Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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syndecan 1(SDC1) syndecan 1(SDC1) Related Genes Homo sapiens
CYTOBAND 2p24.1,
GENERIF_SUMMARY The loss of syndecan-1 expression evident in acantholytic conditions, mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma, Serum levels of soluble syndecan-1 correlated with tumor mass in patients with multiple myeloma., Soluble syndecan-1 promotes growth and dissemination of transplanted human myeloma tumors in vivo in SCID mice implanted with human bones., review of structure, function, cell and tissue distribution, regulation of expression in isoform specific manner by farnesoid X receptor, Cells adherent via syndecan-1 do not spread, but can be induced to spread by Mn(2+), suggesting that activation of a beta(1) or beta(3) integrin partner is required., TNF-alpha and IL-1beta are capable of down-regulating syndecan-1 expression, High syndecan-1 expression in breast carcinoma is related to an aggressive phenotype, shedding of syndecan-1 promoted by MT1-MMP through the preferential cleavage of Gly245-Leu246 peptide bond stimulates cell migration, The increased stromal syndecan-1 expression, coupled with its loss from the surface of carcinoma cells, may contribute to tumor cell invasion and the development of metastases, results demonstrate that the laminin alpha3 LG4/5 modules within unprocessed laminin-5 permit its cell binding activity through heparan and chondroitin sulfate chains of syndecan-1, the extracellular domain mediates an interaction that is necessary for dynamic cytoskeletal rearrangements whereas an interaction of the transmembrane domain is required for the initial spreading response, results demonstrate that cell-surface syndecan-1 is a degradative target of heparanase (HPSE-1), and syndecan-1 regulates HPSE-1 biological activity, serves as a primary human papillomavirus receptor protein in natural HPV11 infection of keratinocytes., MT4-MMP and the proteoglycan form of syndecan-1 have roles in ADAMTS-4 activation on the cell surface, Growth-promoting loop exists between breast cancer cells and their stroma that depends on the activity of glycanated Sdc1., Consistent with a possible biochemical role for syndecan-1 in prostate cancer progression and metastasis, syndecan-1 expression correlated with serologic recurrence in Gleason sum 7 prostate cancer and was highly expressed in soft-tissue metastases., in hyperinflammatory lesions, ephrinB2 was predominantly expressed in macrophage-like cells and EphB4 in small venules; syntenin and syndecan-1 were up-regulated in EphB4-positive endothelial cells after stimulation with preclustered ephrinB2, syndecan-1 and glypican-1 have roles in progression of ovarian cancer, Altered matrix-dependent signaling due to increased levels of cell surface syndecan-1 may lead to epithelial cell invasion during early stages of tumorigenesis., Concomitant expression of syndecan-1 in both epithelium and stroma may be a predictor of unfavourable prognosis in breast cancer, and in contrast with previous studies, loss of epithelial syndecan-1 was associated with a more favourable prognosis, syndecan-1 is likely to be a critical regulator of many cellular behaviors that depend on activated alpha(v)beta(3) integrins, constitutive shedding corresponding to the basal level of soluble syndecan-1 ectodomain was significantly increased when cells were stimulated with P. gingivalis lipopolysaccharide, osteoprotegerin affects monocyte mi-gration and protein kinase C and phosphatidylinositol 3-kinase/Akt activation via syndecan-1., syndecan-1 has a role in progression of invasive breast carcinomas through the remodeling of breast cancer tissue via interaction with other extracellular matrix components, Expression of paxillin and syndecan-1 in hepatocellular carcinoma(HCC) may affect its invasive and metastatic ability. May be converse correlation between expression of paxillin and syndecan-1 protein in HCC., Stromal syndecan-1 expression is an independent prognostic marker in pancreatic cancer, whereas epithelial syndecan-1 expression predicts better prognosis only in resectable disease., Loss of syndecan-1 plays a role in the growth of G-type cancers of differentiated type gastric cancers at an early stage, Low epithelial syndecan-1 expression was associated with a higher histological grade and a more advanced clinical stage of the colorectal cancer, Malignant glioma cells express