Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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plasminogen activator, urokinase receptor(PLAUR) plasminogen activator, urokinase receptor(PLAUR) Related Genes Homo sapiens
CHROMOSOME 19,
CYTOBAND 19q13,
ENSEMBL_GENE_ID ENSG00000011422,
GENERIF_SUMMARY uPA regulates uPAR expression at a post-transcriptional level, by promoting the binding of uPAR mRNA to a stabilizing factor., uPA-dependent VSMC adhesion is a function of selective Vn phosphorylation by the ectoprotein kinase CK2, oxidative stress in AD and microglial activation establish a possible involvement of uPAR in AD pathogenesis., Investigation of the role of Endo180/urokinase-type plasminogen activator receptor-associated protein as a collagenase 3 (matrix metalloproteinase 13) receptor, Amino acid substitutions at serine residues in UPA prevent signaling through UPAR, and prevents physical association of UPAR with alphavbeta5 vitronectin receptor, which is required for MCF-7 urokinase-dependent cell migration., UPA receptor is weakly upregulated by bFGF in normal muscle satellite cells, while it is strongly up-regulated by TGFbeta, mainly in dystrophic myoblasts., Coculture of monocytes and vascular smooth muscle results in increased expression of cell surface-associated uPAR in VSMC and up-regulation of UPA in monocytes, resulting in VSMC migration., REVIEW, Targeting urokinase-type plasminogen activator receptor on human glioblastoma tumors with diphtheria toxin fusion protein DTAT., uPA receptor is expressed in benign and malignant thyroid tumors., essential role in acute inflammation as well as in chronic degenerative vascular processes such as atherosclerosis, Structural analysis of the interaction between urokinase-type plasminogen activator and its receptor, Interferon-alpha (Intron A) upregulates urokinase-type plasminogen activator receptor gene expression, interaction with urokinase mediates inhibitory signal for HIV-1 replication, expression of uPA and uPAR is associated with the clinical behaviour of bladder neoplasms, Human breast adenocarcinoma cell lines promote angiogenesis by providing cells with uPA-PAI-1 and by enhancing their expression., prognostic biomarker for endometrial cancer, MCP-1, MCP-2 & MCP-3 increased uPAR mRNA levels in time-dependent & dose-dependent manners. Up-regulation of uPAR in target cells might be an important and common feature of chemoattractants., circulating UPA is not up-regulated by the circulating P105 fraction of the HER-2/neu proto-oncogene, Bikunin downregulates constitutive & PMA-stimulated uPAR mRNA & protein Through suppression of upstream ERK cascade targets, whether cells were treated with exogenous bikunin or transfected with bikunin gene., Mutation of NFKB1 protein's promoter binding site (-45 bp) impaired the ability of ITGB3BP to downregulate this protein., uPA-mediated uPAR cleavage and D1 removal, occurring on the cell surface of several cell types, can play a fundamental role in the regulation of multiple uPAR functions, seprase and the urokinase plasminogen activator receptor (uPAR), co-localize in the plasma membrane of LOX malignant melanoma cells, recognition of uPA by alpha(M)beta(2) allows for formation of a multicontact trimolecular complex, in which a single uPA ligand may bind to both uPAR and alpha(M)beta(2); interaction of uPA with each receptor influences cell adhesion and migration, Urokinase receptor surface expression regulates monocyte adhesion in acute myocardial infarction, correlates with cox2 expression levels and is responsible for poor prognosis of colorectal cancer, The diphtheria toxin/urokinase fusion protein (DTAT) is selectively toxic to CD87 expressing leukemic cells, showing that specific CD87 binding is one factor important in the sensitivity of patient's leukemic blasts to DTAT, uPAR up-regulated the Mac-1 adhesion to fibrinogen, and focal adhesion kinase and MAPK were involved in this regulation, the interaction between uPAR and Man-6-P/IGF2R is a low percentage binding event and that suPAR and full-length uPAR bind the Man-6-P/IGF2R by different mechanisms., uPAR expression in lung cancer is regulated at a posttranscriptional level by uPA, The expression of uPAR was significantly correlated with gastric tumor size, depth, lymph node involvement, differentiation & vascular invasion., Plasma uPAR levels are greater in those with bladder cancer than in healthy subjects (P <0.001) and greatest in patients with metastases to distant lymph nodes (P = 0.042)., urokinase receptor D2 contains two distinct ligand binding sites for urokinase-type plasminogen activator and vitronectin, data indicating that the structure of the kringle as well as its interaction with the growth factor domain govern urokinase binding to the urokinase receptor, Results suggest that uPAR can engage distinct signaling pathways involving different partner proteins that are functionally and physically segregated from one another in both lipid raft and non-raft domains of the plasma membrane., Results suggest that Endo180 is a crucial link between urokinase-type plasminogen activator and its receptor and setting of the internal cellular compass., predictors of human immunodeficiency virus (HIV) disease progression (review), signaling for the uPAR response, as mediated by B. burgdorferi, proceeds with CD14 and TLR2 as partial contributors, Significant increases in uPAR were found in pretreatment determinations of patients with advanced small-cell lung cancer or non-small-cell lung cancer., urokinase and urokinase receptor mRNAs are stabilized by HuR linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2, Reduced expression of urokinase plasminogen activator receptor is associated poorly differentiated ovarian tumors and metastases, uPA and uPAR are up-regulated during acute renal allograft rejection, role of urokinase plasminogen activator receptor (uPAR) and c-erbB-2 in breast and ovarian cancer, uPAR plays an active role in breast cancer metastasis and may therefore be a promising target for new biologic therapies., uPAR and integrin receptors synergistically regulate the levels of fibronectin in the extracellular matrix, up-regulation of uPAR expression by Bcl-2 in hypoxia is modulated by Sp1 DNA binding activity through the ERK signaling pathway, MMP-9 and su PAR levels might be used as a marker for disease activity and may contribute to blast cell dissemination. MMP-9 and suPAR may be target molecules in the strategy of treatment of AML., IL-1-induced expression of UPAR and its co-localization with MMPs were studied in articular chondrocytes., Irradiation induced tumor hypoxia, and tumor hypoxia induced up-regulation of uPAR in human melanoma xenografts in nude mice., These results demonstrate that phosphoglycerate kinase regulates uPAR expression at the post-transcriptional level., enhanced levels of suPAR fragments in the urine of cancer