Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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mitogen-activated protein kinase 11(MAPK11) mitogen-activated protein kinase 11(MAPK11) Related Genes Homo sapiens
CHROMOSOME 22,
CYTOBAND 22q13.33,
ENSEMBL_GENE_ID ENSG00000185386,
GENERIF_SUMMARY p38 MAP Kinase suppresses the function of Mirk as a transcriptional activator only when cells are proliferating, the p38MAPK activation-Bax expression pathway might be involved in apoptosis induced by oxidative stress, Neurotoxicity of pneumolysin depends on activation of p38 mitogen-activated protein kinase., activation of p38 MAPK is involved in the mitochondrial activation-mediated cell death pathway, Activities of aPKC (P<0.05) and ERK 1/2 (P=0.06), but not phosphorylation of P38 MAPK, were higher in trained than in sedentary subjects at rest., SAPK2/p38 intervenes in the control of MonoMac6 cell migration induced by monocyte chemoattractant protein-1., phosphorylation of Y1214 on VEGFR2 is required to trigger the sequential activation of Cdc42 and SAPK2/p38 and to drive the SAPK2/p38-mediated actin remodeling in stress fibers in endothelial cells exposed to VEGF, These results suggest that bFGF can negatively modulate p38 and positively modulate ERK1/2 to antagonize activin A-mediated growth inhibition and Hb synthesis in K562 cells., SAPK2/p38 mitogen-activated protein kinase is inhibited by PML in tumor cells, cholesterol depletion alters involucrin gene expression through activation of p38alpha/beta., p38SAPK might be involved in the regulation of cyclin D3 levels and suggest that this mechanism is involved in the maturation of precursor T-cells, p38alpha and -beta mediate UV-induced, AP-1-mediated, c-Fos phosphorylation, p38 phosphorylation occurred in response to attack by Staphylococcus aureus alpha-toxin and streptolysin O, commencing within minutes after toxin treatment and waning after several hours., The authors characterized the multisite phosphorylation of the ATF7 activation domain and identified one of the involved kinase, p38beta2 mitogen-activated protein kinase., genistein protects human vascular endothelial cells against tumor necrosis factor-alpha-induced apoptosis through the p38beta mitogen-activated protein kinase, Specific isoforms of p38 and their sub-cellular localization may have different roles in modulating ischemic injury., results demonstrate that IFN-alpha can regulate growth inhibition of Jurkat cells through p38alpha and p38beta, These results demonstrate that activin A induces erythroid differentiation of K562 cells through activation of MKK6-p38alpha/p38beta pathway and follistatin inhibits those effects., show that p38 MAP kinase directly activates TACE and effects shedding in response to growth factors and Erk MAP kinase activation., p38alpha/p38beta and phosphoinositide 3-kinase are crucial to Tat-induced IL-10 production, Overexpression of p38beta or Rac1 significantly enhanced (1.9- and 3.9-fold, respectively), the tRA-stimulated NIS expression in MCF-7 cells., Thus, in endothelial cells p38alpha mediates apoptotic signaling, whereas p38beta and p38gamma transduce survival signaling, Study identifies Hsp27 as a novel target of ILK-p38beta signaling complexes, playing a key role in bladder cancer cell migration., inhibition of the SOCE downstream target CaM kinase kinase beta (CaMKKbeta) or knockdown of AMPKalpha1 suppressed PAR-1-mediated phosphorylation of p38beta and hence STIM1., p38beta is a novel regulatory target of the transcription factor Pokemon and positively regulated by Pokemon in hepatic cells., Differential roles for p38alpha and p38beta in the HGF-induced expression of key osteogenic markers., study identified the structural motif responsible for the unique autophosphorylation capability of p38beta and the motif inhibiting this activity in living cells, Data show that the p38 MAPK (p38) isoform (p38beta) mitogen-activated protein kinase 11 (MAPK11) is expressed in breast cancer cell., The MAPK11 gene was variably methylated in monozygotic twins discordant for depressive disorder., These findings suggest that coronin 1A modulates endothelial cell apoptosis by regulating p38beta expression and activation., Suggest that R-Ras regulates angiogenic activities of endothelial cells in part via inhibition of the p38MAPK-HSP27 axis of VEGF signaling.,
OFFICIAL_GENE_SYMBOL MAPK11,
SP_COMMENT catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases., enzyme regulation:Activated by phosphorylation on threonine and tyrosine by MKK6. Inhibited by pyridinyl-imidazole related compounds., function:Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. Phosphorylates preferentially transcription factor ATF2., PTM:Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme., similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily., similarity:Contains 1 protein kinase domain., tissue specificity:Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas.,
mitogen-activated protein kinase 12(MAPK12) mitogen-activated protein kinase 12(MAPK12) Related Genes Homo sapiens
CHROMOSOME 22,
CYTOBAND 22q13.33,
ENSEMBL_GENE_ID ENSG00000188130,
GENERIF_SUMMARY C-terminal halves of ERK2 and ERK3DeltaC are primarily responsible for subcellular localization in resting cells; and the N-terminal folding domain of ERK2 is required for its activation in cells, interaction with MEK1, and accumulation in the nucleus, Cardiac expression and subcellular localization, IL-2 and polysaccharide K increased the expression of ERK3., CRM1 binds to ERK3and promotes the cytoplasmic relocalization of ERK3. Enforced localization of ERK3 in the nucleus or cytoplasm markedly attenuates the ability of the kinase to induce cell cycle arrest in fibroblasts., data suggest that p38gamma increases basal glucose uptake and decreases DNP- and contraction-stimulated glucose uptake, partially by affecting levels of glucose transporter expression in skeletal muscle, SAPK3 phosphorylates mitochondrial protein Sab, Data show that in response to radiation, MRK controls two independent pathways, hyperactive variants of p38alpha induce, whereas hyperactive variants of p38gamma suppress, activating protein 1-mediated transcription, Mapk14 antagonizes Mapk12 activity through c-jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response., These results suggest that, in SupT1-based cell lines, p38alpha, p38gamma and p38delta, but not p38beta, are implicated in both HIV-1 induced replication and apoptosis in infected and uninfected bystander cells., p38alpha and p38gamma are essential components of the signaling pathway that regulates the tumor-suppressing senescence response, PTPH1 plays a role in Ras-dependent malignant growth of colon cancer by a mechanism depending on its p38gamma-binding activity., In response to hyperosmotic stress, p38 also regulates formation of complexes between hDlg and PSF., Isoforms of p38MAPK gamma and delta contribute to differentiation of human AML cells induced by 1,25-dihydroxyvitamin D., The majority of p38gamma-depleted cells die at mitotic arrest or soon after abnormal exit from M-phase., demonstrates that p38gamma MAPK is a promising target for the design of targeted therapies for basal-like breast cancer with metastatic characteristics and for overcoming potential resistance against the PARP inhibitor, p38gamma mitogen-activated protein kinase regulates breast cancer cell motility and metastasis, in part, by controlling expression of the metastasis-associated small GTPase RhoC., a new paradigm in which p38gamma actively regulates the drug-Topo IIalpha signal transduction, and this may be exploited to increase the therapeutic activity of Topo II drugs., phosphorylation at Ser-118 is required for ER to bind both p38gamma and c-Jun, thereby promoting ER relocation from ERE to AP-1 promoter sites., Thus, in endothelial cells p38alpha mediates apoptotic signaling, whereas p38beta and p38gamma transduce survival signaling, p38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response., SEPW1 silencing increases MKK4, which activates p38gamma, p38delta, and JNK2 to phosphorylate p53 on Ser-33 and cause a transient G(1) arrest., analysis of how allosteric regulation of p38gamma and PTPN3 involves a PDZ domain-modulated complex formation, Taken together our data suggest that as cells initiate adhesion to matrix increasing levels of ERK3 at the cell periphery are required to orchestrate cell morphology changes which can then drive migratory behavior., during interphase ERK3 is mainly resident in the nucleoplasm in association with ribonuclear proteins involved in early pre-mRNA splicing, it undergoes cell cycle-dependent redistribution and, during apoptosis, p38gamma and p38delta reprogram liver metabolism by modulating neutrophil infiltration and provide a potential target for NAFLD therapy,
OFFICIAL_GENE_SYMBOL MAPK12,
SP_COMMENT catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Binds 2 magnesium ions., domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases., enzyme regulation:Activated by phosphorylation on threonine and tyrosine., function:Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation., PTM:Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme., similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily., similarity:Contains 1 protein kinase domain., subcellular location:Mitochondrial when associated with SH3BP5., subunit:Monomer. Interacts with the PDZ domain of the syntrophin SNTA1. Interacts with SH3BP5., tissue specificity:Highly expressed in skeletal muscle and heart.,
mitogen-activated protein kinase 13(MAPK13) mitogen-activated protein kinase 13(MAPK13) Related Genes Homo sapiens
CHROMOSOME 6,
CYTOBAND 6p21.31,
ENSEMBL_GENE_ID ENSG00000156711,
GENERIF_SUMMARY Novel protein kinase C isoforms regulate human keratinocyte differentiation by activating a p38 delta mitogen-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha, p38 has a role in mediating induction of VEGF mRNA expression by sodium arsenite, observations suggest that p38 delta is the major p38 isoform driving suprabasal hINV gene expression and that p38 delta directly regulates ERK1/2 activity via formation of a p38 delta-ERK1/2 complex, p38delta mitogen-activated protein kinase as a downstream carrier of the PKCdelta-dependent death signal in keratinocytes, sapk4 activation mediates apoptosis and neurodegeneration in infantile neuronal ceroid lipofuscinosis, activation of p38 isoforms by hypertonicity does not contribute to activation of TonEBP/OREBP because of opposing effects of p38alpha and p38delta., These results suggest that, in SupT1-based cell lines, p38alpha, p38gamma and p38delta, but not p38beta, are implicated in both HIV-1 induced replication and apoptosis in infected and uninfected bystander cells., results indicate that p38delta is important for motility and invasion of CC cells, suggesting that p38delta may play an important role in CC metastasis., Function of p38delta in regulating of epidermal keratinocyte differentiation, apoptosis and skin tumor development, is discussed., Taken together, the data indicate that the respective stress-dependent action of p38 isoforms is responsible for the up-regulation of the gene expression of the chemokine BRAK/CXCL14., Isoforms of p38MAPK gamma and delta contribute to differentiation of human AML cells induced by 1,25-dihydroxyvitamin D., PRMT5 inhibits the PKCdelta- or 12-O-tetradecanoylphorbol-13-acetate-dependent increase in human involucrin expression, and PRMT5 dimethylates proteins in the p38delta complex., SEPW1 silencing increases MKK4, which activates p38gamma, p38delta, and JNK2 to phosphorylate p53 on Ser-33 and cause a transient G(1) arrest., MAPK13 is responsible for IL-13-driven mucus production in human airway epithelial cells., DNA methylation alterations are widespread in melanoma; epigenetic silencing of MAPK13 contributes to melanoma progression, esophageal squamous cell carcinoma cell lines which are p38delta-negative grew more quickly than cell lines which express endogenous p38delta., GSK3alpha, GSK3beta, and MAPK13 were found to be the most active tau kinases, phosphorylating tau at all four epitopes., Data indicate that p38delta mediates oncogene-induced senescence through a p53- and p16(INK4A)-independent mechanism., PKCdelta activates a MEKK1/MEK3/p38delta MAPK cascade to increase p53 levels and p53 drives p21(Cip1) gene expression., MAPK13 undergoes a larger interlobe configurational rearrangement upon activation compared with MAPK14., p38gamma and p38delta reprogram liver metabolism by modulating neutrophil infiltration and provide a potential target for NAFLD therapy, MAPK13 gene knockdown using siRNA reduced the aldehyde dehydrogenase high cell population and abrogated the tumor-initiating ability.,
OFFICIAL_GENE_SYMBOL mapk13,
SP_COMMENT catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases., enzyme regulation:Activated by phosphorylation on threonine and tyrosine by either of two dual specificity kinases, MAP2K3 and MAP2K6., function:Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K., PTM:Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme., similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily., similarity:Contains 1 protein kinase domain., tissue specificity:Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells.,
mitogen-activated protein kinase 14(MAPK14) mitogen-activated protein kinase 14(MAPK14) Related Genes Homo sapiens
CHROMOSOME 6,
CYTOBAND 6p21.3-p21.2,
ENSEMBL_GENE_ID ENSG00000112062,
ENTREZ_GENE_ID 1432,
GENERIF_SUMMARY PI3K promotes assembly of adherens junctions, which, in turn, control p38 MAPK activation and enterocyte differentiation., p38 Map kinase pathway is a common effector for type I IFN and transforming growth factor beta signaling in human hematopoietic progenitors and plays a critical role in the induction of the suppressive effects of these cytokines on normal hematopoiesis, endotoxemia induced a phosphorylation and activation of p38 MAPK, mediates the cell death induced by PrP106-126, TRAIL/Apo2L-induced apoptosis is mediated by ROS-activated p38 MAP kinase followed by caspase activation in HeLa cells., allosteric binding site for a diaryl urea class of highly potent and selective inhibitors against human p38 MAP kinase, p38alpha MAP kinase is significantly activated in the inflamed colonic mucosa of Crohn's disease patients and is linked to the induction of TNF-alpha secretion and signaling in this system., involvement of P38 MAPK, AP-1 and NF-kappa B transcription factors in the IL-1 induction of MMPs in chondrocytes, Specificity of arachidonic acid-induced inhibition of growth and activation of c-jun kinases and p38 mitogen-activated protein kinase in hematopoietic cells, Activation of p38 mitogen-activated protein kinase and nuclear factor-kappaB in tumour necrosis factor-induced eotaxin release of human eosinophils., UVB-mediated activation of p38 mitogen-activated protein kinase enhances resistance of normal human keratinocytes to apoptosis by stabilizing cytoplasmic p53., Distinct roles for phosphoinositide 3-kinase, mitogen-activated protein kinase and p38 MAPK in mediating cell cycle progression of breast cancer cells., P38 MAPK has a role in inducing IL-8 gene transcription via AP-1 activation in hVSMCs, activation of this stress-associated pathway has been reported for many stimuli, a unique translocation of p38 from the cytoplasm to the detergent-resistant fraction is a specific event during hapten-induced activation of antigen-presenting cells., parthenolide inhibits LPS- but not TNF-alpha-induced maturation of human monocyte-derived dendritic cells by inhibition of the p38 mitogen-activated protein kinase pathway, both Ca(2+)-dependent and p38 kinase-mediated phosphorylation events, causes reassembly of the actin cytoskeleton and subsequent appearance of membrane blebs at the plasma membrane., ITGB1 activated by ERK1/2, p38 MAPK after hypoxia, p38 MAPK has a role in STAT1 dependent trans activation independent of serine phosphorylation, As(2)O(3) is able to induce the apoptotic activity in K562 cells, and its apoptotic mechanism may be associated with the activation of p38., there is a mechanically coupled transcriptional circuit that activates p38, tethers p38 to actin filaments, and promotes binding of p38 to Sp1 in the nucleus, p38 play a critical role in the UVA-induced expression of COX-2 in keratinocytes and may serve as a potential drug target in the chemoprevention of skin cancer., p38 MAP Kinase suppresses the function of Mirk as a transcriptional activator only when cells are proliferating, p38 alpha is regulated by TauAlphaBeta1beta in physiological conditions, p38MAPK and caspase are required for zinc-induced apoptosis in human leukemia HL-60 cells, JNK-1 and p38 play a role in apoptosis induced by capsaicin in H-ras-transformed tumor cells, data suggest that thrombin induces p38 mitogen-activated protein kinase activation, which leads to NF-kappa B mobilization to the nucleus and causes the upregulation of E-selectin and subsequent leukocyte recruitment, p38 MAP kinase is involved in a positive feedback loop regulating macrophage signaling with MKK6, p38 signaling is down-regulated in postinjury circulating neutrophils, p38 mitogen-activated protein kinase defines the common senescence-signaling pathway., Lipopolysaccharide stimulates p38-dependent induction of antiviral genes , such as myxovirus resistance-1 (MX1) in neutrophils independently of paracrine factors., upregulation of the p38 mitogen-activated protein kinase pathway might