Database for Annotation, Visualization and Integrated Discovery 2.1
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ribosomal protein S6 kinase B1(RPS6KB1) ribosomal protein S6 kinase B1(RPS6KB1) Related Genes Homo sapiens
CHROMOSOME 17,
CYTOBAND 17q23.1,
ENSEMBL_GENE_ID ENSG00000108443,
GENERIF_SUMMARY TF cytoplasmic domain-independent stimulation of protein synthesis via activation of S6 kinase contributes to FVIIa effects in pathophysiology., Cdc2 provides a signal that triggers inactivation of S6K1 in mitosis., both p70S6K and Akt are activated in the majority of human papillary cancer cells, Muscarinic receptors mediate activation of this enzymme in astrocytoma cells, coupled with pi 3-kinase activation., TNF-receptor activation leads to activation of the p70S6K; TRAF4 is a mediator in this TNF-induced signaling pathway; and TRAF4 inhibits Fas-induced apoptosis, transient expression of the wild type Rheb1 or Rheb2 causes activation of p70S6K, while expression of Rheb1D60K mutant results in inhibition of basal level activity of p70S6K, PI3K mediates G(1) progression and cyclin expression through activation of an AKT/mTOR/p70S6K1 signaling pathway in the ovarian cancer cells., the increase in basal phosphorylation of p70S6K upon granulocytic differentiation of myeloid leukemic cells and their responses to GM-CSF that are closely paralleled with tyrosyl phosphorylation of its receptor, Akt and P70S6K phosphorylation and Gadd45 levels are modulated by GPx-1 in tumor cells, autocrine TGFalpha regulates cell adhesion function by multiple signaling pathways via specific phosphorylation sites of S6K in cancer cells, the response of muscle protein synthesis to insulin and amino acid is impaired in elderly humans; a defect in S6K1 pathway activation may be responsible for this alteration, VEGF and HIF-1alpha expression are inhibited by SU5416 through the inhibition of PI3K/AKT/p70S6K1 pathway in ovarian cancer cells, REVIEW, Overexpression of ribosomal protein S6 kinase, 70kDa is associated with liver neoplasms, RSPRR motif interacts with a negative regulator of S6K1 that is normally suppressed by mTOR., Ability of hyperinsulinaemia to increase mTOR/p70 S6K pathway activity and IRS-1/2 serine phosphorylation in a tissue-specific fashion., identified p70 S6 kinase as a major signal transduction pathway activated by OPN-1 during the migratory response in JAR cells, S6 kinase 1 is essential for the control of muscle cytoplasmic volume by Akt and mTOR, interferon alpha has a role in regulating the p70 S6 kinase pathway in chronic myelogenous leukemia cells, Although zinc could induce cell proliferation and cell growth, and increased phosphorylation of neurofilaments, only cell growth appeared to be related to p7056kinase activation., p70S6 kinase is a major effector of mTOR phosphorylation at Ser-2448 in response to both mitogen- and nutrient-derived stimuli, The mainly anti-apoptotic p70S6k signalling is downregulated in cellular and transgenic models of Alzheimer's disease and in peripheral cells of patients, and could contribute to the pathogenesis of the disease., hVps34 is a nutrient-regulated lipid kinase that integrates amino acid and glucose inputs to mTOR and S6K1, These data suggest that PI3K-dependent T389/T229 phosphorylation is limiting in late-phase p70S6K activation by EGF and contributes to the cooperative effect of GPCRs on p70S6K activity and cell growth., S6K1 maneuvers on and off the eukaryotic initiation factor 3 translation initiation complex., mTOR nuclear import is required for its cytoplasmic signaling to S6K1, We conclude that resistance exercise effectively increases the phosphorylation of S6K1 on Thr421/Ser424, which is not associated with a substantial increase in S6 phosphorylation in a fasted state., p70S6K activation induces expression of MMP-9 associated with hepatocyte growth factor-mediated invasion in human ovarian cancer cells, both S6K1 and eukaryotic translation initiation factor 4E binding protein 1 pathways, regulated by TORC1, are required for cell motility, The higher expressions of p-p70S6K was associated with worse outcome in glioblastoma., In the presence of urokinase plasminogen activator, overexpression of ganglioside GM3 paradoxically increases proliferation of carcinoma cells by augmenting ERK-independent p70S6 kinase activation., Inhibition of p70S6K1 activity by its siRNA also decreased cell