patients is likely to originate from uPAR expressed in the tumour tissue, Western blotting of endothelial cell surface of a number of sites showed higher amounts of tissue plasminogen activator annexin II on cerebral endothelial cell. In contrast, expression of u-PA receptor was the same for all ECs, KLF4 is a novel regulator of u-PAR expression that drives the synthesis of u-PAR in the luminal surface epithelial cells of the colon, Results suggest that hypoxia increases tumor cell invasion by up-regulating urokinase plasmalogen activator receptor expression, possibly through ERK and p38 kinase signaling pathways., Data indicate that uPAR is potentially an important prognostic factor in bladder carcinoma., demonstrated focused activation of proteolytic enzymatic activity in several cell types and showed that the uPA/uPAR system is an important contributor to focal pericellular proteolysis, uPAR forms a signaling complex containing integrin alpha(v)beta3 or alpha5beta1, caveolin, & Src kinase Yes in endothelial cells. uPAR is a target of HKa activity at the endothelial cell surface., Overexpression of uPAR in the central nervous system of patients with AIDS dementia suggests that the uPA/uPAR system may contribute to the tissue injury and neuronal damage in this disease., TF/FVIIa complex up-regulates the transcription of u-PAR in human ovarian cancer cells., the promoter region of uPAR from -136 to +9 may interact with relevant nuclear factors, resulting in various levels of uPAR expression, Data describe the cyclic variation and distribution of urokinase plasminogen activator (uPA), uPA receptor and plasminogen activator inhibitor 1 (PAI-1) mRNA in normal endometrium., Any alterations in the domain structure of uPAR reduce its expression.Only the intact receptor with all 3 domains can sustain the direct cell adhesion on vitronectin-rich matrices found at sites of inflammation and injury., Amounr is significantly increased during storage of blood transfusion components, an accumulation that is reduced using pre-storage leucofiltration., Antisense to uPAR significantly restricted invasion of the highly invasive DU145 WT cells through Matrigel and reduced aggressiveness of tumors in nude mice., uPA/uPAR ligation anchors the complex to the actin cytoskeleton and is a part of the mechanism responsible for uPA-induced cell migration in fibroblasts., cleavage of juxtamembrane domain by plasmin, Increased expression of plasminogen activator, urokinase receptors is associated with transitional cell carcinoma of the human bladder, gene expression of the uPAR and underlying mechanisms were analyzed during the development of atherosclerosis in the aorta of apolipoprotein E-deficient mice, G-CSF-induced upregulation of uPAR on circulating CD33+ and CD14+ cells, increased uPAR shedding & serum c-suPAR, which could contribute to the mobilization of HSCs by promoting their FPR-mediated migration and by inducing CXCR4 desensitization., Human basophils express the urokinase receptor on their surface in both the intact (domains D1D2D3) and the cleaved (D2D3) form., uPAR immunoreactivity correlated with the mRNA expression and was, in addition, found in neutrophils in prostttic cancer., These findings suggest that AdCC has a proclivity for migrating to types I and IV collagens due to the overexpression of uPAR, which plays a key role in focal adhesion assembly and migration., importance of uPAR to define higher risk subgroups of breast cancer patients with micrometastatic disease, uPAR plays a key role in promoting macrophage infiltration into the arterial wall of ApoE(-/-) mice, urokinase receptor proteolytic function is regulated by the tetraspanin CD82, Direct binding of uPAR with alpha5beta1 implies a modified "bent" integrin conformation can function in an alternative activation state with this and possibly other cis-acting membrane ligands., review of signal transduction and events linking the uPA/uPAR system to cell growth and apoptosis, expression and assembly of uPAR co-receptors in a specific cell type determines the response to uPA, uPAR and MMP-9 have roles in inhibiting cell proliferation and can reduce the levels of phosphorylated forms of MAPK, ERK, and AKT signaling pathway, basic capacity of separated epithelial and stromal cells from all three types of tissue to release uPA, PAI-1, and suPAR without any paracrine influence, as in vivo, review of mechanisms by which uPAR participates not only in the modulation of cell-cell and cell-extracellular matrix interactions, but also in the control of extracellular signals determining the proliferative state of a cell, UPA-R positivity may identify subtypes of acute myeloid leukemia and thus a more intensive induction therapy regimen could be considered., Plasma levels of different forms are incsreased and associated with immune activation in HIV patients, and are an independent predictors of mortality in these patients., Domain 2 of the urokinase receptor plays a pivotal role in the regulation of uPAR-integrin alphavbeta3 interactions, urokinase receptor-derived SRSRY peptide regulates cross-talk between fMLP and vitronectin receptors, The level of urokinase-type plasminogen activator receptor (uPAR) does not correlate with cerebrospinal fluid to serum albumin ratio, suggesting an unimportant role for uPAR in HIV-induced blood-brain-barrier disruption., Expression in noninvasive tumors suggests that uPAR may have other biologic functions in addition to promotion of tumor invasion., specific streptococcal surface protein-pharyngeal cell receptor interaction mediated by Streptococcal surface dehydrogenase and uPAR is modulated during group A Streptococcus infection, uPAR mRNA binding activity as well as PGK-mediated regulation of uPAR mRNA are independent of PGK enzymatic activity, A novel mechanism of uPAR gene regulation in lung epithelial cells was shown in which cis elements within a 110 nt uPAR mRNA 3'UTR sequence interact with hnRNPC to regulate uPAR mRNA stability., Urokinase plasminogen activator receptor is overexpressed in renal cell carcinoma and could function as tumour marker., a complex signaling network operating downstream of uPA-uPAR actively advances tumor cell invasion, proliferation, and survival of prostate cancer cells, The uPAR-associated protein up-regulation is involved in the process of extracellular matrix proteins degradation and HUVEC cell-migration., Both wild-type (wt) and human cleavage resistant-uPAR are able to mediate uPA-induced migration, are constitutively associated with the EGFR, and associate with alpha3beta1 integrin upon uPA binding, Our results suggest that PAI-1 is a novel potential marker of initial invasion in oral SCC, and that the coordinated expression of PAI-1 with uPAR and lam-gamma2 sustain the features of the early invasive cancer cells., crystal structure at 1.9 angstroms of the urokinase receptor complexed with the urokinase