Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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mitogen-activated protein kinase 3(MAPK3) mitogen-activated protein kinase 3(MAPK3) Related Genes Homo sapiens
CHROMOSOME 16,
CYTOBAND 16p11.2,
ENSEMBL_GENE_ID ENSG00000102882,
GENERIF_SUMMARY MEK1 interacts with ERK1. This interaction is mediated via a conserved N-terminal docking site in MEK1., Unregulated activation of STAT-5, ERK1/2 and c-Fos may contribute to the phenotypic transformation from myelodysplastic syndrome to acute leukaemia. Impaired ERK1/2 signalling pathways were activated only by GM-CSF but not by Epo., role in acidic extracellular pH in inducing VEGF in human glioblastoma cells, Extracellular signal-regulated kinase (ERK1 and ERK2) activation is required for GP Ibalpha-dependent endothelial cell migration., CD40 ligation induces macrophage IL-10 and TNF-alpha production, p42/44MAPK regulates baseline permeability and cGMP-induced hyperpermeability in endothelial cells, role of activation in TFF-peptide-stimulated bronchial epithelial cell migration and tumor necrosis factor-alpha-induced interleukin-6 and IL-8 secretion, ML-1-induced IL-6 and IL-8 production is mediated through the activation of ERK1/2, role of activation in IGFBP-5 stimulation of growth and IGF-I secretion in intestinal smooth muscle, Protease activity, growth factor-like and kringle domains of uPA differentially contribute to activation of p42/p44erk1,2 and p38 MAP-kinases., Activation of the p44 MAPK pathway contributes to the underlying mechanism of IL-12 suppression by soluble CD40 ligand., Down-regulation of ERK1 and ERK2 activity during differentiation of the intestinal cell line HT-29., Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells. A role for HER2 AND PKC-delta, eNOS expression might be regulated by PI-3K and the ERK1/2 signaling pathway, Eicosapentaenoic acid and docosahexaenoic acid modulate MAP kinase enzyme activity in human T-cells, ERK1 activity ad dual-phosphorylation were undetectable in expanding and self-renewing hematopoietic progenitors (HP). Adding IL-3, inducing maturation and cell death in HP, led to sustained high levels of ERK1 activity and dual-phosphorylation., Provant Wound Closure System induces activation of p44/42 MAP kinase in normal cultured human fibroblasts, ERK activation by cAMP does not require RAP1, Role of ERK1 in BRCA1-induced apoptosis, Control of mycobacterial replication in human macrophages, ITGB1 activated by ERK1/2, p38 MAPK after hypoxia, connective tissue growth factor induced fibronectin production, cell migration, and cytoskeletal rearrangement are associated with recruitment of Src and phosphorylation of p42/44 MAPK and protein kinase B, EPO induces long-lasting phosphorylation of MAPK p42/44 in vascular endothelial cells, activating signal pathways increasing the thrombogenicity of their extracellular matrices., expression of extracellular signal-regulated kinase, ERK1, and its relationship with clinicopathological characteristics of breast cancer, LMP1 inhibits transforming growth factor-beta 1-mediated induction of MAPK/p21 in Epstein-barr virus infected gastric epithelial cell line GT38, report the activation of the extracellular signal-regulated kinases (ERKs) 1 and 2 (p44 and p42 MAP kinase) through the human serotonin receptors 5-HT(4(b)) and 5-HT(7(a)), Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways, Decreased phosphorylation of protein kinase B and erk1/erk2 in neutrophils from patients with myelodysplastic syndrome, Data show that p-MEK1/2 and p-ERK1/2 are present in neurons in the initial stages of neurofibrillary degeneration in Alzheimer's disease, before deposition of beta-amyloid., Persistent activation of ERK1/2 by lead acetate increases nucleotide excision repair synthesis and confers anti-cytotoxicity and anti-mutagenicity., Helicobacter pylori-induced ERK1 activation, especially by the cagA(+) strain, may play a protective role against gastric epithelial cell apoptosis partially through maintenance of bcl-2 gene expression, inhibition amplifies ajoene-induced cell death in human promyeloleukemic cells, pp90RSK- and protein kinase C-dependent pathway regulates p42/44MAPK-induced LDL receptor transcription in HepG2 cells., NiCl2 induced that of p44/42 extracellular signal-regulated kinases, p38, and stress-activated protein kinase/c-jun N-terminal kinases., acute hyperglycemia-mediated mononuclear cell activation is dependent on activation of ras, p42/p44 mitogen-activated protein kinase phosphorylation, and subsequent NF-kappaB activation, HDL induced a potent signal through a Ras/MAPK pathway mediated by a pertussis toxin-sensitive G-protein coupled receptor to the angiogenic phenotype in HCECs., stretch of airway smooth muscle causes production of interleukin-8 by activating CCAAT/enhancer-binding protein and activator protein-1 transcription factor through activation of extracellular regulated kinase-1 and 2 and p38 kinase signaling pathways, EGF & ionizing radiation up-regulate the DNA repair genes XRCC1 & ERCC1 in DU145 & LNCaP prostate carcinoma, showing a complex control of DNA repair activation that may be more generally dependent on MAPK (ERK1/2) signaling than previously noted., p38 and ERK1/2 have roles in coordinating cellular migration and proliferation in epithelial wound healing, ERK1 is activated in a pathway that involves MKP1 and ubiquitin-proteasome, The 1,25(OH)(2)D3-responsive element in cystatin A gene is identical to TRE, T2 (-272 to -278). Suppression of Raf-1/MEK1/ERK1,2 signaling pathway increases cystatin A expression of normal human keratinocytes., the active phosphorylated form of MAPK/ERK is aberrantly expressed in cultured and primary HD cells, antiproliferative effect of the heme oxygenase-1 pathway in airway smooth muscle in vitro and in vivo through a bilirubin-mediated redox modulation of phosphorylation of ERK1/2, Results suggest that receptor activator of NF-kappaB ligand (RANKL) induction by high extracellular calcium might not be mediated by the G protein-coupled calcium-sensing receptor, but by the p44/42 mitogen-activated protein kinase pathway., Lipopolysaccharide-induced matrix metalloproteinase (MMP)-1 and MMP-9 production by monocytes is regulated by ERK1 through a mechanism involving the activation of additional MMP promoter sites via a PGE2-independent mechanism., ERK1 activity is regulated by p38 delta MAP kinase, ERK1/2 signaling is regulated by B-raf in melanocytes, Neutrophil elastase-induced PGE2 release involved activation of p44/42, but not p38, MAP kinases., ERK-1/ERK-2 active in salivary gland mucoepidermoid carcinoma. Activation is associated with more aggressive tumor behavior and higher proliferative activity. Deregulation contributes to mucoepidermoid carcinoma phenotype. Target for anticancer drugs., results indicate that activation of PKC is responsible for GnRH-induced phosphorylation of both ERK1/2 and Pyk2, and that Pyk2 activation does not contribute to GnRH signaling, Alterations in MAPK pathways in part regulate peripheral microvascular dysfunction after CPB in humans., IGF-I signals osteoblast mitogenesis and survival through parallel, partly overlapping intracellular pathways involving PI-3 kinase, p42/44 MAPKs, and G beta gamma subunits., agonists of PPAR alpha increased basal and insulin-stimulated PAI-1 antigen release with a mechanism involving gene transcription and requiring signaling through the ERK1/2 signaling pathway, activation of Sphingosine kinase 1 results directly from phosphorylation of Ser225, and evidence shows that the activating kinase is ERK1/2 or a close relative, results suggest that ERK may play important roles in the control of microvilli structure and possibly, in brush border-associated responses in differentiated intestinal epithelial cells., phosphorylation of PPARgamma was mediated through the ciglitazone-induced activation of Erk1/2, nNOS can differentially regulate the ERK signal transduction pathway in a manner dependent on the presence of l-arginine and the production of NO*., Treatment of insulin receptor-overexpressing cells with insulin or vanadyl sulfate resulted in a time-dependent transient increase in phosphorylation and activation of extracellular signal-regulated kinases 1 and 2., Elevated levels of phosphorylated ERK 1/2 were detected in monocytes after 2 h of NANase treatment, persisting for 2 additional hours. Desialylation of cell surface glycoconjugates also led to increased production of IL-6, MIP-1alpha, and MIP-1beta., Activities of aPKC (P<0.05) and ERK 1/2 (P=0.06), but not phosphorylation of P38 MAPK, were higher in trained than in sedentary subjects at rest., JCV-induced signal activates the mitogen-activated protein kinases ERK1 and ERK2 when JC virus is binding to human glial cells, p44MAPK has a role in glucose-enhanced interleukin-6-induced VEGF165 expression, ERK1/2 activation with calcium requires Galphai2 coupling and dynamin-independent receptor internalization, results suggest that physiological levels of beta-arrestin1 may act as "dominant-negative" inhibitors of beta-arrestin2-mediated extracellular signal-regulated kinases 1 and 2 activation, epidermal p44/42 and p38 mitogen-activated protein kinases are activated by acute cutaneous barrier disruption, extracellular signal-regulated kinases 1 and 2 are activated by cyclic AMP, RSV attachment to A549 cells activates both ERK-1 and ERK-2 pathways within 5 min. Inhibition of ERK pathways significantly decreases RSV infection, demonstrating that the activation of the ERK-1/2 is required in RSV-induced early gene expression., ERK1 and ERK2 have roles in functional activation of estrogen receptor alpha in human tumor cells by leptin, examination of expression of p53, p21, and phosphorylated p42/44 mitogen-activated protein kinase in human pulmonary arterial smooth muscle cells, ERK may contribute to non-caspase-dependent pathways of injury after ER stress in SH-SY5Y human neuroblastoma cells., The signal transduction pathway of VEGF transcription in HepG(2) cells may be through PI3K pathway, but not through p42/p44 MAPK pathway., Acute vasoconstrictor effects of insulin in skeletal muscle arterioles are mediated by activation of ERK1/2 in endothelium. This effect antagonizes insulin-induced, PI3-kinase-dependent vasodilatation in skeletal muscle arterioles., Lipoteichoic acid-stimulated p42/p44 MAPK phosphorylation is mediated through a TLR2 receptor and involves tyrosine kinase, PLC, PKC, Ca(2+), MEK, and PI 3-kinase., sustained activation of p44/42 MAPK perhaps forms the stimulatory signal induced by low TGF-beta1, whereas activation of p38 forms the inhibitory pathway, insulin stimulates Na(+),K(+)-ATPase activity and translocation to plasma membrane in HSMCs via phosphorylation of the alpha-subunits by ERK1/2 mitogen-activated protein kinase., ERK1/2 and p38 MAPK have roles in suppressing apoptosis of colon cancer cells via cyclic AMP, LFA-1 induced the activation of src family kinases, Vav1 and p44/42 mitogen-activated protein kinase (MAPK), in human CD56+ NK cells, The character of extracellular signal-regulated kinase 1 activation, transient or sustained, acts as a signal integrator to quantify the strength of T cell receptor engagement and direct the cellular response., Agonist-mediated metalloproteinase activation in C9 cells led to shedding of heparin-binding EGF (HB-EGF) and stimulation of ERK1/2 phosphorylation, ERK1/2 is important for ER cytoplasmic localization in breast cancer cells, Activation of FAK and ERK1/2 by MCSP appear to involve independent mechanisms., ERK1 and ERK2 play a major role in ovarian cancer pathogenesis and down-regulation of this master signaling pathway is highly effective for the inhibition of ovarian tumor growth., ERK 1/2- and p38 MAPK-modulated TIMP-2 expression regulates MT1-MMP activity and control TGF-beta1-induced pericellular collagenolysis, role of ERK in the cytotoxicity mediated upon activation of the D1 dopamine receptor., These results suggest that bFGF can negatively modulate p38 and positively modulate ERK1/2 to antagonize activin A-mediated growth inhibition and Hb synthesis in K562 cells., PMA-induced activations of ERK and p38 kinase are parallel events that are both required for inhibition of NO-induced death of Molt4 cells, ERK suppresses stress-induced apoptosis downstream of mitochondrial alterations by maintaining XIAP levels and oxidants block this effect through activation of p38 and protein phosphatases, In Helicobacter pylori-colonized gastric epithelial cells, IL-17-induced IL-8 synthesis is associated with and depends at least in part on the activation of ERK 1/2 MAP kinase., Activated by Trypanosoma cruzi infections in cultured human umbilical vein endothelial and vascular smooth muscle cells., CCL20-stimulated growth of HuH7 cells was abrogated by the inhibition of downstream signal transduction pathway mediated by p44/42 MAPK., Cystathionine gamma-lyase has a role in regulating cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1, Data show how the ability of receptors such as angiotensin type 1A to interact with beta-arrestin 2 determines both the mechanism of extracellular signal-regulated kinase 1 and 2 activation as well as the physiological consequences of this activation., HSF1 associates with ERK1 and 14-3-3epsilon during heat shock to modulate the amplitude of the response and lead to efficient termination of HSP expression on resumption of growth conditions, delayed and sustained ERK activation provides a survival signal to human HaCaT keratinocytes, identified an alternatively spliced 42-kDa form of ERK1, nuclear accumulation of active ERK1/2 is a discrete regulated step that can direct the function of the kinase in response to specific stimuli, Resistin induces HASMC proliferation through both ERK 1/2 and Akt signaling pathways., Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells, NF-kappaB, ERK, and GADD45beta are able to coordinate in a loop-like signaling network to defend cells against the cytotoxicity induced by ionizing radiation, a novel Ras-independent ERK1/2 activation system in which p110gamma/Raf-1/MEK1/2 and PKA/B-Raf/MEK1/2 cooperate to activate ERK1/2., ERK1/2 and JNK1/2 signaling is stimulated by radiation and can promote cell cycle progression in human colon cancer cells, Results indicate that polymyxin B induces a partial maturation of human dendritic cells through increased adhesion and activation of the IkappaB-alpha/NF-kappaB pathway, and that increased ERK1/2 activation inhibits maturation., the protective effect of phorbol-12-myristate-13-acetate on anchorage-independent survival of melanoma cells is partly mediated by MEK-independent activation of ERK1/2 and inactivation of downstream pro-apoptotic effector proteins, MMP-1 expression is maintained at a low level by Cdc42 via a repression of the Rac1 and ERK1/2 pathways when cell/extracellular-matrix interactions via integrins induce cytoskeleton organization, ERK1/2 signaling has a critical role in the regulation of BRCA1 function on controlling the G2/M checkpoint responses, Contributes to insulin signalling upstream of nitric-oxide-dependent cyclic GMP production., OSBP was found to function as a cholesterol-binding scaffolding protein coordinating the activity of two phosphatases to control the extracellular signal-regulated kinase (ERK) signaling pathway, RAS-MEK-ERK1/2 signaling pathway can sensitize cells to TRAIL-induced apoptosis by up-regulating DR4 and DR5, both p38 and ERK1 are spatially regulated in different uterine regions during pregnancy/labor, ERK1/2 mediated GRK2 protection could be a general phenomenon as proteasome inhibition increased G protein-coupled receptor kinase 2 expression in two other cell lines, HEK293 and NIH3T3, EGFR-dependent