migration, invasion, and proliferation associated with the induction of p27(KIP1) levels, and with the inhibition of cell cycle-associated proteins., These results suggest that p70S6K1 regulates turnover of HDM2 protein for cancer development., These studies suggest that, through serine phosphorylation, Raptor-mTOR and S6K1 promote the depletion of IRS1 from specific intracellular pools in pathological states of insulin and IGF-I resistance and in lesions associated with tuberous sclerosis., Collectively, these data suggested that acetaldehyde did not adversely affect glucose uptake despite inhibition of insulin signaling cascade at the levels of Akt and mTOR, possibly due to enhanced p70(S6K) phosphorylation., This study demonstrates a novel mechanism of EGF-induced VEGF and HIF-1alpha expression through production of H2O2 and activation of AKT and p70S6K1 in human ovarian cancer cells., S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt, in response to mitogens, PDCD4 was rapidly phosphorylated by protein kinase S6K1 & then degraded by ubiquitin ligase SCF(betaTRCP); it is proposed that regulated degradation of PDCD4 in response to mitogens allows efficient protein synthesis & cell growth, p70 S6 kinase activates PAK1 and contributes to phosphatidylinositol 3-kinase- and ERK-mediated regulation of HCV RNA replication, Monitoring P70(S6K) phosphorylation can help predict and monitor the biological effectiveness of rapamycin in renal transplant recipients with Kaposi sarcoma., ERK cascade regulates motility of hepatocellular carcinoma cells via uPAR production and p70S6K phosphorylation., phosphorylation increased following low-intensity resistance exercise training combined with blood flow restriction, The inhibition of Akt and S6K1 phosphorylation by PRR5 knock down correlates with reduction in the expression level of platelet-derived growth factor receptor beta (PDGFRbeta)., PRAS40 acts downstream of mTORC1 but upstream of its effectors, such as S6K1 and 4E-BP1, AKT amplification and the mTOR/p70S6K1 pathway play an important role in human lung cancer cells acquiring CDDP resistance, HPV16 modifies S6 kinase activation via mechanism, which activates S6 kinase downstream of Akt function., Rapamycin inhibits S6K1-dependent IRS-1 serine phosphorylation, increases IRS-1 protein levels, and promotes association of tyrosine-phosphorylated IRS-1 with PI3K., Data show that URI and PP1gamma are components of an S6K1-regulated mitochondrial pathway dedicated to oppose sustained S6K1 survival signaling and to ensure that the threshold for apoptosis is set based on nutrient and growth factor availability., Cyclin G2 expression is modulated by HER2 signaling through multiple pathways including phosphoinositide 3-kinase, c-jun NH(2)-terminal kinase, and mTOR signaling., SKAR-mediated recruitment of activated S6K1 to newly processed mRNPs serves as a conduit between mTOR checkpoint signaling and the pioneer round of translation when cells exist in conditions supportive of protein synthesis., p70 S6K Thr 389 (ribosomal protein S6 kinase 70kDa polypeptide 1) phosphorylation was attenuated during resistance exercise, Resistance exercise decreases eIF2Bepsilon phosphorylation and potentiates the feeding-induced stimulation of p70S6K1 and rpS6 in young men., Gene silencing of p70S6K by siRNA alters gene expression in two breast cancer cell lines., activation of the Akt-mTOR-p70S6K pathway plays a significant role in HCC progression by promoting neoangiogenesis., The role and molecular mechanism of p70S6K1 in regulating angiogenesis and tumor growth, and angiogenesis., S6K1 directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2., These data suggest that the S6K1/4E-BP1 pathway may play an important role in polyploidization of megakaryocytes., Activation, regulation, and function of S6K1 isoforms was determined in breast cancer., RPS6KB1 regulates estrogen receptor alpha (ERalpha) by phosphorylating it on serine 167, leading to transcriptional activation of ERalpha., a negative correlation (R=-0.73, P<0.0001) between the RPS6 and the VEGFR2 gene, which is consistent as the gene expression and phosphorylation of S6 is inversely regulated., S6K1 plays an important role in the regulation of insulin action on glucose metabolism in skeletal muscle., SCF can cause a MEK1-independent but PI3K-dependent activation of MAPK, and also MEK1-dependent activation of p70 S6 