Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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cyclin D1(CCND1) cyclin D1(CCND1) Related Genes Homo sapiens
CHROMOSOME 11,
CYTOBAND 11q13,
ENSEMBL_GENE_ID ENSG00000110092,
GENERIF_SUMMARY expression is related to apoptosis in thymus, TGFbeta and PTHrP control chondrocyte proliferation by activating cyclin D1 expression, The ability of p21(Cip1) to inhibit cyclin D1 nuclear export correlates with its ability to bind to Thr-286-phosphorylated cyclin D1 and thereby prevents cyclin D1.CRM1 association, Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1., Immunohistochemistry of cyclin D1 and beta-catenin, and mutational analysis of exon 3 of beta-catenin gene in parathyroid adenomas, TSG101 expression in gynecological tumors, Lower expression of p16 protein and overexpression of Cyclin D1 protein may be considered as prognostic biomarkers to skin carcinogenesis., Cyclin D1 play important roles in esophageal carcinogenesis., This study was conducted to explore the association between the polymorphism and the susceptibility to and disease status of TCC of the bladder in 222 cases and 317 native Japanese controls, Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4, cyclin D1 may be a target gene for prolactin in normal lobuloalveolar development, as well as in the development and/or progression of mammary cancer., analysis of expression improves differentiation of mantle cells from other lymphoma cells, Cyclopentenone causes cell cycle arrest and represses cyclin D1 promoter activity in MCF-7 breast cancer cells., A/G polymorphism of CCND1 was associated with the susceptibility to NPC, expression affected by estrogen receptors alpha and beta, Activation of cyclin D1 and D2 promoters by human T-cell leukemia virus type I tax protein is associated with IL-2-independent growth of T cells, The expression of MIB-1 and prognosis in cyclin D1(CyD1)+ and CyD1- mantle cell lymphoma (MCL)were studied and compared to B-CLL/SLL. The CyD1- group (nodal MCL and CLL/SLL) had a longer median survival time than the CyD1+ group (nodal MCL and MLP)., Overexpression of cyclin D1 is found to be significantly correlated with increased chromosomal instability in patients with breast cancer., The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation (RASSF1A), VHL-mediated hypoxia regulation of cyclin D1 in renal carcinoma cells., Cyclin D1 is a candidate oncogene in cutaneous melanoma., Overexpression of Icat induces G(2) arrest and cell death in tumor cell mutants for adenomatous polyposis coli, beta-catenin, or Axin., cyclin D1 is a novel ligand-independent co-repressor, Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma., The cyclin D1 high and cyclin E high subgroups of breast cancer, Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease., regulates cell cycle, Cyclin D1 expression in peripheral blood of 7 mantle-cell lymphoma pts was 1305.4 times higher than in 24 chronic B-cell lymphocytic leukemia pts., Data suggest that one mechanism by which INI1/hSNF5 exerts its tumor suppressor function is by mediating the cell cycle arrest due to the direct recruitment of HDAC activity to the cyclin D1 promoter, causing its repression and G(0)-G(1) arrest., overexpression of cyclin D1 sensitizes MCF7 cells to treatment with taxol, These data suggest that PKCdelta attenuates cyclin D1 promoter activity via the regulation of three distinct cis-acting regulatory elements., The CCND1 gene was rarely amplified in ILC in spite of showing overexpression of the protein in 41% of tumors. Hence, unlike IDC, increase in gene dosage did not account for the protein excess., upregulation of cyclin D1 and Fra-1 in human colorectal adenocarcinomas is driven by abnormally expressed beta-catenin, Strong cyclin D1 mRNA overexpression was detected in mantle cell lymphomas, hairy cell leukemias,and multiple myelomas. Intermediate transcript levels were found in some multiple myelomas and hairy cell leukemias., Amplifications of c-myc and CCND1 are associated with detrusor-muscle-invasive transitional cell carcinoma, inhibition of GSK3beta activity appears to trigger nuclear accumulation of cyclin D1 and cell cycle progression, early use of oral contraceptives may be associated with subset of mammary tumors that overexpress cyclin D1, Marked intratumoral heterogeneity of c-myc and this but not of c-erbB2 amplification in breast cancer, These results indicate that estrogen-induced cyclin D(1) transcription can occur in HepG2 cells independently of the transcriptional activity of estrogen receptor., Oct-1 potentiates CREB-dependent cyclin D1 transcriptional activity by a phospho-CREB and CREB binding protein-independent mechanism, Beta-catenin mutations correlate with over expression of C-myc and cyclin D1 Genes in bladder cancer, gene expression induced by galectin-3, CDK-independent transactivation of the estrogen receptor by cyclin D1 is, by itself, not sufficient to cause estradiol-independent growth of breast cancer cells. A vast overexpression of G1/S cyclins D1 A & E is able to do so by capturing CDK inhibitors., AA genotype of cyclin d1 polymorphism is associated with increased risk of prostate cancer, cyclin D1 expression initiates an apoptotic signal inhibited by different levels of cellular Bcl-2 at two points, Mantle cell lymphomagenesis results not only from direct consequences of inappropriate cyclin D1 expression but also from the ability of overexpressed cyclin D1 to buffer physiologic changes in p27 levels, rendering p27 ineffective as a growth inhibitor., PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth, Clonal aberrations of CCND1 together with high mRNA expression suggest a role for deregulated CCND1 activity in neuroblastoma tumorigenesis., The cyclin D1 A allele was associated with a diminished modulation of normal physiologic and treatment-induced decreased expression of cyclin D1., cyclin D1 has a role in regulating mitogenic signaling with IKKalpha, retinoblastoma protein has cyclin D1-inducing activity that is abolished by adenovirus E1A and that involves multiple pocket sequences that are independently involved in cyclin D1 activation, increases of cyclin D1, cyclin-dependent kinase 4, cyclin E, cyclin A, and Wee1 play an important role in the development of hepatocellular carcinoma from cirrhosis, gastrin appears to exert its mitogenic effects on gastric adenocarcinoma, at least in part, through changes in cyclin D1 expression., Comparative study in the expression of p53, EGFR, TGF-alpha, and cyclin D1 in verrucous carcinoma, verrucous hyperplasia, and squamous cell carcinoma of head and neck region., Cyclin G1 is frequently overexpressed in uterine leiomyoma in a p53-independent manner and that this abnormality could be attributed to the severe proliferation of human uterine leiomyomas., cyclin D1 (G870A) polymorphism is associated with susceptibility to esophageal and gastric cardiac carcinoma, Cells overexpressing cdk4 or cyclin D1 exhibited nuclear features characteristic of apoptosis., These results indicate that the altered expression of beta-catenin, but not cyclin D1, in hepatocellular carcinoma may play an important role in tumor progression by stimulating tumor cell proliferation., This study demonstrates that the CCND1 genotype may confer different risks for buccal squamous cell carcinoma (BSCC) and non-BSCC., The activation of Stat 3 and the dysregulation of this protein are mutually exclusive events in multiple myeloma., Cyclin d1 overexpression sensitizes breast cancer cells to fenretinide, Loss of von Hippel-Lindau protein causes cell density dependent deregulation of this protein through HIF., Cyclin D1 splice variants have differential effects on localization, RB phosphorylation, and cellular transformation, LPA may directly increase the level of cyclin D1 in ovarian cancer cells, increasing their proliferation., overexpression inhibits TNF-induced growth arrest, Presence is associated with high nuclear grade, large tumor size, and poor prognosis for glioma patients., ccnd1 polymorphism is associated with early lung cancer and contributes to susceptibility to lung cancer, cyclin D1 transcription is repressed by p53 through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1, Deregulation of cyclin D1 is associated with early stages of plasma cell dyscrasia, Cyclin D1 could be indirectly induced by ErbB signalling through p21. ER-mediated upregulation of cyclin D1 seems to be a possible mechanism of maintaining cell proliferation in DCIS in case of EGFR- and HER-2/neu-negativity., COX-2 or VEGF, but not cyclin D1 may play roles in breast cancer with poor prognosis, Data may suggest a possible role of the overexpression of cyclin D1 in the tumorigenesis of uveal malignant melanoma., Results describe how patterns of gene expression in human tumors have been deconvoluted to reveal a mechanism of action for the cyclin D1 oncogene., The data are consistent with an oncogenesis model in which a lack of PTEN fuels the cell cycle by increasing the nuclear availability of cyclin D1 through the Akt/PKB pathway., The cyclin D1 gene is overexpressed in human breast cancers and is required for oncogene-induced tumorigenesis, Up-Regulation of cyclin D1 and p21(Waf1/Cip1) is associated with differentiation of human myeloid leukemia cell lines, Study revealed a higher prevalence of both aberrant beta-catenin expression and cyclin D1 overexpression in papillary thyroid cancers around the Semipalatinsk nuclear test site than sporadic cases., Localized to suprabasal cells of telogen bulge and anagen outer root sheath(ORS). May mediate proliferation of stem cells in bulge to more differentiated transient amplifying cells in the suprabasal ORS., our data indicate that mutations of CCND1, which probably render the protein insensitive to degradation, represent a previously unreported mechanism of cyclin D1 overexpression in human tumors in vivo, the Cyclin D1/E2F1 pathway may be involved in apoptotic death of bone marrow cells in myelodysplastic syndromes, cyclin D1 expression is regulated by Pak1 in mammary glands and tumors, cyclin D1, besides growth pattern, is a prognostic marker for local recurrence in DCIS, transcriptional regulation of the key cell cycle regulator cyclin D1 and roles of both STAT5 and Oct-1 in this process, stabilized by HSV-1 ICP0 through degradation of cdc34, significant difference in their biochemical properties between CDK4/cyclin D1 and CDK2/cyclin A affecting regulation of cellular RB function, These data provide strong evidence that the CCND1 870A allele may be associated with colorectal cancer, and particularly with forms of the disease that result in severe morbidity and mortality., CCND1 G870A polymorphism has been reported as a genetic risk factor for some tumour types, it does not appear to be linked to the risk of breast and colorectal cancers., The beta-catenin-cyclin D1 pathway might be involved in the growth of endometrial carcinomas., In cervical cancers cyclin D3 may compensate for low levels of cyclin D1, whereas in corpus cancers both isoforms may contribute to the neoplastic phenotype., The CCND1 A870G polymorphism may increase risk for colorectal neoplasms., Moderate amplification of the CCND1 gene in Paget's disease of breast, cyclin D1 binding to wild type Cdk4 is stimulated by Cdc37, Cyclin D1 expression was evatuated in cell cycle responses to DNA mismatch repair-deficient cells upon methylation and UV-C damage., cyclin D1/Cdk4 complexes are regulated by calcium/calmodulin-dependent protein kinase I, There was no correlation between human papillomavirus status and cyclin D1 overexpression in human oropharyngeal squamous cell carcinoma., cyclin D1 is inhibited by PPARgamma2 activation in hepatocytes via CREB-dependent and beta-catenin-independent pathways, cyclin D1 accumulation in G(1) phase is regulated by calcineurin, expression of Egr-1, c-fos and cyclin D1 varies in esophageal precancerous lesions and cancer tissues, suggesting an involvement of these genes in the development of esophageal carcinoma., cyclin D1 has a role in tumorigenesis through interaction with C/EBPbeta, The expression patterns of cyclin D1, cyclin E, p21/waf1 and p27/kip1 in inflammatory bowel disease (IBD) may indicate their contribution in epithelial cell turnover and their possible implication in IBD-related dysplasia-carcinoma., results indicate an effect of gene dosage as an alternative mechanism of cyclin D1 deregulation in MM, overexpression may be involved in the formation of the giant cells and the pathogenesis of central giant cell granuloma, The authors found a correlation between CCND1 genotype and the age of onset of hepatoblastoma., Fluorescent in situ hybridization (FISH) and molecular analyses demonstrated involvement of the BCL1/CCND1 locus in a three-way translocation, Up-regulation of cyclin D1 is observed early in tumor formation, implying a possible role in tumor initiation., Presence in bone marrow cells indicated diagnosis of multiple myeloma., results suggest a model where RNA polymerase II bound at IgH regulatory sequences can activate the cyclin D1 promoter by either long-range polymerase transfer or tracking, cyclin D1-positive tumors tend to have perineural invasion more frequently.lymph vessel invasion is another factor related to cyclin D1 reactivity of the cells., The CCND1 variant A allele may recessively increase the risk of carcinoma in situ incidence in patients with superficial bladder cancer., Data show that CCND1 promoter activation by estrogens in human breast cancer cells is mediated by recruitment of a c-Jun/c-Fos/estrogen receptor alpha/progesterone receptor complex to the tetradecanoyl phorbol acetate-responsive element of the gene., Cyclin D1, p53, and p21Waf1/Cip1 have roles in progression of serous epithelial ovarian cancer, Data suggest that cyclin D1-Cdk2 complexes mediate some of the transforming effects of cyclin D1 and demonstrate that the cyclin D1-Cdk2 fusion protein is a useful model to investigate the biological functions of cyclin D1-Cdk2 complexes., Review of Cyclin D1 overexpression in squamous cell head and neck neoplasms resulting from abnormalities in chromosome 11q13., Synthesis is regulated by combined activity of ErbB2 and FGFR-4 that involves S6K1-mediated translation., regulation by SNIP1, Tumor growth inhibition might be due to apoptosis caused by reduced cyclin D1 expression as revealed by immunohistochemical analysis of tumor samples., Expression levels of CCND1 predict the cellular effects of mTOR inhibitors in ovarian carcinoma., C-terminal sequences direct cyclin D1-CRM1 binding, cyclin D1 binding to the androgen receptor NH2-terminal domain inhibits activation function 2 association, estrogen receptor mediates cyclin D1 expression and growth of tamoxifen-resistant tumors., CCND1 gains are early events in ovarian tumorogenesis., CCND1 alternate transcripts encode proteins with differing functions, overexpression of FAK promoted exit from G(1) in glioblastoma cells, enhanced expression of cyclins D1 and E while reducing expression of p27(Kip1) and p21(Waf1), and enhanced the kinase activity of the cyclin D1-cyclin-dependent kinase-4 (cdk4) complex, In colorectal cancer, the CCND1 copy number increase was neither associated with the tumor phenotype (stage and grade) nor with the tumor localization (colon, rectum or sigmoid colon)., Cyclin D1 central domain could be exploited to develop novel prostate cancer therapeutics., Cyclin D1 protein is upregulated in epithelioid sarcoma, suggesting a role in the pathogenesis of epithelioid sarcoma and appears to be regulated by translational and/or post-translational mechanisms., Endogenously released IGF-I leads to constitutive cyclin D1 expression in human neuroendocrine tumour cells., expression level of cyclin D1 RNA in bone marrow cells is predictive of the phase evolution in Chronic myeloid leukemia, Cyclin D1 may play a role in the early stage of gallbladder carcinoma., experiments suggest that both catalytic and non-catalytic functions of cyclin D1 can collaborate to inactivate pRb-mediated cell cycle exit, Cyclin D1 may be a potential target for molecular intervention in patients with oropharyngeal squamous cell cancer., We expressed cyclin D1 in the beta-cells of mice and islet hyperplasia developed in a time-dependent manner., activation in breast cancer cells is mediated by mayven, An associative interaction between XPD protein and CCND1 genetic polymorphisms, tobacco exposure, and cancer risk., Cyclin D1, D2, or D3 expression appears to be increased and/or dysregulated in virtually all MM tumors despite their low proliferative capacity, marked expression in high-grade tumors supports its role in proliferative activity, data indicate that altered expression of beta-catenin may play an important role in oral cancer progression through increased proliferation and invasiveness under epidermal growth factor receptor (EGFR) activation but not mutation or cyclin D1 expression, cyclin D1 overexpression is associated with non-small cell lung cancer, Bcl-1 staining was similar in all benign keratoses., AA genotype does not affect breast cancer risk., Amplification of Bcl-1 is associated with the development of uterine cervical carcinoma, To explore the potential prognostic value of cyclin D1 in invasive breast cancer, CCND1 polymorphism is associated with an increased risk of endometrial