contribute to the loss of GLUT4 protein expression observed in adipose tissue from type 2 diabetic patients, activated p38 MAPK pathway may play a role in the pathogenesis of peritoneal fibrosis., p38 MAPK activation is central to IL-10 production of cells from patients with schistosomiasis mansoni and the levels of phosphorylated p38 MAPK influences the amount of Il-10 produced in cells from intestinal and hepatosplenic patients, p38 and ERK1/2 have roles in coordinating cellular migration and proliferation in epithelial wound healing, This additivism, where doxorubicin acts via p53 expression and vinorelbine through p38 MAP KINASE activation, may contribute to the high clinical response rate when the two drugs are used together in the treatment of breast cancer., results indicate that epithelial TLR5 mediates p38 activation and subsequently regulates flagellin-induced IL-8 expression independently of NF-kappaB, probably by influencing IL-8 mRNA translation, These findings suggested that reduction of the p38 MAPK cascade may account, in part, for the resistance to apoptosis, leading to the unrestricted cell growth of human HCC., Results suggest that tissue or plasma fibronectin may modulate the intestinal epithelial response to repetitive deformation through inhibted activation of p38 and jun kinases., p38 has a role in apoptosis in human melanoma cells by modulating depolarization of mitochondrial membrane potential, p38 MAPK pathway predominantly regulates deadenylation, rather than decay of the mRNA body, transforming growth factor-beta promotes osteoclastogenesis in monocytes by stimulation of the p38 mitogen activated protein kinase but continuous exposure abrogates osteoclastogenesis by down-regulation of receptor activator of NF-KB(RANK) expression, p38 is selectively activated by the new subfamily of Ste20-like kinases., p38 MAPK is activated at early stages of neurofibrillary degeneration in AD hippocampus. The p38 activation may also be linked to neurodegeneration through mechanisms other than neurofibrillary tangle formation, p38alpha regulates activation of downstream effectors that participate in the induction of IFN-dependent gene transcription to mediate IFN-responses, TAB1 participates in a SAPK2a/p38alpha-mediated feedback control of TAK1, p38 MAPK modulates STAT1 phosphorylation in IFN-gamma signaling in fetal brain astrocytes., epidermal p44/42 and p38 mitogen-activated protein kinases are activated by acute cutaneous barrier disruption, Pressure distension of intact human saphenous vein induces activation of p38, and this is associated with apoptosis. Inhibition of p38 kinase activity in saphenous vein smooth muscle cells and intact vein reduces apoptosis., p38-MAPK can directly phosphorylate and inhibit the activities of caspase-8 and caspase-3 and thereby hinder neutrophil apoptosis, and, in so doing, regulate the inflammatory response., activation of p38MAPK might contribute significantly to the pathology of motor neurons in ALS., dual signaling pathways involving TGF-beta1, an antiapoptotic pathway mediated by the Smad pathway involving p21, and an apoptosis-permissive pathway mediated in part by p38 MAPK., p38alpha and Smad signaling pathways have roles in MSK1-mediated transforming growth factor-beta-mediated responses, MIF activates rheumatoid arthritis COX-2 and IL-6 expression via p38 MAP kinase activation and induces IL-8 via p38 and ERK MAP kinase-independent pathways., Increased p38 MAPK signalling is a feature of human and experimental diabetic nephropathy, dual effect of UVB, to stimulate maturation or to induce apoptosis in monocyte derived dendritic cells, depending on the dosage, via p38 MAPK pathway., cAMP concentration in endothelial cells prevents thrombin-induced ICAM-1 expression by inhibiting p38 MAPK activation, which in turn prevents phosphorylation of RelA/p65 and transcriptional activity of the bound NF-kappaB., PMA-induced activations of ERK and p38 kinase are parallel events that are both required for inhibition of NO-induced death of Molt4 cells, endotoxin increases sTRAIL where the p38 MAP kinase signaling pathway is involved, active p38 mutants emulate the conformational changes imposed naturally by dual phosphorylation, ERK suppresses stress-induced apoptosis downstream of mitochondrial alterations by maintaining XIAP levels and oxidants block this effect through activation of p38 and protein phosphatases, Suppression of glucocorticoid receptor function by activated p38 may be important as a mechanism of resistance to glucocorticoids seen in many patients with chronic inflammatory conditions., cholesterol depletion alters involucrin gene expression through activation of p38alpha/beta., RANKL-induced cathepsin K gene expression is cooperatively regulated by the combination of the transcription factors and p38 MAP kinase in a gradual manner., Data show that sustained activation of p38(MAPK) is essential for the death cascade following exposure of Ewing's sarcoma tumor cells to bFGF and provide evidence that activation of p38(MAPK) results in an up-regulation of the death receptor p75(NTR)., p38 is a central component of NK cell ability to directly respond to dsRNA pathogen-associated molecular pattern (PAMP)., NF-kappaB and pp38 mitogen-activated protein kinase have roles in endoplasmic reticulum stress-stimulated expression of cyclooxygenase 2, Apoptosis of neutrophils from patients with active TB is induced by the interaction with the whole M. tuberculosis via Toll-like receptor 2 (TLR2), and involves the p38 mitogen-activated protein kinase (MAPK) pathway, the synergistic induction of IFN-gamma by interleukin-12 and IL-18 in natural killer cells is mediated at least in part by p38-dependent and 3' UTR-mediated stabilization of interferon-gamma mRNA, a specific requirement for p150(Glued)/dynein/functional microtubules in activation of MKK3/6 and p38 MAPKs in vivo., Data show that Exip, but not p38alpha, binds to Toll interacting protein, which is involved in interleukin-1 (IL-1) signaling pathway, and impaired NF-kappaB activity., These findings indicate that signaling via PKCdelta-p38 kinase-linked cascade specifically induces expression of VCAM-1 in lung epithelium in response to TNF-alpha and that this effect is both functionally and clinically significant., low-density shock waves enhance IL-2 expression through a mechanism that involves p38 MAPK activation, MAP kinase kinase3- and 6-dependent activation of the alpha-isoform of p38 MAP kinase is required for the cytoskeletal changes induced by neutrophil adherence and influences subsequent neutrophil migration toward endothelial cell junctions, important for the control of interleukin-6 and IL-8 release by human brain microviascular endoethelial cells during interaction with Neisseria meningitidis, To gain insight into cellular mechanisms that regulate apoptosis, survival and proliferation, we studied the modulation of p38 mitogen-activated protein kinase (MAPK) and the activation state of cdc2 kinase, which regulates progression into mitosis., activation of p38 MAPK and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and TNFR1/TNFa expression, basal PAK6 kinase activity was repressed by a p38 mitogen-activated protein (MAP) kinase antagonist, p38 MAPK plays a critical role in GDF-8's function as a negative regulator of muscle growth, the early and temporary activation of PP2A in neutrophils impaired not only the p38 MAPK-mediated inhibition of caspase 3 but also restored the activity to caspase 3 that had already been phosphorylated and thereby inactivated, LMP1-mediated p38/SAPK2 activation induces expression of the chemokine IP-10 and regulates transcript stability, The expression of tenascin-W is dependent on p38MAPK and JNK signaling pathways in mammary tumors., Changes in extracellular pressure during infection or inflammation regulate macrophage phagocytosis by a FAK-dependent inverse effect on p38 MAPKalpha that might subsequently downregulate ERK., Data suggest that Rit is involved in a novel pathway of neuronal development and regeneration by coupling specific trophic factor signals to sustained activation of the B-Raf/ERK and p38 MAP kinase cascades., We demonstrate that one of the mitogen-activated protein kinases (MAPKs), p38 MAPK, regulates the serotonin transporter (SERT)., NF-kappaB appears crucial in ICAM-1 induction, but p38 activation itself is not sufficient to confer HO-1 expression and may not be involved in HO-1 and ICAM-1 induction in human tumor cells, ANP recruits a signal pathway associated with p38 MAPK, NHE-1 and PLD responsible for ROS production, suggesting a possible role for ANP as novel modulator of ROS generation in HepG2 cells, These results indicate that B lymphocyte stimulator (BLyS)-activated p38 mitogen-activated protein kinase plays an essential role in BLyS-induced activation-induced cytidine deaminase expression and Ig class switch recombination in human B cells., H-Ras-specific activation of Rac-MKK3/6-p38 pathway has a role in invasion and migration of breast epithelial cells, p38alpha and -beta mediate UV-induced, AP-1-mediated, c-Fos phosphorylation, Finally, we conclude that the up-regulation of CCR5 and CXCR4 can at least partially contribute to the down-regulation of transfactor YY1 which is p38 MAPK pathway-dependent and this up-regulation has little relationship with MTB and HIV co-infection., Pharmacological inhibition of oxidative stress diminished the elevated p38, JNK activity and PARP cleavage, and enhanced PD cybrid viability., p38 MAP kinase plays a pivotal role in the signal transduction pathways regulating the number of endothelial progenitor cells ex vivo., IL-1b decreases expression of the ENaC alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway, both p38 and ERK1 are spatially regulated in different uterine regions during pregnancy/labor, MEK6E activates p38 and results in phosphorylation of its downstream substrate, heat shock protein 27, Effect of hibuscus polyphenol extracs in human gastric carcinoma cells is mediated via p53 signaling and p38 MAPK/FasL cascade pathway., p38 mediates EGF receptor activation after oxidant injury; Src activates MMK3, which, in turn, activates p38; and the EGF receptor signaling pathway plays a critical role in renal epithelial cell dedifferentiation, p38 MAPK has a role in the pathway of GC-induced apoptosis of lymphoid cells, transcriptional induction of HO-1 gene expression by AEBSF is mediated via activation of a PKB, p38 MAPK signaling pathway, a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module is regulated by Protein Kinase A gating and then regulates invasion in breast cancer cell lines, Together, our data suggest that inhibition of p38 MAPK may be an attractive target to limit inflammatory responses that are mediated by TNF-alpha., FACL4 is involved in the hepatocellular carcinoma tumorigenesis and both cAMP and p38 MAPK pathways are associated with the regulation of FACL4, ERK2 and p38 have complementary effects in the control of platelet adhesion to collagen in a shear stress-dependent manner, p38 MAPK pathway was found to be involved in liganded estrogen receptor beta repression activity by ErbB2 signaling., STAT3 signaling pathway is involved in IL-6-induced neuroendocrine(NE) differentiation and that p38 MAPK is associated with IL-6-stimulated growth regulation in NSCLC-NE cells., the PI3-kinase/p38(MAPK)/CREB pathway contributes to the EGF activation of NF-IL6beta gene expression, Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner, mast cell chymase activates ERK and p38 probably through G-protein-coupled receptor, and the ERK but not p38 cascade may have a crucial role in chymase-induced migration of eosinophils, Reduction-oxidation regulation ofgamma-glutamylcysteine synthetase expression is mediated by p38 mitogen-activated protein kinase signaling., IL-1beta-induced cPLA2 and COX-2 gene expression is modulated through the p38 MAPK pathway in both neuroglioma and neuroblastoma cells., activation of PKC, p38(MAPK), JNK, ERK1/2, and Nrf2 by oxidized LDL in human smooth muscle cells leads to HO-1 induction, constituting an adaptive response against oxidative injury that can be ameliorated by vitamin C, study shows a new role for p38alpha in contact inhibition and provides a mechanistic basis for the recently proposed tumour suppressive function of this MAPK pathway, contribution of p38 MAPK signaling to the TGF-beta-mediated regulation of the human alpha2(I) collagen gene in normal dermal fibroblasts and constitutive upregulated expression of type I collagen and fibronectin in systemic sclerosis, T-cad overexpression in vascular endothelial cells protects against stress-induced apoptosis through activation of the PI3K/Akt/mTOR survival signal pathway and concomitant suppression of the p38 MAPK proapoptotic pathway, alpha-lipoic acid induces HO-1 expression in THP-1 monocytic cells via Nrf2 and p38, biological responses of OPG and sRANKL synthesis in osteoblasts to the application of cyclic tensile strain are regulated via the p38 MAPK pathway, Data support a role for p38 MAPK in cannabinoid receptor 2-induced apoptosis of human leukaemia cells., determination of whether Rickettsia rickettsii infection of endothelial cells activates p38 and/or c-jun N-terminal, These studies suggest that HCV core protein can lead to enhanced p38- and gC1qR-dependent IL-8 expression., an independent role for p38 MAPK and JNK in LPA-induced IL-8 expression and secretion via NF-kappaB and AP-1 transcription respectively in human bronchial epithelial cells., Importantly, inhibition of p38alpha MAPK blocks the release of vascular endothelial growth factor and suppresses tumor-promoted endothelial cell migration, a key step in angiogenesis., A3 receptor stimulation activates p44/p42 and p38 mitogen-activated protein kinases, which are required for A3-induced increase of HIF-1alpha and Ang-2, the capacity of LDLs to induce fibroblast spreading and accelerate wound closure relies on their ability to stimulate IL-8 secretion in a p38 MAPK-dependent manner, Taken together, these results indicate a novel role for CIN85 in the regulation of cellular stress response via the MAPK pathways., Collectively, our results demonstrate that PGE(2) at physiologically relevant concentrations induces COX-2 expression in human NPE cells via activation of EP(2)- and EP(4) receptors and phosphorylation of p38 and p42/44 MAPKs., The results suggest that oncogenic K-Ras enhances the malignant phenotype and identify the mitogen-activated protein kinase p38 as a target to inhibit oncogenic K-Ras-induced pancreatic tumor cell migration., in pancreatic cancer cells, the p38-mediated phosphorylation of HIF-1alpha contributed to the inhibition of HIF-1alpha and von Hippel-Lindau tumor suppressor protein interaction during ischemia, p38 MAPK and Nrf2 have roles in phenolic acid-induced P-form phenol sulfotransferase expression in human hepatoma HepG2 cells, p38 regulates PPARgamma expression and activity in term human trophoblasts., selectivity pocket compounds prevent MKK6-dependent activation of p38alpha in addition to inhibiting catalysis by activated p38alpha, The signaling pathway for colonocyte apoptosis following toxin A exposure involves p38-dependent activation of p53 and subsequent induction of p21(WAF1/CIP1), resulting in cytochrome c release and caspase-3 activation through Bak induction., activation of p38MAPK is required for the inhibitory effect of LDL on Na+/H+ antiport and thereby for LDL-dependent sensitization in human platelets, activation of the c-Abl-PKCdelta-Rac1-p38 MAPK pathway in response to ionizing radiation signals conformational changes of Bak and Bax, resulting in mitochondrial activation-mediated apoptotic cell death in human non-small cell lung cancer cells, p160 coactivator glucocorticoid receptor-interacting protein 1 (GRIP1) is phosphorylated and potentiated by the p38 MAPK signaling cascade in vitro and in vivo., HCV core expression leads to deregulation of the mitotic checkpoint via a p38/PKR-dependent pathway, In conclusion, increased TGF-beta2 transcription in response to serum stimulation in KFs appears to be mediated by the p38 MAPK pathway., p38 MAPK is a potential therapeutic target, inhibition of which may maintain the cellularity of articular chondrocytes by inhibiting cell death and its amplification signal and by increasing cell proliferation., These results suggest that the p38 kinase, through its ability to control Erk activation levels, acts as a gatekeeper, which prevents inappropriate IL-2 production., Asymmetric dimethylarginine induces apoptosis of endothelial cell via elevation of intracellular oxidant production, which involves p38 MAPK/caspase-3-dependent signaling pathway., the inhibition of p38 MAP kinase might enhance anti-inflammatory tendencies in the MH7A cells, Data suggest that 2-methoxyestradiol 2 inhibits estradiol-stimulated proliferation and induces apoptosis in ovarian carcinoma cells, and that activation of p38 and phosphorylation of Bcl-2 plays a critical role in the mechanism., p38 MAPK may play an important role in Stat-6 phosphorylation and the induction of IL-4, Bax, Bcl-2 & Bcl-xL and a putative role in protecting cells from undergoing apoptosis., S100A8/A9 heterodimer, secreted extracellularly from activated tissue macrophages, may amplify proinflammatory cytokine responses through activation of NF-kappaB and p38 MAPK pathways in rheumatoid arthritis., p38 has emerged as an important regulator of both embryonic development and cancer progression [review], Our data