin-binding integrin signal pathways leads to the activation of c-Src/Rac1/actin-organization, leading to changes in cell cycle regulator levels in hepatoma cells, it is reported in this study that TGF-beta induces binding of HTLV virions and expression of glucose transporter type 1 in primary CD4(+) T lymphocytes that remain quiescent, Through adenoviral gene transfer technology, we describe a novel mouse model of colitis and implicate TGF-beta1 in the pathogenesis of obstructive intestinal fibrosis., Smad7-mediated inhibition of NF-kappaB activation via the induction of IkBalpha may be the central mechanism by which latent TGF-beta prevents renal inflammation., TGF-beta1 polymorphism may determine the progression of joint distraction in rheumatoid arthritis patients., TGF-beta signaling suppresses nuclear export of Smad4 by chromosome region maintenance 1 and targets Smad4 into the nucleus; mutations in Smad4 that affect its interaction with Smad2 or Smad3 impair nuclear accumulation of Smad4 in response to TGF-beta, TGF-beta1 polymorphisms are associated with fibrosis progression in Caucasians chronically infected with hepatitis C., Functionally relevant genetic variants of the TGF-beta1 gene are not associated with nonalcoholic chronic pancreatitis., TGF-beta 1 polymorphism may modify individual susceptibility to breast cancer in premenopausal Korean women, Smad7 acts to functionally inactivate RB and de-repress E2F without blocking the activation of TbetaRI and the nuclear translocation of Smad2/3, allowing TGF-beta1 to exert effects in a cancer cell that is resistant to TGF-beta1-mediated growth inhibition, Transforming growth factors beta (TGF-betas) are multifunctional cytokines that modulate cell growth, differentiation and apoptosis, Cerebral glucose utilization is reduced preferentially in transgenic mice overexpressing TGF-beta 1 and showing Alzheimer's disease-like cerebrovascular abnormalities., Glucose-mediated transforming growth factor-beta1 release in human mesothelial cells is endothelin independent., Results demonstrate that transforming growth factor-beta induces endothelin-1 expression by a functional cooperation between Smads and activator protein-1 through activation of the Smad signaling pathway., TGF-beta 1 suppresses not only the acquisition but also expression of effector function on memory CD8 T cells and tumor-infiltrating lymphocytes reactive against melanoma and can hinder the therapeutic benefits of cancer vaccination and immunotherapy., TGF-beta/Smad3 signaling is required for hypoxia-mediated inhibition of adipocyte differentiation in marrow stromal cells, TGF-beta1 concentration may predict the development of kidney graft fibrosis., TGFbeta1 transfected smooth muscle cells conditional medium produced significantly more endothelial colonies (P<0.05). The adhesion force between endothelial progenitor cells and smooth muscle cells in TGFbeta1 group was higher than control., The activation of c-Src by TGF-beta1 is EGFR dependent and is required for full Akt phosphorylation and cell survival, Findings suggest that the TGF-beta1 gene polymorphism does not predispose to the development of refractory anemia, but may affect disease progression., Recombinant human TGF-beta 1 inhibits priming phase IFN-gamma expression in part through inhibition of Stat4 expression, but inhibits Th1 effector phase IFN-gamma expression through inhibition of T-bet expression., TGF-beta1 gene therapy blocks islet destructive autoimmunity, facilitates islet regeneration, and cures diabetes in diabetic NOD mice., Tsc-22 modulates the TGF-beta-dependant signaling pathway, Might play significant role in physiology of trabecular meshwork and contribute to pathological changes of this tissue in certain forms of glaucoma., Human TGF-beta2 but not human TGF-beta1, or -beta3 promotes cardiac myocyte differentiation from mouse ES cells., Insensitivity to TGF-beta in some prostate cancer cells is due to promoter methylation in TbetaRs, TGF-beta1 inhibits hepatocyte growth factor (HGF/SF) levels in external auditory canal cholesteatoma (EACC) epithelial cells, TGF-beta 1 could make a difference regarding prognosis and prediction in breast cancer patients if it were evaluated in relation to the status of the tumor markers estrogen receptor and epidermal growth factor receptor 2 (HER-2), Blood levels increased in acute viral hepatatitis, shich may be connected with the degree of hepatocyte damage., expression and the activity of TGF beta1 signalling components in B cell lymphoma cell lines (e.g. HT 58 cells) and in isolated human peripheral mononuclear cells from healthy individual's and B-CLL patient's blood, Repression of fgf8 might be directly or indirectly involved in this transcriptional control by TGF-beta., in a model system, TGF beta-1 released from activated platelets contributes to the hemostatic imbalance at the sinusoidal endothelium in patients with hepatic VOD by increase of endothelial cell PAI-1 production and TF expression., The high expressions of TGF-beta1 and TGFbR1 play important roles in spontaneous abortion., results of this study indicate that IFN-gamma may contribute to the development of type 2 diabetes, based on a combination of molecular and immunological observations, Significant differences between chronic kidney failure(CKF) and controls in allele frequencies of two SNPs, Leu10Pro and C-509T and in haplotype distributions, indicating association with susceptibility to CKF., TGF-beta1 low-production genotypes were associated with an increased odds of disease relapse in breast cancer, AIP4 restricts transforming growth factor-beta signaling through a ubiquitination-independent mechanism, HHT is an angiogenic disorder characterized by an over-expression of VEGF, TGF-beta1 and ALK1, No differnce in haplotype distribution were detected for whites and African Americans for preterm birth and SGA., In this cohort of young healthy Caucasian females, the T allele at position -509 of TGF beta-1 is associated with greater bone mass as measured by calcaneal ultrasound., TFG-beta is an inducer of gremlin expression in diabetic nephropathy., These results demonstrate for a functional role for TGF-beta ligands in regulation of mammalian Mixl1, identify FoxH1 as an essential co-activator, and implicate Nodal as the embryonic regulator of Mixl1 in mesendoderm morphogenesis., TGFbeta-1 is a major immunomodulatory component of poststorage leukocyte-depleted blood transfusions., Hypoxia-induced tumor cell tolerance to glucose starvation is caused by hypoxia-induced TGF-beta1 through AMP-activated protein kinase-alpha activation and the Akt/ARK5 system., An inverse relationship is shown for the first time in the ratio between ICAM1-expressing lymphocytes and transforming growth factor (TGF)-beta 1 serum concentrations during the clinical stages of acute rheumatic fever., TGF-beta1 enhances mineralization on implant materials of osteoblast cultures from elderly human subjects, results show that TGFbeta could induce tumoral progression in bladder carcinoma using a paracrine loop, confirming a role for the microenvironment, Transforming growth factor-beta1 (TGF-beta1) plays a critical role in promoting extracellular matrix (ECM) deposition and fibrosis., the signaling network involving Smad-dependent TGFbeta, PKCdelta, and integrin alpha2beta1/alpha3beta1, regulates cell spreading, motility, and invasion of the SNU16mAd gastric carcinoma cell variant, May function as an effect modifier of APOE4 risk; plays a role in Alzheimer's disease pathogenesis, TGF-beta1 expression is related to tumor growth and metastasis in pancreatic adenocarcioma, TGF-beta1/bFGF and ET-1 have different roles in graft fibrosis in heart failure patients, TGF-beta and pro-inflammatory cytokines regulate MEL4B3, a novel mRNA induced in skin tumors, TGF-beta1 dose-dependently repressed Sftpb promoter activity in vitro, and a novel TGF-beta-responsive region in the Sftpb promoter was identified., Folic acid deficiency could result in reduction of TGF-beta1 protein levels and might contribute to formation of defects in the skull bone as observed in mengingocele patients, TGF-beta 1 is involved in the suppressive activity of Leishmania guyanensis-stimulated CD4+ CD25+ T cells from healthy controls, During tuberculosis, predisposition of CD4 T-cell subsets to apoptosis may involve both low expression of Bcl-2 and excessive expression of transforming growth factor (TGF)-beta., TGF-beta-induced cell cycle arrest and migration, but not epithelial-mesenchymal transition, are abolished after silencing of Smad4., Significantly higher expression of TGFbeta1 and bFGF, although lower expression of core protein on the concave side, suggesting possible etiological factor or secondary change in development of adolescent idiopathic scoliosis., Association of endometriosis with TGF-B 1-509 gene polymorphism exists. T homozygote and T allele for TGF-B1 are associated with higher susceptibility to endometriosis., Up-regulated expression of TNC in nasal polyp tissues is related to eosinophil-derived TGF-beta1., Smad4, but not Smad2, mediates TGF-beta1-induced MMP-2 expression in invasive extravillous trophoblasts, TGFB1 regulates a wide variety of biological responses through transcriptional regulation of target genes. Disruption of ELF-1 results in the loss of the Smad4 activation and, therefore, a disruption of the TGF-beta pathway., Data show that leukotriene C4 stimulates airway epithelial cells through a p38 mitogen-activated protein kinase activation mechanism to produce transforming growth factor beta1, which results in fibroblast proliferation., Data show that endothelial cells express CD222 and CD87 in a membrane complex and demonstrate that the association of these two receptors is essential for the release of active TGF-beta., A C to T base change in TGFbeta1 SNP C-509T is associated with a higher risk of allergy., Angiogenesis in keloids is promoted by endogenous TGF-beta1 and VEGF., This study indicates an autocrine mechanism to maintain homeostasis in vivo for fibroblasts and other cell types, which produce TGF-beta1 to limit the fibrogenic response to TGF-beta1 and Bleomycin., This work presents in vivo and in vitro evidences of activation of TGF-beta1 expression by androgen and AR, and implicates the modulation of hepatocarcinogenesis by AR through the regulation of TGF-beta1 expression., Genetic variation in the 5' end of TGFbeta1 or a nearby upstream region modifies disease severity in cystic fibrosis., TGF-beta signaling transduction in the kidney can be revealed by gene expression data mining., TGF-beta 1 may promote endometrial tissue repair through the inhibition of the proliferation, expansion, and migration of endometrial stromal cells, and through stimulation of contraction of the collagen gel matrix by these cells., The TGFbeta(1)-induced destabilisation of E-cadherin-mediated cell-cell adhesion involves phosphorylation of beta-catenin, which is regulated by E-cadherin adhesion complex-associated PI3-kinase and PTEN., The reciprocal modulating effects of FGF2 and TGFbeta1 on each other's receptors make the GM-490 cell line a new model for investigating the relationship between these growth factors and their receptors in autocrine loops., stimulates transcriptional activity of LTBP-3 promoter, PU.1 and Id2 modulate lineage options of langerhans cell precursors, downstream of TGF-beta1., TGFbeta stimulates transformation in the proepicardium., STRAP acts as an intermediate signaling molecule linking between the phosphatidylinositol 3-kinase/PDK1 and the TGF-beta signaling pathways, Distinct roles for Smad2 and Smad3 in TGFbeta1-induced CTGF expression and markers of EMT in human PTECs are reported., The release of TGF-beta1 in morbid obesity was primarily by the nonfat cells of human adipose tissue because release by adipocytes was less than 10% of that by the nonfat cells of adipose tissue., integrin-mediated TGFbeta activation is likely to play important roles in tumor growth and metastasis [review], Transforming growth factor-beta stimulates epithelial-mesenchymal transformation and smooth muscle differentiation of epicardial cells., Hyaline cartilage regeneration was studied using chondrocytes and TGFB1-producing chondrocytes., TGF-beta is involved in the physiological loss of gastric epithelial cells by activating apoptosis mediated by Smad7, Bim, and caspase-9, Increased glomerular expression of thrombospondin-1 (THBS1), transforming growth factor beta 1 (TGFB1), and connective tissue growth factor (CTGF), occurs from the earliest stage of diabetic nephropathy., role in persistent fungal pneumonia whereby it contributes to the local control of infection by enhancing macrophage antifungal efficacy through increased lysozyme secretion, A compartison of TGFB/Smad signaling was made between normal dermal fibroblasts and fibroblasts derived from central and peripheral areas of keloid lesions., Laminin-5 and TGF-beta1 cooperatively induce epithelial to mesenchymal transition in hepatocellular carcinoma, Review summarizes the role of TGF-beta as a potent ligand that regulates carcinoma, initiation, progression and metastasis through a broad and complex spectrum of interdependent interactions., Tenascin-C and TGF-beta1 were expressed in the majority of high-grade gliomas. Induction of Tenascin-C by TGF-beta1 may be a possibe mechanism for invasion of high-grade gliomas., Review of recent studies shows that insulin-like growth factor (IGF)-I signals cross-talk at multiple levels with various components of the TGF-beta signal pathway which, depending on context, may function either as tumor suppressor or as tumor promoter., Recent evidence in this review support a role for TGF-beta in the induction of tolerance and the control of autoimmune inflammation in the gut., TGF-beta1 in post-transurethral bladder tumor resection urine alters the expression of multiple genes in human transitional cell carcinoma in vitro, Decreased activity of TGFbeta in patients with acute coronary syndromes is at least partly due altered transcriptional activity of genes encoding TGFbeta., Review discusses genetic alterations and epigenetic modifications that occur in the different components of the TGF-beta superfamily signaling pathways in human tumors, and summarizes their correlation with clinical outcome., TGFbeta and interleukin-6 might play pivotal but opposing roles in the host tumor interaction, Contraction induced by different factors, therefore, may be differentially associated with apoptosis, which may be related to the persistence or resolution of the fibroblasts that accumulate following injury., TGF-beta1 production and fibrosis require IL-13 signaling through the IL-13alpha2 receptor, involvement of TGFbeta1 through the Smad proteins in fibrotic diseases, signalling pathways induced by ET-1 and TGF-beta1 leading to augmented collagen I production by fibroblasts converge on a similar signalling pathway. Thereby, long-time stimulation by ET-1 resulted in a changed ET-receptor subtype ratio, Our correlative study suggests a role of TGF-beta-1 in early interstitial fibrotic changes in acutely rejected renal allografts, and we hypothesize that endothelin-1 and myofibroblasts pathways may play an important role in this process., transforming growth factor-beta1 overexpression and alteration in E-cadherin/beta-catenin complexes in bladder urothelium might play a crucial role in urinary bladder carcinogenesis in humans exposed to long-term low-dose ionizing radiation, TGFB1 possesses a highly polymorphic, extensive regulatory region that likely impacts the pathogenesis of numerous TGF-beta1 related diseases., The overall effects of TGF-beta1 in the kidney seem to be negative that increased expression of TGF-beta1 promotes interstitial fibrosis and vasculopathy associated with chronic allograft nephropathy., TGF-beta1 mRNA levels distinguish chronic allograft nephropathy patients from long-term transplant patients with stable renal function and varied levels of proteinuria., TGF-beta1 may function as a regulatory factor in fetal allograft survival during pregnancy., TGF-beta1 gene polymorphism may affect the disease progression in patients with myelodysplastic syndrome, TGF-beta1 acts on adjacent stromal cells to turn on Smad signalling that could lead to stromal decidualization., HCV NS5A modulates TGF-beta signaling through interaction with TbetaR-I, the PI3-K pathway negatively regulates TGF-beta/Smad signaling in neuroblastoma cells, These observations, together with the finding that CILP protein binds and inhibits TGF-beta1, suggest that CILP and TGF-beta1 may form a functional feedback loop that controls chondrocyte metabolism., TGF-beta1 increases in vitro airway wound repair via MMP-2 upregulation in respiratory epithelial wound repair., SRC-1 and GRIP-1, act as both corepressors of the glucocorticoid repression of PAI-1 gene transcription, and coactivators of TGFbeta-induced activation of the PAI-1 promoter., Enteric glial cell effects on Caco-2 cell density are significantly reduced by a neutralizing TGF-beta antibody., While high levels of TGF-beta appeared to be associated with protection against periportal fibrosis during chronic schistosomiasis mansoni, the strength of the association was low., Adrenaline can increase the production of bFGF and decrease production of TGF-beta1 and I procollagen in human normal dermal and hypertrophic scar fibroblasts cultured in vitro., TGF-beta1 production was stimulated in Group A Streptococcus infected primary human tonsil fibroblasts., Administration of losartan, but not amlodipine, to hypertensive patients improves structural abnormalities and prevents the production of CTGF and TGF-beta in small arteries., GDF15exerts cardioprotective effects whereas TGF-ss1 does the opposite., positive (transforming growth factor beta1) and negative (cigarette smoking extract) regulators appear to influence the USF-E-box interaction and affect P4Halpha(I) expression, Elevated glucose concentrations increased TSP-1 synthesis, which was associated with reduced cell proliferation, increased TGF-beta1 bioactivity, and stimulation of FN synthesis, We propose that one of the mechanisms involved in TIMP-1 downregulation may be through TGF-signaling in chronic immune activation. These studies show a novel extracellular regulatory loop in astrocyte-TIMP-1 regulation., TGF-beta1 polymorphisms and their haplotypes is associated with adenocarcinoma and small cell carcinoma of the lung, TGF-beta is involved in neointimal formation in renal transplants during chronic rejection., Blood levels are usesful in the prognosis of antiviral treatment of chronic hepatitis C., TGF-beta1 signaling regulates IL-8 expression in prostate cancer cells and may contribute to the overexpression of IL-8 in human prostate cancer, new mode of cooperation between the TGF-beta and Wnt signaling pathways suggests a potentially important role for this distinct signaling pathway in the control of self-renewal and differentiation of a specific type of MSCs, Deviation in CD105/TGF-beta ligand complexes suggest that angiogenesis mediated by this complex is not a feature of pancreatitis., We conclude that cell matrix factors act cooperatively with cytokines to induce the expression of the components of the NADPH-oxidase in monocytic progenitor cells., The present review summarises the actual knowledge on the pathogenesis of hepatic fibrogenesis, the role of TGF-beta and its signalling pathways in promoting the fibrogenic response, and the therapeutic modalities., Our results suggest that TGF-beta signalling and subsequent expression of fibrogenesis related proteins in Dupuytren's disease is abrogated by NAC thus providing a basis for a therapeutic strategy in Dupuytren's disease and fibroproliferative disorders., The increase in the PDGF/TGF-beta ratio during uterine leiomyoma growth seems be important in tumour biology, In conclusion, EC death induced by high shear stress and VEGFR blockade leads to the production of factors, in particular TGF-beta1, that activate VSMC proliferation., studies demonstrate a novel role for IL-1alpha in mediating a proliferative response to TGF-beta signaling, analysis of inhibin and transforming growth factor beta-binding sites on betaglycan, tumor-derived TGFbeta-1 induces immunosuppression within sentinel lymph nodes (SLNs) before the movement of tumor cells into the SLNs, thereby facilitating metastasis within those nodes, c-Fos binding at the TGFbeta1 promoter proximal AP-1 site in human colon carcinoma cells is required for TGFbeta1 production by the tumor cells., PDGF-BB and TGF-beta1 binding to intact alpha2M is specific, involving a defined region of the alpha2M subunit, In systemic lupus erythematosus, TGF-beta1 activation was linked with increased lymphocyte apoptosis, irreversible organ damage, and disease duration., TGF-beta1 decreased ADAMTS-1 mRNA and protein levels in decidual stromal cell cultures in a concentration- and time-dependent manner., upregulated expression of alphavbeta5 contributes to autocrine TGF-beta signaling in localized scleroderma fibroblasts, Our findings collectively suggest that non-classical secretion of Prx-I is induced by TGF-beta1, which is constitutively activated by furin in A549 cells., While a weak subepithelial proliferation occurs in stent-related stenoses, the dominant factor in late stages of untreated tracheal stenoses seems to be the high-level expression of TGF-beta1 and the deposition of extracellular matrix., Neutrophil derived elastase (NE) upregulates TGF-beta1 gene expression and release via My88/IRAK/NF-kappaB pathway, possibly through activation of TLR4, and shed light on a potential role of neutrophils in the pathogenesis of asthma., analysis of how the TGFbeta signal is disrupted in cancer [review], EGR-1 is induced by transforming growth factor-beta and mediates stimulation of collagen gene expression, An association between the TGF-beta1 genetic profile and the development of PVR (proliferative vitreoretinopathy) was detected in this study., 'large' molecular weight molecules, the most important of which appears to be TGFbeta(1), make a significant contribution to immunosuppression by human seminal plasma, Gene expression alterations indicate a sophisticated regulation of counteracting tumor necrosis factor-alpha and transforming growth factor-beta cytokine expression in peripheral blood leukocytes after acute myocardial infarction, immunomodulatory pathways in the kidney are specifically dependent on TGF-beta(1), proliferation of Th1 clones are inhibited by TGF-beta1, whereas Th2 cells are not; the sensitivity of individual Th1 clones to TGF-beta1 is linked to the level of activation achieved in culture, Allele T at codon 10 (risk ratio, 6.7; P = 0.02) and an episode of acute rejection before protocol biopsy (risk ratio, 6.2; P = 0.01) were independent predictors of subclinical rejection., levels of TGFbeta-1 and TGFbeta R-2 were increased in the intimal matrices, smooth muscle cells, and macrophages, as well as in endothelial cells of atherosclerotic aorta, Expression is significantly associated with Peyronie's disease and may be a direct cause for its development., role of TGF-beta signaling in positively regulating host defense response by tightly controlling the expression level of TLR2 during bacterial infections, TGFbeta suppresses TERT by Smad3 interactions with c-Myc and the hTERT gene, TGF-beta1 plays a role in the progression of IgA nephropathy., Interleukin (IL)-13 and transforming growth factor-beta1 (TGF-beta(1)) are frequently coexpressed in these responses and are believed to play important roles in the pathogenesis of Th2-induced pathologies., CC homozygote may be at a higher risk of developing high myopia. Varied expression of this gene may contribute to the genetic predisposition to high myopia in Chinese Taiwanese., TGFbeta acts on hypoxia-inducible transcription factor-1alpha (HIF-1alpha) accumulation and activity by increasing HIF-1alpha protein stability, TGF-beta1 regulates COX-2 expression in human mesangial cells through the activation of ERK1/2, p38 MAPK, and PI3K, VEGF, FGF2, TGFB1, EGF and IGF1 have roles in the development of both prostate cancer and benign prostatic hyperplasia, These findings suggest that the TGF-beta1 (+915C) polymorphic allele might be associated with chronic periodontitis in the Turkish population., a novel mutation was found to result in the inhibition of translocation of Smad3 protein to the nucleus and a reduction in the activity of Smad3 during TGF-beta-induced transcriptional activation, In summary, results suggest that an autocrine loop of TGF-beta confers resistance to apoptosis after an EMT process in hepatocytes, through the increase in the expression of EGFR ligands., overexpression of VEGF, its receptors flt-1, KDR/flk-1 and TGF-beta interaction may play an important role in the ovarian cancer biology, with potential effects on tumor growth and angiogenesis, These studies demonstrate that induction of fibulin 5 gene expression in lung fibroblasts is mediated via canonical TGF-beta/Smad signaling and requires the PI3-kinase/Akt pathway., in tumor cells becoming resistant to TGF-beta1-mediated growth inhibition, increased induction of the remaining TGF-beta1 pathways by interaction with other antiproliferative molecules, such as 4-hydroxynonenal, could help in inhibiting tumor growth, These results suggest that RACK1 modulates transcription of alpha2(I) collagen by TGF-beta1 through interference with Smad3 binding to the gene promoter., TGFbeta1 is significantly elevated in the cerebrospinal fluid in HIV-1 infected patients., These findings elucidate the function and complex regulation of integrin-mediated activation of TGF-beta within the epithelial-mesenchymal trophic unit (EMTU)., TGFB expression is not affected by hyperhomocysteinaemia either in normal or in high glucose in fibroblasts., These preliminary data suggest that the TGF genetic variability may be important in the risk of vascular related dementia., TGF-beta1 mediates a physiologically relevant regulatory mechanism, selective for memory T cells present in the tumor microenvironment and nonmalignant chronic inflammatory tissues, TGF-beta1 overexpression is associated with advanced stage of esophageal adenocarcinoma and implies a negative impact on survival, High serum TGF-beta1 levels may be associated with an increased risk of death from pancreatic cancer., Transforming growth factor beta1 (TGF) seems to be an important stabilizing factor and prevents plaque rupture through the decrease of matrix metalloproteinases (MMPs)., The expression of TGF-beta1 and E-cadherin are correlated with lymph node metastasis in supraglottic larynx squamous cell carcinoma., Altered expression of several genes is responsible for disrupted TGF-beta signaling in ovarian cancer and may be useful as new and novel therapeutic targets for ovarian cancer., increased toxic interactions by TGF-beta1 plus CYP2E1 can occur by a mechanism involving increased production of intracellular ROS and depletion of GSH, resulting in mitochondrial membrane damage and loss of membrane potential, followed by apoptosis, This study demonstrates a direct interaction of the IGF and TGF-beta systems in human renal carcinoma cells. The observations that IGF-I enhances the TGF-beta signaling and that TGF-beta promotes IGFBP-3 production, TGFB1 T+869C gene polymorphism is involved in the susceptibility to duodenal ulcer., Synthesis of TGFbeta-1 and type I TGFbeta-receptor increases over time in recipients developing chronic allograft nephropathy., analysis of the mechanism through which results showed that Human Papillomavirus-16 E6 and E7 increased TGF-beta1 promoter activity in cervical tumor cells, supernatants from HPV-transformed cell cultures contained IL-10 and TGF- beta1., NPN is a novel member of the SLRP family that may play important roles in kidney development and pathophysiology by functioning as an endogenous inhibitor of TGF-beta signaling, Korean subjects carrying the Leu/Leu and Pro10Leu sequence variants in and around the promoter and exons of TGFB1 are susceptible to both ischemic stroke and vascular dementia., The mRNA expressions of TGFbeta1 in hMSCs increased with the length of cell culture., In proximal tubular epithelial cells, TGF-beta1 autoinduction requires the coordinated action of independently regulated Smad and non-Smad pathways., Study demonstrates elevated TGF-beta1 levels in women with prior history of gestational diabetes mellitus., TGF-beta1 may play a role in the tissue remodeling processes in allergic rhinitis., TGF-beta1 induced morphologic and molecular expression changes suggestive of epithelial-to-mesenchymal transition in a Barrett's adenocarcinoma cell line. These were reversible by BMP7., TGF-beta "cross-links" the HER2/Vav2/Rac1/Pak1/actin/actinin complex at cell lamellipodia, prolonging Rac1 activation and increasing cell survival and metastasis., aberration of the TGF-beta pathway promotes carcinogenesis of oral squamous cell carcinoma, MCP-1 functions as a chemoattractant to stimulate migration of VSMCs and mesenchymal cells toward ECs, signaling is enhanced by dephosphorylation of linker regions of Smad2 and Smad3, The fibrotic action exerted by TGF-beta1 in the lung is mediated by MAPK activation and by an increased synthesis of the profibrogenic cytokines IL-6 and IL-11; all these effects are prevented by corticosteroids via inhibition of MAPK phosphorylation., In cystic fibrosis, both extremes, highest or lowest TGF-beta 1 production, were associated with impaired lung function, TGF-beta1 stimulates the Gene expression profiles of LX-2 cells in the presence and the absence of rhDecorin., TGF-beta1 activates IL-6 production, and the functional interaction between TGF-beta1 and IL-6 contributes to intrahepatic cholan-giocarcinoma (ICC) cell growth by TGF-beta1., Results reveal potential new signaling pathways and several new genes affected by TGFbeta in epithelial cell differentiation., SHP is a novel co-regulator of Smad3 that regulates TGF-beta signaling, uterine natural killer cell responses to microbial pathogens in the endometrium are regulated by the amount of biologically active TGF-beta present within the human endometrium, TGFbeta1 inhibited the appearance of cell death-inducing DFF-like effector A (CIDE-A) in 2-D gels with Helix pomatia agglutinin-precipitated proteins, cross-talk between TGF-beta1 and Vascular Endothelial Growth Factor(VEGF) signaling converts VEGF/flk-1-activated p38(MAPK) into a proapoptotic signal, Polymorphisms of TNF-alpha, IFN-gamma, TGF-beta1, IL-10 and IL-6 do not appear to influence the onset of broncholitis obliterans syndrome or graft survival in recipients., Variants in genes for TGF-beta1 (Leu10>Pro and Arg25>Pro)are not associated with low BMD in postmenopausal Czech Caucasian females., These results suggest a central role for KLF11 in TGFbeta-induced c-myc repression and antiproliferation., This review emphasizes the unique ability of TGF-beta to direct CD4+ T-cell lineage commitment to both proinflammatory T helper 17 (Th17) cells and anti-inflammatory T regulatory cells., This preliminary study is the first to suggest that the TGF-beta1 signal sequence (29T-->C) and IL-6 promoter (-597G-->A)|(-572G-->C) transitions are predictive for the time to onset of aseptic instability after total hip arthroplasty, different patterns of infiltration in desmoid and fibroma tumours are due to changes in extracellular matrix (ECM) components and cell-ECM interactions which can be ascribed to altered TGFbeta(1) mRNA expression and TGFbeta(1) activity, mutations of the amino-acid residues, D55 and E142 of TbetaR-II, resulted in loss of TGF-beta binding and downstream signaling activity, TGFbeta expression is induced by rhinovirus infection in respiratory epithelial cells, The mRNA levels of TGF-beta1 were significantly produced by the megakaryocytes may be associated with the etiology of bone marrow fibrosis in AMM., Tsg functions as an agonist synergizing with TGF-beta to inhibit T-cell activation., The variant alleles of the promoter polymorphisms, TGFB1 C-509T and TGFBR2 G-875A, were associated with a significantly decreased risk of gastric cancer., An inhibition of brain pericyte-derived TGF-beta1 contributes to the occurrence of CsA-induced dysfunction of the blood-brain barrier., These results also indicate that the CSF level assay of TGF-beta1, TbetaR-II and LRG is useful for the diagnosis of patients with INPH, and TGF-beta1, TbetaR-II and LRG may be involved in the pathogenesis of the disease., We found a highly significant association between TGF-beta polymorphisms and calcineurin inhibitors induced end-stage renal failure after heart transplantation., Epac1 inhibits TGFbeta-dependent regulation of cell migration and adhesion through TbetaRI, Plasma concentrations of MMP-2, MMP-9, TIMP-1, and TGF-beta1 significantly differed between the various histopathological types of primary glomerulonephritis., TGF-beta1 (codon 25) single-nucleotide polymorphisms are associated with susceptibility to chronic periodontitis in the population studied., Disruption of the TGF-beta 1-Smad signaling pathway may lead to the resistance of TGF-beta 1 growth-inhibitory effect on oral squamous cell carcinoma., The expression of collagen type II and TGF-beta1, bFGF in adolescent idiopathic scoliosis was similar to congenital scoliosis., calcineurin-induced reduction of Treg or TGF-beta expression predisposes nontransplanted tissue to inflammation, but indicate that combined immunosuppression hampers Treg development in the intestine., findings show that RTK/Ras/MAPK (mitogen-activated protein kinase) activity induces p53 N-terminal phosphorylation, enabling the interaction of p53 with the TGF-beta-activated Smads; this mechanism promotes TGF-beta cytostasis in human cells, fibrillin-1, which forms extracellular microfibrils, can regulate the bioavailability of transforming growth factor (TGF) beta1, a powerful cytokine that modulates cell survival and phenotype, These results suggest that the +869C allele, responsible for a Leu-->Pro substitution in the signal peptide sequence of the TGF-beta1 protein, may have a predisposing role in the development of colorectal cancer., These results suggest that TGFbeta Smad3-dependent signalling is perturbed in Barrett's carcinogenesis, resulting in failure of growth-arrest., TGF-beta induces p65 acetylation to enhance bacteria-induced NF-kappaB activation., Both vitreous and TGF-beta signals increased HO-1 expression in retinal pigment epithelial cells via reactive oxygen species., Our study suggests a role of transforming growth factor beta-1 in interstitial fibrotic changes in renal AA and AL amyloidosis., results provide evidence that, at low concentrations, TGF-beta-1 promotes matrix metalloproteinase dependent branching tubulogenesis by mammary epithelial cells in vitro, and suggest that it plays a similar role during mammary gland development in vivo, TGF-beta signaling regulates gut epithelial gene expression by targeting GATA4., High TGFbeta is associated with glioma, up-regulates nerve growth factor in human dental pulp cells, The results indicate that Langerhans cells depend on soluble factors for the maintenance of the differentiated state within epidermis and that TGF-beta1 is a major one of such factors, the direct interaction of NM23-H1 and STRAP is important for the regulation of TGF-beta-dependent biological activity as well as NM23-H1 activity, common variants in TGFB1 gene do not strongly influence genetic susceptibility to diabetic nephropathy in an Irish Caucasian population, TGF-beta1, together with Notch signaling, functions to arrest epithelial growth., PDK1 negatively regulates TGF-beta-mediated signaling in a PDK1 kinase-dependent manner via a direct physical interaction with Smad proteins, and Smad proteins can act as potential positive regulators of PDK1, Transforming growth factor-beta1 may be a factor in inducing the expression of c-fms in cervical cancer cells., This largest study to date of genetic variation in TGFB1 and asthma and atopy adds to increasing evidence for a role in these disorders., The polymorphism of TGF-beta1 may at least partially explain the genetic predisposition to an aggressive course of the disease with the development of terminal stage., No correlation between disease activity and increased salivary TGF-beta 1 concentration is shown in twenty-eight patients with confirmed diagnosis of Crohn's disease., Persons with osteoporosis have an increased oxidative stress that is not accompanied by changes in TGF-beta 1 levels., Early and sustained increases in matrix stiffness occurred in response to rhTGF-ss1, which could be increased by IL-1beta. It stimulated expression of alpha-SMA, collagens I & III, and CTGF., These data suggest that EGF may be an attractive alternative to TGF-beta1 for engineering fibrin-based connective tissue substitutes with adequate strength and minimal tissue contractility., These results suggest that TGFbeta1-induced FN production in HKC cells is p38 MAP kinase dependent and Smad independent. Targeting p38 MAP kinase may be of therapeutic value in renal fibrosis., The positive expression of TGF-beta1mRNA was 78.75% (33 cases), and was positive correlative to the bone metastasis, TNM stages, MVD in prostate cancer., These data suggest autocrine TGF-beta1 antagonizes BMP signaling through modulation of inducible Smad6 and the activity of BMP specific Smad1/5., analysis of cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways, TGFbeta promotes conversion of CD16+ peripheral blood NK cells into CD16- NK cells with similarities to decidual NK cells., TGF-beta1 modified ADP-induced tyrosine phosphorylationof 64-, 80- & 125-kDa proteins depending on incubation time. The modulating effect of TGF-beta1 on platelet aggregation may play a role in pathological states and vascular injury., No association could be found between transforming growth factor-beta1-509 (C/T) promoter gene polymorphism and patients with ulcerative colitis., TGF-beta1 polymorphisms, and their haplotypes are significantly associated with nasopharyngeal carcinoma, Data showed that the frequency of the TGFbeta (G codon 25) allele is 1.00 and no TGFbeta (C codon 25) allele is found., Nox4 influences the pathobiochemistry of asthma by generating reactive oxygen species that promote TGF-beta1-induced proliferation and hypertrophy of human airway smooth muscle, Surface expression of TGF-beta on DCs in association with LAP is one of the mechanisms by which immature DCs limit T cell activation and thus prevent autoimmune responses., TGF-beta (-509)CC genotype may be a protective factor for pneumoconiosis. TGF-beta (+915)GC genotype may be a susceptible factor for pneumoconiosis., findings indicate the Leu10Pro & C-509T polymorphisms may be involved in modulation of expression of TGF-beta1; predisposition to peptic ulcer disease could be linked to particular alleles of this gene, Suppression of hepatitis C virus-specific interferon-gamma-producing peripheral T cells seemed to be primarily mediated by TGF-beta 1, in the setting of HIV coinfection., Real-Time-PCR showed that TGFbeta1 expression is auto-inductive, whereas FGF2 is auto-repressive. FGF2 also induced TGFbeta1 secretion in the absence of increased TGFbeta1 mRNA expression., autocrine TGFbeta signaling can enhance the survival of MCF-7 cells by maintaining the level of active Erk high and the level of active p38 low., WNK1 is a dual modulator of TGFbeta-Smad signaling pathways, The aim of the study was to determine the pattern of immunohistochemical expression of transforming growth factor beta1 (TGFbeta1), metalloproteinase 9 (MMP-9), and Ki-67 in colorectal cancer and adenomatous polyps., Sequence variants of the TGF-beta1 gene were not associated significantly with high myopia., Although ulcerative colitis patients have abnormal amounts of salivary TGF-beta1 and nitric oxide, their disease activity cannot be predicted by these factors, which may indicate their pathophysiologic roles., The aim of this study was to examine the role of TGFbeta in an in vitro model of islet morphogenetic plasticity, transforming growth factor 1beta1-stimulated JC virus multiplication is blocked by MEK1/2 inhibitors, Implication of anticancer therapy-induced TGF-beta as a pro-metastatic signal in tumor cells provides a rationale for the simultaneous use of these therapies in combination with TGF-beta inhibitors., High-producing genotype of TGF-beta may be beneficial and may play a potential role in the resolution of renal inflammation., Interactions of downstream signaling induced by IL-13 in concert with transforming growth factor (TGF)-beta 1 increase Smad activation to regulate tissue inhibitor of metalloproteinase (TIMP)-1 expression in primary airway fibroblasts., we demonstrated that TGFbeta-1 enhanced cytotoxic (proapoptotic) action of doxorubicin towards cultured human lung carcinoma A549 cells., High expression of TGF-beta1 in inflammatory mucosa compared with the low expression in polyps may reflect an important role in the inhibitory mechanisms of nasal polyposis., A novel mutation of TGFB1 in a Chinese family with Camurati-Engelmann disease is reported., SMAD7 antagonizes TGFB1 signaling in the nucleus by interfering with functional Smad-DNA complex formation., TGFbeta1 and TIMP-1 are involved in the course of developing hepatic fibrosis and TIMP-1 may be regulated by TGFbeta1., data suggest that TGFbeta has a direct inhibitory effect on G2 checkpoint kinases, which is regulated at mRNA level, TGF-beta1 may act in an autocrine fashion to induce airway smooth muscle hyperplasia, mediated by its receptor and several kinases including PI3K, ERK, and JNK, whereas p38 MAPK is a negative regulator., These results indicate that impaired competition with p300 is the possible cause of dysfunction of c-Ski/SnoN in scleroderma fibroblasts and that this might contribute to maintenance of the autocrine TGFbeta loop in this disease., The present data suggest that TGF-beta, LMO1, possibly RUNX3, and GSDM form a regulatory pathway for directing the pit cells to apoptosis., The TGFB/SMAD3 signaling pathway is involved in butyrate-mediated vitamin D receptor expression., S100C/A11-mediated pathway is at least partly involved in conferring upon human squamous cell cancers resistant to TGFbeta-induced growth suppression, TGF-beta 1 and cardiotrophin-1 exert differential effects on myofibroblast proliferation and contraction in vitro. A balance of these effects may be important for normal cardiac wound healing., TGF-beta1 has a role as both a disease marker and a therapeutical target for cardiovascular disease [review], negative effect of EBNA1 on the expression of TGFbeta1-responsive betaig-h3 and PAI-1 genes was confirmed at the protein level in EBV-infected carcinoma cells, Substance P modulates fibroblast-mediated epithelial cell restitution in vitro via a TGFB1 dependent mechanism, TGF-beta 1 exhibits an acute pro-oxidant effect in cartilage that is not cytotoxic, suggesting a role in physiological cell signalling, The type of cartilaginous tissue formed under the influence of TGFbeta1 differed in terms of both cell phenotype and gene expression profiles from BMP-2 and -7, endoglin and beta-arrestin2 interact and have roles in regulating transforming growth factor-beta-mediated ERK activation and migration in endothelial cells, Most chronic allograft nephropathy patients have high TGF-beta1 production genotype, which might be a risk factor for CAN after renal transplantation., study found no evidence of association of prostate cancer with five TGFB1 genetic polymorphisms and their haplotypic combinations in the Prostate, Lung, Colorectal, and Ovarian Trial (PLCO), TNF-alpha suppresses TGF-beta1-induced myofibroblast (fibroproliferative) phenotypic genes, for example, alpha-SMA, collagen type 1A, and fibronectin at the mRNA level., PGE(2) has the potential to limit TGF-beta1-induced myofibroblast differentiation via adhesion-dependent, but Smad-independent, pathways, TGF-beta(1) gene polymorphism in codon 10 and 25 is not associated with susceptibility to psoriasis vulgaris, but may be important for the type of the disease., Genetic variants of TGFB1 and TGFBR2 genes may contribute to the risk of developing gastric cancer., The molecular regulation of heme oxygenase-1 by transforming growth factor-beta1 in human renal proximal tubular cells is reported., study shows that the TGFB1-509C>T polymorphism might not be associated with POAG, Treatment with lactate was accompanied by enhanced mRNA expression and release of TGF-beta1, which also shows anti-angiogenic activity in the model., prostate cancer cells have a role in altering endoglin expression and attenuating transforming growth factor-beta signaling in reactive bone marrow stromal cells, These results suggest that T869C polymorphism of the TGFbeta1 gene is involved in the development of autoantibodies and the occurrence of aseptic necrosis in patients with SLE., TGF-beta1 may play a dual role in HBV infection, in the suppression of immune responses against viral infection and in the direct inhibition of viral replication, resulting in minimization of liver damage in patients with chronic hepatitis., ECP stimulates TGF-beta(1)-release by human lung fibroblasts, suggesting a potential mechanism for eosinophils in the fibrotic response., TGF-beta1 influences the susceptibility for otosclerosis, and that the I263 variant is protective against the disease., transforming growth factor-beta signaling in human arterial endothelium during atherosclerosis., The growth factor TGF-beta1a was upregulated in RA synovial fibroblasts, Chronic inflammation associated with hepatitis C virus infection shifts hepatocytic TGF-beta signaling from tumor-suppression to fibrogenesis, accelerating liver fibrosis and increasing risk for hepatocarcinoma., VEGF-A/TGF-beta1 polymorphisms could be genetic markers of the process of urinary tract infection and vesicoureteral reflux., TGF-beta1 may play a role in the pathogenesis of idiopathic male osteoporosis, TGF-beta is a modulator of beta-Catenin levels in tumoral fibroblasts and non-tumoral fibroblasts, despite the oncogenic mutations already present in this gene in tumoral fibroblasts of desmoid tumors., Results describe a contact-dependent mechanism by which mesenchymal stem cells modulate IL-10 and TGF-beta gene expression in T cells., Variants that enhance TGFB1 production may be associated with an increased risk of advanced colorectal adenoma., Adam12 contributes to Tgfb signaling through interaction with the type II receptor., TGF-beta1 can be released from targeted T98G cells and plays a key role as a signaling factor in the radiation induced bystander effect by further inducing free radicals and DNA damage in the nontargeted bystander cells., Inhibition of beta-catenin resulted in increased TGF-beta1-dependent Smad3 phosphorylation and restoration of TGF-beta1 anti-proliferative effects., failure to find any significant association between leukocyte telomere length and 10 single nucleotide polymorphisms in two ageing-related candidate genes, TGFB1 and KLOTHO, MMP-1 produced from melanoma cells may play a role in tumor progression by both degrading matrix proteins and generating active growth factors such as TGF-beta in vivo, No significant SNP or haplotypic associations were observed for TGFbeta1 or hepatocyte growth factor in autism, The content of TGF-beta1 and IL-1beta decreased after the femoral neck injury. In case of TGF-beta1 the difference was statistically significant (p<0.05)., TGF-beta(1) and mechanical stress induce xylosyltransferase I expression in cardiac fibroblasts and have impact for ECM remodeling in the dilated heart., TGF-beta signaling in reactive stroma is angiogenic and tumor promoting and is mediated in part through a TbetaRII/Smad3-dependent upregulation of FGF-2 expression and release., data suggest that ligand release-independent transactivation of EGFR may diversify early TGF-beta signaling and represent