all types of syndecans. NF-kappaB participates in the upregulation of the syndecan-1 expression at the transcriptional level, and increased expression of syndecan-1 could associate with thrombospondin-1., stromal fibroblast-derived Sdc1 stimulates breast carcinoma growth and angiogenesis in vivo, shed syndecan-1 or MMP7-syndecan-1 complexes may have roles in tumor progression, Syndecan-1 and syndecan-4 may have roles in progression of breast carcinoma, The ectodomain of the syndecan-1 core protein contains an active site that assembles into a complex with the alphavbeta5 integrin and regulates alphavbeta5 integrin activity., Certain immunomarkers like syndecan-1, kappa and lambda light chains and IgA heavy chain could be of much help in identifying early stage immunoproliferative small intestinal disease (IPSID)., CD138 may have a role in progression of nodal diffuse large B cell lymphoma, syndecan-1 may have a role in progression of B-cell chronic lymphocytic leukemia, increase of Syndecan-1 in all tissue compartments and a redistribution from epithelium to stroma may be a characteristic feature for dense breast tissue, syndecan-1 shedding may modulate the pathogenesis of specific microbes, the endocytic path taken by Syn-1 is clathrin-independent and relies upon lipid raft function, Lacritin targets the deglycanated core protein of SDC1 and not HS chains or SDC2 or SDC4. Binding requires partial or complete removal of HS chains by endogenous HPSE. This limits lacritin activity to HPSE release sites as an HPSE 'off/on switch'., Syndecan-1 expression is uniquely influenced by changes in the phase and magnitude of the local stress field., domain V of the gamma2 chain negatively regulates the integrin beta4 phosphorylation, probably through a syndecan-1-mediated signaling, leading to enhanced cell adhesion and suppressed cell motility, Heparanase influences expression and shedding of syndecan-1, In summary, ovarian carcinomas exhibit up-regulated expression of several extracellular matrix proteins, and syndecan 1 represents a novel tumor-associated marker in ovarian serous carcinomas., Decreased syndecan-1 is asociated with thyroid cancer, upregulation of syndecan-1 may be a critical element for endometrial cancers in maintaining their viability, SDC1 interaction with the LG4/5 domain in kalinin is essential for keratinocyte migration., syndecan-1 regulates keratinocyte proliferation differently during skin development and in healing wounds., Results indicate a lack of association between SDC-1 polymorphisms and risk of squamous cell carcinomas of the cervix., heparan sulfate and syndecan-1, the predominant intestinal epithelial heparan sulfate proteoglycan, are essential in maintaining intestinal epithelial barrier function., syndecan TMD homodimerization and heterodimerization can be mediated by GxxxG motifs and modulated by sequence context, the association of circulating sCD138 levels in plasma with clinical behavior in 104 patients with chronic lymphocytic leukemia, Syndecan-1 and beta1 integrin signaling downstream of laminin alpha1-derived peptide AG73 regulate adhesion and MMP production by human salivary gland tumor cell lines (CAC2 and M1)., aberrant skin expression may be involved in the development of psoriasis, n-3 polyunsaturated fatty acids (n-3 PUFA) upregulate SDC1 in breast cancer cellsbu activating PPARgamma, providing a chemopreventive effect., In vitro reconstructed normal human epidermis expresses differentiation-related proteoglycans (CD44, syndecan-1, desmosealin, and 7C1)., syndecan 1 is up-regulated by n-3 fatty acids by a transcriptional pathway involving PPARgamma, loss of syndecan-1 epithelial expression was of strong prognostic value in breast carcinomas, Our findings thus suggest that a previously unknown link between integrin alpha2beta1 and syndecan-1 is important in regulating cell adhesion to collagen and in triggering integrin downstream signalling., CD138 is a new simple non-invasive marker for predicting liver fibrosis in patients with chronic hepatitis C., Rab5 is a critical regulator of syndecan-1 shedding that serves as an on-off molecular switch through its alternation between the GDP-bound and GTP-bound forms., Expression of Galectin-3, CD138, p16INK4a, and TTF-1 in mucinous bronchioloalveolar adenocarcinoma after Hodgkin lymphoma., Membrane type 1 matrix metalloproteinase-mediated stromal syndecan-1 shedding stimulates breast carcinoma cell proliferation., syndecan-1 directly