Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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protein kinase cAMP-activated catalytic subunit gamma(PRKACG) protein kinase cAMP-activated catalytic subunit gamma(PRKACG) Related Genes Homo sapiens
CHROMOSOME 9,
CYTOBAND 9q13,
ENSEMBL_GENE_ID ENSG00000165059,
GENERIF_SUMMARY PKA-mediated phosphorylation of GPIbbeta at Ser(166) negatively regulates VWF binding to GPIb-IX and is one of the mechanisms by which PKA mediates platelet inhibition, Results suggest that Cgamma and Calpha differ in structure and function in vitro, supporting the hypothesis that functionally different C-subunit isozymes could affect cAMP signal transduction downstream of protein kinase A activation., In human primary pigmented nodular adrenocortical disease tissues, dexamethasone paradoxically stimulates cortisol release through a glucocorticoid receptor-mediated effect on PKA catalytic subunits., Findings show that PKIB and PKA-C kinase can have critical functions of aggressive phenotype of PCs through Akt phosphorylation and that they should be a promising molecular target for PC treatment., Results suggest that PKA can negatively regulate ERalpha, at least in part, through FoxH1., The missense p.74Ile>Met PRKACG mutation is associated with a marked defect in proplatelet formation and a low level in filamin A in megakaryocytes.,
OMIM_DISEASE Bleeding disorder, platelet-type, 19,
SP_COMMENT catalytic activity:ATP + a protein = ADP + a phosphoprotein., enzyme regulation:Activated by cAMP., function:Phosphorylates a large number of substrates in the cytoplasm and the nucleus., similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily., similarity:Contains 1 AGC-kinase C-terminal domain., similarity:Contains 1 protein kinase domain., subunit:A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits., tissue specificity:Testis specific. But important tissues such as brain and ovary have not been analyzed for the content of transcript.,