kinase in ovarian cancer cells., Tyrosine kinase receptors and G protein-coupled receptors trigger distinct p70S6K active conformations., Data show that B[a]PDE increases cyclin D1 expression, and activate the PI3-kinase/Akt/MAPK- and p70s6k pathway in Beas-2B bronchial epithelial cells., Data show that everolimus/RAD001 significantly inhibits cell viability in a dose- and time-dependent fashion, and diminishes phosphorylation of Akt downstream targets, mTOR and p70S6K, in human medullary thyroid carcinoma cells., Data report the crystal structures of the kinase domain of p70S6K1 bound to staurosporine in both the unphosphorylated state and in the 3'-phosphoinositide-dependent kinase-1-phosphorylated state in which Thr-252 of the activation loop is phosphorylated., We provide evidence for a previously unrecognized phospholipase C-gamma1 (PLC-gamma1)-controlled mechanism of mTOR/p70S6-kinase activation, Oscillatory shear stress induces osteoblast-like cell proliferation through activation of alpha(v)beta(3) and beta(1) integrins and synergistic interactions of FAK and Shc with PI3K, leading to the modulation of ERK and Akt/mTOR/p70S6K pathways., The results reveal an opposing and uncoupling effect of mTOR and S6K1 in regulating TF expression., High p70S6K is associated with osteosarcoma progression., found that Rictor phosphorylation requires mTOR complex 1 activity and, more specifically, the p70 ribosomal S6 kinase 1 (S6K1)., P(70)S6K activity increased with the increase in the birth weight of the fetus. Insulin can regulate the activities of P(70)S6K in the placenta and earlier nutrient cells., These data indicate that S6K1 is important for the full induction of autophagy in mammals and raise the possibility that some of the beneficial effects of resveratrol are due to modulation of S6K1 activity., Characterizing the expression of PTEN, AKT and pS6 Ser235/236 might be a useful predictive tool for deciding whether to use mTOR inhibitors to treat conjunctiva melanomas., p70s6k phosphorylation is increased during intake of a protein-carbohydrate drink following resistance exercise in the fasted state., BMP-4, TGF-beta1, 5-HT, and ET-1 treatment induced phosphorylation of p70S6K and ribosomal protein S6, and siRNAs against p70S6K and S6 blocked pulmonary artery hypertrophic response., S6K is primarily involved in regulation of cell size, and affects glucose homeostasis, but is dispensable for global protein synthesis, whereas translational efficiency of TOP mRNAs is a determinant of the cellular protein synthesis capacity., IL-8 reverses an mTOR/S6K-led down-regulation of PLD2 expression and enables PLD2 to fully function as a facilitator for cell migration, p70S6K plays an important role in metastasis by regulating key proteins which are essential for cell attachment, survival, invasion, and metastasis in breast cancer., blocking of OPN-induced ICAM-1 expression through mTOR/p70S6 kinase signaling pathway may be an important therapeutic strategy for the treatment of breast cancer., p70S6K1 is required for tumor growth and angiogenesis through HIF-1alpha and VEGF expression, providing a molecular mechanism of human ovarian cancer mediated by p70S6K1 signaling., K516 acetylation may serve to modulate important kinase-independent functions of S6K1 in response to growth factor signalling., when exercise is performed in a fasted state, the increase in phosphorylation of signalling molecules such as p70(S6k) and the S6 ribosomal protein in human muscle depends on the exercise volume, By searching for the kinases responsible for Mdm2 S163 phosphorylation under genotoxic stress, the authors identified S6K1 as a multifaceted regulator of Mdm2., Data indicate that high ErbB2 expression enhances cholangiocarcinoma invasion, motility and proliferation via the AKT/p70S6K pathway., Dysregulation of S6 kinases contributes to the pathogenesis of human diseases., S6K1 and S6K2 gene amplification was associated with a worse prognosis., Erk1/2 MAPK and PI3K/Akt signalling triggers invasion through distinct downstream effectors involving mTOR/p70S6K and Rac1 activation., Data show that genetic variation in RPS6KA1, RPS6KA2, and PRS6KB2 were associated with risk of developing colon cancer while only genetic variation in RPS6KA2 was associated with altering risk of rectal cancer., Data show that the mTOR effectors, 4EBP1, p70S6K and rpS6, are highly activated in cultured