ERK1/2 activity in keratinocytes takes part to a homeostatic mechanism regulating inflammatory responses, In conclusion, the ERK1/2 pathway appears to be unaffected by muscle glycogen content., In cholesteatoma, co-expression of p21 and pERK1/2 was prominent, whereas in retro-auricular skin there was hardly any co-expression., These data support ROS production and p42/44 MAP kinase phosphorylation being involved in a common strain-induced signaling pathway., mast cell chymase activates ERK and p38 probably through G-protein-coupled receptor, and the ERK but not p38 cascade may have a crucial role in chymase-induced migration of eosinophils, GIT1 has a role as a scaffold for ERK1/2 activation in focal adhesions, intracellular M. leprae activates Erk1/2 directly by p56Lck by means of a PKCepsilon-dependent and MEK-independent signaling pathway, Flow activates ERK1/2 and endothelial nitric oxide synthase via a pathway involving PECAM1, SHP2, and Tie2., late sustained ERK1/2 activation plays a role in coxsackievirus B3 replication; virus infection affected several host genes through ERK1/2 activation, CBP and PCAF coactivators mediate ERK1 gene expression at both the transcriptional and post-transcriptional level, in primary fibroblasts stabilization of Ras protein by ROS and ERK1/2 amplifies the response of the cells to growth factors and in systemic sclerosis represents a critical factor in the onset and progression of the disease, ERK activation and p21 and N-cadherin upregulation are required for genistein-induced neuronal differentiation, Together, these results suggest that phosphorylation of Arix by ERK1/2 inhibits its ability to interact with target genes, and that both specificity of expression and modulation by external stimuli are monitored through the same transcription factor., activation of focal adhesion kinase is involved with the aggressive capability in pancreatic cancer through Ras/ERK signaling pathway, PP2A ABalphaC and ABdeltaC holoenzymes function as positive regulators of Raf1-MEK1/2-ERK1/2 signaling by targeting Raf1, A3 receptor stimulation activates p44/p42 and p38 mitogen-activated protein kinases, which are required for A3-induced increase of HIF-1alpha and Ang-2, ERK/PLD2 pathway contributes to fMLP-mediated oxidant production, NPB and NPW (10(-6) M) stimulated tyrosine kinase (TK) and mitogen-activated PK (MAPK) p42/p44 activities in NCI-H295 cells, overexpression of SphK1 up-regulated MMP1 protein, MMP1 mRNA, and MMP1 promoter activity, and this action of SphK1 required activation of the ERK1/2-Ets1 and NF-kappaB pathways, GSK-3, acting through PKCdelta, is a negative regulator of ERK1/2, the beta2 adrenergic receptor has a role in beta-arrestin-dependent, G protein-independent ERK1/2 activation, Transient expression of centaurin-alpha1 in COS-7 cells results in specific activation of ERKs., ERK1 is capable of dimerization both in vivo and in vitro, in gastric epithelial cells, H. pylori up-regulates MMP-1 in a type IV secretion system-dependent manner via JNK and ERK1/2, a novel signaling pathway involving MKK-2 and ERK1/2 may down-regulate the activity of PABP and eIF4E by controlling their phosphorylation and compensates for the effect of excess cellular PABP, HSD-3.8 (SPAG1), interacts with G-protein beta 1 subunit and activates extracellular signal-regulated kinases 1 and 2, Prostacyclin receptor up-regulates the expression of angiogenic genes in human endometrium via cross talk with epidermal growth factor Receptor and the extracellular signaling receptor kinase 1/2 pathway., These results indicate that PI3K plays different roles in the activation of Ras/ERK1/2 signaling by insulin and EGF, and that insulin-stimulated, but not EGF-stimulated, ERK1/2 and Akt signalings diverge at PI3K., IR-induced ERK1/2 activation involves EGFR through a Src-dependent pathway that is distinct from EGFR ligand activation, We concluded that PGE2 stimulates the BNP promoter mainly via EP4, PKA, Rap, and p42/44 MAPK., beta-arrestin and G proteins activate parathyroid hormone receptor-stimulated ERK1/2 pathways, Taken together, these data suggest that abnormally sustained activation of ERK in FAP may represent an early signaling cascade leading to neurodegeneration., MEKs regulate mitosis via all three ERK isoforms; ERK1c acts specifically in the Golgi, whereas ERK1 and 2 regulate other mitosis-related processes. Thus, ERK1c extends the specificity of the Ras-MEK cascade by activating ERK1/2-independent processes., These findings reveal that prolonged ERK1-2/MAPK stimulation results in FADD-independent caspase 8 activation and cell death., dynamin has roles in the IL-5 signaling pathway and in receptor endocytosis and termination of the ERK1/2 signaling pathway, intracellular generation of NO* by nNOS leads to S-nitrosylation of H-Ras, which interferes with Raf-1 activation and propagation of signalling through ERK1/2, seminal plasma and PGE(2) can promote the expression of tumorigenic and angiogenic factors, in cervical adenocarcinoma cells via the EP4 receptor, EGFR, and ERK1/2 signaling pathways, As such, caveolae and caveolin-1 coordinate PDGF receptor signaling, leading to myocyte proliferation, and inhibit constitutive activity of p42/p44 MAPK to sustain cell quiescence., HSP25 and HSP70i activate HSF1 and have roles in inhibition of ERK1/2 phosphorylation, TNFalpha-signaling pathway mediating ERK inhibition suggesta a role for Lnk in the interplay between PI3K and ERK triggered by TNFalpha in vascular endothelial cells., ERK1/2 is activated by a chimeric neurokinin 1 receptor-beta-arrestin1 fusion protein, Rho kinase, myosin-II, and p42/44 MAPK are potentially important players in different aspects of bile canalicular lumen morphogenesis., ERK1/2, JNK1/2 and p38 mapk pathways are all required for B[a]P-induced G1/S transition, results strongly suggest the existence of a bidirectional molecular connection alpha(v)beta(3)-ERK1/ERK2 MAPK that would regulate breast cancer cells survival and proliferation, ERK5 and ERK1/2 differ in their mechanisms of gene regulation, and ERK5 may control hypoxia-responsive genes by a mechanism independent of HIF-1alpha expression control, The results imply that ERK1 may be important for the differentiation of tubular-type cholangiocarcinoma., Expression and activation of ERK1 in the human endometrium was increased particularly during the secretory phase. May be induced by ovarian steroid hormones., CCN2 was critically involved in osteolytic metastasis and was induced by PKA- and PKC-dependent activation of ERK1/2 signaling by PTHrP., Results show that activation of c-Jun N-terminal protein kinase, ERKs 1 and 2, and p38 MAP kinase is critical for Hs683 glioma cell migration induced by GDNF., Results suggest that Dok-4, through activation of the Rap1-ERK1/2 pathway, regulates GDNF-mediated neurite outgrowth during neuronal development., TGF-beta1 regulates COX-2 expression in human mesangial cells through the activation of ERK1/2, p38 MAPK, and PI3K, Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent p85 PI3K and Akt and Erk activation, Down-regulation of MIP-1 alpha was not observed following FGFR3 inhibition in MM cells with RAS mutations implicating RAS-MAPK in MIP-1 alpha regulation, heterotrimeric G protein-dependent ERK1/2 activation is mediated by IGF-1 and IGF-2 by transactivating sphingosine 1-phosphate receptors, activations of ERK1/2 promotes basal dopamine cell survival and protects dopamine cells from oxidative stress, phosphorylation of Ser-641/643 by MAPK promotes the nuclear accumulation and transcriptional activity of hypoxia-inducible factor-1alpha by blocking its CRM1-dependent nuclear export, analysis of the LLKIL motif in CXCR2, which is required for full IL-8 ligand-induced activation of Erk, Akt, and chemotaxis in HL60 cells, C-reactive protein (CRP) activates the MAP-K pathway of renal distal tubular cells (DTC). CRP upregulated RANTES expression of DTC in a significant and dose-dependent manner., ERK1/2 critically regulates 5-LO activity in the absence of additional downstream targets in the survival signalling preventing peroxynitrite toxicity., RS/MEK/ERK signal transduction cascade may provide a potential therapeutic approach in lymphomas and related malignancies that exhibit high levels of MCT-1 protein., ERK1/2 activity is required in early G2 for a timely entry into mitosis but that it does not directly regulate cell cycle progression from late G2 through mitosis in normal or transformed mammalian cells., phosphorylation is a mechanism for regulation of insulin receptor substrate-1/2, Akt, and ERK1/2, apoptosis induced by cannabinoid receptor CB1 and CB2 agonists leads to activation of ERK1/2 leading to G1 cell cycle arrest in prostate cancer cells, These results suggest the existence of an ERK1/2-driven negative feed-back regulation of ERK5 signaling in epidermal growth factor-stimulated HK-2 cells, which is mediated by MKP-3, DUSP5 and/or MKP-1., Leptin and TGF-beta1 synergistically augmented activation of signalling components of mitogen-activated protein kinase (MAPK), STAT3 and Smad but did not modulate the expression of LEPR-B., activation of ERK1/2 in colorectal cancer may indicate aggressive tumor behavior and may constitute an independent prognostic factor; data suggest that mutations of the k-ras oncogene may induce activation of ERK1/2, tumor samples from FMTC patients showed strong nuclear staining of phosphorylated ERK1/2 and Ser(727) STAT3; FMTC-RET mutants activate a Ras/ERK1/2/STAT3 Ser(727) pathway, which plays an important role in cell mitogenicity and transformation., L-phenylalanine and other amino acids enhance the Ca2+o-sensitivity of calcium-channel stimulated ERK1/2 phosphorylation., results firmly establish that angiotensin II activates p44/42 MAPK through protein kinase C epsilon in H295R cells, Directed trafficking of plasma membrane epidermal growth factor receptor is an essential element of signal transduction leading to p42/p44 MAP kinase activation., pneumolysin is required for up-regulation of MUC5AC mucin via TLR4-dependent activation of ERK1 in Streptococcus pneumoniae infections; IKK alpha and IKKbeta are distinctly involved in MUC5AC induction by S. pneumoniae via an ERK1-dependent mechanism, These experiments demonstrate that D(2) receptor (short splice variant, D(2S)R) stimulation increases DAT cell surface expression. Furthermore, they show that the increase in DAT function is ERK1/2-dependent but PI3K-independent., IL-6, via the PI3-kinase/Akt pathway leads to inhibition of the repressive kinases MAPK/pERK and GSK3beta, and this converts inactive HSF-1 to an intermediate DNA-binding form augmenting transcriptional activation in the presence of a second stressor., involved in ascorbic acid-induced osteoblastic differentiation during periodontic ligament cell attachment to type I collagen, Our results suggest that the Hedgehog and ERK1/2 pathways are important for cholangiocarcinoma cell proliferation., These results implicate IR-induced ERK1/2 activation as an important regulator of G2/M checkpoint response to IR in MCF-7 cells., These results strongly suggest that hypoxia-induced apoptosis is regulated through signal transduction in which inactivation of ERK1/2 leads to activation of p38, which then triggers caspase cascade as an execution mechanism of apoptosis., These results suggest that in human tracheal smooth muscle cells, activation of p42/p44 MAPK, p38, and JNK pathways, at least in part, mediated through NF-kappaB, is essential for lipopolysaccharide-induced VCAM-1 gene expression., hSphK2 is phosphorylated on Ser-351 and Thr-578 by ERK1 and phosphorylation of these residues is important for EGF-stimulated migration of MDA-MB-453 cells, CDA1 induces p53- and MEK/ERK1/2 MAPK-dependent expression of p21 by acting through the p53 responsive element in the p21 promoter and this contributes to its antiproliferative activity, These data demonstrate that IGF-I induces COX-2 expression in human ovarian cancer cells, which is mediated by three parallel signaling cascades--PI3K, MAPK, and PKC pathways that differentially regulate COX-2 expression., phosphorylated-ERK1/2 expression was an independent predictor of complete remission achievement in adult acute lymphoblastic, In A2780 cells, ERK1/2 interacts with Cdc25C in interphase and phosphorylates Cdc25C in mitosis. Inhibition of ERK activation partially inhibits T48 phosphorylation, Cdc25C activation, and mitotic induction., Results indicated that p-ERK1/2 expression was an independent prognostic indicator for overall survival., receptor and nonreceptor PTKs have roles in modulating H2O2-induced ERK1/2 and PKB signaling [review], PI3K/Akt activity strongly correlated with proliferation and invasion and p44/42 MAPK was correlated with only invasion., High D-glucose increases L-arginine transport and eNOS expression following TbetaRII activation by TGF-beta1 involving p42/44(mapk) and Smad2 in HUVEC., Fak/Src signaling to the PI3-K/Akt-1 and MEK/Erk pathways undergoes a differentiation state-specific uncoupling in enterocytes., The regulation of three major mitogen-activated protein kinases phosphorylation, ERKp44/p42, p38, and JNK, was determined. The influence of specific mitogen-activated protein kinase inhibitors on IL-1 beta protein levels during beta-endorphin stimulation., KGF triggers negative feedback between ERK1/2 and AKT pathways to regulate cell proliferation/differention., These results demonstrate that 9-cis-Retinoic acid transduces the signal through p38 MAPK and ERK1/2 for CCR1 and CCR2 up-regulation., Proinvasive activity of BMP7 gthrough SMASD4/src -independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells is reported., This review discusses the mechanisms by which activated ERK1/ERK2 regulate growth and cell cycle progression of somatic cells., Activation and phosphorylation of the extracellular signal-regulated kinase 1/2 and AKT pathways are involved in cervical adenocarcinoma metastases to pelvic lymph nodes., Spry2 plays a role as tumor suppressor in NSCLC by antagonizing receptor tyrosine kinase-induced signaling at different levels., GSTP1 contributes to doxorubicin and cisplatin resistance in osteosarcoma, which may be mediated in part by the activation of extracellular signal-regulated kinase 1/2, administration of IL-6 could activate receptor gp80/gp130 signaling pathways including downstream extracellular signal-regulated kinase 1/2 and STAT3 phosphorylation in EPCs., activation of the Erk1/2 by increasing calcium concentration in the incubation medium may compensate for the loss of Akt activation, ERK1/2-dependent dissociation of Bim(EL) from Mcl-1 and Bcl-x(L) may play a role in regulating Bim(EL) degradation, inhibition of the p44/42-MAPK phosphorylation by high-dose acetaminophen could abolish the doxorubicin-induced cell death pathway, These results point to a pivotal role for p38 MAPK pathway during GTP-mediated erythroid differentiation of K562 cells., Epac1 activation in HUVEC results in ERK1/2 activation, and this protein, at least in part, mediates response to the physiologically relevant event of A(2B)AR stimulation, ERK1/2 phosphorylation is impaired in adipocytes from patients with type 2 diabetes, Short waves increase proliferation in human chondrocytes through activation of the ERK pathway., ERK1/2 is involved in monitoring actin dysfunction to control the onset of mitosis, suggesting the presence of an actin checkpoint at the G(2)/M transition in primary mammalian cells., The results show that Hcy activated both ERK(1/2)/p38MAPK pathway and NF-kappaB-DNA-binding activity., Leptin induces CRP expression in HCAECs via activation of the leptin receptor, increased ROS production, and phosphorylation of ERK1/2, that endogenous IGF-1 and IGF-2 