cancer., TAF1-dependent histone acetylation facilitates transcription factor binding to the Sp1 sites, thereby activating cyclin D1 transcription and ultimately G(1)-to-S-phase progression, exposure of cells to cadmium chloride results in cytotoxicity and cell death due to enhanced ubiquitination and consequent proteolysis of eIF4E protein, which in turn diminishes cellular levels of critical genes such as cyclin D1, Identification of mantle cell lymphoma with low cyclin D1 3'UTR is important because it seems to be associated with shorter overall survival., PKC-mediated exclusion of LIMK2 from the nucleus might be a mechanism to relieve suppression of cyclin D1 expression by LIMK2, cyclin D1 was localized in cell nuclei, levels of cyclin D1a and D1b alternative transcripts in mantle cell lymphoma may depend more on sample origin than on CCND1 polymorphism, cyclin D1 plays an important role in cellular proliferation and differentiation through regulation of p300., Atypical teratoid/rhabdoid tumor can be misdiagnosed as a variety of tumors, including ependymoma that potentially harbors LOH 22q. Our data indicate that cyclin D1 is a target of hSNF5/INI1in primary tumors., Increased cyclin D1 expression seen when earlier and later stage esophageal carcinomas stages compared, Cyclin D1 expression was significantly associated with tumour size and lymph node metastases in thyroid papillary microcarcinoma., cases of cyclin D1-negative mantle cell lymphoma (MCL) do exist and are part of the spectrum of MCL, an activating mutation of the beta-catenin gene affected regulation of the cyclin D1 gene, resulting in the generation of intrathoracic sporadic desmoid tumor, the Wnt signaling pathway plays an important role in carcinogenesis in intrahepatic cholangiocarcinomas through overexpression of its target genes, particularly cyclin D1, STAT5b may mediate the transcriptional activation of cyclin D1 after hypoxic stimulation., cyclin D1 nuclear localization has a role in cancer [review], SMAR1 regulates cyclin D1 by modification of chromatin through the SIN3/histone deacetylase 1 complex, The binding of STAT5 to the cyclin D1 promotor might up regulate cyclin D1 expression in oral squamous cell carcinoma., expression of cyclin D1 and c-Myc in epithelial ovarian cancer reaffirms the notion that they are crucial components in the pathway of tumorigenesis, p38 kinase activation is linked temporally with cyclin D1 expression after PH and appears to exert cell cycle control in the adult liver., integrin-dependent signal transduction events regulate the expression of cyclin D1 during G1 phase [review], Cyclin D1 expression may be a useful biomarker for assessing the risk of developing esophageal cancer., Hypermethylation of cyclin d2 is asspciated with prostate tumorigenesis, data support the hypothesis that the CCND1 A870G polymorphism may increase the risk of colorectal cancer in our Indian population, level of cyclin D1 negatively correlates with the proliferation properties of leukemic cells, TIMP-1-mediates cell-cycle arrest via cyclin D1 downregulation & p27KIP1 upregulation., These studies indicate that the altered AR regulatory capacity of cyclin D1b contributes to its association with increased prostate cancer risk and provide evidence of cyclin D1b-mediated transcriptional regulation., an association with alcohol consumption and the CCND1 gene or protein levels, in both esophageal and gastric cancers, This study demonstrates for the 1st time the involvement of MAPK-cyclin D1-p21(cip)machinery during cell growth inhibition and apoptosis of human vascular smooth muscle cells induced by cysthationine gamma-lyase overexpression., we identified ZONAB-responsive elements in cyclin D1 promoter, cyclin D1 expression is regulated by ZONAB, Cyclin D1 overexpression alters the proliferation and differentiation behavior of HaCaT skin keratinocytes in organotypic co-cultures., Our study suggests that the effect of cyclin D1 gene polymorphism on colorectal cancer risk is only observed in males and AA/AG genotype of cyclin D1 gene is associated with a higher risk of colorectal cancer, expression is repressed by SUMO modification of Sam68, the subtype 2 receptor-mediated antiproliferative effect of SRIH on TT cell proliferation may be exerted through a decrease in cyclin D1 and cdk4 levels, Cyclin D1 expression was not significantly different in normal cervix and in cervical cancer., These findings suggest heterogeneous abnormalities of CCND and RB in cutaneous T-cell lymphomas, in which dysregulated CCND and RB1 may lead to impaired cell cycle control., Differences in oncoprotein expression between endometriotic and adenomyotic tissues provide further evidence that the pathogenesis of endometriosis is different from that of adenomyosis., glucocorticoid receptor (GR) represses cyclin D1 via Tcf-beta-catenin, ionizing radiation is able to enhance cyclin D1 transcription induced by B[a]PDE, and NFAT3 is involved in the regulation of cyclin D1 transcription by B[a]PDE or B[a]PDE plus ionizing radiation, Mantle cell lymphoma should be very sensitive to targeted therapy aimed at functional inhibition of the cyclin D1/CDK4 complex., Results indicate that individuals carrying the CCND1 GG genotype have increased risk for the development of nasopharyngeal carcinoma., ERK1/2, JNK1/2 and p38 mapk pathways are all required for B[a]P-induced G1/S transition, Cyclin D1 promotes cellular motility through inhibiting ROCK signaling and repressing the metastasis suppressor TSP-1., Cav-1-deficient mammary acini displayed increased ERalpha levels and enhanced sensitivity toward estrogen-stimulated growth, with specific up-regulation of cyclin D1, Cyclin D1 is often mutated in esophageal cancer. The mutations disrupt phosphorylation at Thr-286, causing its nuclear accumulation. An acidic residue in the C-terminus is needed for recognition & phosphorylation by glycogen synthase kinase-3 beta., Cyclin D1 expression was higher in benzo(a)pyrene treated embryo lung fibroblasts than in controls., cyclin D1 expression is deregulated in idiopathic pulmonary fibrosis through a RhoA dependent mechanism that influences lung fibroblast proliferation, Study evaluated associations odds ratios and 95% confidence intervals in polymorphisms of seven candidate genes in 1,172 non-Hodgkin lymphoma (NHL) cases and 982 population-based controls, the cyclin D1 splice variant G870A (rs603965) increased NHL risk., When the combinations of the variables were assessed in two separate multivariate models, the combined variables p21/Ki-67 or p21/cyclin D1 expression were independent predictors for overall survival., CCND1 amplification is uncommon and appears to be late event in the development of ethmoid sinus adenocarcinoma., Pin1 expression is correlated with cyclinD1 expression and may have a role in esophageal squamous cell carcinoma, association between this CCND1 genotype and colorectal cancer risk in the Singapore Chinese Health Study., telomerase reverse transcriptase has a novel role in the modulation of cyclin D1 expression, novel signaling pathway links BRCA1-IRIS to cellular proliferation through c-Jun/AP1 nuclear pathway; finally, this culminates in the increased expression of the cyclin D1 gene, High levels of cyclin D1 expression is associated with salivary adenoid cystic carcinoma, Cyclin D1 overexpression is associated with endometrial carcinoma, Cyclin D1 or cyclin D3 are differentially used in the distinct mitogenic stimulations by growth factors or TSH., Expression of p27Kip1 in melanoma is regulated via cyclin D1 control of Cks1/Skp2-mediated proteolysis., HBx and NF-kappaB2/BCL3 mediated-cyclin D1 up-regulation might play an important role in the HBx-mediated HCC development and progression, The suppression of cyclin D1 levels during S phase is regulated by cell cycle position rather than signaling activity., Curcumin treatment inhibited cyclin D1 mRNA expression in K562 chronic leukaemia cells., DACH1 repressed cyclin D1 through a novel mechanism via a c-Jun DNA-binding partner, requiring the DACH1 alpha-helical DS domain which recruits corepressors to the local chromatin., After adjustment for age, sex, and smoking status, the AG genotype was associated with an increased risk for overall lung cancer, cyclin D1 may have a role in marginal zone lymphoma of mediastinum [case report], Alternatively spliced cyclin D1 mRNA isoforms a and b are expressed in mantle cell lymphoma (MCL) and multiple myeloma (MM). Cyclin D1b proteins are present in MCL, rarely in MM., subcellular localization is modulated by GSK-3beta and DYRK1B by phosphorylation of Thr(288), Cyclin D1 expression was not significantly different among 20% of esophageal dysplasia, 53% of esophageal squamous cell carcinoma and 20% of normal mucosa., PTEN may down-regulate the expression of PIP3, and then down-regulate the expression of cyclin D1, which leads to the suppression of cell growth., cyclin D1 overexpression is not a consequence of, but rather a pivotal element in the process of malignant transformation in the lung and other tissues. [REVIEW], Cyclin D1 is expressed in several kinds of brain cells following brain contusion, especially in glial cells., SCF(FBX4-alphaB crystallin) is an E3 ubiquitin ligase that promotes ubiquitin-dependent degradation of Thr286-phosphorylated cyclin D1., Alterations in adenomatous polyposis coli/beta-catenin pathway and cyclin D1 dysregulation may contribute to pathogenesis of pleuropulmonary desmoid tumors and solitary fibrous tumors., cyclin D1 may have a central role in mediating invasion and metastasis of cancer cells by controlling Rho/ROCK signaling and matrix deposition of TSP-1 [review], XRCC1-01, XRCC3-01, and CCND1-01 may be predictive of survival outcome in patients with metastatic breast cancer treated with DNA-damaging chemotherapy, Expression of membranous beta-catenin in salivary adenoid cystic carcinoma was down-regulated in most of the patients with lymph node metastasis., findings suggest that CDK4 cooperation with CCND1 may be involved in the progression of laryngeal tumors, p53 and Ki-67 were expressed with increasing frequency, and bcl-2, p21, and mdm-2 with decreasing frequency in thyroid carcinoma progression. p27 and cyclin D1 were expressed in <15% of cases, with a trend toward decreasing expression., By comparing the expression of p53, cyclin D1, p16, hTERT, and TSP-1 in spontaneously regressing keratoacanthoma and squamous cell carcinoma, the changes in the expression of these proteins to specific stages of skin carcinogenesis, is defined., eIF4E, along with VEGF and cyclin D1, has a role in translational regulation of proteins related to angiogenesis and growth, cyclin D1 has a role in progression of germ cell tumors, FBXW8 plays an essential role in cancer cell proliferation through proteolysis of cyclin D1. It may present new opportunities to develop therapies targeting destruction of cyclin D1 or its regulator E3 ligase selectively., the p38 MAPK/NF-kappaB/cyclin D1 signaling pathway might participate in the oncogenesis of extramammary Paget's disease, All grade II/III meningiomas showed increased expression of cyclin D1 and high proliferative activity, suggesting the combined expression of cyclin D1 and proliferation may define subgroups of meningiomas with a more aggressive biological behavior., deregulated expression of BRCA1-IRIS is likely to reduce dependence on normal physiological growth stimuli, Data suggest that trisomy 11 does not appear to directly cause CCND1 gene overexpression., genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that may have a role in progression of mantle cell lymphoma, These findings uncover specific residues conferring ubiquitination of cyclin D1 and provide a mechanistic basis for proteasomal degradation of cyclin D1., There was a highly significant positive association between p27(KIP-1) and estrogen receptor/progesterone receptor (ER/PR) status and with p27(KIP-1) and cyclin D1 expression. A trend between cyclin A and PR status was also identified., Cyclin D1/cdk4-mediated phosphorylation of BRCA1 inhibits the ability of BRCA1 to be recruited to particular promoters in vivo., CYCLIN D1 may be a target gene for leptin mediated growth stimulation of breast cancer cells and molecular mechanisms involve activated Stat3, The expression level of cyclin D1 and CDK4 protein increased in human embryonic lung fibroblasts treated with quartz., Interaction of MUC1 with CTNNB modulates cyclin D1 in H. pylori-induced stomach neoplasms., BCAR3 induces anti-estrogen resistance and augments transcription of the cyclin D1 promoter., GSK3beta may induce G(1) cell cycle arrest in a cyclin D1-dependent fashion and therefore possibly play a growth-inhibitory role in A549 cells., PTEN/PI 3-kinase signaling and cyclin D1 control a novel pathway that regulates assembly of the SCF(SKP2) complex., findings suggested that the G870A polymorphism of cyclin D1 may contribute to susceptibility to gastric cancer in Korean men, cyclin D1 expression in human tumoral parathyroid cells is regulated by calcium sensing receptor activation, Amplification of CCND1 is associated with recurrence and tamoxifen resistance in postmenopausal breast cancer, The function of cyclin D1b in cell cycle regulation was investigated, by generating B-cell lines displaying conditional expression of isoform b., a frameshift mutation (G base deletion) at nucleotide 82 of codon 28 in exon 4 of the cyclin D1 gene in a case of glioblastoma multiform (WHO Grade IV) sample., Our results indicate that the down-regulation of CCND1 is an essential step for DBC2's growth suppression of cancer cells., Taken together, our data suggest that Apr3 should play an important role in ATRA signal pathway., There are significant differences between Ki-67 indices and CCND1 expression among melanocytic lesions., Overexpression of cyclin D1 is associated with head and neck squamous cell carcinomas, a new role for YY1 as both an inducer of p53 instability in smooth muscle cells, and an indirect repressor of p21WAF1/Cip1 transcription, p21WAF1/Cip1-cdk4-cyclin D1 assembly and intimal thickening., There appears to be an influence of CCND1 870AA genotypes on esophageal cancer phenotype, particularly with regard to tumor location, which supports the theory of prevalence of site-specific genetic alterations, a significant proportion of pancreatic ductal adenocarcinomas is characterized by simultaneous protein alterations regarding p16 & cyclin D1 genes; this mechanism of genetic deregulation in cell cycle potentially explains in part the aggressive phenotype, This study provides a molecular basis to support the correlation of IL-8 expression with that of cyclin D1 in human prostate cancer and suggests a mechanism by which this chemokine promotes cell proliferation., Suberoylanilide hydroxamic acid caused a rapid decrease of cyclin D1 in mantle cell lymphoma by blocking the translation of cyclin D1 by inhibiting the phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR/eIF4E-BP pathway, probably by PI3K inhibition, Cyclin Dl over expression was evident among all cases of mantle cell lymphoma and few cases of large B-cell lymphoma, RbAp48-mediated transformation of HPV16 is probably because of the regulation by RbAp48 of tumor suppressors retinoblastoma and p53, apoptosis-related enzymes caspase-3 and caspase-8, E6, E7, cyclin D1 (CCND1), and c-MYC., that an O(2)(*-) signaling pathway regulates NAC-induced G(1) arrest by decreasing cyclin D1 protein levels and increasing MnSOD activity, There is co-expression of Cyclin D1 and BP1 in breast cancer. BP1 gene may promote the genesis of breast cancer through regulating the expression of Cyclin D1., Predominance of the Delta3'UTR mRNA was associated with higher cyclin D1 levels in cases with t(11;14), but did not correlate with the proliferation rate, suggesting a different role of this isoform in MM., The expression of cyclin D1 in hypopharyngeal squamous cell carcinoma was significantly higher than that in normal epithelium., strong correlation between CCND1 amplification and its protein expression in breast cancer, Levels of cyclin D1 gene expression were significantly higher in malignant thyroid tumours (papillary thyroid carcinoma, medullary thyroid carcinoma) compared to macroscopically unchanged thyroid tissue, follicular adenoma and/or nodular goitre groups., Ki-67 antibody and cyclin D1 overexpression seem to parallel each other, supporting the concept that cyclin D1 serves as a cell cycle activator in squamous cell carcinoma of the penis., mahanine can reverse an epigenetically silenced gene, RASSF1A in prostate cancer cells by inhibiting DNMT activity that in turn down-regulates a key cell cycle regulator, cyclin D1, in angiosarcoma, significant correlation was seen between phosphorylated-STAT3 and cyclin D1 but not between phosphorylated Akt and cyclin D1, Temporal control of cyclin D1 subcellular localization and proteolysis is critical for maintenance of homeostasis within the mammary epithelium of transgenic mice., The tumor-promoting activity of cyclin D1 may be tissue specific., p53 and Ki-67, but not bcl-2, cyclin D1 or HER-2 may have roles in the process of tumor genesis in non-small cell lung carcinoma, A431 cells expressing SIP1 along with exogenous cyclin D1 were highly invasive, Review of cyclin D1 and cyclin G and CDK acitivty and their roles in cancer pathogenesis, and their