and primary FLT3-mutated acute myeloid leukemia (AML) cells., Results suggest that S6-kinases 1 and 2 are dispensable for the induction of SREBP processing., Phosphorylated S6K1 is associated with endocrine therapy resistance in hormone receptor-positive breast cancer., Disruption of adaptive energy metabolism and increased levels of p-S6K1 are contributing factors in infantile neuronal ceroid lipofuscinosis pathogenesis., GSK3beta inactivation in podocytes results in decreased phosphorylation of p70S6K accompanied by cytoskeletal rearrangements and inhibited motility., Results reveal a new direction for understanding the oncogenic roles of p70(S6K) in tumor progression., gestational diabetes mellitus and impaired glucose tolerance subjects had a persistent activation and increased S6K1 phosphorylation compared to subjects with normal glucose tolerance, Findings support a novel link between the IGF pathway and ERalpha, in which the translation factor S6K1 affects transcription of ERalpha-regulated genes., Akt2 specifically targets and activates the p70S6K signaling pathway, Knockdown of SIRT1 abolished GR-induced p16 repression as well as Akt/p70S6K1 activation implying that SIRT1 may affect p16 repression through direct deacetylation effects and indirect regulation of Akt/p70S6K1 signaling., The observations may have practical implications as they raise the possibility to consider p70S6K and/or S6 as a potential therapeutic target-besides mTOR-in certain lymphomas and perhaps in clinical immunosuppression., Studies indicate that the inhibition of mTORC1 by FOXO could lead to the activation of Akt via the inhibition of the negative feedback loop driven by mTORC1 and S6K1., S6K2 expression dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis, A fusion transcript (RPS6KB1-VMP1) recurrently expressed in 30% of breast cancers is associated with clinical consequences and may indicate genomic instability altering the expression of oncogenic components such as MIR21 and RPS6KB1., nSMase2 is a major component of ATRA-induced growth arrest of MCF-7 cells; S6K is a novel downstream target of nSMase2, Data show that the deregulated kinase activities identified, which include the mTOR/p70S6K and ERK1/2 pathways, are potential novel molecular targets in MM., phosphorylation of S6K1 is required for mTOR to phosphorylate the hydrophobic motif of S6K1., Acute manipulation of eccentric exercise velocity does not seem to differently influence intracellular hypertrophy signaling through the Akt/mTORCI/p70S6K pathway., Proper nucleocytoplasmic localization of p70 S6K1 depends on its mTOR-mediated phosphorylation but not on its kinase activity., S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation., Knockdown of PHLPP1 or PHLPP2 resulted in an increase in S6K1 phosphorylation., S6K1 and 4E-BP1 are independent regulated and control cellular growth in bladder cancer, High p70S6K phosphorylation is associated with intrahepatic cholangiocarcinoma., S6K1 directly phosphorylates and regulates ligand-independent activity of ERalpha, while ERalpha upregulates S6K1 expression., the effect of TBC1D3 on IRS-1, Fatty-acid oxidation in response to S6K1 inactivation., An activated mTOR/S6K1 pathway promotes Gli1 transcriptional activity and oncogenic function through S6K1-mediated Gli1 phosphorylation at Ser84, which releases Gli1 from its endogenous inhibitor, SuFu., the role and mechanism of miR-128 in regulating glioma tumor angiogenesis via miR-128/p70S6K1 axis, Together, these observations suggested that hepatitis C virus infection activates the mTOR/S6K1 pathway in inhibiting IRS-1 function and perturbs glucose metabolism via downregulation of GLUT4 and upregulation of PCK2 for insulin resistance., Rapamycin can effectively suppress the proliferation of prostate cancer 22RV1 cells by regulating the expression of S6K1., Our data suggest that RPS6KB1 may play an important role in the progression of hepatocellular carcinoma, in human adipose tissue phosphorylated Threonine in S6K1 is a marker for increased glucose levels, suppression of Jurkat cell proliferation by C. pneumoniae was at least in part mediated by down modulation of protein synthesis through attenuation of Thr389 phosphorylation of p70S6K., High RPS6KB1 expression is associated with ovarian granulosa cell tumor., The nuclear expression of p-mTOR, p-4E-BP1 and p-p70S6K was associated with biological