a novel pathway leading to TGF-beta-mediated gene expression., transforming growth factor-beta has a role in Smad3-dependent activation of Gli2 and Gli1 expression, TGF-beta reduces interferon-gamma-induced major histocompatibility complex (MHC) class II expression in mesenchymal stromal cells via serum factor and cell density effects on transactivator CIITA expression., An association between the -509C/T polymorphism of the TGF-beta 1 gene and an increased risk of deep infiltrating endometriosis., The mRNA expression of TGF-beta1 in keloid was higher than that in hyperplasic scars and normal skin., Our findings suggest that women who experience eclampsia/pre-eclampsia with severe maternal and/or fetal complications are more likely to have a genetic predisposition to produce high levels of TGF-beta 1 as defined by polymorphisms at codon 10., These results suggest that IL-10, TNF-alpha and TGF-beta1 gene polymorphisms may affect host susceptibility to lung cancer and the outcome of the patients., Exposure of normal human melanocytes to a tumor promoting phorbol ester reverses growth suppression by TGFB1., TGF-beta and TC21 have roles in tumorigenesis, a novel role for the plasminogen activation system in the regulation of fibroblast apoptosis and a potential role of TGF-beta1/PAI-1 in promoting (myo)fibroblast survival in chronic fibrotic disorders., Higher levels of total TGF-beta1 in tumour tissue at surgery may be indicative of distant metastases, and low levels of active TGF-beta1 in plasma may indicate a risk of developing secondary metastases., Smad7 overexpression in cultured hepatocytes abrogated TGF-beta-dependent and intrinsic CTGF expression., hTERT and extremely low concentrations of TGF-beta1 (2 pg/mL) synergistically activate ERK 1/2 in fibroblasts by a mechanism that is independent of the autocrine TGF-beta1 lo, Our data allow us to consider TGF-beta1 and alpha-SMA as key molecules related to placental villous tree phenotypic changes responsible for increased impedance to blood flow observable in fetal growth restriction pre-eclamptic placentae., the role of TGF beta 1 in high glucose-induced MIP-3 alpha expression, The overexpression of TGF-beta 1 and TGF-beta 1 mRNA could be useful markers for early diagnosis and predicting prognosis of HCC., autocrine production of TGF-beta1 upregulates the expression of Hic-5, which is essential for perpetuating the decreased proliferation seen in pathogenic myofibroblast, Children with transforming growth factor, beta 1 (TGF-beta1) -509TT genotype are at higher risk of asthma occurrence if they live near a freeway or were exposed to tobacco smoke in utero., that genetic variants in transforming growth factor beta 1 may modulate the risk of esophageal squamous cell carcinoma., The renal injury of CC genotype in TGF-beta1 is more serious than that of TC genotype and of TT genotype. The serum level of TGF-beta 1 can indicate the severity of the renal injury and the protective effect on kidney with valsartan., Unlike postnatal fibroblasts, fetal fibroblasts phosphorylated extracellular signal-regulated kinases in response to TGF-beta1. These altered responses may contribute to the transition between regeneration and scar formation seen during development., TGFB1 genotypes are associated with erectile dysfunction and late rectal bleeding in radiotherapy for prostate cancer. Identifying these genotypes may predict which men are likely to suffer from poor quality of life after radiotherapy for prostate cancer., Data suggest that polymorphonuclear leukocytes decrease dendritic cell allostimulatory ability via production of elastase leading to a switch of immature DCs into TGF-beta1-secreting cells., lower TGF-beta1 expression is associated with colon carcinoma, Snail1 is involved in renal tubular EMT and TGF-beta1 regulates Snail1 at the transcription and protein degradation levels, Polymorphisms in two key anti-inflammatory cytokines, IL-10 and TGF-beta, are associated with susceptibility to EBV-associated posttransplant lymphoproliferative disorder., In this review, transforming growth factor (TGF)-beta is a key cytokine that initiates and terminates tissue repair associated with peritoneal membrane failure during chronic peritoneal dialysis., Individuals with the transforming growth factor-beta1 -509CC and 869TT genotype may have increased susceptibility to vesicoureteral reflux, The TNFalpha-308A/TGFbeta1 25C genotype may be one component of genetic susceptibility to SLE in Colombian population., hTERT appears to be efficiently regulated by EPO and TGFbeta in an opposite way in erythropoietic cells, arguing for a role of telomerase in red blood cell production, The secretion of TGF-beta1 increased and the synthesis of PGE2 decreased from BRS-3-activated BEC, which were correlated with the proliferation and collagen synthesis of HLF., EBNA1 apparently disables TGF-beta signaling, which subsequently decreases transcription of the PTPRK tumor suppressor, Over one fourth of women with cervical insufficiency have a family history of cervical insufficiency and the COL1A1 intron 1SP1 and TGF-beta Arg-25-Pro polymorphisms are associated with the condition., TGF-beta1-induced Sporothrix schenckii adhesion to endothelial monolayers results from the increased exposure of the subendothelial extracellular matrix and this event may contribute to transendothelial migration., R124C and R555W TGFBI mutations cause lattice and granular type I corneal dystrophies in the studied families., The -509C and codon 10T haplotypes are significantly associated with disease severity indicators in both chronic beryllium disease and sarcoidosis., The expression of TGF-beta1 was reduced in carcinoma tissues compared with para-carcinoma tissues., Raloxifene treatment reduces bone turnover markers, parathyroid hormone and induces vitamin D in postmenopausal women. Serum levels of IL-6 and TGF-beta1 in the patient group after treatment, decreased to levels lower than those in the control group., Polymorphisms in the promoter of TGFB1 are not associated with large increases in breast cancer risk overall among Caucasian women.Alleles associated with increased TGFB1 levels may reduce the risk of estrogen receptorpositive breast tumors., Long-term increases of transgenic TGF-beta 1 play a role in modulating cerebrovascular tone by dampening endothelin-1-mediated activation of the p38 MAP kinase/heat shock protein-27 signaling pathway., TGF-beta(1) might be considered as a predictor of pleural thickening in pleural tuberculosis.There is a correlation between pleural fluid TGF-beta(1) levels before treatment and the degree of pleural thickening., Mutant p53 attenuates TGF-beta1 signaling. This was exhibited by a reduction in SMAD2/3 phosphorylation and an inhibition of both the formation of SMAD2/SMAD4 complexes and the translocation of SMAD4 to the cell nucleus., Gastrointestinal carcinoid tumor fibrosis is a CTGF/TGFbeta1-mediated stellate cell-driven fibrotic response., TGF-beta may modulate the expression of chloride channel protein CLC-2 and CLC-3 in chronic rhinosinusitis without nasal polyps., PCAF-dependent acetylation of lysine 380 abrogates repressor function of Fli1 with respect to collagen expression; TGFb-dependent acetylation of Fli1 may represent the principal mechanism for TGFb-induced dissociation of Fli1 from the collagen promoter, Conversion from calcineurin inhibitors to sirolimus treratment in heart allograft dysfunction presented a significant decrease in TGF-beta urine levels. representing a decreas in allograft dysfunction., These results suggest that TGF-beta1 may be one of the early markers involved in the inflammatory mechanisms underlying the pathogenesis of AD., Review is an impartial and exhaustive compilation of reported papers regarding the contemporary debate over expression of TGFbeta1 in asthmatics and its essential role in airway remodeling., altered transforming growth factor-beta signaling contributes to tumor progression and metastasis as well as development of fibrosis [review], TGF-beta1 promoter gene single nucleotide polymorphisms are not associated with disease susceptibility or progression in Japanese patients with primary biliary cirrhosis, These data reveal a novel function for CTGF in the regulation of epithelial tissue repair beyond its established role in fibrosis, and further highlight the complexity of TGFbeta regulation of epithelial cell function., a novel tumorigenic role of Id-1 through reorganization of actin cytoskeleton and disassembly of cell-cell adhesion in response to TGF-beta1 in human prostate epithelial cells, TGFbeta1 represses CYP7A1 gene transcription in human hepatocytes by a mechanism involving Smad3-dependent inhibition of HNF4alpha and histone deacetylase remodeling of CYP7A1 chromatin., the TGF-beta-inducing protein of H. pylori might mediate the immune response and contribute to the pathogenesis of H. pylori infection, These findings indicated that both the NF-kappaB and IRF-1 sites are required for the repression of promoter activity of IL-12 p40 by TGF-beta., Autocrine TGF-beta1 exists in NPC patients, which is correlated to the local relapse and survival., the up-regulation of TCF11/MafG binding could be suppressed by overexpression of the TGF-beta inhibitor Smad7, and a small interfering RNA to TCF11 blocked the suppression of iNOS by TGF-beta., TGFbeta1 acts directly epidermal Langerhans cells through an autocrine/paracrine loop, and it is required for cell development and/or survival., local and transient TGF-beta1 overexpression induces homogenous, prolonged, and progressive pleural fibrosis, In primary human tubular epithelial cells (HUTEC) under TGF beta 1 stimulus, 977 genes were found differentially expressed., production of TGF-beta1 within the BM microenvironment of chronic idiopathic neutropenia patients results in downregulation of IL-10 and reduction of myeloid progenitor cells, Cyclic stretch thus increases the abundance of CD40 in endothelial cells through transforming growth factor-beta1/Alk-1 signaling, immune regulation of TGF-beta1 by CD4+CD25+ regulatory T cells may play a fundamental role in the pathogenesis of childhood immune thrombocytopenic purpura, Transforming growth factor-beta has a role in the immune response to malignant disease [review], Gremlin induces lung fibrosis in the mouse and human lung via decreased BMP-signaling and increased transforming growth factor-beta signaling. This effect can be inhibited by BMP-7 administration to the mouse, Transforming growth factor beta1 induces epithelial-to-mesenchymal transition of tumor cells, Serum TGF-beta1 concentration is not a potential biomarker for AD, and TGF-beta1 genetic variants (-800, -509, and +869) are not risk factors for AD., conclusion of this study is that TGF[beta] bioactivation in cholesteatoma epithelium is not augmented but still correlates to survival and migration; in the stroma, TGF[beta]; bioactivation leads to excessive extracellular matrix deposition, This study shows for the first time that TGF-beta1 gene 869 T/C polymorphism may contribute to a genetic risk factor for esophageal squamous cell carcinoma in a Chinese population., The phenotypes of Thiel-Behnke corneal dystrophy are closely correlated with TGFBI mutation., Participation of BRG1 in TGFbeta action suggests a widespread yet differential involvement of BRG1 SWI/SNF remodeler in the transcriptional response of many genes to this cytokine., Data suggest a possible role of TGF-beta/Smad signalling in the pathogenesis of basal cell carcinoma., TGF-beta1 codon 10 C allele plays a role in the development of EBV-related diseases, increased expression of TGF-beta1 mRNA by Leukotriene D4 also occured in A549 and normal human bronchial epithelial cells via a Cysteinyl-leukotriene receptor 1-dependent mechanism, In addition to increased serum TGF-beta1 levels, the T allele of the C-509T polymorphism is related to increased airflow obstruction but attenuated eosinophilic inflammation, hMo-DC differentiated in the presence of physiologically relevant concentrations of TGFbeta1 (2 ng/ml) failed to undergo complete maturation despite adequate stimulation with LPS or LPS+IFNgamma., The early induction of TGF-beta1 at the point of SCI suggests a role in the acute inflammatory response and formation of the glial scar, while the later induction of TGF-beta2 may indicate a role in the maintenance of the scar., SARS coronavirus nucleocapsid protein interacts with Smad3 and modulates transforming growth factor-beta signaling, Single Nucleotide Polymorphisms in transforming growth factor beta 1 and p53 is associated with breast cancer., The C allele of the Leu10Pro polymorphism of TGFB1 may predispose men to a more rapid prostatic cancer progression., The down-regulation of TGF-beta1 expression and its target molecules in insulinomas is a new aspect of this cytokine., Caveolin-1 interacts and cooperates with the transforming growth factor-beta type I receptor ALK1 in endothelial caveolae., These results suggest that Dab2 is a ligand dependent bi-directional regulator of ERK1,2 activity., High levels of TGF-beta-1 are associated with worse survival independent of stage of breast cancer, Signaling competent membrane-bound TGFbeta on cancer cells is thus likely to be a key player in regulating tumor cell interactions with each other as well as with other cells in their microenvironment., TGF-beta 1 is closely related to differentiation of enamel organ and initiation of matrix secretion, OPN is required for the differentiation and activity of myofibroblasts formed in response to the profibrotic cytokine transforming growth factor-beta1., TGF-beta 1 first appeared during canalisation stage in the surrounding mesenchyme and, in the more differentiated stages, was expressed in the cytoplasm of acinar cells throughout the adult gland., Polymorphisms associated with increased expression in the cytokines TNFalpha and TGFbeta1 are overrepresented in the Myelodysplastic syndromes (MDS) population., single nucleotide polymorphisms of TGFB1 at C-509T demonstrates a protective effect against high grade prostate cancer and cases with poor prognosis, These findings suggest that CLU regulates TGF-beta signaling pathway by modulating the stability of Smad2/3 proteins., PPARgamma plays a negative role by directly acting on Smad and ERK phosphorylation in human endometrial cellt reated with TGF-beta1., the ratio of HGF/TGF-beta1 may play a role in transient nephromegaly in children with Kawasaki disease, The aim of this study was to analyse the profile of TGF-beta1 and the expression of its receptor (TbetaR I, TbetaR II and TbetaR III-betaglycan) genes in IPAH and in secondary forms of pulmonary arterial hypertension [Eisenmenger's syndrome patients]., The TGFbeta immunopositivity correlated with sclerotic/fibrotic lesions (interstitial fibrosis, tubular atrophies, vascular hyalinosis/fibrosis, chronicity index), and negatively with glomerular filtration rate., studies suggest that IL-1beta, BK, and TGF-beta1 impair IP receptor-mediated cAMP accumulation by multiple effects on different components of the signaling pathway and that these effects are PKA and p38 MAP kinase dependent., Integration of TGFB and RAS signaling silences RABGEF1 and enhances growth factor-directed cell migration., TGF-beta regulates androgen receptor-dependent gene expression in prostate cancer cells., TGF-beta(1) regulates proliferation through Smad3 signaling in both fibroblast populations; however, it is the levels of HA generated by the cells that influence the outcome of this response., TGF-beta1 secretion, TGF-beta-mediated transcriptional response, expression of activin receptor-like kinase (ALK) 5 protein and phosphorylation of Smad 3 were also enhanced by treatment with N-Shh, there is a significant difference in both allele and genotype frequency at position -800G > A of TGF-beta1 gene promoter between Iranian patients with ulcerative colitis and normal subjects, the +869T/C polymorphism in the TGF-beta1 gene is associated with the severity and intractability of autoimmune thyroid disease., TGF-beta1 acts through PI3K/Akt, which in turn activates IKKalpha/beta and NF-kappaB, resulting in the activations of alphavbeta3 integrins and contributing the migration of chondrosarcoma cells, possible link between TGF-betal gene polymorphisms and the characteristics of peritoneal transport and longitudinal change of peritoneal transport characteristics in CAPD, KSHV evades both the antiproliferative effects of TGF-beta signaling by silencing TbetaRII gene expression and immune recognition by suppressing TGF-beta-responsive immune cells through the elevated secretion of TGF-beta1, TGF-beta1, TbetaRI, and TbetaRII loss of expression correlates with differentiation in human oral squamous cell carcinomas, These results indicate that TGF-Beta1-509 and VEGF-460 polymorphisms were not highly associated with the pathology of pterygium., Downregulation of E6 and E7 levels by IL-4 in CaSki cells is weaker than that exerted by TGF-beta1, a known LCR inhibitor., Results describe TGF-beta binding in human Wharton's jelly., mice overexpressing human latent TGF-beta1 in the skin were protected against anti-glomerular basement membrane crescentic glomerulonephritis, Impaired synthesis of TGF-beta1 by mononuclear cells seems to be present in patients with chronic forms of Lyme borreliosis when compared to those with early stage of the disease, Primary colorectal carcinomas display aberrant expression of vimentin, and have activated Notch and TGFbeta signaling pathways., Together, these findings show that TGFbeta superfamily activation of Smad2/3 is required for repression of spontaneous differentiation under strain., TGF-beta1 increases integrin alpha5beta1 expression through the extracellular signal-regulated kinase (ERK) signaling pathway in human airway smooth muscle cells from asthmatic and nonasthmatic subjects., tagln is a novel target of TGF-beta/Smad3-dependent gene expression in alveolar epithelial type II cells, AMPK inhibits TGFbeta-induced transcription downstream of Smad3 COOH-terminal phosphorylation and nuclear translocation, DAMGO induction of chemokine and chemokine receptor expression requires newly synthesized TGF-beta1 protein in cultured leukocytes., An association was found between 25Pro allele and 25ArgPro genotype with low risk of essential hypertension in male individuals., TGF-beta1 and CTGF mRNAs are correlated with urinary protein level in IgA nephropathy., The role of multinucleated giant cells may thus be different from epithelioid cells by virtue of higher MPT64, more TGF-beta, and reduced caspase 3 which may contribute towards persistence of infection., TGF-beta produced by adjacent regulatory T cells interferes with polarization of T helper cells secretory machinery toward antigen-presenting cells, TGF-beta1/TNF-alpha levels and endothelial cell activation are interrelated in kidney transplant patients., Polymorphic variation in the TGFB1 gene does not play a major role in regulating BMD or susceptibility to fractures. A weak association was found between C-1348-T and lumbar spine BMD in men, and between C788-T and risk of incident vertebral fractures., TGFbeta1 stimulates CCN2 expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism, evidence of gene-gene interaction in the pathogenesis of CF lung disease, whereby high TGF-beta1 production enhances the modulatory effect of MBL2 on the age of first bacterial infection and the rate of decline of pulmonary function., Our data suggest that p107 and p130, but not pRb, and the repressor E2F, but not activator E2Fs, play a critical role in regulating E2F-responsive gene expression., Chondroitin sulphate and its derived hydrolytic fragments (CSf) repress COL1A1 gene transcription through a -112/-61 bp sequence upstream the start site of transcription and imply hc-Krox and Sp1 transcription factors., TGF-beta1-mediates downregulation of TbetaRIII mRNA expression through effects on the ALK5/Smad2/3 pathway., PP2A functions as a negative regulator in TGF-beta1-induced TAK1 activation, Our results suggest that TGF-beta1 gene Arg(25)-->Pro, TNFalpha gene G-308A, and IL-6 gene G-174C polymorphisms are not risk factors or markers of progression in Caucasian patients with IgA nephropathy., Glomerular TGF-beta1 may induce tubular expression of C5b-9. Increased tubular C5b-9 expression may result in interstitial fibrosis through increased TGF-beta1 production., the expression of TGF-beta 1, and proliferation of myofibroblasts within the valves have a potential role in the valvular fibrosis, calcification, and changes in the extracellular matrix that lead to the scarring sequelae of rheumatic heart disease., TGF-beta1-induced HaCaT cell migration is mediated by MMP-14, which regulates MMP-9 expression via JNK signaling, loss of Smad4 contributes to aberrant RON expression and cross-talk of Smad4-independent TGF-beta signaling and the RON pathway promotes an invasive phenotype, the first study reporting on a possible role of TGFbeta1 common haplotypes in the onset of AMI in young patients, FLIP levels decline with TGFbeta1 treatment, suggesting that apoptosis is mediated by caspase-8 and indeed the caspase inhibitor crmA blocks TGFbeta1-induced apoptosis., TGF-beta(1) upregulation of aldose reductase involves transcription factor AP-1., TGFBR1*6A may contribute to cancer progression through RhoA activation in a TGF-beta signaling-independent manner, VE-cadherin promotes breast cancer progression via transforming growth factor beta signaling, transforming growth factor-beta1 plasma levels with kidney allograft rejection, analysis of TGF-beta1-independent changes in protein neosynthesis, p38alphaMAPK, and cdc42 in hydrogen peroxide-induced senescence-like morphogenesis, HIV increases HCV replication through a TGF-beta1 dependent pathway., this signaling pathway was dysregulated in patients with tropical spastic paraparesis, The miR-106b-25 cluster, including miR-106b, miR-93, and miR-25, is involved in E2F1 posttranscriptional regulation and may play a key role in the development of TGFbeta resistance in gastric cancer., identified activin-mediated transforming growth factor (TGF)-beta signaling, platelet-derived growth factor (PDGF) signaling and fibroblast growth factor (FGF) signaling as the key pathways involved in MSC differentiation, Ginsenoside and berberine could promote the secretion of TGF-beta1 in PG cells, but could not change the level of PGE(2)., expression of glomerular TGF-beta1 and alpha-SMA, and interstitial TGF-beta1 is not correlated with clinical course in IgA nephropathy, These results demonstrate that TGF-beta abrogates prolactin-stimulated beta-casein gene expression in mammary epithelial cells through, at least in part, a Smad3-dependent mechanism., Data show that TGFbeta1 codon 25 genotypes Arg/Pro or Pro/Pro are not associated with alcoholic liver cirrhosis., dysregulation can lead to tumor formation, organ fibrosis and the disruption of organ function, gene polymorphisms in TGF-beta1 may be a critical risk factor of genetic susceptibility to gastric cancer in the Chinese population, Genetic background of TGF-beta1 may be involved as a protective factor in the development of aGVHD in HLA-matched sibling BMT in Iranian population., These results suggest that activation of TGF-beta1 by integrin alphavbeta6 contributes to pathological changes and may impair endothelial cell functions in tissues that are chronically infected with cytomegalovirus., frequency of AFP(46-55) CD4(+) T cells is significantly higher (p = 001) in patients with hepatocellular carcinoma than in healthy donors, Lower level gene expression in patients treated with Cyclosporine A may be considered to be a risk factor for gingival overgrowth, results establish the heterogeneous responsiveness of fibroblast populations in the airways to TGF-beta(1) & that such a heterogeneity may contribute, at least in part, to the different pathological outcomes of inflammation in the upper and lower airways, Tryptase activates TGFbeta via a PAR2-independent proteolytic mechanism in human ASM cells and may help understanding the role of tryptase in asthma., data suggest that the altered TGF-beta1 levels are associated with the presence of Hashimoto's thyroiditis, not with the treatment of thyroid dysfunction., study suggests polymorphisms of IL10, TNFalpha & TGFbeta1 do not have major independent role in acute rejection (AR)& hepatitis B virus(HBV)recurrence after liver transplantation & may not be risk factors of AR & HBV recurrence after liver transplantation, secretary factors of adipose-derived stem cells inhibit melanin synthesis by down-regulating the expression of tyrosinase and tyrosinase-related protein 1, which are mainly mediated by TGF-beta1, TGFbeta1 activity during liver fibrosis is specifically antagonized by pleiotrophin, transforming growth factor-beta1 indirectly reduces antigen-presenting cell density in EpM by affecting E-cadherin expression, which might explain the increased susceptibility of abnormal tissue differentiation., This study demonstrates an interplay between TGFbeta1, IL-13 and CCL2 in idiopathic pulmonary fibrosis with a usual interstitial pneumonia histological pathology, where these three mediators feedback on each other, promoting the fibrotic response., Mesenchymal stem cells from patients with osteoarthritis showed significantly increased total TGF-beta, TGF-beta1 isoform, TBR-II, and TBR-III mRNA expression compared to controls., Consistent with our gene expression data, multiple soluble mediators associated with inflammation and tissue remodeling were markedly elevated in the bronchoalveolar lavage fluid of mice expressing hTGF-beta1, These data indicates that full-length WISP-1 and its variant WISP-1va are modulators of proliferation and osteogenic differentiation, and may be novel regulators of TGF-beta1 signaling in osteoblast-like cells., TGF-beta/Smads signaling pathway play a important role on cell growth and metastasis potential in oral squamous cell carcinoma., Relaxin decreased the levels of total and active TGF-beta1 in the extracellular matrix isolated from stress urinary incontinence vaginal fibroblasts., A TGFB1 haplotype was highly associated with increased lung function in patients grouped by CFTR genotype., The aberrant methylation of TSP1 is a novel epigenetic mechanism for suppressing TGF-beta signaling in colorectal cancer., Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced ERK1 and ERK2 activation and promotion of migration and invasion of esophageal cancer cells, Foxp3 mRNA as well as Foxp3 protein was detected in all tumor cell lines, correlating with the expression levels of IL-10 and TGFb1, TGFbeta1 are likely to be involved in HESC decidualization, in HLFs derived from patients with ILDs, the proliferative mechanisms activated by TGF-beta1 are at least in part mediated by an increased release of IL-6, leading to phosphorylation-dependent MAPK activation, TGF-beta(1) production in carcinoma cells was associated with doxorubicine-mediated p53 expression in MCF-7 cells or high basal level of p53 in T47D cells., Transforming growth factor beta induces apoptosis through repressing the phosphoinositide 3-kinase/AKT/survivin pathway in colon cancer cells., The ability of TGF-beta to induce degradation of Ski could be an additional mechanism contributing to its protumorigenic activity., mature human M2 macrophages made permissive to TGF-beta by glucocorticoid-induced surface expression of TGF-betaRII activate in response to TGF-beta1, Transforming growth factor-beta1 protects against pulmonary artery endothelial cell apoptosis via ALK5., These results describe a novel mechanism for the potentiation of TGF-beta1 signaling to induce MMP-9 expression via Smad and MLCK., T(3) regulates furin gene expression via a novel mechanism or in cooperation with TGF-beta to enhance tumor metastasis in vitro and in vivo., fibroblasts from subjects with COPD produced more transforming growth factor (TGF)-beta1, but manifested reduced response to TGF-beta1, Down-regulation of TCF8 expression in ATLL cells was associated with resistance to TGF-beta1, a well-known characteristic of ATLL cells, suggesting that escape from TGF-beta1-mediated growth inhibition is important in the pathogenesis of ATLL, TGF-beta and IL-21 uniquely promote the differentiation of human naive CD4(+) T cells into T(H)17 cells accompanied by expression of the transcription factor RORC2, T beta RI sumoylation controls responsiveness to TGF-beta, with implications for tumour progression, More ductular-type progenitors and fibrosis markers were noted in HF+EtOH mice than in HF mice. The former also expressed more TGF-beta-1., Treg cells were deficient in peripheral blood but not impaired in TGF-beta1 expression or in response to TGF-beta1 stimulation in patients with systemic lupus erythematosus., tumor-induced TGF-beta may actively subvert the CD8+ arm of the immune system into directly promoting tumor growth by an IL-17-dependent mechanism, In the combined region of the 19q13 loci for IA and AAA we identified two candidate genes that are both involved in the TGF-beta signalling pathway., TGF-beta suppressed iNKT cell activation and proliferation and IFN-gamma production while IL-10 was identified as a cytokine involved in stimulating the activation and expansion of iNKT cells that could subsequently suppress NK cell and T cell responses., FK506 has an effect on transforming growth factor beta signaling and apoptosis in chronic lymphocytic leukemia B cells, The TGFbeta1 SNPs studied modulate age at diagnosis and penetrance of familial pulmonary arterial hypertension in BMPR2 mutation heterozygotes., study found different expression of the TGF-beta1, -2 and -3 isoforms in the human corneal epithelium; such differential expression of TGF-betas suggests that each of them may play a specific role in corneal tissue, HDAC6 is a critical regulator of TGF-beta1 induced epithelial-mesenchymal transition and a potential therapeutic target against pathological epithelial-mesenchymal transition, a key event for tumor progression and fibrogenesis, Opposite effects of transforming growth factor-beta activation and rho-associated kinase inhibition on human trophoblast migration in a reconstituted placental-endometrial coculture system., the TGF-beta1-2-3/Smad3 pathway has a role in mediating ovarian oncogenesis by enhancing metastatic potential, Expression of Smad2 is increased in normal NIH-3T3 cells after treatment with recombinant human TGF-beta1; Smad3 is more sensitive to TGF-beta1 than Smad2., Temporal TGF-beta gene expression signature established in mouse primary hepatocytes successfully discriminated distinct subgroups of hepatocellular carcinoma and lung adenocarcinoma in humans., TGF-beta1 might participate in the biological behavior of acoustic neuroma., Concentrations of the immunoregulatory cytokine TGF-beta(1) and of angiogenic factors VEGF and IL-8 were markedly increased within effusions caused by malignancies., study explored the functional consequences of constitutively activating TGF-beta signaling in genetically engineered epidermal melanocytes, Both circulating TGF-beta1 and TGF-beta1 mRNA can be used as sensitive biomarkers for the diagnosis and prognosis of HBV-induced HCC., TGFB1 L10P genotype does not modify the risk of breast cancer in BRCA1 or BRCA2 mutation carriers, Integrin alphavbeta6 is strongly up-regulated in proliferating bile duct epithelia and drives fibrogenesis via adhesion to fibronectin and auto/paracrine TGF-beta1 activation., MT1-MMP-dependent TGFbeta signaling through Alk5 is also required for PGE(2)-induced endothelial cord formation in vitro, and Alk5 kinase activity is required for PGE(2)-induced neovascularization in vivo., TNF[alpha] -308, -238, and TGF [beta]1 -509 SNPs and the TNF[alpha] -308A/-238G haplotype were associated with age-related decline in FEV1 in a group of firefighters., Transforming growth factor beta (TGF-beta) plays an important role in cells proliferation and differentiation as well as in local immunological response., TGF beta 1 polymorphisms (C allele at - 509C>T, T allele at codon10 T>C) contribute to progression of hepatic fibrosis in Chinese with hepatitis B virus infection., Viral gene expression, and specifically the activity of the BKV early promoter, is regulated by TGF-beta in a strain-dependent manner., levels of TGF-beta1 in induced sputum are elevated in asthmatic patients despite treatment with inhaled corticosteroids; TGF-beta1 is involved in the pathogenesis of airway remodeling and resultant functional impairment, the combination of the GG genotype of EGF and the CT genotype of TGFB1 demonstrated synergistic increase in risk of gallbladder cancer, The expression of MMP-2 and -9 in tissue samples from keloids was investigated by immunohistochemistry., EGF contributes to differentiation and migration of myofibroblasts induced by TGF-beta1 through EGF-receptor activation and is important modulator of wound healing and scar tissue formation., Our data do not justify genotyping of the investigated single nucleotide polymorphisms (SNPs) to assess the development of renal dysfunction post-HTx., These data reveal an essential level of TGFbeta signaling regulation mediated by Hsp90., fibrinogen-Mac-1 receptor binding, through induction of IL-1beta, drives the synthesis of transforming growth factor-beta (TGFbeta) by mdx macrophages, which in turn induces collagen production in mdx fibroblasts., TGF-beta1 or activin A but not BMP-2 significantly decreased significantly decreased melanin content and expression of Tyrosinase and Tyrp-1 in the absence of alpha-MSH in melanoma cells, Erythromycin A and EM703 inhibit TGF-beta signaling in human lung fibroblasts via inhibition of p-Smad2/3 through recovery of Smad7 level., MT1-MMP-mediated proteolytic processing of ECM-bound LTBP-1 is a mechanism to release latent TGF-beta from the subendothelial matrix., EBV lytic phase induction in alveolar epithelial cells increased active and total transforming growth factor-beta1 (TGFbeta1) transcript expression, No association was detected between the TGFB1, IL10, TP53, and HMOX1 genes and DGF. The G allele of the TNF polymorphism rs3093662 was associated with DGF in an adjusted analysis., 17beta-estradiol regulates the secretion of TGF-beta by cultured human dermal fibroblasts, TGFB has paradoxical and context dependent effects on proliferation and anoikis in colorectal cancer cell lines., Results imply that androgen signalling through the androgen receptor may positively or negatively regulate TGF-beta1 expression in response to various signals or under different environmental conditions., H. pylori-positive patients revealed a high induction of FOXP3 transcript which correlated positively with inflammation and TGF-beta1 levels., One significant haplotype of TGFB1 is associated with the emphysema phenotype in the Japanese population. Two TGFB1 single nucleotide polymorphisms are associated with the severity of COPD in patients with emphysema phenotype., This study demonstrates increased plasma levels of TSP1, which correlated with increased levels of proinflammatory cytokines in plasma of rheumatoid arthritis patients., Data show that IGF2 activates PI3K and TGFbeta signal pathways during proliferation and differentiation of chondrocytes., The positive correlation of glomerular p-smad2/3 positivity with proteinuria further supports the importance of the TSP-1/TGF-beta system as a relevant mechanism for progression of type-2 diabetic nephropathy, inhibition of TGF-beta1 ligand may act as a negative feedback loop to disrupt the function of all TGF-beta isoforms, Dysregulation of TGFbeta signaling as a possible link between Pez mutation and cancer progression., These data suggest that ADAMTSL2 mutations may lead to a dysregulation of TGF-beta signaling and may be the underlying mechanism of geleophysic dysplasia., The expressions of TGF-beta1 and Smad7 were significantly increased in epithelia of oral lichen planus compared to normal oral mucosa., Ther is an association between the transforming growth factor-beta1 (TGF-beta1) gene polymorphisms rs1800469 (commonly known as T-509C) and rs1982073 (commonly known as Leu (10)-->Pro) and primary vesicoureteral reflux (VUR) and renal scarring., ELF, a TGF-beta adaptor and signaling molecule, functions as a critical adaptor protein in TGF-beta modulation of angiogenesis as well as cell cycle progression., TGF-beta signal transduction is abnormal in B-cell type acute lymphocytic leukemia., Polymorphism of codon25 in the signal peptide region of TGFb1 may contribute to the outcome of HCV infection., Examine the role of transforming growth factor-beta1 signaling pathway in pathogenesis of benign biliary stricture., stromal cell-derived factor-1 and transforming growth factor-beta control the quiescence/cycling switch of CD34(+) progenitors through FoxO3 and mammalian target of rapamycin, although TGFbeta1, an important cytokine in immune regulation, was elevated in monoclonal gammopathies, the SNPs in coding region of TGFbeta1 gene did not confer susceptibility to the development of monoclonal gammopathies in this study, TGFbeta activates PI3K to downregulate PTEN for enhancement of cell proliferation that is independent of SMAD proteins, TGFbeta now stimulated the constitutive TCF transcriptional activation activity associated with the beta-catenin/Wnt pathway in the APC knocked-down cells, TGF-beta1 and SMAD3 may be involved in the pathology of corneal diseases associated with herpes simplex virus type 1 infection., These studies identify F-spondin as a novel protein in osteoarthritis cartilage, where it may act in situ at lesional areas to activate latent TGF-beta and induce cartilage degradation., AZX100, an analogue of the small heat shock protein, HSP20, reduces TGF-beta1-induced CTGF expression in keloid fibroblasts, The tubular and interstitial TGF-beta1 and HIF-1alpha expressions in chronic kidney allograft nephropathy are greater than in other groups., TGF-beta1 single nucleotide polymorphisms are not significantly associated with increased risk of chronic allograft nephropathy and graft survival in Korean renal transplant recipients., The expression of TGF-beta occurs in both granulosa cells and thecal cells throughout antral follicle development., Established liver fibrosis patients had the homozygote G/G TGF-beta genotype, which has been associated with increased development of fibrosis. None of our patients had the G/C genotype., These data suggest that SOCS-1 inhibits high glucose-induced overexpression of TGF-beta1 and synthesis of fibronectin in human mesangial cells, which may be via JAK/STAT pathway., Observed airway smooth muscle cell differentiation into a more contractile asthma phenotype is driven by the autocrine release of TGF-beta 1 in response to activation by mast cell beta-tryptase., polymorphism of the TGF-beta1 gene may be involved in susceptibility to brucellosis and to developing focal forms of the disease in a group of patients from southern Spain., Data suggest that TGF-beta1 single nucleotide polymorphisms probably facilitate the development of liver cirrhosis, while they seem to have a limited role in predicting the occurrence of hepatocellular carcinoma., TGFbeta and retinoic acid downregulated the expression of p63 in immortalized nasopharyngeal epithelial cells and may play a role in regulating differentiation in squamous epithelial cells, The aim of this study was to analyze the effect of TGF-beta targeting on the expression of angiogenic vascular endothelial growth factor (VEGF), in fibroblasts isolated from radiation-induced chronic dermal wounds., Data suggest that TGFB1 gene polymorphism is associated to clinical characteristics suitable to recognize hypertensives with a higher severity of hypertension., a complex role of TGF-beta1 in breast cancer progression, TGFBI promoter methylation can be used as a potential prognostic marker for invasiveness and metastasis in prostate and lung cancer patients., Different roles for TGF-beta and VEGF in the pathogenesis of the cardinal features of diabetic nephropathy, Results describe a new function for the TGF-beta pathway in the regulation of APC to mediate chromatid separation during mitosis., clathrin-independent endocytosis of T beta RIII has a role in regulating both Smad-dependent and Smad-independent TGF-beta signaling, TGF-beta induces formation of F-actin cores and matrix degradation in human breast cancer cells via distinct signaling pathways., Heptatocellular carcinoma-derived TGF-beta1 may act as a chemoattractant for CD105-expressing endothelium and as a promoter of tumor angiogenesis., Data suggest that HHM/Maid regulates a subset of TGF-beta target genes including the Olig1-Smad synexpression group., mechanism of IgG4 induction by regulatory cells involves GITR-GITR-L interactions, IL-10 and TGF-beta., the incidence of TGFB1(transforming growth factor beta 1) *CC polymorphism was lower in Behcets disease cases than controls, Finds lack of association between functional polymorphisms in TGF-beta 1 gene at positions -509, +869 (codon 10), and +915 (codon 25) and silicosis and pulmonary tuberculosis in Chinese iron miners, Elevated miR-21 expression may facilitate breast cancer progression, and TGF-beta may up-regulate its expression, The association between TGF-beta1 polymorphism and virologic characteristics of chronic HCV infection implicated a significant role of host genetic factors on the clinical features of CHC., Novel regulation of vascular endothelial growth factor-A (VEGF-A) by transforming growth factor (beta)1, TGF-beta plays a critical role in mediating cicatricial contraction in proliferative vitreoretinal diseases., Rosiglitazone inhibits the proliferation and migration of Tenon's capsule fibroblasts by decreasing TGFbeta1., Binding elements for ETS and transcription factor AP-2 (TFAP2) were significantly enriched in Smad2/3 binding sites, and knockdown of either ETS1 or TFAP2A resulted in overall alteration of TGF-beta-induced transcription., TGF-beta(transforming growth factor beta1), PDGF-AB (platelet derived growth factor AB) and bFGF (basic TGF-beta, PDGF-AB and bFGF) concentrations in subacromial space were higher than in the serum, High TGF-beta1 in serum is associated with gestational trophoblastic disease., Expression of TGF-beta1 increased significantly 6 mo - 2 y in long-term denervated posterior cricoarytenoid muscles, but after 3 years of denervation, there was no expression at all., dynasore may stimulate PAI-1 protein expression and enhance TGF-beta(1) activity through activation of JNK-mediated signaling in human pleural mesothelial cells, TGF-beta and IL-10 redundantly suppress hepatic inflammation during acute S. mansoni infection while intestinal inflammation is regulated by alternatively activated macrophages., TGF-beta affects human skin mast cells by attenuating degranulation and cytokine production, This study has demonstrated that constant cyclic stretching inhibits adipogenic differentiation of human umbilical cord progenitor cells via autocrine/paracrine stimulation of the TGFbeta1/Smad2 signaling pathway., This study is the first study to use a cell line with a low metastatic rate and TGFbetaRII mutations to demonstrate that restoring TGFbeta signalling increases the metastatic rate., activation of TLR3 can affect the differentiation to myofibroblasts and enhance ECM production via the NF-kappaB-TGF-beta(1)-dependent pathway, 7 different common variants in TGFB1 and TGFBR1 were not associated with an increased risk of bladder cancer, the interplay between NF-kappaB and C/EBPbeta has an impact on the ability of C/EBPbeta to stimulate TGF-beta1 transcription., sTbetaRII attenuates the biological activities of TGF-beta in colorectal cancer, Increased TGFbeta1 is associated with systemic lupus erythematosus., TGFbeta1 and hepatocyte growth factor were major mediators of T-cell suppression by MSCs derived from ALL, HD and NHL, high levels of TGF-beta1 in healthy bowels of patients who undergo ileo-colonic resection for Crohn's disease associated with early clinical disease recurrence, TGF-beta1, VEGF and NO probably have a role in the pathogenesis of Hashimoto's thyroiditis, and development of autoimmunity, Fractalkine and TGF-beta1 levels reflect the severity of chronic pancreatitis in humans., These results indicate that Ski complexes serve to maintain a TGF-beta-responsive promoter at a repressed basal level via the activities of histone deacetylase and histone arginine methyltransferase., analysis of genetic polymorphisms of transforming growth factor-beta1 and its receptors and colorectal cancer susceptibility, hypoxic pulmonary artery smooth muscle cells produce TGF-beta1 that acts in an autocrine fashion to induce IGFBP-3 through PI3K/Akt, Data show no difference between serum concentrations of transforming growth factor-beta1 and ferritin in fatty liver and non-alcoholic steatohepatitis, suggesting that these forms share more common aspects than previously thought., TGFB1 polymorphism L10P is not strongly associated with prostate cancer risk, Transforming growth factor (TGF)-beta might be a central mediator of tissue fibrosis and remodeling in patients with long-standing and recently diagnosed asthma, The presence of SNP (+915G/G) at codon 25 in TGF-beta1 gene may predispose to the development of irreversible bronchoconstriction in asthmatic patients, but only when coincident with the male gender, habitual smoking and relevant duration of the disease., inhibition of caspase-8 by siRNA knockdown partially rescues the apoptotic effects of TGFbeta1, suggesting a role for death receptor signaling components in TGFbeta-mediated death of prostate epithelial cells, Hypercholesterolemia leads to elevated TGF-beta1 activity and T helper 3-dependent autoimmune responses in atherosclerotic mice., The study does not support the association of high myopia with alleles of rs2229336 in TGIF, rs3759223 in lumican, rs1982073 in TGFB1, and rs3735520 in HGF., TGF-beta cytokines may be involved in postsurgical adhesion formation, A new mutation in TGFBI gene, Leu558Pro, was identified in the patients with atypical lattice dystrophy., TGF-beta-mediated activation of RhoA signalling is required for efficient (V12)HaRas and (V600E)BRAF transformation., inhibition of TGF-beta1 suppresses motility and invasiveness of human oral squamous cell carcinoma cells, Results suggest that an epithelial cell response to TGF-beta signaling regulates commitment to cell death and suppression of lactation during the second phase of mammary involution., C-peptide almost completely reversed the morphological changes in proximal tubule cells induced by TGF-beta1., Study in Costa Rica indicates single nucleotide polymorphisms in TGFB1 are associated with airway responsiveness and disease exacerbations in children with asthma. Dust mite exposure may modify the effect., Three SNPs in the Black population that are rare in the Europen population of otosclerosis are SNP2-rs1982073, SNP3-rs1800471 and ZAP-C 100, TGF-beta1 promotes vascular invasion in hepatocellular carcinomas by activating beta1 integrin., preoperative plasma TGF-beta 1 levels in patients with operable breast cancer were significantly higher than healthy controls; those with positive sentinel lymph node had significantly higher levels than those with negative sentinel lymph nodes, These data suggest that TGF-beta is not critical for the differentiation of human Th17 cells, but indirectly favors their expansion because Th17 cells are poorly susceptible to its suppressive effects., transforming growth factor beta(1) (TGF-beta(1)), a pleiotropic cytokine regulating inflammatory reactions.TGFB1 gene polymorphisms (-800G>A, -509C>T, 869T>C, and 915G>C) are not associated with allergic asthma in a Polish population, TGFbeta1 genetic polymorphisms at codon 10 may be involved in a differential susceptibility to T. cruzi infection in these South American samples., These findings suggest that the -509C>T polymorphism in the TGFbeta1 