Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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mitogen-activated protein kinase 11(MAPK11) mitogen-activated protein kinase 11(MAPK11) Related Genes Homo sapiens
CYTOBAND 22q13.33,
GENERIF_SUMMARY p38 MAP Kinase suppresses the function of Mirk as a transcriptional activator only when cells are proliferating, the p38MAPK activation-Bax expression pathway might be involved in apoptosis induced by oxidative stress, Neurotoxicity of pneumolysin depends on activation of p38 mitogen-activated protein kinase., activation of p38 MAPK is involved in the mitochondrial activation-mediated cell death pathway, Activities of aPKC (P<0.05) and ERK 1/2 (P=0.06), but not phosphorylation of P38 MAPK, were higher in trained than in sedentary subjects at rest., SAPK2/p38 intervenes in the control of MonoMac6 cell migration induced by monocyte chemoattractant protein-1., phosphorylation of Y1214 on VEGFR2 is required to trigger the sequential activation of Cdc42 and SAPK2/p38 and to drive the SAPK2/p38-mediated actin remodeling in stress fibers in endothelial cells exposed to VEGF, These results suggest that bFGF can negatively modulate p38 and positively modulate ERK1/2 to antagonize activin A-mediated growth inhibition and Hb synthesis in K562 cells., SAPK2/p38 mitogen-activated protein kinase is inhibited by PML in tumor cells, cholesterol depletion alters involucrin gene expression through activation of p38alpha/beta., p38SAPK might be involved in the regulation of cyclin D3 levels and suggest that this mechanism is involved in the maturation of precursor T-cells, p38alpha and -beta mediate UV-induced, AP-1-mediated, c-Fos phosphorylation, p38 phosphorylation occurred in response to attack by Staphylococcus aureus alpha-toxin and streptolysin O, commencing within minutes after toxin treatment and waning after several hours., The authors characterized the multisite phosphorylation of the ATF7 activation domain and identified one of the involved kinase, p38beta2 mitogen-activated protein kinase., genistein protects human vascular endothelial cells against tumor necrosis factor-alpha-induced apoptosis through the p38beta mitogen-activated protein kinase, Specific isoforms of p38 and their sub-cellular localization may have different roles in modulating ischemic injury., results demonstrate that IFN-alpha can regulate growth inhibition of Jurkat cells through p38alpha and p38beta, These results demonstrate that activin A induces erythroid differentiation of K562 cells through activation of MKK6-p38alpha/p38beta pathway and follistatin inhibits those effects., show that p38 MAP kinase directly activates TACE and effects shedding in response to growth factors and Erk MAP kinase activation., p38alpha/p38beta and phosphoinositide 3-kinase are crucial to Tat-induced IL-10 production, Overexpression of p38beta or Rac1 significantly enhanced (1.9- and 3.9-fold, respectively), the tRA-stimulated NIS expression in MCF-7 cells., Thus, in endothelial cells p38alpha mediates apoptotic signaling, whereas p38beta and p38gamma transduce survival signaling, Study identifies Hsp27 as a novel target of ILK-p38beta signaling complexes, playing a key role in bladder cancer cell migration., inhibition of the SOCE downstream target CaM kinase kinase beta (CaMKKbeta) or knockdown of AMPKalpha1 suppressed PAR-1-mediated phosphorylation of p38beta and hence STIM1., p38beta is a novel regulatory target of the transcription factor Pokemon and positively regulated by Pokemon in hepatic cells., Differential roles for p38alpha and p38beta in the HGF-induced expression of key osteogenic markers., study identified the structural motif responsible for the unique autophosphorylation capability of p38beta and the motif inhibiting this activity in living cells, Data show that the p38 MAPK (p38) isoform (p38beta) mitogen-activated protein kinase 11 (MAPK11) is expressed in breast cancer cell., The MAPK11 gene was variably methylated in monozygotic twins discordant for depressive disorder., These findings suggest that coronin 1A modulates endothelial cell apoptosis by regulating p38beta expression and activation., Suggest that R-Ras regulates angiogenic activities of endothelial cells in part via inhibition of the p38MAPK-HSP27 axis of VEGF signaling.,
SP_COMMENT catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases., enzyme regulation:Activated by phosphorylation on threonine and tyrosine by MKK6. Inhibited by pyridinyl-imidazole related compounds., function:Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. Phosphorylates preferentially transcription factor ATF2., PTM:Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme., similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily., similarity:Contains 1 protein kinase domain., tissue specificity:Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas.,