receptors can independently initiate ERK1/2 signaling and point to a potential physiologic role for IGF-2 receptors in the cellular response to IGF-2, VEGF, Ets-1, and ERK1 act synergistically in the development of diabetic retinopathy., There was a significant positive linear association between ERK1/2 activity and uPA protein expression in laryngeal squamous cell carcinoma., Thus, the migration of human astrocytes after injury is partly initiated by activation of the MEK-ERK signalling pathway., IL-17 is a potent inducer of CRP expression via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation., ERK expression in patients with IE was significantly increased compared with the controls. This suggested a probable role of ERK in the pathogenesis of IE., expression levels of pSTAT3, pAkt, and ERK1/2 were significantly higher in squamous cell carcinoma, Bowen's disease or basal cell carinoma than in actinic keratosis or vowenoid papulosis, neuropeptide Y has a role in prostate neoplasm growth through MAP kinase/ERK 1/2 activation [review], Identify novel links between the physiological state of the cell, the activation of MEK/ERK1/2 signaling, and the nucleocytoplasmic distribution of AMPK., Hence, our data provide the first evidence that LIV-1 mRNA is overexpressed in cervical cancer in situ and is involved in invasion of cervical cancer cells through targeting MAPK-mediated Snail and Slug expression., ERK1/2 functions as an alternative pathway in BMP-4 signaling in human umbilical vein endothelial cells. Capillary sprouting induced by BMP-4 is dependent on ERK phosphorylation., These findings provide evidence that mutations in fibronectin, induce anoikis in human squamous cell carcinoma cells by modulating integrin alpha v-mediated phosphorylation of FAK and ERK., In human proximal tubular cells ERK1/2 signaling represents an important component of oncostatin M inhibitory effect on N-cadherin expression., Cbl is not required for ERK1/2-dependent Bim(EL) turnover in fibroblasts and epithelial cells., A pathway comprising PKCs>Raf-1>MEK-1>ERK-1/-2 mediates the effect of gastrin on the CgA promoter, and strongly suggests that enhanced phosphorylation of Sp1 and CREB is crucial for CgA transactivation through the G protein-coupled CCK-B/gastrin receptor., RU486 attenuates the activation of ERK1/2, decreases the expression of COX-2, and affects PGE2 production by inhibiting hCG-induced COX-2 expression., IL-17 induces MMP-1 in human cardiac fibroblasts directly via p38 MAPK- and ERK-dependent AP-1, NF-kappaB, and C/EBP-beta activation., Activated protein C may provide cytoprotective activity by activating the ERK pathway, which upregulates EGR-1 thereby suppressing the expression of TRAIL by PAR-1/S1p1 dependent but EPCR independent mechanism., study demonstrates that the ERK1/2 MAP kinase is markedly activated in ystic fibrosis (CF) airway epithelial cells after prolonged oxidative stress and causes an increase in both the production of IL-8 and the expression of CXCR1/2 receptors, IL-15 but not IL-21 caused an increased phosphorylation of Shc and ERK1/2., Shp2E76K induces cytokine-independent survival of TF-1 cells by a novel mechanism involving up-regulation of Bcl-XL through the Erk1/2 pathway., IFNalpha-induced apoptosis requires activation of ERK1/2, PKCdelta, and JNK downstream of PI3K and mTOR, and it can occur in a nucleus-independent manner, thus demonstrating that IFNalpha induces apoptosis in the absence of de novo transcription., Hemin increased Egr-1 expression (mRNA, protein) within 30 minutes and ERK-1/2 phosphorylation and nuclear translocation within 5 minutes, Leptin may promote the proliferation of endometrial cancer Ishikawa cells by activating ERK1/2 signaling pathway., Data show that activation and nuclear translocation of ERK1/2 require Cyclophilin A., beta-arrestin2 supported protein kinase C-independent ERK1/2 activation by the AT1a rceptor, molecular mechanisms leading to glutamate-induced proliferation by determining ERK1/2 and CREB phoshporylation in chick RPE cells in primary culture and the human-derived RPE cell line ARPE-19, it was shown that recognition of C. albicans filaments by neutrophils is mediated via the MEK/ERK cascade and independent of JNK or p38 activation., Taurine was shown to increase cell proliferation and generate an increase in [Mg2+]i accompanied by ERK 1/2 activation in human osteoblast cells., Calcitonin decreases ERK1/2 phosphorylation in cancer cells showing constitutive phosphorylated ERK1/2., Chorionic gonadotropin promotes trophoblast invasion and migration through activation of ERK and AKT signaling involving their downstream effector MMP-2., The production of GRO-alpha, IL-6 and IL-8 was shown to account for the ability of the HeLa cell culture medium to stimulate the migration of monocytes/macrophages, suggesting a key role for p38 MAPK and ERK1/ERK2., Insulin-like growth factor type-I receptor-dependent phosphorylation of ERK1 can be induced by picropodophyllin., Altered osteoblast proliferation in human osteoporosis may result from dysregulation of IGF-I receptor signaling, including constitutive activation of the IRS-2/Erk signaling pathway., Rho kinase and ERK1/2 play more important roles than RhoA in PGE(2)-mediated migration stimulation of first-trimester trophoblasts., Activation of protease-activated receptors but not stimulation with lipopolysaccharides leads to ERK1/2 and JNK-mediated production of IL-8., attenuation of the Erk1/2 signaling pathway is essential for andrographolide-mediated inhibition of v-Src transformation, These results clearly indicate that CCDC134 is a novel member of the secretory family and down-regulates the Raf-1/MEK/ERK and JNK/ SAPK pathways., substance P receptor mediates ERK1/2 phosphorylation in a calcium-dependent manner, RSVL activates the kinase-G system to counteract HP-induced ERK1/2 activation and coronary arterial proliferation, OSBP is able to sense both membrane cholesterol and oxidized sterols and link this information to the ERK1/2 signaling pathway., Our results identify a new mechanism for the disruption of architecture in epithelial acini and suggest that ERK1/2 can promote noninvasive motility in preinvasive mammary tumors., These data suggest that dual recruitment of FcgammaRIIIa and the IL-12R to lipid raft microdomains allows for enhanced activation of downstream signaling events that lead to IFN-gamma production., processing of pre-TNF alpha in LPS-stimulated macrophages is regulated by TPL2-mediated activation of ERK1 and ERK2, [Review] ERK1 activity generated by cytokines, free radicals or other inflammatory factors after stroke may worsen ischemic damage, whereas the ERK1/2 activity produced by exogenous growth factors, estrogen, and preconditioning favors neuroprotection., Concordant overexpression of p-FAK and p-ERK1/2 in extramammary Paget's disease (EMPD) is associated with the grade of malignancy of EMPD., Prorenin and renin-induced ERK 1/2 activation are independent of angiotensin II. The signal transduction is different from that evoked by angiotensin II., G2/M cell cycle arrest is induced by genistein via stable activation of ERK1/2 pathway in MDA-MB-231 breast cancer cells, ERK1/2-mediated phosphorylation of CIITA down-regulates CIITA activity by priming it for nuclear export, thus providing a means for cells to tightly regulate the extent of antigen presentation., Overexpression of MSLN resulted in sustained activation of extracellular signal-regulated kinase 1/2 and suppression of Bim., The formation of an ERK.GSK3beta complex retained pERK1/2 in the cytoplasm., These data suggest that TNF-induces autophagy through ERK1/2 and that inhibition of autophagy increases cellular sensitivity to TNF., Data suggest that TPA stimulates reactive oxygen species generation as a second messenger to activate Erk1/2 via a redox-mediated inhibition of Erk1/2-directed phosphatase in ML-1 cells., Prostaglandin E1 inhibits IL-6-induced MCP-1 expression by interfering specifically in IL-6-dependent ERK1/2., Epidermal growth factor receptor signaling to Erk1/2 and STATs control the intensity of the epithelial inflammatory responses to rhinovirus infection., even upon over-expression DUSP6 fails to inactivate ERK5, confirming that it is indeed an ERK1/2-specific DUSP, CRP increases VEGF-A expression in monocytic cells via a PI3-kinase and ERK 1/2 signaling dependent pathway, results show that IL-15 can improve the function of NK cells via up-regulating NKG2D expression, and also augmenting the expression of cytotoxic effector molecules and the phosphorylation of STAT1 and ERK1/2, which may also contribute the NK lysis, Phosphorylated ERK1/2 was present in almost all tumours and p-ERK1/2 may be a prognostic marker at the invasive front of oral squamous cell carcinomas., hNUDC induced a sustained activation of the extracellular signal-regulated protein kinases-1 and -2 (ERK1/2) as well as p38 mitogen-activated kinase (p38 MAPK) pathways, Probiotic-secretory proteins protect the intestinal epithelium from hydrogen peroxide-induced insult by a PKC beta1/epsilon- and ERK1/2-dependent mechanism., Tissue factor pathway inhibitor prevented ERK1 phosphorylation in endothelial cells to influence angiogenesis., ERK1/2 as an important signaling mediator for the inhibitory effect of THP-1-MacCM on TG accumulation during 3T3-L1 adipogenesis., the capacity of IMP to inhibit signal propagation through Raf to MEK is a consequence of disrupting KSR1 homooligomerization and B-Raf/c-Raf hetero-oligomerization, Preeclampsia is associated with decreased activation of ERK1/2 in invasive trophoblasts in vivo., Pyk2/ERK 1/2 mediate Sp1- and c-Myc-dependent induction of telomerase activity by epidermal growth factor, increased expression of ERK1 and activated p38 can predict poor human sperm quality, These results suggest that induction of OspF is enhanced during Shigella invasion of dendritic cells and decreases the phosphorylation level of Erk1/2., when HARE binds HA, that leads to activation of ERK1/2, important mediators of intracellular signal transduction., Preconditioning signaling cascade involves STAT3 activation after varepsilonPKC and ERK1/2 activation, These data demonstrate the role of Cx43 in the proliferation and migration of human saphenous vein smooth muscle cells and angiotensin II-induced Cx43 expression via mitogen-activated protein kinases (MAPK)-AP-1 signaling pathway., activation of ERK1/2 is implicated in the pathobiology of glioblastoma, c-FLIPL promotes the motility of HeLa cells by activating FAK and ERK, and increasing MMP-9 expression., Data suggest that PLD2 is an early player upstream of the Ras-ERK1/2-IL-2 pathway in T-cells via phosphatidic acid and diacylglycerol production., the induction of inflammatory genes by farnesol is mediated by the activation of the NF-kappaB pathway and involves MEK1/2-ERK1/2-MSK1-dependent phosphorylation of p65/RelA(Ser(276)), inflammatory levels of NO inhibit epithelial cell migration, because of suppression of ERK1/2 signaling, and activation of HIF-1alpha and p53, with potential consequences for epithelial repair and remodeling during airway inflammation, human 14-3-3gamma binds to the ERK1/2 molecular scaffold KSR1, which is mediated by the C-terminal stretch of 14-3-3gamma, Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced ERK1 and ERK2 activation and promotion of migration and invasion of esophageal cancer cells, results suggest a novel B cell-mediated pathophysiological mechanism for the etiology of osteoporosis, which is that downregulation of ESR1 and MAPK3 in B cells regulates secretion of factors leading to altered osteoclastogenesis or osteoblastogenesis, ATP activated MAPKs through the P2Y2 purinoceptor/PLC/PKC/ERK signaling pathway and induced translocation of ERK1/2 into the nucleus., distinct phosphorylation of PKCdelta on tyrosines 64 and 187 specifically activates the Erk1/2 pathway by the down-regulation of MKP-1, resulting in the persistent phosphorylation of Erk1/2 and cell apoptosis, Rapid activation of Stat3 and ERK1/2 by nicotine modulates cell proliferation in human bladder cancer cells., These findings, together with observations that si-hBVR blocked activation of ERK and Elk1 by IGF1 and prevented formation of ternary complex between MEK/ERK/hBVR, define the critical role of hBVR in ERK signaling and nuclear functions of the kinase., Lumican induces cell migration by activating ERK 1/2 signaling and ERK 1/2 stimulates expression of integrin beta1., We demonstrate a role for PI3-K, p42/44 MAPK and p38 MAPK in the stimulation of cytotrophoblast cell motility by EGF., These data support a role for ERK1/2 in a postattachment step, although the precise mechanism remains under investigation., ErbB2 inhibition leads to a persistent phosphorylation of ERK1/2, which negatively regulates the downstream signaling and cell growth, Inhibition of chemotaxis by PPAR-gamma ligands correlated with decreases in extracellular signal-regulated kinase-1 and -2 activation, actin polymerization, and adherence to a fibrinogen substrate., Abnormally high levels of ERK1/2 activity may be involved in endometriosis, possibly by stimulating endometrial cell survival., Inhibition of ERK1/2 and activation of p38 are involved in diallyl disulfide induced apoptosis of leukemia HL-60 cells., ERK1/2 phosphorylation and c-Jun expression were significantly lowered in gastric cancer compared with the non-cancer adjacent tissues., The increase in COX2 expression and the activation of Erk1/2 regulated by Cot are essential for the induction of cell migration., the Gab1-SHP2-ERK1/2 signaling pathway comprises an inhibitory axis for IGF-I-dependent myogenic differentiation., an important interaction between BRCA1 and ERK1/2 in the regulation of cellular response after IR-induced DNA damage in MCF-7 cells., Only the GERD patients without Barrett's esophagus demonstrated an acid-induced increase in ERK1/2 phosphorylation., ERK1/2-mediated Ser-177 phosphorylation has a role in modulating HDV antigenomic RNA replication, possibly through RNAPII regulation, These results identify a novel signaling pathway involving Jak2-dependent Gab2 phosphorylation leading to Erk1/2 activation and cell proliferation in response to granulocyte colony-stimulating factor., In vascular smooth muscle cells shedding of membrane-bound epidermal growth factor (EGF) receptor ligands and activation of the nonreceptor tyrosine kinases Pyk2 and Src contributed to the thrombin-induced ERK1/2 phosphorylation., Histamine-induced Egr-1 expression is dependent on the activation of the H1 receptor, and rapidly and transiently activates PKCdelta, ERK1/2, p38 kinase, and JNK prior to Egr-1 induction., E2, a sex hormone, stimulates MUC5B gene overexpression by interaction with estrogen receptor alpha (ERalpha) and by acting through extracellular signal-regulated kinase 1/2 (ERK1/2)-mitogen-activated protein kinase (MAPK)., These results suggest that the agonist-induced H2R internalization and ERK1/2 activation are partially dynamin-dependent. Furthermore, ERK1/2 activation via H2R is likely dependent of the endocytotic process rather than dynamin itself., Serum induction initially stimulates MKL1 nuclear localization due to a decrease in G-actin levels, but MKL1 is then downregulated by nuclear export due to ERK1/2 phosphorylation., germinating but not resting conidia of A. fumigatus results in interleukin (IL)-8 synthesis that is controlled by phosphatidylinositol 3-kinase, p38 MAPK, and ERK1/2. MyD88 pathway is activated by A. fumigatus and leads to NF-kappaB activation, Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2., DIDS-sensitive Cl- channels play a key role in the Low-density lipoprotein-induced cell proliferation of human aortic smooth muscle cells via the activation