proteosomal degradation pathways as targets for cancer therapy, ZO-2 down-regulates cyclin D1 transcription by interacting with the c-Myc/E box element and by recruiting histone deacetylase 1, role for D-type cyclins in the excessive basal-cell proliferation and perturbed keratinocyte differentiation in the psoriatic epidermis, CCND1 polymorphism may be an early event in tumorigenesis, but it is not a reliable prognostic criterion., Cyclin D1 showed significantly higher median expression in thyroid cancer patients with netastatic papillary microcarcinoma compared to those without, indicating a correlation to tumour aggressiveness., This study aimed to explore, whether polymorphisms in BCL2, Cyclin D1, FAS, EGF and EGFR genes affect survival in a cohort of patients with squamous cell esophageal cancer treated with CT+RT with a view to identify the potential therapeutic targets., A high correlation between MUC1 and cyclin D1 implies MUC1 involvement in the Wnt cascade functioning in a large subset of human papillary thyroid carcinoma and papillary microcarcinoma, CCND1/GAPDH mRNA levels were significantly higher in lung cancer with EGFR mutation than in lung cancer without EGFR mutation, Alteration of CCND1 in Chinese patients with breast carcinoma and its correlation with Ki-67, pRb, and p53., roles for cyclin D1 in the development of PA and for cyclin D1 in the progression ofpleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma (CXPA) of parotid gland, The positive rate of Cyclin D1 was significantly higher in colorectal carcinoma, colorectal adenoma with malignancy, and colorectal adenoma than in normal colorectal mucosa., specific overexpression of Sox11 mRNA and nuclear protein in both cyclin D1-positive and - negative MCL may be useful for the diagnosis of MCL as a complement to cyclin D1 and also suggests a functional role for Sox11 in MCL., p53 is an indispensable component of cellular signaling system which is regulated by caveolin-1 expression, involving Akt activation and increase in cyclin D1, thereby promoting proliferation of breast cancer cells., that Rac1 is an essential player for mediating the induction of cyclin D1 and p21(Cip1) by HRG in breast cancer cells, Report a potential association of variants in the CCND1 and CDH1 genes with familial colorectal cancer using a unique study design with phenotypic extremes., Nuclear accumulation of Ccnd1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication., HSPB8 is a candidate CDK-independent cyclin D1 target that can mediate its effects, high cyclin expression may contribute to deregulation of the cell cycle in bone and soft tissue tumors, There was a positive correlation between TRAF2 and cyclin D1 expressions and the expression NF-kappaBp65 in the epithelial cells and lymphocytes in oral lichen planus., polymorphic variant of Aurora A does not appear to be associated with variation in colorectal cancer risk in HNPCC, whereas there is a more complex relationship between the Cyclin D1 polymorphism and disease risk in HNPCC, CCND1 G870A polymorphism makes a significant contribution to breast cancer with the preponderance of breast cancer in young women, Tissue expression of cyclin D1 or E1 seems not to add independent prognostic value to standard features in patients with nonmuscle -invasive urothelial cell carcinoma of the bladder., cyclin D1 reactivity is a considerably better marker of replicative senescence than senescence-associated beta-galactosidase activity., CCND1 polymorphisms stand-in as cis-acting regulatory elements modulating its expression and cyclin D1 genotype and phenotype could provide valuable additional information regarding prognosis of oral cancer patients., PKR and PKR-like endoplasmic reticulum kinase induce the proteasome-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2alpha phosphorylation, investigate the status of Her2, EGFR and cyclin D1 in 95 primary breast carcinomas, The Wnt pathway target gene cyclin D1 was found to be up-regulated specifically in the nonfunctioning pituitary tumors compared with controls at both mRNA and protein level, supportive of activation of the Wnt-beta-catenin pathway, MIF and cyclin D1 might be related to the growth and metastasis of hepatocellular carcinoma., alternatively spliced cyclin D1 modulates p27KIP1 binding and cell migration, The A allele and AA genotype of CCND1 G870A polymorphism have a significant association with an increased risk of the uterine leiomyoma in obese Korean women., Rac signaling to cyclin D1 is a crucial pro-proliferative effect of E-cadherin-mediated cell-cell adhesion, The CCND1 G870A polymorphism is not associated with the risk of CRC in the German population., The results demonstrate that PI-3K/Akt-mediated cyclin D1 expression is at least one key event implicated in the arsenite human skin carcinogenic effect., metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level, polymorphic alleles of HER2 and CCND1 may not play an important role as genetic markers for breast cancer risk, but presence of Val allele may be useful for tumor prognosis., These studies suggest the endogenous cyclin D1 promoter BRG-1 binding site functions as a molecular scaffold in the context of local chromatin upon which coactivators and corepressors are recruited to regulate cyclin D1., Cyclin D1 may mediate cell proliferation by different mechanisms in estrogen receptor (ER) positive and negative breast cancer., present study did not demonstrate a significant association between CCND1 genotype and oral squamous cell carcinoma, Expression of cyclin D1 is accelerated independently of beta-catenin in ameloblastomas., Only FIGO stage, cyclin D1, p27 (Kip1) and Ki-67 are independent prognostic factors that might help in predicting outcome of cervical cancer patients., Analysis of the pattern of expression of these biomolecules showed increased p16-positive phenotypes and decreased cyclin D1- and pRB-positive phenotype among the invasive tumors compared to low-grade CIN lesions, Cyclin D1 expression analysis in familial breast cancers may discriminate BRCAX from BRCA2-linked cases., tumor cell incubation with pioglitazone results in increased levels of p53 and p27 and decreased levels of cyclin D1, up-regulation of cyclin D1 by inflammatory factor-1 (AIF-1) pathway, A certain number of cyclin D1+ and CD5- diffuse large B-cell lymphomas exist that have structural aberrations at the CCND1 locus, including the t(11;14)., Cyclin D1 expression is an independent poor prognostic factor in women with early-stage, hormone receptor-positive breast cancer who received adjuvant tamoxifen-based therapy., The CCND1 A870G polymorphism had consistent associations with survival outcomes in head and neck neoplasms., The results indicate that the waiting time for onset of oncogenic virus-associated neoplasia in patients homozygous (GG) for CCND1 genotypes (52 years) was 12 years earlier in comparison with patients carrying AG or AA genotypes (60 years)., a reliable marker of gene aberration in plasma cell myeloma, Report overexpression of cyclin D1, D3, and p21 in renal carcinomas with Xp11.2 TFE3-gene fusion., Nerve growth factor induced the cyclin D1 promoter via Sp1, nuclear factor-kappaB, and cAMP-response element/activated transcription factor sites., DnaJB6 is necessary for translocation of Slfn1 into the nucleus, where Slfn1 down-regulates cyclin D1, induces cell-cycle arrest and programmes a quiescent state of T-cells, Cyclin D1 as a very useful proliferative marker in meningiomas., Cyclin E and cyclin D1 expression distinguishes non-BRCA1/2 tumors from both sporadic and BRCA1- and BRCA2-associated tumors and may reflect different predisposition and pathogenesis in these groups., gene copy numbers of CCND1 in breast cancers, 11q23 deletion along with relatively strong CCND1 expression was common in uremic hyperparathyroidism, Thus, an acidic environment triggers cytoplasmic localization and proteasomal degradation of cyclin D1., miR-34a reduces both mRNA and protein levels of cyclin D1 (CCND1) and cyclin-dependent kinase 6 (CDK6)., EWS-FLI1 directly stimulates cyclin D1 gene transcription., Genomic aberrations of Cyclin D1 in neuroblastoma indicate that dysregulation of the G(1) entry checkpoint is an important cell cycle aberration in this pediatric tumor., Id1 may contribute to early breast cancer by promoting excessive proliferation through cyclin D1., Data demonstrate that RNA interference of genes encoding cyclin D1 and cyclin D2 (CCND1 and CCND2, respectively) inhibits proliferation and is progressively cytotoxic in human myeloma cells., Cyclin D1 is induced in HaCaT+ by BARF1 and is overexpressed in EBV-associated gastric cancer indicating an interaction of viral BARF1 and cyclin D1., AP-1 activity and cyclin D1/E2F-1 expression in human embryo lung fibroblasts increased significantly after benzo(a)pyrene treatment., SOX2 and beta-catenin act in synergy in the transcription regulation of CCND1 in breast cancer cells, GPR30-mediated inhibition of urothelial cell proliferation is the result of decreased cyclin D1 by down-regulation of activation protein-1 signaling., ADAM17 mediates the EGFR/AKT/cyclin D1 pathway and cell cycle progression to the S phase induced by UVA radiation, miR-16-1 regulates CCND1 mRNA expression; role of miR-16-1 in the regulation of CCND1 in MCL, Loss of p16/Rb protein expression and overexpression of cyclin D1/CDK4 were observed in 49%/40% and 37%/37% of gastric carcinomas, respectively.Cyclin D1 and CDK4 overexpession was inversely associated with lymph node metastasis and depth of invasion., Estrogen and progesterone lower cyclin B1 AND D1 expression, block cell cycle in G2/M, and trigger apoptosis in human adrenal carcinoma cell cultures., A significant elevation in expression of CCND1 in oral squamous cell carcinoma cells was seen in carbon and neon-irradiated cells., These findings suggest that CCND1 (G870A) polymorphism may be associated with increased risk of squamous cell carcinoma of the uterine cervix in north Indian women., hnRNP A1 has a role in mediating rapamycin-induced alterations of cyclin D1 and c-myc IRES activity in an Akt-dependent manner and provide the first direct link between Akt and the regulation of IRES activity, Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer., cell cycle exit is preceded by p27-dependent inhibition of cyclin A-Cdk1/2, cyclin D1 downregulation and reduced pre-mitotic pRb pocket protein phosphorylation, CCND1870 GG genotype is associated with an increased risk for non-cardiac gastric cancer in patients in a high-risk area of China., we here propose that reactive oxygen species-mediated cyclin D1 degradation contributes to tumor growth retardation in hypoxic environments, Overexpression of cyclin D1 is associated with cholangiocarcinoma., cyclin D1 gene targeted cell lines lost the translocated chromosome (t(11;14)) and the nonrearranged cyclin D1 locus reverted from CpG hypomethylated to hypermethylated, cyclin D1b protein is aberrantly regulated and could contribute to therapeutic failure in the context of ER-positive breast cancer, Results describe the effects of estradiol on cyclin D1, PS2, and c-fos gene expression by measuring levels of RNA polymerase II on DNA templates, levels of nascent transcripts associated with RNA polymerase II, and levels of RNAs., beta-TrCP-dependent degradation takes part in controlling cyclin D1 turnover when cancer cells undergo glucose starvation, which endows physiological relevance to this novel mechanism., Overexpression may reflect early genetic events during the progression of Barrett esophagus-associated carcinogenesis., FGFR1-IIIb and FGFR1-IIIc are coexpressed, and the FGFR1-III isoforms are differentially regulated by growth factors and cyclin D1., Alterations of transcriptional regulators in disease may lead to splicing alterations., These studies identify a novel cyclin D1/miR-17/20 regulatory feedback loop through which cyclin D1 induces miR-17-5p/miR-20a., cytosolic cyclin D1 is able to regulate apoptosis by interaction with Bax in LDIR-induced adaptive resistance., These results demonstrate that ERKs and JNKs are responsible for the decrease of cyclin D1 and CDK4 expression levels in human embryonic lung fibroblasts induced by silica., The transcriptional activation of miR-302 and the translational repression of its targets, such as cyclin D1, may provide a link between Oct4/Sox2 and cell cycle regulation in pluripotent cells., The present data support a role for p27 in the assembly of D-type cyclin-Cdk complexes and indicate that both cyclin D1-Cdk4-p27 assembly and kinase activation are regulated by p27 phosphorylation., Results show that VRK1 activates CREB and regulates cell cycle progression in the DNA replication period by inducing cyclin D1 (CCND1) expression., Expression of cyclin D1 splice variants is differentially associated with outcome in non-small cell lung cancer patients., two mechanistically distinct phases of Rac-dependent cyclin D1 expression and emphasize that the acquisition of Rac/ERK co-dependence is required for the mid-G1 phase induction of cyclin D1 associated with S phase entry., Cyclin D1 and UBCH10 amplicons in anaplastic thyroid carcinoma., Activated STAT3 may take effect on promoting transcription of its downstream target gene CyclinD1., Inhibition of PI3-K/Akt induces a 40% decrease of cyclin D1 half-life as a result of accumulation of the dephosphorylated/active form of GSK-3beta within the nucleus, where it can phosphorylate cyclin D1 on Thr286 thereby promoting its nuclear export., Overexpression of Cyclin D1 is associated with lymph node metastases in laryngeal squamous cell carcinoma., The p16INK4a/cyclin D1/pRB pathway was altered in gastrointestinal tract endocrine tumors., Study shows a novel mechanism regulating Cyclin D1 expression and offers new insight into the role of SNIP1 and associated proteins as regulators of proliferation and cancer., We detected a cyclin D1 overexpression exclusively in bone marrows infiltrated with Mantle Cell Lymphoma (MCL), including minimal residual infiltration., Wild type RASSF1A expression could induce G1 phase arrest in QGY-7703 cells, which is accompanied by a down-regulation of Cyclin D1 protein expression through a post-transcriptional mechanism., CCND1 G870A polymorphism is associated with breast cancer., results suggest that the cyclin D1 870 G>A polymorphism is possibly involved in the development of endometrial cancer, GG genotype of CCND1 is associated with oral premalignant lesions., The chimeric mRNA is a bicistronic transcript of post transcriptional origin that independently translates the Cyclin D1 and Trop-2 proteins in cancer cells., Cyclin D1 and CDK4 were active genes and could positively regulate the cell cycle alterations induced by benzo(a)pyrene., Polymorphisms and expression of CCND1 might modify the level of DNA damage in vinyl chloride exposed workers., NDRG2 modulates intracellular signals to control cell cycle through the regulation of cyclin D1 expression via phosphorylation pathway and down-regulation of AP-1, univariate analysis showed overexpression of cyclin D1 & underexpression of p27 predicted lymph node metastases in papillary thyroid carcinomas; low risk group was cyclin D1 negative & p27 positive; high risk group was cyclin D1 positive & p27 negative, CK7, bax, CCND1, and HER2 represent marker proteins and frequently amplified genes in carcinomas of the ampulla of Vater., results show that human cyclin D1b has different biological functions than cyclin D1a and confirm its oncogenic properties, cyclin D1 has a role in cisplatin chemosensitivity in oral squamous cell carcinoma, TsA markedly down-regulated the expression of cyclin D1 and CDK4, up-regulated the expression of p21WAF1 and p53 and induced cell cycle arrest at the G1 phase in MCF10A-ras cells, Cyclin D1 activation is associated with Microsatellite instability and inversely with p21 loss in colorectal cancers., These results support the hypothesis that STAT3 and CREB play an important role in leptin signaling pathway that leads to the proliferation of Ishikawa cells, thus establishing a direct association between obesity and endometrial tumorogenesis., CCND1 amplification showed no relationship with tumour relapse., c-Fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear Cyclin D1., Ectopic cyclin D1 overexpression increases chemosensitivity but not cell proliferation in multiple myeloma., expression unchanged in Crohn's disease, ulcerative colitis, and amoebic colitis, Proliferation parameters of differentiating cells correlate with the activity and structure of cyclin A/E-CDK2 but not of cyclin D-CDK4/6-p27 complexes., the G/A870 polymorphism in the CCND1 locuw does not correlate with patient; however, total D1 expression seems to be associated with esophageal adenocarcinoma patient survival. survival, The findings suggest that a thalidomide-based regimen may overcome the poor prognosis associated with a cyclin D1-negative or fibroblast growth factor receptor 3-positive phenotype., These data indicate that communication between ATM and cyclin D1 may be required for maintenance of genomic integrity achieved by rapid arrest of the cell-cycle, and that disruption of this crosstalk may increase susceptibility to cancer., UBE1L-ISG15 preferentially inhibits cyclin D1 in lung cancer, ERKs and JNKs, but not p38, are responsible for the decrease of