contributes to the growth and invasive ability of oral cancer cells, Plasma levels of syndecan-1 increased significantly during coronary artery bypass grafting, with or without the use of cardiopulmonary bypass., Oxidative shedding of syndecan-1 is an underlying cause of neutrophil chemotaxis and aberrant wound healing that may contribute to pulmonary fibrosis., Proteolytic conversion of Sdc1 from a membrane-bound into a soluble molecule marks a switch from a proliferative to an invasive phenotype, with implications for breast cancer diagnostics and potential glycosaminoglycan-based therapies., Data show that syntenin-1 binds to syndecan-1 and participates in the formation of membrane protrusions, and that syntenin-1 recruitment depends on the dephosphorylation of Tyr-309 located within syndecan-1 PDZ binding domain EFYA., Shed syndecan-1 restricts neutrophil elastase from alpha1-antitrypsin in neutrophilic airway inflammation., The active site within the Sdc1 core protein was identified and a peptide inhibitor called synstatin (SSTN) that disrupts Sdc1's interaction with alpha(v)beta(3) and alpha(v)beta(5) integrins was derived., Results show that heparanase alters the level of nuclear syndecan-1., The present results suggest that the decrease in syndecan-1 expression and increase in the Ki-67 index observed in ameloblastic carcinomas is in accordance with its higher aggressiveness as compared to the rare desmoplastic and peripheral ameloblastomas., reduced syndecan-1/E-cadherin expression may be good indicators of recurrence and prognosis in extrahepatic bile duct carcinoma., changes in the pattern expression of syndecan-1 and -2 indicate that both molecules may be involved in the epithelial-mesenchymal transition (EMT) and tumor progression of prostate cancer., syndecan-1 is a co-receptor for APRIL and TACI at the cell surface of MMC, promoting the activation of an APRIL/TACI pathway that induces survival and proliferation in multiple myeloma cells, Results showed that epithelial syndecan-1 expression is reduced as lip carcinogenesis progresses (normal tissue>actinic cheilitis>lip squamous cell carinoma), suggesting that syndecan-1 could be a useful marker of malignant transformation in the lip., Ressutls show that cystic tumors of the pancreas express syndecan-1 and tenascin differently and suggest that low syndecan-1 expression might serve as a predictive factor for malignancy., the effects of syndecan-1 on myeloma survival, growth, and dissemination are due, at least in part, to its positive regulation of tumor-host interactions that generate an environment capable of sustaining robust tumor growth., Study indicates that SDC-1 and -4 may be required for HepG2, Hep3B and Huh7 human hepatoma cell migration, invasion or spreading induced by the chemokine., syndecan 1 and 4 correlate to increased metastatic potential in melanoma patients and are an important component of the Wnt5A autocrine signaling loop, Chronic inflammation and exogenous insulin usage increases the serum syndecan-1 level in type 2 diabetics., syndecan-1 and FGF-2, but not FGFR-1 share a common transport route and co-localize with heparanase in the nucleus, and this transport is mediated by the RMKKK motif in syndecan-1, Data report that the bFGF, FGFR1/2 and syndecan 1-4 expressions are altered in bladder tumours., syndecan-1 might contribute to urothelial carcinoma cell survival and progression, higher proportion of protein-expressing B-cells in the blood of patients with systemic lupus erythematosus, ADAM17 may therefore be an important regulator of syndecan functions on inflamed lung epithelium., Sdc1 has a protective effect during experimental colitis., High CD138 serum levels are associated with B-chronic lymphocytic leukemia progression., Data substantiate the existence of a co-adhesion receptor system in tumor cells, whereby Sdc1 functions as a key regulator of cell motility and cell invasion by modulating RhoA and Rac activity., Age-associated study of detailed characterization of circulating CD138-negative and CD138-positive plasma cells sorted by flow cytometry shows a typical plasma cell cytology with no obvious morphological differences., all syndecans can interact with proteins of the actin-associated cytoskeleton--REVIEW, pathway driven by heparanase expression in myeloma cells, Decreased expression of Syndecan-1 mRNA and the increased expression of HPA-1 mRNA can promote the invasion and metastasis of colorectal cancer., Syndecan-1 