promoter may contribute to the development of the aspirin-intolerant chronic urticaria phenotype, ox-LDL is significantly correlated to TGF-beta in type 2 diabetic patients, HIF-1 alpha and GLUT-1 could cooperate with TGF-beta1, and TGF-beta1 might mediate cross-talk between the inflammatory environment and tumour with a favourable impact on patient survival in colorectal cancer, MMP-9 could up-regulate collagen deposition, possibly through TGF-beta activation, TGF-beta1 elevates TbetaRII homodimerization to some degree and strongly enhances TbetaRI.TbetaRII heteromeric complex formation., The median plasma TGF-beta1 level was similar in all examined groups, but the greatest range of individual plasma TGF-beta1 levels is found in Balkan endemic nephropathy patients., The plasma TGF beta 1 levels change with age. In addition, TGF beta 1 may play a role in the pathogenesis of bronchial asthma., High-affinity binding of TGF-beta1/3 to TGF-betaRII is primarily due to hydrogen bonding between Arg25 and 94 of TGF-beta1/3, and Glu119 and Asp32 of TbetaR-II. Arg25 and 94 are substituted by Lys in TGF-beta2, which binds with low affinity to TbetaR-II., -509C>T polymorphism in the TGF-beta1 gene promoter, impact on the hepatocellular carcinoma risk patients with chronic hepatitis B virus infection., genetic variants are associated with the decreased frequency of Treg in Systemic Lupus Erythematosus patients, In contrast to its link with the ACE D/I genotype, microalbuminuria was independent of TGF-beta-1 polymorphism in a group of never-treated, uncomplicated essential hypertensive men., In newborns of allergic fathers TGF-beta1 levels were significantly lower than in newborns of non-allergic parents., TGF-beta may facilitate airway remodelling by promoting VEGF release through the PI3K pathway, rather than via ASM cell proliferation., myofibroblasts in areas of fibrosis maintain their own phenotype through autocrine TGF-beta1 action, Conservation of the identified hydrophobic motifs in the pro- and mature domains of other transforming growth factor beta superfamily ligands suggests that we have identified a common biosynthetic pathway governing dimer assembly, hENT1 is down-regulated by activation of TbetaRII by TGF-beta1 in endothelium from umbilical veins., disruption of Smad2 function by CDK2 phosphorylation acts as a mechanism for TGF-beta resistance in multiple myeloma, Taking into account that most rare missense alleles are thought to have a biological effect, the data suggest that multiple rare amino acid changing variants in TGF-beta1 may contribute to susceptibility to otosclerosis., HBx may facilitate liver fibrosis by promoting hepatic stellate cell proliferation and upregulating the expression of fibrosis-related molecules like TGFB1, results indicate that TGF-beta1 participates in the regulation of basal expression and the stretch-induced expression of IL-6 and suggest the possible existence in cultured human trabecular meshwork cells of an autocrine loop between IL-6 and TGF-beta1, Report expression of decorin in esophageal cancer in relation to the expression of three isoforms of transforming growth factor-beta (TGF-beta1, -beta2, and -beta3) and matrix metalloproteinase-2 activity., TGF-beta-induced phosphorylation of Smad3 linker sites inhibits its antiproliferative activity, A novel L558P mutation in the TGFBI gene causes an atypical type of stromal corneal dystrophy, TGFbeta activates the transcription factors Smad2 protein and Smad3 protein, inhibits proliferation, and blocks Cdk2 protein activity., TGF-b 1 promoter polymorphism may positively contribute to the development of AIA with rhinosinusitis through gene interaction., TGF-beta1 and MMP2 may be useful molecular markers for evaluating prognosis in Renal clear cell carcinoma patients., the hallmark of our panel of activated human Treg clones is to produce bioactive TGF-beta which has autocrine actions on Tregs and can have paracrine actions on other T cells., TGFbeta-mediated Smad1 phosphorylation appears to occur via different receptor complexes in a cell type-specific manner, TGF-beta1, TGF-betaR1 and TGF-betaR2 gene polymorphisms are not associated with childhood acute lymphoblastic leukaemia., Adipose tissue-derived mesenchymal stem cells differentially respond to BMP-2 and TGF-beta1 with changes in gene expression of collagen-modifying enzymes., a positive correlation between the autocrine expression of YY1 and TGF-beta 1, IGF-1 and FGF-2, known to be involved in the progression of gliomas and meningiomas, After treating of NB4 cells with As(2)O(3), P27(Kip1) and endogenous TGF-beta1 mRNA expressions were up-regulated, and cyclin E mRNA expression was down-regulated., TGF-beta1 overexpression may be associated with in the development and progression of ligamentum flavum degeneration in the lumbar spine., TGF-beta1 -509 C/T polymorphism may not be associated with an increased risk for advanced-stage endometriosis., TGF-beta1 induces human bronchial epithelial cell-to-mesenchymal transition in vitro., TGFB1 stimulation of lung epithelial cells leads to an increase in the cytosolic localization of KH-type splicing regulatory protein, far upstream element-binding protein, hnRNP-L, and hnRNP-H1, concomitant with a decrease in their nuclear localization., sEng levels, but not TGF-beta1 levels, showed a positive correlation with maximum diastolic and systolic blood pressure., TGF-beta mediated epithelial mesenchymal transition has a role in progression of autosomal dominant polycystic kidney disease, Experiments with T cells from healthy donors in the presence TGF-beta1 or IL-10 suggest that these cytokines have a relevant role in T cell responses during cervical cancer progression., Genetic polymorphism of the TGFB1 signal sequence is associated with the response to chemoradiotherapy in head and neck squamous cell carcinoma patients., TNF-alpha abrogated TGFbeta1-induced SMalphaA gene expression at the level of transcription without disrupting phosphorylation of regulatory Smads., Hepatitis B virus X protein shifts hepatocytic TGF-beta signaling from the tumor-suppressive pSmad3C pathway to the oncogenic pSmad3L pathway in early carcinogenic process., The genetic polymorphism at -509 C/T but not at -800 G/A of the TGFB1 gene may play a role in susceptibility of Iranian subjects for colorectal carcinoma., combination of CTLA-4 and TGFbeta1 polymorphisms is associated with the susceptibility of DHF and higher virus load., TGF-beta1 caused apoptosis of pulmonary microvascular endothelial cell, an effect that was also dependent on ALK5 activity., gene expression is decreased following treatment with apigenin, Serum TGFB1 protein levels were positively and significantly associated with plasma renin activity along with the systolic and diastolic blood pressure in blacks but not whites after controlling for age, gender, and body mass index., The effects of shockwave on bone healing and systemic concentrations of TGF-beta1, we review recent findings that directly impact our understanding of the TGF-beta paradox and discuss their importance to targeting the oncogenic activities of TGF-beta in developing and progressing neoplasms, Increases in TGF-beta1 gene expression and its protein level, associated with altered TGF-beta1 receptor profile indicate a functional role for TGF-beta1 in intestinal inflammatory/repair processes in ulcerative colitis., role for RanBP3 in mediating Smad2/3 nuclear export and terminating TGF-beta signaling, There is disregulation in expression of the TGFB1 gene and its receptors as well during isolated Raynaud phenomenon as in systemic sclerosis., TGFbeta1 stimulates VEGFD/VEGFR3 receptor axis activation leading to increased cell migration and invasion by primary intermediate prostate cancer basal cell cultures, 9-ONC might thus sustain further vascular remodeling due to atherosclerosis, not simply by stimulating synthesis of the pro-fibrogenic cytokine TGF-beta1 in vascular cells, but also and chiefly by enhancing the TGF-beta1 autocrine loop., Losartan can reverse left ventricular hypertrophy in elderly patients with essential hypertension partially by lowering plasma TGF-beta1 level., TGFB1 inhibits luteinization in cultured bovine granulosa cells while maintaining an estrogenic phenotype, and this effect was associated with increased apoptosis., There were no correlations among serum TGF-beta1 and pulmonary function test parameters, duration of asthma, and duration of inhaled corticosteroid treatment. These data support the role of TGF-beta1 in airway remodeling in asthma., Helicobacter pylori CagA-positive patients with TGF-B1 -509 T allele had a higher risk for gastric atrophy and lymphoid follicle development., TGF-beta/activin receptor-like kinase-5 signaling is, in part, involved in the regulation of BBB functional integrity, Regulatory cytokines, interleukin (IL)-10 and transforming growth factor (TGF)-beta, were significantly raised in infectious mononucleosis compared to seropositive donor plasma., plasma level is higher in asthmatics, Study shows that TGFbeta-dependent cell migration, invasion and metastasis are empowered by mutant-p53 and opposed by p63., TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma., Disruption of TGF-beta signaling in diffuse-type gastric carcinoma models appeared to accelerate tumor growth, apparently through increased tumor angiogenesis that was induced by decreased expression of thrombospondin-1., Overexpression of Smad7 has been shown to antagonize TGF-beta-mediated fibrosis, carcinogenesis, and inflammation, suggesting a therapeutic potential of Smad7 to treat these diseases., TGF-beta1 drives GATA-4 expression during intestinal inflammation, these two components cooperating to promote epithelial healing., Three-dimensional culture using a radial flow bioreactor induces matrix metalloprotease 7-mediated EMT-like process in tumor cells via TGFbeta1/Smad pathway., upregulation of TGF-beta1 pathway plays an important role in NB4 cells differentiation induced by all-trans retinoid acid, TGFB1 is the first myopia susceptibility gene successfully replicated. The functional significance of rs4803455 or the genuine causative SNPs in linkage disequilibrium with it remains to be determined., transition to increased aggressiveness in melanoma cells requires Id2 upregulation to suppress TGF-beta induction of p15(Ink4b) and thus help to circumvent TGF-beta-mediated inhibition of proliferation., Our results indicate a permanent repression of PAI-1 by ERalpha and suggest a ligand-independent crosstalk between ERalpha and TGF-beta signaling in breast cancer cells., Apoptosis of APL cells induced by As(2)O(3) may be caused by up-regulating TGF-beta1 and P27(Kip1)., Results showed that CT/CC genotypes of TGFbeta1 rs1982073, This study shows that the disappearance of CD34-positive stromal cells and appearance of alpha-SMA-positive stromal myofibroblasts may be associated with transformation of cervical cervical intraepithelial neoplasias to squamous cell carcinomas., Sustained restoration of circulating latent TGFB1 to levels approaching the normal physiological range does not rescue the infertility phenotype caused by TGFB1 deficiency., ectopic Meox2 suppressed epithelial cell proliferation in cooperation with TGF-beta1, and mediated induction of the cell cycle inhibitor gene p21., up-regulation in human colorectal cancer is correlated with upregulation of the TIMP-1 transcript, Suppression of TNF-alpha on TGF-beta-induced CTGF expression is due to the competition of p300 by p65 and Smad4., A dose-dependent increase in viable cells was demonstrated after the IPL irradiation. There was no significant change in mRNA levels of collagen I and fibronectin., and collagen synthesis while VEGF deteriorate tendon properties via vessel formation and destruction of the collagen network., Genotype distributions examined in 38 recipient-donor pairs with either low-grade or high-grade aGVHD did not find significant differences, but some trends were noted in genotype distributions among aGVHD-grade groups, Human atrial fibrogenesis in patients with atrial fibrillation is accompanied by a biphasic response, an early increase and later loss of responsiveness to TGF-beta(1), REVIEW, The intracellular concentration of TAL1 is regulated by TGF-beta, which triggers its polyubiquitylation & degradation by the proteasome. This is mediated by AKT1, which phosphorylates TAL1 at threonine 90., TGF-beta1 inhibited expression of toll-like receptors and attenuated odontoblast responses, suggesting the balance between TLR-mediated inflammation and TGF-beta1 anti-inflammatory activity plays an important role in pulpal inflammation., Pleural mesothelial cells activated by TGF-beta1 undergo epithelial-mesenchymal transition (EMT) and respond with haptotactic migration., induction of membrane-bound TGF-beta1 by IFN-gamma and/or TNF-alpha occurs through de novo synthesis., There is no association between TGFB1 and bone density T(861-20)-C polymorphism in Turkish postmenopausal women., Activation of TGFbeta recruits p300 to the KLF5-Smad complex to acetylate KLF5, and the complex with acetylated KLF5 binds to the Smad binding element and alters the binding of other factors to p15 promoter to induce its transcription, Increased expression of integrin alpha2 and the increased response to TGF-beta1 of hereditary gingival fibromatosis (HGF) fibroblasts may be related to the excessive collagen deposition in HGF patients., TGF-beta1 was up-regulated in endometrial cancers., loss of TGFbetaRII in hepatocellular carcinoma triggers activation of the TNF pathway known to be regulated by TGF-beta(1) network, TGF-beta type I receptor inhibitor LY364947 blocked the up-regulation on TGF-beta(1) and TGF-beta(3) production stimulated by mechanical load, and also blocked the chondrogenesis of human mesenchymal stem cells., Data show that lack of dioxin receptor increases TGFbeta levels, keratinocyte migration and accelerates skin re-epithelialization without affecting cell proliferation or recruitment of inflammatory cells., Recipient RAAS polymorphisms are associated with a higher risk of rejection, graft cytokine expression, graft dysfunction, and a higher mortality after cardiac transplantation., Results show there was high risk of biochemical recurrence associated with tumors that displayed high levels of expression of TGF-beta1, vimentin, and NF-kappaB and low level of cytokeratin 18., TGF-beta signaling mediates intrinsic, stromal-epithelial, and host-tumor interactions during breast cancer progression, at least in part, by regulating basal and oncostatin M-induced CXCL1, CXCL5, and CCL20 chemokine expression, TGF-beta induces phosphorylation at three sites in the Smad3 linker region in addition to the two C-terminal residues., (PPAR)delta regulates extracellular matrix synthesis and degradation through transforming growth factor-beta1 and its effector, Smad3, Data show that inhibitors of clathrin-dependent endocytosis inhibit internalization of cell-surface-bound TGFbeta and promote colocalization and accumulation of TbetaR-I and SARA at the plasma membrane., Active TGFB1 correlates with myofibroblasts and malignancy in the colorectal adenoma-carcinoma sequence., pathogenesis of glioma formation may involve altered AhR regulation of the TGF-beta/Smad pathway, and AhR may represent a promising target for the treatment of human malignant gliomas and other diseases associated with pathological TGF-beta activity, In relation to the T869C polymorphism in the TGF-beta1 gene, results we found an association only between the TC heterozygote and mild lung disease in cystic fibrosis., [review] Emerging evidence indicates that much remains to be discovered regarding the complex and intertwined roles of TGF-beta in inflammation, T cell lineage commitment, antibody generation, immune suppression, and tolerance., Findings suggest that TGFBI and periostin may play cooperative cellular roles and that periostin may be involved in the pathogenesis of 5q31-linked corneal dystrophies., [review] Recent studies highlight the importance of regulatory cytokines TGF-beta, interleukin (IL)-10, and IL-22 in controlling differentiation and function of lymphocytes under steady-state and inflammatory conditions, and minimizing tissue damage., [review] The TSP1/transforming growth factor beta/ connective tissue growth factor axis may contribute in the pro-inflammatory and pro-atherogenic state in patients affected with rheumatoid arthritis., PAI-1-mediated regulation of alphavbeta3 integrin is critical for the control of TGFbeta signaling and the prevention of fibrotic disease., Combined analysis of EGF+61G>A and TGFB1+869T>C functional polymorphisms in the time to androgen independence and prostate cancer susceptibility., TGFB1 promoter SNPs may not be associated with the risk of childhood pre-B acute lymphoblastic leukemia among French Canadians, TGFbeta stimulates Bim transcription by up-regulating the expression of the transcription factor Runx1 through an internal ribosome entry site -dependent mechanism., Ras/MAP kinase pathway, specifically through N-Ras, mediates TGFbeta1 auto-induction and TGFbeta1-induced CTGF expression in human renal tubule epithelial cells., Studies demonstrate the profound significance of TGFB1 in male and female reproductive physiology, and provide a foundation for exploring the significance of this cytokine in human infertility and sexual dysfunction., TGF-beta1 is not associated with the occurrence of restenosis at one year of follow-up of PTCA patients., Data demonstrate a unique functional connection between pRB and TGF-beta in growth control and mammary gland development., CHGA triggered secretion of endothelin-1 from glomerular endothelial cells and TGF-beta1 from mesangial cells cocultured with glomerular endothelial cells., TGF-beta1 may participate in some pathologic changes in vocal cord polyps., Circulating TGFB1 is a reliable biomarker for chronic kidney disease progression in the African-American population., Immunohistochemical study showed moderately elevated expression of TGF-a in endotheliocytes. in all arteriovenous and venous malformations, xIAP has a role in mediating oncogenic signaling by TGF-beta and NF-kappaB in breast cancer cells, IL-17, IFNgamma and TGFbeta levels in CD45Ro and CD45Ra cells from systemic sclerosis patients are differently expressed in lSSc, ldSSc or edSSc phenotypes, PPARdelta plays an important role in skin wound healing in vivo and that it functions by accelerating extracellular matrix-mediated cellular interactions in a process mediated by the TGF-beta1/Smad3 signaling-dependent or - independent pathway., There is an important relationship between the abnormal TGF-beta1/Smad4 signal pathway and genesis and development of oral squamous cell carcinoma., soluble factors in SSc plasma inhibit Treg function specifically that is associated with altered Treg CD69 and TGFbeta expression, Data show there was a significant correlation between the level of TGF-[beta]1 and the levels of MMP-2 and TIMP-2 immunostainings in pancreatic ductal epithelium., The TGF-beta1-acetylcholine axis may regulate colon carcinoma progression and metastasis by altering nitric oxide secretion and influence inflammatory responses by modulating IL-1beta production., Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury., Polymorphisms of TGFB1 genes and survival of patients with gastric cancer, PRDX6 attenuates oxidative stress- and TGFbeta-induced abnormalities of human trabecular meshwork cells., The rate of TGF-beta1-induced osteoclast apoptosis was lower when Bim expression was suppressed., polymorphisms of TGF beta 1 codons 10 and 25 were associated with susceptibility or resistance to brucellosis., The prognostic value of TGF-beta and VEGF in follicular lymphoma is determined in serum samples, suggesting their contribution to tumor microenvironment alterations., TGF-beta1 stimulates expression of activating transcription factor 3 (ATF3) in human breast cancer cells (MDA-MB231)., TGF-beta1 functions to couple bone resorption and formation., Akt, activated downstream from ERK 1/2, was required for TGF-beta1-induced ZEBRA expression and enabled Smad3, a mediator of TGF-beta1 signaling, to be acetylated by direct interaction with the co-activator CREB-binding protein, the present study demonstrated an involvement of TGF-beta1 in the pathogenesis of idiopathic portal hypertension., The TGF-beta1 -509C/T polymorphism is associated with increased risk for chronic idiopathic neutropenia and contributes to the pathophysiology of the disorder by inducing TGF-beta1 overproduction., the renin-angiotensin system and TGF beta 1-related fibrogenic loops are activated as early as 2 months after kidney transplantation., increased serum levels in allergic rhinitis patients following specific immunotherapy; correlation with symptom severity, Compared with human fallopian tubes without adhesions or atresias, the expression of TGFbeta1, TGFBR1 and TGFBR2 all increased significantly in adhesion cases., neither VEGF nor TGF-beta1 can be used as biochemical markers for an early diagnosis in HHT., Transforming growth factor (TGF)-beta induced Nerve growth factor (NGF) and its two receptors in pancreatic stellate cell lines by acitivation of ALK-5 pathway., transforming growth factor beta has a role in the regulation of thyroid function and growth [review], TGF-beta1/TNF-alpha secreted by breast tumor cell lines induce reversion of mammary adipose cells to a fibroblast phenotype., Platelets and activated Tregs co-express latent TGF-beta and GARP on their membranes., Increased TG2 expression can result in induction of transforming growth factor beta1, causing increased synthesis and deposition of matrix proteins, which can be regulated by nitric oxide., Study found that ERK and JNK pathways are involved in TGF-b1-induced fascin1 expression in the human gastric cancer cell line MKN45., Synthesis of activin and TGFB-signaling modulators may be affected by spermatogenic disruption and altered hormone levels in the testis., These results suggest that the increased activity of TGF-beta1 may underlie the depressed function of T cell responses with consequent prolongation of disease course in patients with chronic brucellosis., the TGFbeta-Par6 polarity pathway has a role in breast cancer progression, These results suggest that KLF5 is not only essential for MYC transcription in proliferating epithelial cells but also mediates the inhibitory effect of TGFbeta on MYC transcription., no increase found in interstitial pneumonia, TGF-beta1 plays an important role in the progress of glomerular sclerosis, renal tubular injury and interstitial fibrosis in children with IGA nephropathy., These data demonstrate that the differentiation of normal human lung fibroblasts to myofibroblasts is HDAC4 dependent and requires phosphorylation of Akt., CC genotype of TGF-beta1 polymorphism at codon 10 is associated with occurrence of Giardiasis, gammadelta T lymphocytes with regulatory functions (Vdelta2 Tregs) are induced in vitro in the presence of specific Ag stimulation and cytokines TGF-beta1 and IL-15., TGFbeta signaling has a role in the pathogenesis of psoriasis [review], The study concludes that increasing numbers of single nucleotide polymorphisms in codon 10 of TGFB1 in patients and donors are associated with a worse outcome following hematopoietic stem cell transplantation from unrelated donors., Data show that TGF-beta1 correlated with Bcl-xL and Bax in all colorectal cancers., Ribozyme to TGF-beta1 mRNA abrogates immunosuppressive effects of human colorectal adenocarcinoma HRT-18 cells in vitro and in vivo., HIF-1alpha and TGF-beta may have roles in breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment, a genetic association of TGF-beta1+915 Arg-->Pro at codon 25 polymorphism with Left ventricular hypertrophy in a Chinese hypertensive population., Both TGF-beta and activin signaling pathways are activated on allergen provocation in asthma. Activin-A may contribute to resolution of inflammation., These data demonstrate that mesenchymal stem cells from mice and humans produce Wnt proteins and TGF-beta1 that respectively stimulate lung fibroblast proliferation and matrix production., TGFB1 single nucleotide polymorphisms were found to be associated with asthma at 5% level., TGF-beta is the dominant factor in promoting FAPalpha protein expression., A positive correlation was observed between the TGF-beta1, VEGF expression and IMD scores in infiltrating breast carcinoma, Data show that latent TGF-beta, i.e. both LAP and mature TGF-beta, binds to GARP, which is present on the surface of stimulated Treg clones but not on Th clones., TGFbeta(1) activates EGFR via an H(2)O(2)-dependent mechanism, which subsequently leads to the activation of Erk(1/2)., TGF-beta(1) was detected less often in the colostrum of allergic mothers than in that of mothers without allergy (but the difference was not statistically significant)., Collectively, these data demonstrate that respiratory syncytial virus regulates the cell cycle through TGF-beta in order to enhance its replication., AR could mediate the TGF-beta1-induced FN production, which may associate with AP-1 activation., TGF-beta can override Myc activity despite a stabilizing cancer mutation and induce senescence in myeloid tumor cells, at least in part by induction of Mad1, loss or reduction of BRCA1 alters TGF-beta growth inhibiting activity via Smad3 during oxidative stress responses, observations of hyperexpression of TGF-beta1 in blacks suggest a mechanism for the increased prevalence of renal failure and hypertensive target organ damage in this population, Data show that CD8+LAP+ cells produce IFN-gamma, and these cells suppress EAE that is dependent on both TGF-beta and IFN-gamma., No significant associations were found between FXIII-Val34Leu, FVII-323 del/ins, TGF-beta(1) (915G/C) gene polymorphisms and bronchopulmonary dysplasia phenotype in our population., IL-10 and TGF-beta1, as two important immunoregulatory mediators, participate in middle ear inflammatory response, especially in chronic course of OME in adults., The GG TGF-beta genotype may protect against acute rejection in older recipients during the first year after transplant., Since TGF-beta1 is well known to stimulate the PAI-1 promoter, we suggest that TGF-beta1 and PAI-1 together constitute a positive feedback loop in the development of renal fibrosis in diabetes, we found the CC genotype of the transforming growth factor beta-1 gene to be associated with higher levels of total and specific IgE., transforming growth factor-Beta1 and IL-10 gene polymorphisms may affect host susceptibility to Behcets disease., TGFbeta1 stands as an important biomarker molecule for diabetic nephropathy and diabetic peripheral neuropathyscreening in our series., Expression of diffuse scleroderma TGFbeta-responsive signature stratifies patients into two major groups including a "diffuse-proliferation" intrinsic subset with higher modified Rodnan skin score and a higher likelihood of scleroderma lung disease, found that miR-21 expression was transiently increased after induction of adipogenic differentiation., p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity, Levels of IL-6 and TGF-beta1 have no predictive value for identifying patients with recurrent restenosis., we examine the literature to understand the role of TGF-beta in extracellular matrix turnover, in the development and progression of glaucoma, and in possible therapeutic strategies that can be devised by targeting the TGF-beta signaling pathways.[REVIEW], Data show that sHLA-Cw4 or sHLA-Cw3 alleles induced secretion of TGF-beta1 by ligation of stimulatory KIR2DS1 or KIR2DS2 isoforms., 4E-BP1 gene appears critical for TGFbeta/Smad4-mediated inhibition of cell proliferation., AR is a potent regulator of TGF-beta1 induced expression of FN in human mesangial cells., TGF-beta inhibits IL-1beta-activated PAR-2 expression through multiple pathways in human primary synovial cells, IL1, IL6, and TGFbeta contributed to human Th17 differentiation induced by LPS-activated dendritic cells, TGF-beta1 induced epithelial to mesenchymal transition in human bronchial epithelial cells is enhanced by IL-1beta but not abrogated by corticosteroids., HGF inhibited TGF-beta1 mRNA expression and reduced collagen III secretion., These findings identify the cyclic AMP pathway as a potent but differential and promoter-specific regulator of TGF-beta-mediated effects involved in extracellular matrix homeostasis., Activating variants in the TGFbeta-1 and VEGF gene promoters are associated with post-urinary tract infection renal scar formation in children., Results suggest that TGF-b1 -509C>T polymorphism is not associated with either an increased risk or progression of colorectal cancer., Our results suggest that decorin and TGF-beta1 may have a fundamental role in the pathogenesis of nephrogenic systemic fibrosis., These data describe a novel mechanism of cross-talk between EGFR and TGF-beta pathways, in which RPTP-kappa functions to integrate growth-promoting and growth-inhibiting signaling pathways., We also observed greater expression of Col I and Col III mRNA in BDI patients and significant correlations between their expression and TGF-beta concentration and Smad7 mRNA expression., These results demonstrate how IL-18 activity is regulated by TNFalpha and TGF-beta1, and how IFNgamma production through regulation of IL-18 receptor and T-bet expression., beta1-integrin impairs the TGF-beta1-mediated signals through the altered phosphorylation of the R-Smads, Adenovirus E1A oncoprotein is sufficient to induce Smad7 expression, an inhibitor of TGF-beta signalling., We show differences in expression of glycosaminoglycans are related to the over-expression of TGF-beta and TGF-betaRII in cultured fibroblasts from hereditary gingival fibromatosis and gingival fibroblasts treated with CyA., Nab2 is a novel endogenous negative regulator of Egr-1-dependent TGF-beta signaling responsible for setting the intensity of fibrotic responses, The gene expressions of TGF-beta1 and VEGF were significantly increased at the concentration of 0.1 mg/mL hyaluronic acidnd 0.1 mg/mL Hylan, respectively., -beta1 shRNAs could obviously inhibit the expression levels of TGF-beta1, CTGF, FN and cellular proliferation stimulated by HSA in HK2 cells., beta-catenin-a marker of early stage of colorectal carcinogenesis, as well as TGF-beta1 and HIF-1alpha appear to be devoid of prognostic significance for colorectal cancer in this study of disease free survival, Studies indicate that signaling pathways of STAT3, NOTCH, hedgehog and transforming growth factor-beta (TGFbeta), which are involved in stem cell renewal, differentiation, survival, and are commonly deregulated in HCC., data in the present study suggests that Spred2 is a regulator of TGF-beta1-induced malignance in transformed keratinocytes, TGF-beta1 -509T allele confers marginal protection for early stage 1B but risk for stage II of cervical cancer., This review examines the evidence for a neuroprotective role of TGF-beta1 in Alzheimer disease, and discusses the TGF-beta1 signaling pathway as a new pharmacological target of treatment [review], Our data provide evidence that TGF-beta signaling patterns vary by age and pathologic features of prognostic significance including ER expression., identified TGFbeta- responsive regulatory modules that can function in a cell type-specific fashion. Taken together, our results identify TGFbeta-dependent and -independent cis-regulatory modules of the C4ST-1 gene, The TGF-beta/NF-kappaB/PTEN cascade may be a critical pathway for pancreatic cancer cells to proliferate and metastasize, This preliminary study provides evidence that TGF-beta serum levels are significantly dependent on allergen exposure in allergic rhinitis., changes of TGF-beta1 could be correlated with radiation pneumonitis, The positive rate of bFGF and TGF-beta1 in normal salivary glands were apparently lower than those in malignant mucoepidermoid carcinomas., A recurrent pathogenic R555W of TGFbetaI gene mutation is identified, which appears to be the predominant mutations causing granular corneal dystrophy (GCD) in different populations., TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer., TGF beta was correlated with the expression of Foxp3-mRNA and the frequency of CD4+CD25+Foxp3+ regulatory T cells in patients with chronic hepatitis B and chronic asymptomatic carriers., After 2 years of denervation, TGF-beta1 protein expression in endochylema of myofiber decreased, but after 3 years, no expression of TGF-beta1 protein in endochylema could be found in denervated posterior cricoarytenoid muscles., In primary IgA nephropathy, the T allele of the TGF-beta1 COD 10 C/T polymorphism seems to be associated with more severe histological lesions, higher renal TGF-beta1 mRNA levels and a worse prognosis., Application of miRNA did not down-regulate expression of the collagen I, but downregulated the collagen III gene., The ratio of Asporin to TGF-beta1 (transforming growth factor-beta1) mRNA in patients with severe cartilage damage was higher than that in osteoartritis patients with mild cartilage damage, Exploration of the association between genetic polymorphisms in the TGFB1 pathway and colorectal cancer susceptibility and clinical outcome., TGFB1 509 C/T polymorphism is associated with colorectal cancer in Asians., CTLA-4 blockade resulted in a significant decrease in HIV-specific TGF-beta positive and IL-10 positive CD8+ T cell responses, and a concomitant increase in HIV-specific IFN-gamma positive CD8+ T cell responses., A molecular basis for the antagonism between the PDGF and TGFbeta pathways, and its effect on the control of the vascular smooth muscle cells phenotype., TGFbeta1 expression increases with severity of H.pylori- associated non-metaplastic atrophic gastritis., The expression of TGF-beta1 may be closely correlated with the invasion and metastasis of breast cancer., The breast cancer patients' relapse-free survival was shorter in the TGFbeta1-positive group than in the TGFbeta1 negative group., TGF-beta(1) decreased sGC and PKGI expression in pulmonary artery and aortic smooth muscle cells from adult rats and mice., TGF-beta1 serum levels are significantly lowered in patients with atrial fibrillation and chronic Helicobacter pylori infection., Studies indicate that hepatocyte-specific inhibition of the TGF-beta pathway prevents CCl4 induced liver injury., High levels of Smad3 are required for the tumor suppressor activities of TGF-beta, whereas lower levels are sufficient for the tumor promoting functions., lower blood levels in patients with ischemic heart disease, This is a small case-control study in Caucasians to investigate the role of the TGF-beta1 gene polymorphism T (29) C located in codon 10 in the genetic predisposition to Type 1 diabetes and diabetic nephropathy., A circulating TGF-beta1-mediated mechanism is involved, in both mice and humans, in the excessive deposition of extracellular matrix elements and hypertrophic growth of cardiomyocytes under pressure overload., TGF-beta1-800G>A polymorphism is not associated with cerebral infarction in Han population., The effect of isoflurane on caveolae formation in proximal tubule cells via transforming growth factor beta-1 release is reported., TGF-beta1 c.869T>C polymorphism may be a genetic risk factor for pre-eclampsia (PE) and intrauterine growth restriction-complicated PE., results provide evidence that TGF-beta1 up-regulates expressions of ABCA1, ABCG1 and SR-BI through the LXR alpha pathway in THP-1 macrophage-derived foam cells, MTMR4 plays an important role in preventing the overactivation of TGFbeta signaling by dephosphorylating activated R-Smads that have been trafficked to early endosomes, In contrast with human normal bronchial tissue explants, lung parenchyma produces mesenchymal cells with a myofibroblastic phenotype by intrinsic mechanisms of TGF-beta activation in feed-forward manner., Matrine inhibits the TGFb1 signal transduction pathway in human lung fibroblast cells., Polymorphisms of TGF-beta1 gene do not appear to influence the incidence and clinical course of chronic hepatitis in children., Data suggest that serum TGF-beta(1) levels are potential biomarkers of HD development during the asymptomatic phase of the disease., The present results demonstrated that the TGF-beta3 rs3917187 polymorphism was associated with left ventricular structure, and had an interactive influence with alcohol on LVESD and LVFSH in hypertensive subjects., There were no significant associations of TGFB1 single nucleotide polymorphisms with wheeze, asthma, allergic rhinitis, or eczema., Findings reveal a hyperactive TGFbeta-TGFbetaR-Smad2 signaling axis needed to maintain epigenetic silencing of critical EMT genes and breast cancer progression., This trial failed to confirm previously reported increases in fibrosis in rt-treated breast cancer patients with TGFB1 genotype - any increase greater than 1.36 can be excluded with 95% confidence., TGF-ss signaling, via Smad transcription factors, represents the major fibrogenic cytokine that is strongly elevated during progression of chronic liver diseases, including alcoholic liver disease., TNF-alpha enhances not only epithelial-mesenchymal transition but also cell contraction induced by TGF-beta1., High TGFB1 serum levels are associated with locally advanced non-small cell lung cancer., results demonstrate a critical role for the TGF-beta-FOXO pathway in the maintenance of leukemia-initiating cells, strengthening our understanding of the mechanisms that specifically maintain chronic myeloid leukemia LICs in vivo, JNK/Smad3 pathway plays a critical role in TGF-beta1-induced FXII expression in human lung fibroblasts, TGF-beta1, TGF-beta2, and TGF-beta3 mRNAs were detected in both normal and pseudophakic bullous keratopathy (PBK) corneas., Meta-analysis suggests that the TGFB1 10P allele may be a low-penetrant risk factor for developing breast cancer., The effect of genetic polymorphisms in TGFbeta1/TGFbetaR1 on secreted TGFbeta1 levels in vitro could not be clarified., antiestrogen induces immunosuppression in the tumor microenvironment, through a TGFbeta-dependent mechanism that may contribute to the development of antiestrogen resistance in breast cancer., profiled the gene expression in mesenchymal stem cells in response to TGF-beta, and showed that TGF-beta induced Notch ligand Jagged 1 (JAG1) and smooth muscle cell markers., NKG2D downregulation was primarily caused by tumor-derived tumor growth factor-beta in glioblastoma patients, CXCR4 mRNA and protein expression were upregulated in TGF-beta1-treated MCF-7 cells., Meta-analysis suggests that the TGFB1 T29C polymorphism is not a low-penetrant risk factor for developing breast cancer., The expression of TGF-beta1, its receptor TGFbetaRII, and signaling proteins Smad4 and Smad7 was observed in the majority of colorectal cancer specimens., Fibrosis in radiotherapy-treated breast neoplasms tends to be higher in patients being polymorphic in TGFB1 when compared to patients with wildtype genotype., Data suggests a protective function of the frequent heterozygous C/T genotype against benign airway stenosis (BAS); alternatively, the C/C genotype might be a susceptibility factor for BAS., TGF-beta1 acts through activation of ERK1/2 and the small GTPase RhoA to promote plasma membrane trafficking of the hCNT3 protein., RGZ and CGZ inhibited profibrotic changes in TGF-beta1-stimulated A549 cells independently of inhibition of Smad phosphorylation., TGF-beta1 polymorphisms may serve as a susceptibility marker for tumor HPV16 status among patients with cell carcinoma of the oropharynx, CCN3 counter-regulates positive signals from TGF-beta and Wnt for fibrillin fibrillogenesis and profibrotic gene expression., TGF-beta1 and VEGF were less expressed in fresh frozen bone allografts than in regenerated alveolar bone., Data show that a significant increase in TAFs for VEGF, TGF-beta1, interleukins (IL-4, IL-10) and tumour necrosis factor alpha., increasedTGF-beta/Smad signaling activity by hyperplastic podocytes may lead to mesangial cell matrix overproduction and eventually to podocyte apoptosis and/or detachment, culminating in the development of glomerulosclerosis, the overexpression of TGFB1 and COLIA1 in Hashimoto's thyroiditis suggest that both genes are implicated in fibrogenetic processes during thyroiditis development., The expression rates of MMP-9, VEGF and TGFbeta-1 in poorly-differentiated follicular thyroid carcinoma were higher than those in well-differentiated follicular thyroid carcinoma., The polymorphism 869T/C in TGF-beta1 gene has a significant association with disease occurrence in COPD patients and the C allele might be a risk factor., TGFbeta1 is able to regulate CD133 expression through inhibition of DNMT1 and DNMT3beta expression and subsequent demethylation of promoter-1., These data indicated that Egfr gene activation by TGF-beta is involved in the differences in the expression of cellular matrix genes such as Fn., The onset of sepsis is related to differential TGFbeta-1 and IL-17 gene expression., analysis of the evolutionary origin of the inhibin alpha-subunit, a unique TGFbeta superfamily antagonist, Chronically damaged hepatocytes produce SERPINB3 and TGF-beta, and the anti-protease activity of the serpin might be implicated in TGF-beta1 induction., TGF-beta1 signal pathway may contribute to rhabdomyosarcoma development by inhibiting differentiation., analysis of proteomic changes in human bronchial epithelial cells in response to pro-inflammatory mediator leukotriene E4 and pro-remodelling factor TGF-beta1, generation of ROS by Nox4 mediates TGF-beta1-induced PAI-1 gene expression at least in part through oxidative modification and inhibition of MKP-1 leading to a sustained activation of JNK and p38 MAPKs., Demonstrate that TGFB1 -509 T allele was associated with a reduced risk to develop breast cancer and this allele appeared to act in an additive mode., High glucose stimulated mesenchymal stem cell proliferation through cyclin D1/E and TGF-beta(1) expression via Ca(2+)/PKC/MAPKs as well as PI3K/Akt/mTOR signal pathways., TGFB1 suppresses surface expression of IL-4 receptor in skin-derived mast cells in vitro., TGF-beta1 upregulation in hepatocellular carcinoma patients suggests its role in hepatic carcinogenesis., Data did not find a significant association between TGFB1 polymorphism and the degree of acute mucositis and was not connected to disease-free survival, however, the TGFB1 polymorphism was associated with survival irrespective of the degree of mucositis., two distinct latency-associated peptide regions coordinate stability of the latent transforming growth factor-beta1 complex, AnxA1 promotes metastasis formation by enhancing TGFbeta/Smad signaling and actin reorganization, which facilitates an epithelial- to mesenchymal-like switch., T869C was associated with significantly increased breast cancer risk in Caucasians but not Asians. C509T was not significantly associated with breast cancer risk in any group., Our data show that interleukin-1R-associated kinase 2 is a novel and critical component of TGFbeta signaling., Both variant alleles, TGFB1 869C and XRCC1 28152A, were associated with a lower grade of fibrosis, PSG1 induced up-regulation in monocytes, macrophages, and two human extravillous trophoblast cell lines, antiproliferative effects of aspirin (at antiinflammatory concentration) on human VSMC obtained from bypass patients are mediated by TGF-beta1 and p38(MAPK), Expression of TGF-beta1 was positively correlated with expression of Foxp3 in hepatocellular carcinoma tissues., Meta-analysis strongly suggests that TGFB1 L10P polymorphism may play a low penetrance role in breast cancer susceptibility in Caucasian women., Our analysis suggests that -509C/T polymorphism of Transforming growth factor beta1 has no association with breast cancer risk, TGF-beta1 has a role in how transient interactions between tumor cells and normal fibroblasts modify the acellular component of the local microenvironment to induce long-lasting increases in tumorigenicity and alter the metastatic pattern of cancer cells, The polymorphisms of TGF beta1 +915 G --> C at codon 25 were associated with occurrence of Aatrial fibrillation and serum TGF beta1 level in essential hypertensive subjects., lattice corneal dystrophy type IV was caused by a founder mutation of the TGFBI gene that occurred in a single Japanese ancestor, Data suggest that detectable hepatitis B virus DNA and leucine homozygous TGF-beta1 genotype are risk factors for liver cirrhosis., Data suggest that budesonide pretreatment reduces VEGF release induced by TGF-beta1 in HFL-1 fibroblasts in a dose-dependent manner, and suppresses the increase of phospho-Smad3 and phospho-ERK protein levels., TGF-beta to be antigen induced by the filariae, Meta-analysis suggests that the TGF-beta1 gene -509 T allele polymorphism does not decrease breast cancer risk., Notch and TGFbeta coordinately induce a molecular and functional contractile phenotype by co-regulation of Smad activity at SMC promoters, Increased plasma levels of uPA and TGF-beta1 are associated with the occurrence and development of preeclampsia., Data suggest that in contrast to IL-6 SNP (-174), INF-gamma SNP (+874), IL-10 SNP's (-1082, -819, -592), and TGF-beta1 SNP' (codons 10 and 25), the TNF-alpha SNP(-308) may be associated with the development of generalized aggressive periodontitis., Mesenchymal stem cell (MSC)-derived TGF-beta 1 is largely responsible for an increase in regulatory T cells based on knockdown studies, by an increase in T helper (Th) type 2 cell cytokines, and by MSC-generated TGF-beta 1., Increased levels of circulating CD4-positive CD25high regulatory T cells or TGF-beta might be associated with a favorable clinical course in patients with adult-onset Still's disease., patients with recessive FBLN4 mutations are predominantly characterized by aortic aneurysms, arterial tortuosity and stenosis; evidence for the involvement of altered TGFbeta signaling in the pathogenesis of FBLN4 mutations, The presence of TGF-beta during the primary differentiation of naive T cell receptor-transgenic T cells suppresses cytokine production, proliferation, and encephalitogenicity., TGF-beta1 causes epithelial-mesenchymal transition in HaCaT derivatives, but induces expression of COX-2 and migration only in benign, not in malignant keratinocytes, Through SMAD4, transforming growth factor (TGF)-beta negatively regulates lipopolysaccharide signaling during development of endotoxin tolerance., TGF-beta1 and TGF-beta3 similarly enhance terminal differentiation in an in vitro hypertrophy model of chondrogenically differentiating mesenchymal stem cells., This meta-analysis suggested that the -509C/T polymorphism in the TGF-beta1 gene may be a risk factor for asthma., Disruption of TGF-beta due to transcriptional dysregulation of TGF-beta receptor type II is associated with polyglutamine-induced motor neuron damage in spinal and bulbar muscular atrophy., nasopharyngeal carcinoma cells are not sensitive to growth suppression by TGF-beta1, but the TGF-beta/Smad signaling transduction is functional, EGFR signaling blockade or EGFR knockdown attenuated TGF-beta1-induced PAI-1 expression, implicating EGFR transactivation in TGF-beta1-stimulated PAI-1 expression, The aim of this study was to investigate the effect of TGF-beta1 targeting by antisense oligonucleotides on the RNA synthesis and protein expression of TGF-beta isoforms and their receptors in keloid-derived fibroblasts., These results show basolateral domain specificity in localization of the TGFbeta receptor signaling apparatus., p53 is both indispensable and sufficient for the radiation effect inducing synergistic activation of PAI-1 by radiation and TGF-beta., No association was detected between sequence variations at the TGFbeta1 locus and the risk of late adverse effects of breast radiotherapy., Elevated levels of plasma TGF-beta1 