amino-terminal fragment and an antibody against the receptor, These results demonstrated that uPAR is induced by hypoxia and that increased uPAR expression is mediated by ERK phosphorylation, which in turn is modulated by iNOS/NO in MDA-MB-231 cells., Here we demonstrate uPAR is a target for tissue kallikrein 4[hK4], cleaved in the D1-D2 linker and D3 domain. hK4 may modulate tumor-associated uPA/uPAR activity by activating the pro-enzyme form of uPA or cleaving the cell surface-associated uPA receptor, IL-1alpha can induce selective upregulation of alpha6beta1-integrin and uPA/uPAR in pancreatic cancer cells and these changes may modulate the aggressive functions of pancreatic cancer., This study supports matrix-induced clustering of alpha3beta1 integrin promotes uPAR/alpha3beta1 interaction; potentiating cellular signal transduction pathways culminating in activation of uPA expression and enhanced uPA-dependent invasive behavior., In situ hybridization revealed a strong expression signal for SGRG in spermatogonia, but not in spermatocytes., Results clearly suggest the involvement of the uPA-uPAR system in cell survival and proliferation in addition to their role in tumor progression., These results suggest that low glucose levels in malignant cancers increase tumour cell invasiveness by stimulating urokinase plasminogen activator and plasmin activity., endothelial progenitor cells are characterized by high intrinsic uPA/uPAR-dependent proteolytic potential that could contribute to their invasive and angiogenic behaviour, ligand engagement of uPAR promotes cell survival by activating Bcl-xL transcription through the MEK/ERK- and phosphatidylinositol 3-kinase/Akt-dependent pathways, Intratumoral injections of the plasmid vector expressing siRNA for uPAR resulted in regression of pre-established, subcutaneous meningioma tumors., Novel pathway for uPAR regulation involving reactive oxygens such as superoxide anion., urokinase-type plasminogen activator (uPA) and its soluble receptor may not have roles in progression of atopic eczema/dermatitis syndrome, as plasma levels of uPA and suPAR are similar in patients at different stages of AEDS and healthy subjects, aspirin upregulates steady-state level expression of uPAR mRNA as well as expression of uPAR protein., Data suggest that the function of alphaMbeta2 integrin domain and integrin-like domain is disrupted, possibly by stearic shielding, by uPAR when both uPAR and alphaMbeta2 integrin molecules interact., uPAR cell surface density may be a contributory factor in colon cancer progression., study shows uPA & uPAR are overexpressed in primary prostate cancer cells & surrounding stromal cells (Gleason score >/=7) & more than 90% lymph node metastases but not in normal prostate, benign prostate hyperplasia or prostatic intraepithelial neoplasia, A novel intragenic enhancer in the u-PAR gene required for constitutive and inducible expression was defined., uPAR expression of lung airway epithelial cells is regulated at the level of mRNA stability by inhibition of protein tyrosine phosphatase-mediated dephosphorylation of uPAR mRNA binding proteins and demonstrate that the process involves SHP2., Expression of HER-2 and uPAR in primary tumors predicted gene status in 100 and 92% of patients, respectively, Pro188, Asn190, Gly191, and Arg192 residues of uPAR are the key residues for the antibody recognition, while Pro189 and Arg192 render specificity of ATN615 for human uPAR, Urokinase receptor (uPAR) is required for maximal alpha5beta1 integrin-dependent responses to fibronectin that promote tumor cell invasion., Proteolytic regulation of uPAR by airway trypsin-like kinase is likely to modulate cell adherence and motility, as well as tissue remodeling during the inflammatory response in the airways., Elevation of plasma uPA and uPAR levels in CaP patients are partly caused by local release from the prostate. Plasma levels of uPA and uPAR are associated with biologically aggressive CaP, disease progression after radical prostatectomy, and metastasis, These data suggest Pdcd4 as a new negative regulator of intravasation, and qas the invasion-related gene u-PAR. It is the first study to implicate Pdcd4 regulation of gene expression via Sp1/Sp3., uPAR of cancerous cells was more often observed in lobular carcinomas., uPA and uPAR are involved in generation of drug-resistant small-cell lung cancer cell phenotype. uPAR-positive cells may define a functionally important population of cancer cells in SCLC., uPAR behaves as a lynchpin in promoting tumorigenesis by forming functionally active multiprotein complexes., PLAUR and the somatomedin B region of VTN direct the localization of UPA to focal adhesions in microvessel endothelial cells., ERK cascade regulates motility of hepatocellular carcinoma cells via uPAR production and p70S6K phosphorylation., forced expression of urokinase receptor coupled with exogenous addition of urokinase restored migration of CTR-knock-down spheroids., These data support a novel hypothesis that maintaining full-length uPAR on the cell surface regulates the fibroblast to myofibroblast transition and that down-regulation of uPAR is necessary for myofibroblast differentiation., These data suggest that Src-induced u-PAR gene expression and invasion/intravasation in vivo is also mediated via AP-1 region -190/-171, especially bound with c-Jun phosphorylated at Ser(73/63)., LasB is able to cleave uPAR both within the sequence linking D1 to D2 and at the carboxy terminus of D3., Altered expression of UPAR was observed in high-risk soft tissue sarcomas., These observations demonstrate a novel regulatory role for p53 as a uPAR mRNA binding protein that down-regulates uPAR expression, destabilizes uPAR mRNA, and thereby contributes to the viability of human airway epithelial or lung carcinoma cells., A direct uPAR-vitronectin interaction is both required and sufficient to initiate downstream changes in cell morphology, migration, and signal transduction., Simultaneous down-regulation of uPAR and uPA induced caspase-8 mediated apoptosis., Results suggest that in hypoxia, uPAR activates diverse cell signaling pathways that cooperatively induce epithelial-mesenchymal transition and may promote cancer metastasis., High tumour cell C4.4A expression is associated with shorter survival for non-small cell lung cancer patients., review of uPA - uPAR interactions with membrane proteins to modify signal transduction pathways and their role in oral squamous cell carcinoma, uPAR-del4/5 and rab31 mRNA represent independent prognostic markers in breast cancer and may be components of different, but possibly associated, tumor-relevant signaling pathways., The role of the ligand uPA on uPAR localization and on the composition of the lipid membrane microdomains, is studied., Plasma suPAR levels, as measured by the suPARnostic(R) assay, were strongly predictive of survival in ART-naive