Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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nectin cell adhesion molecule 2(NECTIN2) nectin cell adhesion molecule 2(NECTIN2) Related Genes Homo sapiens
CYTOBAND 19q13.2,
GENERIF_SUMMARY Regions of nectin-2 protein important for herpesvirus entry activity and homotypic nectin-nectin interactions are overlapping but not identical., Data show that both PVR and Nectin-2 represent specific ligands for the DNAM-1 triggering receptor., differences in the N termini of herpes simplex virus type 1 and 2 gDs that influence functional interactions with the human entry receptor Nectin-2, Analysis of the ligands for triggering NK receptors revealed the consistent expression of cd155 and cd112 in myeloid leukemias, and less frequent expression in lymphoblastic leukemias, There is an allelic association of sequence variation in PVRL2 and the severity of multiple sclerosis., CD226/CD112 (DNAM-1/Nectin-2) mast cell stimulation has a role in the allergic process, no statistically significant association between this marker allele and non-syndromic clefting, identified PVRL2 as a new recurrent partner gene of the TRA@ locus in peripheral T-cell lymphoma, Crystallization and preliminary X-ray analysis of the V domain of human nectin-2 are reported., TIGIT is expressed by all NK cells, it binds PVR and PVRL2 but not PVRL3, and it inhibits NK cytotoxicity, The authors now show that human cytomegalovirus targets CD112 for proteasome-mediated degradation by 48 h post-infection, thus removing both activating ligands for DNAM-1 from the cell surface during productive infection., The CD112 is highly expressed in colon carcinoma tissues and cell lines., a possible etiologic role of PRR2 in nonsyndromic cleft lip with or without cleft palate, Data show that a high expression of CD112 and CD155 (DNAM-1 ligands) on leukemic blasts., Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion., Chorionic gonadotropin induces vascular endothelial growth factor (VEGFA)-dependent downregulation of nectin 2, which increases the endothelial permeability in the coculture system., Nectin-3 trans-interacts with Nectin-2 to promote lymphocyte and monocyte extravasation., PVRL2, TOMM40 and APOE might be associated with human longevity., Soluble form of nectin-2 is required for exerting the resistance against HSV-2 infection.,
SP_COMMENT function:Probable cell adhesion protein., similarity:Belongs to the nectin family., similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain., similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains., subunit:Can form trans-heterodimers with PVRL3/nectin-3 (By similarity). Interacts with CD226. Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells. Binds with low affinity to TIGIT., tissue specificity:Ubiquitous.,