may play a role in pannus overgrowth in cases with aortic prosthetic valve dysfunction., TGFB1+869T>C functional polymorphism may influence NSCLC susceptibility with impact in cellular microenvironment., This study demonistrated that in vitro TGF-beta1 productions play an important role on MDD, but we found no associations between TGF-beta1 and suicidal behavior., Results show that TNF-alpha and TGF-beta1 do not appear to be reliable markers for predicting survival and response to therapy in advanced NSCLC., These results suggest that epithelial-mesenchymal transition induced by TGF-beta1/Snail activation is closely associated with the aggressive growth of cholangiocarcinoma, resulting in a poor prognosis., Results indicate that that levels of TGF-beta1 and TGF-beta3 mRNAs were significantly higher in lungs of chemical gas-injured patients., TGF-beta plays a determinant role in activating and inducing memory cell secretion of interleukin (IL)-9 in humans., these studies support the notion that TGF-beta plays an important role in both bone-and lung metastases of basal-like breast cancer, Agrin binds BMP2, BMP4 and TGFbeta1 with relatively high affinity., TGF-beta1 29T>C genetic polymorphism is an independent factor associated with lymph node metastasis in adenocarcinoma of the lung., Data show that occupancy of EPCR by protein C switches signaling specificity so that activation of PAR-1 by thrombin inhibits TNF-alpha-mediated synthesis of IL-6 and IL-8 and down-regulates TGF-beta-mediated expression of collagen type 4 and fibronectin., TGF-beta 1 gene polymorphisms at promoter positions positions -509 (C/T) and -800 (G/A) failed to correlate with gestational trophoblastic disease., TGF-beta1 inhibition of CX3CL1 expression might contribute to glioma cell invasive properties., both ZEB1 downregulation and Smad7 overexpression contribute to resistance to TGF-beta1-mediated growth suppression in adult T-cell leukemia/lymphoma., TGF-beta, leading the tissue invasion mediated by MMP-2, is a strong promoter of tumor progression., The MMP-1, COX-2 and IL-1beta expression in synovium decreased depending upon the severity of knee osteoarthritis, while the TGF-beta expression increased., No significant difference was found in codon 10, codon 25 genotype frequencies between patient with SSc and the control group., Bystander cell death can be induced in T98G glioma if a large enough radiation stress is applied and TGF-beta1 plays a downstream role in this response., Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway, TGFBIp expressed by peritoneal cells increases the metastatic potential of ovarian cancer cells, interleukin 1beta and tumor necrosis factors alpha and beta, but not transforming growth factors alpha and beta, strongly induced HA synthesis by NF-kappaB pathway, activating hyaluronan synthase 2, Mutation of TGF B1 gene with multiple anterior stromal geographic corneal opacities in both eyes., affects differentiation of natural killer cell subsets, The increased expression of TGF-beta1 and IL-8 in bronchoalveolar lavage fluid may be involved in abnormal lung development and maturation in neonates with bronchopulmonary dysplasia (BPD)., The effects of RGD peptide immobilization onto macro-porous alginate scaffolds on TGF-beta1-induced human mesenchymal stem cell chondrogenesis were evaluated., Intense pulsed light can suppress the secretion of TGF-beta1 at lower intensity and promote secretion at higher intensity., TGF-beta1 is involved in the pathogenesis of both keloids and hypertrophic scars, CD4(+)CD25(+) Treg cell level and the serum level of IL-2 and TGF-beta all are related to incidence and severity of acute graft-versus host disease., TGFB1 is involved in vascular growth and transformation processes which may play a role in the development of Moyamoya disease., The influence of 14 sequence variants detected in IL-10, TGF-b1, VEGF, and their associated receptors were evaluated as effective predictors of breast cancer clinical outcomes., Coordinated expression of TGF-beta isoforms and of CTGF may be involved in normal glomerulogenesis and possibly in maintenance of glomerular structure and function at adult age., miR-146a might influence proliferation of APL cells through TGF-beta1/Smad signal transduction pathway during ATRA induction., Smad3 phosphorylation in the linker region and Smad transcriptional activity are directly or indirectly controlled by JNK1, and provide a putative mechanism whereby JNK1 promotes TGF-beta1-induced epithelial-to-mesenchymal transition., Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tumor growth., TGF-beta1 and E-cadherin are closely associated with the metastasis of ovarian carcinoma., Elevated TGFbeta1 levels are associated with viral clearance following therapy in patients with hepatitis C virus., disabled homolog 2 acts as a tumor suppressor by dictating tumor cell TGF-beta responses, identify a biomarker for squamous cell carcinomas progression., Genome-wide transcriptional profiling that PPARbeta/delta and transforming growth factor-beta (TGFbeta) pathways functionally interact in human myofibroblasts and that a subset of these genes is cooperatively activated by TGFbeta and PPARbeta/delta., These results uncovered a novel mechanism for the GSK3beta negative regulation of TGF-beta1/Smad3 and Angiotensin II/ Smad3-mediated transcription and apoptosis by the identification of a crosstalk between GSK3beta and Smad3 signal pathway., Levels of TGF-beta secretion after 4 hr of treatment with lipoic acid are not remarkably elevated, an indication that lipoic acid may be able to mimic TGF-beta-mediated cell response., Cancer cell lines with inactivating mutations in Fbxw7 show enhanced levels of TGIF1 and attenuated TGFbeta-dependent signaling, These results suggest that TGF-beta1 plays a pivotal role in synovial fluid from patients with rheumatoid arthritis-induced differentiation of human adipose tissue-derived mesenchymal stem cells to alpha-SMA-positive cells., A variant in the fibrillin-3 gene is associated with TGF-beta and inhibin B levels in women with polycystic ovary syndrome., Endothelial progenitor cells (EPC) may differentiate into smooth muscle cell-like cells through an endothelial-to-mesenchymal transition-like process. TGFbetaI plays an important role in the fate of EPC., SNPs of TGFB1 rs1982073 and FGFR2 rs1219648 not associated with breast cancer risk in North China women of Han nationality; breast cancer patients with C allele in TGFB1 rs1982073, or the G allele in FGFR2 rs1219648 more likely to have aggressive tumors, Loss of beta1-integrin enhances TGF-beta1-induced collagen expression in epithelial cells via increased alphavbeta3-integrin and Rac1 activity., TGF-beta1 is a central stimulus of the events leading to chronic progressive kidney disease, we demonstrated a significant association of the relative TNF-alpha/B2M mRNA expression and the relative TGF-beta 1 /B2M mRNA expression in white blood cells of 118 Germans., function for periostin in asthma in stimulating the TGF-beta signaling pathway in a mechanism involving matrix metalloproteinases 2 and 9., transcription of integrin-alpha(E) genes is induced by TGFbeta1 signal; expression of integrin-beta(7) is constitutive but can be increased by TGFbeta1; expression of Itg-alpha(E) and Itg-beta(7) is decreased in TGFbeta-signal deficiency with a compensatory increase in alpha(4)beta(1), We report that interleukin-17 levels are decreased, whereas TGF-beta levels are increased, among Asian Indians with metabolic syndrome, airway smooth muscle activation of plasminogen by uPA is accelerated in a collagen-rich environment in which the inhibitory effect of TGF-beta is attenuated in association with greater uPA expression induced via beta1-integrin signaling, Epstein-Barr virus latent membrane protein 1 and transforming growth factor--beta1 synergistically induce epithelial--mesenchymal transition in lung epithelial cells, We show new data linking TGFB1 rs4803455 and myopia-related quantitative traits., The TGFbeta1 level in cytoplasmic extracts of metastatic axillary lymph nodes may be a promising biomarker of invasiveness for breast cancer patients., Tendon sheath fibroblasts can transfect with antisense TGF-beta1 gene successfully and can decrease production of collagen I, collagen III, and TGF-beta1, which were factors of tendon adhere formation., Results indicated that TGFbeta and its associated signaling molecules facilitate the undifferentiated proliferation of hES cells in vitro., TGFbeta1-induced Smad2 nuclear translocation is negatively regulated by intracellular Ca(2+) in OLI-neu cells and increased intracellular Ca(2+) concentrations block Smad2-mediated transcription of TGFbeta target genes., Forced expression of human TGF-beta 1 gene into mouse myeloma cells, and other cell types including murine CD4-positive CD25-negative T cells, makes the surfaces of these cells latency associated peptide (LAP)/TGF-beta-positive., These data reveal a significant down-regulation in the expression of extracellular matrix components and TGF beta, in stromal cells when grown in the presence of two metastatic prostate cancer cell lines, The regulation of connective tissue growth factor, collagen I and III, fibronectin, plasmin system regulators, matrix metalloproteinases and their inhibitors as well as alpha-smooth muscle actin was consistent with a suppression of ECM, gene polymorphisms is associated with protection or susceptibility to dengue hemorrhagic fever, IL-15 counteracted TGF-beta1-mediated alpha-SMA expression. Moreover, TGF-beta1-induced expression of collagen, fibronectin and connective tissue growth factor was attenuated by addition of IL-15, The mean concentration of TGF-beta1 in patients with valvular heart disease was significantly lower than the mean in the coronary artery bypass graft group., Increased plasma levels of TGFbeta1 and an altered ratio bioactive/total TGFbeta1 in bone marrow are not peculiar of patients with primary myelofibrosis., single non-productive Dirofilaria worms elicit a strong expression of TGF-beta, TGFB1 induced the phosphorylation of Smad2 at both the linker and C-terminal sites., investigated the relation between epithelial-mesenchymal transition criteria and laminin-332 expression in a cell culture model of transforming growth factor beta-1 (TGFbeta1)/epithelial growth factor (EGF) long time co-stimulation., CT or TT genotype of TGF-beta1-509C/T polymorphism was associated with a significantly higher RIET risk (adjusted hazard ratio [HR]=2.47; 95% confidence interval, respectively, compared with the CC genotype in radiotherapy-treated lung neoplasms., data suggest that Jagged/Notch signalling is required for a subset of TGFbeta1-responsive genes, and that complex signalling pathways are involved in the crosstalk between TGFbeta1 and Notch cascades in kidney epithelia, TGF-beta1 expression in occluded fallopian tubes was negatively correlated with postsurgical pregnancy outcome in infertile women, independent of adhesion severity or patient age, Level of TGF-beta and IL-10 inversely correlated with malaria vaccine immunogenicity., TGF-beta1 activates beta-catenin signalling, increases beta-catenin nuclear translocation and interacts with LEF/TCF to regulate gene expression in dental pulp cells., Meta-analysis suggested that 29T/C has no association with a trend of breast cancer risk., IL-1alpha, IL-6 and TGF-beta are increased in mucosa-predominant tissues in patients with oxidative stress and severe obstructive sleep apnoea, TGFbeta and EGF signaling pathways synergistically induce epithelial-mesenchymal transition and render epithelial ovarian cancer cells a more invasive phenotype., AMH thus exemplifies a new mechanism for receptor engagement in which interaction with the type II receptor promotes pro-region dissociation to generate mature ligand., New Smad4 dependent and independent TGF-beta responses in colon carcinoma cells, were identified., A conserved stem loop motif in the 5'untranslated region regulates TGFb1 translation., TGF-beta1 enhances BMP-2-induced ectopic bone formation., TGF-b1 protects against mesangial cell apoptosis via induction of autophagy., The simultaneous expression of Endoglin (CD105), transforming growth factor (TGF)-beta1 and TGF-beta receptor (R) II were quantified in normal human colon, pre-malignant dysplastic tissue, and invasive colon cancer specimens, The 869 T > C and 915 G > C polymorphisms within the TGF-beta1 gene were associated with diabetic nephropathy. Lower cholesterol/triglycerides levels were observed in TT homozygotes for the 869 T > C polymorphism., TGFbeta1 down-regulated expression of prolactin and IGFBP-1 in endometrial stromal cells in SMAD4-dependent and SMAD4-independent manners., Serum concentrations of cystatin C and transforming growth factor-beta1 (TGF-beta1) were measured in patients with thyroid dysfunction., TGF-beta1 seems to play an important role in inducing fibroblastic differentiation of PDL stem/progenitor cells., the precise mechanisms of gastric cancer cell growth by TGFbeta stimulation through ADAM activation and HB-EGF shedding were investigated., TGF-beta1 led to elevated levels of the SMAD signalling cascade, indicating an abnormal sensitivity of keloid-derived fibroblasts to this cytokine, IL-25 production is differently regulated by TNF-alpha and TGF-beta1 in the human g, TGFbeta1 and TGFbeta3 play separate yet complimentary roles in achieving cell cycle arrest and EMT/apoptosis and cell cycle arrest is a prerequisite for later cellular changes in palate development., ginsan acts as an effective anti-fibrotic agent in the treatment of pulmonary fibrosis by blocking multiple TGF-beta1 signaling pathways., FSH and TGFbeta1 play important roles in regulation of ovarian angiogenesis during follicle development., Smad2/3 and p38 MAPK differentially regulate TGFB1-induced epithelial-mesenchymal transition in pulmonary epithelial cells., miR-24 might play an important role in modulating the induction of TGFbeta1 mediated by cyclical mechanical stress through direct targeting of FURIN., TGF-beta1 induced signal transduction in hepatocytes may contribute to tumor suppression (growth inhibition and apoptosis), and to liver tumor progression and invasion (EMT and acquisition of a stem-like phenotype)., Microbe-associated neuraminidases can directly activate LTGF-beta and TGF-beta plays a pivotal role protecting the host from influenza pathogenesis., A significant amount of IL-6, TNF-alpha and TGF-beta was spontaneously produced by peripheral blood mononuclear cells from pulmonary TB patients in Gabon, reflecting most probably a systemic, unspecific inflammation., Macrophages as well as vascular endothelial cells but not fibroblasts show a strong expression of TGF-beta, a strong inducer of extracellular collagen deposition in the progression of neurogenic claudication., SKIP is required for epithelial mesenchymal transition and invasiveness induced by TGF-beta1 in transformed cells, The culture supernatant of mesenchymal stem cells isolated from stage III breast cancer patients induced upregulation of the mRNA expression levels of IL-4, TGF-beta1, IL-10, CCR4 and CD25 in peripheral blood T lymphocytes., The TGF-b1 was highly expressed in VKC conjunctiva in association with Smads., TGF-beta1 overexpression in malignant cells is caused, at least in part, by a runaway of TGF-beta1 auto-induction through ERK activation because of a defective recruitment of PP2A-Balpha by TbetaRI., TGF-beta1 gene rs11466345 G allele was likely to be a genetic susceptibility factor for essential hypertension in the Xinjiang Han population., Peritoneal fibrosis induced by TGF-beta1 may provide a favorable environment for the dissemination of gastric cancer., MicroRNA-155 has a role in targeting SMAD2 and modulating the response of macrophages to transforming growth factor-beta, TGF-beta and oxidative damage both upregulated tenascin-C mRNA but only TGF-beta induced synthesis and release of a distinct protein isoform, The establishment of the self-sustaining TGF-beta and SDF-1 autocrine signaling gives rise to tumor-promoting carcinoma-associated fibroblasts myofibroblasts during tumor progression., Stimulation with recombinant human TGF-beta1 (10 ng/ml) significantly increased the expression levels of PRG4 supporting the therapeutic application of rhTGF-beta1 in the treatment of temporomandibular joint osteoarthritis., TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P., although BM MSCs do not exert a significant role in the immune deregulation associated with CIN, they contribute to the inhibitory microenvironment by overproducing TGF-beta1, at least in patients displaying the 509C/T polymorphism., Connective tissue growth factor is critical for TGF-beta1-induced gingival fibroblast-myofibroblast transition., data indicate that WFIKKN proteins are antagonists of GDF8 and GDF11, but in the case of TGFbeta1, BMP2 and BMP4 they function as growth factor binding proteins, The TGFB1 gene polymorphism -509C/T may play a potential role in the severity of persistent allergic rhinitis in childhood., Increases in expression of TGF-beta1 and VEGF, as well as in the numbers of fibroblasts, were observed in granulation tissue obtained from patients with benign airway stenosis., Pancreatic ductal adenocarcinoma cells repress let-7 microRNA, in part through increased TGF-beta1-mediated expression of MT1-MMP, TGF-beta1 activates VEGF expression via multiple routes including Smad3, HIF-2alpha and HuR signaling, The results of this study suggested that the TT genotype of 869T/C might be a risk factor of IS in Chinese, especially in female., This is the first study to show that polymorphisms in anti-inflammatory cytokine genes are associated with susceptibility to Graves' ophthalmopathy (GO)., hs-CRP and TNF-alpha, but not TGF-beta, IL-6, IL10 or proBNP may have a role in cardiovascular event risk in patients with atherosclerotic occlusive disease, findings suggest that inhibiting PRL-3 expression might be an important mechanism through which TGFbeta suppresses metastasis in colon cancer, The TGF-beta1 mediated secretion of endothelin-1 and TGF-beta2 is mediated by Rho kinase activation in hepatic stellate cells., we found an overall reduction in TGF-beta signaling in multiple sclerosis, these results elucidate a novel mechanism through which the TGF-beta pathway regulates the cancer stem cells property by interfering with the tumor suppressor ATM., A strong negative correlation between LTBP-1 and P-Smad2 immunoreactivity was found, implying that LTBP-1 is not likely to contribute directly to the increased levels of TGF-beta activity in malignant mesothelioma., Gly915Cys TGF-beta1 polymorphism is not associated with rheumatoid arthritis (RA), but soluble TGF-beta1 serum level scores are related with functional class in a Spanish RA population., TGFbeta1, TNFalpha and LIF expressions showed increased level in the untreated patients with de novo acute myeloid leukemia., TGF-beta induced the expression of Nox4 while at the same time inhibiting the expression of MnSOD and catalase in airway smooth muscle cells., Data suggest a novel mechanism for MEK1 in regulating the sensitivity to TGF-beta signaling by stabilizing TbetaRII., TGF-beta2 may have a role as a protective factor in the course of sarcoidosis, These data suggest that accumulation of age-related epigenetic modifications leads to suppression of TGF-beta signaling and contributes to ovarian carcinogenesis., intense pulsed light irradiation rejuvenates skin collagen via the bidirectional regulation of MMP-1 and TGF-beta1 mediated by MAPKs in fibroblasts, The atrial TGF-beta1 mRNA expression level could predict the persistence of atrial fibrillation following rheumatic valvular surgery and concomitant radiofrequency Maze procedure., In patients with a smoking status of <40 pack-years, the TGF-ss1 polymorphism, C-509T, was significantly associated with the prognosis of advanced non-small cell lung cancer, and the TT genotype was an independent prognostic factor for poor survival., The C allele in TGFB1 was associated with increased risk of atherosclerosis in older Chinese men., Data support the thesis that TGF-beta is regulated by TNF-alpha, inhibition of ADAM17 leads to upregulation of TGFbeta signaling. Adding a new level of complexity to the function of ADAM17, we finally show that, through the cleavage of VASN, the metalloprotease controls TGFbeta-mediated epithelial-to-mesenchymal transition, results indicate that the DeltaNp63 promoter is activated by the keratinocyte-specific TGF-beta signaling mechanism with Smad2 and IKKalpha in squamous cell carcinomas, Together, we show that micro-CT is a powerful tool to assess pulmonary fibrosis in mice, using both visual assessment and semi-automated quantification algorithms., Coexistence of Nme1-1465 T>C and TGFbeta1-509 T>C genes may provide a synergistic effect of increasing the susceptibility of gastric carcinogenesis., KLF4 is profoundly degraded in response to TGF-beta signaling, atRA and TGF-beta, but not IL-2, enable CD4+CD25+CD45RA+ cells to express a phenotype and trafficking receptors similar to natural Tregs, TGF-beta mRNA expression positively correlated with HSP70 expression in skin fibroblasts exposed to ultraviolet B radiation., A hypofunctional genetic haplotype termed H3 tagging the 5' region of the TGFB1 gene encoding TGF-beta1 was identified and was associated with lower TGF-beta1 plasma concentrations and reduced secretion in irradiated peripheral blood mononuclear cells., conclude that Nrp1 is a co-receptor for TGF-beta1 and augments responses to latent and active TGF-beta, The TGF-beta-mediated suppression plays in tumor immunology, these findings unveil necessary considerations in formulation of CD8+ T cell-related cancer immunotherapy strategies., TGF-beta1 C-509T and T869C polymorphisms may be associated with an increased risk of GCA in north China., Oxidative stress-mediated decorin GAG chain synthesis triggers TGF-beta signaling and mineralization of vascular smooth muscle cells in vitro., Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis, transforming growth factor-beta-stimulated collagen production in fibroblasts is attenuated by quercetin-induced heme oxygenase-1, TGF-beta disables the transition of primed autoreactive CD8-positive T cells to cytotoxic effectors in double-transgenic mice and decreases generation, or maintenance, of CD8+ memory T cells within the pancreas, impairing their diabetogenic capacity., SMAD3 mutations in the TGF-beta pathway cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis, these findings provide a mechanism supporting TGF-beta1 as a key factor for the proclivity of pancreatic cancer to early metastasis, endorsing the relevance of TGF-beta1 in pancreatic cancer progression., Elevated expression of BRCA2 correlates with TGF-beta1 and HER2 in breast cancer and these three factors may act in synergy to promote cancer., Fibroblast growth factor-2 promotes mitral valve interstitial cell wound repair, at least in part, through the TGF-beta/Smad2/3 signaling pathway., In patients with liver cirrhosis, splanchnic organ-derived latent TGF-beta1 is negatively associated with the liver function. Interleukin-6 was negatively correlated with latent TGF-beta1., Microdeformations produced by the combination of polyurethane foam and suction are associated with increased fibroblast proliferation and up-regulation of gene expressions in fibroblasts., TGF-beta1 down-regulates Runx-2 and ALP in human dental pulp cells via ALK5/Smad2/3 signaling. These events may play important roles at specific stages of pulpal repair and dentinogenesis., High TGFB1 is associated with ovarian cancer., TGF-beta1 diminishes collagen production during long-term cyclic stretching of engineered connective tissue by decreasing ERK signaling, There is a distinct increase in serum TGF-beta1, a week post hip fracture repair, lasting for at least a month, which is significantly higher in patients with post-op. complications, findings suggest that TGF-beta1 regulates EMT via stimulating expression of MTA1, which in turn, induces FosB to repress E-cadherin expression and thus, revealed an inherent function of MTA1 as a target and effector of TGF-beta1 signaling in epithelial cells, SPARC is highly expressed in scarred human Tenon's capsules in vivo and can directly induce and amplify the effect of TGF-beta on HTF cell proliferation and collagen gel contraction in vitro, the TGFBI R555W mutation may have a role in a new granular corneal dystrophy type I phenotype, The TGFB-1 level showed highly significant differences in all stages of fibrosis in patients in contrast to controls. There was highly significant positive correlation between TGFB-1 and body mass index., Low plasma TGF-beta1 concentrations were found in children with severe dengue haemorrhagic fever compared with healthy controls., TGF-beta blockade decreases ascites by both inhibiting ascites formation and improving ascites drainage, Data demonstrates that TGF-beta-dependent induction of IRAK-M expression is an important, clinically relevant mechanism by which tumors may circumvent anti-tumor responses of macrophages., Estimation of plasma TGF-beta1 during the course of chemotherapy might not be a reliable biomarker for predicting therapeutic efficacy in non-small cell lung cancer, Specific cytokine gene polymorphisms in IL-6, TGF-beta1, and IFN-gamma seem to be associated with worse prognosis as well as with measures of disease severity in dilated cardiomyopathy, These Ph(+) putative CML hemangioblast up-regulated TGF-beta1 and result in activating matrix metalloproteinase-9 to enhance s-KitL and s-ICAM-1 secretion, TGF-beta expression, oxidative stress, and myofibril loss were greater in the atria of patients with atrial fibrillation than those with sinus rhythm., Using siRNA approach the demonstrated that hepatitis C virus-induced furin and thrombospondin-1 (TSP-1) are involved in the proteolytic activation of TGF-beta1., The ability of DLX4 to counteract key transcriptional control mechanisms of the TGF-beta cytostatic program could explain, in part, the resistance of tumors to the antiproliferative effect of TGF-beta., Link between heterogeneity in TGF-beta signaling and tumor promotion by tumor stromal cells., TGFbeta subtypes (1, 2 and 3) affect terminal differentiation of in vitro cultured hBMSCs differently, No association between the TGFB1 gene polymorphism and gingival overgrowth was revealed in kidney transplant patients administered cyclosporine A., An E3 ligase, neural precursor cell expressed, developmentally down-regulated 4 (Nedd4), also was found as one of the important modulators of the p-Smad1 in both BMP-2 and TGF-beta1 action., Mutations R555W and R124H in TGFBI were identified in three Chinese families with granular corneal dystrophy, Recombinant adeno-associated virus-encoded inducible transgenic interleukin (IL)-2, but not transgenic transforming growth factor (TGF)-beta1, is sufficient to increase Foxp3-positive regulatory T cells in type 1 diabetes., No significant associations were identified for TGFbeta1 SNPs as a contributor to COPD susceptibility., HTRA1 controls the amount of TGF-beta1 via cleavage of proTGF-beta1 in the endoplasmic reticulum., These data help to better understand the negative feedback loop in the TGFbeta signalling system, and enlighten an interesting role of Sp1 to regulate TGFbeta response, effect of transforming growth factor-beta (TGF-beta) on ADAMTS-4 expression in macrophages along with the regulatory mechanisms underlying its actions, TGFbeta1 induced MAD1 expression by recruitment C/EBPalpha/beta heterodimers, SP1, and SMAD3 binding to promoter of the MAD1., Data support feasibility of larger-scale studies on potential association between TGF-beta1 signal sequence and IL-6 promoter polymorphisms and occurrence of developmental hip dysplasia and (un)related severe osteoarthritis, This study demonstrates that in the presence of TGF-beta1, multi-lineage progenitor cells undergo smooth muscle cell lineage differentiation., Degranulation of skin mast cells can be an important mechanism of TGFbeta secretion in systemic sclerosis., TIAF1 undergoes self-aggregation in response to TGF-Beta1., These results suggest that the -509 T allele of the TGFB1 gene may contribute to overall susceptibility to infection by Leishmania and to severity of the clinical disease., Urinary TGF-beta1 may be a useful non-invasive tool for the differential diagnosis between obstructive uropathy and non-obstructive uropathy in children., C allele at codon 25 of the TGF-beta1 gene is a marker for the development of graft fibrosis in liver transplant recipients with HCV reinfection., The effect of IFNgamma on epithelial cell migration and proliferation could be completely blocked by neutralizing antibodies against TGFbeta indicating that these effects are mediated through a TGFbeta dependent pathway., the TGF-beta and p120-associated noncanonical beta-catenin pathways are important in pelvic lymph node metastasis in early-stage cervical cancer, The prognostic impact of TGF-beta1, NF-kappaB p105, PKC-zeta, Par-6alpha, E-cadherin and vimentin in non-gastrointestinal stromal tumor soft tissue sarcomas, was investigated., Toxoplasma gondii GRA1 stimulates apoptosis of monocytes through autocrine TGF-beta1 signaling., a novel mechanism in which latent TGF-beta1, thrombospondin 1, and furin form a microRNA-mediated regulatory feedback loop., Expansion of CD16- NK cells in peripheral blood of patients with melanoma was associated with elevated plasma transforming growth factor-beta (TGF-beta levels (median 20 ng/ml, Spearman's rho = 0.81, P = .015))., aryl hydrocarbon receptor ligand ITE inhibits TGFbeta1-induced human myofibroblast differentiation, Findings offer insights into how MNK1 pathways control translation of cancer-related mRNAs including SMAD2, a key component of the TGF-beta signaling pathway., This is the first study to show evidence for renal tubular cells showing signs of epithelial-mesenchymal transition (EMT) in large stone-containing kidneys; TGF-beta may trigger EMT, which at least in part contributes to large stone-induced renal fibrosis., demonstrated the existence of an autocrine TGF-beta/ZEB/miR-200 signaling network that regulates plasticity between epithelial and mesenchymal states., Data show that TGF-beta pathways operate during ovarian fetal development, and fibrillin 3 is highly expressed at a critical stage early in developing human and bovine fetal ovaries., A significant correlation between ERalpha mRNA levels and PRL levels, tumor volume, TGFbeta1 mRNA levels in the total patient group were found., Monocytes from healthy controls and systemic lupus erythematosus patients, were studied to evaluate the production of TNF-alpha and TGF-beta in response to apoptotic cells., Activation of liver cells causes an increased synthesis of TGF-beta1 followed by a CTGF overproduction in various polymorphic hepatic structures, in accordance with the degree of fibrosis., Direct contact between tumor cells and human epithelial-like stem cells treated with DMBA increased integrin alpha V expression and caused local activation of the transforming growth factor (TGF)-beta1/Smad signaling pathways., Data indicate that expression of TGF-ss1 and TGF-ssR1 could be used as biological markers of bladder carcinoma., Caveolin 1 inhibits transforming growth factor-beta1 activity via inhibition of Smad signaling by hypertrophic scar derived fibroblasts in vi, interleukin (IL)-10, IL-17, transforming growth factor (TGF)-beta1, and interferon-gamma cytokines have an effect on expression levels of IL-10 and TGF-beta1 genes in renal allograft recipients after donor bone marrow cell infusion, prostate adenocarcinoma tumorigenesis requires a mix of -beta responsive and nonresponsive stromal cells and SDF-1, Sequencing the entire TGFBI gene revealed a heterozygous Arg124Leu (c.418 G ] T) mutation in all affected members confirming Reis-Buckler corneal dystrophy (GCD3)., Rsults suggest that dilatation in TAV and BAV patients has different alternative splicing fingerprints in the TGFbeta pathway., HA facilitates TGF-beta1-dependent fibroblast proliferation through promoting interaction between CD44 and EGFR, which then promotes specific MAPK/ERK activation, inducing cellular proliferation., results suggest that down-regulation of the expression of TGF-beta1, EGF and MMPs by hyperthermia probably accounts for the inhibition of the invasive abilities of MCF-7 cells, Mutation and polymorphisms of the TGFBI gene were detected in Chinese patients with keratoconus in this study. The results suggest that TGFBI gene might play an important role in the pathogenesis of keratoconus., five pedigrees and ten unrelated individuals diagnosed as corneal dystrophy were scanned for TGFB1 mutation by single-stranded conformation polymorphism, The chronic rhinosinusitis is characterized by elevated expression of TGF-beta1 compared to nasal polyposis., TGF-beta1 plays a key role in remodeling processes by contributing to the proliferation, migration and phenotypic modulation of adventitial fibroblasts and collagen composition and the mechanism may be related to both the Smad2 and Smad3 signaling pathways., polymorphism of TGF-beta1 -509C>T gene may modify individual susceptibility to infiltrating ductal breast carcinoma in Russian women of Western Siberian region., results indicate that TGF-betai is a vital trophic factor promoting islet survival, function, and regeneration; at least some of its beneficial effect was mediated by signaling through FAK, Thrombophlebitis accelerates activation of TGF-beta1 and activity of its receptor in the varicose vein wall., REVIEW, TGF-beta1-induced monocyte migration, requiring ALK5 kinase activity and signalling via PI3K and p38. TGF-beta1-driven monocyte motogenicity is fully functional in diabetic conditions., TGF-beta1 could induce epithelial to mesenchymal transition in squamous cell carcinoma of the head and neck cell lines, study demonstrate sa role for gastric epithelial cell-produced TGF-beta in the inhibition of CD4(+) T cell responses seen during Helicobacter pylori infection, The genotype at codon 10 in Transforming growth factor beta1 does not appear to influence the development of alcoholic liver cirrhosis., Transforming growth factor-beta activation is associated with peritoneal metastases in ovarian cancer, CK2 enhances the protein level and activity of TTP via the modulation of the MKP-1-p38 MAPK signaling pathway; TGF-beta1 enhances the activity of CK2, NF-kappaB downregulation of iNOS controls induction of EBV lytic cycle via TGF-b1., show herein that transforming growth factor (TGF)-beta induced a Smad3-dependent sustained stimulation of Egr2 gene expression in normal fibroblasts, The increased expression of VEGF and TGF-beta(1) in the context of hypoxia is closely related to the advanced oxidation protein products level in colon cancer SW480 cells., results suggest that genetic variations in the TGF-beta pathway are potential predictors of overall survival in NSCLC patients treated with platinum-based chemotherapy with or without radiation, sortilin negatively regulates TGF-beta signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway, overexpression of TIEG1 gene by a lentivirus transfection system led to suppressed human pancreatic cancer cell growth, Single Nucleotide Polymorphisms in TGF-beta signaling genes are associated with breast cancer susceptibility., CD109 release from the cell surface in human keratinocytes regulates TGF-beta receptor expression, TGF-beta signalling and STAT3 activation., dysregulated TGFbeta/SMAD4 signaling may lead to epigenetic silencing of a putative tumor suppressor, RunX1T1, during ovarian carcinogenesis, TGF-beta1-induced increase in PAR2 expression may be an elaborate mechanism that augments the progression of endometriosis., TGFbetaI was upregulated in MCF7 cells treated with chungkookjang., finite lifespan human mammary epithelial cells undergo a p16/RB- and p53-independent Oncogene-induced senescence in response to oncogenic RAS that requires TGF-beta signaling, TGF-beta(1) gene polymorphisms are not associated with an increased risk of chronic obstructive pulmonary disease in the Asian population., analysis of a novel TGFbeta/PKA tumor suppressor pathway that acts directly on a known cell survival mechanism that responds to stress with the survivin/XIAP dependent inhibition of caspases that effect apoptosis, gammadelta T cells function as Treg cells by their suppressive effect on the proliferation of autologous naive CD4(+) T cells. These regulatory gammadelta T cells (gammadelta Tregs) could be generated in vitro by stimulating with anti-TCRgammadelta in the presence of TGF-beta and IL-2., role of ADAMTS5 in dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor beta1 (TGFbeta1) signaling, Adenosine monophosphate-activated protein kinase (AMPK) inhibits TGF-beta-induced fibrogenic property of hepatic stellate cells by regulating transcriptional coactivator p300., Data show a decrease in the growth of fibroblasts and in the expression of ILGF-1 and TGF-beta messengers in keloid and nonkeloid fibroblast after chronic exposition to hyperbaric oxygenation compared with normal oxygen partial pressure., To investigate the relationship between TGFB1 +869T/C gene polymorphism and essential hypertension (EH), 5 studies with 2,708 subjects in the Chinese population on the relation between TGFB1 +869T/C gene polymorphism and EH were analyzed by meta-analysis, TTGF-beta 1/TT genotype was detected a gene of susceptibility to idiopathic thrombocytopenic purpura., these data suggest activation of TGF-beta signaling and suppression of BMP7 expression in the manifestation of oral submucous fibrosis., conclude that TGF-beta induces EBV lytic reactivation via the canonical Smad pathway by activating BZLF1 gene expression through multiple SBEs acting in concert, This study suggests that a polymorphism within the promoter of the TGFbeta1 gene is associated with increased radiation sensitivity (defined objectively by dose-dependent changes in SPECT lung perfusion)., CCN2 mRNA and protein was induced by strain, which caused Strain caused the rapid activation of latent TGFbeta., TGF-beta1 has a principal role at the initiation of endometrial carcinoma invasion through the promotion of the epithelial to mesenchymal transition., Long-term switch-like signaling responses in the TGF-b pathway might be critical for cell fate determination., The TC haplotype allele of TGFB1-509C/T and 868T/C polymorphisms may be associated with early-stage endometriosis in Korean women., In malignant cells with a functional TGF-beta signalling pathway Rac1 antagonizes the TGF-beta1 growth inhibitory response and enhances cell migration by antagonistically regulating Smad2 and Smad3 activation, study identifies a novel role for ICSBP in regulating cell growth via TGF-beta receptor upregulation and subsequent activation of the TGF-beta receptor/TAK-1/p38 pathway, Identification of global targets and molecular pathways and networks associated with TGFbeta1/SMAD3 signaling allow for a better understanding of the mechanisms that determine epithelial cell phenotypes in fibrogenesis and carcinogenesis, TGF-beta1 seems to be an additional regulator of donor engraftment., TGF-beta1 may both switch on and switch off MSF expression in a manner critically determined by the nature of the matrix substratum, mindin serves as a novel mediator that protects against cardiac hypertrophy and the transition to heart failure by blocking AKT/GSK3beta and TGF-beta1-Smad signalling., In the patients with Behcet's disease, there were significantly increased frequency of IL-2 (-330) GG genotype (p<0.001), IL-4 (-33) CC genotype (p<0.001), and TGF-beta (codon 10) CC genotype (p=0.004)., Snail and Zeb1 were sufficient to induce epithelial to mesenchymal transition (EMT) in the cells, but activated TGFbeta induced a more complex EMT, in which changes in extracellular matrix remodeling components were pronounced., role in the pathogenesis of non-segmental vitiligo related to the suppressive function of regulatory T cells, CCL5 and transforming growth factor-beta1 (TGFbeta1) have roles in breast cancer, down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4., TROP2 (TACSTD2), an EpCAM-like molecule, is a specific marker for TGF-beta1-dependent human epidermal Langerhans cells, C-509T and T869C gene polymorphisms in TGF-beta1 may be a critical risk factor of genetic susceptibility to cerebral infarction in the Chinese population., Osteoprotegerin promotes vascular fibrosis via a TGF-beta1 autocrine loop, FoxP1 is expressed by different cell types in atherosclerotic lesions and associated with more stable plaque characteristics and intraplaque TGFbeta signaling, Results confirm an association between TGF-beta1 polymorphisms and risk of acute myocardial infarction., results unveil a critical role for TGF-beta1 in the progression of mucoepidermoid carcinomas and suggest that patients with this malignancy may benefit from therapeutic inhibition of the effectors of the TGF-beta1 pathway., TGF-beta stimulated system xc-mediated cystine uptake in dental pulp cells and was protective against the toxicity of the glutathione synthesis inhibitor buthionine sulfoximine., TGF-beta1 may promote lung adenocarcinoma invasion and metastasis via the mechanism of epithelial-to-mesenchymal transition, Transforming growth factor beta1 may contribute to the invasiveness of pancreatic ductal adenocarcinoma by suppressing the conversion from CD24-positive cells to CD24-negative cells at the tumor site., In the absence of TGFBI, the knockdown mesothelial and mesothelioma cell lines exhibited an elevated proliferation rate., the development of osteoradionecrosis is related to the presence of the T variant allele at -509 within the TGF-beta1 gene., a dual pathway for TGF-beta1-induced transcription of miR143/145, thus revealing a novel mechanism underlying TGF-beta1-induced human vascular SMC differentiation., There is also an association between breast capsular contracture and the presence of homozygous G/G TGF-beta1 genotype., TGF-beta1 undergo a switch into mesenchymal cells and PI3K/Akt and MAPK/Erk1/2 signaling pathways serve to regulate TGF-beta1-induced epithelial-to-mesenchymal transition of A549 cells., Transforming growth factor beta (TGF-beta) has a crucial role in the differentiation of ectodermal cells to neural or epidermal precursors--REVIEW, The disease activity in chronic primary immune thrombocytopenia in pediatric patients is associated with reduced production of TGF-beta1, Combined strength and aerobic training increases transforming growth factor-beta1 in patients with type 2 diabetes., This meta-analysis suggests that the TGF-beta1 T869C polymorphism confers an elevated risk of diabetic neuropathy; significant associations were only observed in type 2 diabetic patients., Expression of TGFB1 in stromal cells of endometrial polyps is higher than in adjacent endometrium in proliferative and secretory phases; expression of TGFB1 in glandular cells of polyps is higher than in endometrium only in proliferative phase., Studies indicate that the mechanisms that regulate the retention of tissue-resident memory T cells include TGF-beta-mediated induction of CD103 and downregulation of CCR7., Data show that TGF-beta1 mRNA expression levels were significantly higher in normal bone marrow mononuclear cells but lower in leukemic cells., In Rheumatoid Arthritis patients, TGF-beta 869C/T Single nucleotide polymorphisms could influence the bone-erosive damage as evaluated by Musculoskeletal ultrasound, Potentially functional TGF-beta 1 T869C polymorphism may play a low penetrance role in chronic obstructive pulmonary disease susceptibility in an ethnicity-specific manner., The aim of this study was to evaluate regulatory T lymphocytes (Tregs) in the course of allergic contact dermatitis (ACD) and to elucidate the role of IL-10 and TGF-beta in Tregs activity., a direct role of NRP2 in epithelial-mesenchymal transition and highlight a cross-talk between neuropilin-2 and TGF-beta1 signaling to promote cancer progression, The biomechanical properties of alveolar epithelial cells (A549) following exposure to TGF-beta1., Histone deacetylase inhibitor belinostat represses survivin expression through reactivation of transforming growth factor beta (TGFbeta) receptor II leading to cancer cell death, Our study imply that T allele of TGF-beta1 -509 C/T genotypes may be a risk factor of genetic susceptibility to gastric cancer in south Indian population., TGF-beta1 expression in the vaginal margin had a close association with vaginal recurrence of stage Ib-IIa cervical squamous cell carcinoma and was an independent prognostic marker of this disease., study found an association of rs11327935 in COL1A1 with otosclerosis that was shown to be sex specific; the coding polymorphism T263I in TGFB1 was also associated with otosclerosis in the Tunisian population, The present finding that NF1/Smad4 repressor complexes are formed through TGF-beta signaling pathways suggests a new, but much broader, role for these complexes in the initiation or maintenance of the growth-inhibited state., TGF-beta1 gene has a well-established regulatory role in wound healing. The expression of TGF-beta1 was markedly induced by chemically or biologically synthesized plantaricin A., TGF-BETA1 down-modulates surface NKG2D expression by controlling the transcriptional and translational levels of DAP10., TGF-beta1-induced activation of Smad3 is the critical step for the uPA upregulation and E-cadherin downregulation, there was a significant correlation between Runx3 protein and TGF-beta(1) in patients with irritable bowel syndrome(P<0.05)., Thrombomodulin downregulation in vein grafts is mediated by paracrine release of TGF-beta1 caused by pressure-induced vessel stretch., [review] In this review, the authors discuss recent and ongoing research into the role of fibroblast growth factor and transforming growth factor-beta in the etiopathogenesis of craniosynostosis., Over expression of TGF-beta and CTLA-4 leads to T cell hyporesponsiveness, a major hallmark of leprosy, by increasing the expression of Cbl-b., TGF-beta1 has an opposite and dominant effect to IL-2. TGF-beta1 treatment decreases DAP10, as its presence inhibits the association of RNA polymerase II with the DAP10 promoter, but not NKG2D mRNA levels., The TbetaR-I pre-helix extension is structurally ordered in the unbound form and its flanking prolines are essential for binding., Tumor-secreted TGF-beta1 stimulates FHL2 protein expression in peritumoural fibroblasts, in sporadic colon cancer but not hereditary non-polyposis colorectal cancer., CRTC2 and calcineurin are critical signaling mediators in FSH and TGFbeta1-stimulated steroidogenesis in ovarian granulosa cells., raises a possibility that the higher frequency of TGFB1*29C allele and lower frequency of TGFBR1*6A allele may represent important genetic determinants that together contribute to a lower risk of breast cancer in western Indian women, The definition of the specific signaling downstream of TGF-beta regulating smooth muscle cell differentiation markers will contribute to a better understanding of vascular disorders involving changes in phenotype., TGFB1 variations show no association with the susceptibility of ankylosing spondylitis in Chinese Han population., Loss of interleukin-10 or transforming growth factor beta signaling in the human colon initiates a T-helper 1 response via distinct pathways., High transforming growth factor beta expression represents an important prognostic parameter for surgically resected non-small cell lung cancer., COMP and Col2a1 expression are regulated differently during chondrogenesis. COMP is a primary response gene of TGFbeta and its fast induction during chondrogenesis suggests that COMP is suitable for rapidly accessing the chondrogenic potential of stem cells, The authors have identified KLF6 as a key transcription factor required for trans-activation of TGF beta gene during human respiratory syncytial virus infection., Human dermal fibroblasts of T2D, compared to corresponding control values, displayed resistance to TGF-beta-mediated responses including cell migration, myofibroblast formation and p-Smad2 generation, Snail transcription factor plays a critical role in TGF-beta1-induced epithelial-mesenchymal transition in human retinal pigment epithelium cells., Data suggest that combination of HA, PIIINP, TGF-ss1 may provide a potential useful tool to assess liver fibrosis in adult HCV patients., TGF-beta1 expression is diminished in activated arteries and vascular cells which limits a protective role for this cytokine in the pathogenesis of arteriosclerosis., This short review summarizes recent knowledge about GLI2 function and mechanisms of action downstream of TGF-beta in cancer.