Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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ribosomal protein S6 kinase B2(RPS6KB2) ribosomal protein S6 kinase B2(RPS6KB2) Related Genes Homo sapiens
CHROMOSOME 11,
CYTOBAND 11q13.1,
ENSEMBL_GENE_ID ENSG00000175634,
GENERIF_SUMMARY p70 S6 kinase regulates neutrophilic differentiation in HL-60 cells, regulation of nucleocytoplasmic shuttling of S6KbetaII by protein kinase C-mediated phosphorylation, downstream effectors of PI3K, including PKB and p70 S6 kinase, in part mediate cell adhesion, spreading, and microspike formation induced by galectin-8, the PI3K/p70 S6K/c-Myc cascade plays an important role in neutrophilic proliferation in HL-60 cells., These data suggest that activated p70 S6 kinase could mediate an up-regulation of tau translation., p70 ribosomal protein S6 kinase activity was induced by K-Ras in a phosphatidylinositol 3-kinase and mTOR-dependent manner., IFNgamma-activated p70 S6 kinase phosphorylates the 40S S6 ribosomal protein on serines 235/236, to regulate IFNgamma-dependent mRNA translation., S6K2 is active throughout the cell cycle with higher activity in G2 and M phases., heterogeneous ribonucleoprotein F is involved in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway, Dysregulation of S6 kinases contributes to the pathogenesis of human diseases., S6K1 and S6K2 gene amplification was associated with a worse prognosis., Data show that genetic variation in RPS6KA1, RPS6KA2, and PRS6KB2 were associated with risk of developing colon cancer while only genetic variation in RPS6KA2 was associated with altering risk of rectal cancer., Study shows that the two homologues of S6K have distinct effects on Akt activation and cell survivalin breast cancer., S6K2 expression dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis, The p85 S6K1 promotes H2O2-induced cell death via a rapamycin-insensitive mechanism., S6K2 amplification was frequently observed in gastric cancer and was related to a poor prognosis, The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer., discovered that ERBB4 and S6K2 were the direct targets of miR-193a-3p and that PIK3R3 and mTOR were the direct targets of miR-193a-5p in non-small-cell lung cancer, Degradation of Tiam1 by casein kinase 1 and the SCFbetaTrCP ubiquitin ligase controls the duration of mTOR-S6K signaling.,
SP_COMMENT catalytic activity:ATP + a protein = ADP + a phosphoprotein., function:Phosphorylates specifically ribosomal protein S6., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the protein kinase superfamily., similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily., similarity:Contains 1 AGC-kinase C-terminal domain., similarity:Contains 1 protein kinase domain.,