shed by tumor cells exerts biologic effects distal to the primary tumor and that it participates in driving osteoclastogenesis and the resulting bone destruction., Syndecan-1 and versican expression status can serve as an indicator of prognosis in patients with epithelial ovarian cancer., Laminin-derived peptide AG73 regulates migration, invasion, and protease activity of human oral squamous cell carcinoma cells through syndecan-1 and beta1 integrin., The presence of a less mature, more resistant CD138-negative myeloma cell fraction within bone marrow microniches might contribute to high incidence of relapse of myeloma patients., Cell biological analysis established that Syndecan1 is a physiological binding partner of Tiam1 and that the PDZ domain has a function in cell-matrix adhesion and cell migration., Expression of syndecan 1 in healthy breast tissue during menstrual cycle., Results suggest a role for syndecan-1 and cathepsins D and K in growth and invasiveness of esophageal squamous cell carcinoma., This study confirms a direct relationship between suprabasal p35 localization together with down-regulation of syndecan-1 immunoexpression and dysplastic changes of oral lichen planus and hence the possibility for malignant transformation., The prognostic value of intraepithelial and stromal CD3-, CD117- and CD138-positive cells in non-small cell lung carcinoma., The syndecan- and alpha2beta1 integrin-binding peptides synergistically affect cells and accelerate cell adhesion., multiple regression analysis showed that apolipoprotein A1 was a predictor of serum syndecan-1 levels in subjects with type 2 diabetes, A threshold of greater than six CD138+ metabolically active plasma cells is associated with poor kidney allograft function and survival., Loss of SDC-1 is associated with prostate cancer., couples the insulin-like growth factor-1 receptor to inside-out integrin activation, These results demonstrate that syndecan-1 and syndecan-2 gene silencing by RNA interference reduces HSV-1 entry, plaque formation and facilitates cell survival., SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis, High glucose can decrease the expression of core protein Sydecan-1 and Glypican-1 in cultured human renal glomerular endothelial cells., In benign samples, syndecan-1 was expressed in basal and secretory epithelial cells with basolateral membrane localisation. In prostate cancer samples syndecan 1 was expressed to granular-cytoplasmic localisation., sCD138 may be applicable as a surrogate marker of disease activity., A multiple regression analysis showed that BMI (beta = 0.783, P < 0.000) was a significant predictor of positive syndecan-1 neutrophils in subjects with type 2 diabetes., Extracellular superoxide dismutase protects cardiovascular syndecan-1 from oxidative shedding and prevents from its subsequent induction of fibroblast proliferation., Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion, There was a statistical relationship between syndecan-1 presence in high-grade tumors and absence of syndecan-4, whereas syndecan-4 presence in cases positive for estrogen and progesterone receptor associated with syndecan-1 absence, In conclusion, CD138 expression may constitute an additional aid in the distinction between WM and SMZL., Findings show significant correlations between MMP-2, -9, and syndecan-1 and hemostatic parameters in hematologic malignancies, in contrast, the MMP inhibitors, TIMP1- and -2, were not correlated with any of the hemostatic parameters., Syndecan-1 is up-regulated in BeWo cells during differentiation and its silencing inhibits syncytialization., CD138 may contribute to the differential diagnosis of renal tumors, syndecan-1 regulates mesenchymal tumor cell adhesion and migration, and different domains have differential effects., Heparanase-mediated loss of nuclear syndecan-1 enhances histone acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive tumor phenotype, In trauma patients, high circulating syndecan-1, a marker of endothelial glycocalyx degradation, is associated with inflammation, coagulopathy and increased mortality., These data suggest that plasma based resuscitation preserved endothelial syndecan-1 and maintained endothelial integrity., Syndecan-1 mediates hepatic VLDL turnover in humans as well as in mice and shedding might contribute to hypertriglyceridemia in patients with sepsis., a new role for syndecan-1 in HSV-1 pathogenesis, results suggest that syndecan-1 may