HIV-1 infected patients. Furthermore, plasma suPAR levels were not influenced by uPAR promoter polymorphisms., elevated in polycystic ovary syndrome, The carotid atherosclerosis is independently related to uPA/its soluble receptor system in dialysis patients, The data demonstrate that cell surface protein assemblies are important in regulating the dynamics and localization of uPAR at the cell membrane and the exchange of monomers and dimers., uPAR is required to activate alphavbeta3 integrin in podocytes, promoting cell motility and activation of the small GTPases Cdc42 and Rac1, The expression of constitutively activated RelA/NF-kappaB is associated with malignancy potential in astrocytic tumors and may play a critical role in the regulation of u-PA expression and invasiveness in gliomas., suPAR, a soluble form of urokinase plasminogen activator receptor, inhibits human prostate cancer cell growth and invasion., the urokinase-type plasminogen activator receptor is upregulated by lysophosphatidic acid in human gastric cancer cells, The plasma uPAR and uPA levels in nosebleed patients before treatment is higher than that in normal group., The change of plasma suPAR level in multiple myeloma contributes to predict the development and prognosis of the disease., suPAR associated to important glucose metabolic aberrations in HIV-infected patients on HAART; suPAR was stable after a glucose challenge, A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor., reports the crystal structures of uPAR in complex with both urokinase (uPA) and vitronectin and reveal that uPA occupies the central cavity of the receptor, whereas vitronectin binds at the outer side of the receptor, UPAR mediates anticancer activity of PEDF., The structural biology of uPAR is reviewed with special emphasis on its multidomain composition and the interaction with its natural protein ligands, Role of the serine protease urokinase-type plasminogen activator and its high affinity receptor uPAR/CD87 in chronic kidney disease [REVIEW]., distribution of genotypes and frequencies of alleles of the (CA)(n) repeat polymorphism in intron 3 of the uPAR gene, uPAR antigen levels and microvessel density in tumour and distant mucosa samples from 52 patients with colorectal cancer, Report increased expression of uPAR by Helicobacter pylori in gastric epithelial cells., analysis of conformational changes in the alpha(M)beta(2) headpiece and reorientation of its transmembrane domains when alpha(M)beta(2) interacts with uPAR, urokinase-type plasminogen activator receptor has a role in oral squamous cell carcinoma, the plasma levels of uPA and uPAR are closely related to the degree and period of inflammation in patients with acute or chronic hepatitis B, and that uPA and uPAR might be important indicators for disease progression, Interaction of SRPX2 with uPAR involved in the functioning, the development and disorders of the speech cortex., uPAR cooperates with integrin complexes containing beta(3) integrin to drive formation of the p130Cas-CrkII signaling complex and activation of Rac, resulting in a Rac-driven elongated-mesenchymal morphology, cell motility, and invasion., Free fatty acids modify the expression for uPAR in the PMA-differentiated human monocyte/macrophage-like cell line U937., uPA and uPAR in the synovial fluid may play a role in the pathogenesis of temporomandibular disorders., Differential proteome expression is associated with UPAR suppression in malignant epithelial cancer., the simultaneous downregulation of uPAR and MMP-9 induces apoptosome-mediated apoptosis through FADD-associated protein RIP and caspase 9, The aim of this study was to investigate whether UPAR co-localises with macrophages in symptomatic carotid plaques, and whether UPAR expression is associated with plaque rupture., Enhanced expression of urokinase-type plasminogen activator receptor is associated with the invasion of glioblastoma., Data suggest that production of the active form of suPAR by neutrophils may contribute to the recruitment of monocytes and other cells to the sites of acute inflammation where neutrophil accumulation and activation occur., uPAR and beta1-integrin interactions are essential to signals induced by integrin matrix ligands or uPA in lung cancer cells., either uPA/uPAR interaction, Mac-1 activation, or prevention of its association with uPAR triggers a signaling pathway leading to the inefficient release of HIV from monocytic cells, uPA/uPAR downregulation inhibits radiation-induced migration, invasion and angiogenesis in IOMM-Lee meningioma cells and decreases tumor growth in vivo., Expression of kallikrein 7 diminishes pancreatic cancer cell adhesion to vitronectin and enhances urokinase-type plasminogen activator receptor shedding., suPAR, prevents the interaction of urokinase with membrane-anchored uPAR on residual normal cells., Caveolin-1 plays a dual role in the fibronectin assembly regulated by uPAR signaling., These results indicate that, in addition to the ligand-induced endocytosis of uPAR, efficient surface expression and membrane trafficking might also be driven by an uncommon macropinocytic mechanism coupled with rapid recycling to the cell surface., NYD-SP8 has a role in regulating ECM degradation, providing a novel mechanism that modulates urokinase signalling in the suppression of cancer progression, EGF induces uPAR expression via ERK-1/2, AP-1, and NF-kappaB signaling pathways and, in turn, stimulates cell invasiveness in human gastric cancer AGS cells, M6P/IGF2R controls cell invasion by regulating alphaV integrin expression and by accelerating uPAR cleavage, leading to the loss of the urokinase/vitronectin/integrin-binding site on uPAR., study evaluated the expression level of uPAR mRNA and the presence of isolated tumour cells in bone marrow and peripheral blood in gastric cancer patients and clarified its clinical significance, Data show the effects of nitric oxide and hydrogen peroxide on the expression of tissue-type plasminogen activator (t-PA), urokinase-PA, u-PA receptor, and plasminogen activator inhibitor type 1 (PAI-1) in human umbilical vein endothelial cells., The higher expression of uPAR/uPA in most of the opportunistic cerebral lesions supports their role in these diseases, suggesting their contribution to tissue injury., analysis of urokinase, urokinase receptor and plasminogen activator inhibitor-1 in colon cancer liver metastases, The positive expression of uPA and uPAR in hypopharyngeal carcinoma were significantly higher than in normal tissue., Urokinase & its receptor UPAR exert a regulatory effect on physiologic cell migration as well as tumor growth and metastasis. Review., uPAR is under transcriptional control of HIF and that this is important for hypoxia-induced metastasis, survivin is an essential mediator of arthritogenic properties of uPA regulating its synthesis in synovial fibroblasts and uPAR expression in