indicate that TGF-beta1 induces endothelial barrier dysfunction involving Smad2-dependent p38 activation, resulting in RhoA activation by possible transcriptional regulation., Determinants that control the specific interactions between TAB1 and MAPK14 are identified., involvement of p38 MAP kinase in the hyaluronan oligosaccharide induction of MMP-13, role for p38 MAP kinase in the regulation of EGFR endocytosis, p38 kinase plays an important role in iron chelator-mediated cell death., p38 plays a key role during small intestinal ischemia reperfusion injury through a proapoptotic action on the tip of villi., ERK1/2, JNK1/2 and p38 mapk pathways are all required for B[a]P-induced G1/S transition, Platelet activating factor signaling requires beta-arrestin-1 recruitment of a p38 MAP kinase signalosome for transduction before neutrophil endosomal scission., two inhibitors of p38 MAPK and protein tyrosine kinase pathways could be used as combined targets for inhibiting matrix metalloproteinase-9 expression in inflamed tissues, p38 MAPK, Acidic pH exposure protects HEMEC through induction of Hsps and activation of MAPK and PI3 kinase pathway., Results show that activation of c-Jun N-terminal protein kinase, ERKs 1 and 2, and p38 MAP kinase is critical for Hs683 glioma cell migration induced by GDNF., TGF-beta1 regulates COX-2 expression in human mesangial cells through the activation of ERK1/2, p38 MAPK, and PI3K., doxorubicin-stimulated phosphorylation of BCL2-antagonist of cell death in cells expressing dominant negative p38 MAPK was impeded by the inhibition of PI3-kinase, MAPKAP kinase-2 phosphorylates CDC25B on multiple sites including S169, S323, S353 and S375, while p38SAPK phosphorylates CDC25B on S249., High glucose accelerates the onset of endothelial progenitor cell senescence leading to the impairment of proliferative activity, which might be related to the phosphorylation of p38 MAPK., These studies establish p38 MAP kinase-mediated activation of ATF-2 as a significant mechanism in amylin-evoked beta-cell death, which may serve as a target for pharmaceutical intervention and effective suppression of beta-cell failure in type-2 diabetes., Our results indicate that CD23 expression in these human intestinal epithelial cells is mediated through the p38 MAPK pathway., E2F and Wip1 are modulators of E2F1-induced apoptosis involving p38 MAP kinase, DUSP26 effectively dephosphorylates p38 and has a little effect on extracellular signal-regulated kinase in anaplastic thyroid cancer., These results suggest that p38 affects the phosphorylation of Smad2 and Smad3 differentially during TGF-beta signaling in human dental pulp cells and ERK1/2 might be involved in the process., This study is the first to demonstrate that H2O2 induces a Rac1/JNK1/p38 signaling cascade, and that JNK and p38 activation is important for H2O2-induced apoptosis as well as apoptosis-inducing factor/Bax translocation of retinal pigment epithelial cells., All trans-retinoic acidinduces apoptosis in Barrett's epithelial cells and sensitizes them to apoptosis induced by UV-B irradiation via activation of p38., Icreased nitration of phospho-p38 mitogen-activated protein kinase occurs in the pre-eclamptic placenta. Its catalytic activity & the concentration of phospho-p38 MAPK was also reduced., p38 MAPK and JNK pathways play an important role in VEGF secretion from malignant glioma cells under normoxic conditions., p38 MAPK and NF-kappaB were crucial for the hydrolase-modified LDL-induced IL-8 secretion from the macrophages., These data suggest that M. bovis BCG induces human beta defensin-2 mRNA expression in A549 lung epithelial cells at least in part mediated through intracellular calcium flux as well as activation of p38MAPK, These results indicate that 2ME-induced barrier disruption is governed by microtubule depolymerization and p38- and ROCK-dependent mechanisms., p38alpha plays an important role in extravasation of tumor cells, possibly through regulating the formation of tumor-platelet aggregates and their interaction with the endothelium involved in a step of hematogenous metastasis, results suggest that p38 MAP kinase is involved not only in activating NADPH oxidase stimulated by fMLP but also in determining the extent of its activity., accumulation of C(16)-ceramide in mitochondria formed from the protein kinase C-dependent salvage pathway results at least in part from the action of longevity-assurance homologue 5, and the generated ceramide modulates the p38 cascade via PP1, hSef isoforms can control signal specificity and subsequent cell fate by utilizing different mechanisms to modulate RTK signaling, SOX9 mRNA regulation in human articular chondrocytes involves p38 MAPK activation and mRNA stabilization, Sin1 binds directly to both ATF-2 and p38., Phosphorylation of p38 by GRK2 at the docking groove unveils a novel mechanism for inactivating p38MAPK., high-resolution crystal structures of the intrinsically active p38alpha mutants reveal that local alterations in the L16 loop region promote kinase activation, p38 MAPK as an upstream regulator of nSMase2, hyperactive variants of p38alpha induce, whereas hyperactive variants of p38gamma suppress, activating protein 1-mediated transcription, epidermal growth factor (EGF)-mediated induction of transforming growth factor-beta receptor type II expression may participate in a synergistic interplay between EGF and transforming growth factor-beta signaling pathway, These findings are consistent with the hypothesis that cytokine-induced autophosphorylation of P38 MAPK in primary granulocytes depends on the interaction with TAB1., Further characterization of enzyme kinetics showed the binding mode of MT4 was competitive with the ATP substrate-binding site of p38alpha MAPK., role for p38 MAPK and actin but not protein kinase C zeta in generating the neutrophil respiratory burst to beta-glucan, Our results confirm that ultrasound induces apoptosis via a pathway that involves Bak, Bcl-2, and caspases, but not ROS., possibility that the IL-6 mediated androgen-independent proliferation of PC-3 and DU145 prostate cancer cells is regulated at least partly via SAPKs signaling pathway especially through p38MAPK activation.gh p38MAPK activation, Study demonstrates that BMP-2 promotes chondrogenesis by activating p38 mitogen-activated protein kinase, which downregulates Wnt-7a/b-catenin signaling responsible for proteasomal degradation of Sox9., p38 MAPK/NF-kappaB/cyclin D1 signaling pathway might participate in the oncogenesis of extramammary Paget's disease, Results indicate that stimulation of heme oxygenase-1 expression by hypericin-PDT is a cytoprotective mechanism governed by the p38(MAPK) and PI3K pathways., The expression of p-p38 and uPA was negatively correlated to prognosis of breast cancer., Data show that HCMV could activate p38MAPK pathway and trigger apoptosis and interfere cell cycle in U251 cells., p38 MAPkinase mediates palmitate-induced apoptosis and may participate in coronary endothelial injury in diabetes., a new activating mutation site in p38alpha is identified., a cross-talk of cell-cycle regulation and p38-dependent signal transduction is required for the suppressor function of iTregs., Binding of MAP-kinase-activated kinase 2 (MK2), Mxi2 is a key spatial regulator for ERK1/2 and we disclose an unprecedented stimulus-independent mechanism for ERK nuclear import., GATA-3 nuclear translocation is dependent on its phosphorylation on serine residues by p38 MAPK, Epac1 and Epac2 induce a potent activation of the Ca2+-sensitive big K+ channel, slight membrane hyperpolarization, and increased after-hyperpolarization in cultured cerebellar granule cells. These effects involve activation of Rap and p38 MAPK., Ad-PGIS gene transfer reduced PPAR delta expression and inhibited neointimal formation after balloon injury in accordance with the reduction in the phosphorylation of p38 MAPK, These results strongly suggest that hypoxia-induced apoptosis is regulated through signal transduction in which inactivation of ERK1/2 leads to activation of p38, which then triggers caspase cascade as an execution mechanism of apoptosis., These results suggest that in human tracheal smooth muscle cells, activation of p42/p44 MAPK, p38, and JNK pathways, at least in part, mediated through NF-kappaB, is essential for lipopolysaccharide-induced VCAM-1 gene expression., These lines of evidence suggested that a Gq-coupled receptor activates specifically p38 MAPK through lipid rafts and Src kinase activation, in which flotillins positively modulate the Gq signaling., Intermittent hypoxia/reoxygenation activates NF-kappaB in an IKK-dependent manner signaled at least in part via activation of p38 MAPK., NHERF1 overexpression enhances the invasive phenotype in breast cancer cells, both alone and in synergy with exposure to the tumor microenvironment, via the coordination of PKA-gated RhoA/p38 signaling., results indicate that p38alpha and p38delta specifically promote the malignant phenotype of squamous cell carcinoma cells, These data demonstrate that IGF-I induces COX-2 expression in human ovarian cancer cells, which is mediated by three parallel signaling cascades--PI3K, MAPK, and PKC pathways that differentially regulate COX-2 expression., These results suggest that TGFbeta1-induced FN production in HKC cells is p38 MAP kinase dependent and Smad independent. Targeting p38 MAP kinase may be of therapeutic value in renal fibrosis., p38 signaling pathway triggering cyclin B1 proteolysis after arsenite exposure may play an important role in connecting G(2) arrest with apoptosis or genome instability., Mitogen-activated protein kinase (MAPK) kinase 3 (MKK3) is a key activator of p38 MAPK in glioma; MKK3 activation is strongly correlated with p38 activation in vitro and in vivo., Cytokine activation of MAPK14 and apoptosis is opposed by ACTN4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3., Finally, p38 but not extracellular signal-regulated protein kinase activation was required for TRPV1-mediated CPS-induced apoptosis of glioma cells, Cytokine-induced production of OPG may protect beta cells from further damage, an effect mediated through inhibition of p38 map kinase phosphorylation., p38 alpha MAP kinase is one of the critical downstream signals for development of cardiomyopathy following chronic beta 2-adrenergic receptor stimulation in transgenic mice., The regulation of three major mitogen-activated protein kinases phosphorylation, ERKp44/p42, p38, and JNK, was determined. The influence of specific mitogen-activated protein kinase inhibitors on IL-1 beta protein levels during beta-endorphin stimulation., These results demonstrate that 9-cis-Retinoic acid transduces the signal through p38 MAPK and ERK1/2 for CCR1 and CCR2 up-regulation., inactivation of p38alpha leads to an immature and hyperproliferative lung epithelium that is highly sensitized to K-Ras induced tumorigenesis, p38 MAPK is involved in IGFBP-6-induced IGF-independent rhabdomyosarcoma cell migration, Overall, our data suggest a finely tuned control exerted by rapid signals on different cellular molecular events important for the protective effects of E2 against colon cancer growth., The results of the present study suggest that lysophosphatidic acid (LPA), the receptor LPA(1), ERK2 and p38alpha are important regulators for prostate cancer cell invasion and thus could play a significant role in the development of metastasis., These results point to a pivotal role for p38 MAPK pathway during GTP-mediated erythroid differentiation of K562 cells., Gbetagamma mediates UVB-induced human keratinocyte apoptosis by augmenting the ectodomain shedding of HB-EGF, which sequentially activates EGFR and p38, p38 regulates the timing of mitotic entry via modulation of Cdc25B activity under normal nonstress conditions, Neurotensin induces a striking increase in Hsp27 phosphorylation on Ser-82 in PANC-1 cells through convergent p38 MAPK, PKD, and PKD2 signaling., The results show that Hcy activated both ERK(1/2)/p38MAPK pathway and NF-kappaB-DNA-binding activity., GCK is required for JNK and, unexpectedly, p38 activation by three bacterial PAMPs, lipopolysaccharide, peptidoglycan, and flagellin, These findings suggest a novel model for the regulation of caspase-8 during Mn(2+)-induced apoptosis based on the sequential activation of p38 MAPK, MSK1, caspase-8 and mitochondria, respectively., the activity of caspase-1 is increased in psoriatic skin and IL-18 secretion is regulated by a p38 MAPK/caspase-1-dependent mechanism, These data together uncovers a new signaling pathway regulating APE/Ref-1 nuclear translocation involving CD40-crosslinking, TRAF2 and p38., END and ENK are contained in primary granules of PMN, and that CXCR1/2 ligands induce p38-dependent translocation and release of these opioid peptides to inhibit inflammatory pain, the p38(MAPK) signaling pathway is required for optimal LPA-dependent uPA secretion from ovarian cancer cells, In the absence of EGF, p38MAPK-activated AKT is necessary for HER-2 overexpressing human breast cancer cells to survive and to form colonies in soft agar., gp120, in the presence of IFN-gamma, can cause dysfunction of the blood-brain barrier endothelium via MAPK pathways, EGFR activation in malignant gliomas can transcriptionally activate COX-2 expression in a process that requires p38-MAPK and Sp1/Sp3, Connexin43 expression can be influenced by Ang II and IGF-1 through ERK and p38 pathways and may contribute to the pathogenesis of vein graft disease following coronary artery bypass grafting., These data show that angiotensin II attenuates Ca2+ uptake predominantly into mitochondria that do not colocalize with endoplasmic reticulum, by a mechanism involving p38 MAPK and a novel-type PKC., IL-17 is a potent inducer of CRP expression via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation., PF4-stimulated immediate monocyte functions (oxygen radical formation) are regulated by p38 MAPK, Syk, and PI3K, whereas delayed functions (survival and cytokine expression) are controlled by Erk and JNK., Results indicate a new pathway that includes induction of p38 MAPK by PKC and results in specific phosphorylation of c-Jun in T-cells., Thimerosal caused Ca2+-independent apoptosis of gastric cancer cells via phosphorylation of p38 MAPK and caspase-3 activation., Upregulation of costimulation-induced IL-25 receptors and release of cytokines and chemokines from IL-25 treated costimulated Th cells were differentially regulated by intracellular JNK, p38 MAPK and NF-kappaB activity., The activation of p38 was dependent on Axin and was required for the enhancement of mesenchymal stem cells differentiation by Wnt-4., Mapk14 antagonizes Mapk12 activity through c-jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response., p38/CREB phosphorylation and COX-2 expression are inhibited by olive oil polyphenols, BMP6 induced cell cycle arrest in estrogen-insensitive breast cancer cells. BMP6 inhibits stress-induced apoptosis via both Smad and p38 signal pathways., These observations indicate regulation of the early secretory pathway by p38 MAPK., p38 MAPK activation in response to cisplatin does not require the tyrosine kinase activity of c-Abl, These results suggest the involvement of negative regulation of p38 in contact-inhibited growth control., IL-17 induces MMP-1 in human cardiac fibroblasts directly via p38 MAPK- and ERK-dependent AP-1, NF-kappaB, and C/EBP-beta activation., SB203580, a specific p38 MAPK inhibitor, completely blocked Toll-like receptors ligand mediated IL-12p70 secretion, P38MAP kinase and HSP27 are phosphorylated in pemphigus skin, bFGF does not directly act on p38 nor on the mRNA expression levels of activin receptors but inhibit activin A activation of p38 upstream of p38 in K562 cells., p38 mitogen-activated protein kinase pathway activation appears to be involved in the pathogenesis of chronic obstructive pulmonary disease, Shiga toxin activates a signaling cascade involving cross talk between Ca(2+) and p38, to regulate its trafficking to the Golgi apparatus., SHED cells transmitted BMP signals through both the SMAD and p38 mitogen-activated protein kinase (MAPK) pathways and responded to BMP4 treatment by inducing BMP responsive genes, Data demonstrate that si-RNA knock down of p38alpha completely diminished high [Ca(2+)](e)-mediated vitamin D receptor induction., This study reports a rapid, economical and single step purification process for the overproduction of GST tagged p38alpha MAPK. The purified protein was found to be biologically suitable for phosphorylation by upstream kinases & was catalytically active., a novel regulatory role of p38 during neuroinflammation where this MAP kinase controls acetylation of NF-kappaB p65 by regulating acetyltransferase activity of coactivator p300., Induction of cathepsins is associated with the activation of protein p38 MAP kinase., the distal C162S mutation has an effect on the energetics of drug binding to p38alpha MAP kinase, These data indicate the role of p38 in the control of systemic and renal hemodynamics both in normal and in diabetic rats., these results indicate that activation of the ASK1/p38 MAPK/p47phox cascade plays a central role in PPD/TLR2-induced ROS generation and suggests the existence of a 'ROS/ASK1' inflammatory amplification feedback loop in monocytes/macrophages., Phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase are protein kinases that regulate the prosurvival effect of glucocorticoids on human neutrophils., Cx43 hyperphosphorylation induced by UVA