of Erk1/2 and PI3K/Akt and the upregulation of Egr-1., The state of activation of components of mTOR, Ras/Raf kinase/ERK, and nuclear factor (NF)-kappaB signal transduction pathways, as well as cell cycle protein analyte correlates in gastric adenocarcinoma cases, was examined., MAPK-containing signaling complexes are positioned on sensitive promoters with their protein substrates to modulate transcription in situ in response to incoming signals, regulation of ERK1/2 by MKP-3 is countered by the complex regulation of MKP-3 by ERK1/2., short-term inhibition of p42/p44 MAPK activity by depletion of kinase with small interfering RNA caused target gene-specific reductions in AR activity, JAK/STAT3 and ERK1/2 signaling activation is involved in leptin-mediated proliferation of renal cell carcinoma Caki-2 cells, IL-17F may be involved in psoriasis via, in part, the activation of ERK1/2 and the induction of IL-8 in keratinocytes, ERalpha-phospho-Ser118 may be important in leiomyoma growth and is possibly phosphorylated by phospho-p44/42 MAPK., Stimulation of ovarian cancer cell growth appears not to involve the activation of the mitogen-activated protein kinases ERK-1 and p38., HMGB1 induced the activation of p38MAPK, ERK1/2 and Akt., these results indicate the importance of C. burnetii modulation of host signaling and demonstrate a critical role for Akt and Erk1/2 in successful intracellular parasitism and maintenance of host cell viability., The characteristic structural features in both the C-helix and the activation loop likely contribute to the basal activity of the mono-phosphorylated ERK1., the enhanced ability of tumor-derived LMP1 to induce and stabilize the c-Fos oncogene can be localized to two amino acids in the C terminus of LMP1, ERK1/2 activation leads to breast cancer cell proliferation and migration via the downstream effectors beta-catenin, cyclin D1, and survivin., Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope., EGF induces uPAR expression via ERK-1/2, AP-1, and NF-kappaB signaling pathways and, in turn, stimulates cell invasiveness in human gastric cancer AGS cells, Proliferative effects of gamma-aminobutyric acid on the gastric cancer cell line are associated with extracellular signal-regulated kinase 1/2 activation., KV11 peptide (from human Apolipoprotein A) suppresses angiogenesis and tumor progression by targeting the c-Src/ERK signaling pathways in VEGF induced cells, Specific phosphorylation events on ERK1/2 integrate differing upstream signals to induce cardiac hypertrophy., elevated expression of activated ERK1/2 may play a role in lung metastasis of salivary adenoid cystic carcinoma., Sphingosine-1-phosphate inhibits high glucose-mediated ERK1/2 action in endothelium through induction of MAP kinase phosphatase-3., Data show that there are both promoter-specific and cell stage-specific roles for the ERK1/2 signaling pathway on 1,25(OH)(2)D(3)-mediated CYP24 gene induction in enterocyte-like Caco-2 cells., Evidence suggesting that SPHK enhances migration of ML-1 cells by an autocrine mechanism and that the S1P-evoked migration is dependent on protein kinase C alpha, ERK1/2, and SPHK., Erlotinib and gefitinib inhibited EGFR and ERK1/2 phosphorylation/activation in all GBMs, irrespective of the antiproliferative response observed., extracellular signal-regulated kinase 1/2 are activated by silibinin, which suppresses growth of human prostate carcinoma PC-3 orthotopic xenograft, MEK1 binds directly to betaarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization, Aldosterone induces collagen synthesis via activation of extracellular signal-regulated kinase 1 and 2 in renal proximal tubules., CIRP enhanced extracellular signal-regulated kinase 1 and 2 (ERK1/2) phosphorylation, and treatment with an MEK inhibitor decreased the proliferation caused by CIRP., nongenomic effects such as Erk1/2 phosphorylation and calcium influx can be initiated from the membrane in Ishikawa cell, and calcium can activate Erk1/2 phosphorylation., crucial implication of PKC-delta, PKC-zeta, ERK-1/2, and p38 in human blood eosinophil migration through extracellular matrix components, MEK1/2 phosphorylates ERK1/2, which phosphorylates Sp1 and AP-1 that in turn bind to their respective binding sites to regulate the expression of human VIL2 in ESCC cells., B(1)R-induced proliferative effects depend on the activity of epidermal growth factor receptor and subsequent ERK1/2 mitogen-activated protein kinases phosphorylation, Increased PRL1 expression results in activation of Src and ERK1/2, which stimulates MMP2 and MMP9 production, leading to increased cell migration and invasion., Data suggest that mechanical signals are transmitted into the nucleus by ERK/JNK signaling pathways and then stimulate collagen type I expression through AP-1 activation in force-exposed human periodontal ligament fibroblasts., the effects of KGF on duct cell proliferation are mediated by the MEK-ERK1/2 pathway, while the KGF-induced cell differentiation is mediated by the PI3K/AKT pathway, only Erk-1 phosphorylation status was found to be correlated with a significantly shorter 5-years DFS in all disease subgroups, ICBP90 might be a pivotal target for the ERK1/2 signaling pathway to control the proliferation of Jurkat T cells., Examine role of extracellular signal-regulated kinase for endothelial progenitor cell dysfunction in coronary artery disease., GDF-9 activated Rb protein (a critical G(1) to S-phase regulator), ERK42/44, and Smad3, elevated pERK expression occurs in urothelial carcinoma in the absence of B-Raf mutations and is not correlated with FGFR3 over-expression, EP2 and EP4 receptor inhibition induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms, Metformin decreases angiogenesis via NF-kappaB and Erk1/2/Erk5 pathways by increasing the antiangiogenic thrombospondin-1., Data show that in the liver of alveolar echinococcosis patients, ERK 1/2 and p38 MAPK were activated and PCNA expression was increased, and that upon exposure to vesicle fluid, c-Jun N-terminal kinase (JNK) was also activated in hepatocytes in vitro., MC5R signals through a PI3K-regulated Akt-independent pathway leading to downstream activation of ERK1/2, Increased expression of phosphorylated ERK1 is associated with gallbladder adenocarcinoma., SGK1 expression during liver regeneration is a part of a signaling pathway that is necessary for enhancing ERK signaling activation through modulating the MEK/ERK complex formation., PI-3 kinase activity is necessary for ERK1/2-induced disruption of mammary epithelial architecture, Caveolin-1 and caveolae play a paradoxical role in regulating VEGF-induced ERK2/1 activation and in vitro angiogenesis, DEP-1 inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases, LFA-1 and CD2 synergize for the Erk1/2 activation in the Natural Killer (NK) cell immunological synapse, Data show that cholesteryl ester formation was dependent on protein kinase zeta/ extracellular signal-related kinase 1/2 (PKCzeta/ERK1/2) activation., Cilostazol protects endothelial cells against lipopolysaccharide-induced apoptosis through ERK1/2- and P38 MAPK-dependent pathways., Endothelin-1 acts primarily via the ETA receptors to induce phosphorylation of ERK1/2 in human aortic smooth muscle cells., Data show that IGFBP-3 is regulated by the PI3-kinase/AKT and MAPK/ERK1/2 pathways., Akt, activated downstream from ERK 1/2, was required for TGF-beta1-induced ZEBRA expression and enabled Smad3, a mediator of TGF-beta1 signaling, to be acetylated by direct interaction with the co-activator CREB-binding protein, OPN enhances angiogenesis directly through PI3K/AKT- and ERK-mediated pathways with VEGF acting as a positive feedback signal., Adiponectin-stimulated CXCL8 release in primary human hepatocytes is regulated by ERK1/ERK2, p38 MAPK, NF-kappaB, and STAT3 signaling pathways., mitochondrial respiration is essential for activation of ERK1/2 and caspase-3 in human eosinophils stimulated with H2O2., The chimeric compound BIM-23A760 is able to exert cytostatic and cytotoxic effects in pituitary tumors, these phenomena being mainly mediated by DR2D and involving ERK1/2 and p38 pathways activation., AT-III directly acts on platelets and suppresses ADP-induced platelet granule secretion due to inhibiting HSP27 phosphorylation via p44/p42 MAPK and p38 MAPK., Data suggest that p42 ERK and p44 ERK activation are involved in RANTES/CCL5 pro-tumoral effects on Huh7 cells., The use of dynasore allowed to confirm the existence of a dynamin-sensitive element that regulates ERK1/2 activation., The results indicate that serum activates Akt and ERK pathways earlier than XIAP expression., activation of ERK1c is mainly mediated by mitogen-activated protein kinase (MAPK)/ERK kinase 1b (MEK1b), which is an alternatively spliced form of MEK1 that was previously considered an inactive kinase, Results demonstrated that the growth inhibition of HEC1A cells by GnRH-I or GnRH-II is involved in the activation of integrin-FAK and ERK1/2 and p38 MAPK pathways., Oligomeric aggregates of Abeta42 are the principal structural form of the peptide that activates ERK/MAPK in SH-SY5Y cells and these effects are mediated by the alpha7 nAChR., D-glucose, but not L-glucose or mannitol, dose-dependently enhanced AHSG promoter activity through activation of the ERK1/2 signaling pathway, Data show that BME induces the activation of c-Jun N-terminal kinases, p38 mitogen-activated protein kinases and extracellular signal-regulated kinases (ERK)1/2., Radial spoke protein 3 is a mammalian protein kinase A-anchoring protein that binds ERK1/2., The inhibitory effect of ERK1/2 upon Cdx2 in colorectal cancer cells is in sharp contrast to its stimulatory effect upon Cdx2 expression in trophectoderm and trophoblast stem cells., abnormal expression of MKP-1 and p-ERK(1/2) probably assists in promoting the development and progression of ovarian carcinoma, S100A4 and bone morphogenetic protein-2 codependently induce vascular smooth muscle cell migration via phospho-extracellular signal-regulated kinase and chloride intracellular channel 4., Results suggest that genistein could inhibit cell growth by inhibiting AKT phosphorylation, ERK1/2 activity and activating p38 MAPK., Data showed that 9 tumor samples had strong expression of P-Akt and 5/9 had P-MAPK, and none of them had EGFR expression., TGFbeta(1) activates EGFR via an H(2)O(2)-dependent mechanism, which subsequently leads to the activation of Erk(1/2)., analysis of a novel mode of modulation of SM gene transcription by ERK1/2 through a direct phosphorylation of myocardin, ERK-1 kinase prevents TNF + cycloheximide induced apoptosis by regulating the intrinsic mitochondrial pathway through different mechanisms in HeLa cells., lithocholic acid induces uPAR expression via Erk-1/2 and AP-1 pathway and, in turn, stimulate invasiveness of human colon cancer cells., Data show that in hypoxic conditions or coexpressed with a constitutively active form of HIF-1alpha, c-Kit mutants activate the Ras/Raf/Mek/Erk pathway, stimulate proliferation and transform melanocytes., Study suggests that functions of ERK1/2 other than its "canonical" kinase activity are also involved in the pathway-mediated growth arrest signaling., Findings demonstrate that interactions between endogenous RSK1 and PKAc in intact cells regulate the ability of cAMP to activate PKA and identify a novel mechanism by which PKA activity is regulated by the Erk1/2 pathway., Detecting intracellular Erk1/2 phosphorylation and IL-2 and IFN-g production, study confirmed that multiple signals, including VLA-4 engagement, are necessary for maximal T-cell activation beyond that induced via the TCR and CD28., Data how that The differential expression of TrkA and TrkB with differentiation of retinoblastoma cells was mediated by extracellular-signal-regulated kinase 1/2 activation., Data show that mutated GPC3 lacking the GPI anchoring domain (sGPC3) significantly inhibited the in vivo growth, blocked Wnt signaling and Erk1/2 and Akt phosphorylation in tumors., Data show that oncogenic level of ERK1/2 phosphorylation appears to be MEK1 and MEK2 dependent in basal condition., Data identify a novel signaling pathway in the endocrine L cell, whereby Cdc42 regulates actin remodeling, activation of the cannonical 1/2-ERK1/2 pathway and PAK1, and GLP-1 secretion in response to insulin., results suggest that ERK(1/2) and JNK are involved in CS-induced biphasic HO-1 expression by a specific regulation of Nrf2/Keap1-Bach1, Data show that LPS acts via ERK1/2/5 signaling pathways to decrease alphaENaC transcription, reducing channel abundance, activity, and transepithelial Na(+) transport in H441 airway epithelial cells., Results highlight PKCdelta as a potential target for therapy of breast cancers with high activity of the ERK1/2 pathway., Stretch activates myometrium via ERK, caldesmon and focal adhesion signaling, In suicide brain, the interaction of MEK1 with ERK1 and ERK2 is increased along with decreased phosphorylation and catalytic activity of ERK1/2., analysis of structural interactions of hERK1 with mitochondria in HeLa cells, Data show that RNA silencing of choline kinase in HeLa cells completely abrogates the high concentration of phosphocholine, which in turn decreases phosphatidylcholine, phosphatidic acid and signaling through the MAPK and PI3K/AKT pathways., This study demonstrated that H. pylori LPS may be a pathogenic factor causing gastric tumors by enhancing cell proliferation and inflammation via the MAPK cascade in gastric epithelial cells., The differential expression of the Mitf 6a/b isoforms is dependent on the MAPKinase signalling, being linked to the activation of MEK1-ERK2, but not to N-RAS/B-RAF mutation status., interaction of RAGE and its ligand S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53 signaling., Data show that melanoma cells expressing B-Raf(V600E) display a reduced C-Raf, ERK1/2 activation and IL-8 secretion responses in human intestinal epithelial cells infected with T. gondii were shown to be MyD88 dependent, Furthermore, colostrum treatment increases the levels of tyrosine phosphorylated proteins and the activated forms of the extracellular signal-regulated kinases 1 and 2 in HaCaT cell line., Data show 5-HT can induce activation of two interrelated signaling pathways, Erk1/2 and PI3K/Akt to induce proliferation, migration, and differentiation., results suggest that PRL-3's roles in motility, invasion, and metastasis in colon cancer are critically controlled by the integrin beta1-ERK1/2-MMP2 signaling, hypoxia switches glucose depletion-induced necrosis to apoptosis and ERK1/2 and PI3K-Akt exert anti-necrotic and pro-apoptotic activities in the cell death, respectively, Results are consistent with the hypothesis that ERK and mTOR signaling interact at multiple levels to regulate tumor growth in vivo, and support the testing of MEK plus mTOR inhibitor combinations in pancreatic cancer patients., bFGF regulates ERK oscillations in premalignant but not malignant JB6 cells, Bcr-Abl represses the expression of RKIP, continuously activates pERK1/2, and suppresses FoxM1 expression, resulting in proliferation of CML cells., Sorafenib inhibits ERK1/2 and MCL-1(L) phosphorylation levels resulting in caspase 3-independent cell death in malignant pleural mesothelioma, These results suggest that in human tracheal smooth muscle cells, activation of MAPKs, NF-kappaB, and p300 are essential for IL-1beta-induced cPLA(2) expression and PGE(2) secretion., Data show that PF-2341066 reduced HGF-stimulated phosphorylation of c-Met in the tyrosine kinase domain as well as phosphorylation of the downstream signaling effectors, Akt and Erks., Report decreased phosphorylation of ERK1/2 following decreased expression of NKG2D in human K562 