Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
The Database for Annotation, Visualization and Integrated Discovery
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protein phosphatase 1 regulatory subunit 12C(PPP1R12C) protein phosphatase 1 regulatory subunit 12C(PPP1R12C) Related Genes Homo sapiens
CHROMOSOME 19,
CYTOBAND 19q13.42,
ENSEMBL_GENE_ID ENSG00000125503,
GENERIF_SUMMARY M-RIP can assemble a complex containing both RhoA and Myosin phosphatase myosin binding subunit, suggesting that M-RIP may play a role in myosin phosphatase regulation by RhoA, Authors demonstrate that Rep proteins of adeno-associated virus serotype 2 efficiently repress expression from the target site PPP1R12C promoter.,
SP_COMMENT caution:Although assigned as two separate genes (PPP1R12C and LENG3), it is probable that LENG3 does not exist by itself and is a part of the PPP1R12C gene., function:Regulates myosin phosphatase activity., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., sequence caution:Unspliced mRNA., similarity:Contains 4 ANK repeats., subcellular location:Along actomyosin filaments and stress fibers., subunit:PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12C mediates binding to myosin. Interacts via its N-terminus with PPP1CB. Interacts with IL16. Interacts with the coiled-coil domain of MPRIP., tissue specificity:Ubiquitously expressed. Highly expressed in heart.,