is, at least in part, mediated through mitogen-activated protein kinase (MAPK) activation as Ser279 and Ser282 sites, two downstream direct targets of p38 MAPK were found to be phosphorylated after UVA treatment., Data suggest that the p38 MAP kinase and NF-kappaB signaling pathways play an important role in regulation of IL-23p19 expression on human microglia, and are thus potential therapeutic targets in the treatment of MS., Chloroquine affects the activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK)., UVB irradiation leads to an activated p38 MAPK that is regulated in an IGF-1R-dependent manner, leading to NF-kappaB p50, The production of GRO-alpha, IL-6 and IL-8 was shown to account for the ability of the HeLa cell culture medium to stimulate the migration of monocytes/macrophages, suggesting a key role for p38 MAPK and ERK1/ERK2., The results show that LPS and TNF-alpha induction of Stx2 sensitivity in HUVEC is mediated through a pathway that includes p38 MAPK., These results clearly indicate that CCDC134 is a novel member of the secretory family and down-regulates the Raf-1/MEK/ERK and JNK/ SAPK pathways., Human herpesvirus 6Binduces p53 Ser392 phosphorylation by an atypical pathway independent of casein kinase 2 protein and p38 kinases., p38-regulated transcription factor activity and subsequent down-stream regulation of stromal-derived cytokines may result in a functionally defective stroma less capable of supporting normal hematopoiesis, in patients with rheumatic heart disease and heart failure p38MAPK activity was elevated in class IV patients compared to those in classes II and III, AEA is able to decrease differentiating gene expression by increasing DNA methylation in human keratinocytes, through a p38, and to a lesser extent p42/44, mitogen-activated protein kinase-dependent pathway triggered by CB1R., Infants with allergic mothers displayed markedly reduced CD14(+) monocyte p38-MAPK phosphorylation after LPS (P<0.05) and peptidoglycan (P<0.01) challenge., ROS-mediated activation of the ASK1-p38 MAPK pathway downstream of P2X(7) receptor is required for ATP-induced apoptosis in macrophages., adenosine-uridine-rich elements-containing mRNA is over-represented among transcripts up-regulated by nitric oxide, an activator of p38 MAPK., TGF-beta mediates its effects on proteoglycan synthesis in VSMCs via the ALK5/Smad2/3 phosphorylation pathway as well as via the p38 MAP kinase signaling cascade., Data demonstrate increased expression of the p38-NF-kappaB axis elements and COX-2 in disintegrated fibrocartilage, suggesting a role of these molecules in the pathobiochemistry of MD and consequential rupture., The p38MAPK pathway is related to paclitaxel resistance of ovarian carcinoma., Inhibition of p38 MAPK in cytokine-activated disc cells blunts production of factors associated with inflammation, pain, and disc matrix catabolism., The p38 pathway induces the expression of extracellular matrix and proliferation-associated genes, while suppressing microtubule-associated genes., These results demonstrate that interruption of TNF-alpha-induced signaling pathways in human endometriotic epithelial cells results in decreased expression and secretion of biomarkers for inflammation., activator protein-1 (AP-1) was activated through phosphorylation of cJun and cFos, induced by JNK and p38, respectively., pH-dependent increase in CXCL8 mRNA is due to activation of ERK and p38 pathways, Alexander disease mutant GFAP accumulation stimulates autophagy, in a manner regulated by p38 MAPK and mTOR signaling pathways., EGF signals via p38 MAPK to increase phosphorylation of BADser112 and thereby limit trophoblast apoptosis., both constitutive and sIgM-induced phosphorylation of p38 and JNK is inhibited by LAIR-1 through an ITIM-dependent signal, hNUDC induced a sustained activation of the extracellular signal-regulated protein kinases-1 and -2 (ERK1/2) as well as p38 mitogen-activated kinase (p38 MAPK) pathways, induction of TNF, IL-1beta, and IL-6 by IL-32 is mediated by p38-MAPK, p38 MAP kinase down-regulates extracellular signal-regulated kinase via activation of MKP-3 in human monocytes exposed to asbestos to enhance TNF-alpha gene expression., analysis of TGF-beta1-independent changes in protein neosynthesis, p38alphaMAPK, and cdc42 in hydrogen peroxide-induced senescence-like morphogenesis, results demonstrate that TGFbeta1 induces alphavbeta3 integrin expression via a beta3 integrin-, c-Src-, and p38 MAPK-dependent pathway, p38 and phospho-p38 MAP kinase were not detected in invasive trophoblasts in preeclampsia cases or controls., activation of p38 isoforms by hypertonicity does not contribute to activation of TonEBP/OREBP because of opposing effects of p38alpha and p38delta., increased expression of ERK1 and activated p38 can predict poor human sperm quality, Structure of p38 alpha in a complex with SB203580 was studied., There is the possibility to inhibit p38alpha in colorectal cancer to arrest tumor progression and induce autophagic cell death., In conclusion, the ERK1/2, but not p38 MAPK pathway is activated by apelin-13 through coupling of human APJ to Gi2-protein, which contributes to cellular responses., These data demonstrate the role of Cx43 in the proliferation and migration of human saphenous vein smooth muscle cells and angiotensin II-induced Cx43 expression via mitogen-activated protein kinases (MAPK)-AP-1 signaling pathway., p38alpha MAPK has a critical role in the regulated translocation of exogenous FGF1 into the cytosol/nucleus, there is a functional Sp1-binding element in the t-PA promoter controlling quercetin induction via the p38 MAPK pathway, As(2)O(3) induced a marked activation of NADPH oxidase in human macrophages, likely through stimulation of a Rho-kinase/p38-kinase pathway, IL-27 activates monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38, Phosphorylation of caveolin 1 during treatment with H(2)O(2) is dependent on p38alpha mitogen-activated protein kinase., p38 mitogen-activated protein kinase (MAPK) also inactivates GSK3beta by direct phosphorylation at its C terminus, and this inactivation can lead to an accumulation of beta-catenin, phosphorylated heat shock protein 27 up-regulated the levels of p38 mitogen-activated protein kinase and mitogen-activated protein kinase phosphatase-1, an inhibitory protein of extracellular signal-regulated kinase, activation of p38 MAPK plays an important role in LPS-induced melanogenesis, ATO-induced activation of Chk2/p53 and p38 MAPK/p53 apoptotic pathways can be enhanced by siRNA-mediated suppression of Wip1 expression, further indicating that ATO inhibits Wip1 phosphatase in vivo, We demonstrate a role for PI3-K, p42/44 MAPK and p38 MAPK in the stimulation of cytotrophoblast cell motility by EGF., Suppression of p38-stress kinase sensitizes quiescent leukemic cells to anti-mitotic drugs by inducing proliferative responses in them., inhibition of JNK and p38 activation interrupts CD40 induced endothelial cell activation and apoptosis, downstream signaling pathways that govern the production of IL-8 include NF-kappaB and p38 MAPK in retinal pigment epithelial cells, Data describe the role of PKC-delta and p38 MAP kinase in HIV-1 Tat protein-induced IL-10 production by an alternative TNF-alpha-independent pathway in monocytes., The existence of a functional binding site for the tumor suppressor p53 near the proximal CCAAT box and the fact that the basal expression of annexin A1 in human colon adenocarcinoma cells is driven by p53 at the transcriptional level, is shown., These results suggest that, in SupT1-based cell lines, p38alpha, p38gamma and p38delta, but not p38beta, are implicated in both HIV-1 induced replication and apoptosis in infected and uninfected bystander cells., Inhibition of ERK1/2 and activation of p38 are involved in diallyl disulfide induced apoptosis of leukemia HL-60 cells., Data demonstrate that Vibrio vulnificus induces death of Jurkat T-cells via reactive oxygen species-dependent activation of p38 MAPK, and that NADPH oxidase plays a major role in ROS generation in V. vulnificus-exposed cells., 1) PAK plays a required role in hyperosmotic signaling through the PI3K/pTEN/Cdc42/PP2Calpha/p38 pathway, and 2) PAK and PP2Calpha modulate the effects of this pathway on focal adhesion dynamics., IL-8 and p53 protein expression is regulated through inverse activation of the p38 MAPK and the JNK pathways and the NF-kappaB p65 expression, NF-kappaB, but not p38, is critical for TNF-alpha-induced expression of ICAM-1, VCAM-1 and E-selectin, the ATR-dependent activation of the p38 MAP kinase is a major signaling pathway that induces apoptotic cell death after depletion of Cdc7 in cancer cells, SARS virus 3a protein modulates the mitochondrial death pathway via activation of p38 MAP kinase., study demonstrates that Chk1 inhibition results in the activating phosphorylation of p38 MAPK; results underscore the role of p38 MAPK as a pro-apoptotic kinase in the p53-dependant pathway for the therapeutic elimination of polyploidy cells, Aspirin induces gastric epithelial barrier dysfunction by activating p38 MAPK via claudin-7., P38 is a critical mediator of bacterial lipoprotein induced TNF-alpha release and NFkappaB activation, whereas PKC is only partially responsible for its response., analysis of the protein kinase A-independent, beta-arrestin-1-dependent signaling pathway for p38 mitogen-activated protein kinase activation by beta2-adrenergic receptors, Histamine-induced Egr-1 expression is dependent on the activation of the H1 receptor, and rapidly and transiently activates PKCdelta, ERK1/2, p38 kinase, and JNK prior to Egr-1 induction., Activations of p38 MAPK and JNK is associated with enhanced cervical cancer cell killing by the combination of arsenic trioxide and ionizing radiation, germinating but not resting conidia of A. fumigatus results in interleukin (IL)-8 synthesis that is controlled by phosphatidylinositol 3-kinase, p38 MAPK, and ERK1/2. MyD88 pathway is activated by A. fumigatus and leads to NF-kappaB activation, 15d-PGJ(2) induces vascular endothelial cell apoptosis through the signaling of JNK and p38 MAPK-mediated p53 activation both in vitro and in vivo, whether MAP kinase phosphatase (MKP)-1, a negative regulator of p38 and JNK, mediates the antiinflammatory effects of shear stress., These results show that a protein moiety of BmpA can induce cytokine responses in synovial cells via activation of the NF-kappaB and p38 MAP kinase pathways and thus, could potentially contribute to the genesis of Lyme arthritis., Antigen-induced p38 MAPK phosphorylation in human basophils essentially contributes to CD63 upregulation, The dimerization and the slow internalization of the receptor accompanied by the delayed phosphorylation of tyrosine 1068 and its degradation by the proteasome, is reported., NS5A protein down-regulates the expression of spindle gene Aspm through PKR-p38 signaling pathway, LDLs stimulate p38 MAPKs and wound healing through SR-BI independently of Ras and PI3 kinase, combination IL-2/IL-4 inhibits GCRalpha nuclear translocation in human T cells, and this effect is reversed by IFN-gamma via inhibition of p38 MAPK activation., p38 MAPK activation is an important initiating event in Nef-mediated PD-1 expression in HIV-1-infected cells., p38 MAPK regulates chromatin remodeling as well as DDB2 degradation for facilitating NER factor assembly, p28GANK knockdown-derived reactive oxygen species induces apoptosis through mitochondrial dysfunction mediated by p38, alpha6beta4 integrin-FAK-p38MAPK pathway is invloved in modulation of LDH expression., Report concluded that TLR-4 might induce HO-1 messenger RNA expression, which is probably involved in p38MAPK activation in the development of the lung dysfunction after hemorrhagic shock and resuscitation., Assess the role of stress signalling via p38 MAP kinase in the premature senescence of ataxia telangiectasia and Werner syndrome fibroblasts., Stimulation of ovarian cancer cell growth appears not to involve the activation of the mitogen-activated protein kinases ERK-1 and p38., These results indicate that TGF-beta activates JNK and p38 through a mechanism similar to that operating in the interleukin-1beta/Toll-like receptor pathway., HMGB1 induced the activation of p38MAPK, ERK1/2 and Akt., p38 kinase which was activated during p53-induced senescence was not observed in vitamin C-treated EJ cells, the myelosuppressive cytokines TNFalpha and IL-1beta are secreted by bone marrow (BM) cells in a p38 MAPK-dependent manner, HPV16 E7-dependent transformation activates NHE1 through a PKA-RhoA-induced inhibition of p38alpha., p38 MAPK is the key signal molecule in the inflammatory reaction induced by Haemophilus influenzae., a critical role for the Pyk2 mediated pathway involving p38 MAP kinase and NF-kappaB in LPS-induced MCP-1 production in human microvascular endothelial cells., Desipramine-induced Ca-independent apoptosis in Mg63 human osteosarcoma cells, Results suggest that p38 mitogen-activated protein kinase in leukemic cells promotes withaferin A-induced apoptosis., Polygonatum cyrtonema lectin induces apoptosis and autophagy via a mitochondrial-mediated ROS-p38-p53 pathway, the action of 1,25(OH)(2)D(3) on colon carcinoma cells depends on the dual action of VDR as a transcription factor and a nongenomic activator of RhoA-ROCK and p38MAPK-MSK1., as a mediator of SF- and Src-stimulated NF-kappaB activity. Finally, the Src/Rac1/MKK3/6/p38 and Src/TAK1/NF-kappaB-inducing kinase pathways exhibited cross-talk at the level of MKK3., Using chemical inhibitors, the authors show that the ICP27-mediated activation of p38 signaling is responsible for the observed induction of apoptosis in the induced cell lines., the presence of melittin, TRAIL-induced apoptosis is significantly increased in TRAIL-resistant HCC cells, which may be attributed to melittin-induced TAK1-JNK/p38 activation and melittin-mediated inhibition of IkappaBalpha kinase-NFkappaB., the c-Src-Rac1-p38 MAPK pathway is required for activation of Akt in response to radiation and plays a cytoprotective role against radiation in human cancer cells, Involvement of p38 MAPK in the TNF-alpha-mediated 11beta-HSD1 regulation; TNF-alpha stimulates enzyme activity in vivo., activation of the p38-MAPK pathway might be responsible for the modulation of P-glycoprotein-mediated and P-glycoprotein-unmediated multidrug resistance in the SGC7901/VCR cell line, Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle., p38 MAP kinase and IRF3 separately and predominantly contribute to avian influenza A virus H5N1-mediated induction of interferon (IFN)-beta, IFN-lambda 1 and monocyte chemoattractant protein-1 but only partly control tumor necrosis factor-alpha induction., Inhibition of cytokine response by IL-25 occurred via a p38 Map kinase-driven Socs-3-dependent mechanism, p38 MAP kinase controls EGF receptor downregulation via phosphorylation at Ser1046/1047., level of furin expression in Colo16 cells correlated to changes in pp38 levels in the cells following exposure to UV radiation, During long-term folate stress, p38 is the primary determinant of CCL2 transcription, crucial implication of PKC-delta, PKC-zeta, ERK-1/2, and p38 in human blood eosinophil migration through extracellular matrix components, p38 MAPK is critical at the source of microparticle formation, but not the target cell response to endothelial microparticles, C. albicans-native phospholipomannan may contribute to the inflammatory responses of cutaneous candidiasis in the TLR2-NF-kappaB and p38MAPK signalling pathway dependent manner., p38 is active when only the Thr180 residue is phosphorylated., the suppression of CX3CL1 production by WIN55,212-2 involves inhibition of signaling via p38 MAPK., IFNgamma-stimulated mast cells induce productions of inflammatory cytokines through PKC/p38/NF-kappaB and AP-1 pathways, not through classical JAK/STAT1 pathway, in mast cells, Collagen XVII participates in keratinocyte adhesion to collagen IV, and in p38MAPK-dependent migration and cell signaling., p38alpha and p38gamma are essential components of the signaling pathway that regulates the tumor-suppressing senescence response, upregulation of Txnip and subsequent impairment of thioredoxin antioxidative system through p38 MAPK and FOXO1 may represent a novel mechanism for glucose-induced increase in intracellular ROS., p38/XBP-1 signaling negatively regulated ERp29 expression in BT549 breast cancer cells, cell Ca2(+) plays a fundamental role in wound healing even without PL, p38 and ERK1/2 are essential for PL effects but are also activated by wounding, MAPK p38 induces Bcl-6 transcription, but increased protein expression occurs only when the strong pathways repressing Bcl-6 are not activated., the earlier peak of p38MAPK activation is part of the mechanism leading to acantholysis, whereas the later peak of p38MAPK and apoptosis may not be essential for acantholysis., Overexpression of Nox4 induces p38 MAPK phosphorylation, while Nox4 down-regulation by shRNA has no effect on p38 MAPK., p38-MAPK signaling pathway is involved in the bruceine-D-induced apoptosis in pancreatic cancer cells., Cdc25A degradation depended on Ser75-Cdc25A phosphorylation caused by p38MAPK and Chk2., Upregulation of COX-2 expression suggested its role as a mediator in chronic rhinosinusitis. ERK and p38MAPK pathways were involved in signaling COX-2 through NF-kappaB pathway., These results strongly suggest a dual regulatory role for C3G in chronic myeloid leukemia cells, modulating both apoptosis