cells exposed to asbestos., LRRK2 was associated to a small but significant induction of SNCA, which was suppressed by treatment with the selective MAPK/ERK kinase inhibitor U0126., These results refine the minimal sequence for ERK1/2-driven degradation and further define the functional importance of key regions within BIM(EL), highlighting the complexity of this pro-apoptotic protein., DSCs-expressed CD82 up-regulates the expression of TIMP1 in an autocrine manner and inhibits the invasiveness of human first-trimester trophoblast cells partly through the integrinbeta1/MAPK/MAPK3/1 signaling pathway, Data demonstrate that macroautophagy and ERK1/2 phosphorylation serve as protective mechanisms to counteract the antiproliferative effect of proteasome inhibition., CKbeta8- and CKbeta8-1-induced activation of ERK1/2 is mediated by the G(i)/G(o) protein, PLC, and PKCdelta., Chondrosarcoma cell invasion is increased by hypoxia induced expression of CXCR4 and MMP1 and is mediated by HIF-1a and ERK., Results suggest that ERK1/2 signal pathways play an important role in the proliferation of SCC and that the inhibition of this signal pathway may be effective in the treatment of cutaneous SCC., Results describe a cellular model of sustained ERK1/2 activation through Sprouty2, which may provide a mechanistic understanding of self-sustained biological processes in chronic illnesses such as asthma., Restoration of chemosensitivity in ovarian cancer cells in 3-d cultures by inhibition of c-Met was dependent on extracellular signal-regulated kinase (ERK) 1/2 signaling pathways, the pathologic interaction of osteoarthritis chondrocytes and osteoblasts is mediated via the activation of ERK-1/2 phosphorylation and deactivation of p38 phosphorylation, resulting in hypertrophic differentiation, The authors observed that extracellular signal-regulated kinase (ERK) activation promotes viral fusion via ezrin-mediated cytoskeletal rearrangements, whereas AKT1 attenuates fusion by promoting phosphorylation of F protein of Sendai virus., The Ras/ERK pathway at least in part contributes to the maintenance and the acquisition of stem-like hallmarks, although the extent of its contribution is varied in a cell type-specific manner., Data show that ERK1/2 activation is dissociated from nuclear entry, which is a rate limiting step in primary cells and in vivo., Pin1 regulates BPGAP1 function in Rho and Erk signalling, with active Mek2 serving as a novel regulatory scaffold that promotes crosstalk between RhoGAP, Pin1 and Erk in the regulation of cell migration., Data reveal that Pyk2 couples the activation mGluRs to the ERK1/2 mitogen-activated protein kinase pathway even though it attenuates mGluR1-dependent G protein signaling., The effects of ADAM15 on endothelial hyperpermeability and neutrophil transmigration are mediated by intracellular signalling involving Src and ERK1/2 activation., Overexpression of Egr-1 is caused by mutation of p53 and appears to be initiated through activation of the MEK/ERK1/2 signaling cascade by mutant p53., Serum-free medium conditioned by apoptotic endothelial cell increases extracellular signal-regulated kinases 1 and 2 (ERK1/2) activation and inhibits apoptosis., Binding of G-1 compound to GPR30 in PC-3 prostate cancer cells is followed by sustained activation of Erk1/2 and a c-jun/c-fos-dependent upregulation of p21, resulting in the arrest of PC-3 growth at the G(2) phase., This study demonstrated that IL-6 and high glucose synergistically stimulated MMP-1 expression in mononuclear phagocytes via ERK and JNK cascades and c-Jun upregulation., AMPK-mediated PLD1 activation is required for (14)C-glucose uptake through ERK stimulation, Cadmium effects on differentiated intestinal epithelium involve ERK1/2 and p38 cascades and possibly PLC-beta signaling pathways., ERK5 and ERK1/2 kinase cascades play opposing roles in regulating bone marrow-derived multipotent progenitor cell cartilage formation., Data define a new model of integrin beta4-dependent PKB/Akt and ERK1/2 activation demonstrating the keratin filament as a structure necessary in signal transmission., SOCS-3 interferes with the FGF-2 signalling pathway by modulating p44 and p42 phosphorylation in prostate cancer cells., Alternative splicing of human papillomavirus type-16 E6/E6* early mRNA is coupled to EGF signaling via Erk1/2 activation, ERK(1/2) was found to be activated in a sustained way after endocytosis of hepatitis C virus non-enveloped particles, followed by downstream immediate early gene modulation, Matrix metalloproteinase-9 is required for tubular network formation and migration of resistant breast cancer cells MCF-7 through PKC and ERK1/2 signalling pathways., Data demonstrate that ERK2 but not ERK1 signaling is necessary for Ras-induced epithelial-to-mesenchymal transformation (EMT), and that ERK2 but not ERK1 overexpression is sufficient to induce EMT., Hepatitis B virus X protein upregulated the levels of cyclooxygenase-2, 5-lipoxygenase and phosphorylated extracellular signal-regulated protein kinases 1/2 (p-ERK1/2) in liver cells., PED/PEA-15 modulates Coxsackievirus-adenovirus receptor expression and adenoviral entry, by sequestering ERK1/2., These results suggest that in human rheumatoid arthritis synovial fibroblasts, activation of ERK, JNK, AP-1, and NF-kappaB are essential for IL-1beta-induced ICAM-1 expression and leukocyte adhesion., Factor Xa induces tissue factor expression in endothelial cells by P44/42 MAPK and NF-kappaB-dependent pathways., results support the participation of the mitogen-activated protein kinase/extracellular signal-regulated kinase 1 and 2 pathway in the anti-adipogenic effect of angiotensin II on preadipose cells from human omental adipose tissue, In CFTRDeltaF508 cells, the extracellular glutathione levels are decreased, leading to a greater sensitivity to reactive oxygen species, providing an explanation for the hyperactivation of the p38 and ERK MAPKs and increased IL-6 synthesis., regulatory pathway of ABCC6 expression showing that the ERK1/2-HNF4alpha axis has an important role in regulation of the gene, These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression., analysis of expression and activation of ERK1 and ERK2 in human esophageal cancer cell line EC9706, Thymic stromal lymphopoietin induced proinflammatory gene expression in human airway smooth muscle cells involved ERK1/2, p38, and JNK, and STAT3 activation., significantly decreased cell viability and increased apoptosis in human neuroblastoma cell line in association with down-regulation of p-ERK1/2, p-Akt, p-STAT3 survival pathways., Importance of Parp-1, APEX-1 and ERK1/2 catalytic activities in the growth arrest-induced apoD gene expression., Data hypothesize that VEGFR-2 forms a signaling complex with S1P(1) and and protein kinase C-alpha , evoking bidirectional signaling regulating both ERK1/2 phosphorylation and haptotaxis of ML-1 cells., Results strongly suggest that bFGF mediates TSP50 downregulation by ERK1/2 activation, leading to the phosphorylation of Sp1 in this process., SH3GL2 participates in the regulation of apoptosis through the MEK-ERK signal pathway by adjusting EGFR in the laryngeal carcinoma cell line Hep2, M3 muscarinic acetylcholine receptor subtype as being primarily responsible for these transcription factor responses after stimulation with carbachol through activation of the ERK1/2 pathway, AngII has ability to induce CRP expression in endothelial cells through AT(1)-ROS-ERK1/2 and JNK-NF-kappaB signal pathway, which strengthens understanding of the proinflammatory and proathroscerotic actions of AngII., MAPK3 is an important initiating event in Nef-mediated ICAM-1 expression in Nef-expressed cells., Recombinant or microparticle-associated tissue factor stimulate endothelial cell proliferation through activation of the ERK 1/2 pathway, mediated through a novel mechanism requiring the interaction of exogenous TF with cell surface beta1-integrin., Knockdown of ERK1 kinase reduced ATM activation in response to etoposide treatment, and thereby attenuated phosphorylation of the ATM substrates., The EGFR/ERK pathway is activated in high-grade MECs with aggressive behaviour., Tyr251 and Tyr301 of IL-22R1 are required for Shp2 binding and IL-22-induced Erk1/2 activation., FOXO3a is in a constant inactive state due to its cytoplasmic localization, and that neither PI3K/Akt nor extra-signal-regulated kinase-specific inhibition resulted in its nuclear translocation., AC3-33 is a novel member of the secretory family and inhibits Elk1 transcriptional activity via ERK1/2 MAP, Data show that formylpeptides induce sequential activation of AKT, ERK1/2, and PLD, which represents a novel signaling pathway., Iron and UVA increase MMP-1 activity in dermal fibroblasts not only directly through ERK activation but also by an indirect paracrine loop through TNF-alpha released by normal human epidermal keratinocytes., These observations reveal a major role for the Anaplasma phagocytophilum AptA protein, and the host protein, vimentin, in the activation of Erk1/2 during Anaplasma phagocytophilum infection., Data show that blockade of amphiregulin suppressed the activities of EGFR, HER3, and Akt and the expression of amphiregulin itself., Inhibitors of MAPK pathway ERK1/2 or p38 prevent the IL-1{beta}-induced up-regulation of SRP72 autoantigen in Jurkat cells., Data demonstrate a cross-talk between IGF-1R and AT-1R in AT-II and IGF-1-induced Cx43 expression in SV SMCs involving Erk 1/2 and downstream activation of the AP-1 transcription factor., JNK/SAPK and ERK1/2 signals therefore play critical roles in EGF-mediated HUVEC cell angiogenesis., Increased expression of phosphorylated ERK1 is associated with T4 breast carcinoma., Phosphorylation of STIM1 by ERK1/2 modulates store-operated calcium entry., Phosphorylation of ERK1/2 might play an important role on the occurrence and progression of nasal polyps., The results obtained, therefore, rule out the existence of a negative correlation between ERK1/2 activation and MMP2 activity., Results suggest that activated Pak1 regulates colorectal cancer metastasis requiring an ERK-dependent phosphorylation of FAK at Ser-910., p-ERK1/2 is a predictive factor of response to erythropoiesis-stimulating agents in low/int-1 myelodysplastic syndromes., Data indicate that delta-tocotrienol protects mouse bone marrow and human CD34(+) cells from radiation-induced damage through extracellular signal-related kinase activation-associated mammalian target of rapamycin survival pathways., Data illustrate the importance of a coordinated signaling between Src PTKs, ERK1/2, and JNK during pIgR-mediated uptake of pneumococci by host epithelial cells., Data show that S1P4 uses HER2 to regulate extracellular signal regulated kinase-1/2 MDA-MB-453 breast cancer cells., Gene knockdown of ERK1 resulted in relocation of ATR from the nucleoplasm to the nucleolus in response to hydroxyurea, therefore making ATR unavailable to the sites of DNA damage., This study data suggested that SAA activated PPARgamma through extracellular signal-regulated kinase 1/2 (ERK1/2)-dependent COX-2 expression., Human cells from bronchus, intestine, and skin (keratinocytes)showed similar time patterns for the activation of mitogen-activated protein kinases Erk1/2 when treated with carbon nanoparticles., the CCR7/CCL21 signaling pathway leading to T lymphocyte migration on fibronectin is a beta1 integrin-dependent pathway involving transient ERK1/2 phosphorylation, which is modulated by PLCgamma1, These results support a model in which the interaction between sphingosine kinase 1, sphingosine 1-phosphate receptors 1 and/or 3, and ERK-1/2 might drive breast cancer progression, Resveratrol represses YKL-40 expression in vitro; the ERK1/2 pathway is involved in this repression, Data show that he intracellular signal mechanisms behind the effect of cigarette smoke extract involve activation of ERK1/2 and NF-kappaB pathways., Results showed significantly higher levels of ERK1 protein in smokers vs. non-smokers. Analysis revealed a significant relation among the number of cigarettes smoked daily, the Fagerstrom Test for Nicotine Dependence score and the mRNA expression of ERK1., a novel regulatory mechanism by which mitogenic and oncogenic activation of the Ras/MAPK pathway promotes mTOR signaling, Data suggest that loss of PTEN permits CXCR4-mediated functions in prostate cancer cells through the ERK1/2 pathway., Data show that concurrent phosphorylation of cortactin by ERK1/2 and tyrosine kinases enables cells with the ability to regulate actin dynamics., MC1R signaling activated the ERK pathway in normal human melanocytes and melanoma cells through cKIT., MEK-catalysed ERK phosphorylation is necessary but not sufficient for the full nuclear localization response., The silicotic supernatant of alveolar macrophages have promote proliferation of human embryonic lung fibroblasts and activation of ERK1/2., the major calcineurin-dependent event in glucose sensing by ERK1/2 is the activation of B-Raf., Study demonstrates a novel role of the ERK1/2 signaling pathway in promoting myocardium inflammation and dysfunction in coronary microembolization., Both PAR2 and TLR4 activation on SW620 cells can trigger the phosphorylation of ERK1/2, regulate gene expression, and promote the proliferation and migration of cells., Studies suggest that blocking ERK1 and 2, which play critical roles in multi-drug resistance and survival, may be beneficial in combination with chemotherapeutic drugs in the treatment of MMs and other tumors., TbetaRII alone is able to mediate TGFbeta signaling to ERK1/2 without participation of TbetaRI., Results suggest that low magnitude stretch can induce cPLA(2) phosphorylation through the MEK/ERK and PI3K-Akt pathways, independently., These results strongly suggest that NADPH oxidase-derived ROS-mediated activation of p38 and ERK 1/2 is essential for the M. bovis BCG-induced CCL2 production., the PI3K/PAK1/ERK signaling pathway has a role in LPA-stimulated breast cancer cell migration, Glucose and TNF-alpha increased Egr-1 expressionvia ERK1/2 activation in endothelial cells., Data suggest that activated protein C protects endothelial cells by attenuating cell adhesion molecule expression during inflammation, and that APC engages a regulatory crosstalk involving EPCR, ERK1/2, and NF-kappaB that impairs TNF signaling., These results demonstrate that ERK1/2 is needed for the chondrogenic and osteogenic differentiation of mesenchymal stem cells as induced by TGF-beta3 supplementation., G-CSF restores RARalpha recruitment to target gene promoters through the activation of the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway and the subsequent derepression of chromatin., Overall results proved downregulation of ERK1 by ubiquitin proteasomes and suppression of interaction between ERK1 and STAT1 as type I IFN antagonist function of SARS-CoV PLpro., human rhabdomyosarcoma RD cell differentiation is regulated by reciprocal, functional interactions between myostatin, p38 and extracellular regulated kinase signalling pathways, ERK1 and ERK2 are important for human mesenchymal stem cells adipogenic differentiation., Data show that Amot expression is required for proliferation of breast cancer cells in specific microenvironmental contexts that require ERK1/2 signaling., alpha1-adrenoceptors are coupled to ERK1/2 in the human prostate, the Egr-1/GGPPS/Erk1/2 pathway is responsible for insulin resistance during hyperinsulinism, The study identified raptor as a substrate for p44/42 MAPK., Collagen I induces discoidin domain receptor (DDR) 1 expression through DDR2 and a JAK2-ERK1/2-mediated mechanism in primary human lung fibroblasts., Des-gamma-carboxyl prothrombin stimulates HCC growth and