leucocytes, role of uPAR in the phagocytosis of apoptotic cells, the 20-26 amino acid residues of uPA are important for the binding between uPA and uPAR, and that the electrostatic interactions between the charged amino acid residues existing in both uPA and uPAR have large contribution to the binding, the expression levels of u-PAR in peripheral blood and bone marrow evaluated preoperatively indicate the potential of breast cancer to relapse or metastasize after surgery., u-PAR may interact with multiple integrins in normal human lung fibroblasts thereby promoting attachment, spreading, and migration., siRNA to uPAR significantly inhibited cell proliferation and migration and stimulated apoptosis, to a greater extent than uPA siRNA., uPAR gene amplifications identify a subgroup of particularly aggressive tumors, LPS promotes tumour cell ECM adhesion and invasion through activation of the u-PA system in a TLR-4- and NF-kappaB-dependent manner., This study represents the first report to identify PLAUR as a potential asthma susceptibility gene and determine PLAUR regions underlying this association, including a role in influencing plasma PLAUR levels, study demonstrated that uPA and PAI-1 are useful predictors of distant metastases in a subset of early stage, node-negative breast cancer patients, study shows that uPAR is upregulated upon exposure to B. burgdorferi; uPAR plays an important role in phagocytosis of B. burgdorferi by leukocytes, Plasminogen activator inhibitors regulate cell adhesion through a uPAR-dependent mechanism., Tumor stroma is the predominant UPAR-expressing tissue in human breast cancer, High u-PAR-gene expression is associated with thyroid neoplasms., uPAR may promote cancer metastasis independent of uPA., These results demonstrate that uPAR-initiated cell signaling may be targeted to reverse EMT in cancer., Data show that uPAR expressed in macrophages and neutrophils in all cases., Soluble urokinase receptor conjugated to carrier red blood cells binds latent pro-urokinase and alters its functional profile., Link overexpression of uPAR to the pathogenesis of malignant pleural mesothelioma, and demonstrate that this receptor contributes to accelerated tumor growth in part through interactions with uPA., Protein analysis confirmed expression of multiple different forms of urokinase plasminogen activator receptor (UPAR) in the same cells as well as expression of soluble uPAR in cell supernatants, Abnormally high levels of Annexin II and u-PAR expression in acute promyelocytic leukemia cells may contribute to the increased production of plasmin, leading to primary hyperfibrinolysis., uPAR-mediated VSMC differentiation employs lipid rafts., 3,3'-Diindolylmethane (B-DIM) down-regulates uPA-uPAR in aggressive breast cancers but in the absence of uPA-uPAR, B-DIM can directly inhibit VEGF and MMP-9 leading to the inhibition of cell growth and migration of breast cancer cells, ECRG2 is involved in the regulation of cell migration/invasion through uPA/uPAR/beta1 integrin pathway., uPA, but not uPAR, is an independent prognostic factor and that this negative effect on survival is relevant specifically for mismatch repair-proficient colorectal cancers., Neutrophils contribute to or are responsible for the generation of increased suPAR levels during the inflammatory response and, release the chemotactically active form of suPAR that might be involved in lymphocyte recruitment into the inflamed tissues., lithocholic acid induces uPAR expression via Erk-1/2 and AP-1 pathway and, in turn, stimulate invasiveness of human colon cancer cells., CRG2 regulates invasion/migration partly through ECM degradation and uPA/uPAR/FPRL1 pathway, This study provides tentative evidence that the asthma associated gene PLAUR also influences baseline lung function in smokers, analyzed the role of Spred2 in the urokinase-type plasminogen activator (uPA) stimulation, EMT and cell migration by TGF-beta1, expession is associated with hair follicule morphogenesis and cell migration, As expression of members of the uPA system in tumour tissue and serum is additively correlated with prognosis of soft tissue sarcoma patients., Simultaneous downregulation of HER2 and uPAR may offer an effective tool for breast cancer therapy., During melioidosis, uPAR contributes to the recruitment of neutrophils to the primary site of infection and the capacity of neutrophils to phagocytose Burkholderia pseudomallei., Increased uPAR expression promotes alpha(3)beta(1) integrin association, resulting in increased mitogen-activated protein kinase signaling and transcriptional activation, leading to the formation of more aggressive tongue tumors., A combination approach using uPA and uPAR siRNA therapy along with radiation treatment produced target-specific effects with regard to inducing apoptosis in meningioma., the interaction between urokinase receptor and heat shock protein MRJ enhances cell adhesion, Demonstrate increased expression of uPA and uPAR in human seminomas with respect to normal testis tissues, which may be relevant in testicular cancer progression., Increased uPAR expression induced by anti-Ro60 binding to the apoptotic fetal cardiocyte provide a molecular basis by which these antibodies inhibit efferocytosis and lead to scar of the fetal conduction system., uPAR acts as a cofactor for iC3b binding to CR3 and regulates CR3-mediated phagocytosis., Levels of uPAR, PAI-1 and CAP18 were elevated in induced sputum of COPD I + II and COPD III + IV patients, compared with those of healthy non-smokers and healthy smokers., demonstrate that the uPAR-del4/5 mRNA splice variant mediates tumor-relevant biological processes in vitro and in vivo, Increased expression of uPAR in surgical specimens of human frontal cortex may be associated with intractable epilepsy., Findings provide molecular mechanism for the G0/G1 arrest induced by the downregulation of cathepsin B and uPAR in SNB19 and U251 glioma cells., A noninvasive in vivo fluorescence-mediated tomography technique is used to image leukocyte recruitment in an inflammatory mouse model that quantifies a novel macrophage recruitment defect in u-PAR-deficient mice., hSpry1 and HAX1 proteins are putative candidate proteins that interact with uPAR., uPA/uPAR downregulation suppresses angiogenesis in endothelial cells induced by glioblastoma cell lines, In invasive breast cancer uPAR expression in invasive carcinoma cells, but not in stromal cells, has a significant impact on patients' prognosis, and contributes to a more aggressive tumour phenotype., The FOXP2-SRPX2/uPAR network provides exciting insights into molecular pathways underlying speech-related disorders., Results suggest that uPAR plays a pivotal role in the development of adipose tissue through PI3K/Akt pathway., role of single nucleotide polymorphism of uPA and uPAR in non-small cell lung cancer, The UPAR rs344781 gene variant is associated with