and survival via Rap-dependent and independent mechanisms., Mitogen-activated protein kinase 14 blockade induces FoxO nuclear accumulation, its binding to promoters and the expression of target genes., An Ask1-MKK4-p38MAPK/JNK pathway reflects adipocyte stress associated with adipose tissue inflammation, linking visceral adiposity to whole-body insulin resistance in obesity., activated following exposure of immature MoDCs to OK-432, a streptococcal preparation, confluent p38alpha-deficient cells fail to downregulate Spry2, providing them in turn with sustained EGFR signaling that facilitates cell overgrowth and oncogenic transformation, These findings suggest that ouabain downregulates mCD14 expression on monocytes through EGFR transactivation and p38 MAPK activation., The adenylyl cyclase-cAMP system has an inhibitory role in IFN-gamma plus TNF-alpha-stimulated production of TARC and MDC in HaCaT keratinocytes by inhibiting NF-kappaB activation through p38 MAPK pathway., USF-1 specificity is directed via p38-mediated phosphorylation-dependent acetylation, p38 MAPK is a major regulator of MafA protein stability under oxidative stress, Data show that in the liver of alveolar echinococcosis patients, ERK 1/2 and p38 MAPK were activated and PCNA expression was increased, and that upon exposure to vesicle fluid, c-Jun N-terminal kinase (JNK) was also activated in hepatocytes in vitro., expression levels and subcellular distribution of hnRNP A1 are regulated in a p38 MAPK-dependent manner, siRNA to uPAR significantly inhibited cell proliferation and migration and stimulated apoptosis, to a greater extent than uPA siRNA., Results show correlation between induction of p53, reactive oxygen species and phospho-p38, whereas p38(MAPK) inhibition rescued cell growth markedly., Concluded that ROS-mediated p38 MAPK activation plays a vital role in dihydrotanshinone-induced apoptosis in HepG2 cells., LDM suppresses MM cell growth through the activation of p38 MAPK and JNK, with the potential to be developed as a chemotherapeutic agent for MM., Oxidative stress activates ADAM17/TACE and induces its target receptor shedding in platelets in a p38-dependent fashion., Overexpression of p38 MAPK protected apoptosis by co-treatment with genistein and TRAIL, suggesting that it acts as a regulator of apoptosis in human hepatocellular carcinoma cells., The authors present the crystal structure of human p38alpha MAP kinase, which has a lead compound bound both in the active site and in the lipid-binding site of the C-terminal cap., These data suggest that n-6 dietary fatty acids stimulate a set of interactions that regulates cell adhesion through RhoA and ROCK II via a p38 MAPK-dependent association of HSP27 and p115RhoGEF., Vascular cell adhesion molecule-1 expression in human intestinal microvascular endothelial cells is regulated by PI 3-kinase/Akt/p38 MAPK/NF-kappaB, PM induces ROS generation in human lung endothelium, resulting in oxidative stress-mediated EC barrier disruption via p38 MAPK- and HSP27-dependent pathways., Data show that inhibition of p38 MAPK and its phosphorylation of HuR impairs p21(Cip1) accumulation and, as a result, the ability of cells to arrest in G(1) in response to gamma radiation., The Ca(2+)-sensitive component to MAO-A activity is present in human brain and in vitro studies link it to the p38(MAPK) pathway., Nox4 silencing decreased PAI-1 synthesis in human cultured endothelial cells demonstrating the involvement of the constitutively active Nox4-containing NADPH oxidase in ROS-mediated PAI-1 transcription via p38 MAPK pathways, Cilostazol protects endothelial cells against lipopolysaccharide-induced apoptosis through ERK1/2- and P38 MAPK-dependent pathways., Pregnancies with placental dysfunction and hypertensive complications are characterized by a significantly decreased expression of MAPK p38alpha., Data elucidate a novel signaling network that leads to increased IL-8 production through p38 mitogen-activated protein kinase-dependent phosphatidylinositol 3-kinase activation in response to proteasome inactivation., Advanced glycation end products induce calcification of vascular smooth muscle cells through RAGE/p38 MAPK., Results identify components of the regulatory mechanisms driving p38-induced cancer cell quiescence., Adiponectin-stimulated CXCL8 release in primary human hepatocytes is regulated by ERK1/ERK2, p38 MAPK, NF-kappaB, and STAT3 signaling pathways., the phospho-p38 mitogen-activated protein kinase as a novel interacting protein of DAPK in tumor necrosis factor-alpha-induced apoptosis., AT-III directly acts on platelets and suppresses ADP-induced platelet granule secretion due to inhibiting HSP27 phosphorylation via p44/p42 MAPK and p38 MAPK., Data show that sorafenib inhibited the raf/ MEK/ERK signal pathway, and downregulated cyclin D1 and Rb levels., Importance of a novel JNK/p38-Cdc25B axis for a nongenotoxic stress-induced cell cycle checkpoint., Demonstration of SMN protein regulation through the p38 pathway and the role of HuR in this modulation may help in the identification and characterization of p38 pathway activators as potential therapeutic compounds for the treatment of SMA., Results demonstrated that the growth inhibition of HEC1A cells by GnRH-I or GnRH-II is involved in the activation of integrin-FAK and ERK1/2 and p38 MAPK pathways., Data show that BME induces the activation of c-Jun N-terminal kinases, p38 mitogen-activated protein kinases and extracellular signal-regulated kinases (ERK)1/2., Data show that p53-independent curcumin-induced apoptosis in ovarian carcinoma cells involves p38 MAPK activation, ablation of Akt signaling, and reduced expression of the antiapoptotic proteins Bcl-2 and survivin., cross talk occurs between tumor necrosis factor receptor and TGF-alpha/epidermal growth factor receptor in human bone marrow mesenchymal stem cells is mediated via activation of p38, Suppression of p38 MAPK sensitized T cells to Fas-mediated apoptosis and increased caspase-8 and caspase-3 cleavage, Specific isoforms of p38 and their sub-cellular localization may have different roles in modulating ischemic injury., Results suggest that simple but robust rules encoded in the p38 MAP kinse structure play a dominant role in predefining the mechanisms of ligand binding, which may be advantageously exploited in designing inhibitors., inhibition of p38(MAPK) significantly reduced stromal-dependent proliferation of ALL cellsand reduced the production of IL-6, VEGF, PDGF and CXCL12 in bone marrow stromal cells, Data show that phloretin inhibits cell proliferation via the induction of apoptosis through the activation of p53, JNK and p38 mitogen-activated protein kinase signaling., Results suggest that genistein could inhibit cell growth by inhibiting AKT phosphorylation, ERK1/2 activity and activating p38 MAPK., Exposure of cultured human renal proximal tubular cells to high glucose increased Akt and pMAPK phosphorylation coinciding with increased apoptosis., Cell cycle regulators, AKT, p53, and MAPK, as therapeutic targets for MONCPT to induce cell cycle G2/M arrest in the context of anticancer therapy., Inhibition of apoptosis by GIP is mediated via a key pathway involving Akt-dependent inhibition of apoptosis signal-regulating kinase 1, which subsequently prevents the pro-apoptotic actions of p38 MAPK and JNK., The activation of EGR-1 mediated by p38MAPK pathway plays a critical role in epirubicin resistance of human breast carcinoma cells., Data show that B[a]PDE increases cyclin D1 expression, and activate the PI3-kinase/Akt/MAPK- and p70s6k pathway in Beas-2B bronchial epithelial cells., Results evidence a role for p38 MAPK in activating CREB metabolic pathway in the events leading to erythroid differentiation., Expression of p38alpha is of central importance for osteoclast differentiation and bone resorption in inflammatory arthritis., In leukocytes of patients with stage II and III squamous cell carcinoma (SCC), the p38 MAPK pathway performs an essential role in the induction of iNOS. In advanced-stage SCC, iNOS expression did not seem to be linked with the p38 MAPK pathway., a cell model with DC-SIGN transient transfection to study p38 mitogen-activated protein kinase (MAPK) signaling pathway in response to the E2 treatment, Data revealed that DV infection enhances DC migration by inducing CCR7 expression, and that blocking COX-2 or MAPK activity suppresses DV-induced DC migration., treatment with humanized anti-CD20 monoclonal antibodies inhibited both the constitutively activated NF-kappaB and p38 MAPK pathways, anthocyanins isolated from Vitis coignetiae Pulliat induce apoptosis might at least in part through activating p38-MAPK and suppressing Akt in human colon cancer HCT-116 cells., galectin-7 increases the expression of MMP-9 through the p38 MAPK signaling pathway, IR induces cellular senescence of articular chondrocytes by negative post-translational regulation of SIRT1 via ROS-dependent p38 kinase activation., Data show that the activities of EGFR-MAPK signal pathway were inhibited significantly by overexpression of cav1., Manipulation of p38IP and p38alpha alters mAtg9 localization, suggesting p38alpha regulates, through p38IP, the starvation-induced mAtg9 trafficking to forming autophagosomes., Results suggest that MAPKs are sensors of pressure overload and that extracellular signal-regulated kinase activation in WBCs might be used as a novel surrogate biomarker of uncontrolled hypertension., The possible importance in pediatric myelodysplastic syndromes of p38MAPK signaling pathway which may be a future therapeutic target., This study demonstrates in a cellular model and in patients with tuberculosis that in addition to p38 and NF-kappaB, STAT3 has a key role in driving fibroblast-dependent unopposed MMP-1 production that may be key in tissue destruction in patients., Data suggest that stress kinases (such as p38(MAPK)) as well as HuR are excellent targets for approaches aiming at interfering with induction of COX-2 expression by UVB., The effect of KGF on limbal epithelial cell growth is mediated by upregulation of DeltaNp63alpha through the p38 pathway., Study shows an essential role for apoptosis signal-regulating kinase 1 (ASK1), together with both c-jun-N-terminal kinase (JNK) and p38 pathways, and caspase-8 in Fas-induced apoptosis., Cadein1, preferentially induces apoptosis in p53-defective cancer cells with functional mismatch repair via a p38-dependent pathway, Studies indicate that p38alpha inhibition alone is unlikely to be a successful strategy toward treating chronic inflammatory disorders., during myocardial ischemia, p38alpha (i) is the dominant-active p38 isoform, (ii) contributes to infarction, (iii) is responsible for the cardioprotective effect of SB203580, and (iv) is activated by a mechanism consistent with autodiphosphorylation, p38 MAPK is an important signaling molecule in the ErbB2-induced upregulation of MMP-13 and uPA, rapid phosphorylation of p38 mitogen-activated protein kinase and activating transcription factor 2 also takes place in IM-9 lymphoblastoid cells, which naturally express GPR55, after stimulation with LPI, results demonstrate that IFN-alpha can regulate growth inhibition of Jurkat cells through p38alpha and p38beta, CREG plays a key role in modulating VSMC apoptosis through the p38 and JNK signal transduction pathways, both in vitro and in s, Kiss-1 suppresses MMP-9 expression by activating the p38 MAP kinase signaling pathway., These results suggest that in human tracheal smooth muscle cells, activation of MAPKs, NF-kappaB, and p300 are essential for IL-1beta-induced cPLA(2) expression and PGE(2) secretion., excessive TRPM7 channel activity causes oxidative and nitrosative stresses, producing cell rounding mediated by p38 MAPK/JNK-dependent activation of m-calpain, here report p38 MAPK as a regulator of IL-24 expression and determine interference with destabilization mediated by the 3' UTR of IL-24 mRNA as mode of action, Inhibition of p38 activity or downregulation of p38 expression could overcome the cell-cycle arrest caused by centrobin depletion., Data show T117/T384 as Akt phosphorylation sites in MST2, and mutation of these sites inhibited MST2 binding to Raf-1 but enhanced binding to RASSF1A, accentuating downstream c-jun N-Terminal Kinase and p38 MAPK signaling and promoting apoptosis., p38MAPK is capable of regulating PV IgG-mediated DSG3 internalization, the pathologic interaction of osteoarthritis chondrocytes and osteoblasts is mediated via the activation of ERK-1/2 phosphorylation and deactivation of p38 phosphorylation, resulting in hypertrophic differentiation, These results demonstrate that activin A induces erythroid differentiation of K562 cells through activation of MKK6-p38alpha/p38beta pathway and follistatin inhibits those effects., p38alpha blockade induces the formation of intracellular autophagic vacuoles and reduces growth and viability of ovarian cancer cells., These data demonstrate the novel findings that iPLA2 inhibition activates p38 by inducing reactive species, and further suggest that this signaling kinase is involved in p53 activation, cell cycle arrest and cytostasis., These findings indicate that p38 MAP kinase proteins regulate VE-cadherin junction disassembly, facilitating melanoma migration across endothelial cells., show that p38 MAP kinase directly activates TACE and effects shedding in response to growth factors and Erk MAP kinase activation., miR-34c is a critical regulator of c-Myc expression following DNA damage acting downstream of p38 MAPK/MK2, and miR-34c serves to remove c-Myc to prevent inappropriate replication which may otherwise lead to genomic instability., DJ-1, by directly inhibiting ASK1, may act as a negative regulator in ASK1 signaling cascades., activation of the RhoA-ROCK-p38MAPK-MSK signaling pathway is essential for the regulation of the phenotype and of the CST5/cystatin D candidate tumor suppressor and other target genes by 1,25(OH)2D3 in colon cancer cells, These results suggest that a pathway including p38 MAPK, IKK, and NF-kappaB activation is required for beta-defensin-2 induction in intestinal epithelial cells exposed to Bacteroides fragilis enterotoxin., Hsp90-Cdc37 complex acta as an endogenous regulator of noncanonical p38alpha activity., these results showed that hypoxia induces Bcl-2 expression in human aortic endothelial cells via p38 MAPK pathway., antiproliferative effects of aspirin (at antiinflammatory concentration) on human VSMC obtained from bypass patients are mediated by TGF-beta1 and p38(MAPK), cyclin-dependent kinase 5 is an upstream regulator of neurodegenerative pathways triggered by p38 and a preferable therapeutic target for Alzheimer's Disease, ketamine racemes inhibited fMLP-induced superoxide anion generation and p47(phox) phosphorylation by modulating fMLP-mediated p38 MAPK activation in neutrophils, p38alpha/p38beta and phosphoinositide 3-kinase are crucial to Tat-induced IL-10 production, pro-apoptotic mechanisms orchestrated by p38(MAPK) in human keratinocytes in response to ultraviolet rays B involve an HIF-1/Noxa axis, Nox4, activated via the p38 MAPK - Akt pathway in response to radiation, is the primary source of sustained reactive oxygen species and also potentiates this pathway to induce myofibroblast differentiation., Data demonstrate a relationship between PPARgamma2 expression and chondrocyte lipid metabolism and its regulation by p38 and GSK-3 signalling., Down-regulation of thioredoxin, increased intracellular reactive oxygen species, and activation of ASK1-ERK/p38 MAPK signaling all were associated with Japanese encephalitis virus-induced apoptosis., Data indicate that MMP-2/MMP-9 down-regulation in caffeine-treated U937 cells is elicited by Ca(2+)/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/c-Jun pathway., Carbonic anhydrase XII may affect the capability of invasion and migration of MDA-MB-231 cells, which may be mediated through the p38 MAPK pathway., In CFTRDeltaF508 cells, the extracellular glutathione levels are decreased, leading to a greater sensitivity to reactive oxygen species, providing an explanation for the hyperactivation of the p38 and ERK MAPKs and increased IL-6 synthesis., Data suggest that p38 activity promotes timely checkpoint satisfaction by indirectly influencing those motor proteins (e.g., Klp10, Klp67A) involved in regulating the dynamics of kinetochore microtubule ends., These findings showed that REX1 regulates the proliferation/differentiation of human mesenchymal stem cells through the suppression of p38 MAPK signaling via the direct suppression of MKK3., Data show that when a Gi/PI3K pathway is partially blocked, C5a receptors stimulate an alternative p38MAPK pathway., Thymic stromal lymphopoietin induced proinflammatory gene expression in human airway smooth muscle cells involved ERK1/2, p38, and JNK, and STAT3 activation., The p38 stress-responsive pathway was affected in skin exposed to simulated solar radiation., In conclusion, PKC activation, opening of mitoK(ATP) channels and p38 MAPK activation in early reoxygenation induced the postconditioning of human myocardium, in vitro., Apigenin might inhibit the invasion and migration abilities of Caski cells by reducing the MMP-9 expression through suppressing the p38 MAPK signaling pathway., Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway, IL-12p40 production induced in dendritic cells by nickel sulfate is mainly dependent on p38 mitogen-activated protein (MAP) kinase and nuclear factor-kappa B (NFkB) pathways; this production is