[Review], TGF-beta1 CC genotype and C allele appeared as susceptible while TT genotype and T allele as protective for tobacco-related oral carcinoma in high-risk Asian Indians, EMT required DeltaNp63alpha transduction and intact TGF-beta signaling in normal human keratinocytes, Transforming growth factor beta1 T868C gene polymorphism is associated with cerebral infarction in patients with type 2 diabetes, analysis of pathogenic mutations of TGFBI and CHST6 genes in Chinese patients with Avellino, lattice, and macular corneal dystrophies, results suggest that MyD88 degradation driven by the Smad6-Smurf pathway is a novel mechanism for TGF-beta1-mediated negative regulation of MyD88-dependent pro-inflammatory signalling, CD109 is an important regulator of SMAD7/Smurf2-mediated degradation of TGFBR1., Demonstration of TGF-beta1 treatment induces bone marrow mesenchymal stem cells towards cardiomyogenic lineage, and therefore plays a role similar to that of 5-cytidine in the cardiac differentiation process., Chinese medicine constitutions were associated with TGF-beta1 (T869C) gene polymorphism, a potential predictor of susceptibility to diabetic nephropathy in type 2 diabetic mellitus patients., findings demonstrate that Akt is a downstream signalling component of TGF-beta-mediated biglycan core protein synthesis but not glycosaminoglycan chain hyperelongation in vascular smooth muscle, fascin expression significantly correlates with TGFbeta1 and TGFbeta receptor I levels in a cohort of primary breast tumor samples., A strong positive correlation between serum PDGF-BB and TGF-beta1 concentrations was found in patients with chronic pancreatitis., The higher expression of TGF-beta1 can protect articular cartilage by down-regulating the expression of MMP-9 of chondrocytes and synoviocytes in osteoarthritis., Androgen receptor transactivity is potentiated by TGF-beta1 through Smad3 but checked by its coactivator Hic-5/ARA55 in balding dermal papilla cells., Loss of Akt1 evokes epithelial-mesenchymal transition by autocrine regulation of transforming growth factor-beta1., CYLD regulates TGF-beta signaling function in T cells and the development of Tregs through deubiquitination of Smad7, BMP-7 may exert anti-invasive actions by inhibiting TGF-beta-induced expression of integrin beta(3)., There was an upregulation in the TGFbeta pathway in patients with thoracic aortic aneurysm/dissection., Ultrasound irradiation promotes alpha-SMA and TGF-beta1 expression in human dermal fibroblasts., Study conclude that TGF-beta1 binds to COMP and that TGF-beta1 bound to COMP has enhanced bioactivity., Marfan patients may have aberrant TGF-beta signaling pathway associated with increased collagen deposition, interlamilar elastic fiber degenerative changes, and acid mucopolysaccharide accumulation., CD105 protein depletion enhances human adipose-derived stromal cell osteogenesis through reduction of transforming growth factor beta1 (TGF-beta1) signaling., TGF-beta-induced TG2 enhances ovarian tumor metastasis by inducing epithelial-to-mesenchymal transition and a cancer stem cell phenotype., There is a significant increase of protein kinase C epsilon expression in CD4 T cells from Hashimoto thyroiditis patients accounting for enhanced cellular survival, proliferation, and decreased sensitivity to TGF-1beta., The present study focused on TGF-beta-modulation of paxillin and the serine/threonine protein phosphatase PP-1, and the impact on cellular motility., It was shown that miR-146a functions as a novel negative regulator to modulate myofibroblast transdifferentiation during TGF-beta1 induction by targeting SMAD4., TGF-beta1 promotes overexpression of A20 through tyrosine phosphatase activity that ensures transient activation of inflammatory signaling pathways in macrophages in active L. donovani infection., the protein associates with TGF-beta receptors and components of the TRAF6-TAK1 signaling module, vascular phenotype with regard to VEGFR2 expression and TGF-beta signaling in endothelial cells varies with malignancy in human glioma., This work identifies miR-744-directed post-transcriptional regulation of TGF-beta1., BMP-2 had a similar binding affinity for each extracellular matrix, while TGF-beta1 had a greater affinity for ECMs produced by osteoblasts from control compared to craniosynostosis patients, The present study was the first to demonstrate a clear relationship between the Arg25Pro polymorphism and quality of life acute toxicity in neoadjuvant radiochemotherapy, These findings demonstrate a prominent role of TGFbeta-signaling in recessive dystrophic epidermolysis bullosa-related skin cancer., TGF-beta(1)-induced perlecan deposition may enhance attachment of migrating airway smooth muscle cells (ASMC) in vivo and thus may be a mechanism for ASMC layer hypertrophy in chronic obstructive pulmonary disease, High glucose together with mannose binding lectin can up regulate the expression of TGF-beta1 and the activity of NF-kappaB in renal glomerular endothelial cells., TGF-beta activation is triggered by increasing urokinase plasminogen activator (uPA)receptor-dependent uPA activity, thus initiating and amplifying a cascade of events that promotes myofibroblast transdifferentiation and scar., mediates macrophage regulation by Treg cells in deciduas, These data highlight a mechanism of TGF-beta activation in asthma, a global view of the impact of Snail and Slug expression, Codon 10 of TGF-beta 1 might be a risk factor for cerebral small vessel disease , specifically in ischaemic leukoaraiosis phenotype., Report development of TGFB1 short interfering RNAs for treatment of pulmonary fibrosis., we provide evidences that induction of TGF-B1 production and Smad3 phosphorylation by Ox-LDL is mediated by Ras/ERK/PLTP pathway in human alveolar epithelial cells., Study reports that master transcription factors also are responsible for directing the gene targets of TGF-beta signaling and thus determine the cell-type-specific effects of TGF-beta signaling., deltaEF1 family proteins repress the expression of ESRPs to regulate alternative splicing during TGF-beta-induced EMT and the progression of breast cancers, Pten-deficient mice developed full-penetrance HNSCC in combination with type I TGF-beta receptor (Tgfbr1) deletion, mp53 disrupts the role of ShcA in balancing the Smad-dependent and -independent signaling activity of TGF-beta and ShcA/ERK signaling is a major pathway regulating the tumor-promoting activity of TGF-beta, Wnt/beta-catenin pathway forms a negative feedback loop during TGF-beta1 induced human normal skin fibroblast-to-myofibroblast transition, TGF-beta1-509C/T polymorphisms were associated with a better response to radiochemotherapy for esophageal squamous cell carcinoma., The expressions of TGF-beta 1 and COX-2 in the peripheral blood were elevated in prostate cancer patients., Five SNPs (rs1800469, rs2241712, rs2070874, rs20541 and rs1800925) in TGF-beta1, IL-4 and IL-13 were genotyped using the MassArray SNP genotyping system., increases vaginal tropoelastin production in vaginal smooth muscle cells, This study demonstrates significantly reduced serum levels of both total and active TGF-b1 in women with systemic lupus erythematosus compared with healthy women, TGFbeta1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis., Transforming growth factor B1 polymorphisms are not associated with gastric cancer., After adjustment of confounding factors, GSTP1 Ile105Val, GSTA1 C-69T, and TGFbeta1 T869C polymorphisms were found to be significantly associated with the risk of Grade 2-3 radiation-induced fibrosis., Inducible antigen-specific LAP+ regulatory T cells can suppress asthmatic lung inflammation and constitute a mediator of airway tolerance together with Foxp3+ Tregs., Hexim-1 protein expression and cellular distribution significantly influence TGF-beta-dependent downstream SMAD transcription factor signaling in prostate cancer progression., Expression of TGF-beta1 was significantly correlated with the risk of lymph node involvement, disease recurrence and shorter survival in patients with pathological stage III-IV oral cancer., IL-7 and TGFbeta1 are promising markers to indicate those at risk for poor prostate cancer survival., These results suggest that Erbin is a negative feedback molecule induced by TGF-beta1 and inhibits TGF-beta1-induced epithelial-to-mesenchymal transition via ERK signaling pathway., The expression of TGF-beta1 in peripheral blood mononuclear cells is significantly elevated in patients with chronic fatigue syndrome. It might be correlated to the pathogenesis of the disease., TGF-beta(1) promotes transdifferentiation of of fibroblasts into myofibroblasts in the skin lesion of systemic sclerosis., TGFB1 induces either chondrogenic or smooth muscle cell differentiation of bone marrow mesenchymal stem cells in vitro; TGFB1 inhibits adipogenic differentiation of bone marrow mesenchymal stem cells in vitro. [REVIEW], Concentrations of the vasoactive factors sEng in serum and TGF-beta(1) in plasma are significantly altered in subarachnoid hemorrhage patients., Genetic variants in ABCB1, TGFB1, and XRCC1 appear to be associated with susceptibility to hepatitis A virus infection among Mexican Americans., Expression of Lewis y antigen and TGF-beta1 was significantly positively associated with epithelial carcinoma. Close correlation between Lewis y, TGF-beta1 and ovarian cancer was observed., Polymorphisms of the TGF-beta1 gene do not influence the susceptibility to or clinical parameters of inflammatory bowel disease in children., Overexpression of Evi1 oncoprotein is identified as a novel mechanism by which a subset of human human colorectal cancer cells may escape TGF-beta regulation., Force-induced latency-associated peptide conformational changes result in transforming growth factor (TGF)-beta1 release. Mechanical pulling opens the straitjacket structure that keeps TGF-beta1 latent., children with severe asthma have increased airway TGF-beta1 expression and activation associated with an increased airway oxidant burden; oxidant stress might mediate the effects of TGF-beta1 and promote airway remodeling in children with severe asthma, The meta-analysis indicated the significant association of +869T/C, but not +915G/C polymorphism with hypertension susceptibility., Diabetic nephropathy is a major diabetic complication that is mediated by transforming growth factor-beta1 via Smad-dependent and -independent signalling pathways--{REVIEW}, High serum transforming Growth Factor beta is associated with virus infection in liver carcinogenesis., TGFb1 expression increases in lung fibroblasts treated with silicon dioxide., Data suggest that TGFbeta1 induces epithelial-to-mesenchymal transition and instigates a loss of E-cadherin, cell adhesion and connexin-43 mediated cell communication in the proximal tubule under diabetic conditions., ERK-dependent production of TGF-beta1 plays a crucial role in the soy peptide-induced proliferation of adipose tissue-derived mesenchymal stem cells under serum-free conditions., mediates epithelial-to-mesenchymal transition in lung epithelium induced by oxidative stress, Man-6-P-dependent effects on latent TGF-beta1 activation are not mediated by direct modification of its latency-associated peptide., TGF-beta1-mediated repression through decreased hepatocyte nuclear factor binding to its cognate promoter element, conclude that, in human pulmonary fibroblasts, TGF-beta acts on ryanodine-sensitive channels, leading to Ca(2+) wave activity, which in turn amplifies extracellular matrix gene expression, results suggests that the androgens deprivation by means of ADT for 1-month, involves a shift of the TGF-beta1 mechanism in prostate cancer, suggesting that the TGF-beta1 promotes prostate epithelial cell proliferation, TGF-beta(1) is overexpressed in invasive types of hepatocellular carcinoma (HCC) and it may be involved in the rapid progression of HCC, menin mutant exhibits selective loss of the TGF-beta signaling pathway and loss of cell proliferation control contributing to the development of MEN1., Data suggest that TGF-beta, TGF-betaR1, TGF-betaR2, Smad4, pSmad2/3, and E-cadherin are closely related to tumor-node-metastasis (TNM) stage of colorectal cancer (CRC)., Study shows that TGFbeta can also be activated from the GARP-proTGFbeta1 complex by alphaVbeta6 and alphaVbeta8 integrins., This study characterizes the role of integrin alphaVbeta8-TGFbeta signaling in murine retinal vascular development., In Chinese patients, the -509C/T polymorphism in TGFbeta1 may play a vital role in mediating individual susceptibility to NPC., Studies indicate TGF-beta1 is a pleiotropic cytokine, which plays a central role in the development, homeostasis and responses of the immune system., TGF-beta1 is proangiogenic in vivo and induces endothelial progenitor cells angiogenic properties in vitro, suggesting that TGF-beta1 may play a role during vascular remodeling in fibrotic disease states via EPCs., Findings suggest that TGFbeta and IL-13 play a synergistic role in the pathogenesis of fistulae in Crohn's disease., T869C polymorphism of the TGF-beta1 gene has an impact on decreased serum TGF-beta1 levels and influences susceptibility to osteopenia/osteoporosis in Thai women., the rs1805110T allele is associated with susceptibility to HBV-related hepatocellular carcinoma in males, results indicate that TGFbeta1- and growth factor-mediated signalling activities mediate TM4SF5 expression leading to acquisition of mesenchymal cell features, suggesting that TM4SF5 induction may be involved in the development of liver pathologies, generation of TGF-beta and BMP receptor homo- and hetero-oligomers and its roles as a mechanism capable of fast regulation of signaling by these crucial cytokines [review], Cripto/GRP78 modulates the TGF-beta pathway in development and oncogenesis [review], demonstrate a requirement for ILK function in TGFbeta-1-induced EMT in mammary epithelial cells and identify the ILK/Rictor complex as a potential molecular target for preventing/reversing EMT, characterization of the expression and biochemical properties of EMILIN-3, data suggest a role for TGF-beta1 and anti-inflammatory macrophages in malignant transformation of intestinal epithelial cells, involving upregulation of L1CAM expression by which epithelial cells acquire an apoptosis-resistant and migratory phenotype, High expression of the IFN-gamma gene may carry a higher risk for acute rheumatic fever in Turkish children, while IL-6, TNF-alpha, and TGF-beta1 may have an impact in mediating some clinical and laboratory manifestations of the disease., These findings suggest that ursolic acid inhibits cell growth via causing apoptosis in U251 cells by a ursolic acid-triggered TGF-beta1/miR-21/PDCD4 pathway., Blood flow shear stress activates TGF-beta-Alk5 signaling in endothelial cells, which is necessary for Endothelial-to-mesenchymal transition in the underlying endocardial cushion matrix during embryonic heart valve development., autocrine TGF-beta signaling is an integral part of the cellular anti-transformation network by suppressing the expression of a host of genes, including p21-regulated genes, that mediate oncogene-induced transformation in basal-like breast cancer., Genetic variants of TGF-beta1 at codon 25 may have an impact on kidney function, suggesting an unfavorable effect of C allele in pretransplant setting and serve as marker for the recovery of renal function after liver transplantation., This review describes how MITF transcription factor regulates melanogenesis by activation of tyrosinase, TRP1 and TRP2 transcription. It also affects expression of other factors regulating melanosome maturation, biogenesis and transport., Lysophosphatidic acid induces TGFBI expression by stimulating secretion of TGF-beta 1., COM stimulates the expression of MCP-1 and TGFbeta1 in renal epithelial cells., We now demonstrate that TGFbeta induces SIK1 levels via a direct transcriptional mechanism that implicates the Smad proteins., TGF-beta downregulated several miRNAs in both normal fibroblasts & systemic sclerosis fibroblasts. Exogenous TGF-b stimulation upregulated type I collagen expression via miR-196a downregulation in normal fibroblasts., were able to exclude up to a 2-fold increase in the risk of developing late gastrointestinal and genitourinary radio-induced toxicity due to the TGFbeta1 SNPs rs1800469 and rs1800470, as well as the two most frequent TGFbeta1 haplotypes, PD-L1 expression in monocytes is regulated by opposing actions of TNF-alpha and TGF-beta. As PD-L1 functions to fine tune lymphocyte activation, dysregulation of cytokines resulting in reduced expression could lead to loss of peripheral T cell tolerance, Induction in vivo also correlated with Smad signaling by activated TGFbeta1 after IR., PAK2 negatively modulate TGF-beta signaling by attenuating the receptor-Smad interaction and thus Smad activation, Reelin is an essential negative regulator in the TGF-beta1-induced cell migration process, and is suppressed by TGF-beta pathway at the transcriptional level through Snail regulation, TGF-beta1 has a crucial role in periodontal disease fibrogenesis by intensifying the action of CTGF, Studies indicate that transforming growth factor-beta1 TGF-beta1-509 C > T and 800 G > A might contribute to the increased risk of colorectal tumor (CRC), and could be used as two of genetic marks for screening individuals at high risk of CRC., Study results highlight the crucial roles of TGF-beta and IL-4 in the regulation of prostaglandin production, which suggests that T cells play an important role in follicular dendritic cell production of prostaglandins., Expression of transforming growth factor beta-1 in the resected left atrial appendage affects the recurrence of atrial fibrillation and restoration of functional left atrial contraction after the radiofrequency modified maze procedure., We will introduce several genetic approaches, which have been or are currently being applied to the study of PDA, that have been successful in identifying polymorphisms associated with adult diseases, findings demonstrate that canonical Wnt signalling is necessary for TGF-beta-mediated fibrosis and highlight a key role for the interaction of both pathways in the pathogenesis of fibrotic diseases, silenced TGF-beta1 generated a stronger Th1/Tc1 immune response to the respective wild-type ovarian carcinomas (OvC) and also to the OvC antigens mesothelin and HE4, In the total group of subjects with acute ischemic stroke, blood levels of TGF-beta are significantly elevated at day 1 following stroke., A correlation (p = 0.0251) between TGF-beta and caspase-3 in the lepromatous leprosy was found., findings suggest a novel role for the steady state intracellular ROS concentration, where the compartmentalized, different systems involved in the intracellular ROS production, could be essential for the expression of AP1-dependent genes, as TGF-beta1, TGF-beta signalling reduces the expression of ALDH1 and REG4, and the size of the ALDH1+ cell population., one SNPs showed significant associations with CRAD development, Alterations in extracellular matrix composition, such as high levels of the TGF-beta storage protein LTBP-1 and the re-appearance of fibrillin-2, probably modulate TGF-beta availability and activation in different pulmonary compartments in the fibrotic lung., Strong FAPalpha and TGF-beta1 expressions were detected in myocardial cytoplasm in both acute and recurrent myocardial infarction groups., study concludes that TGF-beta1 could induce apoptosis of mesothelial cells, which involves the smad2 signaling pathway in peritoneal carcinomatosis, Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor beta1 (TGF-beta1) in epithelial cell lines, chelators inhibit the TGF-beta-induced EMT via a process consistent with NDRG1 up-regulation and elucidates the mechanism of their activity., Data suggest that the formation of transient TIF1gamma-Smad2-Smad4 ternary complexes is the only one that can account for TGF-beta signaling., The aim of the study was to determine temporal TGFB1, TGFB2 and TGFB3 gene expression profiles in the anterior lens capsule of paediatric patients with posttraumatic cataract., results suggest that TGF-beta1 T29C gene polymorphism could be involved in the risk of developing ACS in Mexican individuals, Decreased soluble TGF-beta1, Tie-2, and angiopoietins serum levels in bone marrow after treating healthy donors with granulocyte colony-stimulating factor., TGFbeta1 has endogenous anti-progestational effects in stromal cells and the opposing effects of progesterone and TGFbeta1 are important in regulation of matrix integrity in human endometrium., Data show that granzyme B (GrB) liberated TGF-beta1 from substrates decorin, biglycan and betaglycan., There is efficient and reproducible induction of SZP/lubricin accumulation by TGF-beta1 and BMP-7 in skeletal muscle-derived mesenchymal stem cells., CYLD negatively regulates TGFb1 signalling via deubiquitinating Akt., determined that TGF-beta rapidly repressed protein kinase A activity, thus reducing both phospho-cAMP-response element-binding protein (CREB) levels and CREB-dependent transcription of the M-MITF promoter, promoter region polymorphism is not associated with preeclampsia, but serum concentrations are higher in preeclamptic Iranian women, Tested feasibility of using bioprinting for cartilage engineering. Bioprinted samples treated with FGF-2/TGF-beta1 had the best chondrogenic properties among all groups., The level of MMP-2 activation was significantly elevated in tissues with Dupuytren's contracture. RT-PCR demonstrated significantly higher expression of MMP-2, TIMP-2, TGF-beta1, and DCN mRNA in the pathological tissues, Interaction between smoking and single nucleotide polymorphisms in TGFB1 gene is associated with ischemic heart disease and myocardial infarction in rheumatoid arthritis patients., TGF-beta1, CTGF, collagen I and collagen III were upregulated in sarcoiliac joints of ankylosing spondylitis patients., autocrine TGF-beta signalling in certain breast cancers promotes cell survival via inhibition of apoptotic signalling, Dysregulation of the TGF-beta1/Smad pathway may predispose the pathogenesis of aortic disorders., Association of single nucleotide polymorphisms in the genes ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with risk of severe erythema after breast conserving radiotherapy., Tissue expression of TGF-beta1 is increased in cervical samples from HIV-infected women with cervical intraepithelial neoplasia., The expression changes of TGF-beta1 and E-cadherin may be related to the emergence and the development of glioma., findings suggest that CD44s plays a critical role in the TGF-beta-mediated mesenchymal phenotype and therefore represents a potential therapeutic target for HCC, SNP rs8110090 in TGFbeta1 was significantly associated with both the primary scar outcome and the secondary scar outcome following melanoma excision, N-linked glycosylation is essentially required for the successful cell surface transportation of TGFbetaRII, suggesting a novel mechanism by which the TGF-beta sensitivity can be regulated by N-linked glycosylation levels of TGFbetaRII., Persistence of TGF-beta1 inhibited osteoblast differentiation via suppression of IGF-1 expression and subsequent down-regulation of the PI3K/Akt pathway., TGF-beta1 can augment eosinophilic inflammation by interfering with IL-13's negative feedback autoregulatory loop under MEK/ERK-dependent conditions, These studies show that TSP1 regulated TGF-beta activity is a critical determinant of osteoblast differentiation., The TGF-beta1 mRNA level, but not the amount of the gene product, was significantly increased in the pathologically changed tissue during the relapse of inflammatory bowel diseases., data demonstrate that the C-509T genotype has no effect on the cellular radiosensitivity, TGFB1 protein secretion, or TGFB1 expression of peripheral blood lymphocytes or fibroblasts., locally produced TGF-beta1 by prostate cancer cells induces a proinflammatory and pro-oxidant milieu in TGF-beta1 hyperresponsive stromal cells, leading to up-regulation of Cox-2., Mutations in the transforming growth factor-beta are unlikely to disrupt protein folding or induce endoplasmic reticulum stress., An association was shown between rs1800469 and rs1982073 in the TGFB1 gene and the risk of coronary heart disease in Caucasian populations., analysis of the crosstalk between TGF-beta and hedgehog signaling in cancer [review], conclude that stromal cells exert inhibitory as well as stimulatory effects on tumor cells; TGFbetaig-h3 is a stromal inhibitory factor that is decreased with progression of gastric cancers, TGFbeta1 gene Leu10Pro variation in signal peptide has significant effects on TGFbeta1 secretion and functions in hepatic cells., TGF-beta induces the formation of complexes comprising phosphorylated Smad1/5 and Smad3, which bind to BMP-responsive elements in vitro and in vivo and mediate TGF-beta-induced transcriptional repression., TGF-beta family signaling through Smads is conceptually a simple and linear signaling pathway, driven by sequential phosphorylation, with type II receptors activating type I receptors, which in turn activate R-Smads [review], The kidney takes part in the elimination of IL-6 and PDGF from systemic circulation. The kidney does not take part in the elimination of TGF-beta., Elevated baseline PIIINP concentration is an independent predictor for AF recurrence after cardioversion. Furthermore, there is a relationship between PIIINP and RMS20 and the fibrosis of AF., genetic association studies, km23-1 is required for TGFbeta1 autoinduction through Smad2-independent Ras/ERK/JNK pathways, analysis of matrix-dependent perturbation of TGFbeta signaling and disease [review], TGF-beta and RELA activation promoted SMAD7 expression. In turn, SMAD7 preferentially suppressed TGF-beta-induced SMAD and NF-kappaB reporters when compared with constitutive or TNF-alpha-induced NF-kappaB reporter gene activation, TGF-beta1 treatment of MCF-7 cells significantly reduced JAM-A mRNA & protein via SMAD activation, & induced cell invasion., analysis of evolution of the TGF-beta superfamily and how they signal through a single pair of receptors, known as TbetaR-I and TbetaR-II [review], serum TGF-Beta1 level in HCC patients is directly correlated with metastasis and recurrence of tumors and increases gradually with the progression of hepatocellular carcinoma in HCV infected patients, the current study indicates that TGFb1, a mediator of inflammation, is 1 of the many factors involved in the pathogenesis of radiation-induced nocturia., high glucose-induced TGF-beta1 gene transcription occurred through Pak2, Syk and subsequent ERK/AP-1 and NF-kappaB pathways, The previously described disease association of TGFB genetic variant rs1800471 and tendency toward significance of genetic variant rs1800470 could not be replicated in the Japanese cohort., A meta-analysis suggests that common genetic polymorphisms in TGF-beta1 are associated with complications of coronary heart disease., The number of tumor-asssociated microglia/macrophages at the invasive cell front correlates with the presence of CD133-positive glioma stem-like cells, which produce high levels of TGF-beta1., TGF-beta1, MMP-9 and TIMP-1 may play a role in the tissue remodeling process in allergic rhinitis., Among the 37 patients who had received chemoradiotherapy, TGFbeta1 genotype was associated with disease-free (HR = 0.44, 95% CI 0.19-1.02) and overall survival (HR = 0.31, 95% CI 0.12-0.80) independent of tumor p16 expression., when the SNON-SMAD4 complex is absent as in some cancer cells lacking SMAD4 the regulation of some TGF-beta target genes is modified, This study indicated that TGF-beta1-509 C>T polymorphism was probably associated with risk of DTC, especially for Caucasians., Transforming growth factor-beta1 (TGF-beta1) plays a key role in the tissue remodeling processes involved in chronic rhinosinusitis., Data indicate that TGF-beta1-509 and TNF-alpha-308 genes polymorphisms are associated with risk of liver cirrhosis and hepatocellular carcinoma (HCC) in patients with chronic hepatitis C virus (HCV) infection infection., TGF-beta signaling has a role in nuclear localization of transcription factor Smad4, The findings presented here highlight that biomarkers, such as TGF-beta1 and VEGF, play a key role in the evolution of the immune response, which in turn influences the outcome of disease establishment., The upregulation of CD109 protein in SSc may represent an adaptation or consequence of aberrant TGF-beta signaling in systemic sclerosis, TGFBI plays a suppressive role in the development of mesothelioma and breast cancer cells, possibly through inhibitions of cell proliferation, delaying of G1-S phase transition, and induction of senescence., TGF-beta1 is an important factor participating in the disc degeneration and its expression level is closely related to the pathological grade of degenerative discs., findings illustrate that an autocrine loop of VEGFA via VEGFR-2 is critical for the tumorigenic effects of TGF-beta1 and hypoxia on metastatic prostate cancers, TGF-beta1 isoform is a key agent in seminal plasma that signals induction of proinflammatory cytokine synthesis in cervical cells., Expression of SKI caused resistance to TGF-beta-mediated suppression of IL-2, but SMAD2 phosphorylation was unaffected, analysis of the dynamics of TGF-beta and Smad2/Smad3 signaling [review], analysis of regulation of TGF-beta signal transduction by mono- and deubiquitylation of Smad [review], analysis of TGF-beta control of stem cell differentiation genes [review], analysis of regulation of EMT by TGFbeta in cancer [Review], This meta-analysis indicated that TGF beta1-509C/T rather than +869T/C is a potential risk factor for UDT cancer., Complement fragment C3f could reduce the formation of TGF-beta1 and type I, III collagens in MRC-5 cells, and inhibit lung tissue fibrosis., Data suggest higher cord blood TGF-alpha and TGF-beta1 concentrations may represent a compensatory response to the inflammatory process characterizing the intrauterine-growth-restricted (IUGR) state., TGF-beta1 contributes to HCC-induced vascular alterations by affecting the interaction between HCC-StCs and Ld-MECs through a down-modulation of NCAM expression, TGF-beta1 and its receptors including TGF-betaRI and TGF-betaRII are abnormally expressed in the peripheral blood of immune thrombocytopenic purpura patients., We demonstrated in dermal fibroblasts that VEGF was overexpressed due to autocrine TGF-beta/Smad signaling in scleroderma., findings suggest that miR-23a regulates TGF-beta-induced epithelial-mesenchymal transition by targeting E-cadherin in lung cancer cells, Ablation of TGF-beta signaling in T cells does not confer resistance in transgenic mice to Heligmosomoides polygyrus infection., study demonstrates that paracrine transforming growth factor-beta1 secreted by adipose-derived mesenchymal stem cells regulated the establishment of epithelial-mesenchymal transition in MCF7 cells by targeting the ZEB/miR-200 regulatory loop, Vessel-associated TGF-beta1 activity is increased in the bronchial Rbm in smokers and especially those with chronic obstructive pulmonary disease., TGF-beta1 increases cell rigidity by enhancing expression of smooth muscle actin; keloid-derived fibroblasts are a model for cellular mechanics, Transforming growth factor-beta1 markedly enhanced tissue factor expression in primary human lung fibroblasts., USP11 augments TGFbeta signalling by deubiquitylating ALK5., neurogenesis is promoted by an interplay between the TGFbeta pathway, Smad3, and the H3K27me3 histone demethylase (HDM) JMJD3, our findings indicate that alphavbeta6 and TGF-beta act in a common tumor suppressor pathway, TGFbeta1 may take part in the increase of cellular production of collagen type I and apoptosis during the development of tendinopathy., These results suggest that eltrombopag can partially modulate some immune responses by TGFbeta(1) and sCTLA-4, but it does not induce immune tolerance by 24 weeks after treatment., The recent discovery of TGFbeta signaling involvement in acromelic dysplasias, is discussed., we demonstrate a novel mechanism by which non-invasive primary prostate tumor cells transition to an invasive phenotype characteristic of malignant tumor cells in response to TGF-beta signaling., several polymorphisms detected in the TGFbeta1 gene and its receptor associated with benign and malignant breast tumors, association between genetic variants and keloids in the Malay population., These results suggest a pivotal role for lipid raft-associated ADAM12 in the TGF-beta1-induced differentiation of human adipose tissue-derived mesenchymal stem cells into smooth muscle cells., increased serum levels correlate with symptom improvement after specific immunotherapy in patients with allergic rhinitis, Impairment of autophagy by TGF-beta(1) may represent a mechanism for the promotion of fibrogenesis in idiopathic pulmonary fibrosis, no correlation between SARA expression and the levels of TGF-beta1-induced phosphorylation of Smads in various B-cell lymphomas, study identified a novel role of TGFbeta in the control of LPA1 expression and LPA1-coupled biological functions, adding LPA1 to the list of TGFbeta-repressed target genes, an association between TGF-beta1 (codon 10) T/C polymorphisms and suicide behavior., Ets-1 has an inhibitory role for COL1A2 transcription participates in the negative contribution of Ets-1 in TGFbeta1/Smad3-activated renal cells, a strong TGF-beta1 expression was significantly associated with poor survival only when the endoglin MVD value was higher than 10., discusses how TGF-beta signaling in relevant cell types (tubular epithelium, fibroblasts) contributes to tubulointerstitial fibrosis progression; suggests ways future research can improve understanding of TGF-beta-mediated tubulointerstitial fibrosis [review], TGF-beta/Smad signaling plays a critical role in renal fibrosis and inflammation in chronic kidney disease. [Review Article], review focuses on current insights into the mechanism and function of the Smad-independent signaling pathway via TGF-beta-activated kinase 1 and its role in mediating the profibrotic effects of TGF-beta1 in chronic kidney disease. [Review Article], This review covers the recent studies on the roles of miRNAs and miRNA circuits in transforming growth factor-beta actions and in diabetic nephropathy [review], By enhancing TGF-beta signaling, increased dietary salt intake leads to progressive renal failure from nephron loss and glomerular and tubulointerstitial fibrosis., MTA1 appears to regulate a key inhibitor of TGFbeta signalling, SMAD7. By regulating molecules like SMAD7 MTA1 might assist the process of tumourigenesis and metastasis., Transcriptional regulation of TGF-beta1 by GLI2 is a new extension to Sonic Hedgehog and TGF-beta1 cross-regulation., Cancer cell-derived TGF-beta1 induces the metabolic reprogramming of fibroblasts, with increased autophagy, glycolysis and caveolin-1 downregulation., Higher levels of plasma TGF-B1 were associated with an increased risk of incident heart failure among older adults., findings indicate that CLU is an important mediator of TGF-beta-induced EMT, and suggest that CLU suppression may represent a promising therapeutic option for suppressing prostate cancer metastatic progression, TGFB1 is upregulated after the release of ureteropelvic junction obstruction. Locally increased TGF-beta-1 in the postobstructed kidney may cause downregulation of AQP1., identified polymorphic markers in TNFalpha, IL10, IL1beta and TGFbeta1 genes to be associated with alcoholic liver disease in the Bengali population, TGF-beta induces serous borderline ovarian tumor cell invasion by activating EMT but triggers apoptosis in low-grade serous ovarian carcinoma cells, Data indicate that circulating substance P (SP) and TGF-beta1 levels are increased in patients with myelofibrosis., In this Chinese family an R555Q mutation of the TGFBI gene was associated with RBCD, These results indicate that miR-K10 variants of Kaposi's sarcoma-associated herpesvirus manipulate the TGF-beta pathway to confer cells with resistance to the growth-inhibitory effect of TGF-beta., TGFbeta signaling together with intrinsic disturbances in neurofibromatosis type 2 (NF2) and Hippo signaling cascades in malignant mesothelioma cells converges upon further expression of connective tissue growth factor., documented an increase in TGF-beta ligands and an absence of TGF-beta receptor II in malignant peripheral nerve sheath tumors, which correspond to tumors in the Nf1-deficient mouse model, increased TGF-beta expression during diabetes may be a feasible pathogenic mechanism underlying poor bone formation in uncontrolled diabetes mellitus, The results of this study indicate that polymorphisms and the haplotypes in the TGFbeta1 gene might be genetic markers for CI in the Chinese population., Suggest that TGFbeta1/Smad2 signalling pathway of T cells is altered in patients with Behcet's disease., This study investigates cytokine expression and proteomic change induced by SARS-CoV PLpro in human promonocyte cells. PLpro significantly increased TGF-beta1 mRNA expression (greater than fourfold) and protein production (greater than threefold)., Endoglin-mediated fibronectin/alpha5beta1 integrin and TGF-beta1 pathway crosstalk switched the respone to TGF-beta1 from a promoter to a suppressor of migration, inhibiting TGF-beta1-mediated apoptosis, and partially mediating developmental angiogenesis in vivo., The TGF-beta T869C polymorphism and its expression correlated with CXCR4 expression in breast cancer patients., TGF-beta1 can induce epithelial-to-mesenchymal transition through reduction in SARA expression, SARA is also basally regulated by its interaction with PI3K., TGF-beta1-induced ATP release in cell migration is, in part, mediated through activation of P2X7 receptors., Telmisartan attenuated TGF-beta1 induced epithelial-to-mesenchymal transition by agonistic activation of PPAR-gamma., Recombinant TGFbeta1 effectively blocks recombinant BMP-2 and BMP-7 signaling in osteoblasts., GSK3beta chemical inhibition results in HNF4alpha DNA binding impairment while a constitutively active GSK3beta mutant impairs the TGFbeta-induced inhibitory effect on HNF4alpha tumor suppressor activity., The study reveals involvement of the TGF-beta inducible p38 MAPK pathway as a possible signalling cascade in the pathogenesis of Dupuytren's disease., TGFbeta and its downstream mediator Smad3 were both identfied as contributors to medulloblastoma metastasis and survival., results suggest that endogenous TGF-beta contributes to a suppressed IFN response to RV infection possibly via SOCS-1 and SOCS-3, TSP-1 and TGF-beta1 may play important roles in the progression of prolactinoma, by affecting angiogenesis., Decreased levels of interleukin (IL)-17 and IL-17/TGF-beta ratio are found in first-episode psychosis patients who are drug-naive, suggesting new aspects of schizophrenia pathophysiology., findings suggest that HBV infection and activity of the TGF-beta-miR-34a-CCL22 axis serve as potent etiological factors to predispose hepatocellular carcinoma patients for the development of portal vein tumor thrombus, The proteasome inhibitor MG132 could inhibit IL-6/TGF-beta-mediated downregulation of FOXP3 protein, which reveals a potential pathway for modulating Treg activity., Transgenic TGF-beta negatively regulates the accumulation and effector function of transferred self/tumor-specific CD8 T cells, potentially hampering the success of adoptive T cell therapy for solid tumors., A dual role is supported for TGF-beta and transgenic forkhead box (Fox)p3 protein in induced tolerance, in which TGF-beta stimulates Foxp3 expression, for which sustained expression is then associated with acquisition of tolerance., TGF-B1-509(*) T-carrying genotypes were more frequent in pancreatic carcinoma patients with severe post-operative complications., Data indicate that TGF-beta blockade significantly decreased tumor growth and metastasis in xenograft model., the present study revealed a significant association of 509 C/T polymorphism genotype of TGF beta1 with breast cancer in South Indian population from Andhra Pradesh, Global reduction of both forms of p53 led to an enhanced EMT response to TGFbeta., TGF-beta1 secreted by multipotent mesenchymal stromal cells is responsible for impaired cytotoxic t-cells and natural killer function by down-modulating surface NKG2D expression., study found and validated that the TGFbeta1 rs1800469, We identified causative variation in ten individuals with SGS in the proto-oncogene SKI, a known repressor of TGF-beta activity., TGF-beta1 modulated the expression of key components of the hedgehog pathway., cultured human amniotic epithelial cells undergo epithelial to mesenchymal transition through the autocrine production of TGF-beta., TGF-beta1 induces AQP3 and that AQP3 has a critical role in TGF-beta-induced human peritoneal mesothelial cell migration., Data suggest that serum TGFB1 in diabetes type 1 is significantly higher in children and adolescents as compared with healthy control subjects; TGFB1 level varies with age and duration of diabetes., Expression of ganglioside GM3 and GM3 synthase mRNA are significantly increased in TGF-beta1-induced HLE B-3 cells., TGFB1 SNPs are not associated with the development of nephrogenic systemic fibrosis after gadolinium containing contrast agents., Data indicate that IP-10, TGF-beta1 and IL-18 were associated with T Cell activation at set-point., demonstrated that HCV induced CTGF expression in a TGF-beta1-dependent manner, single-nucleotide polymorphism located on the transforming growth factor-beta-1 gene is associated with radiation pneumonitis in non-small-cell lung cancer., These findings suggest an essential role of Id1 and Id3 in TGFbeta1 effects on proliferation and migration in prostate cancer cells., Up-regulation of cysteine cathepsins B and L and TGF-beta production/signaling were required for the activation of fibroblasts and their promotion of the invasive growth of melanoma cells., conclude that differential inheritance of genetic variants of Tgfbm genes alters biological responses to reduced TGFbeta1 signaling in an experimental asthma mode, These findings indicated that TGF-beta1 RS#1800471G>C polymorphism may be a genetic modifier for developing esophageal squamous cell carcinoma (ESCC) in Zhuangese population., The present meta-analysis results suggest that TGF-beta1 gene promoter -509C allele variant is a possible risk factor for developing colorectal cancer., this meta-analysis supports the TGFB1-509T polymorphism as a susceptibility factor for gastric cancer, results demonstrate that HIF-1alpha transcription and protein synthesis are controlled by TGF-beta1/Smad3 signaling, whereas HIF-1alpha protein stability is controlled by PHD2, which is regulated by TGF-beta1/Smad3 signaling., A meta-analysis indicated that neither TGF-beta -509C>T nor +869T>C polymorphisms were associated with risk of liver cirrhosis., BAG-1 suppresses expression of the key regulatory cytokine transforming growth factor beta (TGF-beta1) in colorectal tumour cells., Cytokine production by SGE cells from SS patients showed a skewed balance compared with normal controls, with increased IL-6 and decreased TGFbeta secretion, Data indicate that TGF-beta1 was co-purified by specific interactions with nickel, and not by specific interactions with fibrillin-1 fragments., Review of roles TGF-beta, particularly TGF-beta1, and BMP-7 play in CKDs (chronic kidney diseases). Targeting the TGF-beta/Smad pathway or restoring BMP-7 signalling may represent novel therapies for CKDs., no association between TGF-beta1 SNPs and radiation-induced lung toxicity in lung cancer European Caucasian patients, Transforming growth factor-beta 1 enhances the invasiveness of breast cancer cells by inducing a Smad2-dependent epithelial-to-mesenchymal transition., The effects of conditional Tif1 gamma knockdown on lactation depend on both TGFbeta and SMAD4., This meta-analysis suggested that TGF-beta1 C-509T polymorphism might contribute to a decreased risk on colorectal cancer susceptibility, especially for Caucasians., Long-term low-dose asymmetric dimethylarginine induces TGF-beta expression in endothelial cells at both the gene and protein levels., Results of this study provide evidence of TGFB1 involvement in endometrial carcinogenesis and indicate potential use as a molecular indicator of disease progression., Cervical cancer cells secrete TGF-beta that inhibits lymphocyte proliferation and induces apoptosis in CD4+, but not in CD8+ lymphocytes., miR-133a mediates TGF-beta-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis., transcription factor GLI1 mediates TGFbeta1 driven EMT in hepatocellular carcinoma via a SNAI1-dependent mechanism, Expression of latent TGF-beta within the allograft kidney tubules may trigger the allograft rejection., no statistically significant associations between either fibrosis or overall toxicity and TGFB rs1800469 genotype were observed in patients received adjuvant breast radiotherapy (Meta-Analysis), findings reveal that the destruction of the TGF-beta-dependent barrier by COUP-TFII is crucial for the progression of PTEN-mutant prostate cancer into a life-threatening disease, results indicate that mitochondrial ROS are essential for normal TGF-beta-mediated gene expression and that targeting mitochondrial ROS might be beneficial in diseases associated with excessive fibrosis, The results suggest a possible link between downregulation of LKB1 and overexpression of SMAD4 in SGTs., The interaction of tumor cells with resident fibroblasts results in hyperactivated TGFB1 signaling., serum IL-10, TNFalpha and TGFbeta differentially associate with dengue disease severity, NSA2, which increases in diabetic nephropathy, may be involved in the actions of TGFbeta1 and contribute to the development of diabetic nephropathy, Our findings indicate that DLX4 induces TOP2A expression but reduces sensitivity of tumor cells to TOP2 poisons by stimulating Ku-dependent repair of DSBs., GDF5 regulates TGF-beta-dependent angiogenesis in breast carcinoma cells., TGF-beta signaling reduces the suppressor activity of CD8(+)T suppressor cells., TGFB1 induced human lung fibroblast proliferation is inhibited by mir-29 family members., 64% of the Wnt signaling components regulated by demineralized bone powder were regulated similarly by the sum of effects by BMP-2 and by TGF-beta1., Human irradiated vocal folds demonstrate molecular changes leading to fibrosis that underlie loss of vocal fold pliability occurring in patients following laryngeal irradiation. Transforming growth factor (TGF)-beta increased in the lamina propria., Transforming growth factor-beta directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas, Taken together, we show that, in contrast to asthma, COPD is characterised by elevated concentrations of both BDNF and TGF-beta1 in serum., Small interfering RNA-targeting atypical protein kinase