Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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phospholipase C gamma 1(PLCG1) phospholipase C gamma 1(PLCG1) Related Genes Homo sapiens
CYTOBAND 20q12-q13.1,
GENERIF_SUMMARY Pharmacological and molecular inhibition of phospholipase C-gamma1 inhibits growth factor receptor-mediated invasion of breast and prostate tumor cells through Matrigel in vitro., Interaction of elongation factor-1alpha and pleckstrin homology domain of phospholipase C-gamma 1 with activating its activity, Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C, Leukotriene D4 induces association of active RhoA with phospholipase C-gamma1 in intestinal epithelial cells., Phospholipase C gamma 1 is essential for NF-kappa B activation and lipid raft translocation of protein kinase C theta and the I kappa B kinase complex., activation of Src kinase by depletion of glucosylceramide-based glycosphingolipids in cultured ECV304 cells is a critical up-stream event in the activation of phospholipase C-gamma1., Stabilizes F-actin, preventing oxidative stress disruption of intestinal barrier. Essential for cellular prevention of oxidative stress of iNOS. Ability to suppress iNOS-driven reactions and cytoskeletal oxidation and disassembly., in response to Src-dependent activation of phospholipase Cgamma1, the Ras guanine nucleotide exchange factor RasGRP1 translocated to the Golgi where it activated Ras, PLC gamma-dependent component of Fc epsilon RI-mediated calcium flux leading to degranulation of mast cells is independent of PI 3-kinase, PLCgamma function and activation are mediated by GIT1 through c-Src, which integrates signal transduction by GPCRs and TKRs, tr-kit promotes the formation of a multimolecular complex composed of Fyn, PLCgamma1 and Sam68, which allows phosphorylation of PLCgamma1 by Fyn, and may modulate RNA metabolism., T-cell receptor activation of Rap1 depends on phospholipase C-gamma1, Treatment of cells of a carcinoma cell line with cysteine proteinase inhibitors results in increasing PLC1 intracellular level. Iyt is concluded that PLC1 is ubiquitinated and degraded by proteasomes., Data suggest that hyaluronan-CD44 interaction with Rac1-protein kinase N gamma plays a pivotal role in phospholipase C gamma1-regulated calcium signaling and cortactin-cytoskeleton function required for keratinocyte cell-cell adhesion and differentiation., LAB resembled a LAT molecule unable to bind phospholipase C-gamma1., Tyr-783 phosphorylation of of phospholipase C-gamma 1 is not sufficient for enzyme activation, SHP-2 has a role in regulating IL-1-induced Ca2+ flux and ERK activation via phosphorylation of PLCgamma1, SLP-76 need not interact with SH3(PLC) to activate PLC-gamma1, and the P-I region of SLP-76 serves a structural role that is sequence-independent and is not directly related to protein-protein interactions, activation of store operated channels in keratinocytes depends, at least partly, on the interaction of TRPC with PLCgamma1 and IP3R, calcium activates PLC-gamma1 via increased PIP3 formation mediated by c-src- and fyn-activated PI3K, PLCgamma1 in cell motility, functioning as a mediator of both growth factor and integrin-initiated signals, PLC-gamma1 and PLC-gamma2 both regulate the functions of ITAM-containing receptors, whereas only PLC-gamma2 regulates the function of DAP10-coupled receptors., PLCgamma1 plays a pivotal role in the migration of human colorectal cancer cells, and the upregulation of NF-kappaB binding activity and downregulation of Hsp70 expression in LoVo cells., Data show that membrane transport of p42(IP4) induced by epidermal growth factor is inhibited by stimulation of phospholipase C-coupled thrombin receptor., phospholipase C-gamma1 interaction with villin regulates epithelial cell migration, observations suggest a model in which TFII-I suppresses agonist-induced calcium entry by competing with TRPC3 for binding to phospholipase C-gamma, High phosphatidylcholine-specific phospholipase C expression on the cell membrane surface is apparently involved in the ability of natural killer (NK) cytolytic cells to lyse sensitive target cells., We show that Fas-mediated apoptosis requires endoplasmic reticulum-mediated calcium