independent of the jun-NH2-terminal kinase (JNK) pathway., high molecular weight of HA suppressed the FN-f-activated p38 via ICAM-1 and the CD44 in RA chondrocytes, Findings suggest that Gadd45b mediates p38-induced Rb phosphorylation by enhancing the interaction between p38 and Rb during Fas-induced apoptosis in murine hepatocytes., The stimulation of p38 MAPK by DDR2 was required for DDR2-induced activation of Runx2 and OCN promoters., Hsf4b could interact with and phosphorylated by MAP kinase P38., abrogation of NF-B signaling in human neutrophils resulted in sustained p38 activation in neutrophils, expression elevated in coal-combustion-type fluorosis, influenced by selenium, mediates activation of TGF-beta2 promoter response elements leading to high cytokine expression in cancer cells, EGFP-LEDGF-HaCaT cells had increased expression of IL-6 VIA P38 MAPK, palmitate-induced ROS generation and that NOX3-derived ROS may drive palmitate-induced hepatic insulin resistance through JNK and p38(MAPK) pathways., AMPK regulates glucocorticoid actions on carbohydrate metabolism by targeting the glucocorticoid receptor (GR) and modifying transcription of glucocorticoid-responsive genes in a tissue- and promoter-specific fashion., Iron deficiency enhances atheroma inflammation through p38 MAPK-NF-kappaB-EMMPRIN/MMP-9 pathway., The p38 SAPK is recruited to chromatin via its interaction with transcription factors., Selective knockdown or pharmacological inhibition of MAPK14 had a dramatic effect on p53(-/-) tetraploids, causing the activation of the spindle assembly checkpoint., p38 MAPK is a determinant of virus infection that is dependent upon MyD88 expression and Toll-like receptor 4 (TLR4) ligation, The mechanism of synergistic activation of NF-kappaB by bacterial fMLP and TNFalpha may be involved in the induction of RelA acetylation, which is regulated by p38 MAPK., Inhibitors of MAPK pathway ERK1/2 or p38 prevent the IL-1{beta}-induced up-regulation of SRP72 autoantigen in Jurkat cells., P188 affects stress-related p38 signaling, apoptosis-related GSK3, and inflammation-related IL-6 signaling., data demonstrate that tensin1 is extensively phosphorylated on Ser/Thr residues in cells and phosphorylation by p38 MAPK regulates the specificity of the tensin1 Src homology 2 domain for binding to different proteins, These results provide a direct evidence for the involvement of CD44 in the hyaluronan-dependent regulation of osteoclast activity., Continuous activation of endothelial cells can cause a switch of the p38 MAP kinase from anti-angiogenic to pro-angiogenic activities in conditions which link oxidative stress and autocrine TNF production., The expression of P-P38 increased with the increasing drug resistance of hepatocellular carcinoma cells., Data show that phosphorylation by p38 triggers an interaction between Rb and the Hdm2, leading to degradation of Rb and cell death., nonfibrillar Abeta 1-42 downregulates glutamate transporters activity interfering with p38-activation, Smad2/3 and p38 MAPK differentially regulate TGFB1-induced epithelial-mesenchymal transition in pulmonary epithelial cells., Interaction of Snail and p38 mitogen-activated protein kinase results in shorter overall survival of ovarian cancer patients., p38 MAPK negatively regulates the proteasome activity by phosphorylating Thr-273 of Rpn2, p38alpha MAPK is therefore not required for the loss of intercellular adhesion in pemphigus vulgaris, but may function downstream to augment blistering via Dsg3 endocytosis, Activation of p38 MAPK in endothelial cells by von Willebrand factor is responsible for the regulation of endothelial cell adhesiveness for mesenchymal stem cells., Studies indicate that cysteine oxidation controls a functional redox switch regulating the intensity or duration of p38 activity., Nag-1 induction following NSAID treatment is mediated by the p38 MAPK pathway, p38 maintains E-cadherin expression by suppressing TAK1-NF-kappaB signaling, thus impeding the induction of epithelial-to-mesenchymal transition in human primary mesothelial cells., abilities of two computational approaches, molecular dynamics simulations and anisotropic network model normal mode analysis, for generating potential ligand-bound conformers starting from the apo state of p38, Crystallography of active and inactive mutants of p38alpha MAPK showed that substantial changes in interlobe orientation, extended conformation of the activation loop, and formation of substrate docking site are associated with p38alpha MAPK activation., The upstream molecule of the TRAIL-induced MAPK activation is MEKK, as opposed to ASK1, via the mediation of its signal through JNK/p38 in a caspase-8-dependent manner., Tanshinone IIA acts via p38 MAPK to induce apoptosis and the down-regulation of ERCC1 and lung-resistance protein in cisplatin-resistant ovarian cancer., Rho family proteins, actin polymerisation and p38 MAP kinase have roles in regulation of the endothelial plasminogen activator system by fluvastatin, study demonstrated a novel physical and functional association between N-cadherin and p38 MAPK and suggested neuroprotective roles of cadherin-based synaptic contact, p38 MAPK and JNK antagonistically control senescence and cytoplasmic p16INK4A expression in doxorubicin-treated endothelial progenitor cells, Data show that the apoptosis mechanisms underlying this sensitization mainly involved diosgenin-induced p38 MAPK pathway activation and subsequent DR5 overexpression., These results strongly suggest that NADPH oxidase-derived ROS-mediated activation of p38 and ERK 1/2 is essential for the M. bovis BCG-induced CCL2 production., LFA-1-induced stabilization of ARE-containing mRNAs in T cells is dependent on HuR, and occurs through the Vav-1, Rac1/2, MKK3 and p38MAPK signaling cascade, Acacetin inhibits the invasion and migration of human non-small cell lung cancer A549 cells by suppressing the p38alpha MAPK signaling pathway., The p38 MAPK is critical for the growth inhibitory effect of UC-MSCs on leukemic tumor cells., p38 MAPK signaling pathway is an important contributor to the abnormal differentiation of DC in Primary effusion lymphoma (PEL)., attenuating the inflammatory milieu by inhibiting p38 MAPK activity improves NO activity, human rhabdomyosarcoma RD cell differentiation is regulated by reciprocal, functional interactions between myostatin, p38 and extracellular regulated kinase signalling pathways, the ability of LZAP to alter p38 phosphorylation depended, at least partially, on the p38 phosphatase, Wip1, [review] p38 MAPK, which has generally been linked to stress-related signal transduction, may be an important mediator in the development of AIDS and HIV-associated neurocognitive disorders (HAND)., p38 MAPK upmodulates canonical 3' end processing components and phosphorylates the RNA-binding proteins FBP2 and FBP3, Results suggest that the p38alpha, MAPK, and MKK6 play prominent roles in IL-1beta and C/EBP-beta-mediated C3 gene expression in astrocytes., Data show that IL-32alpha stimulates Fas and ULBP2 expression via activation of p38 MAPK, which increases NK susceptibility of chronic myeloid leukemia cells., Osteopontin stimulates autophagy directly through integrin/CD44 and p38 MAPK-mediated pathways in vascular smooth muscle cells, ATP induces HB-EGF synthesis and release by interacting with the P2 purinergic receptor and through p38 and ERK1/2 signaling in response to a challenging environment., Activation of p38 MAPK in the placenta of patients with preeclampsia induced increased levels of sFlt-l and sEng in maternal serum., Both MAPK-Erk1/2 and MAPK-p38 participate in IGF-I-induced signaling pathways for progesterone production, while insulin-induced progesterone production requires MAPK-p38, but not MAPK-Erk1/2., a novel molecular mechanism that cocaine-activated p38 MAPK-mediated phosphorylation of NET-T30 dictates surface NET availability, and hence, NE transport., lupulone-triggered enhanced expression of p38 plays a major role in the activation of p53 and of the TRAIL-death receptor apoptotic pathway in SW620 human colon cancer-derived metastatic cells, Results indicate that DUSP1 suppresses iNOS expression by limiting p38 MAPK activity in human and mouse cells., Tension force activates Ras-p38 MAPK pathways in PLF, which up-regulate p21 and arrest cell cycle progression at the G(1) phase in periodontal ligament fibroblasts., Data show that suppression of microglial MMP-2 secretion by M tuberculosis-infected monocytes involves the pro-inflammatory mediators TNF-alpha, p38 MAP kinase and NFkappaB in addition to a novel caspase 8-dependent pathway., Results show that silibinin decreased MMP-2, MMP-9, u-PA, p-p38, and p-Erk1/2 expressions in a concentration-dependent manner., The expression of p38MAPK is up-regulated in salivary adenoid cystic carcinoma., Data show that DNA damage stimulates the formation of a cytosolic complex of ATM, NEMO, RIP1, and TAK1, and that TAK1 mediates the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage., Demonstrate antinociceptive effects in acute pain with preoperative administration of a p38alpha MAPK inhibitor., Induction of autophagy by H2O2 depends on the induction of intracellular production of reactive oxygen species (ROS) and activation of the p38 mitogen-activated protein kinase alpha (p38 MAPKalpha) pathway., Imbalance in PRA/PRB ratio frequently associated with carcinogenesis might be a direct consequence of disorders in MAPK signaling., Data indicate that curcumin potentiates antitumor activity of gefitinib through inhibition of proliferation, EGFR phosphorylation, and altering p38 mitogen-activated protein kinase (MAPK) activation in intestinal epithelia cell., p38 MAPK negatively regulates EGF-induced MMP-1 expression by suppressing the activations of ERK and JNK., overexpression of RAB45 increased the phosphorylation levels of p38, resulting in the induction of apoptosis and inhibition of proliferation of CML progenitor cells, DUSP9/MKP-4 is a bona fide target of PKA signaling and attenuation of DUSP9/MKP-4 function can mediate cross-talk between the PKA pathway and MAPK signaling through both ERK1/2 and p38alpha in vivo, Brk expression in human breast tumors may contribute to progression by inducing p38-driven pro-survival signaling pathways., infectious bronchitis virus (IBV) infection of cultured cells activated p38 MAPK pathway and induced expression of IL6 and IL8; IBV has developed a strategy to counteract induction of IL6 and IL8 by inducing expression of dual-specificity phosphatase 1, Alpha1-adrenoceptor signaling in the human prostate involves regulation of p38 mitogen-activated protein kinase, study showed elevated p38alpha level at cancer diagnosis and a statistically significant decline during-RT and post-RT periods. Hence, it can emerge as a prognostic marker supporting the candidature of p38alpha as a suitable serum marker in HNSCC, p38alpha MAPK is involved in BMP-2-induced odontoblastic differentiation of HDPCs., IL-1beta-induced CCL27 gene expression in normal human keratinocytes is regulated through the p38 MAPK/MSK1/Mnk1+2 as well as the IKKbeta/NF-kappaB signalling pathways., Norepinephrine could stimulate pancreatic cancer cell proliferation, migration and invasion through a beta-adrenergic receptor-dependent activation of P38/MAPK pathway., Lysophosphatidic acid activates p38 MAPK signaling in hepatocellular carcinoma promoting cell migration, invasion and adhesion., Data suggest that in non-small cell lung cancer (NSCLC) cells, ERCC1 is induced by etoposide through the p38 MAPK pathway, and this phenomenon is required for NSCLC survival and resistant DNA damage., a novel paradigm in which a fraction of the cellular RARalpha pool is present in membrane lipid rafts, where it forms complexes with G protein alpha Q (Galphaq) in response to RA, interplay between p38 phosphorylation and p58(IPK) upregulation has key roles in modulating ERp29-induced cell-growth arrest and survival, inhibiting p38 reduced histone H3 acetylation at the promoters of SRF target genes, FOS and JUNB, A novel TF/FVIIa/MAPK/c-Fos/MMP-7 axis plays an important role in modulating the invasion of colon cancer cells., The authors found that p38 was activated in monocyte-derived macrophages from healthy donors and patients with acute Q fever in response to a potent agonist such as lipopolysaccharide., antiproliferative effect of SOCS-1 was attributable not only to the inhibition of STAT3 but also to that of p38 MAPK activity, Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21(Cip1) expression and hampers tumour cell growth in vitro and in vivo., p38 phosphorylation of FOXO3a on Ser-7 is essential for its nuclear relocalization in response to doxorubicin., These findings suggest that p38 MAPK may negatively modulate tissue repair functions of endothelial cells via p65 independent pathway., Data suggest aberrant MAP2K protein (MKK3, MKK4, MKK6, and MKK7) expression indicates that altered cellular signal transduction mediated via JNK and p38 may be common in bladder cancer., Suggest that in pancreatic ductal carcinoma p38MAPK expression correlated to shorter postsurgical recurrence-free and overall survivals., Propofol inhibits the activation of p38 through up-regulating the expression of annexin A1 to exert its anti-inflammation effect, the balance between MKK6 and MKK3 mediates p38 MAPK associated resistance to cisplatin in NSCLC, The results we obtained demonstrated that p-p38 plays a key role in the malignant transformation of esophageal squamous cell carcinoma., Lipopolysaccharide-induced ICAM-1 synthesis in human umbilical vein endothelial cells is regulated by GEF-H1/RhoA-dependent signaling pathway via activation of p38 and NF-kappaB., Advanced glycation end products may play an important role in the impairment of diabetic wound healing by upregulating MMP-9 expression in keratinocytes via the RAGE, ERK1/2 and p38 MAPK pathways, and activation of NF-kappaB., MAP17 is overexpressed in late-stage breast tumors, in which oncogenic activity relies on p38 insensitivity to induce intracellular ROS., Phosphorylation OF p38MAPK increased immediately postexercise in human skeletal muscle, results indicate that PS2 modulates the degradation of RBP-Jk through phosphorylation by p38 MAPK., Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes, The translocation of NF-kappaB p65 subunit to the nucleus was also inhibited by the addition of SB203580 or dexamethasone., Data show that MAPKAP kinase 2 overexpression is associated with expression of p38 MAP kinase and ETV1 in gastrointestinal stromal tumors (GIST)., Inhibition of extracellular signal regulated kinase 1/2 and c-jun N-terminal kinases increases, but that inhibition of p38 mitogen-activated protein kinase decreases M. tuberculosis-induced CD44 surface expression in THP-1 human monocytes., Three-dimensional docking in the MAPK p38alpha., A distinct interaction mode revealed by the crystal structure of the kinase p38alpha with the MAPK binding domain of the phosphatase MKP5., p38 MAPK signalling was not up-regulated in skeletal muscle of stable out-patients with COPD, EGF and HGF induced cell migration in human oral squamous carcinoma cell lines was dependent on the MEK ERK, the p38 and the PI-3 kinase pathways for both growth factors., The MAPK p38 acted as a noncanonical G protein-coupled receptor kinase that phosphorylated the formyl peptide receptor FPR1 and facilitated neutrophil migration by blocking the G protein-coupled receptor kinase GRK2 function., the role of TAK1 in cell death, cell cycle regulation and apoptosis after X irradiation is independent of NF-kappaB, p38 MAPK, and ERK phosphorylation, and dependent, in part, on p21 induction, PLD acts as an important regulator in Bcl-2 expression by activating STAT3 involving the phosphorylation of Ser727 through the PLA(2)/G(i)/ERK1/2, RhoA/ROCK/p38 MAPK, and Rac1/p38 MAPK pathways., The activation of both JNK and p38 mitogen-activated protein kinase mechanotransduction cascades is a crucial intracellular mechanism that mediates cyclooxygense-2/prostaglandin E2 and inducible NO synthase/nitric oxide production., P38alpha plays a dual role in mast cell development by regulating IL-3-induced differentiation of mast cell progenitor cells as well as by regulating stem cell factor-induced migration of fully differentiated mast cells., ETS1, ERK2 and Mxi2 are important complex partners initiating increased p16(INK4a) and p21w(af1/cip1) activation in renal tumor cells., Upon activation by ursolic acid , P2Y2 activated Src which in turn phosphorylated p38 leading to COX-2 overexpression which induced resistance to apoptosis in both colorectal and prostate cancer cells, Thus, in endothelial cells p38alpha mediates apoptotic signaling, whereas p38beta and p38gamma transduce survival signaling, MAPK14/p38alpha is a modulator of ex vivo stem cell proliferation and show that pharmacologic inhibition of p38 dramatically enhances the stem cell activity of cultured umbilical cord blood derived hematopoietic cells., HBP activated by GlcN increases PAI-1 expression and eNOS uncoupling depending on p38mapk, which not only explains hyperglycemic vascular complications, but also, The effects of CXCL10 in activated human primary T lymphocytes in terms of apoptosis or survival, and delineated the signaling pathways that are involved, were investigated., miR-20a acts in a feedback loop to repress the expression of MKK3 and to negatively regulate the p38 pathway-mediated VEGF-induced endothelial cell migration and angiogenesis, Data show