C reduces TGFB-induced epithelial-to-mesenchymal transition., The results of this study indicate robust stimulation of TGF-beta associated with macrophage infiltration within the human kidney with vascular occlusive disease., TGF-beta1 might be useful as a tumor marker for astrocytomas., This study emphasized the substantial role of the TGF-beta signaling pathway in colorectal cancer, especially in interaction with smoking., Distinct phosphotyrosine-dependent functions of the ShcA adaptor protein are required for transforming growth factor beta (TGFbeta)-induced breast cancer cell migration, invasion, and metastasis, In protocol biopsies from patients on low-dose cyclosporine regimen, expression of TGB-beta1 was not significantly increased along time since transplantation, and did not correlate with cyclosporine exposure., Single Nucleotide Polymorphisms in transforming growth factor beta gene is associated with brain metastasis in non-small-cell lung cancer, The percentage of CD14(high)CD16(+) monocytes after trauma correlated strongly with plasma C-reactive protein (CRP) transforming growth factor-beta (TGF-beta), and macrophage colony-stimulating factor (M-CSF) levels., the plasma concentration of TGF-beta1 in MFS patients might be a useful biomarker of the progression of aortic aneurysms., not needed for production of MMP-9 in nonsyndromic thoracic aortic aneurysm walls, Data suggest that GSK3 (glycogen synthase kinase 3) signaling regulates TGFb1- (transforming growth factor beta 1-) induced myofibroblast differentiation by up-regulating CREB1 (cAMP responsive element binding protein 1) phosphorylation/activation., Results indicate that the crosstalk between IL-6 and TGF-beta1 is associated with malignant features, including epithelial-mesenchymal transition (EMT), and Smad4 works in a dominant manner to promote these features., the suppression of TGF-b1 induced TGF-b3 upregulation, and the suppression of TGF-b2 induced another unexpected downregulation of both TGF-b1 and TGF-b3., Data indicate a dominant role for TRB3 and MAPK-ERK/TGFbeta pathways as Notch regulators in breast cancer, establishing TRB3 as a potential therapeutic target., Significantly elevated levels of TGF-beta have been identified in the anterior chamber of glaucomatous eyes and has also been shown to directly cause increased intraocular pressure., A Kashmiri population representing a homogeneous cohort of common ethnicity revalidates the significance of TGFbeta1 sequence variants, defining their relevance in the pathogenesis of the disease., data support that TGFB1 genetic variation may be an important genetic determinant of mammographic density measure that predicts breast cancer risk, particularly in nulliparous women., Genetic variations in TGFbeta1 is associated with radiation-induced thoracic toxicities in non-small-cell lung cancer., Suggest that the TGF-beta1 gene T869C polymorphism may affect susceptibility to idiopathic pulmonary fibrosis in Koreans., Activators/inhibitors of BMP and TGF-beta signaling play a critical upstream regulatory role in the mDA differentiation process in human pluripotent stem cells., study shows that TGF-beta1 29 C/T polymorphism, but not -509 C/T and 788 C/T polymorphisms, may contribute to the development of chronic periodontitis in a sample of Iranian population, TGF-beta1 induced injured MCL to express more LOXs than injured ACL (up to 1.85-fold in LOX, 2.21-fold in LOXL-1, 1.71-fold in LOXL-2, 2.52-fold in LOXL-3 and 3.32-fold in LOXL-4)., results demonstrate the functional diversity of cancer-associated fibroblasts and show that malignant keratinocytes from genetically unstable oral squamous cell carcinomas reinforce their malignant behavior by inducing fibroblast activation and senescence through ROS and TGF-beta-dependent mechanisms, TGFbeta induces signaling involving PI3kinase-dependent Mnk-1-mediated phosphorylation of eIF4E at Ser-209 to facilitate mesangial cell hypertrophy. A role for dissociation of 4EBP-1-eIF4E complex for Mnk-1-mediated phosphorylation of eIF4E., TGF-beta1 secreted by hepatocellular carcinoma induces the expression of the Foxp3 gene and suppresses antitumor immunity., TGFbeta-stimulated Smad 3 acts as a key node to instill a feedback loop between deptor down-regulation and TORC1/2 activation in driving mesangial cell hypertrophy, this study was to investigate the role of vitamin A in Foxp3 and TGF-beta gene expression in atherosclerotic patients., Integrin inhibition is a promising strategy not only to inhibit angiogenesis, but also to block TGF-beta-controlled features of malignancy., basal or TGFbeta-induced AhR down-modulation could be relevant in the acquisition of a motile EMT phenotype in both normal and transformed epithelial cells, Data indicate that miR-21 potentiates TGF-beta signaling in hematopoietic cells via downregulation of SMAD7., Lower levels of circulating TGF-beta1 are associated with a poor disease prognosis in breast cancer, Data show that the TGF-beta1 codon 10 C allele, and C allele-containing genotypes may be susceptible, and T allele/TT genotype may be protective factors for type 2 diabetes (T2D) and diabetic nephropathy (DN., High TGFB1 expression is associated with rectal cancer recurrence., Data indicate that primary myelofibrosis-derived megakaryocytes expressed increased levels of bioactive Transforming Growth Factor beta1 (TGFbeta1)., Genetic variation in TGFB1 gene and risk of idiopathic recurrent pregnancy loss., OPN regulates the alternative activation of monocytes via TGF-beta1 and monocyte chemoattractant protein (MCP)-1, which may represent an additional mechanism for tumor immune escape., SMAD2 and SMAD3 acetylatation by P300-CBP is mediated by TGFB1 in human lung cancer cells., An meta-analysis suggests that the TGF-beta1 gene -C509T polymorphism would not be a risk factor for IgA nephropathy in Asians but might play a role in Europeans., study demonstrates that the Tgfbr1/Pten 2cKO mouse model of human HNSCC is a useful model for assessing antitumor activity of new cancer therapeutic agents, and that IL-13-PE has therapeutic potential to treat human head and neck cancer, An unbalanced Nodal/transforming growth factor-beta and miR-376c expression may lead to the development of preeclampsia., Transforming growth factor beta-regulated microRNA-29a promotes angiogenesis through targeting the phosphatase and tensin homolog in endothelium., Advanced glycation end-products disrupt the barrier property of the blood brain barrier resulting in up-regulation of TGF-beta., Atrial fibrillation patients without atrial mechanical contraction show higher TGF-beta1 expression than those with atrial mechanical contraction., The TGF-beta1 C-509T CC genotype is associated with better overall survival in unresectable locally advanced non-small-cell lung cancer patients., HCV-induced transcription factors AP-1, Sp1, NF-kappaB and STAT-3 are involved in TGF-beta1 gene expression., These findings provide a line of evidence that the effects of TGF-b and TNF-a were partially mediated by microRNAs, and shed light on the complexity of molecular events elicited by TGF-b and TNF-a., Study highlights the importance of TGFB1 gene for the development and progression of adolescent idiopathic scoliosis., interaction between LPP and alpha-actinin, an actin cross-linking protein, is necessary for TGFbeta-induced migration and invasion of ErbB2-expressing breast cancer cells., TGFBI mutation p.Val631Asp was identified in all subjects.Analysis of this gene offer early diagnosis., The identification and characterization of the Tgif mutant supports the role of TGFbeta signalling in the development of chronic OM., thiol isomerases and thiol-disulfide exchange contribute to TGF-beta1 activation and identify a number of molecules that may participate in the process., This review will focus on the role of TGFB in T cell differentiation and discuss the prospect of TGFB as the therapeutic target of lung transplantation acceptance. [review], Calreticulin, integrin-alpha5, and TGF-beta1 expression was increased in atrial tissue in patients with AF and was related to AF type, suggesting that calreticulin is involved in the pathogenesis of AF in VHD patients., The polymorphisms of tgf-beta1 promoter gene is associated with astham. TGF-beta1 modeulates the severity of asthma, and is associated with atopy of asthmatic subjects., Using 3 different cancer cell lines whose tumorigenic properties are driven by TGF-beta signaling, we show that loss of Arkadia function, either by overexpression of dominant negative Arkadia or by siRNA-induced knockdown, inhibited lung colonization, Inhibition of Smad signaling by expression of Smad7 and dominant negative Smad3 completely abolished TGF-beta-elicited expression of TIMP-3 in human fibroblasts, We conclude that promoter region (-509C>T) and exon 1 (869T>C) polymorphisms are not associated with OPLL in the Korean population., a novel signaling route whereby TGF-beta silences the expression of miR-584, resulting in enhanced PHACTR1 expression, and further leading to actin rearrangement and breast cancer cell migration., TGF-beta1 is involved in reprogramming of Schwann cell phenotype, leading to transdifferentiation of neural cells in leprosy., TGF-beta may play a role in maintaining the homeostasis of intervertebral disc tissue., Mesenchymal stem cells ameliorate experimental peritoneal fibrosis by suppressing inflammation and TGF-beta1 signaling in a paracrine manner., ). There were no significant differences in CVF (p=0.12), in CTGF (p=0.60), and in TGF-beta expression (p=0.66) in the atrial myocardium between the two study groups., TGF-beta and TNF-alpha act in concert to activate apoptosis in gastric cancer cell through crosstalk between Smad and JNK signaling pathways., The results of this study suggest that abnormal bone turnover marker levels, typical radiological findings and mutations in the TGFbeta1 gene are three important factors in the diagnosis of sporadic CamuratiEngelmann disease cases., miR-30e/UCP2 axis has an important role in mediating TGF-beta1-induced epithelial-mesenchymal transition and kidney fibrosis., Serum TGF-beta 1 and urinary MCP-1 can be used as the markers for detection of progression of diabetic nephropathy., Our results indicate the association of IL-10 -3575 and TGF-b Leu10Pro gene variations with clinical characteristics., important roles of endothelial cells within the prostate cancer microenvironment to promote the prostate cancer metastasis and provide new potential targets of IL-6-->AR-->TGFbeta-->MMP-9 signals to battle the prostate cancer metastasis, The level of TGF beta1 was increasing during the admission and had the maximum level at the 7th day after diffuse axonal injury, Variation in two TGFbeta1 tagged-SNPs (rs4803455, rs4803457) was associated with preeclampsia in black women., Gremlin gene silencing inhibited TGF-beta1-induced epithelial mesenchymal transition in kidney., These findings uncovered a novel role of nestin in regulating TGF-beta1-induced epithelial-mesenchymal transition., Activation of canonical TGF-beta signalling is a major contributor to fibrosis and matrix remodelling in myxomatous mitral valve disease, and is amplified by increases in oxidative stress., tumor-associated soluble and membrane-bound TGF-beta are involved in the regulation of intratumoral T cell differentiation and function in B-cell of non-Hodgkin lymphoma, CCN2 in the intervertebral disc is regulated by TGF-beta and hypoxia via HIF-1alpha, the critical determinants that characterize the disc microenvironment in health and disease. (Review), Notch4-dependent antagonism of canonical TGF-beta1 signaling defines unique temporal fluctuations of SMAD3 activity in proximal tubular epithelial cells exposed to shear stress., results can suggest the lack of association between TNF-alpha 308 G/A and TGF-beta1 800 G/A gene polymorphisms with COPD development and airway resistance in Turkish population, Caveolin-1 conveys a homeostatic antifibrotic function by regulating TGF-beta1 and its downstream signaling; regulating critical cellular processes involved in tissue repair; antagonizing cell proliferation.(Review), TGFbeta1 exposure alone significantly increased expression of alphaSMA, CTGF, COL1A1 and COL3A1, HAS2-dependent production of HA facilitates TGF-beta1-dependent fibroblast differentiation through promoting CD44 interaction with EGFR held within membrane-bound lipid rafts., TGFbeta1 gene polymorphisms interact with being overweight to influence the risk of large joint osteoarthritis, inactivation of TGF-beta signaling and loss of PTEN cooperate to drive intestinal cancer formation and progression by suppressing cell cycle inhibitors, TGF-beta1 mediates selective atrial fibrosis in atrial fibrillation that occurs via TGF-beta Receptor 1/2 and the classical Smad pathway., Autoimmunity may have been triggered as a result of a decreased immunosuppressive effect induced by depressed TGF-beta1 levels in patients with systemic lupus erythematosus and Hashimoto's thyroiditis., Data indicate that all investigated cell lines secreted TGF-beta1 within the range previously reported for primary clear cell renal cell carcinoma (ccRCC) cell cultures., Reduced expression of TGF-beta1 stimulates HBV replication and immune response., Data indicate that the level of TGF-beta did not differ between Common variable immunodeficiency (CVID) patients and controls while the amount of IL-10 was remarkably decreased in CVID patients., Tensile strain increases expression of CCN2 and COL2A1 by activating TGF-beta-Smad2/3 pathway in chondrocytic cells., No significant differences were observed between Graves disease and control subjects for IL-10, TGF-beta, and INF-gamma gene polymorphisms., AEG-1 plays an important role in TGF-beta1-induced epithelial-mesenchymal transition through activation of p38 MAPK in proximal tubular epithelial cells., This meta-analysis suggests a possible association between TGF-beta1 +869C/T promoter polymorphism and rheumatoid arthritis, especially in Asian population., Data show expression of TGF-beta1, TGF-beta2, BMP-4, and BMP-7 was increased in tumor-associated macrophages (TAMs) cocultured with pancreatic cancer cells, and vasohibin-1, VEGF-A, and vVEGF-C expression in pancreatic cancer cells was upregulated by TAMs., Meta-analysis indicates that TGF-beta1 -509C/T (or +869T/C) polymorphisms are not associated with risk of hepatocellular carcinoma. [Meta-analysis], The proliferation of human adipose-derived stem cells correlated with the concentration of PDGF-AB, BB and TGF-beta1., TGF-beta regulated the expression of miR-21 and fibrosis-related genes, and decreased Smad7 expression in scleroderma fibrosis., Higher serum levels in patients with anaphylaxis, Data indicate that TGF-beta1 and miR-450b-5p correlated in rhabdomyosarcoma (RMS) tissue., Endothelial cells may play a role in the induction and maintenance of EMT in tumor cells by constitutively releasing TGFbeta1 and TGFbeta2, IL-13 potentiates airway remodelling through a mechanism involving collagen type I expression, TGF-beta1 and MMP-2, Data suggest that targeting transforming growth factor-beta (TGF-beta) with either monoclonal antibodies or small molecule inhibitors is a potentially promising strategy for treating patients with myelofibrosis(MF) and that merits further investigation., Increased TGF-beta1 bioavailability may contribute to the pathogenesis of polycystic ovarian syndrome and its increased risk for ovarian hyperstimulation., These findings for the first time define H2O2 as a signaling molecule that modulate Smad3 linker phosphorylation., study shows that there is strong association between TGF-beta1 29C/T gene polymorphisms and quantitative parameters of interdental papilla in patients with CP., These data do not confirm a crucial role of TGF beta1 and TGF beta2 release in the development of posthemorrhagic hydrocephalus, Hypoxia stimulates the EMT of gastric cancer cells through autocrine TGFbeta signaling., This study identified a risk variant c.-509C > T and a risk haplotype G-T-T-G in the TGFB1 gene that contribute toward the susceptibility to otosclerosis., TGF-beta signaling pathway plays a dichotomous role in hepatocellular carcinogenesis., High Transforming growth factor beta 1 is associated with bronchioloalveolar invasion in non-small cell lung cancer., TGF-beta1 blockade and IL-12p70 production augments antitumor immunity in tumor and dendritic cell fusions., we found that TGF-beta induced expression of CTGF was not mediated by TGF-b activated Smad signaling but mediated by TGF-beta activated Erk, JNK and p38 MAPK signaling, Data from 14-year-old girl and her father suggest that a missense mutation (R218C) in exon 4 of TGFB1 (transforming growth factor beta 1) can result in leg pain and other symptoms of Camurati-Engelman disease. [CASE REPORT], Expression of transforming growth factor-beta (4.3 +/- 1.4 vs 2.6 +/- 2.3, p = 0.01) and calponin (3.7 +/- 0.7 vs 0.6 +/- 1.1, p = 0.05) was lower from infants with vs without a PDA., TGF-beta enhances IL-21-induced differentiation of human IL-21-producing CD4+ T cells via Smad3., summarize recent knowledge of BMP-7 function and discuss attempts to use this cytokine as a drug to reverse TGF-beta-induced fibrogenesis, Urinary TGF-beta1 can be used as a biomarker for the early recognition of ongoing renal damage in patients with posterior urethral valves., The balance of positive and negative effects of TGF-beta1 signaling regulates the development of hematopoietic and endothelial progenitors in human pluripotent stem cells., IL-10 and TGF-beta, as well as cell surface molecules PD-L1 and ICOS seem to be significantly involved in the redirection of dendritic cells towards tolerance induction in cancer. (Review), This is the first report elucidating a feedback regulation between miR-127 and the TGFbeta/c-Jun cascade in hepatocellular carcinoma migration via MMP13., Studies indicate that TGF-beta1 regulates inducible nitric oxide (NO) synthase (iNOS) both positively and negatively., Expression of TGFB1 in nasal epithelial cells was higher in nasal polyps compared to control mucosa., the cellular location of the phosphorylation event and the importance of the linker region in regulation and expression of genes induced by TGF-b are covered., our study here revealed that thyroid hormone T3 could inhibit TGFb1 induced renal tubular epithelial to mesenchymal transition by increasing miR34a expression., a nuclear envelope-localized mechanism of inactivating TGF-beta signaling in which MAN1 competes with transcription factors for binding to Smad2 and Smad3 and facilitates their dephosphorylation by PPM1A., This study showed that, by targeting SMURF2, NS3-4A appears to block the negative regulation of TGF-beta signaling, increasing the responsiveness of cells to TGF-beta., results show that Brachyury expression is enhanced during TGF-beta1-induced epithelial-mesenchymal transition in human cancer cell lines and that a positive feedback loop is established between Brachyury and TGF-beta1 in mesenchymal-like tumor cells, Thus, our findings highlight the cyclin D1/p21 signaling axis as a critical regulator of TGFb-mediated tumor growth initiation and local tumor cell invasion, both in vitro and in vivo., Cc genotype of TGF-beta1 gene was found as a risk factor (odds ratio, Our results integrated TGF-beta1 signals to SKP2 via Akt1 and c-Myc during epithelial-mesenchymal transition in melanoma., Patients who receive living-related liver transplantation due to inherited metabolic diseases are prone to higher oxidative stress, complement 5a activity, and serum transforming growth factor-ss1., identified the possible effect of interleukin 6 (IL-6), transforming growth factor beta 1 (TGFB1), and Fas SNPs on renal graft function, The density of macrophages in colorectal cancer is inversely correlated to TGF-beta1 expression and patients' survival., Data suggest that serum TGFb1 level is not reliable biomarker for valvular fibrosis and calcification as adverse effects of dopamine agonist treatment in patients with prolactinomas, but serum TGFb1 may be useful biomarker for tumor invasiveness., we show that increased expression of SMalphaA protein during TGFb1-induced myofibroblast differentiation was associated with the formation of YB-1 oligomers exhibiting SMaA mRNA-binding activity., a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7., The TGF-beta1 (codons 10 and 25) CC GG genotype, which was present in a relatively small proportion of the idiopathic pulmonary fibrosis (IPF) patients compared to the controls, was associated with decreased disease severity., Similarly inhibits TGF-beta1-stimulated CCN2/CTGF expression., Missense p.Arg156Cys mutation in the TGFB1 gene is associated with camurati-Engelmann disease with obesity., Serum TGFB1 levels in Alzheimer disease patients were significantly lower than in controls., TGF-beta1 regulates the cell cycle via survivin., TGFbeta activation plays an important role in mechanotransduction., These results suggest an important role for TGF-beta1 in osteosarcoma cell growth, with the induction of IGFBP-3 by TGF-beta1 serving in a negative-feedback loop to control cell growth by preventing activation of the IGF1R., Pulmonary endothelial cell injury in a scleroderma mouse strain triggers pulmonary hypertension and supports the underlying role of functional interplay between TGFbeta and VEGF., role of p.R218C in TGFbeta1 on the mechanism of the disease, and the complications of it in bones and endocrine glands, remains unclear, current epidemiological studies of TGF-beta1 T869C polymorphism are too inconsistent to draw a conclusion on the association with IS susceptibility., Taken together, our meta-analysis did not provided an evidence of confirming association between TGF-beta1 (codon 10, codon 25, -509C/T) gene polymorphism and systemic sclerosis., APRIL depletion induces cell cycle arrest and apoptosis partly through blocking noncanonical TGF-beta1/ERK., Our results suggest that elevated expression and tyrosine phosphorylation of p130Cas contributes to the resistance to TGF-beta-induced growth inhibition., Polymorphisms in the TGFB1 gene is associated with uterine cervical cancer., These findings indicate crosstalk between p38 and smad3 through TGF-beta1 in choriocarcinoma cells., Serum TGFB1 was elevated in patients with classic prolapse as compared with the control group and the non-classic mitral valve prolapse group., Atrial fibroblasts show greater fibrotic and oxidative responses to TGF-beta1 than ventricular fibroblasts and suggest role for Nox4., This study observed only a modest increase, if any, in TGFbeta1 levels of female Pro-allele carriers of the L10P polymorphism., TGF-beta signaling promotes exit from the cell cycle and cellular migration through cullin cross-regulation, Our results suggest that Egr-3 is a transcription factor associated with TGF-beta1 expression and in vivo regulatory activity, Studies suggest that tumor necrosis factor beta (TNF-beta) 252 A/G polymorphism is associated with the risk of gastric cancer, especially in Asians., Data indicate that high levels of TGF-beta followed by adaptation of FoxP3(+) naive and memory (CD4(+)CD45RA(+)/RO(+)) T cells were observed as the principal underlying factors leading to higher generation of T reg cells during disease progression., The levels of p-EGFR in HCC and CHC patients show a highly significant difference between patients., TGFbeta1 has a fundamental role in intestinal homeostasis and oral tolerance to low antigen doses., The activated TLR4/NANOG oncogenic pathway is linked to suppression of cytostatic TGF-beta signaling., A synergic action was noted between TGF-beta1, IL-4 and IL-17A in terms of induction of bronchial epithelial-mesenchymal transition, Our findings indicate that Cf-GP inhibits AGS cell proliferation and migration by downregulating integrin expression via the TGF-b1-activated FAK/PI3K/AKT pathways., Extracellular vesicles are potent stimulators of MMP-9, IL-6, TGF-beta1 and induce the secretion of extracellular EMMPRIN, TGF-beta1 reduces BMP4 signaling in pulmonary artery smooth muscle cells, a response that is exacerbated on the background of reduced BMP responsiveness due to BMPR-II mutations., PARP-1 regulates expression of transforming growth factor-beta (TGF-beta) receptors and TGF-beta signaling in T cells, The presence of the G/G genotype of TGFB1 SNP in Mexican patients was significantly associated with severity of liver fibrosis., reviews the two faces of TGF-beta signaling in the regulation of tumorigenesis., These data suggest a dual role for TGFbeta signaling during lymphatic network morphogenesis in the skin., The TGFBR2-875G>A contribution to an early relapse in androgen-deprivation therapy patients supports the involvement of TGFbeta1 pathway in castration-resistant prostate cancer., Lungs of patients with schistosomiasis-associated pulmonary arterial hypertension have evidence of TGF-beta signaling in their remodeled pulmonary arteries., IL-17 and TGF-beta1 may be involved in the occurrence and development of asthma, and they play important roles in asthma attack and aggravation., Urine marker TGFB1 may predict urinary tract impairment in children with myelodysplasia. and may differentiate at risk patients with either renal scarring or high detrusor leak point pressure., TGFbeta1 Leu10Pro polymorphism contributes to the development of prostate cancer., The present meta-analysis results suggest that TGF-b1 -509C/T variants may not contribute to the risk of breast cancer overall, Lymphangiogenesis associates with fibrosis through the TGFbeta-vascular endothelial growth factor (VEGF)-C pathway., features may be relevant to discriminate stage dependent TGF-beta functions for the design of efficient TGF-beta directed therapy in liver cancer, Single nucleotide polymorphism in TGFB1 gene is associated with ER-negative breast cancers only in American women of African ancestry., The total CTGF production induced by TGF-beta in activated HSCs is therefore, to a large extent, dependent on the balance and integration of the canonical Smad3 and Stat3 signaling pathways, Complicated malaria was associated with enhanced expression of IFN-gamma and TGF-beta but lower IL-2 and IL-12alpha in comparison to uncomplicated malaria., These finding suggest that there is an increased expression of TGF-beta and CTGF, a TGF-beta regulated protein, and that this TGF-beta activation may be responsible for fibrosis in carpal tunnel syndrome patients., The synergistic effects of ET-1 on serum and TGF-beta1 involve ERK1/2 MAPK and may thus present a novel mode of action in the pathogenesis of pulmonary arterial hypertension., Our meta-analysis suggested that the TGF-beta1 +869C/T and -509C/T polymorphisms may be risk factors for developing hepatocellular carcinoma.[meta-analysis], TGF-beta1 promoter is methylated in gastric cancer patients., IgA1 complexes from IgA nephropathy patients could up-regulate the secretion of CXCL1 and TGF-beta1 in mesangial cells., TBX3 plays a pivotal role in mediating the antiproliferative and promigratory role of TGF-beta1 in breast epithelial and skin keratinocytes., Obstructed kidneys from CD44v3 transgenic mice showed less tubular damage and myofibroblasts accumulation, which was associated with decreased TGF-beta1 signaling compared with kidneys from wild-type and CD44s transgenic mice., TGF-beta/Smad, integrin/integrin-linked kinase (ILK) and wnt/beta-catenin signaling pathways are involved in epithelial to mesenchymal transition in human renal fibrogenesis., Orai1 is expressed in the human endometrium and is up-regulated by SGK1 and TGFbeta1., TGF-beta1, acting, in part, via mTOR, increases mitochondrial membrane potential and oxygen consumption, resulting in increased ROS generation and that this may contribute to podocyte injury., Transforming growth factor-beta3 (TGF-beta3) knock-in ameliorates inflammation due to TGF-beta1 deficiency while promoting glucose tolerance., TGF-beta1 G915C, G800A, and C509T gene polymorphism are not associated with the DN risk., Data suggest that the IL-10-1082 A>G (rs1800896), TGF-beta1-509 T>C (rs1800469), and TGF-beta1 T29C (rs1800470) SNPs play an important role in the risk of developing Silent myocardial ischemia (SMI)., This is the first report showing the association between TGFB1 +869T>C polymorphism and schizophrenia., Report the activation of TGFbeta/Smad signaling pathway in the airways of children with asthma despite regular inhaled corticosteroid treatment., OTUB1 enhances TGF-beta signaling by inhibiting the ubiquitylation and degradation of active SMAD2 and SMAD3., TGFB1 gene polymorphisms may be associated with susceptibility to the development of Crohn's disease (CD), and IL10 gene polymorphisms appear to influence the CD phenotype in this admixed population., In accordance to the observed similarity between TGF-beta variants and miR-21 gene expression alterations in bladder tumors, treating 5637 bladder cancer cell line with TGF-beta recombinant protein caused a significant upregulation of miR-21., High TGF beta is associated with myelofibrosis., present data suggest that TGF-beta1 may be important in the pathogenesis and progression of intracranial deep white matter lesions, The present study developed an efficient strategy for differentiating human hair follicle stem cells into contractile smooth muscle cells by stimulation with TGF-beta1 and PDGF-BB., Renal fibrosis resulting from excessive accumulation of extracellular matrix mainly driven by TGF-beta1 is dependent on the regulation of transforming growth factor receptor 1 expression by let-7b., Gene transcripts for known upstream and downstream TGF-beta mediators are differentially expressed in liver specimens from children with biliary atresia and a fibrogenic gene signature., TRPV1 potentiates TGFbeta-induction of corneal myofibroblast development through an oxidative stress-mediated p38-SMAD2 signaling loop., TGF-beta induces miR10a/10b expression and TGF-beta-induced miR10a/10b expression promotes cell migration through the suppression of PTEN., Snail mediates TGF-beta1-induced down-regulation of VE-cadherin, which subsequently contributed to TGF-beta1-decreased trophoblast cell invasion., Brucella abortus induces collagen deposition and MMP-9 down-modulation in hepatic stellate cells via TGF-beta1 production., in the skin affected by bleomycin-induced fibrosis, increased TGF-beta1 expression suppresses adipogenesis and promotes adipocyte fibrosis, IGFBP-5 is important in maintaining epithelial-mesenchymal boundaries and thus may limit metastasis and fibrosis by inducing an orderly repair mechanism, very distinct from the fibrotic disruption induced by TGFbeta1., Nox4-derived reactive oxygen species, at least in part, transmit TGF-beta-triggered epithelial-mesenchymal transition signals through PTP1B in pancreatic cancer., TGF-beta1 resulted in epithelial-mesenchymal transition in bronchial epithelial cells, characterized by decrease in E-cadherin expression and the increase in vimentin and alpha-smooth muscle actin expression, and the associated increase in Snail expression., under hypoxic conditions, POSTN regulates PHD2 expression and HIF-1alpha levels by modulating TGF-beta1 signaling, leading to decreased apoptosis., TGF-b1 is capable of eliciting anti-inflammatory effects by inhibiting NF-kappaB specifically in the intestinal epithelium as well as by decreasing systemic IL-6 and IFN levels, no statistical evidence for an association between SNPs in TGFB1 and risk of late radiation-induced injury of normal tissue., We conclude that WASp function restricts TGF-b1 secretion in a Cdc42- and Src family kinase-dependent manner and independently of actin assembly, Studied expression of TGF-beta1, Smad3 and IL-6 in 50 cases with atrial fibrillation (AF) and 30 normal cases. The TGF-beta1, Smad3 and IL-6 mRNA and protein expression levels in patients with AF were significantly higher than that in the control., FOXO1 coordinates the response of keratinocytes to wounding through up-regulation of TGF-beta1 and other factors needed for keratinocyte migration and protection against oxidative stress, which together promote migration and decrease apoptosis., c.29C>T and c.74G>C polymorphisms in the TGF-beta1 gene significantly affect breast cancer risk, which correlates with elevated TGF-beta1 level in the patients., Both TGF-beta1 and TNF-alpha modulate clinical severity and airflow limitation in an additive manner in COPD., transforming growth factor beta produced by fibroblasts increased spheroid formation and expression levels of cancer stem cell markers in cancer stem cells, a process inhibited by inhibitors of TGF-beta signaling., The REGgamma-proteasome pathway is regulated diffentially by p53/TGF-beta signaling and mutant p53 in cancer cells., genetic polymorphism is associated with progression of hepatitis B to hepartocellular carcinoma in India, Data indicate that signaling by HIV-1 gp120 through integrin alpha4beta7 resulted in increased expression of the immunosuppressive cytokine TGF-beta1 and FcRL4., moderate risk of bias show a statistically significant association with the ACE gene, AGT gene, OTSC2, RELN gene, TGFB1 gene, 11q13.1, OTSC2, OTSC5, OTSC8, and OTSC10. [Review], The data indicate that osteosarcoma cells secrete TGF-beta to maintain the stemness of MSCs and promote the production of pro-tumor cytokines by these cells., Higher TGF-beta with lower CD124 and TSLP, but no difference in PAR-2 expression in bronchial biopsy of bronchial asthma patients in comparison with COPD patients., The usefulness of serum Transforming growth factor-beta1 (TGF-beta1), Glypican-3 (GPC3), and Golgi protein-73 (GP73) mRNAs as early biomarkers in HCC Egyptian patients, was investigated., SLP-2 was upregulated by TGF-beta1, indicating a possible role of SLP-2 in Papillary thyroid cancer tumorigenesis., TGFbeta induced PLOD2/LH2 expression in human synovial osteoarthritic fibroblasts through ALK5 signaling., did not find any association between 5557G>A polymorphism in the ATM gene or single TGFB1 polymorphisms and late toxicity, Co-stimulation with EGF and TGFB1 results in rapid and robust ERK1/2 activation and induces persistent high expression of Snail protein., miR-1207-5p, a PVT1-derived microRNA, is abundantly expressed in kidney cells, and is upregulated by glucose and TGF-beta1., The activation of TGF-beta and Notch signaling pathways may be involved in the bacteria-mediated proliferation of aortic smooth muscle cells ., serum TGF- beta 1 concentrations are one of the factors that may have an impact on the progression of vascular complications in children and adolescents with T1DM, The ratio of TGF-beta1/IL-17 is associated with disease progression in patients with HBV-liver cirrhosis., IKKgamma facilitates RhoA activation via a guanine nucletotide exchange factor, which in turn activates ROCK to phosphorylate IKKbeta, leading to NF-kappaB activation that induced the chemokine expression and cell migration upon TGF-beta1., The effect of TGF-beta1 and BMP-4 on bone marrow-derived stem cell morphology on a novel bioabsorbable nanocomposite material., This meta-analysis suggested that the T allele of TGF-beta1 509C/T polymorphism is probably the susceptibility factor for gastric cancer, TGF-beta interfered with NFAT3 translocation, and subsequently with miR-140 expression, Treatment with GM-CSF increased the expression of vimentin and ZEB1, similar to TGF-b1 treatment, and decreased the expression of E-cadherin., Smad7 enhanced ubiquitylation of Myc through direct interaction with Myc and recruitment of Skp2. Ablation of Smad7 resulted in less sensitivity to the growth inhibitory effect of TGF-beta by inducing stable Myc expression., genetic polymorphisms may be risk factor for asthma susceptibility, TGF-B1 509T/C, P-selectin-2441A/G and MCP-1 2518A/G had combined effects on the formation of crescents in IgAN patients., IL-22 contributes to TGF-beta1-mediated epithelial-mesenchymal transition in asthmatic bronchial epithelial cells., Both heterozygotes of C509T polymorphism and T allele of T869C polymorphism in TGFbeta1 were associated with the risk of IgAN in Caucasians, but not in Asians, Impact of TGF-b on breast cancer, a high level of miR-106b induced by TGF-beta determines the tumor-promoting effects of TGF-beta in breast cancer, Suggest role for TGFB1 regulation of epithelial-mesenchymal transition proteins in synovial sarcomas., In chronic subdural hematomas, the expression of TGF-beta was slightly increased in the dura and markedly up-regulated in the outer membrane., FGFR1, WNT, and TGF-beta have roles in signaling of reactive stroma in aggressive prostate adenocarcinomas, Immunochemistry and clinicopathological results showed that the expression of NT5E and FcGBP in gallbladder adenocarcinoma is an independent marker for evaluation of the disease progression, clinical biological behaviors and prognosis., The expression of TGFB1 and TGFB2 increase significantly in benign prostatic hyperplasia treated with 5-alpha reductase inhibitor., Our results suggest that IL-2 (-330T/G), IL-4 (-589 C/T) and TGF-beta1 (+869T/C) gene polymorphisms may be associated with TB susceptibility., TGF-beta1 TT genotype may determine the development of osteoporosis., The results of this study identify a unique microglial signature that is dependent on TGF-beta signaling and provide insights into microglial biology and the possibility of targeting microglia for the treatment of CNS disease., c-Met and CD44v6 receptors have roles in autocrine TGF-beta1 signaling in interstitial lung disease, ZNF451 acts as a transcriptional corepressor for Smad3/4 and negatively regulates TGF-beta signaling., expression of TGF-beta1 and FGFR4 could make synergy on the occurrence and progression of HCC, and may be used as prognosis indicators for HCC patients, The differential and synergistic effect of retinoic acid and TGF-beta on switching of different B cell subpopulations to IgA, is reported., These data indicate that reduced bioavailability of TGF-beta1 in the serum of Huntington disease subjects., Identify a novel mechanism of interaction between TGF-beta1 and miR-21 in the regulation of FasL protein, which is involved in keloid formation., Keratoconic corneas are distinguished with high expression of TGF-beta1 and DUSP1., study shows that Id2, Id3 and Id4 are each able to overcome TGF-beta dependence, and establish a role for Ids as key mediators of TGF-beta melanomagenesis, Glucocorticoids recruit Tgfbr3 and Smad1 to shift transforming growth factor-beta signaling from the Tgfbr1/Smad2/3 axis to the Acvrl1/Smad1 axis in lung fibroblasts., An impairment of the transforming growth factor-beta1 (TGF-beta1) signaling pathway has been demonstrated to be specific to the AD brain., results do not support the role of the TGFB1 rs1800469 functional gene variant in the development of AF in the Chinese Han population., role of Id2-TGFbeta crosstalk in reversible adaptive plasticity in neuroblastoma, PDGF positively modulates the TGF-beta-induced osteogenic differentiation of hMSCs through synergistic crosstalk between MEK- and PI3K/Akt-mediated signaling., Smad3 plays an important role in the TGF-beta/Smad3 signaling pathway., FOXM1 promotes breast cancer metastasis by increasing nuclear retention of SMAD3; there is crosstalk between FOXM1 and TGF-beta/SMAD3 pathways, ALCAM expression and shedding is elevated in response to TGF-beta signaling., miR-181a promotes TGF-beta-mediated epithelial-to-mesenchymal transition via repression of Smad7., Compared to controls, plasma levels of TGF-beta1 and TGF-beta2 were significantly lower in patients with recurrent VTE (p < 0.05), whereas no difference was found for TGF-beta3., A quantitative parameter for antigen-induced cytokine-mediated regulation (R(AC) of HIV-specific effector T cell activation by functional antibody-blockade of IL-10 and transforming growth factor-beta, is reported., Studied the expression of E-cadherin, N-cadherin, TGF-beta1 and Twist protein and investigate its significance in the occurrence and development of prostate cancer., TGFB1-mediated induction of the short MKL1 isoform initiates progression to later stages of differentiation towards a stationary myofibroblast., no association between the studied SNPs of TGFbeta1 and breast cancer among Iranian women., High expression of IGFBP7 in fibroblasts induced by colorectal cancer cells is co-regulated by TGF-beta and Wnt signaling in a Smad2/3-Dvl2/3-dependent manner., TT genotype of TGF-beta1 T869C in the overall population was associated with diabetic nephropathy risk, Levels of TGF-beta1 and corresponding mRNA are elevated during the active stage of IBD but not during the remission. Longitudinal assessment of this cytokine in a single patient may help to monitor the clinical course of inflammatory bowel diseases ., Investigated the effect of Id1 on TGF-beta-induced collagen expression in dermal fibroblasts. When Id1-b isoform was overexpressed, TGF-beta-induced collagen expression was markedly inhibited., The increased TGF-beta signaling in Marfan Syndrome and Loeys-Dietz Syndrome implies a relationship between the normal development of connective tissue and the cardiovascular system. (Review), TGFb1 rs1800469 C>T polymorphism was significantly associated with decreased risk of conotruncal heart defects. TGFbetaR2 and VEGF polymorphisms may not play a role in the susceptibility of conotruncal heart defects., TGF-beta upregulates miR-182 expression to promote gallbladder cancer metastasis by targeting CADM1., Data show down-regulation of cyclic adenosine monophosphate (cAMP) was the secondary signalling after H4 receptor activation, which in turn resulting in inactivation of transforming growth factor-beta1(TGF-beta1) pathway., Urothelial bladder carcinoma displayed elevated expression for cyclin D1, VEGFA and TGFbeta1., Nox4 and reactive oxygen species have pivotal roles in mediating TGF-beta-induced endothelial apoptosis., Helicobacter pylori vacA increase markedly gastric mucosal TGF-beta1 mRNA expression in gastritis patients., These findings suggest that IL-10 and TGF-beta1 genotypes are related to the age of acute otitis media onset, multiple acute otitis media episodes and insertion of tympanostomy tubes., High TGFBI levels were associated with longer overall survival (OS, P<0.001) and progression-free survival (PFS, P<0.001) in SCC patients who received adjuvant platinium-based chemotherapy., Show a dual direct and indirect involvement of TGFB1, cytokines and eosinophil-derived mediators in the fibrosis and dysmotility that characterize esinophilic esophagitis., This meta-analysis and systematic review suggested that donor TGFB1 +869T/C polymorphism was significantly associated with AR of solid organ transplant recipients, Human induced pluripotent stem cells absolutely required TGFB1 to maintain pluripotency., Nox4 NADPH oxidase may be an important downstream effector in mediating TGF-beta-induced fibrosis, while NADPH oxidase-dependent redox signaling may in turn regulate TGF-beta/Smad signaling in a feed-forward manner. Review., Subjects with type 2 diabetes and LDL phenotype B have higher levels of TGF-Beta1., Data show that TGF-beta1 precursor was an independent positive prognostic factor for distant disease-free survival in patients received adjuvant chemotherapy., These results suggest that miR-218 regulates the ability of TGFbeta to induce myofibroblast differentiation in fibroblasts via cezanne/FAK., Studies indicate that transforming growth factor beta (TGF-beta) superfamily members regulate early embryonic development., Par-4 is a target of TGF-beta signaling and acts as an important factor during TGF-beta-induced epithelial-to-mesenchymal transition., Infusion of IL-10/TGF-beta1 cotransfected dendritic cells induces alloantigen-specific T cell hyporesponsiveness, inhibits antigen-specific immunological responses to liver allografts, prolongs liver allograft survival, and enhances the immune tolerance., Studies suggest that the unmasking of receptor binding epitopes of transforming growth factor beta (TGFbeta) is only one (and in some cases a non-essential) function of precursor processing., Although TGF-beta initially inhibits epithelial growth, it appears to promote the progression of advanced tumors., Transforming growth factor-beta1 downregulates vascular endothelial growth factor-D expression in human lung fibroblasts via the Jun NH2-terminal kinase signaling pathway, Dll4/Notch signaling in tumor cells magnified TGF-beta-induced pSMAD2/3 signaling and was required to sustain TGF-beta-induced tumor cell growth, Respiratory exposure to multi-walled carbon nanotubes induced length dependent pulmonary fibrosis and epithelial-derived fibroblasts via TGF-beta1/Smad2 pathway., Serum TGF-beta1 and SMAD3 levels are closely associated with coronary artery disease, and may become useful biomarkers for diagnosis and risk stratification., Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-beta (TGF-beta) signaling promoting SMAD3 activation and fibrosis via Gremlin protein., TGF-b1 suppressed Cdo1 gene transcription through the MEK/ERK pathway., Authors show that human herpesvirus 4 EBNA2 represses BIK in B-cell lymphoma-derived cell lines and that this host-virus interaction can inhibit the proapoptotic effect of transforming growth factor beta1., T869C, C509T, G915C polymorphisms not associated with IgA nephropathy risk [review], compartment of myeloid stroma cells, such as tumor-associated macrophages, neutrophils, and dendritic and mast cells, which are potently regulated by TGF-beta and produce large amounts of MMPs., Genetic polymorphism in TGFB1 is not associated with acute rejection in renal transplantation., HOXB9 overexpression increased the tumorigenicity of glioma cells in vivo. Moreover, the activation of transforming growth factor-beta1 contributed to HOXB9-induced oncogenic activities., Patients with lipodystrophy had higher expression of TNF-alpha and caspase-3 and lower TGF-beta, compared to the control group., We identified different markers that correlated with increased risk of organ-specific graft vs host disease (for example, FCGR2A SNP for oral GVHD, and FAS and TGFB1 SNP for lung GVHD)., TGF-beta-inducible microRNA-183 silences tumor-associated natural killer cells., expression of the antioxidase glutathione peroxidase 1 in pelvic support structure of pelvic organ prolapse women was decreased, which resulted in the antioxidation reduced and may induce down-regulation of transforming growth factor-beta1-CTGF pathway, Results indicate that inflammatory signaling through LTB4 may be more closely linked to calcification and aortic stenosis than signaling through TGF-beta1 and microparticles., TGF-beta signaling modifies the severity of recessive dystrophic epidermolysis bullosa disease in monozygotic twins., High transforming growth factor-beta1 expression is associated with metastasis in breast cancer., Reveal an opposite role of Hsp70 and Hsp90 in regulating TGF-beta signaling by implicating CHIP-mediated Smad3 ubiquitination and degradation. This study provides a new insight into understanding the regulation of the TGF-beta signaling by chaperones., These studies highlight the role of free radicals in p53 activation and subsequent pro-fibrotic reprogramming by TGF-beta1 via the SMAD3-p53 transcriptional axis., This study demonstrated that there is a significant contribution of -509C/T and 869T/C (codon 10) polymorphisms of tgf-beta1 in pediatric migraineurs., the effects of IL1beta, TGFbeta1, and IL1beta in combination with TGFbeta1 on myofibroblast formation, Antagonism of TGF-beta signaling by TGF-beta neutralizing antibody, short hairpin RNA-mediated Smad3 or Smad2 knockdown, Smad3 haploinsufficiency, or endothelial cell-specific Smad2 deletion resulted in decreased endothelial-to-mesenchymal transition., High serum levels of transforming growth factor-beta1 is associated with low response to therapy in esophageal squamous cell carcinoma, This review will discuss the role of PPP1 in the regulation