Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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protein tyrosine phosphatase, receptor type B(PTPRB) protein tyrosine phosphatase, receptor type B(PTPRB) Related Genes Homo sapiens
CYTOBAND 12q15-q21,
GENERIF_SUMMARY The PTP1B has been observed over expressed in human breast cancer patients, suggesting its role in cell proliferation., the Ser127Gly polymorphism in PTPRB is associated with substance abuse vulnerability in three independent case-control samples, but was not associated with alcoholism in Japanese subjects, These results reveal a novel role for HPTPbeta in modulating Ang-1-Tie2 signaling and endothelial cell survival., vascular endothelial protein tyrosine phosphatase contributes to endothelial morphogenesis. Silencing of VE-PTP expression was accompanied by increased VEGF receptor-2 tyrosine phosphorylation and activation of downstream signaling pathways., Suggest that VE-PTP, in cooperation with integrins, regulates the spreading and migration of endothelial cells during angiogenesis., zinc(II) ions regulate receptor protein-tyrosine phosphatase beta activity at picomolar concentrations., these results suggest that the polarized redistribution of VE-PTP in response to shear stress plays an important role in the regulation of endothelial cells function by blood flow., The endothelial phosphatase PTPRB, a negative regulator of vascular growth factor tyrosine kinases, harbored predominantly truncating mutations in 10 of 39 angiosarcoma tumors., Results provide evidence that PTPRB and PLCG1 mutations are driving events in a subset of secondary angiosarcomas., VE-PTP activates TIE2 and stabilizes retinal and choroidal blood vessels,
SP_COMMENT catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate., similarity:Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily., similarity:Contains 1 tyrosine-protein phosphatase domain., similarity:Contains 17 fibronectin type-III domains., subunit:Interacts with MAGI3.,