that p38 MAPK, ERK1/2, and COX-2 activation are mediators for the galectin-1-promoted tumor progression and chemoresistance in lung cancer., systemic administration of p38 MAPK inhibitors in rodents and humans suggest that direct intrapulmonary delivery of a p38 MAPK inhibitor is less effective in inhibiting inflammation, By increasing MKP-1 expression via parallel p38 MAPK- and CREB-mediated pathways, S1P temporally regulates MAPK signaling pathways by upregulating the negative feedback controller MKP-1., Data show in pulmonary microvascular endothelial cells (HPMECs), unfractionated heparin (UFH) significantly attenuated LPS-induced production of IL-1beta, IL-6, E-selectin and ICAM-1, as well as phosphorylation of p38 MAPK and NF-kappaB translocation., Fluorophore labeled kinase detects ligands that bind within the MAPK insert of p38alpha kinase., LMNA missense mutation caused abnormal p38alpha signaling in dilated cardiomyopathy., IL-8-Rac1/RhoA-p38MAPK signaling pathway plays a vital role in the IL-8-induced endothelial cell migration., HIV-1 interaction with dendritic cells modulated their functionality, causing them to trigger the activation of the P38MAPK/STAT3 pathway in T cells., p38 has a role in regulating E2F1 expression and epirubicin resistance., In addition, a signalling network involving the p38alpha pathway, the activation of p53 and the regulation of the miR-17-92 cluster has been identified., Results indicate that TAK1 and p38 kinases appear to be central in the 'priming effect' of LTB(4) on neutrophils to enhance response to Toll-like receptor ligands., Potential MAPK14-CNR1 gene-gene interactions may mediate brain morphometric features in schizophrenia patients with heavy marijuana use., a critical role of NF-kappaB-dependent up-regulation of miR-125b, which forms a negative feedback loop to repress p38alpha activation and promote cell survival upon UV radiation., fluid shear stress involved in PDL remodeling via regulating MMP-1, 2 and TIMP-1, 2 expression. ERK regulated fluid shear stress induced MMP-1 expression and P38 play a role in fluid shear stress induced MMP-2 upregulation., analysis of the X-ray structure of p38alpha bound to TAK-715 and comparison with three classic inhibitors, Results indicated that p38 MAPK may be a key regulator for non-canonical Beclin1-independent autophagy., p38 MAPK, a key regulator of hypoxia in the cerebrovasculature, is increased in the brains of Alzheimer's disease patients., association of the transmembrane domain of CD154 in lipid rafts is necessary for CD154-mediated Akt and p38 activation with consequent enhancement of IL-2 production, Exendin-4 ameliorates high glucose- and TNF-alpha-induced HUVEC-12 cell damage by inhibiting the expression of p38 MAPK protein and translocation of NF-kappaB p65., The study reveals involvement of the TGF-beta inducible p38 MAPK pathway as a possible signalling cascade in the pathogenesis of Dupuytren's disease., Cigarette smoke and its component acrolein augment IL-8/CXCL8 mRNA stability via p38 MAPK/MK2 signaling in human pulmonary cells., the link between p38 and c-Met is implicated in the progression of human cholangiocarcinoma., Overexpression of SHP2 and p38 enzymes in astrocytes led to elevated CXCL8 expression; however, inactivating SHP2 and p38 with dominant negative mutants abrogated CXCL8 induction, the Rit-p38-MSK1/2 signaling pathway may have an important role in the stress-dependent regulation of CREB-dependent gene expression., We demonstrate that the presence of other accessory binding sites of the MMTV construct contributes to the inhibitory effect of activated p38 or JNK on the MMTV-driven transcriptional activity., Data indicate that RO 90-7501 significantly promoted both TLR3 and RLR ligand-induced IFN-beta gene expression and antiviral response, most likely via selective activation of p38 mitogen-activated protein kinase (MAPK) pathway., Structural and biochemical characterization of the alphaEF/alphaF loop identified Trp197 as a key residue in the lipid binding and in p38alpha catalytic activity., The balance between Bax and Mcl-1 protein expression, and theinvolvement of p38MAPK and ERK1/2 signaling pathways in the control of Mcl-1 expression were investigated in obstructive sleep apnea patients undergoing nightly intermittent hypoxia episodes., the possible exacerbation of the radiation-induced endothelial inflammatory response by its interactions with immune cells, p38alpha alone controls acute stress and cytokine signaling from p38 MAPK to translation machinery and p38alpha mRNA in neuronal cells is regulated by miR-124 and miR-128, Data indicate that induction of autophagy by glucose is mediated by p38 MAPK., findings suggest that activation of p38 and ERK, in part through signaling lymphocyte activation molecule (SLAM) mediates T-cell IFN-gamma production in response to M. tuberculosis, a pathway that is defective in patients with tuberculosis, The human respiratory syncytial virus-induced sequestration of p38-P in IBs resulted in a substantial reduction in the accumulation of a downstream signaling substrate, MAPK-activated protein kinase 2 (MK2)., Reduced MAPK14 expression evokes unanticipated increases in vascular smooth muscle cell contractile genes, suggesting an unrecognized negative regulatory role for MAPK14 signaling in cell differentiation., activation of PP2A or inactivation of the p38MAPK-MAPKAPK2-Hsp27 has a role in survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity, human cardiac fibroblasts express the alpha, gamma and delta subtypes of p38 MAPK, and the alpha subtype is important for IL-1alpha-induced IL-6 and MMP-3 expression in this cell type., The p38 mitogen-activated protein kinase signaling pathway was inhibited by probiotics., MAPK14-mediated phosphorylation of ATG5 has a role in inhibiting autophagocytosis, TNF-alpha modulates functions of HPAECs negatively through p38alpha. This may play a role in endothelial cell-mediated tissue repair, especially in an inflammatory milieu where TNF-alpha is present., Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2., p38alpha appears to play a conserved and critical hepatoprotective function by curtailing reactive oxygen species accumulation in liver parenchymal cells, p38 MAP kinase signaling to adherens junction proteins regulates cell aggregation., In the myeloid immune system p38alpha modulates IL-12 and IL-10 production in mouse and human., MRK is a novel RhoC effector that controls LPA-stimulated cell invasion at least in part by regulating myosin dynamics, ERK and p38, studies indicated 38 MAP kinase is a positive regulator of PDX-1 stability and p38 exerts its stabilizing effect on PDX-1 through a phosphorylation-dependent inhibition of PDX-1 ubiquitination., P38 indirectly promotes apoptosis via ERK1/2 inhibition but directly causes coxsackievirus B3-induced necrosis., p38alpha MAPK is implicated in tumor angiogenesis through direct tumoral effects and through reduction of proangiogenic cytokine secretion via the microenvironment., p38 MAPK signaling modulation enhances dendritic cell activation of human CD4+ Th17 responses to ovarian tumor antigen, There exists a threshold of p38alpha MAPK activation required to trigger host defense mechanisms against P. aeruginosa. Planktonic PsaDM induces a stronger p38alpha MAPK activation as compared to biofilm PsaDM., Inhibition of p38 partially reversed the epithelial-to-mesenchymal transition changes in MCF-7 cells and decreased drug resistant tumor growth in a xenograft model., ER stress-induced ASK1-p38 activation, which is triggered by the accumulation of Ins(C96Y), plays an important role in the pathogenesis of diabetes., The JNK and p38 MAPK pathways might be critical mediators in chlorpyrifos-induced neuronal apoptosis by both generating ROS and up-regulating COX-2., a role of p38 signaling in regulating the formation of cytoplasmic vacuoles., P38 MAPK and COX-2 keep monensin-stressed U937 cells alive., TRAIL-induced activation of p38 and JNK have counteracting effects on Mcl-1 expression leading to pro- or anti-apoptotic effects, respectively., The MAPK14 locus was exemplarily explored by typing of haplotype single nucleotide polymorphisms (SNP) confirming this association., These findings unveil a link between PRMT1 and p38alpha in regulating the erythroid differentiation program., IL-10 modulates oxLDL-induced apoptosis by upregulating SOCS3, which then interrupts p38 MAPK activation in endothelial cells., Data suggest that the actions of cryptolepine are probably mediated through NF-kappaBp65 and p38MAPK signalling., cAMP signalling decreases the level of the p300 protein by promoting its ubiquitin-proteasome dependent degradation, which is mediated by Epac and p38 MAPK, Deacetylated GM3 enhances the metastatic phenotype by activating p38 signaling through uPAR/integrin signaling with FAK, PI3K, and Src kinase as intermediates., Data indicate that p38 MAPK and toll-like receptor 2 (TLR2) are required for pLGV440_p5 (ORF5) protein induced tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and interleukin-8 (IL-8) in human monocyte., The roles of protein phosphatases including MAPK phosphatase-1 (MKP-1) and protein phosphatase type 2A (PP2A) in modulating p38MAPK activation and downstream TNF-alpha expressions in primary human monocyte-derived macrophages, were examined., Overexpression of p38alpha in peripheral blood mononuclear cell is associated with head and neck squamous cell carcinoma., Dengue virus induces CD137 signaling to enhance apoptosis by increasing TNF-alpha production via activation of p38 MAPK., p38 MAPK plays a role as a mediator of serine phosphorylation of STAT1., Nrf2 transcription factor was activated and regulated the expression of genes involved in antioxidant response while p38(MAPK) regulated the appearance of premature senescence., p38MAPK inhibition is a new combined approach to reduce neuroblastoma resistance under etoposide treatment., Prx I is an antioxidant that is up-regulated in a reactive oxygen species/p38 MAPK-dependent manner and governs the progression of neuroinflammation by suppressing microglial activation., Results show that stromal cell-derived factor-1 (SDF-1) enhanced ovarian cancer cell invasion through alphavbeta6 integrin-mediated urokinase-type plasminogen activator (uPA) expression via the p38 MAPK and PI3 K/Akt pathway., PGE2 induces MUC2 and MUC5AC expression in intrahepatic biliary epithelial cells via EP4-p38MAPK signaling., Pneumolysin produced by Streptococcus pneumoniae is required for inducing hos beta-defensin 2 whose expression is under the control of p38 MAP and MKP1., 4-Hydroxy-2-nonenal increases TF coagulant activity in monocytic cells through a novel mechanism involving p38 mitogen-activated protein kinase activation that leads to enhanced phosphatidylserine exposure at the cell surface., Data indicate that suppression of p38 MAPK can augment the efficacy of arsenic disulfide (AsS) to induce HL-60 cell differentiation., DEF pocket in p38alpha facilitates substrate selectivity and mediates autophosphorylation, Data show that IFN-gamma induced the production of IL-12/23p40 and IL-23p19 mRNA as well as IL-12p40 and IL-23 proteins positively regulated by the p38 mitogen-activated protein kinases (MAPKs) in monocytes, study shows Tip60 plays an essential role in oncogenic ras-induced senescence; revealed a cascade of posttranslational modifications involving p38, Tip60 and PRAK, 3 proteins essential for ras-induced senescence; these modifications are critical for prosenescent function of Tip60 and PRAK, Data found that p38/AP-1 could be the major inhibitory pathway in the NGACP-mediated anti-inflammatory response., the induction of apoptosis by HIV-1 Tat in retinal pigment epithelial cells may be mediated by p38 MAPK and NF-kappaB activation and involve the mitochondrial pathway., Data indicate that the activation of MAPK and PI3K pathways resulted in TGF-beta1 signaling by down-regulating Nm23-H1 expression and up-regulating the expression of TbetaRI and TbetaRII, favoring further activation of multiple signaling pathways., An unexpected role of p38 in cell cycle regulation in response to Aurora B inhibition, by promoting the transcriptional elongation of the cell cycle inhibitor p21., changes in p38 mitogen-activated protein kinase expression together with recycling of adhesion receptors from the endosome leads to endothelial cell adhesion., COX-2-induced radioresistance is negatively regulated through the phosphorylation of p38 at Tyr182., MKK3/6-dependent activation of p38MAPK is required for the phosphorylation of eIF4E, thus initiating the translation of ER stress-related transcription factor ATF4, Flt-1 in colorectal cancer cells is required for the tumor invasive effect of placental growth factor through a p38-MMP9 pathway, p38alpha phosphorylates P450c17 in a fashion that confers increased 17,20 lyase activity., provide the first evidence to demonstrate that 1,25-(OH)2D3 activates MMP13 expression through p38 pathway in chondrocytes, these results indicate that CAPE potentiated TRAIL-induced apoptosis in SK-Hep1 cells, through upregulation of TRAIL receptors via modulation of p38 and JNK signaling pathways, MAP kinase p38 and retinoblastoma protein signaling is required for DNA damage-mediated formation of senescence-associated heterochromatic foci in tumor cells., the p38/SirT1 axis has a role in angiotensin-converting-enzyme inhibition counteracting of angiotensin II-mediated endothelial cell dysfunction, the cellular senescence caused by CXCR2 upregulation depends on p53 and is mediated by p38 activation., These findings indicate crosstalk between p38 and smad3 through TGF-beta1 in choriocarcinoma cells., novel GrB-EH(ITSN)-dependent pathogenic p38(MAPK)/Elk-1 signaling pathway involved in the poorly understood process of PL formation in severe PAH., Targeting p38 MAP kinase, regulating its role in inflammatory cytokine synthesis. [Review], P38 MAPK was found to be expressed in all tumor specimens and was significantly overexpressed in estrogen receptor+ tumors. P38 MAPK expression was lower in triplenegative breast cancers than in all of the other tumors., p38i restored IL-12 to normal levels, mechanical stretch can promote magnitude-dependent proliferative modulation through PKC and possibly JNK but not via p38MAPK in human bladder smooth muscle cells., analysis of the interaction of the MAPK binding domain of DUSP16 with p38alpha, Suggest that IL-17A enhances the migration of PDL fibroblasts by increasing MMP-1 expression through the IL-17 receptor, p38 MAPK, and NF-kappaB signal transduction pathways., Regulation of P38alpha by STEP and PTPRR involves differential interaction modalities., Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor kappaB activation., IL-4 induces cellular senescence through independent signaling pathways involving STAT6 and p38 MAPK in some human renal cell carcinoma cell lines., Depletion of miR-181 family members by miRNA inhibitors enhanced the expression of MKP-5 and suppressed the phosphorylation of p38 MAPK after exposure to PAHs, which promotes cancer cell migration., the shear-induced apoptosis and autophagy are mediated by bone morphogenetic protein receptor type (BMPR)-IB, BMPR-specific Smad1 and Smad5, and p38 mitogen-activated protein kinase., p38alpha MAPK signaling plays a role in autoimmune myeloid cells, revealing important molecular mechanisms that underlie sex differences in disease pathogenesis., DUSP1 impairs NF-kappaB activity through a mechanism involving p38 MAPK inhibition., upregulated GRP78 expression may be antiapoptotic effects and the p38/MAPK pathway was involved in the process of cigarette smoke extractinduced GRP78 expression in A549 cells., S-adenosylmethionine limitation induces MAPK14 and triggers cell cycle arrest in G1., These data demonstrate for the first time that extracellular histones, especially H4, play a vital role in lymphocyte apoptosis during sepsis which is dependent on p38 phosphorylation and mitochondrial permeability transition., Thus, inhibition of MAP kinase p38 may be an antiviral strategy that protects mice from lethal influenza by suppressing excessive cytokine expression., Interleukin 33 has a role in enhancing the p38 MAPK and PKA signaling pathways in melanocytes, After MeCP2 siRNA treatment, p-ERK1/2 levels decreased, but p-p38 levels increased., p38alpha has a role in downregulating the eNOS activity and NO production in human endothelial cells, Activation of p38 MAPK is associated with disease progression and increased angiogenesis and lymphangiogenesis in human head and neck squamous cell carcinoma., Data support a potential link between NOB1 and p38 MAPK expression and prognosis in prostate carcinoma., HIV-1 Tat-mediated induction of CCL5 in astrocytes involves NF-kappaB, AP-1, C/EBPalpha and C/EBPgamma transcription factors and JAK, PI3K/Akt and p38 MAPK signaling pathways, of c-Myb, is detected preferentially in nonSUMOylated protein and has a negative effect on stress-induced SUMOylation of c-Myb. Stress-activated p38 MAPKs phosphorylate Thr(486) in c-Myb, attenuate its SUMOylation, p38alpha negatively regulates survival and malignant selection of transformed bronchioalveolar stem cells., Results indicate that phosphorylation of epidermal growth factor receptor pathway substrate 15 (Eps15) at Ser-796 is catalyzed by p38 directly., results demonstrated that p38 and ERK1/2 played crucial positive roles in adipogenesis, and FAK, RhoA/ROCK and cytoskeleton played negative roles, P38 MAPK plays an important