contribute to the highly angiogenic phenotype of MMECs by promoting EC proliferation, survival and modulating VEGF-VEGFR-2 signalling, Heparanase and syndecan-1 interplay orchestrates fibroblast growth factor-2-induced epithelial-mesenchymal transition in renal tubular cells., We found increased vascular adhesion protein 1 activity and anchor protein syndecan-1 content in critically ill patients with septic shock, Syndecan-1 expression was increased in tubular epithelial cells in allografts. Increased syndecan-1 in allografts correlated with low proteinuria and serum creatinine, less interstitial inflammation, less tubular atrophy and prolonged graft survival., Syndecan 1 and syndecan 2 are cellular molecules responsible for susceptibility to HTLV-1., Heparan sulfate chains of syndecan-1 regulate ectodomain shedding., Our results demonstrate that syndecan plays a negative role in death receptor-mediated cell death, CD138 reactivity for neoplastic cells in bone is not a definitive marker for plasmacytic origin., the LAMA3 LG45 domain may trigger different signals toward keratinocytes depending on its interaction with syndecan-1 or -4., Placental syndecan-1 expression is associated with premature birth and fetal growth., syndecan-1 is a novel target of the oncomiR miR-10b., We conclude that serum levels of HGF, OPN, and SYN correspond to the activity of MM and might become useful in differentiation of MGUS, asymptomatic MM, and overt/symptomatic form of MM., Data indicate that immune-magnetic CD138-positive cell sorting significantly increased the percentage of abnormal cells identified in FISH analysis of multiple myeloma (MM) samples., study adds new components to the multi-dentate membrane targeting mechanism and highlights the role of N- and C-terminal PDZ extensions of PSD-95/ZO-1 in the regulation of syntenin-1 plasma membrane localization, Mucosal TNF-alpha is overexpressed only in symptomatic diverticular disease, while SD1 and bFGF are already overexpressed in asymptomatic diverticulosis., The loss of syndecan-1 expression in the epithelial cell membrane is associated with tumor cell growth and invasiveness, the increased expression of syndecan-1 at gene and protein levels is correlated with advanced tumor progression and poor outcome in patients with glioma. Syndecan-1 might serve as a potential prognosis predictor of this dismal tumor., Report demonstrates that syndecan-1 enhances malignancy of a mesenchymal tumour cell line, via induction of syndecan-2 expression., observations suggest that low CD138 expression in multiple myeloma cells relates to poor prognosis, immature phenotype and low sensitivity to lenalidomide, Syndecan-1 alters the dynamic exchange of adhesion complex proteins, which in turn regulates migration speed., Novel processed form of syndecan-1 shed from SCC-9 cells plays a role in cell migration, the lung epithelium requires the syndecan-1 transmembrane domain to govern cell migration and is independent from its ability to control cell adhesion via the extracellular domain., Positive expression of BCL-6, CD10, CD138 and MUM-1 was shown in 78%, 61%, 39% and 91% of the cases., findings demonstrate that 15-LOX-1-mediated metabolism of DHA is required for it to upregulate SDC-1 and trigger the signaling pathway that elicits apoptosis in prostate cancer cells, Data indicate that Syndecan-1 silencing had less powerful effect on the transcriptome compared to overexpression., Syndecan-1, a target of miR-10b, inhibits epithelial endometriotic cell invasiveness through down-regulation of metalloproteinase activity and interleukin-6., Sdc-1 silencing promotes increased MDA-MB-231 cell migration via a beta1-integrin-dependent mechanism., IGF1R coupled with Sdc1 is required for activation of the alphaVbeta3 integrin and for VEGFR2 signalling., The DNA methylome of CD138-positive cells from 56 subjects representing premalignant (monoclonal gammopathy of uncertain significance), early, and advanced stages of myeloma, as well as healthy controls, is characterized., SDC1 expression was not different in patients with advanced vs no/limited LBD.A significant positive correlation between gene expression & BM plasma protein levels was observed for SDC1., Targeting of heparanase-modified syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel hybrid binding site that enhances selectivity., Elevation of serum SDC1 is associated with Crohn's disease., The assessment of syndecan-1 and Ki-67 expression in skin biopsies