of several TGF-beta signalling members and how the subversion of this pathway is related to prostate cancer development., Smad3 and phospho-Smad3 protein levels gradually decreased while TGF-beta1 mRNA level gradually decreased and the Smad7 mRNA level gradually increased from normal anterior pituitaries, noninvasive NFPAs, to invasive NFPAs., breast cancer cell was deficient in Dab2 expression and related receptor endocytosis-mediated TGF-beta depletion, which may contribute to the accumulation of TGF-beta in tumor microenvironment and the induction of immune tolerance., The T869C polymorphism of TGF-beta1 may be associated with radiation pneumonia risk only in Caucasians; there may be no association between C509T and G915C polymorphism and radiation pneumonia risk. (Meta-analysis), Our findings strengthen the association of TGFB1 (rs1800472) with otosclerosis., Low expression of TGF-beta1 protein is associated with a poor prognosis for patients with stage III rectal cancers, Nuclear TAZ/YAP also cooperate with TGFbeta signaling to promote phenotypic and transcriptional changes in nontumorigenic cells to overcome TGFbeta-repressive effects., results suggest that the relationship between plasma TGF-beta1 expression and the development of allograft nephropathy remains uncertain, Studies indicate that transforming growth factor-beta (TGF-beta) is not only produced by T cells, but also regulates T cell responses., Data indicate that transforming growth factor-beta (TGF-beta) is not only produced by T cells, but also regulates T cell responses., Id-1, a protein repressed by miR-29b, facilitates TGFbeta1-induced EMT in human ovarian cancer cells and represents a promising therapeutic target for treating ovarian cancer., Human tumor-infiltrating CD4+CD69+ T cells suppress T cell proliferation via membarene -bound TGF-beta-1., mitotic asynchrony is not only associated with but is also causative of TGF-beta1 secretion in airway epithelium, It is apparent that patients with periodontitis display altered immune responses. Among the inflammatory mediators analyzed in this study, TGF-beta1 levels were consistently elevated in patients., inducing eosinophils into the outer membrane and resulting in elevation of TGF-beta with the Smad pathway activated by TGF-beta, Collectively these data unveil that FBXL19 functions as an antagonist of Rac3 by regulating its stability and regulates the TGFbeta1-induced E-cadherin down-regulation., CD34+ cells cultured under hypoxic conditions secreted high levels of latent TGFbeta., it could be possible that TGF-beta1 plays a role in the formation of fibrous capsule in ChRCCs., Recipient TGFB1 high producer haplotypes were significantly associated with an increased risk for acute rejection in solid organ transplant recipients, particularly patients receiving cardiac allograft., The mechanism for MMP-9 regulation of collagen gel contraction is mediated through the generation of active TGF-B1., TGFbeta signaling regulates miR373, which promotes mesendoderm differentiation in human embryonic stem cells, REVIEW, The results suggest that the expression level of TGF-b1 and a-SMA in stromal fibroblasts may have prognostic significance in patients with clinical stage I-IIIA NSCLC after curative resection, results suggest that TGF-beta1 may be a key promigratory factor in recruiting MSCs to the airways, The data suggest that the balance of TGFA and TGFbeta(1) expression, and to a lesser extend TGFA alone, in the normal-appearing rectal mucosa may be directly associated with risk for incident, sporadic colorectal neoplasms., Demonstrate that Mkk4 is a negative regulator of the TGF-beta1 signaling associated with atrial remodeling and arrhythmogenesis with age., We found that seprase is transcriptionally up-regulated in invasive melanoma cells via the canonical TGF-beta signaling pathway, supporting the roles of both TGF-beta and seprase in tumor invasion and metastasis., NEDD9 regulates epithelial-mesenchmal transition and cell invasion in prostate cancer cells induced by TGF-beta., Plasma TGF-beta1 and TGF-beta1 secretion in dermal fibroblast cell lines were increased in subjects with fibromuscular dysplasia compared to age- and gender-matched controls., Fetal and adult human skin fibroblasts retain their differential proliferative response to TGF-beta when cultured in the presence of fibronectin and unpolymerized or polymerized collagen., The CC genotype and the C allele of TGF-beta1 might be a specific risk factor of ACS in the Chinese Han population., cagocel lead to an increase of IL-4 (p > 0.05), IL-2, IFN-gamma (p < 0.05) and decrease of TGF-beta and IL-12 (p < 0.05). At the same time basic therapy facilitated a significant increase of IL-5 and decrease of IL-6, IL-12, IFN-gamma., Analysis of the mechanism regulating this interplay identified a new transcriptional complex including GLI1 and the TGFbeta-regulated transcription factor, SMAD4., Serum TGFB1 level is elevated in breast cancer patients and has a favorable prognostic value., genetic polymorphism is associated with Graves' disease in Turkey, Moreover, the upregulated miR-21 by nicotine promoted EMT transforming growth factor beta (TGF-beta) dependently, Data indicate that advanced glycation end product 3 (AGE3) increased the expression of TGF-beta mRNA and protein stromal ST2 cells and human mesenchymal stem cells., Human TGFb1 contribute to Staphylococcus epidermidis biofilm formation in lung cancer., We identify that TGFb1-related miR-143, miR-145, miR-146a, and miR-199a may have a key role in the development of prostate cancer metastasis and the restoration of their expression may be a promising therapeutic strategy for PC treatment., HIF1A may regulate some of the gene expression and biological behavior of TGFbeta1 pathway-expressing melanoma cells, in part via alterations in miR-210, miR-218, miR-224, and miR-452, demonstrated a key role of IL-1beta and TGF-beta in the disappearance of occludin at cellular border in placentas with chorioamnionitis, long noncoding RNA activated by TGF-beta was upregulated in hepatocellular carcinoma metastases and associated with poor prognosis., TGFB1 signaling is differentially regulated in aneurysmal tissue and may play a causative role in the development of abdominal aortic aneurysms., These results suggest that ZNF580 mediates eNOS expression and endothelial cell migration/proliferation via the TGF-b1/ALK5/Smad2 pathway, and thus plays a crucial role in vascular endothelial cells., serum levels of TGF-beta1 have diagnostic, predictive, and possible prognostic roles in melanoma patients., enhanced TGF-beta1 expression in nonparenchymal liver cells in autoimmune hepatitis and primary biliary cirrhosis with liver cirrhosis confirms the role of this cytokine in development of fibrosis in autoimmune liver diseases., HGF and TGF-beta are critical regulators for both tumor-stroma interaction and tumor invasion., Dysregulation of transforming growth factor beta signaling, including overexpression of bone morphogenetic protein 4, may lead to a chondrocyte phenotype and may contribute to bony hypertrophy in oligoarticular juvenile idiopathic arthritis., report identifies PARP1 as a novel modulator of two UHRF1-regulated heterochromatin-associated events, The aim of this study was to determine whether TGF-beta induces a "Warburg-like" effect in peritoneal endometriosis., This study suggests that reduced MIR130A is involved in ITP via targeting of TGFB1 and IL18 expression., PAX6 activates miR-135b to inhibit TGF-b and BMP signaling thereby differentiating hESC toward a neural phenotype., Extracellular matrix proteins expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line., Data indicate that HCV E2 glycoprotein interacts with cellular AIMP1/p43 protein and promotes cell surface expression of membrane glycoproteins gp96 and transforming growth factor beta TGF-beta signaling., No significant differences were detected between the CML group and healthy controls with respect to the distributions and numbers of genotypes and alleles in TNF-alpha, TGF-beta1, IL-10, and IFN-gamma, EGR1, SP1 and KLF6 could be responsible for TGFB1 basal expression, KLF6 appearing specific to atherosclerotic lesions., Tenascin-X promotes activation of latent TGF-beta1 and subsequent epithelial to mesenchymal transition in mammary epithelial cells., Meta-analysis indicates that the TGF-beta 1 869 T>C polymorphism is associated with the risk of preeclampsia., Our results support the earlier findings of A2BP1 and TGFB1 being osteoarthritis susceptibility genes and provide evidence of a possible gene-gene interaction in the genetic influence on hand OA predisposition., They also antagonized the TGF-beta1 induced up-regulation of CTGF and transgelin., The TGFbeta-miR200-MIG6 pathway orchestrates the EMT-associated kinase switch that induces resistance to EGFR inhibitors., a previously unrecognized mechanism for ESM cell contraction that depends on TGF-beta1, its receptors, and PLN., In conclusion, the TT genotype of TGFbeta1 T869C was associated with RA risk in the overall population and Asians., alpha1A-adrenergic receptors are stably expressed and stimulate cell migration and TGF-beta1, IGF-1, hyaluronan and PIP production in human skin fibroblasts., Id-1 and TGF-beta1 played important roles in the progression of gastric cancer, in which Id-1 might act as a downstream mediator of TGF-beta1 signaling through a regulatory mechanism involving N-cadherin and beta-catenin., Significant diurnal variations in platelet counts and TGF-b1 and PDGF-BB levels were not observed in platelet-rich plasma., TGF-beta1 may impair glucocorticoid action through a novel non-canonical signalling mechanism., possibly plays a role in the pathogenesis of schistosomiasis-associated pulmonary arterial hypertension, Tumor-suppressive effects of TGF-beta persist in some breast cancer patients at the time of surgery and affect clinical outcome., TGFB1 has roles in early and late breast cancer in apoptosis, tumor progression, higher cell motility, cancer invasiveness, and metastasis [review], Tumor-associated macrophages promote tumor stem cell-like properties via TGF-beta1-induced epithelial-mesenchymal transformation in hepatocellular carcinoma., The TGF-beta/Smad signaling system decreases its activity through strong negative regulation. We provide evidence for a new negative feedback loop through PPM1A upregulation., Report crosstalk between TGF-beta1 and CXCR3 signaling in the regulation of urethral fibrosis., Studies indicate that transforming growth factor beta (TGF-beta) family signaling plays key roles in regulating pluripotency and differentiation of embryonic stem (ES) cells., Data indicate that dachshund family transcription factor 1 (DACH1) suppresses gastric cancer cell proliferation, invasion and metastasis by inhibiting transforming growth factor beta (TGF-beta) signalling pathways both in vitro and in vivo., Study demonstrated that versican, TGFbeta1, Col7A1 and ITGbeta3 are up-regulated in isolated Cancer stem cells., Platelet-rich plasma induces mixed osteogenic/osteoclastogenic phenotype in osteosarcoma SaOS-2 cells, Studies indicate that as an inhibitor of transforming growth factor beta (TGF-beta) signaling, SMAD family member 7 (SMAD7) is overexpressed in numerous cancer types and its abundance is positively correlated to the malignancy., these results suggest that TGF-beta1 plays an important role in colorectal cancer development., The aim of this study was to investigate whether HPSE can modulate the expression and the effects of TGF-beta in tubular cells., Together, these results suggest that p44/WDR77 expression causes the non-sensitivity of proliferating cells to TGFbeta signaling, thereby contributing to cellular proliferation during lung tumorigenesis., Data indicate that concordant transforming growth factor-beta1 (TGFbeta-1) positive and EH-domain containing 1 (EHD1) negative as a strong favorable prognosis factor in non-small cell lung cancer (NSCLC)., An inverse relationship for WISP1 and miR-92a was found in a TGF-beta1 dependent lung fibrosis model in vivo, genetic association study in population in India, The TGFbeta1 induced EDA+ production was dependent on PI3 kinase-AKT signalling and SRp40 expression, This study provided strong evidence supporting the disorganized vascular structures and dysregulation of related molecules in sporadic VMs., The moderate overexpression of TGF-beta1 and TbetaRII mRNA in PTC tissues., TGF-beta1 signaling inhibits beta2-agonist-mediated CFTR activation and subsequent increased epithelial permeability, potentially limiting the ability of beta2-agonists to facilitate paracellular transport in disease states unless TGF-beta1 signaling is inhibited., MCs may play an important role in airway remodeling in asthma as a direct source of PAI-1 and by activating bronchial ECs to produce further PAI-1 via a TGF-beta1-mediated activation pathway., The TGFB1-miR-21-reactive oxygen species pathway of bystander cells has an important mediating role in radiation-induced bystander effects in H1299 cells., Serum IL-17 and IL-23 levels demonstrate no association with type 1 and type 2 diabetes, but, in line with previous studies, TGF-beta levels were lower in type 1 diabetic patients, UV radiation emitted by the solar simulator was able to stimulate the cells from extracellular matrix in in vitro culture to TGF-beta production, MMP-2 and MMP-9 expressions and their mRNAs., genetic association studies in population of women in Iran, study identified 346 proteins involved in renal carcinogenesis and confirmed presence of a metabolic shift in aggressive tumors; TGFBI was overexpressed in tumors with high SSIGN(stage, size, grade and necrosis) scores and significantly associated with oncologic outcomes, data suggest that overexpression of TGF-beta1 positively enhances the proliferation and chondrogenic potential of hSD-MSCs, CGRP-induced cAMP/PKA activation suppresses activation of MAPK induced by TGFbeta1, miR-199a targeted the sequence within the 3'UTR of the N-cadherin mRNA and suppressed the TGF-beta1-induced increase in the protein level of N-cadherin in a manner independent of SNAI1., Results suggest that ezrin is required for epithelial mesenchymal transition(EMT)-induced by TGF-beta1. The interaction of ezrin and PODXL may be important in regulating TGF-beta1-induced EMT., Latent TGFB1 is compartmentalized between blood and seminal plasma of HIV-positive men and its activation in semen is negatively correlated with viral load and immune activation, Studies indicate key role of inhibitory cytokines IL-10 and TGF-beta produced by regulatory T (Treg) cells for the generation of immune tolerance to allergens., data suggest that in epithelial cells stimulated with TGF-beta, early signaling is a mixture of both pro- and antiproliferative signals, whereas later signaling primarily inhibits proliferation., Knockdown of Akt2 using siRNAs or the PI3K inhibitor Ly294002 inhibited TGF-beta1-induced phosphorylation of GSK3beta and expression of Snail1, Oxidative stress is able to induce conversion of endothelial cells into myofibroblasts via TGF-beta secretion., TGF-beta signaling has a role in regulating fibrotic expression and activity in carpal tunnel syndrome, pIgR down-regulation in chronic obstructive pulmonary disease correlates with severity. Bronchial epithelium in vitro retains aberrant imprinting for pIgR expression. pIgR down-regulation is linked to TGF-beta1-driven reprogramming of bronchial epithelium., HOXB9 promotes epithelial-to-mesenchymal transition via TGF-beta1 pathway in hepatocellular carcinoma cells., TGF-beta excess induced a hypothalamic RNA stress response, resulting in accelerated mRNA decay of IkappaBalpha, an inhibitor of proinflammatory nuclear factor-kappaB, TGF-beta and IGF signaling have roles in regulating adjacent stroma cells in prostate cancer development and progression [review], The study identified that the TGF-beta polymorphism could affect the susceptibility to osteosarcoma by increasing TGF-beta expression and found that the serum TGF-beta level was elevated in osteosarcoma patients, especially in those with metastasis., Signatures related to TNFalpha, IL6, and TGFbeta activation pathways are induced within the first hour of retrodifferentiation of hepatocyte-like cells., TGFbeta can induce "BRCAness" in certain breast cancers carrying wild-type BRCA genes and enhance the responsiveness to PARP inhibition., In patients with schistosomiasis japonica, TGF-beta1 participates not only in the inflammatory process, but also in the fibrotic process in which Hsp47 and CTGF probably play a key role., this meta-analysis does not support the hypothesis that TGF-beta1 gene-509C/T polymorphism is a risk factor for the development of IgA nephropathy, High expression of TGF-beta1 is associated with lymphatic metastasis and vaginal recurrence in cervical adenocarcinoma., total serum tsTGF-beta1 is elevated in the entire spectrum of genetic aortic syndromes; however, gradual differences in the increases of tsTGF-beta1 levels may mirror different degrees of alteration of tsTGF-beta1 signaling in different genetic aortic syndromes, microRNA 376c (miR-376c) significantly enhanced neural differentiation of hPSCs in a defined condition by suppressing SMAD4, High TGF-beta1 mediates estrogen receptor-induced epithelial-to-mesenchymal transition in cancer., Influence of TGFB1 C-509T polymorphism on gastric cancer risk associated with TGFB1 expression in the gastric mucosa., This study demonstrates that the C-509T SNP is a significant clinical risk factor for asthma and that the TGF-beta1 cytokine contributes to the progression of the illness., Our data demonstrated that mast cell chymase plays an important role in keloid formation through TGF-beta1/Smad signaling pathway., Vitamin D insufficiency may be a predisposing factor in pemphigus vulgaris with dysregulation of TGFB1/Il-17 ratio., TGF-beta inhibited the expression of NR2F2., these results demonstrate that a cross-talk exists between the TGF-beta1 and SDF-1 pathways in choroid-retinal endothelial cells, tumor cells that expressed high levels of SIX1 could promote lymphangiogenesis and counteract the negative effects of TGFbeta on lymphangiogenesis by increasing the expression of VEGF-C, TGF-beta regulates LARG and GEF-H1 during epithelial-mesenchymal transition to affect stiffening response to force and cell invasion., The p38 signaling pathway mediates the TGF-beta1-induced transdifferentiation of human Tenon fibroblasts to myofibroblasts., A higher frequency to T/A genotype for IFN-gamma and higher frequency of TT GG and TC GG genotype for TGF-beta polymorphism., the present meta-analysis testifies TGF-beta is potently associated with high grade and poor 3 years prognosis of glioma., Those carrying mutant allele of rs1800469 showed 73% increased risk of CAD. Haplotype A-T-T-C-C (alleles in order of rs1800468, rs1800469, rs1800470, rs1800471, rs1800472) associated with a 1.49-fold increased risk., Mutant TGF-beta1 genotypes are significantly associated with MF in Egyptian patients, with the homozygous genotype (T/T) having a stronger association with tumour stage (stage IIb)., PREP1 modulates the cellular sensitivity to TGF-beta by inducing the small mothers against decapentaplegic homolog 3 (SMAD3) nuclear translocation., Overall, our findings demonstrate a novel mechanism, mediated by elevated expression of the miR424-503 cluster, underlying TGFbeta activation and metastasis of human breast cancer., This study sheds light on the role of TGF-b in upregulation of miR143 and the role of miR143 in NSCLC progression, indicating that the target of miR143 expression could be further studied as a novel therapeutic strategy for future control of NSCLC., TGF-beta induced RBL2 expression through down-regulating miR-93 in renal cancer cells, Human embryonic stem cells prevent T-cell activation by suppressing dendritic cells function via TGF-beta signaling pathway, highlights a novel function for epithelial cell adhesion molecule in TGF-beta1-induced epithelial-to-mesenchymal transition process, The expression levels of collagens type I/III, TGF-beta1, Smad2/3/4/7 and PAI-1 (plasminogen activator inhibitor type 1) in gluteal muscle contraction (GMC) patients were measured., The results suggest a novel profibrotic function for IL-17A by enhancing the response of hepatic stellate cells to TGF-beta through activation of the JNK pathway., TGF-beta-mediated suppression of ANT2 through NF1/Smad4 complexes contributes to oxidative stress and DNA damage during induction of cellular senescence., review highlights TGF-beta-induced SMAD-dependent signaling and non-SMAD signaling as the major pathways regulated by TRAF4 involved in breast cancer metastasis, There is a good correlation between serum TGFb1 and IgG N-glycome and its effect on the outcome of entecavir treatment in patients with chronic hepatitis B., Elevated TGFbeta expression is associated with acute lymphoblastic leukaemia., No difference was found in gene expression of TGF-beta1 in placental samples obtained from small for gestational age pregnancies versus normal pregnancy., CD4+ T cells expressing latency-associated peptide and Foxp3 are an activated subgroup of regulatory T cells enriched in patients with colorectal cancer., despite the presence of an activated TGF-b1 expression signature in patients' whole blood, the short dosing duration did not translate into significant antitumor effect in the small number of patients investigated in this study., TGF-beta induced ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion., AMPK inactivation with NOX4-induced ROS formation and transforming growth factor ss-1 (TGFss-1) signaling activation., Mina, a promising biomarker in identifying children who are likely to experience food protein-induced enterocolitis syndrome to milk, FOXQ1 repressed core EMT regulation of the expression of TGF-beta1., The present findings suggest that sustained TGF-beta activation in both ICM and DCM contributes to excess myocardial fibrosis., rs1800471 polymorphism in TGFB1 gene does not have an impact on the development and progression of non-diabetic chronic kidney disease caused by primary glomerulopathy and chronic interstitial nephritis., Fra-1 induces critical changes in the expression of tgfb1 and Epithelial-to-mesenchymal transition transcription factors through direct binding to the tgfb1, zeb1 and zeb2 genomic regulatory regions., CrkL knockdown markedly suppressed the phosphorylated ERK (p-ERK) as well as the phosphorylated AKT (p-AKT) (p < 0.001) compared with control or TGF-b1 alone., this study used immunohistochemical methods to demonstrate the presence of IGF-1, TGF-beta1, and VEGF growth factor receptors in normal, adenomatous, and hyperplastic parathyroid tissue., uPAR has a role in inducing expression of TGFbeta and interleukin-4 in cancer cells to promote tumor-permissive conditioning of macrophages, TGF-beta1 induces nuclear accumulation of RUNX1. TGF-beta1-expressing prostate cancer cells induce hP-MSCs to a myofibroblast differentiation pattern and mediate the reactive stromal response via altered expression of many growth factors and cytokines., Data indicate that downregulation of endothelial NADPH oxidase 4 (Nox4) decreases transforming growth factor beta1 (TGFbeta1)., these data suggest that IL-10 and TGF-beta may modulate FoxP3 expressions at the protein and mRNA levels in respect to their need for peripheral tolerance., High TGFbeta expression is associated with breast cancer., Moreover, the up-regulation of Axl was induced by TGF-beta1, further activated phosphatidylinositol 3-kinase (PI3K)/Akt and PAK1 translocation, and resulted in greater cell motility, invasion, and chemoresistance in vitro and in vivo, SHP2 positively regulates TGFbeta1-induced epithelial-mesenchymal transition modulated by its novel interacting protein Hook1., Overexpression of TGF-b under the conditions applied here also activated the hypertrophic and osteogenic differentiation processes in the treated cells., Novel RNA-binding protein P311 binds eIF3b to promote translation of TGF-beta1, TGF-beta2, TGF-beta3., High TGFB1 protein expression is associated with lymph node metastases in non-small cell lung cancers., Data indicate that influenza A virus H1N1 infection activated alphavbeta6 integrin-dependent transforming growth factor beta (TGFbeta) activity in immortalized bronchial epithelial cells (iHBEC)., ST6GAL1 promotes TGF-beta-dependent epithelial-mesenchymal transition, Donor neutrophil activation and transforming growth factor-beta1 modulation induced by donor apheresis procedures., knockdown of Smad3 significantly reduced TGF-beta1-induced Col.I production. These findings were further evident by the results that overexpression of Smad2 attenuated the expression of Col.I and TIMP-1, The most abundant cytokine present in semen (TGF-beta1) is able to enhance specifically the expression of an important molecule (CD169) involved in the capture and transmission of HIV-1 particles from the mucosal lumen to the submucosal compartment., Down-regulation let-7 by transforming growth factor-beta1-induced Lin28 upregulates collagen expression in glomerular mesangial cells from diabetic mice., A model involving crosstalk of the TGFbeta and Wnt signaling pathways., an Annexin V assay indicated that TGF-b1 resistance in MT-2Rst cells was not directly involved in the acquisition of resistance to apoptosis that is triggered by CB exposure., Transforming growth factor-beta induces microRNA-29b to promote murine alveolar macrophage dysfunction after bone marrow transplantation., These results are formal proof that PD-1 induction through TCR activation on T cells is partially regulated by endogenous TGF-beta., TGF-beta suppression followed by Id4 expression results in extensive melanin synthesis and robust histiocyte recruitment following tumorigenesis, Data show that intracellular levels of tumor necrosis factor (TNF)-alpha and transforming growth factor (TGF)-beta1 in CD34(+) cells treated with vasoactive intestinal polypeptide (VIP) were increased by 50.70 and 43.46%, respectively., Higher levels of TGF-Beta1 are associated with more extensive left atrial fibrosis in atrial fibrillation patients., USP22 may accelerate ovarian cancer cell cycle progression via synergizing with TGFB1 to regulate the TGFB1 downstream cell cycle pathway., HtrA1-mediated LTBP-1 proteolysis prevents its association with fibronectin and the extracellular matrix. Attenuation of TGF-beta signaling caused by a lack of HtrA1-mediated LTBP-1 processing as mechanism underlying CARASIL pathogenesis., The low-cost and easy purification steps allow considering that our proposed preparation of recombinant monomeric TGF-b1 could be employed for in vitro and in vivo experiments as well as for therapeutic intervention., TGF-beta/NKX2.1/PIK3R3 axis is crucial in the TGF-beta-induced inhibition of cell proliferation, and the NKX2.1/PIK3R3 axis might become a target in TGF-beta receptor-repressed lung adenocarcinoma, FOSL2 facilitates TGF-beta1-induced migration by interaction with Smad3 in non-small cell lung cancer.FOSL2 positively regulates TGF-beta1 signalling ., VEGF, PDGF, and TGF-beta1 concentrations in platelets may be associated with prognosis of breast cancer., Crystal structures, mutations and peptide-affinity measurements show that alpahVbeta6 binds with high affinity to a RGDLXXL/I motif within the prodomains of TGF-beta1 and TGF-beta3., increased peritoneal expression of connective tissue growth factor (CCN2), transforming growth factor-beta1, and vascular endothelial growth factor in encapsulating peritoneal sclerosis encapsulating peritoneal sclerosis, Reduced TGF-beta1 expression in lichen planus may participate in immune dysregulation of the disease., Increasing expression of TGF-beta1 protein, decreasing expressions of Ghrelin, Neurexin, and Neuroligin proteins can induce the loss or dysfunction of ganglion cells in distal intestinal canal, the TGF-beta1 C-509 T polymorphism is involved in the etiology of lone AF and thus may be a marker for genetic susceptibility to lone AF and predicting prognosis after catheter ablation in Chinese populations., Taken together, our study provides evidence that TGFbeta receptor signaling-induced EMT may be responsible for the increased PCC invasiveness to enhance its lung metastasis., This meta-analysis suggested that transforming growth factor-beta1 rs1800470 polymorphism was a risk factor of lung cancer., Biglycan upregulates BMP-2 and TGF-beta 1 in human aortic valve cells through Toll-like receptors. Both BMP-2 and TGF-beta 1 are required for aortic valve cell pro-osteogenic reprogramming., results suggest that miR-155 might be involved in the pathogenesis of ITP by regulating cytokine profiles, which may be mediated by miR-155 targeting SOCS1., By visually examining the dynamics behavior, structural basis and energetic property of few typical Abl-drug complex cases, a significantly different pattern of non-bonded interactions between the binding of drug ligands to Abl receptor was revealed., The genetic polymorphism TGF-beta1 +869 C/T may be an independent risk factor for CKD after liver transplantation., the role and mechanism of miR141 in regulating renal fibrosis via the TGFbeta1/miR-141/HIPK2/EMT axis, our findings in this study suggest that PZH can inhibit metastasis of colorectal cancer cells via modulating TGF-beta1/ZEB/miR-200 signaling network, which might be one of the mechanisms whereby PZH exerts its anticancer function, Suggest nuclear NF-AT3 and NF-AT4 participates in atrial structural remodeling, and that PICP and TGF-beta1 levels may be sensitive serum biomarkers to estimate atrial structural remodeling with atrial fibrillation., It is likely that the Smad-independent ERK1/2 pathway regulates Nox4 expression and may be involved in the TGFB1-induced proliferation of endothelial cells, Brachyury plays an important role in regulating TGF beta 1-mediated renal epithelial mesenchymal transition and could be an attractive target for progression of renal disease therapies, The T29C (rs1800470) polymorphism of the transforming growth factor-beta1 gene is associated with restenosis after coronary stenting., There were no significant differences in the distribution of IL-10 and IFN-gamma genotypes between different groups of control and oral precancerous lesions patients but the IL-6, TGF-beta1, and TNF-alpha gene polymorphisms may have a significant association., Data suggest that the tumor necrosis factor-alpha (TNF-alpha)/ transforming growth factor-beta (TGF-beta)/indoleamine 2,3-dioxygenase (IDO) axis may represent a new mechanism contributing to the development of tolerance in IVIg-treated patients., platelet expressed TGF-beta1 may have a role in acute coronary syndrome, TGF-beta1/Smad signaling pathway in human Eca109 ESCC cells might carry similar features as in Kazakh ESCC patients, suggesting that TGF-beta1/Smad signaling pathway might be involved in the regulation of EMT in ethnic Kazakh patients with ESCC, In a healthy adolescent twin cohort, heritability estimates were moderate but significant for transforming growth factor-beta1, 0.57 (95% CI 0.26-0.80)., placental level not significantly reduced in placenta percreta, TGF-beta1 gene expression in the peripheral blood may be used as a molecular marker for the diagnosis of HCC., we show that activated TGFbeta receptor signaling induces apoptosis of pancreatic carcinoma cells in vitro and in vivo, suggesting that activation of TGFb receptor signaling may prevent development of Pancreatic ductal adenocarcinoma., tumoural TGF-beta1 secretion seems to induce nuclear translocation of co-factor FHL2 mediating progressive keratin expression in pilomatricoma., Mechanical stretch upregulated fibronectin and TGF-beta1 expression and activated STAT3 in proximal renal tubular epithelial cells., Thyroid hormones increase airway smooth muscle proliferation and decreases contractile protein expression in the presence of the profibrotic growth factor TGFB1., Identified a novel binding site for c-Jun in the promoter of the Snail1 gene and report that the activation of the TGFbeta-TRAF6-p38 MAPK pathway promotes both c-Jun expression and its activation via p38alpha-dependent phosphorylation of c-Jun at Ser63., Regulatory T cells and TGF-beta1 are increased in clinically localized renal cell carcinoma, A comprehensive meta-analysis of 4 case-control studies was conducted to explore the association between polymorphisms of Msh homeobox 1 (MSX1) and transforming growth factor-beta1 (TGF-beta1) genes and hypodontia., our findings suggest that there might be a CKI-FoxO/Smad-Bim engine in which Thr32 of FoxO3 is pivotal for TGF-b-induced apoptosis, making it a potential therapeutic target for liver cancer treatment., balance between Smad1/5- and Smad2/3-dependent signaling defines the outcome of the effect of TGF-beta on atherosclerosis where Smad1/5 is responsible for proatherogenic effects, miR-424 regulates the myofibroblast differentiation during epithelial-to-mesenchymal transition by potentiating the TGF-beta signaling pathway, likely through Smurf2., MUC1 mediates autocrine TGF-beta signaling by activating the JNK/AP-1 pathway in hepatocellular carcinoma cells., Supporting this idea, we identified a downstream target of the TGFb-miR-96 signaling pathway to be AKT1S1 mRNA, whose translated protein is a negative regulator of mTOR kinase., DRAK1 was predominantly localized in the cytoplasm and bound to Smad3, thereby interrupting Smad3/Smad4 complex formation, which is the core process for the induction of tumor suppressor genes by TGF-beta1, Influenza viral neuraminidase enhances the expression of cellular adhesins through the activation of TGF-beta, leading to increased bacterial loading in the lungs., Authors demonstrated that hepatitis B virus can upregulate the level of Smad7 and inhibit TGF-beta signaling by downregulating miR-15a., study suggests a linear negative association between IL-17 and diabetic kidney disease (DKD) and a positive association between TGF-beta and DKD, Hepatitis B virus transfection could induce TEMT in HK-2 cells, which was mediated by the TGF-beta1/p38 MAPK pathway., We herein present a study to highlight the modulation of the MAPK pathway and the abrogation of the MAPK-regulated TGF-beta/Smad signaling in HepG2 cells by three MAPK-specific inhibitors, Our results suggest that TGF-beta1 up-regulates versican expression by suppressing miR-143, and this pathway is important for osteosarcoma cell migration and invasion., The lack of correlation of interleukin 10 and TGF-b with immune deficits in situ and in vitro suggests re-evaluating their roles in cancer., Mechanisms involved in cochlear extension of otosclerosis are still unclear, but the implication of TGFbeta1 is supported by the present proteomic data and immunostaining results., Role of TGFbeta in regulation of the tumor microenvironment, TGF-beta activates Src in H358 cells largely through a non-canonical redox mechanism., MicroRNA-10a silencing reverses cisplatin resistance in the A549/cisplatin human lung cancer cell line via the transforming growth factor-beta/Smad2/STAT3/STAT5 pathway, Overexpression of TGFbeta1 promotes pulmonary inflammation, apoptosis and mortality via TGFbetaR2 in the developing mouse lung., This is the first report about the association between ADAMTS4 and TGFb1 serum levels in the progression of atherosclerosis in coronary artery disease (CAD). Furthermore, it is seen that TGFb1 haplotype can cause a genetic susceptibility to CAD in the Turkish population., The TGF-b1 gene rs4803457C/T polymorphism is associated with susceptibility to polycystic ovary syndrome (PCOS), and is the key contributor for the development of PCOS in Chinese Han women., Enhanced FHL2 and TGF-beta1 expression is correlated with poor survival in human malignant melanoma, association between TGFB1 29 T --> C transition (rs1800470) and IL6 -572G --> C transversion (rs1800796) with developmental dysplasia of the hip (DDH) and TGF-beta1 and IL-6 interaction in DDH pathogenesis., the elevated serum TGF-beta1 and IL-21 levels could contribute to enhanced Th17 cell differentiation in non-segmental vitiligo., LncRNAs such as lncRNA-HIT ((HOXA transcript induced by TGFbeta) play a pivotal role in EMT and breast cancer progression., TGFbeta1 stimulated Smad-dependent VEGF-A expression, VEGF receptor-mediated EC migration, and capillary-like tube formation, which were all abolished by either PI3K-C2alpha knockdown or a dynamin inhibitor, both TGF-beta and EGF can induce HLA-I downregulation which is then proven to be associated with epithelial-mesenchymal transition in prostate cancer cells., There was no association between TGF-beta gene polymorphisms and juvenile-onset systemic lupus erythematosus in an Iranian cohort., TGFB1 induced miR-155 regulates TP53INP1 expression, epithelial-mesenchymal transition and acquisition of a stem cell phenotype., The TGF-beta1 T869C and TGF-beta1 T29C polymorphisms may be involved in susceptibility to postmenopausal osteoporosis, particular in Asian patients., Our findings afford new insights into the role played by YB-1 in the TGF-beta1 signaling pathway., These results suggest that Wnt5a expressed in PDL tissue plays specific roles in inducing collagen production by PDL cells through TGFbeta1-mediated upregulation of periostin expression., Low-intensity pulsed ultrasound could increase transforming growth factor beta1 and activate extracellular signal-regulated kinase pathway, Selective targeting of this SMAD-independent, p38-MAPK/Cav-1-dependent pathway is likely to be effective in the treatment of pathological conditions characterized by TGF-beta signaling and myofibroblast activation., this study is the first to demonstrate that HG treatment of A549 human lung epithelial cells promotes tumor cell invasion and increases metastasis-associated protein expression by up-regulating HO-1 expression via ROS or the TGF-b1/PI3K/Akt signaling, We found that the recruited macrophages are polarized to a M2 subtype after renal injury. M2 macrophages released high levels TGFb1 to suppress BMP7 to enhance EMT-induced renal fibrosis., The morbidity and metastasis of osteosarcoma are relevant to TGF-b1 gene 29 T > C single nucleotide polymorphism., TGF-beta overproduction is observed in vulvar neoplastic processes., the relationship between serum iron parameters and the levels of TGF-beta, FGF, ET-1, and NO as predictors of chronic liver injury in 54 AHSCT recipients who survived at least a year after transplantation., Data show that in addition to the inhibition of transforming growth factor beta 1 (TGF-beta1) and interleukin 10 (IL-10), bortezomib inhibits mRNA and protein expression of the chemokine receptor CXCR4 in cutaneous T cell lymphoma cells., The present study demonstrated that TGF-beta synthesized by both cancer cells and stromal cells participates in the oral squamous cell carcinoma - induced bone destruction., These data indicated that TGF-beta inhibited IQGAP1 expression in lung fibroblasts via the NF-kappaB signaling pathway, presenting a potential novel therapeutic target for the treatment of idiopathic pulmonary fibrogenesis ., Chemoresistance to doxorubicin induces epithelial-mesenchymal transition via upregulation of TGF-beta signaling in HCT116 colon cancer cells., TGF-beta/Smad2/Smad3 signal pathway is involved in glioma tumor cells proliferation and apoptosis., In summary, we found that AGE-BSA induced EndMT in HUVECs via upregulating TGF-beta and downregulating Sirt 1, which also negatively regulated TGF-beta in the cell., Genetic analysis of two single nucleotide polymorphisms (SNPs) in exon I of the TGF-beta1 gene did not show significant differences between the occurrence of particular polymorphisms and haplotypes in the populations under study, In summary, TGF-beta1 and IL-31 were linked to progression from chronic hepatitis B to liver cirrhosis, and correlated well with the severity of disease., CD105 acts as one of the receptors of TGF-beta1 on vascular endothelial cells and induces the angiogenic pathway in oral squamous cell carcinoma., review of the immune suppressive functions of transforming growth factor-beta [review], single nucleotide polymorphisms show a protective effect under a dominant model of diisocyanate-induced asthma, our findings suggest that TGF-b1 may inhibit the expression of Pokemon, b-catenin, and E-cadherin. The high expression of TGF-b1 leads to an increase in the phenotype and apical-base polarity of epithelial cells, High TGFbeta expression promotes pancreatic ductal adenocarcinoma progression., Three glioblastoma cell lines, SK-MG-1, U251MG and MG178, were tested and CD109 overexpression attenuated TGF-beta1 signaling and enhanced EGF signaling in SK-MG-1, but not in U251MG or MG178., HtrA1 plays a positive role in human periodontal ligament cells osteogenic differentiation and may regulate this process by TGFB1., In prostate cancer, TGF-Beta binding induces epithelial-mesenchymal transition., SIRT1 signaled through a hypoxia-inducible factor-1 alpha (HIF1alpha)-dependent pathway, orchestrating the reciprocal TH1 and T(reg) lineage commitment through DC-derived IL-12 and TGF-beta1., Findings propose that TGFbeta 868 TT genotype and TT/GG diplotype may confer increased risk of brucellosis in the examined population., The results of the current study demonstrated that pro-inflammatory cytokines, including TGF-beta1, IL-1beta and IL-6 exhibited increased expression in human vestibular schwannoma tissue compared with normal vestibular nerve samples, an important attribute of EGF on opposing and reversing Transforming growth factor-beta1 effects, indicating the plasticity of hepatic progenitors, We conclude that TGF-beta influences the pathophysiology of Marfan syndrome. Thus, TGF-beta may be a therapeutic target for preventing MFS-related complications, including cardiovascular diseases and periodontitis., Noncanonical STAT3 activation regulates excess TGF-beta1 and collagen I expression in muscle of stricturing Crohn's disease., TGFbeta1 and TGFbeta2 appeared to play a significant role in physiological and pathological conditions in the fetus., Polymorphisms in TGF-beta1 and IL-10 may have a significant influence on the development of oral cancer., TGFbeta1 induces apoptosis and epithelial-mesenchymal transition in prostate cancer cells via activation of P38-MAPK and Rac1/Pak1 respectively., This study showed a novel SIRT1 mediated protection against renal and retinal injury in diabetes, regulated through p300, ET-1 and TGF-beta1., p53 can both attenuate and cooperate with the TGF-beta pathway to promote cancer cell malignancy in the same cell type, TGFB1 gene may be aging-related gene and involved in Osteoporosis., This study demonistrated that Conversion to MS was associated with marked variability in the expression of proapoptotic genes that were linked to TGF-B1 gene levels, DACH1 inhibits aldosterone secretion in human adrenals, and transforming growth factor-beta signaling pathway is activated in DACH1 overexpressed cells and may mediate inhibition of aldosterone secretion in human adrenals., results suggest that DACH1 loss of function results in increased cell growth, motility and invasiveness through TGF-beta-mediated EMT, and DACH1 loss of function has important therapeutic implications for targeted therapies of CRC, we demonstrated that IGFBP-rP1 suppresses EMT and tumor metastasis by repressing TGF-b-mediated EMT through the Smad signaling cascade., These results support the hypothesis that TGF-b(1)-induced autophagy is required for the fibrogenic response in hATMyofbs., Complement component 3 is up-regulated via non-canonical TGF-beta signaling in the retinal pigment epithelium, TGFbeta-509TT genotype was associated with higher plasma viral load., MicroRNA-152 represses VEGF and TGFbeta1 expressions through post-transcriptional inhibition of prorenin receptor in human retinal endothelial cells., Transforming Growth Factor-beta (TGF-beta) sialylation is involved in Epithelial to Mesenchymal Transition, these results suggest that T869C polymorphism of the TGF-beta1 gene is not associated with SLE disease susceptibility and specific clinical manifestations., this study suggests that TGF-b1 -509C/T and 869T/C polymorphisms are not significantly associated with risk for developing gliomas but may be relevant prognostic biomarkers in GBM patients, hBMP-2 and hTGF-beta1 can synergistically improve the bone repair process. Our results suggest a potential clinical value of combining hBMP-2 and hTGF-beta1 in repairing bone defects., gene expression in human fetal endothelial cells from gestational diabetes in response to TGF-beta1, Our results show that NSCLC patients exhibit high VEGF(PLT) and serum TGF-b1 levels, and VEGF(PLT) and TGF-b1 levels correlate with chemotherapy response to GP regimen., restoring fibulin-3 expression in breast cancer cells inhibited TGF-beta signaling, breast cancer cell EMT, invasion and metastasis in vivo., it was concluded that TGF-beta1, IGF-I/IGF-IR and VEGF-A overexpression is associated with the presence of aggressive tumors, which exhibit an increased probability of metastasis, a poor response to treatment and reduced survival rate., MMP-9 recruitment to the fibroblast cell surface by Lysyl Hydroxylase 3 (LH3) triggers TGF-beta activation and fibroblast differentiation, Serum levels of TGF-beta and TGF-beta mRNA levels from PBMCs did not differ between young and old women. Age affects TGF-beta signalling in leukocytes by altering the expression levels of its receptors., The generation and maintenance of sufficient quantities of active TGF-beta to cause tissue fibrosis in multiple organs probably depends on at least two sources-TGF-beta activation by injured epithelial cells and activated fibroblasts.