behaviors (invasiveness) of ameloblastomas, and p-mTOR was an independent predictor of them., The p70S6K1 total protein content of quadriceps muscle increased after concurrent strength and interval training., alternative splicing of S6K1 acts as a molecular switch in breast cancer cells, elevating oncogenic isoforms that activate mTORC1., HMGA2 overexpression induced a PI3K/Akt/mTOR/p70S6K cascade, which in turn suppressed the expression of p16(INK4A) and p21(CIP1/WAF1) in human umbilical cord blood-derived stromal cells., HIV+/EBV+ aggressive diffuse large B-cell lymphoma could be potentially treated by targeting RPS6KB1 and CDC2 genes., These findings collectively suggest that S6K1 plays an important role in tumor cell survival under stress conditions, and thus inhibition of S6K1 may be an effective strategy for sensitizing cells to glucose deprivation., No amplification of S6K1 was detected in gastric cancer tissues, Muscle biopsies were collected before and 1 and 3 h post resistance exercise and phosphorylation of mTOR (Ser(2)) increased 2-fold (P < 0.05) and that of S6K1 (Thr(3)) 14-fold (P < 0.05)., The AKT/S6K signaling pathway participates in atrial fibrillation and rheumatic mitral valve disease., Phosphorylation of the hydrophobic motif in S6K1 is independent of, and probably precedes and promotes, phosphorylation of the activation loop., There is an increased genetic risk for multiple sclerosis with the rs180515 single nucleotide polymorphism in RPS6KB1., High phosphorylated RPS6KB1 expression is associated with non- small cell lung cancer., Vascular tumors (both angiosarcomas and capillary infantile hemangiomas) exhibit increased activation of p70-S6K; knockdown of p70-S6K results in reduced tumor cell proliferation and migration., expression of p-S6K1 may be a predictive marker of resistance to neoadjuvant chemotherapy in patients with breast cancer, overexpression of 4EBP1, p70S6K, Akt1 or Akt2 could promote the Coxsackievirus B3-induced apoptosis., H2O2 stimulated phosphorylation of RSK and MSK kinases at residues that are homologous to Thr389 in S6K1. This phosphorylation required the activity of either p38 or ERK MAP kinases., Constitutive mTOR signaling induces the formation of giant cells via phosphorylation of S6K., impaired phosphorylation and ubiquitination by p70S6K and Smurf1 increase the protein stability of TRIB2 in liver cancer, this study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1, functioning as a tumor suppressor., Data indicate that the combined activity of pS6K and elf4E regulates cell proliferatioin, cell migration and invasion in bladder cancer cells., Data indicate that ribosomal S6 kinase 1 (S6K1) is negatively involved in the toll-like receptorS TLR2 and TLR4 signaling pathway by the inhibition of TAK1 (MAP3K7) activity., Estradiol enhances CIP2A expression by the activation of p70 S6 kinase., Ghrelin stimulated the rapid phosphorylation of mammalian target of rapamycin (mTOR), P70S6K and S6., Data suggest that the ribosomal S6 kinase , PKD3 in TNBC cells provides a molecular connection between the Golgi and endolysosomal compartments to enhance proliferative mTORC1-S6K1 signaling., Data indicate that p70 S6 kinase inhibitor LY2584702 treatment was not dose proportional with increasing dose., Patients whose tumor expresses Phosphorylated p70S6K, as a marker of downstream Phosphatidylinositol 3-Kinase and/or Mitogen-Activated Protein Kinase pathway activation, have a favorable prognosis, but do not benefit from adjuvant tamoxifen., Data indicate that p70 S6 inhibitor LY2584702 was not well tolerated when administered with erlotinib., CXCL4 and CXCL4L1 activated p38 MAPK, as well as Src kinase within 30 and 5 min, respectively. Extracellular signal-regulated kinase (ERK) phosphorylation occurred in activated lymphocytes., our data emphasizes the importance of the translational regulation of p21 by the MEK1/2-ERK1/2-p70S6K pathway to negatively control the cell cycle progression., In cells expressing the VPS34-Y231F mutant, which blocks lamellipodia formation, mTOR localization at the plasma membrane and insulin-mediated S6K1 activation are reduced., Blocking PI3K, mTORC2 or p70S6K activity prevents lethal autophagy and decreases infectious virus production., Data indicate that Rheb G63A stimulated phosphorylation of the mTORC1 substrate p70S6 kinase more strongly than wild-type, thus offering a new tool