cyclin D1 and CDK4 protein expression level in human embryonic lung fibroblasts induced by quartz., Over-expression of the Tp53, CCND1, and C-myc genes appears to play a role in development of human cancer by regulating the expression of mRNA., The switch from Mnt-Max to Myc-Max during bile duct ligation (cholestasis) and in hepatocytes treated with lithocholic acid is responsible for the induction in p53 and cyclin D1 expression and contributes to apoptosis., Notch-1 may be mediated through regulating the expression of cell cycle regulatory proteins cyclin D1, CDK2 and p21 and the activity of Akt signaling, These results showed that the expression of cyclin D1, p21 and p27, alone or in combination, are early events in gastric tumorigenesis and may serve as a candidate molecular marker for the early gastric carcinoma., Levels of cyclin D1 mRNA were specifically reduced and binding of RNA Polymerase II to the CYCD1 promoter was decreased in Mcm7-depleted cells., Homeobox gene CDX2 inhibits human pancreatic cancer cell proliferation by down-regulating cyclin D1 transcriptional activity., Out of 710 SNPs in 120 candidate genes, the most significant association was CCND1 SNP rs3212879 in estrogen receptor-negative breast cancer., JAK2V617F-positive essential thrombocythemia and multiple myeloma with IGH/CCND1 gene translocation coexist, but originate from separate clones, The PKCalpha-ERK1/2 cascade is involved in PMA induced up-regulation of cyclin D1 and P21(cip1) and proliferation in human airway smooth muscle cells., Cdk-6 overexpression, alone or in combination with cyclin D1, strikingly stimulates human beta-cell replication, both in vitro as well as in vivo, without inducing cell death or loss of function., These findings support CD1 genotype and protein expression as important risk markers for laryngeal cancer, Decreased expression of CCND1 is associated with Increased expression of HER2 in breast tumors., either p57Kip2 "apice" or p27Kip1 "apice" inhibitors bound to cyclin D1/cdk4 complex, thus, suggesting that they cooperated to inhibit the activity of cyclin D1/cdk4., Poly E inhibits growth of transformed aerodigestive epithelial cells by suppressing cyclin D1 expression through both transcriptional and posttranslational mechanisms, positive expression of retinoblastoma protein and cyclinD1 might be an early event in gastric carcinoma, Adrenomedullin promotes cell transit beyond cell cycle phases with a concomittant increase in cyclin D1 protein level. Adrenomedullin effects cell proliferation through up-regulation of cyclin D1., A meaningful correlation was not found between grades of cyclinD1 expression and basal cell carcinomas, Overproduction of cyclin D1 is dependent on activated mTORC1 signal in nasopharyngeal carcinoma, crystal structure of CDK4 in complex with cyclin D1 at a resolution of 2.3 A, Amplifications and deletions of G1/S-phase transition genes, CCND1 and MYC is associated with early breast cancers., Strengthened signals in imputation-based analysis at CCND1 SNPs rs602652, rs3212879, rs649392 and rs3212891 lend evidence to the role of cell cycle genes in ovarian cancer etiology., specific cyclin D1 isoforms are associated with discrete forms of breast cancer and high cyclin D1b protein levels hold prognostic potential., non-small-cell lung cancer patients with eIF4E(+)/cyclin D1(-) have poorer outcome, those with eIF4E(-)/cyclin D1(+) have a more favorable outcome, and those with eIF4E(+)/cyclin D1(+) have an intermediate outcome (P = .02), the overexpression of cyclin D1 found in colon cancer favours tumour dedifferentiation as one mechanism of tumour progression., APRIL-mediated signaling in follicular lymphoma B-cell growth results in phosphorylation of Rb and up-regulation of cyclin D1, cyclin D1 expression might play a role in giant cell formation instead of promoting cell proliferation during Giant cell tumor of bone tumorigenesis, Data show that FGFR1 and DDHD2 at 8p12 cooperated functionally with MYC, whereas CCND1 and ZNF703 cooperated with a dominant negative form of TP53., Cyclin D1 A870G polymorphism in Brazilian colorectal cancer patients., In AML cyclin D1 mRNA was overexpressed, and its expression level was significantly higher than that in benign blood disease group, but there was no statistical difference among the subtypes of AML., CCND1 rearrangement and cyclin D1 overexpression in renal oncocytomas, ectopic expression of FBXO31 acts through a proteasome-directed pathway to mediate the degradation of cyclin D1, an important regulator of progression from G1 to S phase, resulting in arrest in G1, Cyclin D1b variant promotes cell invasiveness independent of binding to CDK4 in bladder cancer cells., Results show that overexpression of CDK4, cyclin D1, and Rb proteins, and loss of expression of proteins p16, p27, and p19 were statistically significant in NPC tissues compared with non-cancerous NPE (P<0.05) by real-time RT-PCR and tissue microarray., Quercetin inhibits human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway., PGP 9.5 and cyclin D1 coexpression was closely associated with tumor aggressiveness and can be classified as a marker for predicting the outcome of resection-treated skin cancer patients., APC, E-cadherin, beta-catenin and cyclin D1 may play important roles in tumorigenesis of esophageal squamous cell carcinoma(ESCC)., analysis of Cyclin D1 expression in typical chronic lymphocytic leukemia [case report], Cyclins B1, D1, and E1 have distinct expressions in different breast cancer subtypes., found overexpression of cyclin D1 in 4 of 11 cases of extramedullary plasmacytoma, associated with poor prognosis, cyclin D1 has a role in resistance to antiestrogen arzoxifene, CCND1 G870A polymorphism could act as a risk factor for the development of cervical cancer., propose that NGX6 expression is lost in the process of human colorectal carcinogenesis. Its overexpression can inhibit expression of transcription factors AP-1 and Ets-1, and down-regulate transcriptional activity of the cyclin D1 promoter in human CRC, DACH1 inhibits breast cancer cellular proliferation via cyclin D1., overexpressed cyclin B1, veiling the effect of cyclin D1 or cyclin E, mediated nickel-caused M-phase blockage and cell growth inhibition, which may render pulmonary cells more sensitive to DNA damage and facilitates cancer initiation, microRNAs that can silence cyclin D1 (CCND1) include miR-503, miR-19a and miR-155, but only miR-503 suppresses the protein expression, Cyclin D1 overexpression is associated with longer survival in colon cancer., Data show that DADS induces G(2)/M arrest in colon cancer SW480 cells, probably through the downregulation of PCNA, p53 and cyclin B1 and upregulation of p21(WAF1)., Cyclin D1 mRNA expression does not result in the production of functional CD1 protein in anaplastic large cell lymphoma., The CCND1 870A allele is associated with nasopharyngeal carcinoma in Han population., Data indicate that cyclin E2-Cdk2 activation by estrogen occurs via E2F- and CHD8-mediated transcription of cyclin E2 downstream of cyclin D1, and does not require c-myc., over-expression of DIXDC1 might target p21 and cyclin D1 to promote colon cancer cell proliferation and tumorigenesis at least partially through activation of the PI3K/Akt pathway., Cyclin D1 interacts with both FOXO1 and FOXO3a and inhibits their transcriptional activity and anoikis-promoting function., Cyclin D1 polymorphisms are associated with cervical cancer., The MAPK kinase-1/2 inhibitor, U0126, fully restored cAMP down-regulation of CCND1 in endometrial stromal fibroblasts of women with vs. without endometriosis., An immunohistochemical and molecular study of the BCL2, MKI67, and CCND1 genes in Synovial sarcoma (SS) was performed. The high level of BCL2 mRNA correlated with a high level of CCND1 mRNA, but not with MKI67 mRNA level., Data show that sorafenib inhibited the raf/ MEK/ERK signal pathway, and downregulated cyclin D1 and Rb levels., XRCC1, CCND1 and GSTM1 polymorphisms have roles in oral leukoplakia after exposure to tobacco, co-amplification of CCND1 and EMSY identified a poor prognostic subset of ER-positive tamoxifen-treated patients, Loss of cyclin D1 in ovarian cancer cells treated with SHetA2 is sufficient to induce G(1) cell cycle arrest and this strategy is not impeded by the presence of cyclin E2., Results confirm the importance of alterations in CCND1 and CTTN with respect to areca-associated oral squamous cell carcinoma, and demonstrates that there is an early occurrence of amplification of these genes in the risk population., Cyclin D1 and pRb showed a progressive increase in expression from benign to malignant tumors but with relative decreases in the more advanced tumors (thick primaries and metastatic melanomas)., Immunoreactivity index of p21 and cyclin D1 is independent of the morphological pattern of human endometrium, patients' age and gynaecological history of patients., Data show that the knockdown of cyclin D1 is compensated by the upregulation of cyclin D2, a more powerful strategy would be to inhibit both cyclin D1 and cyclin D2., immunostaining of p16, cyclin D1, Ki-67, p53, and ProEx C was evaluated in 144 cervical tissue specimens encompassing normal or benign epithelial lesions, low- and high-grade squamous intraepithelial lesions and cervical carcinoma, cyclin D1b is specifically elevated in prostate tumorigenesis, Data show that the inhibition of cell proliferation with L.lac CF was associated with an increase in p53 and p21 expression, the reduction of cyclin D1 expression, and retinoblastoma protein phosphorylation., Overexpression of Notch1 in laryngeal carcinoma cell line was coupled with the downregulation of cyclin D1, IKKalpha, IKKbeta, RANK, Maspin, c-FLIP, Cip2 and cyclinD1 were found to show significant differences between hepatocellular tumor tissue and its corresponding adjacent tissue., Studies indicate that mTOR inhibition treatment strategy was owing to the characteristic overexpression of cyclin D1 regulated by mTOR signaling., It appears that the G870 polymorphism of CCND1 is not associated with the risk of GC in the Japanese population., The risk of breast cancer development and prognosis may be associated with genetic variation in the CCND1 genotype, which may be used as a biomarker for further studies., there was no significant difference in cyclin D1 expression between BRCA2 and BRCAX cancers, Amplification of both PPFIA1 and CCND1 were significantly associated with high-grade breast cancer phenotype but were unrelated to tumor stage or nodal stage, Fndings suggest that the selected polymorphisms of p21, CCND1, and caspase8 may not contribute to the risk of colorectal cancer., Data show that P53 can inhibit cyclin D1 promoter activity via an NF-kappaB site-dependent manner and its binding activity increased after heat shock., Data show that B[a]PDE increases cyclin D1 expression, and activate the PI3-kinase/Akt/MAPK- and p70s6k pathway in Beas-2B bronchial epithelial cells., sox11 may be involved in the upregulation of cyclin D1 in hairy cell leukemia, Chondrocytes in cartilage biopsies of ACH children were characterized by the presence of growth arrest mediated by STAT(signal transduction and transcription) activation and increased expression of p21(p21CIP1) and cyclin D1, Compared with the normal cerebellum, expression of cyclin D1 in medulloblastoma was significantly higher. Upregulation correlated with metastases, pathological type, necrosis, & differentiation level & direction., Study identified an overrepresentation of focal amplifications of known (FGFR3, CCND1, MYC, MDM2) and novel candidate genes (MYBL2, YWHAB and SDC4) in stage Ta bladder carcinoma., The cyclinD1 and IL-1RN polymorphisms were associated with survival in neoadjuvant-treated gastric cancer., these data highlight the regulatory role of the cyclin D1 3'UTR in the expression and phenotype of cyclin D1, Data suggest that the amplification of the cyclin D1 gene can predict the more aggressive natural course of proliferating haemangiomas and the limited outcome and higher incidence of complications after non-excision treatment modalities., Zinc protoporphyrin regulates cyclin D1 expression independent of heme oxygenase inhibition., we determined the significance of loss or downregulation of CD79a, overexpression of cyclinD1, and c-maf expression in bone marrow specimens with plasma cell myeloma, aberrant regulation of S100P in HCC might activate cyclin D1 and CDK expression and contribute to the mitogenic potential of tumor cells during Hepatocellular carcinoma carcinogenesis., among endometrial stromal tumors and related sarcomas, undifferentiated endometrial sarcomas featuring uniform nuclei were characterized by frequent coincident expression of beta-catenin and cyclin D1., beta-Catenin and Cyclin D1 increased in gliomas may be precipitate the tumorigenesis of glioma., Exposure of human cancer cell lines to caffeine and CGK733 was associated with a rapid decline in cyclin D1 protein levels, High CCND1 amplification is associated with estrogen receptor positive breast cancer., Cyclin D1 expression was increased by enhanced mRNA cap methylation., We show that JAG1 down-regulation reduces direct binding of Notch to the cyclin D1 promoter, Findings suggest that targeting USP2 is an effective approach to induce growth suppression in the cancer cells addicted to cyclin D1 expression., 59% of Paget's disease of the vulva cases examined overexpressed cyclin D1 compared with 8% of Paget's disease of the breast cases., Expression of cyclin D1 and P21WAF1 is related to drug-resistance of gastric cancers., The etiology of gastric cancer is involved in multiple genetic and epigenetic alterations, by molecular biological study, including oncogenes cell-cycle regulators (such as cyclin D1), Cyclin D1 is a bona fide target gene of NFATc1 and is sufficient in the mediation of injury-induced vascular wall remodeling, Data suggest that wogonin induced G1 phase arrest in HeLa cells by modulating several key G1 regulatory proteins, such as Cdk4 and cyclin D1, as well as up-regulation of a p53-mediated p21Cip1 expression., Data show that Cyclin D1, a major target of ERalpha, is transcriptionally up-regulated by IKKepsilon in a phospho-ERalpha-Ser-167-dependent manner., There was no significant association between breast cancer risk and the combined genetic polymorphisms of CCND1 and ESR1 in Korean women., the cyclin D1b represses breast cancer cell growth by antagonizing the action of cyclin D1a on ERalpha-mediated transcription, Fluorescence in situ hybridization was more sensitive than Southern blot at demonstrating low levels of gene amplification and, additionally, permitted assessment of the distribution of cyclin D1 gene among chromosomes., Our results identify Sam68 as the first splicing factor to affect CCND1 alternative splicing in prostate cancer cells, cyclin D1 can be included within an immunohistochemical panel to aid in the distinction between reactive cervical glandular lesions and adenocarcinoma in situ., data show that alphaB-crystallin is highly expressed in melanocytes contributing, in part, to cyclin D1 turnover, Data show that LLL12 inhibited STAT3 phosphorylation, induced apoptosis as indicated by the increases of cleaved caspase-3 and poly (ADP-ribose) polymerase, and also downregulated cyclin D1, Bcl-2, and survivin at both protein and messenger RNA levels., Tax binds the cyclin D1 promoter-proximal cyclic AMP response element (CRE) in the presence of phosphorylated CREB (pCREB) in vitro, and together the Tax-pCREB complex recruits the cellular co-activator p300 to the promoter., Increased protein expression of p16 and cyclin D1 in squamous cell carcinoma tissues., CCND3 is the primary driver of the cell cycle, in cooperation with CCND1 that integrates extracellular mitogenic signaling., Ep-CAM or cyclin D1 expression is a unfavorable prognostic factor in gallbladder carcinoma., GATA3 as a gene involved in transcriptional regulation of Cyclin D1., ZIP4 overexpression causes increased IL-6 transcription through CREB, which in turn activates STAT3 and leads to increased cyclin D1 expression, cyclin D1 expression was significantly correlated with lymphatic metastasis and neoplasm invasiveness in papillary thyroid carcinoma., Breast cancer cell motility is affected by disturbing cyclin D1 levels or cyclin D1-cdk4/6 kinase activity., There is no statistically significant association between the expression of cyclin D1 and overall survival or relapse of patients with laryngeal cancer., The water extract of the lettuce Lactuca sativa activated checkpoint kinase 2, induced the tumour suppressor p21, and downregulated the proto-oncogene cyclin D1 in HL-60 leukaemia cells and MCF-7 breast cancer cells, Rem2 mediates the fibroblastic growth factor 2 (FGF2) signaling pathway to maintain proliferation of hESCsby suppressing the transcriptional activity of p53 and cyclin D(1), High glucose stimulated mesenchymal stem cell proliferation through cyclin D1/E and TGF-beta(1) expression via Ca(2+)/PKC/MAPKs as well as PI3K/Akt/mTOR signal pathways., miR-193b represses cell proliferation and regulates CCND1 expression, data do not show an association between CCND1 A870G SNP and Crohn's disease-associated or ulcerative colitis-associated colorectal neoplasia, These results suggest that increased cyclin D1 expression, which occurs in liver