release in a mechanism dependent on phospholipase C-gamma1 (PLC-gamma1) activation and Ca2+ release from inositol 1,4,5-trisphosphate receptor (IP3R) channels., Phospholipase C-gamma1 (PLC-gamma1) activation depends on a heterotrimeric complex of adaptor proteins such as SLP76., the recruitment of PI3K to the E-cadherin/beta-catenin/p120-catenin complex via beta-catenin at the plasma membrane is required for calcium-induced phospholipase C-gamma1 activation and, ultimately, keratinocyte differentiation, Review discusses how the interaction between PLC-gamma1 and effector proteins plays a key role in on- or off-regulating PLC-gamma1-mediated cellular proliferation independent of its enzymatic activity., corecruitment of c-Cbl and PLCgamma1 to VEGFR-2 serves as a mechanism to fine-tune the angiogenic signal relay of VEGFR-2, Results demonstrate that the gamma 1 isoform of phospholipase C associates with nuclear promyelocytic leukemia protein., Cellular knockdown of protein kinase Cepsilon (PKCepsilon) leads to decreased activation of PLCgamma1 by epidermal growth factor (EGF). EGF induces tyrosine phosphorylation of PKCepsilon as well as its association with EGF receptor and PLCgamma1., Results suggest that a PLCgamma-STAT1 pathway mediates apoptotic signaling by FGFR3 in genetic dwarfism and chondrogenic cell lines., The association of PLCgamma1 with complexes containing GIT1 and beta-Pix is essential for its role in integrin-mediated cell spreading and motility. As a component of this complex, PLCgamma1 is also involved in the activation of Cdc42 and Rac1., PLCgamma-mediated activation of PKCepsilon and PKCbetaI and intracellular calcium is involved in EGF-mediated protection of tight junctions from acetaldehyde-induced insult, Controls tumor cell adhesion by controlling the RAP guanine nucleotide exchange factor (RAPGEF) molecular switch., HDAC8-selective inhibitors have a unique mechanism of action involving PLCgamma1 activation and calcium-induced apoptosis, tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases are regulated by phosphorylation, PLSCR1 is a novel amplifier of FcepsilonRI signaling that acts selectively on the Lyn-initiated LAT/phospholipase Cgamma1/calcium axis, resulting in potentiation of a selected set of mast cell responses, PLCgamma-1 and c-Src activation contribute to HNSCC invasion downstream of EGF receptor, parkin interacts with PLCgamma1, affecting PLCgamma1 steady state protein levels in human and murine models with manipulated parkin function and expression levels, while Vav-1 and LAT preferentially bound to Syk, phospholipase C-gamma1 bound to both Syk and ZAP-70, Data show a critical role of PLCgamma1 in the metastatic potential of cancer cells., Nephrin Tyr-1204 phosphorylation triggers the Ca(2+) response in a PLC-gamma1-dependent fashion., Memo was detected in complexes with cofilin, ErbB2 and PLCgamma1., VEGFR2-initiated PLCgamma1/calcium signaling is important but insufficient for full vWF release., CD244 inhibition and activation depends on CD2 and phospholipase C-gamma1, parkin is an important factor for maintaining Ca2+ homeostasis and that parkin deficiency leads to a phospholipase C-dependent increase in intracellular Ca2+ levels., YadA and invasin of Yersinia pseudotuberculosis both trigger signal transduction pathways during integrin-mediated phagocytosis into epithelial cells, which lead to the activation of Akt, PLC-gamma1, PKCalpha and -beta downstream of PI3 kinase., Results suggest that bFGF increases the [Mg(2+)](i) from the intracellular Mg(2+) stores through the tyrosine kinase/PI3K/PLCgamma-dependent signaling pathways., SH2D4A inhibited cell proliferation by suppression of the ERalpha/PLC-gamma/PKC signaling pathway., We provide evidence for a previously unrecognized phospholipase C-gamma1 (PLC-gamma1)-controlled mechanism of mTOR/p70S6-kinase activation, by regulating the localization of PLC-gamma1, RIAM plays a central role in TCR signaling and the transcription of target genes., These data elucidate the role of PLCgamma1 in FGF-2 signalling in human umbilical vein endothelial cells demonstrating its key role in FGF-2-dependent tubulogenesis., TonEBP/OREBP becomes phosphorylated at Y143, resulting in binding of