for mammalian target of rapamycin (mTOR) signaling., The acetylation of the CTR of S6K1 is inhibited by the class III histone deacetylases, SIRT1 and SIRT2., p70S6K activity positively contributes to proliferation and invasion of breast cancer cell lines., These studies demonstrated that fisetin inhibits mTOR and p70S6K through direct binding while the observed inhibitory effect of fisetin on AKT is mediated indirectly, through targeting interrelated pathways., S6 kinase inhibition leads to suppression of prostate cancer cell growth and sensitization to paclitaxel., Data indicate that zinc finger protein SNAIL modulates ribosomal protein S6 kinase 1 (RPS6KB1)/HIF-1alpha/protein kinase 2 (PKM2) signaling pathway through miR-128., These results demonstrate that S6K1 and arginase-II form a positive circuit mediating the detrimental effects of chronic L-arginine supplementation on endothelial cells., Our data suggest that RP loss promotes the aberrant activation of both S6 kinase and p53 by increasing intracellular ROS levels, Further experiments demonstrated that phosphatidylinositide 3-kinases/protein kinase B/mammalian target of rapamycin/p70S6 kinase (PI3K/AKT/mTOR/p70S6K) and extracellular regulated protein kinases (ERK)., Rapamycin-enhanced mitomycin C-induced apoptotic death is mediated through the S6K1-Bad-Bak pathway in peritoneal carcinomatosis., our results demonstrate that activation of the PI3K/Akt/mTOR/p70S6K signaling pathway is involved in S100A4-induced viability, migration, upregulation of VEGF and downregulation of E-cadherin in CRC cells., This study provides the first evidence for mTORC1/p70S6K-dependent regulation of pyrimidine biosynthesis in a relevant disease setting., The increased level of S6K1 is positively associated with obesity, insulin resistance and inflammation., Results demonstrate that the impact of S6K1 kinase on neuroblastoma cells is not mediated through modulation of GLI1 expression an the effects of S6K1 and GLI1 signaling on neuroblastoma cell proliferation are mediated through independent mechanisms., Results show that high expression of p70S6K and 4EBP1 proteins may act as valuable independent biomarkers to predict poor prognosis of nasopharyngeal carcinoma patients., S6K1 enhances c-Myc translation efficiency by modulating the phosphorylation of eukaryotic initiation factor eIF4B, which is critical to unwind its structured 5' untranslated region., Data show that the induction of resveratrol-dependent autophagy is mediated via the mechanistic target of Akt proto-oncogene protein/rapamycin complex 1 (mTORC1)/S6 kinase 1 (S6K1) signaling pathway., Data suggest that potent, selective, and cell permeable S6 kinase 1 (S6K1) inhibitors can be prepared with possible therapeutic applications., Resistance to Selumetinib (AZD6244) in colorectal cancer cell lines is mediated by p70S6K and RPS6 activation., pS6 expression is associated with the characteristics of a high Ki-67 subset in ER+ and HER2- breast cancer whose proliferation seemed to be affected by activation possibly of the mTOR/S6 pathway., Arg-II, p38, and S6K1 form a positive circuit which regulates endothelial senescence and cardiovascular aging., Tanshinone IIA inhibits HIF-1alpha and VEGF expression in breast cancer cells via mTOR/p70S6K/RPS6/4E-BP1 signaling pathway., mTORC1 regulates cell adhesion through S6K1 and 4E-BP1 pathways, but mTORC2 regulates cell adhesion via Akt-independent mechanism, A higher SUVmax on 18F-FDG PET is associated with elevated tumor levels of pAkt and pS6 protein and with aggressive behavior and metastatic potential of RCC, as well as with early relapse following radical nephrectomy and shorter overall survival., This is the first study highlighting the activation of S6K1 by palmitic acid as a common and novel mechanism by which its inhibition by oleic acid prevents endoplasmic reticulum stress, lipoapoptosis and insulin resistance in hepatocytes., The newly identified miR-195-RPS6KB1 axis partially illustrates the molecular mechanism of prostate cancer progression and represents a novel potential therapeutic target for prostate cancer treatment., Data show that leucine alone stimulates mTORC1 signaling and ribosomal protein s6 kinase 1 (S6K1) phosphorylation., eIF3 has a role in controlling cell size independently of S6K1-activity, Inactivated Sendai virus induces apoptosis and autophagy via the PI3K/Akt/mTOR/p70S6K pathway