regeneration and liver diseases, may contribute to the feminization seen in these settings., CCND1 G870A single nucleotide polymorphism is associated with an increased risk of hepatocellular carcinoma in our Turkish population, There was significant direct correlation between the expression of Pin1 and Cyclin D1 in laryngeal papilloma., Stat3 and Cyclin D1 were overexpressed in laryngeal neoplasm tissue, and they have a positive relationship., Hemin inhibits cyclin D1 and IGF-1 expression via STAT5b under hypoxia in ERalpha-negative MDA-MB 231 breast cancer cells, up regulation of EGFR, cyclin D1 and h TERT proteins correlates with advanced stage in squamous cell carcinoma of the larynx, Prediction of CCND1 amplification using plasma DNA is thought to be a promising prognostic biomarker in esophageal squamous cell carcinoma patients., These data link the SMRT corepressor directly with SRC family coactivators in positive regulation of ERalpha-dependent gene expression., Genetic polymorphism of CCND1 is associated with CpG island hypermethylation status in gastric cancer, especially in the advanced stage, but is independent of clinico-pathological features., Cyclin D1 might be involved in the process of human pulmonary artery smooth muscle cell proliferation and migration stimulated by cigarette smoke extract., Cyclin D1's participation in a feed-forward loop could contribute to increased breast cancer risks associated with estrogen and progesterone combinations., Increased expressions of PKCalpha and cyclin D1 might be involved in the pathogenesis of abnormal proliferation of pulmonary artery smooth muscle cells in smokers with normal lung function and smokers with mild to moderate COPD., Protein kinase C alpha promotes the proliferation of human airway smooth muscle cells sensitized with atopic asthmatic serum via up-regulation of cyclin D1 expression., CCND1 amplification was associated with breast cancer., our meta-analysis strongly suggested that the CCND1 G870A polymorphism is not associated with head and neck cancer risk, cyclin D1b participates into multiple myeloma pathogenesis via previously unrevealed actions., Alternative splicing of the CCND1 transcript is associated with prostate cancer progression., Data show that that cyclin D1 gene was amplified in 45.4% of ESCC patients., The G870A polymorphism in CCND1 may not contribute to the etiology of cervical cancer in Chinese populations., BRAF V600E mutations are associated with MSI-H status and cyclin D1 overexpression and characterize a subgroup of patients with poor prognosis., in HPV positive oropharyngeal cancer, cyclin D1 has a role in locoregional recurrence, event and death and pRb has a role in event and death, Hr and VDR interact via multiple protein-protein interfaces, catalyzing histone demethylation to effect chromatin remodeling and repress the transcription of VDR target genes that control the hair cycle., Rac1 knockdown by RNAi interference confirmed the specificity of NSC23766 and requirement for Rac1 in the regulation of cyclin D1, survivin, and XIAP in breast cancer cells., Positive correlation between high heterogeneity, centrosome abnormalities and CCND1 amplification was found in T1G3 bladder carcinomas., Treatment of HepG2 cells with HMBG1 increases expression of cyclin D1 and PCNA., Expression of Slug decreases cyclin D1 expression in human prostate cancer cells., Increased risk of urinary bladder cancer was associated with the combined variant CCND1 genotypes among men 65 years of age and smokers. The G870A polymorphism was significantly associated with risk of developing superficial urinary bladder cancer., Perioperative total parenteral nutrition has no significant impact on the expression of cyclin D1, recurrence or metastasis of colorectal cancer., Overexpression of CCND1 is associated with good response to bortezomib therapy in multiple myeloma., Abolishing the expression of cyclin D1, Cdk4 or Nek2 in MCF10A human mammary epithelial cells expressing H-Ras(G12V) abrogated Ras-induced centrosome amplification., SCCA, EGFR and cyclin D1 may prove to be useful tumor markers in oral squamous cell carcinoma., The gene expressions of cyclins D1 in Cushing's disease were significantly suppressed than those in non-functioning adenomas., clodronate has little influence on osteoblast proliferation and extracellular matrix production in terms of cyclin D1 gene expression, Expression of constitutively active mTOR conferred resistance to cryptotanshinone inhibition of cyclin D1 expression and Rb phosphorylation, as well as cell growth., Overexpressions of nuclear cyclin D1 is associated with non-small cell lung cancer., High cyclin D1 is associated with squamous cell carcinoma in non-small cell lung cancer., the CCND1 870A gene variant may be a genetic risk factor in the incidence of advanced cervical cancer, cyclin-D1 overexpression is associated with leiomyosarcoma., Findings suggest that genetic variants of A870G might be associated with distant metastasis and also gender in colorectal cancer., CDKN1B polymorphism appears to be a predictive factor for breast cancer and CCND1 polymorphism may be a prognostic biomarker. Larger study groups are needed to fully elucidate the role of CCND1 and CDKN1B polymorphisms in the development and prognosis., In HeLa cells, mir-200b directly reduced the expression of RND3 at the mRNA and protein levels, which thereby promoted expression of the downstream protein cyclin D1 and increased S-phase entry, In KRAS mutant tumors, PIK3CA mutation restores cyclin D1 expression and G(1)-S cell cycle progression so that they are no longer dependent on KRAS and MEK/ERK signaling., p53 Expression was statistically more common with less cyclin D1 expression in Chinese as compared with Australian women., The data suggest that URG4 may play an important role in the development of hepatocellular carcinoma by partially regulating the expression of cyclin D1., Celastrol inhibits the proliferation and induced the apoptosis of HL-60 cells which may be related with down-regulation of p-Act and cyclin D1 expressions., Data demonstrate that mantle cell lymphoma with t(11;14)(q13;q32) has the level of cyclin D1 increased by four orders of magnitude, while other B-cell lymphomas without t(11;14)(q13;q32) have the level of cyclin D1 significantly elevated above normal., COX-2 inhibitor can inhibit the expression of BCL-3 and cyclin D1 in a dose-dependent manner human colon cancer cell line SW480., cyclin D1 provides a transcriptional switch that allows the tumor suppressor activity of RUNX3 to be repressed in cancer cells., The protein expression levels of Wnt1, beta-catenin and Cyclin D1 were all positively correlated with the Karnofsky performance scale (KPS) score and World Health Organization (WHO) grades of patients with gliomas., Data indicate that cyclin D1 (CCND1) AA genotype demonstrated increased risk for developing prostate cancer (CaP)., show elevated La protein expression in cervical cancer tissue and its correlation with aberrant CCND1 protein levels in cervical tumor tissue lysates, Homocysteine-induced differential activation of Ras/ERK and PI3K/Akt/p70S6K signaling pathways and consequent expression of cyclins A and D1 are dependent on beta1 integrin., Cyclin D1 expression was associated with tumor stage and recurrence., Data show that proliferaton and nuclear expression of cyclin D1 and p-Rb coincide with the early phase of cyst growth, suggesting that there might be a therapeutic window in which cyclin-dependent kinase inhibitors are most effective in ARPKD., The results reveal that knock-down of the beta-catenin gene decreases expression and nuclear translocation of beta-catenin protein in colon cancer HT-29 cells and suppresses the expression of the beta-catenin-dependent genes cyclin D1 and c-myc., Increased PRMT5 activity mediates key events associated with cyclin D1-dependent neoplastic growth, including CUL4 repression, CDT1 overexpression, and DNA rereplication., Novel function of cyclin D1 illustrates the interplay between tumor proliferation and migration and may explain the attenuation of malignant behavior in breast cancers with high cyclin D1 levels., Cyclin D1 and cyclin D-dependent kinases enhance oral keratinocyte proliferation but do not block keratinocyte differentiation., SLUG inhibits the expression of UbcH5c directly through chromatin remodeling and thus, among other downstream effects, elevates the level of cyclin D1, The present results demonstrate that beta-catenin and p65subunit bind to the cyclin D1 promoter, but only beta-catenin is capable of activating transcription., RPA1 and RPA2 overexpression seems to be more important during early T-categories of bladder carcinogenesis, showing similar kinetics with cyclin D1, Phosphorylated Stat5 may play an important role in cyclin D1 overexpression and contribute to colonic adenocarcinoma progression., Case Report, Rare variants of CCND1 are risk factors for colorectal cancer, with considerably larger effects than common polymorphisms., overexpression of cyclin D1 were found in cells of solid-pseudopapillary tumors., Cyclin D1 expression is associated to facial outcome after vestibular schwannoma surgery. The prognostic value of cyclin D1 expression is independent of tumor size and facial nerve stimulation at the end of surgery., Findings support a role for the AKT-dependent regulation of AIP4/Itch activity in mediating the differential cyclin D1 and c-MYC transcriptional responses to rapamycin., Cyclin D-1 protein over-expression is not associated with gene amplification in benign and atypical apocrine lesions of the breast., The A allele of the CCND1 G870A polymorphism may confer additional breast cancer risk when it comes to homozygosity and Chinese populations., beta-catenin expressed in nuclei/cytoplasm increases cyclinD1 protein expression, which invokes pterygial cell proliferation., Results suggested that the Cyclin D1 A870G polymorphism is associated with an increased risk of SGTs in the Chinese population. The Cyclin D1 AA genotype not only increased the risk of PA, but also increased the expression of Cyclin D1 in these tumors., Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer, laryngeal cancer is characterized by high proliferative potential mediated by increase in cyclin D1 and H3 mRNAs expression., Two alternative splicing variants of cyclin D1 are identified, cyclin D1b and cyclin D1a, which are associated with cellular migration., Cyclin D1 is a selective modifier of androgen-dependent signaling and androgen receptor function., study identifies miR-378-TOB2-cyclin D1 as a functional module to mediate the cross talk between Myc and Ras signaling in cellular transformation, Cyclin D1 overexpression was observed in 47.7% of tumors in the young group and in 32.8% of controls. In the young group, protein overexpression correlated with diminished disease-free survival., There appears to be an influence of CCND1 G870A/G1772C genotypes on genetic susceptibility to esophageal squamous cell carcinoma, Cyclin D1 single nucleotide polymorphisms are associated with oral cancer., Cyclin D1 positive diffuse large B-cell lymphoma is a post-germinal center-type lymphoma without alterations in the CCND1 gene locus., ROC1 expression is negatively correlated with cyclin D1 expression, demonstrating its importance in the degradation of cyclin D1 in melanomas., This study is the first to demonstrate that K(+) channels such as hEag1 are directly involved in the IGF-1-induced up-regulation of cyclin D1 and E expression in MCF-7 cells., Cyclin D1 gene silence by lentivirus-mediated RNA interference can inhibit growth and promote apoptosis of laryngeal squamous cell carcinoma., Elevations in CYCLIN D1 mRNA expression in older persons may indicate that a compensatory expression of this transcript is occurring in an attempt to retain the muscle's proliferative potential., EMSY amplification does occur independently of CCND1 amplification in a minority of familial breast cancers, supporting its role as a possible breast cancer oncogene, the overexpression of cyclin D1 in rectosigmoid cancers may be more complicated than purely upregulation by beta-catenin, We show here, in an experimental model of cyclin D1 fusion protein transduction in mature B cells, that, cyclin D1 inhibits total mitochondrial activity, Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1., immunohistochemical analysis of MT1 and cyclin D1 in breast cancer specimens from 33 patients, CCND1 amplification is more likely to be associated with breast cancer tumour progression., Aurora-A overexpressing cells fail to overcome the restriction point at the G1/S transition due to diminished RB phosphorylation caused by reduced Cyclin D1 expression., The subcellular location of cyclin D1 expression in prostate cancer is linked to specific clinical courses, Data show that the expression of CCND1/CDKN2A correlated with RB1 status in xenograft tumors in vivo., c-Kit, p-ERK, and cyclin D1 might help to differentiate thin melanoma from melanocytic nevus, Study elucidates a model to regulate glioma cell cycle progression in which hUCBSC acts to control cyclin D1 induction and in concert its partner kinases, Cdk 4 and Cdk 6 by mediating cell cycle arrest at G(0)-G(1) phase., over-expression of human OVCA1 in ovarian cancer cells leads to down-regulation of cyclin D1, TERT expression highly correlated with cyclin D1 expression in laryngeal squamous carcinoma, Copy number changes at 11q13 and 8q34 harboring CCND1 and MYC, respectively, are highly associated with prognosis in melanoma skin cancer., The C allele of the CCND1 C1722G polymorphism may be a potential predictive and prognostic biomarker for advanced urothelial cancer., human antigen R knockdown reduces the growth and invasion of breast cancer cells in vitro and affects expression of cyclin D1 and MMP-9, The cyclin D1 870A allele is a low-penetrant risk factor for development of sporadic colorectal cancer., The immunoexpression of cyclin D1 was significantly increased in the HPV-positive group compared to the HPV-negative group., Higher expression of cyclin D1 in oral cancer appears to be closely linked to cell proliferation, differentiation and lymph node invasion., CGH array indicated that cases having cyclin D1 with increased copy number were significantly associated with elevated FBXO31 expression levels (P<0.05). FBXO31 could be a novel and robust prognostic marker for ESCC., Result suggests that the cyclin D1 870A allele is a low-penetrant risk factor for developing sporadic colorectal cancer, especially among Caucasians., High cyclin D1 is associated with thyroid papillary carcinoma., Apigenin increases CASP3 and CASP8 mRNA expression but decreases mTOR and CCND1 mRNA expression in HT29 cells., expression of LPP3 in human colon tumor (SW480) cells potentiated tumor growth via increased beta-catenin stability and CYCLIN-D1 synthesis, study indicates that CCND1 rs9344 polymorphisms confer host susceptibility to cervical cancer. A allele possesses a relative protective effect probably through the cyclin D1b's inhibition on HPV carcinogenesis, the CCND1 G870A polymorphism may be an ethnicity-dependent risk factor for digestive tract cancers, findings reveal an unexpected function of a core cell cycle protein in DNA repair, cyclin D1; targeting cyclin D1 may be beneficial also in retinoblastoma-negative cancers which are currently thought to be unaffected by cyclin D1 inhibition, Adrenal incidentaloma patients who also carry the polymorphic BCL1 variant exhibit smaller size adrenal nodules., Data show that combination of siRNA-mediated inhibition of the cyclin D1 and cyclin D2 along with chemotherapeutic agents could potentially be used to lower the effective doses of the chemotherapeutic agents and reduce drug-related toxicities., role of cyclin-D1 in deregulating apoptosis in mantle cell lymphoma cells, The expressions of CDK4 and Cyclin D1 increased along with progression of gallbladder mucosa hyperplasia and p16 decreased to the lowest level in gallbladder cancer., immunohistochemical expressions of cyclin D1, p16(INK4a) and Ki-67 were analyzed in a total of 127 cases showing multinucleated giant cells, in a cohort of patients with plasmablastic lymphoma of the oral cavity, an increased copy number of the CCND1 gene was seen in 41% of cases with true amplification of CCND1 in 15% of cases, CCND1 GG genotype was associated with a lower risk overall in urothelial (P = 0.008, OR = 0.44, 95% CI = 0.24-0.81) and bladder cancer patients (P = 0.008, OR = 0.34, 95% CI = 0.15-0.76) than those of the AA genotype., p16( INK4a) is also a modulator of transcription and apoptosis through controlling the expression of two major transcription regulators, AUF1 and E2F1, increased FHIT gene activity can promote apoptosis of cholangiocarcinoma and reduce the expression level of cyclin D1., reduced expression of the ATM and aberrant cyclin D1 expressions may contribute to the development and/or malignant progression of breast carcinomas, Apoptosis decreased in HL-60 cells with upregulated expression of CCND1 and hTERT., Survival in stage I-II radiotherapy treated head and neck cancer did not depend on ERCC2 A35931C or CCND1 G870A genotype., significant relationship between nucleostemin and cyclin D1 expression in ovarian neoplasms, Overexpression of cyclin D1 enhanced the proliferation and invasive potential of human