PLC-gamma1 to that site, which contributes to TonEBP/OREBP transcriptional activity., PC-PLC activity increased greatly in serum of Thromboangitis obliterans patients., These data suggest that PLC-gamma1 is required for EGFR-induced SCC cell mitogenesis and the mitogenic function of PLC-gamma1 is independent of its lipase activity., miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer., These data suggest that the SH3 domain, but not the catalytic domain, is required for PLC-gamma1 to mediate EGF-induced SCC4 cell mitogenesis., These data indicate that EGF-induced cell migration is mediated by the lipase domain of PLC-gamma1 and the subsequent IP(3) generation and intracellular calcium mobilization., over expression of SH3BP2 in RAW 264.7 cells potentiates sRANKL-stimulated phosphorylation of PLCgamma1 and PLCgamma2., the CCR7/CCL21 signaling pathway leading to T lymphocyte migration on fibronectin is a beta1 integrin-dependent pathway involving transient ERK1/2 phosphorylation, which is modulated by PLCgamma1, Calcium-induced apoptosis in bladder cancer cells is delayed by HER1 receptor activation involving the Akt and PLCgamma signalling pathways., These studies suggest that Kaposi's sarcoma-associated herpesvirus has evolved to exploit ANG for its advantage via a so-far-unexplored PLC-gamma pathway for maintaining its latency., propose c-Cbl as an angiogenic suppressor protein where upon activation it uniquely modulates PLCgamma1 activation by ubiquitination and subsequently inhibits VEGF-driven angiogenesis, In cultured vascular smooth muscle cells, phospholipase Cgamma1 expression was required for platelet-derived growth factor-induced ERK1/2 nuclear translocation, Elk-1 phosphorylation, and subsequent repression of SM alpha-actin gene expression., The Epo/EpoR complex plays a critical role in the adhesion and migration of rat fibroblasts, and its functional inactivation is associated with PLC-gammal-dependent reduction of cell-matrix adhesion and this also affects cell migration., PLC-gamma1, but not phospholipase C-beta3,is required for the migration of T cells in response to stromal cell-derived factor-1, Translocation of PLC-gamma 1 to the cell membrane and the associated calcium signal were enhanced only in mast cells responding to EP3 prostaglandin E2 receptor agonist sulprostone., PLCgamma plays a key role in RhoGDI2-mediated cisplatin resistance and cell invasion in gastric cancer cells., our approach, which is applicable to any set of interval scale traits that is heritable and exhibits evidence of phenotypic clustering, identified three new loci in or near APOC1, BRAP, and PLCG1, which were associated with multiple phenotype domains., Report the interplay of HER2/HER3/PI3K and EGFR/HER2/PLC-gamma1 signalling in breast cancer cell migration and dissemination., PDK1 and PLCgamma1 act on the same signalling cascade, and the PDK1/PLCgamma1 pathway is required for regulation of cell invasion., The oncogenic truncation of this region elicits conformational changes that interfere with the Vav1-mediated activation of PLCgamma1 and that inhibit calcium mobilization., Data indicate that Akt expression was up-regulated with high glucose and insulin in both cell lines, whereas PLCgamma expression was enhanced in colon cancer cells only., analysis of two distinct mechanisms by which phospholipase C-gamma1 mediates epidermal growth factor-induced keratinocyte migration and proliferation, T cell receptor (TCR)-mediated proliferation is impaired in PLCgamma1/PLCgamma2 double-deficient T cells compared with PLCgamma1 single-deficient T cells., High expression of PLCgamma1, and of its activated forms, is associated with a worse clinical outcome., The role of four domains of human PLCG1 defined by structural and biochemical investigation., PLC-gamma1 is highly expressed in brain and participates in neuronal cell functions mediated by neurotrophins. (Review), The degradation of zonula occludens-1 (ZO-1), and claudin-2 exhibited a great dependence on the activation of the transient receptor potential melastatin (TRPM) 2 channel, phospholipase Cgamma1 (PLCgamma1) and the protein kinase Calpha (PKCalpha) signaling cascade., study showed that PLC-gamma directly binds c-Src through