promotes HCC metastasis by increasing the activity of MMP-2 and MMP-9 through activation of the ERK1/2 MAPK signalling pathway, The anti-invasive effects of piperine may occur through inhibition of PKCalpha and ERK phosphorylation and reduction of NF-kappaB and AP-1 activation, leading to down-regulation of MMP-9 expression., Ghrelin activated and phosphorylate extracellular signal-regulated protein kinase (ERK)1/2 and Akt., ATP induces HB-EGF synthesis and release by interacting with the P2 purinergic receptor and through p38 and ERK1/2 signaling in response to a challenging environment., The up-regulation of ERK1/2-dependent thymidylate synthase and thymidine phosphorylase can protect human lung cancer cells from cisplatin-induced cytotoxicity., Both MAPK-Erk1/2 and MAPK-p38 participate in IGF-I-induced signaling pathways for progesterone production, while insulin-induced progesterone production requires MAPK-p38, but not MAPK-Erk1/2., MKP3 not only controls the activities of ERK2 and p38alpha but also mediates cross-talk between these two MAPK pathways., ER Ca(2+) release enhances eNOS Ser-635 phosphorylation and function via ERK1/2 activation., capsaicin-mediated IL-6 increase in prostate cancer PC-3 cells is regulated at least in part by TNF-alpha secretion and signaling pathway involving Akt, ERK and PKC-alpha activat, Pretreatment with PD98059, an inhibitor of ERK1/2, significantly decreased LPS-induced TLR2 and SP-A mRNA expression, in glomerular mesangial cells, glucagon-induced [Ca(2+)](i) increases were mediated through the cAMP-PI3K-PKB-MEK-ERK1/2-TRPC6 signaling pathway., Inhibition of the ERK1/2 signalling suppressed the endothelial-like differentiation of immature dendritic cells., Lentiviral depletion of CXCR4 in IEC-6 cells similarly altered ERK1/2 activity and prevented chemokine-stimulated migration, Data show that the deregulated kinase activities identified, which include the mTOR/p70S6K and ERK1/2 pathways, are potential novel molecular targets in MM., IGFBP-3 binds and inactivates Erk1/2, resulting in suppression of Erk1/2 nuclear localization., Results show that silibinin decreased MMP-2, MMP-9, u-PA, p-p38, and p-Erk1/2 expressions in a concentration-dependent manner., Data suggest that sustained inhibition of both EGFR and ERK1/2 leads to significant protection of the cells from IFNgamma-induced apoptosis, indicating important roles for the EGFR tyrosine kinase and ERK1/2 MAP-kinases in regulating A431 cell death., Devised a novel flow cytometric method to quantify the expression of ERalpha, HER2, and the activation of ERK1/2 simultaneously in single cells., the data in this study suggest that the interaction between FVIIa and TF induces PAR2 activation, thereby triggers the ERK1/2 and IkappaB-alpha/NF-kappaB signal transduction pathway to regulate the gene expression of IL-8, TF, and caspase-7, ERK1/2 activation is essential for leukemia inhibitory factor-mediated increases in proliferation and that both STAT3 and ERK1/2 activation are important for the survival of transformed trophoblasts., ERK1/2, rather than NF-kappaB, JNK and p38 MAPK signaling, plays a role in IL-4 induced chemokine activation, ATP-mediated Erk1/2 activation stimulates Shigella captured by filopodia., It is suggested that since nuclear pERK1/2 can be mitogenic, it can serve as a reliable marker for the progression of ovarian cancer, Study demonstrates that subamolide A triggered the mitochondria-dependent apoptotic pathways and p53 and ERK1/2 activation in the human urothelial carcinoma cell line., TGF-beta1 undergo a switch into mesenchymal cells and PI3K/Akt and MAPK/Erk1/2 signaling pathways serve to regulate TGF-beta1-induced epithelial-to-mesenchymal transition of A549 cells., the PKCdelta/ERK/poly(ADP-ribose) polymerase-1 signaling pathway is involved in histamine- or PMA-induced up-regulation of H1R gene expression in HeLa cells, Results provide an important role of CK2 in regulating nuclear ERK activities., ERK1/2 pathway plays an important role in microvibration-induced osteogenesis in BMSC cellular scaffolds, Clusterin induces matrix metalloproteinase-9 expression via ERK1/2 and PI3K/Akt/NF-kappaB pathways in monocytes/macrophages., Data show that siRNA-mediated MR-silencing prevented DHEA-induced extracellular signal-regulated kinase 1/2 phosphorylation and its effects on FoxO1., cAMP induces autophagy via a novel pathway involving ERK, cyclin E and Beclin 1, Data show that Fas-mediate events are mediated by ERK/JNK MAPKs which subsequently activate NF-kappaB for the transcriptional activation of pro-inflammatory mediators, This study defines a novel CCN2/alpha(v)beta(3) integrin/Src/Smad1 axis that contributes to the pro-fibrotic TGF-beta signaling., Oxidized low density lipoprotein induces cyclin A synthesis in a process involving ERK, JNK and NFkappaB, Results suggest a model in which PRL-2 promotes cell migration and invasion through an ERK1/2-dependent signaling pathway., induce ERK1/2 activation via two distinct pathways, one PKC-dependent pathway occurring at a peak time of =2 min and the other matrix metalloproteinase-dependent growth factor receptor transactivation occurring at both early and later time points, Glycosaminoglycans and glucose prevent apoptosis in 4-methylumbelliferone-treated human aortic smooth muscle cells in a process mediated by Toll-like receptor 4, CD44, and PI3K but not by ERK1/2, Functional and molecular interactions between ERK and CHK2 in diffuse large B-cell lymphoma., Data show that HMGN2 inhibited the attachment of bacteria, and then decreased bacteria-induced ERK1/2 activation and actin polymerization, which might contribute to bacterial internalization into T24 cells., Temporal differences in Erk1/2 activity distinguish among combinations of extracellular matrix component, Imbalance in PRA/PRB ratio frequently associated with carcinogenesis might be a direct consequence of disorders in MAPK signaling., Herbal preparation HMC05 disrupts the ERK1/2 signaling pathways to prevent aortic smooth muscle cell migration and proliferation., our results indicate that ERK1/2, Akt, and cav-1 are involved in the regulatory mechanisms of PPAR-mediated protection against HIV-1-induced MMP-9 expression in brain endothelial cells, Data show that overexpression of ErbB2 maintains PDH flux by suppressing PDK4 expression in an Erk-dependent manner., study demonstrates a novel role of the Raf/MEK/ERK pathway in regulating AR expression in certain PCa types and provides an insight into PCa responses to its aberrant activation, activated ERK1/2 interacts with CAR and represses dephosphorylation of Thr-38, providing a cell signal-regulated mechanism for CAR activation., Ca(2+) influx through reverse mode NCX is required for the activation and the targeting of PKCalpha to the plasma membrane, an essential step for VEGF-induced ERK1/2 phosphorylation and downstream EC functions in angiogenesis, Chemokine CXCL12 uses CXCR4 and a signaling core formed by bifunctional Akt, ERK1/2, and mTORC1 proteins to control chemotaxis and survival simultaneously in mature dendritic cells., The ERK_CEBP/beta intracellular signaling is a key inflammatory pathway that links phagocytosis of wear particles to inflammatory gene expression in osteoprogenitors., DUSP9/MKP-4 is a bona fide target of PKA signaling and attenuation of DUSP9/MKP-4 function can mediate cross-talk between the PKA pathway and MAPK signaling through both ERK1/2 and p38alpha in vivo, Phospho-ERK and AKT status, but not KRAS mutation status, are associated with outcomes in rectal cancer treated with chemoradiotherapy, RHAMM/HA interaction regulates fibrosarcoma cell adhesion via the activation of FAK and ERK1/2 signaling pathways, Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF., Study reveals an important role for cav-1 as a negative regulator of MMP-1 gene expression via inhibition of Erk1/2/Ets1 signaling in dermal fibroblasts., Cell death mediated by Vibrio parahaemolyticus type III secretion system 1 is dependent on ERK1/2 MAPK, Overexpression of MUC1 enhances proangiogenic activity of non-small-cell lung cancer cells through activation of Akt and extracellular signal-regulated kinase pathways., The imbalanced expression of MKP-1 and p-ERK(1/2) may play a role in the development of squamous cell carcinoma (SCC) and these two molecules may be new targets for the therapy and prognosis of SCC., Data indicate that both ERK-1 and ERK-2 are involved in the regulation of IL4 gene expression and binding to its promoter., PRL-1 binding to p115 RhoGAP provides a coordinated mechanism underlying ERK1/2 and RhoA activation, Data suggest that DJ-1 upregulates tyrosine hydroxylase expression by activating its transcription factor Nurr1 via the ERK1/2 pathway., Data strongly demonstrate that the small GTPase ARF1 modulates ERK1/2 activation by alpha(2B)-AR and provide the first evidence indicating a novel function for ARF1 in regulating the MAPK signaling pathway., Studies indicate that ERKs stimulate their own dephosphorylation by directly binding to phosphatases, such as MKP-3, and activating them., mp53 disrupts the role of ShcA in balancing the Smad-dependent and -independent signaling activity of TGF-beta and ShcA/ERK signaling is a major pathway regulating the tumor-promoting activity of TGF-beta, Phosphorylation of nPKC-delta results in activation of ERK1/2 kinase and subsequent induction of Egr-1. Subsequently, Egr-1 directly targets NHE2 promoter and promotes NHE2 transcriptional upregulation by interaction with NHE2-PMA response element., A novel TF/FVIIa/MAPK/c-Fos/MMP-7 axis plays an important role in modulating the invasion of colon cancer cells., The inhibition of Id-1 expression by MK615 is mediated via ERK1/2 activation., RSV G interaction with DC- or L-SIGN was shown to stimulate ERK1 and ERK2 phosphorylation, with statistically significant increases relative to mock-infected cells, Identify cadmium as a potent activator of the proinflammatory cytokine IL-8 in lung epithelial cells and reveal the role of an NF-kappaB-independent but Erk1/2-dependent pathway in cadmium-induced lung inflammation., Epidermal growth factor receptor (EGFR)-mediated positive feedback of protein-tyrosine phosphatase epsilon (PTPepsilon) on ERK1/2 and AKT protein pathways is required for survival of human breast cancer cells., Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium., Suggest that in pancreatic ductal carcinoma ERK1 expression correlated to shorter postsurgical recurrence-free and overall survivals., C-peptide increases Na,K-ATPase expression via PKC- and MAP kinase-dependent activation of transcription factor ZEB in human renal tubular cells, Viral O1L protein is required for sustained activation of erk1/ark2 and promotes viral virulence., VEGF-A stimulation of lymphatic endothelial cells leads to the phosphorylation of VEGFR2 (Tyr 951, 1054, 1059, 1175, and 1214) which subsequently triggers PKC dependent phosphorylation of ERK1/2 and PI3-K dependent phosphorylation of Akt., NKCC1 activation occurred through time-dependent increases in protein-protein interaction between ERK1/2 and NKCC1, which were proportional to EGF concentration, Gambogenic acid mediated apoptosis and was involved in the phospho-Erk1/2 and phospho-p38 MAPK proteins expression changes in HepG2 cells., Advanced glycation end products may play an important role in the impairment of diabetic wound healing by upregulating MMP-9 expression in keratinocytes via the RAGE, ERK1/2 and p38 MAPK pathways, and activation of NF-kappaB., Varicella-Zoster virus ORF12 protein triggers phosphorylation of ERK1/2 and inhibits apoptosis., CCL2 might play an important role in regulating the functions of endometrial stromal cells through Akt and MAPK/Erk1/2 signal pathway., Selectively knocking down ERK1 and/or ERK2 killed A375 melanoma cells., Data suggest that HBXIP upregulates CD46, CD55 and CD59 through p-ERK1/2/NF-kappaB signaling to protect breast cancer from complement-dependent cytotoxicity., T-cell antigen receptor (TCR)-mediated Erk activation requires RasGRP1, but not Grb2/Sos., Sunitinib enhances antitumor effects against chemotherapy-resistant bladder cancer through suppression of ERK1/2 phosphorylation., An in vitro kinase assay showed that the direct binding of Clostridium difficile toxin A to ERK1 or ERK2 inhibited their kinase activities., Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling, Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik., We propose that 1a,25(OH)(2)D(3) and Pi act synergistically through FGF23 signaling and ERK1/2 phosphorylation contributing to late hypertrophic events and impaired mineralization in osteoarthritic chondrocytes., EBV-encoded LMP1 upregulates Igkappa 3'enhancer activity and Igkappa expression in nasopharyngeal cancer cells by activating the Ets-1 through ERKs signaling, Muscarinic cholinergic signaling in cervical cancer cells induces cervical cell motility, which requires ERK1/2 activation., miR-483-5p can serve as a tumor suppressor in gliomas, Lead specifically induces dysregulation of iron response element (IRP)1 protein by activating the ERK1/2 signaling pathway, indicating a novel role for IRP1 and the ERK/MAPK pathway in vascular endothelial functions., caspase-3 cleavage of MKP3 down-regulates MKP3 full length and renders active MKP3 fragments, which may participate in novel regulatory pathways controlling the subcellular localization and activation of ERK1/2 during apoptosis., Hh signaling pathway mediates invasion and metastasis of human hepatocellular carcinoma by up-regulating the protein expression of MMP-9 via ERK pathway., This study provides a first model of ERK1 and ERK2 activation and their nuclear shuttling dynamics, revealing a role in the regulation of the efficiency of nuclear signaling., Dehydroepiandrosterone seems to act selectively on osteoblasts via the dominant ER beta receptor, which mediates amplified cell viability through the MAPK signaling pathway involving pERK1/2 and upregulates the production of OPG rather than RANKL., The mu-opioid receptor-induced ERK1/2 phosphorylation was selectively desensitized by 5-HT(1A) receptor activation., Data show that HEK293T cells transfected with estrogen receptor alpha (ERalpha)+/-Galpha(o) revealed that Galpha(o) stimulated phosphorylation of ERK MAP kinases ERK 1/2 and subsequently increased the phosphorylation of ERalpha on serine 118., Data indicate that expression of pokeweed antiviral protein (PAP) activated the ERK1/2 MAPK pathway to a limited extent, resulting in increased phosphorylation of HIV-1 viral p17 matrix protein., Data indicate that specific ERK1/2 inhibitor PD98059 or U0126 blocked cortisol- and mifepristone-induced responses in uterine natural killer (uNK) cells., CAV-1 affected cell growth of lung cancer NCI-H446 cell through the interactions with p-ERK1/2, estrogen receptor and progestin receptor, Dynamin II function is required for EGF-mediated Stat3 activation but not Erk1/2 phosphorylation, B-cell receptor stimulation induced ERK1/2 activation and upregulation of BLIMP1 mRNA expression in B cells, beta1 integrins should sense the stimulation of fluid shear stress and thus activate ERK1/2 through activating of FAK., DcR3 and ERK1/2 play a vital role in the development of gastric cancer, and they may be new markers for indicating the efficiency of gastric cancer treatment in the future., Data show that p38 MAPK, ERK1/2, and COX-2 activation are mediators for the galectin-1-promoted tumor progression and chemoresistance in lung cancer., CCR3 is strongly expressed by ASM cells in vitro and in vivo. Protection against cell death by CCR3 activation is dependent on p42/44 MAPK but does not affect caspase 3 mediated apoptosis., Propionate-stimulated GPR41 strongly coupled to ERK1/2 activation, while the