glioblastoma cells, while reducing apoptosis., Findings reveal that an exogenous EGF stimulation may enhance HPV-related cervical cancer cell proliferation by activating EGFR and cyclin D1 that is independent of COX-2 levels., These results indicate that increased migration of MDA-MB-231 cells following cyclin D1 silencing can be mediated by Id1 and is linked to an increase in EMT markers., in ovarian carcinomas, findings show that patients with high positivity for p53, p16(INK4a) and Cyclin D1 had a poor prognosis and reduced overall survival, CCND1 rs9344 polymorphism together with smoking habit maybe a useful biomarker for lung cancer prediction., The 5-years survival rate was 26% for the group with strong nuclear expression of cyclin D1, and 80% for the group with moderate expression of the marker., CCND1 A870G may be useful in predicting clinical outcome in HER2-positive metastatic breast cancer patients treated with lapatinib plus capecitabine., an analysis of the combined expression of EZH2 and cyclin D1 can serve as a more powerful prognostic predictor for patients with HNSCC., CCND1 amplification is associated with a more aggressive phenotype within histological grade 2 tumours and luminal A subtype tumours., We didn't reveal any important correlations between clinicopathological findings and galectin-3 and cyclin D1 expression and in non small cell lung cancer. We didn't observed also prognostic value of cyclin D1 or galectin-3 expression., Data show that cyclin D3 is significantly upregulated in breast cancers and frequently exceeds the expression of Cyclin D1 in ErbB2-positive cases., The aim of the present study was to explore and correlate membrane and nuclear EGFR and cyclin-D1 protein expression with EGFR gene status in colorectal carcinomas, Gene Expression ratios of CCND1 protein may predict survival and prognosis in patient with oropharyngeal squamous cell carcinomas., The hypothesis that CCND1 expression determines response and clinical outcomes in locally advanced head and neck squamous cell carcinoma (HNSCC) patients treated with neoadjuvant chemotherapy, was tested., microRNA-365, down-regulated in colon cancer, inhibits cell cycle progression and promotes apoptosis of colon cancer cells by probably targeting Cyclin D1 and Bcl-2., Data show that CCND1 expression was an independent baseline predictor of survival in systemic light chain amyloidosis (AL)., study demonstrates concordant cyclin D1-related induction profiles of ultraviolet B radiation and arsenite using cDNA microarray analysis., The cyclin D1 expression is unlikely to be useful as a prognostic marker for NSCLC in clinical practice from current evidence. The conclusion should be confirmed by a large well-designed prospective study. [Review], Cyclin D1 expression was not correlated with survival in penile cancer., CCND1 amplification and co-alternation of CCND1(+) /pRb(-) /ppRb(+) may play a crucial role in the prognostic evaluation of patients with esophageal cancer; patients with CCND1(+) /pRb(-) /ppRb(+) have the worst prognosis in all the patients, expression of cyclin D1 in papillary thyroid cancer is linked to nodal metastases and that cyclin D1 levels are regulated by Wnt/beta-catenin signaling., Cyclin D1 is molecularly involved in strengthening tumoral proliferation mechanisms in young women and may be seen as a potential blocking molecular switch in corresponding tumors in old women., Resveratrol down-regulates the protein cyclin D1 and, in a concentration dependent manner, the phosphorylation levels of protein kinase B and glycogen synthase kinase-3beta in OVCAR-3 ovarian cancer cells., The high expression level of Stat3 and Cyclin D1 protein in laryngeal squamous cell carcinoma was correlated with the clinical stage, tumor differentiation and lymph node metastases., binding of ErbB3(80 KDa) on the promoter activates Cyclin D1 transcription and subsequent protein expression, leading to an increased cell proliferation., results indicate a role of quinone reductase 2 in the control of AKT/GSK-3beta/cyclin D1 and highlight the involvement of NQO2 in degradation of cyclin D1, as part of mechanism of chemoprevention by resveratrol, Increased STAT3 and decreased cyclin D1 protein levels may contribute to the recurrence of astrocytic tumours., Positive amplification of cyclin D1 was detected in 72% (36) of OSCCs., CCND1 G870A polymorphism modulated oncogenic cyclin D1b expression in glioma tissues and may be associated with an increased risk of gliomas in Chinese population, The regulatory role of CD1 on NF-kappaB activity, was investigated., cyclin D1 contributes to chromosomal instability and tumorigenesis by directly regulating a transcriptional program that governs chromosomal stability, Overexpression of cyclin D1 is associated with aggressive behavior in mantle cell lymphoma., MUC1-C oncoprotein contributes to TCF7L2 activation and thereby promotes cyclin D1 expression in breast cancer cells., CCND1 +870A>G polymorphisms and larger tumor size were associated with poor 5-year disease-free survival by the log rank test and multivariate Cox proportional hazards model analysis, CCND1 G870A polymorphism is associated with the increased risk of colorectal cancer, especially for sporadic colorectal cancer and in Caucasians, Cyclin D1 overexpression is associated with oral cavity squamous cell carcinoma., Silica could induce the high expression of cyclin D1 and CDK4 and the low expression of E2F-4, resulting in the cell cycle changes by AP-1/cyclin D1 pathway in human embryonic lung fibroblasts., Geranylgeranoic acid induced rapid downregulation of cyclin D1 in several human hepatoma cell lines, and that this may be a plausible mechanism involved in hepatoma chemoprevention., Rsf-1 is overexpressed in non-small cell lung cancers and contributes to malignant cell growth by cyclin D1 and ERK modulation., EpCAM enhances cell cycle progression via the classical cyclin-regulated pathway., results showed there were significant differences between nasopharyngeal carcinoma and control groups in the distribution of the genotypic and allelic is an obvious joint effect of CCND1 A870G genotype with smoking habit on nasopharyngeal carcinoma susceptibility, CCND1 is amplified and overexpressed in a substantial proportion of vulvar carcinomas and associated with the occurrence of locoregional lymph node metastases, especially in human papillomavirus-negative tumors., polymorphism at on chromosome 11q13.3 modulates the binding and function of hypoxia-inducible factor at a transcriptional enhancer of CCND1 specific for renal cancers, Overexpression of hyaluronan-binding protein 1 (HABP1/p32/gC1qR) in HepG2 cells leads to increased hyaluronan synthesis and cell proliferation by up-regulation of cyclin D1 in AKT-dependent pathway., Cyclin D1 homogenous staining regions correlate with poor prognosis in cutaneous melanoma., Slow progression into S-phase in gamma-tocopherol treated prostate cancer cells is marked by increased TG2 expression and decreased CyclinsE and D1., Activation of the STAT3/cyclin D1 signaling pathway may be attributed to the malignant transformation of NSCLC., Lin-28 homologue A (LIN28A) promotes cell cycle progression via regulation of cyclin-dependent kinase 2 (CDK2), cyclin D1 (CCND1), and cell division cycle 25 homolog A (CDC25A) expression in cancer., CCND1 amplification and low nuclear expression of cyclin D1 predicted poor clinical outcome in postmenopausal breast cancer patients treated with either anastrozole or tamoxifen., The PI3K/Akt, JNK, and ERK pathways were found to mediate MIC-1-induced cyclin D1 expression in HUVECs., There is a close relationship between cyclin-D1 expression and ovarian cancer cell activity. A positive correlation is found between lower expression of cyclin-D1 and the concentration of cisplatin., Meta-analyses of available data show a significant association between the CCND1 G870A polymorphism and lung cancer risk, and CCND1 G870A polymorphic variant A contributes to increased risk of lung cancer., The present study suggests that reduced expression of cyclin D2 in stage III NSCLC may be associated with poor RFS. And, cyclin D2 may have a distinct role from cyclin D1 in NSCLC., In conclusion, cyclin D1 shows heterogeneity in distribution and intensity in benign and malignant thyroid tumors, which disqualifies it as a primary diagnostic marker in these tumors, Expression of cyclin-D1 in bone marrow in subjects with multiple myeloma is correlated with survival of these patients; up-regulation of cyclin-D1 predicts shorter overall survival., intact EFGR and TIF2 complex was linked with cyclin D1 promoter activity in an LMP1-dependent manner, Cyclin D1 overexpression and CCDN1 amplification, loss of p16 expression and p16 deletion may be among the genetic alterations involved in the pathogenesis of nasopharyngeal carcinoma, CCND1 G870A polymorphism was significantly associated with overall colorectal cancer risk. Increased risk was observed only in subgroups of hospital-based studies, PCR-RFLP genotyping methods, sporadic colorectal cancer, and Caucasian ethnicity. Review., Cyclin D1 expression significantly increases with increase in differentiation., activation of SIRT1 inhibited the proliferation of pancreatic cancer -PAUF cells by down-regulation of cyclin-D1, a target molecule of beta-catenin., SOX11 is useful in differentiating cyclin D1-positive diffuse large B-cell lymphoma from mantle cell lymphoma, Automated image analysis of cyclin D1 protein expression in invasive lobular breast carcinoma provides independent prognostic information., The recognition of cyclin D1 expression in the proliferation center of a significant minority of chronic lymphocytic leukemia/can be a diagnostic aid and should not lead to the diagnosis of focal mantle cell lymphoma., expression of ATM and cyclin B1 may be useful markers to identify patients with poor prognosis who may benefit from close follow-up and aggressive therapy in pancreatic neuroendocrine tumors., analysis of phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7, Confirm that cyclin D1 plays an important role in the growth of pancreatic cancer cells and that tumor growth can be inhibited using a tetracycline-inducible cyclin D1 antisense expression system., Identified a significant epistasis effect BCL1 by CHRNA4 showing that carriers of the CC genotype at the BCL1 locus who were also homozygous for the T allele at the CHRNA4 locus had the highest depression scores., Case Report, Expression of cyclin D1 in pituitary tumors is related to cell proliferation, recurrence, and metastatic potential., Early mantle cell lymphoma infiltrates or minimal accumulations of cyclin D1-thornositive B cells occur in tissues from mantle cell lymphoma patients, sometimes antedating lymphoma diagnosis for several years., Slug regulates cyclin D1 expression by ubiquitin-proteasome pathway in PCa cells, Cyclin D1 G870A polymorphism is associated with breast cancer., Cyclin D1 was down-regulated, while p21 expression was up-regulated by EGCG in dose- and time-dependent manners., Cyclin D1 expression does not have prognostic role in lymph node negative colorectal cancer., Data show that the MEK-ERK pathway regulates cell cycle-related neuronal apoptosis (CRNA) by elevating the levels of cyclin D1, and the increase in cyclin D1 attenuates the activation of cyclin-dependent kinase 5 (cdk5) by its neuronal activator p35., Required for TLR-9-mediated cyclin D1 expression and subsequently cell proliferation., Overexpression of Cyclin D1 is associated with Breast Cancer., Cyclin D1 mRNA/protein expression levels were increased in ectopic tissue in peritoneal endometriosis., this study found that CARMA3 is overexpressed in colon cancers and contributes to malignant cell growth by facilitating cell cycle progression through NF-kappaB mediated upregulation of cyclin D1., Protein kinase N1 is a novel substrate of NFATc1-mediated cyclin D1-CDK6 activity and modulates vascular smooth muscle cell division and migration leading to inward blood vessel wall remodeling., A allele of CCND1 G870A polymorphism confers additional lung cancer., SUMO modification of Stra13 is required for repression of cyclin D1 expression and cellular growth arrest, RNA inhibition highlights cyclin D1 as a potential therapeutic target for mantle cell lymphoma., findings show transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region (3'-UTR); data demonstrate that CCND1 contributes to osteosarcoma cell proliferation, In patients with stage I-III colorectal cancer, co-existence of CCND1 and VEGF overexpression had significantly poorer disease-free survival rates (P = 0.004) and overall survival rates (P = 0.001)., miR-338-3p inhibits proliferation by regulating CyclinD1 and HBx down-regulates miR-338-3p in hepatocelullar carcinoma., CCND1 G870A gene polymorphism was compared in prolactinoma patients/control and invasive/noninvasive groups. CCND1 G870A gene polymorphism may be an important factor in the early stages of the tumor formation., We suggest that analysis of both GSK3b and cyclin D1 expressions can be considered as a marker of good prognosis in early breast cancer., When evaluating high-grade uterine sarcomas, cyclin D1 can be included in the immuno-histochemical panel as an indicator of YWHAE-FAM22endometrial stromal sarcoma., Low CCND1 expression is associated with the progression of cutaneous malignant melanoma., results suggest that CCND1 G870A polymorphism might be a low-penetrant risk factor for esophageal carcinoma, particularly among Asians, study to analyze TACSTD2 and Cyclin D1 expression at the mRNA and protein levels and to assess its prognostic significance in invasive ductal breast cancer (IDC); expressions of TACSTD2 and Cyclin D1 in IDC tissues were consistently higher than those in tumor-adjacent non-malignant tissues, HPV infection is strongly associated with the pathogenesis of BP, and HPV may be involved in the regulation of the expression of cell cycle related proteins, cyclin D1 and cyclin E, in the pathogenesis of Bowenoid papulosis., These findings suggest that CCND1 expression is possibly regulated by estrogens via ERbeta and that this signaling pathway may influence prostate cancer development., H2A.Z-dependent crosstalk between enhancer and promoter regulates cyclin D1 expression., Our analysis provides evidence that genotypes for the CCND1 A870G polymorphism may be associated with an increased risk of developing oral cancer in the Asian population., The CCND1 G/A polymorphism is associated with the early onset of head and neck cancer (HNC) and may contribute to HNC susceptibility in a Pakistani population., miR-122 target gene cyclin G1 has regulatory effects on hepatitis C virus replication., PAX2 protein induces expression of cyclin D1 through activating AP-1 protein and promotes proliferation of colon cancer cells., miR-31 and miR-130b may have an effect on tumorigenesis of cold and benign thyroid nodules by regulating proliferation and apoptosis and the cell cycle through cyclin D1., dysregulated expression of cyclin D1 in nasopharyngeal epithelial cells may contribute to nasopharyngeal carcinoma pathogenesis by enabling persistent infection of EBV, this study provided evidence that cyclin D1 overexpression may be a marker of prolonged survival in patient subgroups with aggressive phenotypes., the expression of cyclin D1, MCM7, TRIM29, and UBE2C was found to be significantly associated with progression to muscle-invasive bladder cancer., Data indicate that Overexpression or knockdown of miR-145 altered both the mRNA and protein levels of HIF-2alpha and its downstream genes, cyclin D1, matrix metalloproteinase 14 and vascular endothelial growth factor, in neuroblastoma cells., Kaiso represses the cell cycle gene cyclin D1 via sequence-specific and methyl-CpG-dependent mechanism., CCND1 G870A polymorphism is associated with breast cancer susceptibility., This comprehensive characterization of a large series of cyclin D1(-) mantle cell lymphoma patients indicates that these tumors are clinically and biologically similar to the conventional cyclin D1(+) MCL., Oleuropein down-regulates NF-kappa B and cyclin D1 but activates p21 in MCF-7., our data suggest that the ClC-3 chloride channel is an important target of cyclin D1. Cyclin D1 may regulate the functional activities of the chloride channel via CDK4 and CDK6, and/or the expression of the chloride channel., The expression of Cyclin D1 was not correlated with any clinicopathological parameters in hepatocellular carcinoma, leptin induces human NP cell cyclin D1 expression and proliferation via activation of JAK/STAT3, PI3K/Akt or MEK/ERK signaling, Results suggest that obesity may contribute to asthma and associated tissue remodeling by modifying the processes related to the CCND1 gene activity., Our findings suggest that p16(INK4A) overexpression is likely secondary to cyclin D1 gene upregulation or amplification in salivary gland tumors, Report cyclin D1 expression in breast papillomas and papillary carcinoma., it appears that cyclin D1, CDK4 and p16 function independently in human breast cancer., Cyclin D1 polymorphisms are associayted with prostate-specific antigen recurrence after radical prostatectomy., The AG and AA of cyclin D1 genotypes were found to be associated with an increased risk of CRC compared to the GG genotype, with an almost 2-fold increase in