is a helpful tool for differentiating keratoacanthoma and squamous cell carcinoma, Data indicate that desmoplakin (DSP) and cystatin A (CSTA) interaction and insulin-like growth factor 1 (IGF-1), IGF-binding protein 7 (IGFBP7) and syndecan 1 (SDC1) interaction were observed in protein-protein interaction (PPI) network., SDC1 expression is associated with N stage and the status of resection margin involvement in squamous cell carcinoma (SCC) of the tonsil., High syndecan-1 levels in acute myeloid leukemia are associated with bleeding, thrombocytopathy, endothelial cell damage, and leukocytosis., Our studies demonstrates that SDC1 is the major receptor protein for HCV attachment., results indicate that angiogenesis induced by radiotherapy is associated with an MMP-9-miR-494-SDC1 regulatory loop, Through phenotype analysis, non-HAV-specific antibody-secreting cells are found to be Ki-67lowCD138highCD31highCD38high compared with HAV-specific ASCs., Comparative characteristics of the structure and function for syndecan-1 from animal organisms, Results suggest that small subsets of circulating CD30+/CD15+ cells expressing FGF2 and SDC1 represent biomarkers that identify NS-cHL patients who will experience a poor outcome., Data indicate that biochemical markers significantly associated with mesothelioma were hyaluronan, N-ERC/mesothelin and syndecan-1., Data indicate that the CD138int follicular B cells were clearly distinct from plasma cells., Syndecan-1 overexpression is associated with nonluminal subtypes and poor prognosis in advanced breast cancer., Chemotherapy stimulates syndecan-1 shedding, placental expression decreased in pre-eclampsia, independent of labor, gestational age, birthweight centile, SD1 mRNA levels do not differ between resected colon samples of patients with acute colonic diverticulites and ileocolonic Crohn's disease., Transfection of chimeric anti-CD138 gene enhances natural killer cell activation and killing of multiple myeloma cells., Syndecan-1 modulates the cancer stem cell phenotype via regulation of the Wnt and IL-6/STAT3 signaling pathways, It is concluded that increased SNAIL levels in advanced PC are associated with low expression of syndecan 1, Urinary levels and cellular localization of syndecan-1 are associated with differentiation status of patients with bladder cancer., Syndecan-1 (CD138) contributes to prostate cancer progression by stabilizing tumour-initiating cells., Presence of SDC1 in tumor stroma is an independent risk factor for patient survival in bladder cancer, this study revealed a link between miRNA-143 and Syn-1 in the pathogenesis of melanoma., Heptatitis c virus uses apoE-SDC4 interactions to enter hepatoma cells and establish infection., Expression decreased with the decreasing grades of dysplasia. Syndecan-1 can be efficiently used in early detection and diagnosis of oral carcinoma., Data indicate that the extracellular and cytoplasmic domains of syndecans 1/2/3/4 are intrinsically disordered regions., HO-1, S100A4, and SYND1 expressions have prognostic value in primary non-muscle-invasive bladder cancer (NMIBC)., Syndecan 1 mRNA expression did not vary between chronic diverticulitis and Crohn's disease., In DCIS of different nuclear grades, tissue localization of syndecan-1 is significantly divergent, suggesting a specific effect on biology and progression of DCIS., Increased syndecan-1 expression levels may indicate a high degree of differentiation, an early clinical stage and a favorable prognosis of malignant gastric cardiac adenocarcinoma., Elevated levels of soluble CD138/Sdc-1 in older bladder cancer patients and those with muscular invasion sheds some light on the mechanisms of the disease invasion., Syndecan-1 is involved in morphogenesis of the developing tooth crown and cervical loops, andntogether with CK8 and vimentin in differentiation of preameloblasts and preodontoblasts., syndecan-1 in pleural effusions predicted a survival difference for patients with pleural metastatic disease and malignant mesothelioma., syndecan-1(+) cell syncytia and excess GAG production recapitulate elements of the invertebrate encapsulation reaction, itself dependent on insect transglutaminase and glutaminated early response proteins, Sdc1 is required for HER2-mediated activation of the alpha6beta4 integrin in wound healing assays or tumor cell survival., PKC-mediated syndecan-1 downregulation causes loss of cell invasiveness in melanoma cells under anchorage