coupling of linoleic acid-activated GPR40 and acetate-activated GPR43 was weaker., constitutive activation of the ERK1 pathway in HER2/ERBB2-transformed cells prevents EGF deprivation-induced FLIPL upregulation and TRAIL resistance., Dermokine-beta impairs ERK signaling through direct binding to GRP78, endogenous IL-1beta play a role in elastin gene upregulation and this upregulation is mediated by the Ras-ERK1/2 pathway in 3D cultures, TEY domain GnRH-induced phosphorylation of ERK is necessary, but not sufficient for the full nuclear localization response., IL-22 up-regulates K17 expression in keratinocytes in a dose-dependent manner through STAT3- and ERK1/2-dependent mechanisms., miR-214 is the regulator of ERK1, whereas ERK2 is regulated by miR-124 and miR-214 in cutaneous squamous cell carcinoma., The mechanism by which Nec-1 sensitizes shikonin-induced apoptosis appears to be the inhibition of RIP1 kinase-dependent phosphorylation of ERK1/2., ischemia/reperfusion inhibited eNOS expression by inactivation of ERK1/2, leading to decreased NO formation through a MKP-3-dependent mechanism in endothelial cells, These data indicate that EGFR and PKC are involved in mAChR-mediated activation of ERK1/2 and RSK and the subsequent proliferation of SNU-407 colon cancer cells., The level of ERK1/2 phosphorylation was higher in alcoholic liver cirrhosis peritoneal macrophages at baseline than in hepatitis C patients., ERK1/2 have roles in the pathogenesis of GA, a late stage of age-related macular degeneration, Data show that IL-17RA, IL-17RC, IL-22R1, ERK1/2 MAPK and NF-kappaB pathways are involved in Th17 cytokine-induced proliferation., Transgenic ERK2 plays a predominant and/or specific role in pain plasticity, while the contribution of ERK1 transgene is limited., the presence of the G2019S LRRK2 mutation, one of the most prevalent in LRRK2, is accompanied by a deregulation of autophagy basal levels dependent on the MAPK1/3 (ERK2/1) pathway., Aortic endothelial cells stimulated with HLA class I antibodies did not promote any detectable change in intracellular Ca(2+) concentration but instead induced MLC phosphorylation and stress fiber assembly., ERK-1 and 2 can modulate MMP2 and 9 and are essential for the induction of abdominal aortic aneurysm., CCL2/CCR2 chemokine signaling coordinates survival and motility of breast cancer cells through Smad3 protein- and p42/44 mitogen-activated protein kinase (MAPK)-dependent mechanisms., osteosarcoma patients whose tumors expressed pERK1 had a poorer clinical outcome than those whose tumors did not., Nampt has a key role for overcoming multiple myeloma drug resistance and its signal transduction-targeted pathways (mTORC1, ERK1/2)., CXCL12/CXCR4 protein signaling axis induces sonic hedgehog expression in pancreatic cancer cells via extracellular regulated kinase- and Akt kinase-mediated activation of nuclear factor kappaB, Data show a link between the ERK1/2 pathway and BIM expression through miR-494., Data indicate that OCT4A interacts with ERK1/2 and is phosphorylated at Ser-111, increasing its ubiquitination and degradation., SHOC2 and CRAF mediate ERK1/2 reactivation in mutant NRAS-mediated resistance to RAF inhibitor., The balance between Bax and Mcl-1 protein expression, and theinvolvement of p38MAPK and ERK1/2 signaling pathways in the control of Mcl-1 expression were investigated in obstructive sleep apnea patients undergoing nightly intermittent hypoxia episodes., ERK reduces NHEJ-mediated repair of double strand breaks via attenuation of DNA-PKcs activation., ERK1/2 signaling plays an important role in topoisomerase II poison-induced G2/M checkpoint activation., After transfection of HUVECs with miR-155, expression of apoptosis-promoting factors and ERK1/2 phosphorylation were reduced significantly and HUVEC migration and capillary tubule formation were restored to some extent., A previously unrecognized interplay between ERK1/2, TWIST1, and MMP-1 that is likely significant in the progression of melanoma toward metastasis., Vitamin D significantly reduced the endothelial malfunction and damage caused by oxidative stress, through the activation of MEKs/ERKs/SirT-1 axis., TNF-alpha stimulates tissue repair functions of HPAECs. This may be mediated, at least in part, positively via JNK & ERK1/2. This may play a role in endothelial cell-mediated tissue repair, especially in an inflammatory milieu where TNF-alpha is present., Data indicate that patients with high tumour levels of pMAPK and pER(ser118) expression had a significantly shorter disease-free survival time in comparison to those with low pMAPK and pER(ser118) expression., Data indicate that tocilizumab enhanced the interferon-induced phosphorylation of STAT1 and inhibited SOCS3 expression and the phosphorylation of both STAT3 and ERK., Derlin-1 is overexpressed in non-small cell lung cancer and promotes invasion by EGFR-ERK-mediated up-regulation of MMP-2 and MMP-9., MRK is a novel RhoC effector that controls LPA-stimulated cell invasion at least in part by regulating myosin dynamics, ERK and p38, P38 indirectly promotes apoptosis via ERK1/2 inhibition but directly causes coxsackievirus B3-induced necrosis., VEGFR2 internalization may be a generic requirement for pro-angiogenic growth factors to activate endothelial ERK1/2 signaling, Data indicate that besides confirming the constant presence of BRAF-V600E in all patients with hairy cell leukemia, phospho-ERK1/ERK2 expression was observed., We conclude that pERK1/2 is a sensitive marker of early colon cancer, which disappears at later stages of cancer development., Data indicate that upon U0126 treatment, Erk1/2 activities were greatly diminished in colorectal cancer cell lysates., Extracellular signal-regulated kinase and glycogen synthase kinase 3beta regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism, hCGbeta induced cell motility via promoting ERK1/2 phosphorylation and MMP-2 upregulation in human prostate cancer DU145 cells., Data indicate that the MEK-ERK signaling pathway contributes the maintenance of the immature state of monocyte-derived dendritic cells (MDDCs) is partly dependent on the activity of aryl hydrocarbon receptor (AhR)., in human neutrophils, ERK1/2 kinase is not directly involved in the regulation of iNOS and NO production induced by NDMA; however, the kinase participates in superoxide anion production in these cells, Activated/phosphorylated pMAPK 44/42 was detected in 82% of medulloblastomas, all subtypes, and in 62.5% of primitive neuroectodermal tumors with coexpression of SSR1 in one third., ERK1/2 signals downstream of C/EBPbeta to facilitate IL-1beta-induced astrocyte TIMP-1 expression., Obesity-induced insulin resistance in human skeletal muscle is characterised by defective activation of p42/p44 MAP kinase., GLIPR-2 overexpression in HK-2 cells can potentiate EMT-like processes in this cell type through the ERK1/2 signaling pathway, hyperactivated ERK and/or AKT signaling pathways promoted MED1 overexpression in prostate cancer cells., ERK2 but not ERK1 is shown to be responsible for paxillin serine 126 phosphorylation and its increased turnover at focal adhesions., Simvastatin-treated patients with abdominal aortic aneurysms exert lower CyPA mRNA/protein levels and a decreased amount of phospho-ERK1/2., ERK1/2 activity may protect pancreatic cancer cells from chemotherapy-induced apoptosis., studies show that SAP97 interactions with CRFR1 attenuate CRFR1 endocytosis and that SAP97 is involved in coupling G protein-coupled receptors to the activation of the ERK1/2 signaling pathway., Data suggest that angiotensin II AT1 receptor (AT1R) may be an important transducer of shear stress-dependent activation of ERK1/2., Interference with ERK(Thr188) phosphorylation permits the impairment of ERK1/2-mediated cardiac hypertrophy without increasing cardiomyocyte death., 5-HT inhibits pulmonary artery smooth muscle cell apoptosis via pERK1/2, PDK, 5-HT1B, 5-HTT pathway., Data indicate that fucoxanthin and siphonaxanthin down-regulate the phosphorylation of FGF-2-mediated intracellular signaling proteins ERK1/2 and Akt., results suggest that c-Src suppression by PP2 or siRNAs may regulate the progression of cell cycle through AKT/GSK3beta and ERK1/2 pathways, Data indicate CCN1 can induce actin reorganization, formation of lamellipodia, and cell migration/invasion through the alphaV integrins/Rac1/ERK signaling axis; these CCN1-dependent activities can be effectively suppressed by monoclonal antibody YM1B., activation of the MEK-ERK pathway contributed to EGFR-facilitated prostate cancer stem-like cell propagation., IL-31 induces pro-inflammatory effects in activated human macrophages via STAT-1 and 5 phosphorylation. Interleukin-31-induced ERK 1/2 activation contributes to the underlying mechanism of Th1 cytokine IL-12 suppression in macrophages., POPX2 might regulate cell motility through its regulation of the MAPK1/3, leading to changes in the cytoskeleton and cell motility., Elevated Notch1 levels and enhanced Notch1 activation play a major role in augmentation of the pro-osteogenic response of aortic valve interstitial cells of stenotic valves through modulation of ERK1/2 and nuclear factor-kappaB activation., Data show that macrophages on gastric and colorectal cancer cells migration through epidermal growth factor receptor and phosphorylation of Akt, c-Src and ERK1/2, and led to an increase of RhoA and Cdc42 activity., Data indicate that expression of mutant TRPC6 induces ERK1/2 activation via both cell-autonomous and non-cell-autonomous mechanisms., ERK1 localized to the cytosol and translocated to the nucleus upon cell activation and kinase phosphorylation., Data show that curcumin-loaded polyvinylpyrrolidone nanoparticles (CURN) decreased the expression of ICAM-1, inhibited NADPH oxidase (NOX)-derived ROS generation, and reduced MAPKs and AP-1 transcription factor binding activities., Findings suggest that IL-6 promotes the maturation of autophagosomes into functional autolysosomes by regulating ERK., In activated eosinophils ligation of Siglec-8 leads to ROS-dependent enhancement of IL-5-induced ERK phosphorylation, which results in a novel mode of biochemically regulated eosinophil cell death., Data show that hepatitis C virus NS5A-transactivated protein 9 (NS5ATP9) knockdown activated mitogen-activated protein kinase kinase/extracellular signal regulated kinases 1/2 signaling under C virus nonstructural protein 5A (NS5A) expression., miR-21 promoted the proliferation, migration and inhibited apoptosis of Eca109 cells through activating ERK1/2/MAPK pathway., A novel, time-dependent change in the relationship between total ERK and phosphorylated ERK levels that persists without negative feedback, is reported., results suggest that ERK1/2 regulates SIRT2 by increasing the protein levels, stability and activity of SIRT2, CAC1 promoted the proliferation of human lung cancer A549 cells with activation of ERK1/2 signaling pathways., Data indicate that Erk1/2 and Akt activation were increased in CCA tissues when compared with their normal adjacent tissue., DUSP4 attenuates ERK signaling and reduces cell viability, suggesting that the novel crosstalk between NFkappaB and mitogen activated protein kinase pathways contributes to cell survival., ERK signal is potentially a mediator in the process of osteogenic differentiation of human mesenchymal stem cells induced by phosphatidylserine., results identify STYX as an important regulator of ERK1/2 signaling critical for cell migration, Female stress urinary incontinence is associated with reduced expression levels of phosphorylated ERK1 and ERK2 as compared to controls., Expression of TMPRSS4 in gastric cancer is significantly associated with lymph node and distant metastasis, high Erk1 expression, and poor prognosis., Data suggest that ERK1/2 (MAPK3/MAPK1) signaling pathway acts as a potent negative regulator of expression of placental/trophoblastic HSD11B2 (11-beta-hydroxysteroid dehydrogenase type 2); such inactivation involves transcriptional regulation., Adiponectin inhibits neutrophil apoptosis via activation of AMP kinase, PKB and ERK 1/2 MAP kinase., Data show that buthionine sulfoximine and synergizes with hydroxychavicol in inducing apoptosis of chronic myeloid leukemic (CML) cells through the GSH-ROS-JNK-ERK-iNOS pathway by apoptosis inducing factor (AIF)-dependent manner., Data suggest opposing paths of blocking apoptosis of placental trophoblasts infected with Toxoplasma gondii strains differing in virulence is due to different cytokine secretion profile and expression of Fas/CD95 antigen and phosphorylated ERK1/2., The combined expression of Cav-1 and pERK serves as an independent biomarker signature with potential merit in renal cell carcinoma surveillance strategies., TNF-alpha modulation of intestinal epithelial tight junction barrier is regulated by ERK1/2 activation of Elk-1., Trib1 acts as an activator of the MAPK pathway., Findings indicate that phosphatidic acid (PA) production by PLD2 determines the output of ERK1/2 in cancer cell growth factor signaling., nuclear phosphorylated ERK1/2 is associated with enhanced proliferation and invasion of mammary carcinomas, Data indicate that the median time to progression (TTP) 8.9 months is close to the promising BRAF- and MEKi combination therapy with median progression-free survival (PFS) 9.4 months., After MeCP2 siRNA treatment, p-ERK1/2 levels decreased, but p-p38 levels increased., ERK1 and ERK2 kinases are positively regulated by GLIPR-2., ERK, AKT, and GSK-3beta have roles in boldine-induced cell cycle arrest and apoptosis in T24 human bladder cancer cell line, Results indicate that mitochondrial dysfunction resulting from changes in the ERK1/2-fission/fusion dynamin-like protein (DLP1) machinery and signaling pathway., ERK1 phosphorylates KIBRA at Ser(548) for cell proliferation and migratory activity, Airborne particulate matter exposure induced cytoplasmic p21(CIP1/WAF1) retention, ERK1/2 activation, cytoskeleton remodeling and the acquisition of a senescence-like phenotype in lung cells., results demonstrated that p38 and ERK1/2 played crucial positive roles in adipogenesis, and FAK, RhoA/ROCK and cytoskeleton played negative roles, activation of deltaPKC increased its binding to 14-3-3, transiently activated ERK1/2 and increased ESC proliferation., pERK 1/2 inhibit Caspase-8 induced apoptosis in cancer cells by phosphorylating it in a cell cycle specific manner., Endogenous or exogenous PGD2 induces CRTH2-dependent apoptosis in human differentiated osteoclasts; beta-arrestin-1, ERK1/2, and Akt, but not IKK2/NF-kappaB are probably implicated in the signaling pathways., Ghrelin promotes intestinal epithelial cell proliferation through PI3K/Akt pathway and EGFR trans-activation both converging to ERK 1/2 phosphorylation., Nodal expression was significantly upregulated in glioma cells when TGF-beta was added, whereas the TGF-beta-induced Nodal expression was evidently inhibited by transfection Smad2 or Smad3 siRNAs., These findings reveal a novel, differential responsiveness of PP5-ERK1 and PP5-ERK2 interactions to select oncogenic Ras variants and also support a role for PP5.ERK complexes in regulating the feedback phosphorylation of PP5-associated Raf1., Gli1 inhibited cell growth, cell cycle progression and induced apoptosis and autophagy depending on ERK1/2 activity in chondrosarcoma cells., Data indicate that quercetin inhibited the interaction between IQ motif-containing GTPase activating protein 1 (IQGAP1) and extracellular signal-regulated kinases ERK1/2 in RPMI8226 multiple myeloma cells., Data show that sangivamycin induced the apoptosis of primary effusion lymphoma (PEL) cells by activating caspase-7 and -9 and suppressed the phosphorylation of Erk1/2 and Akt, thus