Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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protein tyrosine phosphatase, receptor type M(PTPRM) protein tyrosine phosphatase, receptor type M(PTPRM) Related Genes Homo sapiens
CYTOBAND 18p11.2,
GENERIF_SUMMARY interactions between RPTP-domain1s and RPTP-domain 2s are a common but specific mechanism that is likely to be regulated- domain2s and the wedge structures are crucial determinants of binding specificity, thus regulating cross-talk between RPTPs, RPTPmu may play a role in the regulation of cardiovascular functions, PTPmu may regulate Rho-GTPase-dependent functions of IQGAP1, a 3.1 angstrom crystal structure of the RPTPmu ectodomain that forms a homophilic trans (antiparallel) dimer with an extended and rigid architecture, matching the dimensions of adherens junctions is described, BCCIP is phosphorylated by the Src tyrosine kinase and dephosphorylated by the PTPmu tyrosine phosphatase; neurite outgrowth assays suggest that BCCIP and PTPmu are in a common signal transduction pathway., Loss of protein tyrosine phosphatase receptor type mu is associated with glioma cell migration and progression., loss of cell surface PTPmu by proteolysis generates catalytically active PTPmu fragments that contribute to migration and survival of glioblastoma cells, In A549 cells, diverse injurious stimuli dramatically reduced PTPmu protein expression., Results suggest that miR-221 and -222 regulate glioma tumorigenesis at least in part through the control of PTPmu protein expression., Loss of PTPmu by proteolysis causes glioblastoma., Decreased expression of PTPRM in breast cancer is correlated with poor prognosis and inversely correlated with disease-free survival., Study determined that, in addition to the furin-processed form of PTPmicro, a pool of 200 kDa full-length PTPmicro exists at the plasma membrane that is cleaved directly by ADAM to generate a larger shed form of the PTPmicro extracellular segment.,
SP_COMMENT catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate., function:Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control., similarity:Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily., similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain., similarity:Contains 1 MAM domain., similarity:Contains 1 tyrosine-protein phosphatase domain., similarity:Contains 2 tyrosine-protein phosphatase domains., similarity:Contains 4 fibronectin type-III domains.,