the systemic sclerosis vascular phenotype., Results show that uPAR expression regulates the adhesive and migratory ability of CXCR4-expressing cells through a mechanism involving fMLP receptors and alpha-v integrins., RNAi-mediated downregulation of uPAR and cathepsin B initiates caspase-dependent mitochondrial apoptosis in U251 cells and caspase-independent mitochondrial apoptosis in 5310 cells, results suggest that MSP induces uPAR expression via MAPK, AP-1 and NF-kappaB signaling pathways, uPAR might guide/control the trafficking of mesenchymal stem cells to the injured vascular wall and their differentiation towards functional smooth muscle cells., cholesterol levels in lipid rafts are critical for the migration, invasion, and angiogenesis of breast carcinoma cells and could be a critical regulatory factor in these cancer cell processes mediated by uPAR and MMP-9., The study demonstrated that in papillary thyroid cancer the increased gene expression of uPA and uPAR is associated with tumor invasiveness, Data show that siRNA in combination with IR effectively reduced both MMP-9 and uPAR expression, thereby leading to increased radiosensitivity of medulloblastoma cells., Anti-tumor efficacy of down-regulation of uPA or uPAR in medulloblastoma tumors to target hypoxia-induced cell EMT, invasion and migration, to achieve better therapeutic outcomes in the treatment of malignant medulloblastoma., Downregulation of urokinase plasminogen activator receptor leads to induction of papillary thyroid carcinoma cell senescence., urokinase-type plasminogen activator is overexpressed in pterygia and pterygium fibroblasts, DEP-1 (density enhanced phosphatase-1/CD148), which is abundantly expressed in confluent endothelial cells, inhibited the VEGF-dependent activation of ERK1/2, leading to down-regulation of uPAR expression, Soluble UPAR was associated with subclinical organ damage, but predicted cardiovascular events independent of subclinical organ damage and traditional risk factors., We found a significant correlation of HER2 with human epidermal growth factor receptor 3 (HER3/erbB3), epidermal growth factor receptor 1 (EGFR/HER1/erbB1) and urokinase plasminogen receptor (uPAR) in breast cancer tissues., miR-10b induced glioma cell invasion by modulating tumor invasion factors MMP-14 and uPAR expression via the direct target HOXD10, The targeting uPAR not only inhibited established intracranial tumors but also radiation-induced recruitment of endothelial cells and monocytes towards the tumor region., uPAR forms are promising prognostic and predictive markers in prostate cancer., There was no statistically significant difference in serum uPAR levels between the patients with Behcet's disease and the control subjects., uPAR expressed on neutrophil plasma membrane regulates transendothelial migration., Concentrations of urokinase plasminogen activator (uPA) in induced sputum of asthma patients after allergen challenge., differential binding and signalling between the cleaved and uncleaved forms of kininogen, This work provides a first direct demonstration of the dimerization of uPAR in live cells, and provides the first methodoligcal guide on number and brightness analysis to discern minor changes in molecular composition., These data shed light on a molecular mechanism whereby acquisition of uPAR expression may modulate oral squamous cell carcinoma invasive activity through alteration of focal adhesion dynamics., There is a negative prognostic influence of the expression of CD87 on the surface of acute myeloid leukemia blasts, Results suggest that PAI-1 and uPAR-del4/5 mRNA levels may add prognostic information in STS patients with R0 status., increased expression in sinonasal mucosa of chronic rhinosinusitis patients with polyps, High U-PAR expression is associated with poor treatment response in colorectal carcinoma., No association between uPAR (rs344781) polymorphism and endometrial carcinoma risk, The inherent interdomain mobility in uPAR plays a major role in modulating its function., Endothelial progenitor cell-dependent angiogenesis requires localization of the full-length form of uPAR in caveolae., Circulating urokinase receptor is a cause of focal segmental glomerulosclerosis., These results indicate that urokinase plasminogen activator, plasminogen activator urokinase receptor and maspin expression patterns may be useful markers for evaluating the clinical course or prognosis of oral squamous cell carcinoma patients, Cathepsin B and uPAR downregulation reduced tumor growth and increased p27 nuclear expression in vivo., Neither UPARwt, nor UPAR-del4/5 nor RAB31 mRNA expression levels were found to be prognostic markers in advanced ovarian cancer., Data show that uPAR and its crosstalk pathways with EGFRvIII emerge as logical targets for therapeutics development in GBM., serum levels of suPAR, a component of the fibrinolytic cascade, are strongly associated with progressive liver fibrosis in HCV infection., Data suggest that combination treatment with radiation and uPAR knock down or Chk2 inhibitor resulting in non-reversible G2/M arrest may be beneficial in the management of meningiomas., down regulation of uriokinase plasminogen activator (uPA) or uPA receptor results in the inhibition of glioma cell invasion via inhibition of Notch 1 receptor cleavage, signaling and endosomal trafficking of the Notch 1 receptor, Data argue for a biological relevance of the interdomain dynamics of the glycolipid-anchored uPAR on the cell surface., uPAR, a glycosylphosphatidylinositol-anchored cell-surface receptor family member, undergoes ligand-induced internalization and nuclear transport in vascular smooth muscle cells., Serum suPAR is a potential novel biomarker for the diagnosis of cirrhosis, identification of alcoholic origin and for determining prognosis in patients with chronic liver disease., Africans had higher levels of soluble UPAR and arterial stiffness than Caucasians (p<0.001), but there was no independent relationship between arterial stiffness and soluble UPAR in the Africans., Elevated levels of soluble UPAR are, independently of established cardiovascular risk factors, associated with an increased incidence of CVD in elderly subjects., The uPAR pathway is required for efficient epithelial wound repair. Increased uPAR expression, leads to weak wound repair which may contribute to the development and progression of airway remodelling in asthma., Small hairpin RNA against uPA and/or uPAR increased secretion of TIMP-1, which is known to enhance SVEGFR1 secretion in endothelial cells and glioblastoma cells., Resveratrol reduces TNF-alpha-induced U373MG human glioma cell invasion through regulating NF-kappaB activation and uPA/uPAR expression, uPAR is an essential component of the network through which VEGF controls integrin redistribution and endothelial cell migration., Simvastatin and atorvastatin attenuate VCAM-1 and