Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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protein tyrosine phosphatase, receptor type F(PTPRF) protein tyrosine phosphatase, receptor type F(PTPRF) Related Genes Homo sapiens
GENERIF_SUMMARY regulation of expression by cell density through functional E-cadherin complexes, interactions between RPTP-domain1s and RPTP-domain 2s are a common but specific mechanism that is likely to be regulated- domain2s and the wedge structures are crucial determinants of binding specificity, thus regulating cross-talk between RPTPs, LAR PTPase domains play distinct functional roles in phosphorylation and dephosphorylation, LAR as a crucial regulator of the sensitivity of two key insulin signalling pathways to insulin, Results identify a protein tyrosine phosphatase as a potential substrate of TACE and describe proteolytic processing of PTP-LAR as a means of regulating phosphatase activity downstream and thus under the control of EGFR-mediated signaling pathways., PS/gamma-secretase-mediated cleavage of LAR controls LAR-beta-catenin interaction, suggesting an essential role for PS/gamma-secretase in the regulation of LAR signaling, Regulated degradation of liprinalpha1 is important for proper LAR receptor distribution, and could provide a mechanism for localized control of dendrite and synapse morphogenesis by activity and CaMKII., LAR and Src are identified as Death-associated protein kinase (DAPK) regulators through their reciprocal modification of DAPK Y491/492 residues and establishes a functional link of this DAPK-regulatory circuit to tumor progression., the PTPase activity in patients with insulin receptor gene mutation and severe insulin resistance may differ from that in ordinary type 2 diabetes, LAR functions as a negative regulator of adipogenesis., Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation., Interaction between the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses., PTPRF is down-regulated in hepatocellular carcinoma-facilitated tumor development., Homozygous truncating PTPRF mutation causes athelia., PTPRF may have value as a predictive marker to identify which patients can obtain the greatest benefit from erlotinib in the post-first-line setting.,
OMIM_DISEASE Breasts and/or nipples, aplasia or hypoplasia of, 2,
SP_COMMENT catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate., function:Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase)., function:The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one., similarity:Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily., similarity:Contains 2 tyrosine-protein phosphatase domains., similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains., similarity:Contains 8 fibronectin type-III domains., subunit:Interacts with GRIP1 (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA3.,