inhibiting activation of the proteins., IQGAP1 expression in podocyte under high glucose media is modulated by the ERK1/2 pathway., our data emphasizes the importance of the translational regulation of p21 by the MEK1/2-ERK1/2-p70S6K pathway to negatively control the cell cycle progression., Tissue kallikrein facilitated the activation of EGFR, ERK1/2 and p38 cascade. Not p38 but ERK1/2 phosphorylation was severely compromised in cells depleted of EGFR. Impairment of signaling of ERK1/2 seemed not to be restricted to EGFR phosphorylation., There are comparable levels of EESR1, total ERK1/2 and active ERK1/2 in the stroma and epithelium of proliferative phase endometrium., Data indicate that sulforaphane (SFN) inhibited invasion via activating extracellular signal-regulated kinases ERK1/2 in a sustained way., distinct p38/ERK pathways are related to E-cadherin levels and function downstream of E-cadherin allowing, respectively, for hepatocyte-mediated MErT and tumor cell survival in the face of death signals., The present experiments demonstrated a critical role for the GPRC6A-ERK1/2 and PI3K/Akt signaling pathway in arginine-mediated fibroblast survival., These results first declare that MAPK-PPARalpha/gamma reciprocal signal pathways are involved in Chlamydia pneumoniae, which induces foam cell formation, thus facilitating atherogenesis., Activation of GABAB receptor promotes breast cancer cell metastasis by enhancing p-ERK1/2 levels., CD99 induces ERK activation, increasing its membrane-bound/cytoplasmic form rather than affecting its nuclear localization., Enhanced t-ERK1 expression in infiltrating lymphoid cells was significantly associated with female gender, absence of vascular and perineural invasion, lymph node metastases and early depth of invasion as well as with longer disease-free survival times, Paxillin-GEF-H1-p42/44-MAPK module as a regulator of pathological mechanotransduction., HGFs modulate IL-10 production in monocytes through the ERK1/2 pathway., ERK1/2 as well as STAT3 (Ser727) phosphorylation play an important role in LIF-mediated JEG-3 trophoblastic cell invasion and gene expression, These data disclose a novel mechanism by which ERK1/2 regulates mitochondrial function through direct phosphorylation of TFAM., Data show that salvianolic acid B protects endothelial progenitor cells against oxidative stress by modulating Akt/mTOR/4EBP1, p38 MAPK/ATF2, and ERK1/2 signaling pathways., Data suggest that extracellular signal-regulated kinases ERK1/2 signaling can cross-interact with the transforming growth factor beta2/Smad2/3 and the Jagged-1/Notch-3 signaling in retinal pigment epithelium cells epithelial-mesenchymal transition., Results demonstrate that overexpression of p-ERK1/2 is closely associated with metastasis in gastric adenocarcinoma., Insulin-induced apoptotic commitment depended on the down-regulation of Erk-1, insulin growth factor-1 receptor (IGF-1R), and fibroblast growth factor receptor-1 (FGFR-1)-mediated signaling., Rg3 exhibits anti-leukemia effect in part due to its anti-angiogenic activity via inhibiting PI3K/Akt and ERK1/2 pathways, which act to regulate the expression of HIF-1alpha and VEGF., Report EGFR overexpression and ERK1/2 overexpression in Kazakh patients with esophageal squamous cell carcinoma., ATR1-blockade-induced reduction in cytokine levels in the atheroma supernatant correlated to a reduction in ERK1/2 expression in the tissue. Inhibition of ERK1/2 downregulated IL-6, IL-8 and CXCL5 in both atheroma and cell culture supernatants., This study identified and confirmed MAPK3 protein changes within the postsynaptic density in schizophrenia, Low ERK1 expression is associated with hormone resistance in breast cancer., proliferation was linked to a novel DEPDC1B-Rac1-ERK1/2 signaling axis in oral cancer cell lines., Data indicate that the mRNA and protein expressions of extracellular signal-regulated kinase 1/2 (ERK1/2) and and matrix metalloproteinases MMP-2 and MMP-9 were significantly decreased by baicalein., Shock wave treatment induced ATP release, increased Erk1/2 and p38 MAPK activation, and enhanced proliferation in three different cell types, increased AQP8, Erk1/2 and phosphorylated-Erk1/2 expression may play a role in transformation of cervical intraepithelila neoplasia into cervical cancer, and in early invasion and lymphatic metastasis of cervical cancer, PTN decreased melanogenesis, probably through MITF degradation via Erk1/2 activation in melanocytes., miR-155 plays an important role in regulating the pathological network involving EMT process and ERK1 pathway during hepatic stellate cell activation., Immunohistochemistry analyses show that the cell signalling proteins AKT1 and ERK1/2 shuffled from the nucleus to the cytoplasm with tumour progression in breast cancer., ERK1/2 signal induced MNK catalytic activity enabled enterovirus type 1 internal ribosomal entry site-mediated translation/host cell cytotoxicity through negative regulation of the Ser/Arg (SR)-rich protein kinase (SRPK)., Sphingosine-1-phosphate promotes extravillous trophoblast cell invasion by activating MEK/ERK/MMP-2 signaling pathways via S1P/S1PR1 axis activation., ERK1/2 constitutively phosphorylated tumour cells was able to markedly decrease the number of double minute chrom, Data show that ouabain-induced glioblastoma cells apoptosis and increased reactive oxygen species (ROS) generation in extracellular signal-related kinases ERK1/2-Shc signaling adaptor protein p66SHC-dependent pathway., ERK1 and ERK2 activation plays a decisive role in yellow fever virus replication., alkaline phosphatase plays a role in the ERK1 and ERK2 dephosphorylation in renal cell carcinoma cell lines., Gastrin stimulates proliferation of HT-29 cells and inhibits apoptosis by upregulating phosphorylation of ERK and K-ras through the Ras-Raf-MEK1/2-ERK1/2 pathway., Episesamin interferes with inflammation-associated smooth muscle cell activation and subsequent decreased proliferation and migration via ERK1/1 signaling., Therefore, our study demonstrates that MAPK members (ERK1/2 and JNK) play a key role in CCR7 regulating SCCHN metastasis, The fact that phospho-Erk1/2 is a common element to both mechanisms suggests that specific factors deciding between proliferation and apoptosis must be operative downstream of this signaling pathway., SKLB-M8 inhibited HUVEC proliferation, migration, invasion, and tube formation in vitro with the inhibition of phosphorylated ERK1/2., An increase in integrin-linked kinase non-canonically confers NF-kappaB-mediated growth advantages to gastric cancer cells by activating ERK1/2, These results therefore indicate that p53-mediated up-regulation of MKP-3 contributes to the establishment of the senescent cellular phenotype through dephosphorylating ERK1/2, High phosphorylated ERK1 is associated with low response to chemotherapy in nonsmall-cell lung carcinoma., Data indicate that the interferon regulatory factor (IRF1) promotion was observed in cancer cell lines treated with different MEK inhibitors or with RNAi oligonucleotides against extracellular signal-regulated kinases (ERK1/2)., PBX3 induces invasion and metastasis of colorectal caner cells partially through activation of the MAPK/ERK signaling pathway., Therefore, the positivity of p-ERK1/2 expression may serve as a vital biomarker in the development of non-small cell lung cancer, CD44 functions as an upstream regulator sensing the extracellular environment to modulate ERK, AKT and Hippo-YAP pathways which cooperatively control downstream gene expression to modulate breast cancer cell contact inhibition of proliferation., Results show that miR-483-5p expression level is up-regulated in polycystic ovary syndrome patients and inversely correlated with notch3 and MAPk3 levels and that Notch3 and MAPK3 are the direct targets of MIR483., ERK1 and ERK2 promoted proliferation and inhibited apoptosis of human cervical cancer cells and regulated the expression of c-Fos and c-Jun proteins., Data indicate that microRNA miR218-5p negatively regulates trefoil factor 1 (TFF1) in an extracellular signal-regulated kinases Erk1/2-dependent manner., IL-33 promotes gastric cancer cell invasion and migration by stimulating the secretion of MMP-3 and IL-6 via ST2-ERK1/2 pathway., Letter, Cigarette smoke decreases CFTR expression in the lung via MEK/ERK1/2 MAPK pathway., Data indicate that cyclic AMP signaling reduces the expression of sirtuin 6 deacetylase via inhibition of the c-Raf-MEK1-ERK1/2 pathway., The results of our study suggest that ERK1 and ERK2 have previously unrecognized effects on the Hippo pathway in human non-small cell lung cancer cells, overexpression or knockdown of PTK6 or ERK1/2 effectively removed the inhibition of S1P-induced migration by miR-17., inhibition of NCX1 by KB-R7943 in Madin-Darby canine kidney cells, LLC-PK1, and human primary renal epithelial cells (HREpiC) increased ERK1/2 activation and cell migration., these results suggest that M. tuberculosis Mce3E exploits the ERK1/2 signaling pathway to suppress host innate immune responses, providing a potential Mce3E-ERK1/2 interface-based drug target against M. tuberculosis., Data show that phosphoprotein enriched in astrocytes of 15 kDa (PEA-15) influences dephosphorylation of epidermal growth factor receptor (EGFR) via extracellular signal-regulated kinases ERK1/2 sequestration in the cytoplasm., Taken together, this study for the first time identified both ERK1 and ERK2 were required for enterovirus 71 efficient replication., p44/42, a known apoptosis-promoting regulator and caspase 3 activator, was increased in brain tumor cells treated with violacein, data demonstrate that HNP-1 induces IL-8 production not only through P2Y6, but also through additional P2 receptors via an ERK1/2-dependent mechanism in intestinal epithelial cells., In several leukemia cell lines, U0126 suppressed the basal phosphorylation levels of p44/42 ERK in a dose-dependent manner and this restored AMPK activation after metformin treatment., In several melanoma cell lines, DMU-212 activated the ERK1/2 pathway, increasing the phosphorylation of ERK 1 and 2 and their translocation to the nucleus. This ultimatedly resulted in G2/M arrest., Peroxisome proliferator-activated receptor gamma attenuates serotonin-induced pulmonary artery smooth muscle cell proliferation and apoptosis inhibition involving ERK1/2 pathway., the relative mRNA copy values of KSR1, ERK1 and ERK2 in the cancer tissues were 2.43 +/- 0.49, 2.10 +/- 0.44 and 3.65 +/- 0.94..EGb 761 enhanced the chemotherapy sensitivity through suppression of the KSR1-mediated ERK1/2 pathway in gastric cancer, Rich1 negatively regulates the epithelial cell cycle, proliferation and adhesion by CDC42/RAC1-PAK1-Erk1/2 pathway., 3D topography transiently induces concomitant upregulation of IL-1beta and MAPK ERK1/2 through nuclear factor-kappaB-dependent signaling pathway., TPP2 mediates many important cellular functions by controlling ERK1 and ERK2 phosphorylation., immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes, rapamycin inhibits Cd activation of Erk1/2-mediated neuronal apoptosis through intervening mTOR-PP2A/PTEN signaling network, Disruption of beta-catenin binding to parathyroid hormone (PTH) receptor PTH1R inhibits PTH-stimulated ERK1/2 activation., Dienogest treatment of endometriotic cells suppresses AKT and ERK1/2 activity, thereby in turn inhibiting mTOR, inducing autophagy, and promoting apoptosis., CD40 signaling led to sustained ERK1/2 activation and up-regulation of Bcl-xL in BCR-primed HF1A3 germinal center B cells., Tamoxifen prevents TGF-beta1 mediated myofibroblast differentiation through ERK1/2 signaling pathway., P2Y2 receptor and EGFR cooperate to promote prostate cancer cell invasion via ERK1/2 pathway., It was shown that newly synthesized H2O2 invigorates the phosphorylation and action of ERK-1/Erk2 in E. coli phagocytosis, while phospho-JNK and phospho-p38 appear to regulate H2O2 production., Opioid receptor delta-mediated activation of ERK1/2 is via ligand-specific transactivation of EGFR., Case Report, Data point to a nongenomic mechanism of action of parabens in activation GPR30 in both cancer and non-cancer breast cell lines through betagamma dimer-mediated activation of the ERK1/2 pathway, but not the cAMP/PKA pathway., Inhibition of snail expression and quercetin suppressive renal carcinoma by altering AKT/mTOR/ERK1/2 signaling pathways., CXCR4 inhibitor attenuates allergen-induced lung inflammation by down-regulating MMP-9 and ERK1/2 expression., Over-expressed TWIST associates with markers of epithelial mesenchymal transition and predicts poor prognosis in breast cancers via ERK and AKT activation., GPCR cell-surface expression is regulated by receptor sequestration in response to beta-arrestin-2 phosphorylation by ERK1/2, HRG could inhibit hepatocellular carcinoma cell proliferation via the FGF-Erk1/2 signaling pathway by reducing Erk1/2 phosphorylation., Study highlights the potential role of CCM3 in regulating tight junction complex organization and brain endothelial barrier permeability through CCM3-ERK1/2-cortactin cross-talk, /2 activities are required for not only MII-arrest maintenance, but also efficient pronuclear formation in mouse oocytes, Letter, Data indicate that the activation of extracellular-regulated protein kinase (ERK)1/2 as a downstream signal in the mitogenactivated protein kinase (MAPK) pathway during cytokine production and apoptosis., Suggest that EGFR/ERK1/2 signaling pathway but not cholinergic pathway involved in chlorpyrifos-induced colorectal adenocarcinoma cell growth., results demonstrate that PSMC5 is a new and important player involved in regulating ERK1/2 signal transmission through the remodeling of Shoc2 scaffold complex in a spatially-defined manner., The presented data demonstrate that propranolol, via betaAR perturbation, dose dependently suppresses cAMP levels and activated extracellular signal-regulated kinase 1/2., Thus, this study demonstrated effective chemotherapeutic potential of SFE by inducing apoptisis as well as inhibiting migration and their preliminary mechanism for human gastric cancer management., MicroRNA-133b inhibits proliferation and invasion of ovarian cancer cells by inactivating Akt and Erk1/2 signaling and targeting EGFR., In summary, this study identified a novel role for EGFRvIII in hypoxia tolerance, supporting an important link between hypoxia and subcellular localization alterations of the receptor., Endocytosis separates EGF receptors from endogenous fluorescently labeled HRas and diminishes receptor signaling to MAP kinases in endosomes., FXa inhibitor reduces the collagen-stimulated release of phosphorylated HSP27 from human platelets due to the inhibition of HSP27 phosphorylation via p44/p42 MAP kinase, Studies indicate key feedback loops involved in the cross-talk among the insulin-proto-oncogene protein c-akt (AKT) and MAPK/ERK signaling pathways., The Asian-American variant of human papillomavirus type 16 exhibits higher activation of MAPK and PI3K/AKT signaling pathways, transformation, migration and invasion of primary human keratinocytes.,
OFFICIAL_GENE_SYMBOL MAPK3,
SP_COMMENT catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases., enzyme regulation:Activated by tyrosine phosphorylation in response to insulin and NGF., function:Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4)., PTM:Dually phosphorylated on Thr-202 and Tyr-204, which activates the enzyme., similarity:Belongs to the protein kinase superfamily., similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily., similarity:Contains 1 protein kinase domain., subunit:Interacts with MORG1 (By similarity). Binds to HIV-1 Nef. This interaction inhibits its kinase activity. Interacts with HSF4 and NISCH.,