uPAR expression on human endothelial cells and platelet surface expression of CD40 ligand., uPAR is dispensable for nerve development, whereas, loss of uPAR affects nerve regeneration., uPAR rapidly activated RhoB and increased RhoB expression., Plasma levels of PLAUR, but not C-reactive protein, is robustly and significantly related to the extent of carotid plaques in atherosclerosis., uPA, uPAR, and PAI-1 were quantified by enzyme-linked immunosorbent assay (ELISA) in extracts of 226 breast tumor biopsies., The downregulation of uPA/uPAR results in increased integrin alphavbeta5 cell-surface protein levels that regulate the activity of beta1 integrins, promoting characteristics of the persistent Myofibroblasts., We have identified three potential invasive markers, uPA, MMP-1 and IL1-R1, whose gene expression may differentiate PDAC from other pancreatic neoplasms., our studies indicated that uPAR plays a significant role in ovarian cancer, suPAR does not seem to be a useful biomarker in the AAA disease., In papillary thyroid carcinoma BRAFV600E is associated with increased expression of the urokinase plasminogen activator and its cognate receptor, but not with disease-free interval., A transgenic mouse C-type lectin domain family 9 (Clec9A)-diphtheria toxin receptor is developed that allows ablation of in vivo Clec9A-positive dendritic cells., urokinase receptor (CD87) represents a central mediator of growth factor-induced endothelial cell migration, A flexible multidomain structure drives the function of the urokinase-type plasminogen activator receptor (uPAR)., The detrimental effects of atherogenic LDL on VSMC are mediated by a decrease and delocalization of the UPA-UPAR interaction that result in an impairment of cytoskeleton dynamics and adhesion capacity affecting cell phenotype and function., Higher levels of CD87 were associated with increased risk for cardiovascular disease compared to the lower levels., apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma, Multivariate survival analysis demonstrated that high levels of uPAR(I) were significantly associated with short overall survival in small cell lung cancer patients, Data suggest that soluble urokinase plasminogen activator receptor (suPAR) might be an objective marker for identifying systemic lupus erythematosus (SLE) patients with active disease., Ser90 is a critical residue for urokinase receptor-modulated cell migration and invasion signaling., Simultaneous knockdown of both MMP-9 and uPAR regulated a majority of the molecules associated with glioma cell migration and significantly reduced the migration potential of glioma cells., Concentration of soluble urokinase-type plasminogen activator receptor is significantly increased in the blood of patients with pelvic inflammatory disease., Given the importance of FOXM1 in regulation of the expression of genes key to cancer biology, dysregulated expression and activation of FOXM1 may play important roles in colon cancer progression and metastasis., role in the pathogenesis of focal segmental glomerulosclerosis, Soluble uPAR in human carotid plaques and plasma is associated with the presence of symptoms and that plaque suPAR is associated with the vulnerable inflammatory plaque., A novel role in doxorubicin-induced vascular damage via VSMC senescence is played by uPAR, which controls telomere function mediated by TRF2. uPAR affects TRF2 via Siah1-mediated ubiquitination & downregulation of proteasomal degradation., Single nucleotide polymorphisms in the RXRA and PLAUR genes in the vitamin D pathway may contribute to breast cancer disease free survival., Downregulation of uPAR and cathepsin B quenched TGF-beta1-driven invasion and survival of meningioma cells in a XIAP-dependent manner., Highlighted the importance of uPAR and cathepsin B in the regulation of malignant stem cell self-renewal through hedgehog components, Bmi1 and Sox2., UPAR, whose expression is regulated by uPA, can, in turn, regulate uPA expression through a mechanism involving its functional interaction with integrins and fMLF-Rs., Importance of vitronectin and its interaction with the urokinase receptor in tumor growth., Elevated levels of the urokinase plasminogen activation receptor is associated with highly aggressive breast cancer., Report role of urokinase plasminogen activator receptor in orchestrating the effects of plasminogen system on airway epithelial cell function., Plasma PLAUR levels were significantly elevated in focal segemental glomerulosclerosis but did not distinguish primary from secondary disease., sLR11 regulates the hypoxia-enhanced adhesion of HSPCs via an uPAR-mediated pathway that stabilizes the hematological pool size by controlling cell attachment to the BM niche., Higher soluble urokinase plasminogen activator receptor (PLAUR) levels indicate a poorer prognosis in gastric cancer patients., NT-proBNP, CRP and suPAR levels were higher in black compared to white men, Deacetylated GM3 enhances the metastatic phenotype by activating p38 signaling through uPAR/integrin signaling with FAK, PI3K, and Src kinase as intermediates., PAI-1 and uPA expressions were changed in opposite directions in high invasive prostate cancer cell lines resulting in a strong decrease of PAI-1/uPA ratio., suPAR may help the objective assessment of asthma control, since it correlates with airway resistance and has good sensitivity in the detection of impaired asthma control., Overexpression of splice variant UPAR-del4/5 leads to reduced cell adhesion and invasion in breast cancer cells in a dose-dependent manner., Novel nonproteolytic signaling pathway initiated by single chain urokinase and mediated by domain 2 of uPAR, beta1-integrins, and VEGF receptor 2 leads to angiogenesis., Studied serum and urine soluble uPAR from pretransplantation banked samples from 86 well-characterized kidney transplant recipients and 10 healthy controls to determine its prognostic utility., suPAR is an important biomarker that can predict infections in the early stage of febrile neutropenia with high sensitivity and NPV for patients with hematologic malignancies., The reduced levels of Lp-PLA2 and suPAR in human carotid plaques of subjects on long-term treatment with beta-blockers suggest their possible protective role in plaque inflammation., A uPAR-dependent signaling pathway is required for CSE-induced EMT, which contributes to small airway fibrosis in COPD., suPAR and the non-specific inflammatory markers CRP and PCT may have roles in development of community acquired pneumonia in children, Podocyte effacement is the first pathologic manifestation of FSGS after transplantation. The degree of podocyte effacement correlates with suPAR levels at time of diagnosis., Elevated level of uPAR is detected in various aggressive cancer and contributs to tumor cell invasion and metastasis. [review], Soluble urokinase plasminogen activator receptor was identified in a