OR., miR-195 plays an important role to inhibit the proliferation of glioma cells, and present a novel mechanism for direct miRNA-mediated suppression of cyclin D1 and cyclin E1 in glioma, miR-9 suppresses the expression of cyclin D1 and Ets1 via the binding sites in their 3'-UTR, thus inhibiting the proliferation, invasion and metastasis of gastric cancer., The molecular mechanisms underlying cyclin D1 overexpression-induced DNA double-strand breaks during DNA replication in acquired radioresistant cells, is reported., Constitutive CCND1/CDK2 expression contributes to neoplastic mammary epithelial cell transformation., Study assesses the role ofCCND1 genetic variants in fl uencing the genetic susceptibility of non-small cell lung cancer., In localized laryngeal cancer, clinicopathological parameters and an interaction of high mTOR and CCND1 mRNA expression were found to be associated with poor patient outcome, Expression of CCND1 in cholesteatoma was significantly increased compared to normal external ear canal. In cholesteatoma, a significant positive association was observed between NF-kappaB and CCND1 expression., Cyclin D1 expression and CCND1 amplification seem to have a prognostic value for OSCC. Further studies of HNSCC should always consider subanatomic genetic differences, Single nucleotide polymorphisms in CCND1 gene is associated with multiple myeloma., Although CCND1gene amplification has been observed in central giant cell lesion of the jaws, no difference was observed between the clinical forms of this lesion., Cyclin D1 expression could be used as a biomarker in further validation studies to select cN2 patients that could benefit from induction therapy., Our results suggest that the post-transcriptional regulation of the CCND1 expression by BHD may be associated with microRNA(s) or RNA binding protein(s) that bind to the 3'UTR., Propolis extract significantly increased the mRNA level of cyclin D1 in the sigmoid colon mucosa, and the other biomarkers remained unchanged., Functional variants at the 11q13 risk locus for breast cancer lowers cyclin D1 expression through long-range enhancers., GCN5 has a role in potentiating growth of non-small cell lung cancer by promoting E2F1, cyclin D1, and cyclin E1 expression, This over-expressed miR-2909 was found to regulate CCND1 (Cyclin D1) gene expression., cyclin D1 overexpression correlates strongly with patient survival in oropharyngeal squamous cell carcinoma, but its relationship with human papillomavirus status is very tight, CCND1 rs9344 G>A may be a predictive and/or prognostic biomarker in stage II/III colon cancer patients, however, prospective trials are warranted to confirm our findings, Cyclin D1 immunohistochemical expression associates strongly with the approved favourable prognostic factors in primary breast carcinoma., Small interfering RNA silencing of cyclin D1 and BCL-2 expression in osteosarcoma cells enhances the toxicity of doxorubicin., SUMO modification of ATF3 influences CCND1/2 activity and cellular proliferation of prostate cancer PC3 and DU145 cells and explains at least in part how ATF3 functions to regulate cancer development., Report association of cyclin D genetic polymorphisms with acute lymphoblastic leukemia and breast cancer., Data indicate that estrogen induced the expression of c-Jun, Fra-1, c-Fos, cyclin D1 and cyclin E1 while tamoxifen (TMX) decreased the expression., Polymorphism in CCND1 gene is associated with breast cancer., overexpression of SOX11 has been demonstrated to be specific for MCL independent of CCND1 positivity, suggesting a diagnostic role of SOX11 expression in t(11;14)-negative MCLs, Results of a meta-analysis suggest that the CCND1 G870A polymorphism might be a low-penetrant risk factor for lung cancer, particularly among Asians and smokers., Show higher expression of cyclin D1 in parabasal layer of odontogenic keratocyst and the entire cystic epithelium of glandular odontogenic cysts compared to dentigerous cysts and radicular cysts., the CCND1 G870A polymorphism might not be a potential candidate for predicting esophageal cancer risk (Meta-Analysis), NRAS or KIT mutations and cyclin D1 amplification can be found in a proportion of primary melanomas of the sinonasal tract., CCND1 overexpression impacts the prognosis of ER-positive breast cancer patients, but not patients with unselected primary breast cancer or patients treated with neoadjuvant chemotherapy., Cyclin D1 overexpression is a potential prognostic marker of primary oropharyngeal squamous cell carcinoma., The correlation between CCND1, E2F3 and miR-449b showed that miR-449b could downregulate CCND1 and E2F3 expression. This, in turn, reduced the proliferative ability of colon cancer stem cells., In head and neck squamous cell carcinoma, a significant difference in local control rates was observed between patients with cyclin D1-positive and -negative margins., KAI1/CD82 and cyclinD1 may serve as markers for determination of invasiveness, metastasis and prognosis of laryngeal squamous cell carcinoma., Data indicate that XIAP E3 ligase mediates cyclin D1 transcription via PP2A-regulated c-Jun/AP-1 activation., Data suggest that endometrioid endometrial cancer tissue have decreased microRNA-503 levels compared to normal tissue; down-regulation of miR-503 relieves suppression of its target CCND1 which in turn accelerates cell cycle progression., Exogenous mutant cyclin D1 (T286I) accumulated in the nuclei., Data indicate that depletion of NFATc1, cyclin D1, CDK6, or CDK4 levels attenuated MCP1-induced Pak1 phosphorylation/activation and resulted in decreased aortic smooth muscle cells (HASMCs) F-actin stress fiber formation, migration, and proliferation., UBE2D3 participates in the process of radiosensitivity in human breast cancer cells by regulating TERT and cyclin D1., Thus, our findings highlight the cyclin D1/p21 signaling axis as a critical regulator of TGFb-mediated tumor growth initiation and local tumor cell invasion, both in vitro and in vivo., Our results identify for the first time the downstream targets of insulin, cyclin D1, and BAD, elucidate a new molecular mechanism of insulin in promoting cell proliferation and apoptosis, Co-amplification of these candidate genes or the CCND1 amplification along with either BRAF or NRAS mutations might be more important for prognosis than the presence of these alterations alone., The positive relation observed between tumor metastasis and cyclinD1 expression and p16 with nodal metastasis suggested that higher cyclin D1/p16 expression may act as a predictive biomarker for aggressive behavior of gallbladder malignancies., Results suggest that cyclin G1-induced liver tumor-initiating cells expansion contributes to the recurrence and chemoresistance of hepatoma, and may be a promising biomarker for individualized therapy of hepatocellular carcinoma patients., Post-transcriptional regulation of cyclins D1, D3 and G1 and proliferation of human cancer cells depend on IMP-3 nuclear localization., Localization of CycD1 in the cytoplasm during skin differentiation could be related to the changes in detachment ability of keratinocytes committed to differentiation., Cyclin D1 and CDK4/6 have alternate roles in regulation of migration and cancer stem-like cell activity., hyperelevated cyclin D1, a marker of hyperactivation of senescent cells, did not necessarily determine other markers of senescence. inhibition of MEK was sufficient to eliminate cyclin D1, regardless of MTOR., Findings suggest that aluminum concentration does not affect genomic stability of ERBB2, C-MYC, and CCND1 genes in breast tissues., Cyclin D1 mediates the convergence of ERalpha and growth factor signaling at a common cis-element of growth factor genes., Studies suggest that Cyclin D1 (CCND1) G870A polymorphism may be a risk factor for lung cancer., CCND1 amplification status and CyclinD1 expression are independent risk factors in metastasizing bladder cancer. High nuclear CyclinD1 expression in lymph node metastases predicts favorable response to chemotherapy., G870A polymorphism most likely contributes to increased susceptibility to bladder cancer in the overall population, hospital-based case-control studies, and Asians., cyclin D1 has a role in promoting cell cycle progression by enhancing NDR1/2 kinase activity independent of Cdk4, Thus, the results show that CCND1 gene polymorphism may be a predictor for detecting patients with poor survival who having metastatic disease., Exposure of cells to excessive H2O2 induced ubiquitin-dependent proteasomal degradation of cyclin D1., Neither cyclin D1 nor beta-catenin was expressed in a statistically significant manner, concluding that the development of MCCs is independent of beta-catenin and cyclin D1 expression and these proteins are not suitable as prognostic markers., WT1 is an oncogene and promotes NSCLC cell proliferation by up-regulating Cyclin D1 and p-pRb expression, This study reveals a pivotal role of combined Dmp1 loss and cyclin D1 overexpression in breast cancer., Cyclin D1 was up-regulated in endometrial lesions but lacks specificity to differentiated non-neoplastic and neoplastic endometrial tissues., As2O3 induced dose-dependent and time-dependent increases in apoptosis accompanied by cyclin D1 suppression., Cyclin D1b expression plays a role in a part of human colorectal carcinogenesis., miR-21 controlled the expression of cyclin D1 through NFkappaB-dependent transcription in renal cancer cells., The genetic polymorphism of CCND1 A870G might be a potential biomarker for predicting acute AEs in postoperative stage II and III rectal cancer patients treated with adjuvant concurrent chemoradiotherapy of capecitabine and oxaliplatin., Cyclin D1 gene G870A variants are associated with primary brain tumors., High CCND1 expression is associated with bladder cancer., Treatment with metformin upregulated the expression of p21CIP and p27KIP, but downregulated cyclin D1 levels, both in vitro and in vivo, SDF1 exerts a quiescent effect on resident c-kit(+) CSPCs by decreasing CK1alpha levels, increasing GSK3b activity, stabilizing b-catenin, and affecting regulation of the cell cycle through Bmi-1 and cyclin D1., CCND1 showed 2.5-3.5 log reduction after chemotherapy and increase at relapse, The results suggested that HBZ suppressed cyclin D1 transcription through interactions with CREB., Matrine markedly suppresses cell proliferation in rhabdomyosarcoma cells by decreasing expression of cyclin D1 mRNA and blocking the cell cycle at the G0 / G1 stage., a novel activity for miR-206 in skeletal muscle differentiation. Cyclin D1 is identified as a major target that further strengthens the tumor suppressor function proposed for miR-206., Dosage of Dyrk1a repositions cells within a p21-CycD1 signaling map, directing each cell to either proliferate or to follow two distinct cell cycle exit pathways characterized by high or low CycD1 and p21 levels., T3 throid hormone enhanced the recruitment of the TRbeta1/Oct-1 complex on Octamer-transcription factor-1 site within cyclin D1 promoter., ATF-3 is involved in the progress of laryngeal squamous cell carcinoma, and may provide clinical information for evaluation of its prognosis. The oncologic role of ATF-3 may be correlated with Cyclin D1 regulation., DYRK1B is a novel Thr(286)-CCND1 kinase that acts independently of GSK3beta to promote CCND1 degradation., the prognostic value and the oncogenic function of NOTCH3 in gliomagenesis, Report CCND1 mutations in mammary analogue secretory carcinoma of salivary glands with high-grade transformation., CCND1 G870A polymorphism might be correlated with the susceptibility of oral cancer in Asians., the overexpression of cyclin D1 is almost always present in CIN1 of reproductive women, in which it might be considered as an additional diagnostic marker., An meta-analysis provides evidence of the association between CCND1 G870A polymorphism and nasopharyngeal carcinoma risk., miR-449a could modulate cell cycle and apoptosis through regulating cyclin D1 and BCL2 expression in gastric cancer cells., found and reviewed nine case-control studies on CCND1 G870A with a total of 6,823 subjects and seven studies on XPC Ala499Val with a total of 7,674 subjects, Cyclin D1 has a role in prostate cancer that involves coordinating restraint of epithelial-mesenchymal transition and stem cell expanding gene expression, Induction of Dicer by cyclin D1 coordinates microRNA biogenesis in breast cancer., These observations support hsa-miR-206 as a tumor suppressor in melanoma and identify Cyclin C, Cyclin D1, and CDK4 as miR-206 targets., This study uncovers the molecular mechanism of PRMT2 regulating the expression of CCND1 in invasive ductal breast carcinoma., Altered expression of cyclin D1 is associated with lymph node metastasis and risk of UCB recurrence. Cyclin D1 expression may therefore have clinical value as a prognostic marker and potential therapeutic target, SUMOylated RhoGDIalpha suppressed C-Jun/AP-1-dependent transactivation specifically via targeting MEK1/2-Erk, subsequently leading to the down-regulation of cyclin D1 expression and anti-cancer activity., Asymptomatic monoclonal B-cell lymphocytosis with cyclin D1 overexpression is characterized by immune activation and driven by inflammatory cues., Analysis of a cyclinD1 mRNA directly implicated HuR in regulating cyclinD1 production, cyclin D1 gene polymorphism CCND1 G870A is not associated with oral squamous cell carcinoma., Celecoxib showed considerable chemoprotective effeciency against BPDE in both groups and this effect seems to be independent of COX-2 expression. No evidence for higher mutagen sensitivity in the Cyclin D1 gene was observed, Expression of beta-catenin and cyclinD1 may be used as predict markers for poor prognosis in Ovarian serous cancer, forced expression of miR-490-3P decreased both mRNA and protein levels of CCND1, which plays a key role in G1/S phase transition, Urothelial bladder carcinoma displayed elevated expression for cyclin D1, VEGFA and TGFbeta1., Nucleoli are rich in nucleolin, a potent transcription factor that we found to bind sites within the Ccnd1 gene specifically in Mantle cell lymphoma cells and to activate Ccnd1 transcription., The prediction of CCND1 amplification by plasma DNA may be a new complementary clinical biomarker for recurrence in patients with superficial esophageal squamous cell carcinoma., No significant association was detected between CCDN1 G870A polymorphism and laryngeal squamous cell cancer development., We suggest that there is an association between cyclin D1 gene amplification and disease severity, unfavorable prognosis, and increased expression of MDR1 in multiple myeloma patients., High cyclin D1 expression is associated with laryngeal squamous cell carcinoma., These findings may provide a novel linkage between the EGFR and STAT3 signaling pathways and the activation of cyclin D1 by LMP1 in the carcinogenesis of NPC., miR-545 suppressed cell proliferation by inhibiting the expression of cyclin D1 and CDK4., It is thus inferred that gain in copy number of CCND1 is implicated in the molecular pathogenesis of parathyroid carcinoma., CCND1 G870A polymorphism may increase the risk of HBV-related hepatocellular carcinoma in the Chinese population., Cyclin D1 may represent a useful marker for monitoring long-term effects associated with exposure to low levels of radiation., Interaction of phosphorylated PRs with SP1 and cyclin D1 provides a mechanism for targeting transcriptionally active PRs to selected gene promoters relevant to breast cancer progression., Cyclin D1 expression increases in gliomas., Cyclin D1 and survivin may be used as molecular markers to predict the sensitivity of radiotherapy., GM-CSF accelerated the G1/S phase transition in EPCs by upregulating the expression of cyclins D1 and E., Our findings indicated that cyclin D1 expression correlates with detrimental clinicopathological outcome and poor prognosis in oral squamous cell carcinoma., we characterized 2 exceptional cases of blastoid B-cell lymphomas with cyclin D1 overexpression, both bearing genetic rearrangements in the CYCLIN D1 gene locus., The meta-analysis results indicated that cyclin D1 is an unfavorable prognostic factor for colorectal cancer., the present meta-analysis provides evidence that genotypes for the cyclin D1 (CCND1) G870A polymorphism may be not associated with genetic susceptibility of cervical cancer., SGK3 is an androgen receptor (AR) target and induces cell proliferation through the AR-SGK3-p70S6K-cyclin D1 pathway in prostate cancer cells., Our study showed that p53, p21, and cyclin D1 are frequently overexpressed in ampullary adenocarcinoma (AA). Cyclin D1 overexpression is associated with increased risk of disease recurrence and worse survival in patients with AA after resection., Aberrant expression of both cyclin D1 and CDC6 by YB-1 over-expression may collaboratively participate in lung carcinogenesis., Cyclin D1-specific CD8(+) T cells secreted TNF-alpha, IFN-gamma, and interleukin-2 (IL-2), and degranulated, indicating the presence of polyfunctional tumor-specific CD8(+) T cells in the blood of these patients with ccRCC., JunB expression was significantly increased while cyclin-D1 expression was significantly down-regulated in pre-eclampsia relative to control placental mesenchymal stromal cells., our results demonstrate a combined mechanism for the