independency, bFGF, SD1 and TNF-alpha are significantly reduced in Crohn's disease patients in deep remission under treatment with anti-TNFalpha, likely as an expression of optimal control of inflammation., syndecan-1 may have a role as a biological and prognostic marker in patients with triple-positive breast carcinomas, The levels of expression of VEGF and syndecan-4 mRNAs were significantly and positively correlated in cartilage explant but not in cultured chondrocytes, High Syndecan-1 expression is associated with chemotherapy resistance in colorectal cancer., High expression of SDC1 is associated with dedifferentiated liposarcoma tumorigenesis., Our study indicates that SDC1 expressed by the bone marrow microenvironment is involved in angiogenesis in MM., A significant association between SDC1 and breast cancer was identified., this work has broad implications beyond myeloma because shed syndecan-1 is present in high levels in many tumor types as well as in other disease states., Syndecan-1 responsive microRNA-126 and 149 regulate cell proliferation in prostate cancer, Serum SDC-1 levels are increased in systemic lupus erythematosus patients with nephritis, indicating that SDC-1 might be a useful serum biomarker for active LN., Syndecan-1 expression is associated with tumor size and EGFR expression in colorectal carcinoma, This paper provides evidence of alternative binding of IL-34 to chondroitin sulphates and syndecan-1 at the cell surface that modulates M-CSFR activation., our findings identify heparanase as a modulator of the syndecan-syntenin-ALIX pathway, fostering endosomal membrane budding and the biogenesis of exosomes by trimming the heparan sulfate chains on syndecans, syndecan-1 has a role in glycocalyx shedding and is increased in patients with end-stage liver disease; ischemia-reperfusion injury during OLT further exacerbates glycocalyx shedding, Sdc-1 may act as a modulator of ESC apoptosis and probably invasion depth as a crucial factor for successful pregnancy., The concentration of syndecan-1, a marker of glycocalyx damage measured during ED admission, is valuable in assessing the risk of developing AKI and in-hospital mortality., Elevated plasma syndecan-1 levels in renal transplantation patients might be interpreted as repair/survival factor related to loss of tubular and endothelial function in transplanted kidneys., Despite presence of the HPV-receptor syndecan-1 in tongue squamous cell carcinoma (TSCC), HPV prefers the tonsillar environment., miR-302a plays a key role in inhibition of ovarian cancer cell proliferation, and enhancing apoptosis by targeting SDC1., SULF1 levels are lower in pleural malignancies compared to benign conditions and inversely correlate with the amounts of syndecan-1, suggesting important roles for syndecan-1 and SULF1 in malignant mesothelioma., HPV16 particles binds to heparan sulfate and syndecan-1 molecules present in the extracellular matrix., demonstrate that HER2 is captured via a site, comprised of amino acids 210-240, in the extracellular domain of human Sdc1, and EGFR is captured via an extracellular site comprised of amino acids 87-131 in human Sdc4, Targeting Syndecan-1, a molecule implicated in the process of vasculogenic mimicry, enhances the therapeutic efficacy of the L19-IL2 immunocytokine in human melanoma xenografts., stromal changes in the expression of SDC-1 may originate from the stroma and contribute to the pathogenesis and metastatic potential of epithelial ovarian carcinoma, miR-145 suppresses syndecan-1 and, by this mechanism, up-regulates stem cell factors and induces cell senescence and differentiation., The new markers were able to identify a clonal CD138-negative population as minimal residual disease in the bone marrow and peripheral blood of MM patients., Syndecan-1 on epithelial tumor cells promotes MIF binding and MIF-mediated cell migration. This may represent a relevant mechanism through which MIF enhances tumor cell motility and metastasis., The results suggest that Sdc1 may modulate fibronectin fibrillogenesis and/or alter cell morphology during ECM production through alphavbeta3 integrin, thereby mediating ECM fiber alignment., The detection of syndecan-1 in endometrial cancer of different clinical and histological stages could be of prognostic value in clinical diagnosis.,
SP_COMMENT function:Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix., similarity:Belongs to the syndecan proteoglycan family., subunit:Interacts with CDCP1.,