its SH2 domains, and this interaction is necessary for carbachol mediated inhibition of NHE3 activity in Caco-2/BBe/NHE3 cells, Phospholipase C gamma1 plays a key role in cell migration and invasion. [review], A portion of PLC-gamma1 phosphorylated on tyrosine 783 is not found at LAT-containing clusters but instead is located at TCR-containing clusters., Metastatic outcome can be dictated by the constitutive competition between Grb2 and Plcgamma1 for the phosphorylation-independent binding site on FGFR2., Increased proliferative and survival mechanisms in cutaneous T-cell lymphoma may partially depend on the acquisition of somatic mutations in PLCG1 and other genes that are essential for normal T-cell differentiation., PLCgamma1 signaling is the dominant pathway in promoting limbic epileptogenesis., PLCG1, a signal transducer of tyrosine kinases, encoded a recurrent, likely activating p.Arg707Gln missense variant in 3 of 34 cases of angiosarcoma., Results reveal that PLCG1 is genetically altered in a significant portion of Cutaneous T-cell lymphomas., Extracellular K(+) concentration regulated the levels of activated PLC-gamma1, chromosome X, and carbachol-stimulated intracellular Ca(2+) mobilization in human endothelial cells, Results provide evidence that PTPRB and PLCG1 mutations are driving events in a subset of secondary angiosarcomas., The activation of the gamma1 isoform of phospholipase C (PLCgamma1) is critical for pressure sensing in cerebral arteries and subsequent vasoconstriction., This SOCS7 knockdown-attributed effect could be due to a precise anti-PLCg-1 role., these findings indicate that the PLCgamma1-R707Q mutation causes constitutive activation of PLCgamma1 and may represent an alternative way of activation of KDR/PLCg1 signaling besides KDR activation in angiosarcomas, Recurrent presence of the PLCG1 S345F mutation is associated with nodal peripheral T-cell lymphomas., Data from structural, genetic, and mechanistic studies on the role of PLCG1 in cell biology suggest that dysfunctional forms of PLCG1 are linked to immune disorders and cancer. [REVIEW], PLCgamma1 is part of the molecular mechanism., PLLG1 protein mutations are uncommon in cutaneous T-cell lymphomas., hsa-miR-665 and hsa-miR-95 were downregulated in GSRCC but upregulated in intestinal gastric adenocarcinoma, and the relatively differential expression of the miRNAs negatively controlling their target genes, GLI2 and PLCG1, expression of PLC-gamma1 and PIKE positively correlated with the tumor differentiation of oral squamous cell carcinoma., In a transgenic mouse model, PLCgamma1 is the dominant signaling effector by which activation of TrkB promotes epilepsy., Report PLCG1 genetic alterations in angiosarcomas.,
SP_COMMENT catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol., cofactor:Calcium., domain:The SH3 domain mediates interaction with CLNK (By similarity). The SH3 domain also mediates interaction with RALGPS1., function:PLC-gamma is a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase., PTM:The receptor-mediated activation of PLC-gamma-1 and PLC-gamma-2 involves their phosphorylation by tyrosine kinases in response to ligation of a variety of growth factor receptors and immune system receptors., PTM:Ubiquitinated by CBLB in activated T-cells., similarity:Contains 1 C2 domain., similarity:Contains 1 EF-hand domain., similarity:Contains 1 PH domain., similarity:Contains 1 PI-PLC X-box domain., similarity:Contains 1 PI-PLC Y-box domain., similarity:Contains 1 SH3 domain., similarity:Contains 2 PH domains., similarity:Contains 2 SH2 domains., similarity:Contains 3 PH domains., subunit:Interacts with AGAP2 via its SH3 domain (By similarity). Interacts with phosphorylated LAT upon TCR activation. Interacts with the Pro-rich domain of TNK1 via its SH3 domain. Associates with BLNK, VAV1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB in activated T-cells; which inhibits phosphorylation. Interacts with SHB. Interacts via its SH3 domain with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively regulated by arginine methylation of KHDRBS1/SAM68. Interacts with INPP5D/SHIP1 and CLNK (By similarity). Interacts with RALGPS1. Interacts (via SH3 domain) with HEV ORF3 protein.,