anti-proliferative effects of FRK by inhibiting cyclin D1 nucleus accumulation and pRb phosphorylation in glioma cells., DYRK1A reduced cellular Cyclin D1 levels by phosphorylation on Thr286, which is known to induce proteasomal degradation., CCND1 overexpression in non-habits associated anterior tongue carcinomas may contribute to their increased clinical aggressiveness., Cyclin D1 governs an essential role in the E2-dependent DNA damage response via a novel extranuclear function., CCND1 G870A polymorphism is a risk factor for the development of glioma, High cyclin D1 expression is associated with ovarian cancer., CCND1 amplification was seen in 28 of 133 (21.05 %) informative breast cancer patients. A discordant Cyclin D1 amplification status was detected in 6 out of 28 (21.43 %) amplified tumors., CCND1 G870A polymorphism may increase brain tumor risk, especially for gliomas. [Meta-Analysis], CCND1 in skin cancer cells is responsible for E2F1-mediated cell proliferation., Cyclin D has a role in activating the Rb tumor suppressor by mono-phosphorylation, While frequency rates of BRAF mutations were quite identical across the different MPM lesions, a significant increase of cKIT (p<0.001) and CyclinD1 (p=0.002) amplification rates was observed between first and subsequent primary melanomas, Report cyclin D1 expression in association with hormone replacement therapy and oral contraceptives risk in colorectal cancer., cyclin D1 and C/EBPbeta LAP1 operate in a common pathway to promote mammary epithelial cell differentiation., The differential effects of PKCalpha and PKC on cyclin D1 accumulation are likely to contribute to the opposing tumor-suppressive and tumor-promoting activities of these PKC family members in the intestinal epithelium., Expression levels of CCDN1 in large gastric hyperplastic polyps did not vary significantly between patients with gastric carcinoma and those without., miR-15b may function as a glioma suppressor by targeting the Cyclin D1, which may provide a novel therapeutic strategy for treatment of glioma, Expression of miR-34a was lower in metastases than in primary tumors. It inversely correlated with expression of cyclin D1 and Ki-67, GALR2-dependent activation of ERK1/2 is associated with cyclin D1 regulation but not with induction of apoptosis in head and neck squamous cell carcinoma cells., High Cyclin-D1 expression is correlated with significantly lower survival in oral squamous cell carcinoma patients., cyclin D1 overexpression and possibly p16 loss of expression in pancreatic adenocarcinoma seem to be adverse prognostic factors, A role of Notch1 signaling in activation of Cyclin D1-mediated cell proliferation in colon cancer., while there was overall a lack of any association between CCND1 polymorphisms (G870A and G1722C) and head and neck cancer (HNC) risk, smokers carrying the A allele and AA genotype of the CCND1 G870A polymorphism may be susceptible to HNC development., The expressions of HER-2/neu (c-erbB2), survivin and cycline D1 are positively correlated with the malignant potential of serous ovarian neoplasms., elevated protein expression of p53, cyclin D1 and Ki-67 in the second primary malignancy is an indicator of more aggressive malignant behavior of the secondary tumor, the present study indicates anti-tumor effects of cyclin D1b in cervical cancer, OCT4 is the upstream factor that directly binds to the CCND1 promoter to regulate CCND1 expression, then to promote cell cycle progression and accelerate the proliferation and invasion of esophageal cancer cells, TIP30-induced downregulation of cyclin D1 transcription antagonizes EGFR signaling and suppresses tumorigenesis, PSAT1 expression positively correlates with the levels of phosphorylated cyclin D1 in non-small cell lung cancer., CCND1 870G/A and CDH1 -160C/A SNPs may contribute to the etiology of colorectal cancer in South Indian population and carriers of the 870A/-160A haplotype have a higher risk for colorectal cancer susceptibility., CCND1 G870A polymorphism may increase risk of non-Hodgkin lymphoma, but not leukemia., Suggest a role for cyclin D1b as a possible mediator of alphavbeta3 transcription to promote breast tumor metastasis., CCND1 A870G genotypes, synergistically interacted with personal cigarette smoking habit and may increase the personal risk to gastric carcinogenesis in Taiwan., The CCND1 G870A polymorphism may contribute to the susceptibility to papillary thyroid cancer, especially in those who were older subjects (45 = years old) and female, in the Turkish population., SGC7901 cells with high levels of ER-a36 expression exhibited estrogen hypersensitivity, high growth rate and high levels of Cyclin D1 expression while SGC7901 cells with knocked-down levels of ER-a36 expression were insensitive to estrogen stimulation, Cyclin D1 expression was seen in 67.5% of ductal carcinoma and it showed a significant correlation with ER, PgR expression (92% in this study)., Immunohistochemical staining for DACH1, PCNA and cyclin D1 was performed on human renal tissue microarrays and correlation with clinic-pathological characteristics was analyzed., Data suggest that RKIP inhibits gastric cancer metastasis via the downregulation of its downstream target genes STAT3 and cyclin D1., Lefty1 could regulates the cell cycle via modulating the expressions of P57 and cyclin D1 and then inhibit the decidualization in vitro., Bcl1 polymorphism may be one of the genetic factors in predicting treatment response to SSRI but not SNRI in Japanese patients with depression., Our meta-analysis provides an estimate that the presence of cyclin D1 polymorphism may not confer susceptibility to breast cancer., Results from case-control study and meta-analysis suggested a significant association between the CCND1 G870A polymorphism and nasopharyngeal carcinoma risk in Chinese and Caucasians., Gene silencing of cyclin D1 leads to inhibition of the growth of head and neck squamous cell carcinoma cells., In summary, this study suggested that miR-383 plays the role of tumor suppressor by targeting CCND1 in glioma cells, and may be useful for developing a new therapeutic strategy for gliomas., CCND1 may be used as a prognostic biomarker for patients with resected gastric adenocarcinoma, High CCND1 expression is associated with pancreatic cancer., cyclin D1 and CDK4 protein interaction network was constructed in a human breast cancer cell line MCF7, and identified novel CDK4 protein partners., Expression of cycle marker cyclin D1 differs between benign and malignant papillary breast lesions., results indicate that high cyclin D1 expression is associated with a poor outcome of meningioma patients, increased expression of Cyclin D1 and Ki-67 in patients with endometrial carcinoma relative to proliferative endometrium and simple hyperplasia,.. Cyclin D1 expression had a positive correlation with Ki-67 expression., STAT3 and cyclinD1 correlate with more aggressive tumor behavior in esophageal squamous cell carcinoma. When STAT3 and cyclinD1 are considered together, they serve as effective prognostic markers in patients with surgically resected ESCC., Study identified the down-regulation of miR-576-3p in bladder cancer cell lines and reported that miR-576-3p, as a potential tumor suppressor in bladder cancer cells by targeting CCND1., The coexistence of IGH-CCND1 and IGH-BCL6 rearrangements suggest that BCL6 and cyclin D1 may cooperate in the pathogenesis of DLBCL., The increased expression of GSK3beta correlated positively with cyclin D1 and p53 expression., WWOX inhibits prostate cancer progression through negatively regulating cyclin D1 in cell cycle lead to G1 arrest., both amplification of CCND1 and protein overexpression of cyclin D1 significantly correlate with lymph node metastasis in oral squamous cell carcinoma, Data show that increased p53, together with deceased cyclin D1 and endoribonuclease DICER1 in mammospheres were responsible for microRNA let-7 inhibition., This HBx-induced cyclin D1 upregulation might play an important role in Hepatocellular carcinoma development and progression., Diclofenac and curcumin overcome these carcinogenic effects by downregulating telomerase activity, diminishing the expression of TERT, CDK4, CDK2, cyclin D1, and cyclin E., Cyclin D1 immunohistochemistry can be used in the differential diagnosis of clear cell sarcomas of the kidney., Notably cyclin D1 was strongly and diffusely expressed in all cases (20/20) of EWS/pPNET, while it was lacked in all cases (15/15) of rhabdomyosarcomas, results indicate that CD1 expression in childhood peripheral neuroblastic tumors recapitulates the changes during normal development of PSNS, Enterovirus 71 regulated the host SHSY5Y cell cycle and cell proliferation via stimulating endogenous miRNA let7b and directly targeting CCND1., Collectively, these data are the first to define the consequence of cyclin D1b expression on normal cellular function and present evidence for cyclin D1b as an oncogene., These findings support the concept that the cell cycle regulation may play a role in colorectal cancer initiation and development and CCND1 A870G genotyping maybe a feasible technology for colorectal cancer early detection, that re-introducing CDK6, cyclin-D1 or cyclin-D2 expression partially, but significantly, rescues cells from the suppression of cell proliferation and cell cycle arrest mediated by miR-340, CCND1 was identified as the target gene of miR-195, which functions as a osteosarcoma metastasis suppressor gene by down-regulating CCND1., Both cyclins D1a and D1b could promote cell proliferation, which might contribute to the potential oncogenic role of cyclin D1 variants during the precancerous cirrhotic stage of hepatocarcinogenesis, the high expression of TC1 was common in oral tongue squamous cell carcinomas and correlated with the expression of b-catenin and cyclin D1 and the progression of oral tongue squamous cell carcinomas, Data identified a subgroup of luminal-like breast cancer patients with a high risk of relapse and death harboring a combination of altered PPP2R2A and high CCND1 expression., The endoplasmic reticulum is well known to be a crucial regulator of plasma cell death and it plays the same role in their malignant counterparts, myeloma cells. This role involves activation of the UPR controlled at least in part by cyclin D1., CCND1 A870G polymorphism is not associated with prostate cancer risk., MiR-211 is a tumor suppressor that controls expression of Cyclin D1 and CDK6., Report cyclin D1 expression in well differentiated thyroid tumors of uncertain malignant potential., cyclin D1 and p27 have roles in statin-induced anti-proliferative effects in breast cancer, JARID2 inhibits leukemia cell proliferation by regulating CCND1 expression, Testing the oncogenic potential of catalytically inactive human cyclin D1 transduced in an in vivo knockout mouse model shows that the CDK-activating function of cyclin D1 is not necessary to induce either chromosomal instability or mammary tumorigenesis., Ectopic cyclin D1 reversed miR-95-3p-mediated inhibition of invasiveness and clonogenicity, demonstrating cyclin D1 downregulation is involved in function of miR-95-3p., miR-19a/Cyclin D1 axis might have promising applications as a therapeutic target and a prognostic marker for patients with hepatocellular carcinoma., Nuclear EGFR occurs in ameloblastomas in association with Cyclin D1 expression, knockdown of ILK inhibits glioma cell migration, invasion and proliferation through upregulation of E-cadherin and downregulation of cyclin D1. Our results suggest that ILK may serve as a promising therapeutic target for glioma., Overexpression of miR-503 in breast cancer cell lines reduced cell proliferation through inducing G0/G1 cell cycle arrest by targeting CCND1, cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor, cyclin D1 expression cooperates with KRAS and PTEN alterations in pathogenesis of NSCLC, and they could serve as potential multiple molecular markers for specific subgroups of NSCLC patients as well as prognostic markers for this type of cancer., DNA methylation changes in neuroblastoma affect not only promoters but also intragenic regions of the genome and target functional chromatin domains of development and cancer-related genes such as CCND1., mitotic stabilized ATF7 protein re-localizes onto chromatin at the end of telophase and contributes to induce the cyclin D1 gene expression., Marine steroids as potential anticancer drug candidates, the anti-proliferative effect of resibufogenin may be attributed to the degradation of cyclin D1 caused by the activation of GSK-3beta, A statistically significant lapatinib- and gefitinib-induced repression of cyclin D1, MMP9 and beta-catenin in CERV196 cells., The findings suggest that heritable CCND1 status may influence the risk of developing leukemia and hepatocellular carcinoma, and that more attention should be given to carriers of these susceptibility genes. (Meta-analysis), Our results suggest that the CCND1 G870A SNP may be critically involved in multiple myeloma development, our data demonstrate that miR-193b targets cyclin D1 in prostate cancer., ZIP5 knockdown inhibited the proliferation, migration and invasion of ESCC and suppressed COX2, cyclin D1 and E-cadherin expression, which led to the inhibition of cell progression in esophageal squamous cell carcinoma ., Cyclin D1 Again Caught in the Act, CCND1-CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem cells in vivo., In G28 cells, a dosedependent induction of CDK2, p21 and cyclin D was observed between 10 and 50 microM roscovitine after 72 h, however, at the highest concentration of 100 microM, all investigated genes were downregulated., mechanistic study of the molecular interactions between antizyme inhibitor and its interacting proteins CCND1 and ornithine decarboxylase, Describe microcystic stromal tumor as a distinctive ovarian sex cord-stromal neoplasm characterized by FOXL2, SF-1, WT-1, Cyclin D1, and beta-catenin nuclear expression and CTNNB1 mutations., same down-regulation of cohesin targets is observed in SMC1A-mutated patient fibroblasts, It is a marker of oligodendrocyte precursor cells in oligodendroglial tumors., Cyclin D1 loss identifies prostate tumors with small-cell differentiation and may identify a small subset of adenocarcinomas with poor prognosis., CREB activation may contribute to the induction of Ccnd1 expression through binding to the Ca/CRE element in the Ccnd1 gene promoter., RNAi-mediated silencing of Anxa2 inhibits breast cancer cell proliferation by downregulating cyclin D1 in STAT3-dependent pathway., Case Report, Ewing sarcoma cells require CDK4 and cyclin D1 for survival and anchorage-independent growth., Both fenhexamid and cyprodinil may increase cancer cell proliferation by stimulating the protein expressions of cyclin D1 and cyclin E., Downregulation of microRNA33a promotes the expression CDK6, CCND1, and PIM1, and gastric cancer cell proliferation., There is a significant upregulation of cyclin D1 in Ewing's sarcoma as compared to normal tissues., showed that CCND1 and CDK4 mutations are associated with an increased risk of breast cancer, Data indicate that 2-Chloroadenosine reduced levels of cyclin D1, a key G1 cyclin that controls cell-cycle progression., Results confirm that CEACAM6 promoted cell proliferation mediated by cyclin D1/CDK4., Neuroblastoma is associated to significantly higher levels of cyclin D1 as compared to both ganglioneuroma and ganglioneuroblastoma., FH535 suppressed the proliferation of HCC cells by downregulating the expression of cyclin D1 and by inducing apoptosis, Study suggests that cyclin D1 may be an independent prognostic factor for recurrence-free survival in stage II-IIIA adenocarcinoma of lung., Data show that Cyclin D1 has a higher expression in breast cancer, positively correlated with estrogen receptors (ER) and better prognosis., Analysis of ctal carcinoma in situ (DCIS) by grade suggested that two independent SNPs near CCND1 were specific to low/intermediate grade DCIS . These associations with grade remained after adjusting for ER status and were also found in IDC, BRAF inhibitor therapy-associated melanocytic lesions lack the BRAF V600E mutation and show increased levels of cyclin D1 expression.,
OFFICIAL_GENE_SYMBOL CCND1,
OMIM_DISEASE Colorectal cancer, susceptibility to, von Hippel-Lindau syndrome, modifier of, Multiple myeloma, susceptibility to,
SP_COMMENT disease:A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma (MCL). Translocation t(11;14)(q13;q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle., disease:A chromosomal aberration involving CCND1 may be a cause of multiple myeloma [MIM:254500]. Translocation t(11;14)(q13;q32) with the IgH locus., disease:A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas [MIM:168461]. Translocation t(11;11)(q13;p15) with the parathyroid hormone (PTH) enhancer., function:Essential for the control of the cell cycle at the G1/S (start) transition., online information:The Singapore human mutation and polymorphism database, PTM:Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31. Ubiquitination leads to its degradation and G1 arrest., PTM:Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex., similarity:Belongs to the cyclin family., similarity:Belongs to the cyclin family. Cyclin D subfamily., subunit:Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.,