[review], TGF-beta decreases the stability of IL-18-induced IFN-gamma mRNA through the expression of TGF-beta-induced tristetraprolin in KG-1 cells, emerging concepts pertaining to TGF-beta and downstream signaling pathways in normal HSC biology, featuring aspects of aging, hematologic disease, This study identified that TGF-beta1 +29C/T associated with Vascular Dementia, Platelet activation with a PAR1 agonist triggered TGF-beta secretion, which induced EMT of via the downregulation of miR-200b expression, and activated platelets had a chemotactic effect on colon cancer cells mediated by the upregulation of CXCR4, compromised peroxisome activity might play an important role in the molecular pathogenesis of idiopathic pulmonary fibrosis and fibrosis progression, via TGF-beta signaling., TGFB1 expression is increased in hypoxic bronchial epithelial cells., The combination of local radiation therapy with TGFbeta neutralization offers a novel individualized strategy for vaccinating patients against their tumors., These results suggested that APE1 controls the organization of actin cytoskeleton through the regulation of TGF-beta1 expression, providing novel insights into the biological significance of APE1., TNF-beta C804A polymorphism may be associated with an increased risk of myocardial infarction only in Asian populations. [Meta-analysis], This study shows that TGF-alpha uses common and divergent molecular mediators to regulate E-cadherin expression and cell invasion., Results conclude that TGF-beta1 (rs1800470) may increase the risk of both ESRD and T2D in both populations, but TGF-beta1 (rs1800469) provided risk for only ESRD in the population of Jammu and Kashmir., TGF-beta activates miR-1269 via Sox4, while miR-1269a enhances TGF-beta signalling by targeting Smad7 and HOXD10, hence forming a positive feedback loop., knockdown of TMEM45A also inhibited cell adhesion as well as cell invasion. More importantly, suppression of TMEM45A notably downregulated the expression of TGF-b1, TGF-b2, RhoA and ROCK2., miR-21 regulates cell proliferation, apoptosis, and differentiation in orbital fibroblasts from thyroid-associated ophthalmopathy patients, and acts as a mediator in TGF-beta1-induced collagen production., TGF-beta1 and ELF protein are potential and reliable biomarkers for predicting prognosis in HCC patients after hepatic resection., LIF/p21 signaling cascade as a novel tumor suppressive-like pathway in melanoma, acting downstream of TGFbeta to regulate cell cycle arrest and cell death, further highlight new potential therapeutic strategies for the treatment of cutaneous melanoma, Thrombocytopenia may mediate disease severity in malaria through reduced TGF-beta1-mediated regulation of cytokines associated with severe disease., low serum levels in the early phase of hantavirus infection is associated with a severe course of disease, Suggest that the pro-inflammatory cytokine TWEAK and TGF-beta1 have synergistic effects in EMT and may contribute to chronic airway changes and remodeling., the findings of the present study suggest that H2O2 contributes to HUVEC apoptosis by inducing Nox4-dependent ROS aggregation and activating the TGF-beta1/Smad2 signaling pathway., these findings demonstrate that syntenin may act as an important positive regulator of TGF-b signaling by regulating caveolin-1-mediated internalization of TbRI; thus, providing a novel function for syntenin that is linked to cancer progression., Results suggest that changes in expression levels of EGF and TGFbeta1 resulting from functional polymorphisms, may contribute to an homeostasis disequilibrium and thus to a higher risk for an earlier disease progression of renal Cell Carcinoma ., We wished to determine whether profibrotic transforming growth factor beta 1 and activin A and their downstream signaling proteins are increased in chronic rhinosinusitis with nasal polyps and are regulated in epithelial cells by noxious stimuli., our study does not support a role for TGF-beta1 and VEGF in causing cancer among transplant recipients treated with CNIs., TGF-beta levels are a useful tool for differentiating influenza A (H1N1)pdm09 from other causes of pneumonia progressing to sepsis., expression of TGF-beta1 but not TGF-beta2 is significantly increased in papillary thyroid cancer compared to benign thyroid nodules., genome-wide expression profiling revealed that, in gingival fibroblasts, (5Z)-7-Oxozeaenol reduces the ability of TGFbeta1 to induce mRNA expression of essentially all TGFbeta1-responsive genes (139/147), TGF-beta1 gene C509T polymorphism might be associated with decreased risk of lung adenocarcinoma in Chinese females exposed to cooking oil fumes, but no association was observed TGFBR2 gene G875A polymorphism, Polymorphisms in TGFB1 gene is related to risk of developing inhibitor, and could contribute to a genetic profile of the individual HA for the risk of inhibitors development to FVIII., Serum TGFB1 was increased in T2DM patients compared to controls, and in patients with diabetic nephropathy, compared to diabetic patients without nephropathy. TGFB1 increased with nephropathy severity., TGF-beta 1 increases SERT cellular trafficking in 3D culture of Caco-2 cells., Study shows the stimulatory effect of TGF-beta1 on CTGF expression in human granulosa cells and provide increase the understanding of the normal physiological roles of TGF-beta1 in the ovary., our findings suggest that Ski represses TGF-b-induced EMT and invasion by inhibiting SMAD-dependent signaling in non-small cell lung cancer, discuss how the actions of TGF-betas and BMPs on cancer stem cells may explain their effects on tumor progression, and try to highlight intricate mechanisms that may link tumor cell differentiation to invasion, TGF-beta1 promoted CCL21 expression in lymphatic endothelial cells. CCL21 acted in a paracrine fashion to mediate chemotactic migration of EMT cells toward lymphatic endothelial cells., STAT3 acts as a mediator that synergizes TGF-beta and Ras signals, Data suggest that the transforming growth factor-b1 (TGFB1) rs1800469 polymorphism may be predictive biomarker for the risk of developing brain metastasis in non-small cell lung cancer patients., TGF-beta1 polymorphism 509 C>T is associated with the risk of hepatocellular carcinoma in HCV-infected patients., Study suggests that Rictor/mTORC2 signaling activation mediates TGFbeta1-induced fibroblast activation and contributes to the development of kidney fibrosis., ncreased TGFB1 expression and decreased TIMP-4 expression correlated with atrial fibrosis and extracellular matrix changes in the atria of rheumatic heart disease patients with atrial fibrillation., These findings uncover a plausible mechanism for NF-kappaB-sustained TGF-beta/Smad activation via miR-148a in glioblastoma., The TGF-beta level is higher in HCM patients and associated with a poor prognosis in HCM., High pretreatment serum TGF-beta1 levels were associated with poor prognoses, and increased serum TGF-b1 levels were associated with the disease progression of advanced hepatocellular carcinoma patients., These results suggest fundamental differences in the dominant pathogenic mechanisms underlying Marfan syndrome , stiff skin syndrome and the acromelic dysplasias, which give rise to TGFbeta dysregulation associated with these diseases., MTHFR, TGFbeta1, and TNFB polymorphisms are not significantly associated with the risk of osteoporosis in rheumatoid arthritis., IFNgamma induces oxidative stress, DNA damage and tumor cell senescence via TGFbeta/SMAD signaling-dependent induction of Nox4 and suppression of ANT2, There was no correlation between TGF-beta1 levels and HBV load, but there is a positive correlation between sFas levels and HBV load., the direct CD40-CD40L interaction of breast tumor cells and activated T cells increases TGF-beta production and the differentiation of Th17 cells, which promotes the proliferation of breast cancer cells, IGF-II, TGF-beta1 and VEGF-A and its receptor in malignant tumor tissue, as well as increasedplasmin release from proenzyme and MMP-3 activationis apparently associated with the formation of pathogenic mechanism of vasculature development, role for mTORC2 in mediating TGF-beta/Activin signalling activities, Data suggest Maid/Ccndbp1 inhibits cell migration induced by TGFB1 (transforming growth factor-beta1) but not by BMP4 (bone morphogenetic protein-4); Maid does not alter cell proliferation, epithelial-mesenchymal transition, or TGFB3-induced apoptosis., TGF-beta1 induces epithelial-mesenchymal transition by the transactivation of epidermal growth factor signaling through Hyaluronan/CD44 in lung and breast cancer cells., The results show that esophageal cancer-derived microvesicles are LAMP1 positive and carry MMP9., these findings suggest that TGF-beta suppression and EPO stimulation promote erythropoiesis of CD34(+)CD31(+) progenitor cells derived from hPSCs., TGF-beta downregulates KLRG1 expression in mouse and human CD8(+) T cells., These findings indicate that periostin is an important mediator of TGF-beta-induced epithelial mesenchymal transition., We also found that TGF-beta1 exposure modulates 8 chemokines and 18 cytokines, including TGF-beta1 and -beta2, and other important cytokines, In this study of the Chinese population, homozygosity of TGFB1 rs1800469-T and AGTR1 rs12695895-T might be associated with increased risk of abdominal aortic aneurysm, MAOA T941G and TNF-beta G252A gene polymorphisms appear to contribute to photophobia but not to osmophobia, TGF-beta1-induced hair follicle outer root sheath keratinocytes (ORSKs) and normal skin epithelial cells underwent EMT in vitro with ORSKs exhibiting more obvious EMT changes, studies indicate that VEPH1 inhibits TGF-beta signaling by impeding the release of activated SMAD2 from TbetaRI and may modulate TGF-beta signaling during development and cancer initiation or progression, HGF and TGFbeta1 of bone-metastasis microenvironment acted co-ordinately, influencing non redundant pathways regulated by Twist program or Snail-transcription factor, with reversible MET switch, Histone acetyltransferase inhibitor C646 reverses epithelial to mesenchymal transition of human peritoneal mesothelial cells via blocking TGF-beta1/Smad3 signaling pathway in vitro., Review/Meta-analysis, the TGFB1 c.29C>T polymorphism significantly increases the risk of bladder cancer while c.74G>C, and +140A>G polymorphisms do not affect the same., The T869C polymorphism in the TGFbeta1 gene is not associated with the pathogenesis of polycystic ovary syndrome., Data indicate the transforming growth factor beta (TGFbeta) signaling pathway as a downstream effector of integrin beta-like 1 (ITGBL1) and the transcription factor Runx2 as an upstream activator of ITGBL1 expression., Our findings suggest that TGF-beta1 and IL-10 polymorphisms are involved in complications and comorbidities in type 2 diabetes patients., Frequency of the CC genotype at the TGFB/codon 10 (rs1982037) was underrepresented in febrile seizures patients compared to controls; TGFB at codon 25 (rs1800471) had no significant difference in allele frequencies between our patients and controls, SET and MYND domain-containing protein 3 expression and TGF-beta1 expression in gastric cancer (GC) tissues were significantly and positively correlated. High expression levels of SMYD3 and TGF-beta1 can indicate poor prognoses for GC patients., no relationship was found between TGF-beta concentration and the percentage of Treg cells in peripheral blood and tumors of the ovary, Studied miR-34a expression levels in extrahepatic cholangiocarcinoma; found Smad4 over-expressed in most EHCC patients; activation of miR-34a suppressed invasion and migration through TGF-beta/Smad4 signaling pathway., elevated TGF-beta1 and TGF-beta2 expression triggers invasion and migration by triple-negative breast cancer cells through the EMT process, PDGF and TGFbeta1 regulate acute respiratory distress syndrome-associated lung fibrosis through distinct signaling pathway-mediated activation of fibrosis-related proteins., In donors significantly lower levels of IL-6, TNF-alpha, HGF, and TGF-beta were detected in portal blood compared to hepatic vein In patients with cirrhosis there were no significant differences of IL-6, TNF-alpha, and TGF-beta levels between portal and hepatic veins, Tamoxifen prevents TGF-beta1 mediated myofibroblast differentiation through ERK1/2 signaling pathway., Inhibin betaA is translationally regulated by TGFbeta via hnRNP E1., TGF-beta1 expression was higher in fibrotic liver than that in normal liver. TGF-beta1 protein high expressing liver fibrosis showed alpha-SMA positive cells in the liver indicating activated hepatic stellate cells. TGF-beta1 and alpha-SMA expression were correlated., increased TGF-beta1 concentrations in patients with sporadic DPAA in comparison to the reference subjects show a potential use of TGF-beta1 as a biomarker for the disease, TGF-beta has a role in inducing fibroblast activation and may be involved with the effect of areca nut in oral submucous fibrosis, LAPTM4B binds to GARP and is a negative regulator of TGF-beta1 production in human Tregs, Peripheral endothelin-1 and transforming growth factor-beta1 levels, which strongly correlate with their hepatic levels, reflect the stage of portal hypertension and liver insufficiency in cirrhosis., IL-17A, IL-17F and IL23R polymorphisms have no effect on expression of IL-6, IL-17, IL-21 and TGF-beta1 mRNAs expression in H. pylori-infected gastritis., The cancer-driven alteration of WWP1 culminates in excessive TbetaRI degradation and attenuated TGFbeta1 cytostatic signaling, a consequence that could conceivably confer tumorigenic properties to WWP1., Data show that sorafenib inhibited microRNA miR-101 expression and enhanced dual specificity phosphatase 1 (DUSP1) expression and lowered transforming growth factor beta I (TGF-beta) release in M2 macrophage, slowing macrophage-driven hepatocarcinoma., data showed that IkappaB-zeta-deficient T cells had a high capacity for generation of regulatory T cells (Tregs) when T cells were cultured under TGF-beta stimulation in the presence of cytokine-neutralizing antibodies, This investigation revealed a significant influence of TGFB1 C-509T and T869C polymorphisms on the Pre-eclampsia risk in South Indian women., the CCR7 axis mediates TGF-beta1-induced EMT via crosstalk with NF-kappaB signaling, facilitating lymph node metastasis and poorer overall survival in patients with gastric cancer, These data indicate that NF-kappaB/RelA controls a SMAD-independent gene network whose regulation is required for initiation of Type II EMT, Collectively, the data argue that recessive dystrophic epidermolysis bullosa fibrosis is a consequence of a cascade encompassing tissue damage, TGF-beta-mediated inflammation, and matrix remodeling., a mouse model of R124H mutation of human TGFBI causes granular corneal dystrophy type 2, Pathogenesis of intracranial aneurysm is mediated by proinflammatory cytokine TNFA and IFNG and through stochastic regulation of IL10 and TGFB1 by comorbid factors., strong expression of TGF-beta1, IL-1beta and VEGF was evident in the extracellular matrix and in the cytoplasm of fibroblasts and myofibroblasts in Dupuytren's nodular tissues, as compared to control tissues, TGF-beta1 up-regulates Cx43 and increases gap junction intercellular communication activities (GJIC) in human granulosa cells, results suggest overexpression of TbetaRIII receptor restored TGF-beta1 sensitivity in CAL-27 cells, we find mutation-specific differences in the processing of mutant TGFBIp species, which may contribute to the variable phenotypes noted in TGFBI-related dystrophies., PCDH1 and SMAD3 act in a single pathway in asthma susceptibility that affects sensitivity of the airway epithelium to TGF-beta., TGFbeta1-CXCR7 axis may be a prognostic marker and may provide novel targets for combinational therapies to be used in the treatment of advanced lung cancer in the future, Arg25Pro (c.915G>C) polymorphism of TGFB1 gene suggests an association with increased risk for Hashimoto's thyroiditis, Data show that pyrrole-imidazole polyamide targeting transforming growth factor-beta1 (TGF-beta1) gene promoter region regulates the epithelial-mesenchymal transition EMT/MET process in MCF10A cells., Provided a crosstalk between both pathways, Nrf2 and TGF-beta1 mutually promote their tumorigenic potential, a condition manifesting already at an early stage during inflammation induced carcinogenesis of the pancreas., A dynamic alteration in TERT promoter occupancy by Snail and c-Myc is the mechanistic basis for TGF-beta-mediated regulation of TERT., The single nucleotide polymorphisms (SNP) rs1800469 in the TGFbeta1 promoter was found to significantly associate with late radiation effects in African Americans but not whites., The results suggested a novel function for Twist in the promotion of EMT via TGF-b/Smad3 signaling pathway. Thus, Twist constitutes a potential therapeutic target in human cervical cancer., Data show that transforming growth factor beta 1 (TGF-beta1) expression was higher in gastric cancer in absence of Helicobacter pylori infection., SHI reduced TGF-beta1induced collagen production through the ERK/Smad signalling pathway and attenuated TGF-beta1induced cell contraction by downregulating alpha-smooth muscle actin (alphaSMA) expression in the HSFs., Normal human lung epithelial cells inhibit TGF-beta induced myofibroblast differentiation via prostaglandin E2., periostin may function as a novel regulator to modulate hepatic stellate cells activation, potentially by promoting the TGF-beta1/Smad signalling pathway., NS1 interacts with KLF6 and modulates miR-24 expression and TGF-beta, which facilitates respiratory syncytial virus replication., TGFbeta target genes including TGFBI, BAMBI, COL3A1 and SERPINE1 are significantly increased in Diamond Blackfan Anemia induced pluripotent stem cells, Suggest that TGF-beta1/Smad and Wnt/CTNNB1 signaling pathways both contribute to pathological scar formation., Different signaling pathways are involved in osteitis in CRS and are activated by the TGF-beta/Smad signaling pathway in CRSwNP versus the TGF-beta/Smad-independent signaling pathway in CRSsNP., MT has potentiating effect in TGF-beta1-induced EMT, independently of IDO. This nonimmunological effect of MT should be considered if IDO is the target to avoid immune escape in bladder cancer., Activated TGF-beta1 is associated with Aggressiveness of Prostate Cancer., The non-F508del homozygous mutation with TT genotype was associated to lung symptoms. This association was not found in the sub-groups with homozygous F508del. No association was found with the digestive, pancreatic and meconium ileus symptoms., Microarray analysis of gene expression at 8, 24, and 48 hours after SMAD4 expression characterized the regulatory impact of SMAD4 expression in a SMAD4-null pancreatic ductal adenocarcinoma cell line and identified novel targets of TGF-beta signaling., Our study uncovers the PITX2-induced expression of TGFB1/2/3 as well as INHBA genes (p < 0.01) followed by SMAD2/3-dependent TGF-b signalling pathway in ovarian cancer cells, Transforming growth factor beta1 (TGF-beta1)plays important roles in such forms of organ fibrosis as cirrhosis, pulmonary fibrosis, glomerulosclerosis, cardiomyopathy, Crohn's disease, and scleroderma., these findings suggest that TGFbetainduced release of soluble MICA leads to downregulation of NKG2D, thereby preventing NK cellmediated cytotoxicity toward renal proximal tubular epithelial cells in renal IRI, A Short Peptide That Mimics the Binding Domain of TGF-beta1 Presents Potent Anti-Inflammatory Activity., we show for the first time the expression of FAP in activated fibroblasts after MI and its activation by TGFbeta1. Effects of FAP on fibroblast migration and gelatinolytic activity indicate a potential role in cardiac wound healing and remodeling., TGF-beta1 signaling, loss of metabolic homeostasis and chronic low-grade inflammation appear to play important roles in the pathogenesis of fibrosis, along with oxidative stress and down-regulation of the antioxidant system. (Review), We aimed to perform a meta-analysis to evaluate the relationship between TGF-beta1 polymorphisms and the susceptibility to CKD, results provide evidence that TGF-beta1 and IL-10 could play an important role in the downregulation of HLA-I molecules on CeCa cells induced by tumor MSCs, TGF-beta1 pathway activation in nonsyndromic mitral valve prolapse induces valve interstitial cell differentiation into contractile myofibroblasts and is associated with changes in the molecular pattern of the adherens junction., TGF-beta1 rs1800469 TT and rs2241715 TT homozygote genotypes represent the genetic factors underlying familial clustering of liver cancer in Guangxi., HMGB-1, CXCL16, miRNA-30a, and urinary TGF-ss1 were highly expressed in PNS patients and may play important roles in the pathogenesis and development of PNS., MAPK and TGFB[Transforming Growth Factor beta1]/SMAD signaling pathway may be important molecular mechanism underlying the pathogenesis of endometriosis, demonstrated that EAF2 suppresses both TGF-beta-induced G1 cell cycle arrest and TGF-beta-induced cell migration, In summary, this study demonstrates a link between SphK1/sphingosine-1-phosphate and TGF-beta-induced miR-21 in renal tubular epithelial cells., Relationship between Expression of TGF-beta1, Smad2, Smad4 and Prognosis of Patients with Resected Non-small Cell Lung Cancer, Data show that the expression of transforming growth factor beta 1 (TGFB1) was correlated with the expression of SMA- and MAD-related protein 3 (SMAD3) and matrix metalloproteinase-13 (MMP13) in osteoarthritis (OA)-affected cartilage., mitochondrial dysfunction induces EMT through TGF-beta/Smad/Snail signaling via c-Jun/AP-1 activation., Carriers of Tlower allele showed significant short-term decline in cognitive and functional performance, while individuals with CChigher genotype of TGF-beta1 codon 10 T>C remained stable, HoxB7 is associated with tumor metastasis in patients with lung adenocarcinoma and HoxB7 may be implicated in promoting the development of lung adenocarcinoma through activation of the TGF-beta/SMAD3 signaling., The overexpression of TGF-beta1 is associated with the occurrence of thyroid cancer, which can be used as a candidate for the diagnosis and prognosis of thyroid cancer., Relaxin Inhibits High Glucose-Induced Matrix Accumulation in Human Mesangial Cells by Interfering with TGFB1 Production and Mesangial Cells Phenotypic Transition, findings reveal that TGFbeta1 induces a SP1- and SMAD3-dependent recruitment of histone modifying enzymes to the PLOD2 promoter other than the currently known TGFbeta1 downstream co-activators and epigenetic modifications, TGF-beta/Smad signalling pathway and VEGF-A participate in the pathogenesis of sarcoidosis., analysis of TGF-beta isoforms in thirteen types of cancer, TGF-beta1 induced epigenetic modification of GSN could alter the EMT process in breast cancer cells., Halting pro-survival autophagy by TGF-beta inhibition in bone marrow fibroblasts overcomes bortezomib resistance in multiple myeloma patients., Down-regulation of TGF-b1 is associated with skin lesions., our data not only contribute to clarifying the cellular processes governing pancreatic tissue regeneration, but also emphasize the conserved role of TGFbeta as a tumour suppressor., REVIEW, Regulation of Hyaluronan (HA) Metabolism Mediated by HYBID (Hyaluronan-binding Protein Involved in HA Depolymerization, KIAA1199) and HA Synthases in Growth Factor-stimulated Fibroblasts., Forced overexpression of Wnt7B with or without TGFB1 treatment increased Wnt5A protein expression in normal human smooth muscle cells and fibroblasts but not in Idiopathic Pulmonary Fibrosis myofibroblasts where Wnt5A was already highly expressed., induces the differentiation of CXCL13-producing CD4+ T cells that lack typical follicular helper T cell features, Our results suggest that Gal1 and TGF-beta1 might function coordinately within the HCC microenvironment to regulate tumor growth, invasion, metastasis, and angiogenesis., These results shed new light on the regulation of TGF-beta signaling by Smad7., that miR-449a suppressed Flot2 expression results in decreased cell invasion through repressing TGF-beta-mediated-epithelial-mesenchymal transition, Peritoneal VEGF-A expression is regulated by TGF-beta1 through an ID1 pathway in women with endometriosis, the level of TGFBR1 and early osteogenic differentiation were abolished in the DPSCs transfected with siRNA for GnT-V knockdown...GnT-V plays a critical role in the hexosamine-induced activation of TGF-b signaling and osteogenic differentiation, since GARP functions as a transporter of transforming growth factor beta (TGFbeta), a cytokine with broad pleiotropic traits, GARP transcriptional attenuation by alternative promoters might provide a mechanism regulating peripheral TGFb, NLRC5 regulates TGFB1-induced proliferation and activation of hepatic stellate cells during hepatic fibrosis., Studies indicate crosstalk between Notch receptor and Wnt protein, Hedgehog protein, hypoxia and transforming growth factor beta (TGFbeta)/bone morphogenetic protein (BMP) pathways., Loss of CDKN2B may not only promote cardiovascular disease through the development of atherosclerosis but may also impair TGFbeta signaling and hypoxic neovessel maturation., TGF-beta and PTHrP were confirmed to be involved in regulating the malignant progression in breast cancer, and PTHrP expression, to be associated with bone metastasis as a potential prognostic marker in ER negative breast cancer, The results of this study suggest that TGF-beta1 gene 788C-->T polymorphism is an important factor mediating the casual pathway of preeclampsia., TGFbeta induces autophagy through the pRb/E2F1 pathway and transcriptional activation of autophagy-related genes, TGF-beta could induce HLA-G expression in GC by inhibiting miR-152, involving its negative regulation on HLA-G, elongation of cultured dermal fibroblasts can induce a predominant tenogenic phenotype likely via synergistic effect of TGF-beta and cytoskeletal signaling, Aortic valve endothelial cell derived Tgfb1 signaling promotes nuclear localization of Sox9 in interstitial cells, attenuating aortic valve calcification., pirfenidone may inhibit TGF-beta1-induced extracellular matrix by regulating Smad2/3., that prenatal tracheal occlusion increases TGF-beta/Rho kinase pathway, myofibroblast differentiation, and matrix deposition in neonatal rabbit and human congenital diaphragmatic hernia lungs, The present study thus proposed SEB as an agent able to significantly reduce Smad2/3 expression in colon cancer cells, provoking moderate TGFb growth signaling and the reduction of tumor cell proliferation., Overexpression of miR-1908 suppressed the expressions of TGF-beta1, smad2/3 and MMP-2 in human primary renal interstitial cells., TGFbeta signaling via both SMAD2/7 and PARD6/SMURF1 pathways plays a role in trophoblast growth and differentiation., Our data support a gene-environment interaction between food and genotype at C-509 that modulates disease severity in eosinophilic esophagitis, TGF-beta plays a critical role in initiating expressions of pluripotent transcription factor OCT4 which may contribute to the ectopic endometrial growth., Overall, our study found that miR-181c plays a key role in glioblastoma cell invasion, migration and mesenchymal transition suggesting potential therapeutic applications., correlation between TGFb1 and pSmad2 as well as between HtrA1 and TGFb1 and the very significant increase of Ki67 in stromal compartment of eutopic endometrium suggest a possible involvement of HtrA1 in the pathogenesis of endometriosis., The authors showed that hepatitis C virus E2 protein triggers the production of TGF-beta1 by hepatitis C virus-infected cells through overproduction of glucose-regulated protein 94 (GRP94)., Strongyloidiasis infection is characterized by an IL-10- and TGFbeta dependent expansion of Th9 cells, an expansion found to reversible by anti-helmintic treatment., TGFB1 induces a fibrotic phenotype in lung fibroblasts that is counteracted by targeting the proteoglycan synthesis pathway, In a Chinese population, the TGFB1 gene was found to play a role in the curve progression of patients with adolescent idiopathic scoliosis., TGF-beta/beta2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome., Monocytes increase myofibroblast ECM remodeling via TGFB1 signaling., The results clearly indicated that GRe is the effective constituent in the ginseng on hair promotion via selective inhibition of the hair growth phase transition related signaling pathways, TGF-beta signaling cascades., Plasma levels of IL-10, TGFbeta and IL-17 are significantly correlated with parasite load in Visceral leishmaniasis patients., Although TGF-beta1 signaling in gastric cancer cells appears hyper-activated in i-GC compared to d-GC, the Smad-dependent pathway seems down-regulated while the Smad-independent pathway seems up-regulated in both histologic subtypes., Data suggest novel mechanism in innate immunity allows cytokine TGF-beta to restrict viral circular DNA in hepatocyte nuclei via innate immunity; AID deaminates circular DNA of hepatitis B virus leading to DNA degradation; mechanism depends on UNG., Meta-analysis suggested that elevated serum TGF-beta level in patients with diabetes is associated with a high risk of nephropathy, TGFBIp expression is positively regulated by TGF-beta1 in corneal fibroblasts, whereas TGF-beta1-induced miR-21 and miR-181a negatively regulate TGFBIp expression., LTBP4 protein with the IAAM residues bound more latent TGFbeta compared to the LTBP4 VTTT protein. Its differential avidity for TGFbeta accounting for the differences in TGFbeta signaling attributed to these two alleles., increased expression in alveolar macrophages in Idiopathic pulmonary fibrosis patients, Data indicate that in recurrent spontaneous abortion patients, the expression levels of CD49b and LAG-3 (CD223) on CD14(+) mononuclear cells and the plasma level of transforming growth factor beta (TGF-beta) decreased obviously compared with normal females., In periodontitis, TLR2 gene hyperexpression was accompanied by the reduction of expression of anti-microbial peptide HBD-2, as well as in an increase of production of TNF-alpha and TGF-beta by epithelial cells of periodontium mucosa., These results for the first time demonstrate a role of Cdk5/p35 in the regulation of cell cycle progression modulated by TGF-beta1., data suggest that TGF-beta1 enhances IGFBP7 via Smad2/4 pathways, and that IGFBP7 might be involved in the TGF-beta1-induced tubular injury in DN., a functional conservation of miR-122 in the TGFbeta pathway, is reported., RAGE and TGF-beta1 are both involved in fibrosis development in a complex cross-talk mechanism, while also acting on their own individual targets, high levels of PAI-1 are detected when D allele is present, whereas greater interdialytic gain is associated with the presence of I allele., Pulsed electrical stimulation promotes wound healing by activating skin fibroblasts through the TGFbeta1/ERK/NF-kappaB axis., The results of this study revealed significant predominance of TGF-beta TT (+869) genotype (previously described as predicting low expression activity of TGF-beta) in patients (41.3%) compared to healthy subjects (21.2%., There was a trend to higher fibrosis progression rate in Chronic Hepatitis C patients with mutant alleles and genotypes of TGFb +915 G/C., Urine TGF-beta1 and collagen-IV were significantly higher in albuminuric compared to non-albuminuric participants with HIV infection, High TGFB1 expression is associated with Colon Adenomas., Serum TGF-beta1 in patients with acute myocardial infarction., distribution of the C/T polymorphism of TGFB1 between healthy individuals and patients were obtained as TT, Considering the low frequency of TGF-beta1 G allele at codon 25 as well as TGF-beta1 CT genotype at codon 10 in patients with juvenile idiopathic arthritis, it seems that these cytokine gene polymorphisms could play role as the protective factors against JIA., The involvement of TGF-beta in pathogenesis of Marfan's syndrome permits considering ACE antagonists as potential pharmaceuticals in therapy for this disease. (Review), The maximum risk for Pulmonary tuberculosis is associated with a combination of the AA genotypes of the polymorphic site +874A/Tof the IFNG gene and TT polymorphism G509T of the TGFB gene (AA/TT).,
OMIM_DISEASE Camurati-Engelmann disease, Cystic fibrosis lung disease, modifier of,
SP_COMMENT disease:Defects in TGFB1 are the cause of Camurati-Engelmann disease (CED) [MIM:131300]; also known as progressive diaphyseal dysplasia 1 (DPD1). CED is an autosomal dominant disorder characterized by hyperostosis and sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness and waddling gait, and in some cases other features such as exophthalmos, facial paralysis, hearing difficulties and loss of vision., function:Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts., induction:Activated in vitro at pH below 3.5 and over 12.5., online information:TGF beta-1 entry, polymorphism:In post-menopausal Japanese women, the frequency of Leu-10 is higher in subjects with osteoporosis than in controls., PTM:Glycosylated., PTM:The precursor is cleaved into mature TGF-beta-1 and LAP, which remains non-covalently linked to mature TGF-beta-1 rendering it inactive., similarity:Belongs to the TGF-beta family., subunit:The inactive form consists of a TGFB1 homodimer non-covalently linked to a latency-associated peptide (LAP) homodimer. The inactive complex can contain a latent TGFB1-binding protein. The active form is a homodimer of mature TGFB1; disulfide-linked. Heterodimers of TGFB1/TGFB2 have been found in bone. Interacts with CD109 and DPT., tissue specificity:Highly expressed in bone.,
transforming growth factor beta 2(TGFB2) transforming growth factor beta 2(TGFB2) Related Genes Homo sapiens
CHROMOSOME 1,
CYTOBAND 1q41,
ENSEMBL_GENE_ID ENSG00000092969,
GENERIF_SUMMARY TGFB2 induces MMP-2 expression and suppresses TIMP-2 expression. It promotes invasion of cultured glioma cells in a dose-dependent way., The main source of myofibroblast-like cells and ECM production in the liver is the perisinusoidal stellate cell, which responds to injury with a pleiotypic change termed activation. Activation is orchestrated by cytokines, like tgfb2, no correlation between the concentration of either isoform of TGFbeta in milk and the corresponding TGFbeta in plasma, a transcriptional target for Akt/protein kinase B via forkhead transcription factor., TGF-beta1, TGF-beta2 and TGF-beta3 isoforms are produced by chondrosarcomas and could have a potential role as autocrine growth stimulators in these neoplasms, present in diabetic foot ulcer, Involvement of transforming growth factor-beta2 in catagen induction during the human hair cycle., investigated TGF-beta 1, -beta 2, and -beta 3 latency-associated peptides (LAP)expression in sound and carious human teeth, Immunohistochemical double-staining of human renal sections revealed that most Tgfb2-positive cells in control glomeruli were podocytes with few Tgfb2-positive mesangial cells., TGF-beta2 expression in peritoneal fibroblasts was increased by hypoxia plus TGF-beta1, but decreased by TGF-beta1 alone., Glucocorticoids significantly inhibited TGF-beta1 and TGF-beta2 production and reduced expression of the up-regulated TGF-beta1 and TGF-beta2 mRNA induced by exogenous TGF-beta1, -beta2, or -beta3, Data report the location and level of interleukin (IL)-8 and TGF-beta2 expression in the fimbrial compartment of fallopian tubes and IL-10 expression in the endometrium of women with pyoinflammatory adnexal diseases., All three TGF-beta isoforms have fibrogenic effects on renal cells. TGF-beta2 and TGF-beta3 effects may be partially mediated by TGF-beta1. Blockade of all isoforms together may yield best therapeutic effect in reducing renal fibrosis., Biological dressing effect of cultured epidermal sheets(CESs) is mediated by EGF family, TGF-beta, and VEGF., In the confluent state, TGF-beta1 and TGF-beta2 stimulated the cells to progress to the S-phase of the cell cycle through platelet-derived growth factor-B (PDGF-B) chain production and protein kinase C., increase of serum immunoglobulin A in newborns during 1 month of life was well correlated with levels of both transforming growth factor-beta1 and transforming growth factor-beta2, Repression of promoter activity by HPV type 16 E6 and E7 proteins., PSA-mediated activation of latent TGFbeta2 may be an important mechanism for autocrine TGFbeta regulation in the prostate and may potentially contribute to the formation of osteoblastic lesions in bone metastatic prostate cancer., Recombinant TGF-beta 2 passes through the mouse blood-brain barrier after peripheral injection and is widely distributed throughout the brain, with highest concentrations in the hypothalamus and nerves and lowest in the cerebral hemispheres., upregulation of the potent catagen inducer, transforming growth factor beta2 (TGFbeta2) by BDNF in hair follicles, Human TGF-beta2 but not human TGF-beta1, or -beta3 promotes cardiac myocyte differentiation from mouse ES cells., TGF-beta 2 may promote endometrial tissue repair through the inhibition of the proliferation, expansion, and migration of endometrial stromal cells, and through stimulation of contraction of the collagen gel matrix by these cells., TGF-beta-dependent nuclear accumulation of Smad2 is caused exclusively by selective nuclear trapping of phosphorylated, complexed Smad2, The expression of TGF-beta2 mRNA was higher in cortex cataract than in nuclear cataract., In conclusion, increased TGF-beta2 transcription in response to serum stimulation in KFs appears to be mediated by the p38 MAPK pathway., TGF-beta2 is secreted in response to injury, significantly alters the bulk optical properties of the extracellular matrix, and its tight regulation may be required for normal collagen homeostasis., The mRNA expressions of TGFbeta1 in hMSCs increased with the length of cell culture., ombined effects of TGF-beta2 and connective tissue growth factor appear to be involved in the pathogenesis of proliferative vitreoretinal diseases, The results presented in this paper provide evidence for the involvement of an oxidative process in the apoptosis elicited by TGF-beta(2) in HLECs., BMP-2, TGF-beta2, and TGF-beta3 are involved in bone formation in heterotopic ossifications., No evidence for association with susceptibility or progression of MS, but have demonstrated a trend towards association of the 5' region of the gene with susceptibility to PD., TGF-beta2 triggers the malignant phenotype of high-grade gliomas by induction of migration, and that this effect is, at least in part, mediated by versican V0/V1., These results suggest that FGF-2 suppresses the hMSCs cellular senescence dependent on the length of culture through down-regulation of TGF-beta2 expression., Am-80-induced cell-type non-specific growth inhibition is mediated by TGF-beta2, where the total mass of RARalpha could be an important regulatory factor in hematologic malignant cells, TGF-beta(2) may therefore be involved in the development of childhood atopic asthma by means of functional genetic polymorphism., The highest levels of active TGF-beta2 were found in keratoconus eyes., TGF-beta2 promoted human lens epithelial cell adhesion and migration in vitro. Integrin beta1 and integrin-mediated signaling are necessary for TGF-beta2-promoted adhesion and migration in human lens epithelial cells., TGF-beta2 and -beta3 are differentially expressed during the menstrual cycle and regulated by progesterone in epithelial vs stromal cells., The early induction of TGF-beta1 at the point of SCI suggests a role in the acute inflammatory response and formation of the glial scar, while the later induction of TGF-beta2 may indicate a role in the maintenance of the scar., TGFbeta2 and TbetaRII have roles in the antiestrogenic activity of tamoxifen metabolites in breast cancer, TGF-beta 2 is closely related to cellular differentiation in human developing teeth, TGF-beta 2 was detected since the bud stage of the salivary gland. Its expression was observed in ductal cells and increased along gland differentiation., TGF-beta(2) is a potent growth factor for lens epithelial cell(LEC) epithelial mesenchymal transition(EMT); TGF-beta(2)-induced EMT in LECs is mediated by the downregulation of connexin 43, which is regulated through the PI3K/Akt pathway, The endometria from women with idiopathic infertility TGFbeta2 expression was 2.8 fold higher than in endometria from control group and 2.1 fold higher in endometrial samples from women with unexplained recurrent miscarriage compared to the control group., IL-13 may contribute to subepithelial fibrosis in asthma by stimulating biologically significant TGF-beta2 secretion from the airway epithelium., may affect the growth and differentiation of dental pulp cells via an autocrine fashion by activation of the transforming growth factor beta receptor protein kinase/receptor regulated Smad proteins signal transduction pathways, in gingival crevicular fluid and peri-implant crevicular fluid did not change significantly after a period of de novo plaque accumulation, Taken together, these in vitro and in vivo results indicate that glioma-derived factors may induce MMPs and downregulate endothelial tight junction protein and, thus, play a key role in glioma-induced impairment of the blood-brain barrier., study found different expression of the TGF-beta1, -2 and -3 isoforms in the human corneal epithelium; such differential expression of TGF-betas suggests that each of them may play a specific role in corneal tissue, the TGF-beta1-2-3/Smad3 pathway has a role in mediating ovarian oncogenesis by enhancing metastatic potential, Genes more highly expressed in BRCA1-associated tumors included stathmin, osteopontin, TGFbeta2 and Jagged 1, A dominant increase in TGF-beta2 expression in cord tissue was seen in Dupuytren's disease., BMP4 blocked the TGF-beta2 induction of extracellular matrix proteins in optic nerve head cells; the BMP antagonist gremlin reversed this inhibition, TGF-beta cytokines may be involved in postsurgical adhesion formation, High-affinity binding of TGF-beta1/3 to TGF-betaRII is primarily due to hydrogen bonding between Arg25 and 94 of TGF-beta1/3, and Glu119 and Asp32 of TbetaR-II. Arg25 and 94 are substituted by Lys in TGF-beta2, which binds with low affinity to TbetaR-II., Report expression of decorin in esophageal cancer in relation to the expression of three isoforms of transforming growth factor-beta (TGF-beta1, -beta2, and -beta3) and matrix metalloproteinase-2 activity., Expression levels of Tgfb2 in circulating lymphocytes are not sufficiently specific to diagnose transitory postsurgical complications such as symptomatic infection after liver transplantation., These results suggest an important role for TGF-beta(2) in hair follicle morphogenesis., The TGF-beta2 signal pathway participates in the apoptotic signal transfer and might be an initiator of cellular apoptosis of human lens epithelial cells., Variations of the stress distribution in cancellous bone correlate with the variation of the concentrations of TGF-beta2 and IGF-I in bone matrix., PRDX6 attenuates oxidative stress- and TGFbeta-induced abnormalities of human trabecular meshwork cells., Ladybird homeobox 1 (LBX1), a developmentally regulated homeobox gene, directs expression of the known EMT inducers ZEB1, ZEB2, Snail1, and transforming growth factor beta2 (TGFB2)., Our data provide evidence that TGF-beta signaling patterns vary by age and pathologic features of prognostic significance including ER expression., Data show that TNF-alpha induces the formation of fibrotic foci by cultured retinal pigment epithelial cells through activation of transforming growth factor-TGF-beta signaling in a manner dependent on hyaluronan-CD44-moesin interaction., high prechemotherapy serum levels associated with improved survival in advanced epithelial ovarian cancer, TGF-beta1, TGF-beta2, and TGF-beta3 mRNAs were detected in both normal and pseudophakic bullous keratopathy (PBK) corneas., Carbachol can promote and atropine can inhibit the expression and secretion of TGF-beta2 in human retinal pigment epithelium cells., results represent the first report on CM genetic risk factors in Angolan children and suggest the novel hypothesis that genetic variants of the TGFB2 and HMOX1 genes may contribute to confer a specific risk of developing the CM syndrome, A variant in the fibrillin-3 gene is associated with TGF-beta and inhibin B levels in women with polycystic ovary syndrome., TGF-beta2 suppressed macrophage cytokine production in the developing intestine and protected against inflammatory mucosal injury., elevated levels of TGF-b2 within the anterior segment contribute to the development of glaucoma; the increased risk for developing glaucoma as one ages may in part be related to the rise of this cytokine, The TGF-beta1 mediated secretion of endothelin-1 and TGF-beta2 is mediated by Rho kinase activation in hepatic stellate cells., autocrine stimulation of myeloid progenitors by Tgfbeta2 as one mechanism by which HoxA10 expands this population., Data suggest that glioma stem cells are likely to be the major tumor source of immunosuppressive cytokines such as TGF-beta2 and IL-10 and thereby play a crucial role in determining glioma malignancy., Aqueous humor regulates dendritic cell maturation and function by the combined actions of cortisol and TGF-beta2, a pathway that is likely to contribute to the maintenance of immune privilege in the eye., Study revealed a correlation between the localization of transforming growth factor-beta2 and the development of intraocular hyaloid vascular network, its regression, formation of the vitreous body, and development of definite retinal vessels., quantitative increase in promoter methylation levels of TGFbeta2 is associated with prostate cancer progression, BMP-2 and TGFbeta2 shared pathways regulate endocardial cell transformation, TGFbeta subtypes (1, 2 and 3) affect terminal differentiation of in vitro cultured hBMSCs differently, Degranulation of skin mast cells can be an important mechanism of TGFbeta secretion in systemic sclerosis., Data show that TGF-beta pathways operate during ovarian fetal development, and fibrillin 3 is highly expressed at a critical stage early in developing human and bovine fetal ovaries., differential expression pattern of TGFbeta2 in the lens and retina is correlated with the cell type and differentiation state., The present paper showed that TGF-beta2 stimulates endothelial-mesenchymal transition through multiple signalling pathways., Gremlin employs canonical TGFbeta2/Smad signaling to induce extracellular matrix protein genes and proteins in cultured human trabecular meshwork cells., The present study reveals that TGFbeta2 and NGF are associated with idiopathic epiretinal membranes, suggesting a novel compensatory mechanism so far never proposed., Transforming growth factor-beta2 increases extracellular matrix proteins in optic nerve head cells via activation of the Smad signaling pathway., A total of 853 proteins were quantified. TGFbeta treatment significantly altered the abundance of 47 proteins, 40 of which have not previously been associated with TGFbeta signaling in the eye., Myxomatous mitral valves are characterized by reduced levels of MT1/2 accompanied by an up-regulation of TGF-beta2., The aim of the study was to determine temporal TGFB1, TGFB2 and TGFB3 gene expression profiles in the anterior lens capsule of paediatric patients with posttraumatic cataract., The genotypic and allelic frequencies of transforming growth factor beta 2 gene rs6658835 were associated with VSD (P< 0.05), but not with ASD or PDA (P> 0.05)., identified transforming growth factor-beta2 secreted by normal kidney and ADPKD cells as an inhibitor of cystogenesis in 3D culture system using ADPKD cells from kidneys, RFX1 reduces cell proliferation through inhibiting the TGFbeta2-ERK signaling pathway. RFX1 blocks TGFbeta2 expression through its direct action on TGFbeta2 transcription., data permit us to suggest an important role of TbetaRII expression in the maintenance of chondrocyte phenotype, which is altered with age, and bring new insights in our understanding of chondrogenesis process., TGF-beta2 is abundant in seminal plasma as a key agent in seminal plasma that signals induction of proinflammatory cytokine synthesis in cervical cells., No significant associations were identified between FOXC1, TGFbeta2, and BMP4 alleles and haplotypes and primary open-angle glaucoma., the microenvironment at the verge between inflammation (IL-1beta) and tissue remodeling (TGFbeta2) can strongly promote the process of EndMT., report heterozygous mutations or deletions in the gene encoding the TGF-beta2 ligand for a phenotype within the Loeys-Dietz syndrome spectrum, haploinsufficiency for TGFB2 predisposes to thoracic aortic disease, suggesting that the initial pathway driving disease is decreased cellular TGF-beta2 levels leading to a secondary increase in TGF-beta2 production in the diseased aorta, Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFbeta2 in vascular abnormalization., TGF beta-2 inhibits the expression of the clock genes Period (Per)1, Per2, and Rev-erb-alpha, and of the clock-controlled genes D-site albumin promoter binding protein (Dbp) and thyrotroph embryonic factor (Tef ), TGF-beta may contribute to aneurysm formation by promoting the generation of myofibroblasts that mediate damage to the arterial wall through recruitment of pro-inflammatory cells., TGFbetaRIIb expression is a regulatory mechanism for TGFbeta2 signal transduction., TGFbeta2 protein and localization of mutations are identified in patients with thoracic aortic aneurysm and/or dissection., TGF-beta decreases baseline and IL-13-stimulated mucin production by primary human bronchial epithelial cells., TGF-beta(2) reduces proliferation but stimulates migration of cultured corneal endothelial cells via p38MAPK phosphorylation., SDC-2 modulates TGFbeta2 tra