in human non-small cell lung cancer cells., MiR-497 decreases cisplatin resistance in ovarian cancer cells by targeting mTOR/P70S6K1., These results indicate that the inhibitory effect of rapamycin may be due mainly to increased p14, p15, and p57 expression via promoter demethylation and decreased mTOR and p70S6K expression in ALL cell lines., Results suggest that blocking both the mTOR kinase downstream targets 4E-BP1 protein and p70 S6 kinase 1, but not p70 S6 kinase 1 alone, prevents the migration of retinal pigment epithelium (RPE) cells., These data suggest that S6K1 may represent a molecular link between aging and Alzheimer disease., Our study indicated that Microcystin-LR exposure promoted HL7702 cell proliferation and the main mechanism was the activation of Akt/S6K1 cascade., Collectively, our findings suggested that both in vitro and in vivo differentiation of Th17 cells were positively regulated by p70(S6K1), Our results suggest that silencing of AT1R inhibits EMT induced by HG in HK-2 cells via inactivation of mTOR/p70S6K signaling pathway., This study report that protein levels of the p70 S6 kinase was increased in Progressive Supranuclear Palsy and Corticobasal Degeneration brains.,
SP_COMMENT catalytic activity:ATP + a protein = ADP + a phosphoprotein., enzyme regulation:Activation by serine/threonine phosphorylation and protein kinase C, inactivated by type 2A phosphatase., function:Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens., similarity:Belongs to the protein kinase superfamily., similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily., similarity:Contains 1 AGC-kinase C-terminal domain., similarity:Contains 1 protein kinase domain., subunit:Interacts with PPP1R9A/neurabin-1., tissue specificity:Widely expressed.,
ribosomal protein S6 kinase B2(RPS6KB2) ribosomal protein S6 kinase B2(RPS6KB2) Related Genes Homo sapiens
CHROMOSOME 11,
CYTOBAND 11q13.1,
ENSEMBL_GENE_ID ENSG00000175634,
GENERIF_SUMMARY p70 S6 kinase regulates neutrophilic differentiation in HL-60 cells, regulation of nucleocytoplasmic shuttling of S6KbetaII by protein kinase C-mediated phosphorylation, downstream effectors of PI3K, including PKB and p70 S6 kinase, in part mediate cell adhesion, spreading, and microspike formation induced by galectin-8, the PI3K/p70 S6K/c-Myc cascade plays an important role in neutrophilic proliferation in HL-60 cells., These data suggest that activated p70 S6 kinase could mediate an up-regulation of tau translation., p70 ribosomal protein S6 kinase activity was induced by K-Ras in a phosphatidylinositol 3-kinase and mTOR-dependent manner., IFNgamma-activated p70 S6 kinase phosphorylates the 40S S6 ribosomal protein on serines 235/236, to regulate IFNgamma-dependent mRNA translation., S6K2 is active throughout the cell cycle with higher activity in G2 and M phases., heterogeneous ribonucleoprotein F is involved in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway, Dysregulation of S6 kinases contributes to the pathogenesis of human diseases., S6K1 and S6K2 gene amplification was associated with a worse prognosis., Data show that genetic variation in RPS6KA1, RPS6KA2, and PRS6KB2 were associated with risk of developing colon cancer while only genetic variation in RPS6KA2 was associated with altering risk of rectal cancer., Study shows that the two homologues of S6K have distinct effects on Akt activation and cell survivalin breast cancer., S6K2 expression dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis, The p85 S6K1 promotes H2O2-induced cell death via a rapamycin-insensitive mechanism., S6K2 amplification was frequently observed in gastric cancer and was related to a poor prognosis, The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer., discovered that ERBB4 and S6K2 were the direct targets of miR-193a-3p and that PIK3R3 and mTOR were the direct targets of miR-193a-5p in non-small-cell lung cancer, Degradation of Tiam1 by casein kinase 1 and the SCFbetaTrCP ubiquitin ligase controls the duration of mTOR-S6K signaling.,
SP_COMMENT catalytic activity:ATP + a protein = ADP + a phosphoprotein., function:Phosphorylates specifically ribosomal protein S6., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the protein kinase superfamily., similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily., similarity:Contains 1 AGC-kinase C-terminal domain., similarity:Contains 1 protein kinase domain.,