protective role in silver nanoparticle-induced oxidative DNA damage-repair., Data indicate LY2228820 potently and selectively inhibited p38alpha MAPK substrate phosphorylation., Tissue factor inflammatory response regulated by promoter genotype and p38 MAPK in neonatal versus adult microvascular endothelial cells., that KAT5 RNAi may result in cleaved casp9 upregulation through p38MAPK activation in Gallbladder carcinoma cells, ANGPTL2 expression in OS cell lines correlated with increased tumor metastasis and decreased animal survival by promoting tumor cell intravasation mediated by the integrin alpha5beta1, p38 mitogen-activated protein kinase, and matrix metalloproteinases, CXCL4 and CXCL4L1 activated p38 MAPK, as well as Src kinase within 30 and 5 min, respectively. Extracellular signal-regulated kinase (ERK) phosphorylation occurred in activated lymphocytes., the IL-1beta/p38/AP-1(c-fos)/MMP2 & MMP9 pathway play an important role in metastasis in gastric adenocarcinoma, Enhanced p22(phox) expression causes vascular dysfunction through ERK1/2 and p38-mitogen-activated protein kinase-dependent mechanisms in male type 2 diabetic mice., Notably, NAADP-mediated Ca(2+) release in intact cells is regulated by Mg(2+), PI(3,5)P2, and P38/JNK kinases, thus paralleling regulation of TPC2 currents., We found that both of these factors significantly suppressed gelsolin-induced cardiac hypertrophy through p38/GATA4 signaling pathway., distinct p38/ERK pathways are related to E-cadherin levels and function downstream of E-cadherin allowing, respectively, for hepatocyte-mediated MErT and tumor cell survival in the face of death signals., p38MAPK plays a crucial role in stromal-mediated tumorigenesis, Differential roles for p38alpha and p38beta in the HGF-induced expression of key osteogenic markers., Epstein-Barr virus infection induces IDO1 expression in macrophages through p38 and NF-kappaB pathways., Pretreatment of T24 cells with the antioxidant N-acetylcysteine (NAC) significantly inhibited activation of caspase-3 and MAPK-p38 and prevented inactivation of Akt and Bcl-2, Data show that salvianolic acid B protects endothelial progenitor cells against oxidative stress by modulating Akt/mTOR/4EBP1, p38 MAPK/ATF2, and ERK1/2 signaling pathways., activation of p38 and JNK pathways may revert resistance of TP53-mutated cells to spindle poisons., analysis of signaling cooperation between p38-MAPK/MAPKAP-2/Hsp27 and intracellular calcium release in AA-induced HBEC apoptosis, p38 MAPK and IL-6 signaling in patients with breast cancer may improve prognosis and treatment of metastatic breast cancer., During free radical stress, hUCBC paracrine factors activate myocyte Akt, which increases myocyte viability by decreasing activation of death-promoting protein kinases JNK and p38., Inhibition of p38 MAPK signaling augments skin tumorigenesis via NOX2 driven reactive oxygen species generation., The phosphorylation status of MAPKs is closely associated with the signal transduction of extracellular stimuli to cellular responses and accounts for the formation of vascular inflammation and diseases., Then, activated p38 further enhanced the docking of activating transcription factor 4 (ATF4) onto the CHOP (CCAAT/enhancer-binding protein homologous protein) promoter via eIF2alpha to enhance apoptosis, JNK1/2 and p38 MAPK signaling pathways are beneficial to enterovirus 71 infection and positively regulate secretions of inflammatory cytokines in dendritic cells., results suggested that p38 is activated during the serial passagings of normal human fibroblast, which results in the repression of hTERT transcription and induction of cellular senescence, Our results support a potential mechanism by which high plasma SFA levels through p38alpha activation may lead to the development of lipotoxic/diabetic cardiomyopathy., uncover a new mechanism of deactivation of MKK6-p38 and substantiate a novel regulatory role of FBXO31 in stress response, Modulation of radiation injury response in retinal endothelial cells by quinic acid derivative KZ-41 involves p38 MAPK., The rational design of specific peptide inhibitor against p38alpha MAPK at allosteric-site, role of p38mapk in Arg-II-induced eNOS-uncoupling was investigated in cultured human endothelial cells overexpressing Arg-II in the absence or presence of shRNA against p38mapk, Molecular details of the interaction between dually phosphorylated, active human p38alpha and the C-terminal fragments of its substrate MK2., Desensitization attenuated basophil response rapidly and non-specifically at a stage before p38 MAPK phosphorylation., AMPK activation using AICAR inhibited cell proliferation and survival by activating p38 MAPK and proapoptotic molecules in FRO thyroid cancer cells., The MAPK14-driven metabolic reprogramming sustains the production of NADPH resulting in reduced levels of reactive oxygen species, phosphorylated-p38 was a negative independent prognostic factor for colorectal cancer, describe fundamental metabolic requirements of senescent primary human CD8+ T cells and demonstrate that p38 MAPK blockade reverses senescence via an mTOR-independent pathway, IFN-beta-induced apoptosis of human SH-SY5Y neuroblastoma cells is associated with a long-lasting up-regulation of p38 MAPK activity., The immunomodulatory ability of human mesenchymal stem cells gradually declines with consecutive passages via a p38-mediated alteration of COX-2 and prostaglandin E2 levels., one of the targets of p38 in this context is another GATA transcription factor, GATA3, recently demonstrated to promote HSC cycling and restrict their long-term reconstitutive potential downstream of p38 in stress-induced hematopoiesis [9]., Shock wave treatment induced ATP release, increased Erk1/2 and p38 MAPK activation, and enhanced proliferation in three different cell types, Data indicate that mitogen-activated protein kinase (MAPK) p38 activation is triggered by AMP-activated protein kinases (AMPK) and mediated by TAB1 protein., findings confirm that p38 and PAX2 are important for the Dvl-3 induced upregulation of p120ctn, Results suggest that piperine may exert at least part of its anti-cancer effect by controlling interleukin-6 (IL-6) expression through the suppression of p38 MAPK and STAT3 protein., uPA/uPAR stimulates triglyceride synthesis in Huh7 hepatoma cells via p38-dependent upregulation of DGAT2, knockdown of Sec8 enhances the binding of JIP4 to MAPK kinase 4, thereby decreasing the phosphorylation of MAPK kinase 4, JNK, and p38., Results showed that the protein levels of endothelial lipase (EL), NF-kappaB p65, MAPK p38 protein levels, in addition to the proliferation of umbilical vein endothelial cells (HUVECs), were increased by angiotensin II (AngII)., Data indicate that integrity of the p38 MAPK signaling is necessary for the antioxidant function of liver kinase B1 (LKB1)., Data indicate that GATA1 transcription factor is downregulated in ribosomal protein S19 (RPS19)-deficient cells through upregulation of TNF-alpha and p38 MAPK., The data obtained allow suggesting that alpha7-specific antibody can provoke neuroinflammation within the brain by inducing IL-6 production via p38 MAPK in astrocytes., phosphorylation of sterol regulatory element-binding protein (SREBP)-1c by p38 kinases, ERK and JNK, Data show that PGC-1beta protein mediated the expression of proinflammatory cytokines and apoptosis through extracellular signal-regulated kinase (ERK), p38 and NF-kappaB in rheumatoid arthritis fibroblast-like synoviocytes., p38 MAPK was identified as a key regulator of the expression of proinflammatory gene sets, and p38 MAPK activation was found to be increased in the diabetic vs. control myotubes., miR-125a-3p is negatively correlated with the development and maintenance of orofacial inflammatory pain via regulating p38 MAPK, FK-3000 exerts its antiproliferative effect through G2/M cell cycle arrest via downregulation of cyclin B and phospho-CDC2 by p38 MAPK phosphorylation and CDC25B dephosphorylation ., The expression levels of the proapoptotic proteins Bax and Bak were increased after the RF-PI treatment, resulting in more caspase-3 and -9 activity. This was reversed in the presence of p38MAPK inhibitor SB203580., P28(GANK) interacted with p300 to attenuate assembly of RelA with p300., Treatment with MK2 or p38 inhibitors blocked human papillomavirus genome amplification, identifying the p38/MK2 pathway as a key regulator of the human papillomavirus life cycle., Prdx1 associates with the formation of membrane protrusions through modulation of the activity of p38 MAPK, which in turn promotes pancreatic ductal adenocarcinoma cell invasion., These results suggest that the localization of ZO-1 in cell-cell contacts is differently regulated by activation and inhibition of JNK and/or p38 MAPK depending on the incubation period., Results demonstrated that the p38 MAP kinase signaling pathway is essential for MMP-9 upregulation in pericytes in response to TGF-beta1 stimulation, Data indicate that high mobility group box 1 (HMGB1) induces Pp38 MAPK pathway., data suggest that the p38alpha MAPK pathway is linked with RLR signaling pathways and regulates the expression of early IFN genes after RNA stimulation cooperatively with IRF3 and NF-kappaB to induce antiviral responses further, Data indicate that tetra-substituted pyridinylimidazoles were designed as dual inhibitors of c-Jun N-terminal kinase (JNK) 3 and p38alpha mitogen-activated protein (MAP) kinase, and both kinases may be involved in the progression of Huntington's disease., reduced expression in abdominal adipose tissue from obese subjects, Inhibition of p38MAPK activation accelerated cell apoptosis, meanwhile enhanced autophagy may act as a cytoprotective process in SW620 cells., Our data provide evidence that RAGE mediates oxLDL-induced activation of p38 and JNK MAPK and the osteogenic differentiation of VICs., Hepatitis B virus transfection could induce TEMT in HK-2 cells, which was mediated by the TGF-beta1/p38 MAPK pathway., Data suggest that p38 MAP kinase regulates c-fos/cellular oncogene fos mRNA stability/decay by affecting state of phosphorylation of Elavl1/HuR (Hu antigen R)., The obtained results strongly indicate the pyrazolobenzothiazine core as a new p38alpha inhibitor chemotype worthy of future chemical optimization efforts directed toward identifying a new generation of anti-inflammatory agents., TACC3 depletion induces G1 arrest and cell death by activating p38-p53-p21 signaling and triggering a centrosome-mediated cellular stress response., Arg-II, p38, and S6K1 form a positive circuit which regulates endothelial senescence and cardiovascular aging., Quinacrine-induced K562 cell apoptosis is mediated through mitochondrial alterations triggered by p38 MAPK-mediated BCL2 down-regulation and suppression of ERK/c-Jun-mediated BCL2L1 expression., A p38 MAPK/Nrf2 signaling is a key molecular network contributing to temozolomide resistance of glioma., Estrogen receptor beta 2 regulates IL12RB2 expression via p38 MAPK signaling and inhibits non-small-cell lung cancer proliferation and invasion., Helicobacter pylori induces internalization of EGFR via novel TAK1-p38-serine activation pathway which is independent of HB-EGF., investigated whether blocking the surface inhibitory receptor PD-1 and/or p38 MAP kinase could enhance the proliferation of the effector memory CD8(+) T-cell subset that re-expresses CD45RA (EMRA) and exhibits characteristics of senescence, TTP function is controlled by p38 MAPK, and its expression in airway smooth muscle cells is p38 MAPK-dependent and its anti-inflammatory activity is also controlled by p38 MAPK-mediated phosphorylation., We demonstrated that the MAP4 (Ser696 and Ser787) phosphorylation increased concomitantly with the p38/MAPK pathway activation by the LPS and TNF-alpha stimulation of HPMECs, which induced MT disassembly followed by hyperpermeability., Our findings demonstrate that signalling through FPR-1 and activation of p38 and ERK1/2 MAPKs are key events in mtDAMP-induced neutrophil activation, results indicate that a TNFR1/RIPK1/P38 axis is present in adenosine-induced apoptosis of colonic cancer cells. This axis triggers apoptosis and plays crucial roles in relay of the death signaling, PKCtheta; acts through the activation of p38 MAPK and autophagy induction to induce the Epstein-Barr virus (EBV) lytic cycle., p38 MAP kinase is activated in response to IFN-gamma and causes actin rearrangement and altered cell morphology, which in turn mediates endothelial cell hyperpermeability., mitophagy in mammalian cells predominantly occurs through an alternative autophagy pathway, requiring the MAPK1 and MAPK14 signaling pathways, Study confirms the effectiveness of encapsulated p38 MAPK inhibitors in extended drug delivery systems and seems to be a promising strategy for intra-articular treatment., TLR8, but not TLR7, is involved in priming of human neutrophil reactive oxygen species production by inducing the phosphorylation of p47phox and p38 MAPK., Report down-regulation of aquaporin3 expression by lipopolysaccharide via p38/c-Jun N-terminal kinase signalling pathway in HT-29 human colon epithelial cells., Data indicate the involvement of the p38 MAPK/NF-kappaB/IkappaBalpha pathway in Newcastle disease virus (NDV) infection and subsequent induction of apoptosis in clear cell renal cell carcinoma (ccRCC) cells., SR-B1 and p38 MAPK are involved in signaling pathway of serum amyloid A-induced angiogenesis in rheumatoid arthritis., blockade of CD82 in leukemia cells lowered EZH2 expression via activation of p38 MAPK signaling., These findings suggest that RACK1 specifies the RANKL-stimulated activation of p38 MAPK by facilitating the association of MKK6 with TAK1, Suggest that the p38 signalling pathway, by modulating the Th17 differentiation and response, is involved in the pathogenesis of multiple sclerosis., Staurosporine induces platelet apoptosis via the p38 MAPK signaling pathway., These results raise the potential that proinflammatory responses such as p38 activation and IL-6 formation are augmented in Gaucher's disease., stichoposide D inhibits growth of experimental leukemia by activating Fas/ceramide synthase 6/p38 kinase in lipid rafts, Knockdown of Wip1 enhances sensitivity to radiation in HeLa cells by inhibiting cell proliferation and inducing apoptosis through activation of p38 MAPK., Results indicate that L. mexicana amastigotes have the capacity to diminish MAP kinases p38 and JNK activation and activate PI3K and AKT pathways, which is probably one of the strategies employed by L. mexicana amastigotes to inhibit apoptosis in the infected monocyte-derived dendritic cells., Data suggest PGE2 induces aromatase and ERB/ESR2 expression by interacting with c-Jun and p38a/MAPK14, thus influencing estradiol production in endometrial stromal cells; inactivation of c-Jun and p38a may be effective in treatment of endometriosis., Immunohistochemical analysis of DKK-1 expression in 97 breast cancer samples revealed that high expression of p38 was associated with a higher expression of DKK-1 compared to tumours with low p38 expression., Data show increasing concentrations of valproic acid (VPA) increase P38 MAP kinase synthesis. in hRPE cells., Suppression of ATAD2 impaired the growth of HepG2 and Hep3B subcutaneous xenografts, by enhancing apoptosis and p-p53 and p-p38 levels., Findings indicate that CARMA3 may suppress the activation of the P38 MAPK signaling pathway to regulate invasion, migration and apoptosis of lung cancer cells by activating NF-small ka, CyrillicB (P65) in the nucleus., MKK3 overexpression upregulated the cyclin-dependent kinase inhibitors, p16 INK4A and p15 INK4B in hepatocellular carcinoma cells was Bim1, was downregulated following MKK3 overexpression., FAM172A protein is expressed at high levels in human papillary thyroid carcinoma, which may promote cell proliferation via activation of the p38 MAPK signaling pathway., a linear p38-MK2-14-3-3 signalling pathway that specifically targets CEP131 to trigger centriolar satellite remodelling after cell stress., p38alpha MAPK plays a critical role in the regulation of BACE1 degradation and Abeta generation in Alzheimer Disease pathogenesis, Taken together, our data show that enhanced expression of endothelial TF, which plays an important role in coagulopathy and splenic vein remodeling in liver cirrhosis, is induced by IL-17A in a ROS dependent manner.,
OFFICIAL_GENE_SYMBOL MAPK14,
SP_COMMENT catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases., enzyme regulation:Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K3 or MAP2K6, and potentially also MAP2K4. Inhibited by dual specificity phosphatases, such as DUSP1. Specifically inhibited by the binding of pyridinyl-imidazole compounds, which are cytokine-suppressive anti-inflammatory drugs (CSAID). Isoform Mxi2 is 100-fold less sensitive to these agents than the other isoforms and is not inhibited by DUSP1. Isoform Exip is not activated by MAP2K6., function:Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis., online information:P38 mitogen-activated protein kinases entry, PTM:Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily., similarity:Contains 1 protein kinase domain., subunit:Binds to a kinase interaction motif within the protein tyrosine phosphatase, PTPRR. This interaction retains MAPK14 in the cytoplasm and prevents nuclear accumulation. Interacts with SPAG9 (By similarity). Interacts with NP60 and FAM48A., tissue specificity:Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney.,