Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)(RAC3) ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)(RAC3) Related Genes Homo sapiens
CHROMOSOME 17,
CYTOBAND 17q25.3,
ENSEMBL_GENE_ID ENSG00000169750,
GENERIF_SUMMARY Our data is the first report of the frequency of Rac3 overexpression and mutation in human brain tumors. Overexpression may be associated with aggressive tumor behavior, functional analysis of Rac1 and Rac3 using RNA interference reveals a critical role for these GTPases in the invasive behavior of glioma and breast carcinoma cells, results suggest a role for both the Rac1 and Rac3 GTPases in human breast cancer progression, RAC1 and RAC3 have opposing functions in cell adhesion and differentiation in neuronal cells., Data demonstrate that Rac3 shares with Rac1 the ability to interfere with cadherin-mediated adhesion., Rac3 inhibits adhesion and differentiation of neuronal cells by modifying GIT1 downstream signaling., RAC3 is a novel ERalpha co-activator that promotes cell migration and has prognostic value for ERalpha-positive breast cancer metastasis., Rac3 GTPase has a role in the regulation of autophagy, RAC3 bound tightly to the ARE enhancer region of the HO-1 promoter via Nrf2 binding., Activation of epithelial-mesenchymal transition by MMP-induced expression of Rac1b gave rise to lung adenocarcinoma., Rac1b forms a complex with NADPH oxidase and promotes the production of reactive oxygen species, expression of Snail, and activation of the epithelial-mesenchymal transition program., Hypoxia inhibits the RAC3 gene expression leading to the autophagy process, allowing tumor cells to survive until angiogenesis occurs, Report role of Rac3 in breast cancer aggressiveness and show the potential usefulness of Rac3 depletion in breast cancer therapy., Collectively these data unveil that FBXL19 functions as an antagonist of Rac3 by regulating its stability and regulates the TGFbeta1-induced E-cadherin down-regulation., Efficient silencing of Rac3 strongly inhibited A549 cell proliferation., RAC3 is an inhibitor of senescence whose downregulation in aged individuals could be probably a tumor suppressor mechanism.,
SP_COMMENT function:Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles., induction:Expression down-regulated in quiescent fibroblasts and clearly induced by serum stimulation., similarity:Belongs to the small GTPase superfamily. Rho family., subcellular location:Membrane-associated when activated. Co-localizes with NRBP to endomembranes and at the cell periphery in lamellipodia., subunit:Interacts with the GEF protein DOCK7, which promotes the exchange between GDP and GTP, and therefore activates it. Interacts with C1D., tissue specificity:Highest levels in brain, also detected in heart, placenta and pancreas.,