majority of patients with focal segmental glomerulosclerosis as a soluble factor that acts through binding to and activating podocyte beta 3 integrin., We found no association between allele frequency and risk of multiples sclerosis for any single nucleotide polymorphism investigated for PLAUR, HIV-1 infected lymphoid organs upregulate expression and release of the cleaved form of uPAR that modulates chemotaxis and virus expression., RERF(urokinase receptor-derived peptide ) is a promising therapeutic agent for the control of diseases fuelled by excessive angiogenesis such as cancer., The uPAR-C5aR axis, via the underlying NFkappaB transcriptional program, controls osteogenic differentiation with functional impact on vascular calcification in vivo., The uPA/uPAR angiogenesis regulatory system supports the endothelial cells that need to migrate, invade the extracellular matrix, survive, proliferate, and to re-establish new contacts with cells and the surrounding matrix. (Review), Genome-wide protein QTL mapping identifies human plasma kallikrein as a post-translational regulator of serum uPAR levels., uPAR is associated with increased occurrence of carotid plaque and increased incidence of ischemic stroke, MMP-9/uPAR overexpression enhanced the potential of glioma cell migration and invasion., UPAR expression renders cell migration totally., uPAR(I-III) + (II-III) is of prognostic significance in inoperable cholangiocarcinomas., Intrahepatic uPAR activation and serum suPAR concentrations might serve as an interesting biomarker in acute liver failure., Soluble urokinase plasminogen activator receptor is a sensitive and specific independent predictive biomarkers in preterm babies with bronchopulmonary dysplasia., the expression of the urokinase receptor isoform exons uPAR (D1D2) increases from normal liver cells, liver cells to para-carcinoma cells., Data indicate that alpha5beta1 integrin is recruited to lipid rafts through interactions with urokinase-type plasminogen activator receptor (uPAR)., Suggest a possible protective effect of podocyte uPA/uPAR expression against interstitial fibrosis in IgA nephritis., uPAR mediates efferocytosis through high molecular weight kininogen interaction with phosphatidylserine on apoptotic cells, Overexpression of uPAR and cathepsin B increases expression of cytosolic p-JNK., There is a significant association between uPAR rs344781 gene promoter polymorphism and migraine without aura susceptibility but not with headache severity in Iranian patients., This study demonstrates a significant independent negative association between colorectal cancer patient survival and uPAR expression in especially tumor-associated stromal cells., uPAR promotes nasopharyngeal carcinoma cell growth and metastasis in vivo., Results suggest that Gal-3 modulates uPAR expression via the MEK/ERK pathway in hepatocellular carcinoma cells., The mRNA expression levels of uPA, its receptor (uPAR), and its inhibitor type 1 (PAI-1) were analyzed in corresponding malignant and adjacent nonmalignant tissue specimens from 132 PCa patients by quantitative PCR., soluble urokinase-type plasminogen activator receptor is expressed in term neonates with infection or sepsis, Serum uPAR levels correlate with overall survival in colorectal adenocarcinoma., In vascular smooth muscle cells (VSMC) U-PAR activates DNA single strand break repair signaling pathway., uPAR and PAI-1 are potential predictive biomarkers in early stage oral squamous cell carcinomas, Increased levels of fibulin-1 were independently associated with higher levels of suPAR and NT-proBNP especially in patients with lower aortic valve stenosis, Inhibition of uPAR could sensitize HCT116 to TRAIL-induced apoptosis., these data suggest that uPAR and CXCR4 co-expression predicts worse prognosis of small cell lung cancer patients, The main goal of this study was to evaluate the serum soluble urokinase-type plasminogen activator level in stable chronic obstructive pulmonary disease patients compared with a control group., Patients with schizophrenia had significantly higher soluble urokinase-type plasminogen activator receptor levels than healthy controls., The interaction between uPAR and vitronectin triggers ligand-independent adhesion signalling by integrins., Synergy of uPAR mRNA and integrin alpha5beta1 interaction may result in abnormal signal transduction in liver cells and ultimately liver cell abnormal clonal hyperplasia and malignant transformation., Findings suggest a novel function of HSP70/MRJ/uPAR complex in cell adhesion, invasion and migration, and may provide more understanding in the mechanisms of uPAR-mediated cancer metastasis., Elevated serum suPAR levels are associated with reduced eGFR and presence of proteinuria in both primary and secondary glomerulonephritis., expression and release, from osteoblasts of macrophage colony-stimulating factor (M-CSF), which is indispensable for osteoclast differentiation, was inhibited by uPAR loss., our results show, for the first time, that eEF-2K is involved in regulation of the invasive phenotype of PaCa cells through promoting a new signalling pathway, which is mediated by TG2/b1 integrin/Src/uPAR/MMP-2, Soluble urokinase plasminogen activator receptor, but not high-sensitive C-reactive-protein, might have a role in coronary artery calcifications in healthy middle-aged subjects, found that miR-10b induced HCC cell invasion and migration by modulating the HOXD10 target gene RhoC, uPAR, MMP-2 and MMP-9 expression, uPA/uPAR stimulates triglyceride synthesis in Huh7 hepatoma cells via p38-dependent upregulation of DGAT2, uPAR has a role in inducing expression of TGFbeta and interleukin-4 in cancer cells to promote tumor-permissive conditioning of macrophages, Following GM1 exogenous addition, the GM3 compartment is depleted of uPAR which is recruited within caveolar rafts thereby triggering angiogenesis, The soluble UPAR level was significantly higher in children with a severe course of pneumonia., Unique sites of interaction between alphavbeta6 and uPAR are most likely located in uPAR domains II and III., Soluble uPAR can serve as a biomarker for diagnosing sepsis and assessing disease severity., High suPAR levels are associated with an increased risk for both previous and future use of antidepressants in healthy men and women., Polymorphisms in this fibrinolytic system gene are associated with recurrent spontaneous abortion in Sinhalese women, probably through impaired implantation., Extracellular matrix biomarker, fibulin-1 and its association with soluble uPAR in a bi-ethnic South African population, Cigarette smoke elevates soluble plasminogen activator urokinase receptor isoforms in bronchial epithelial cells through direct (cleavage) and indirect (messenger RNA expression) means, S- and u-suPAR after therapy may serve as clinical markers to judge the treatment response of untreated nephrotic syndrome and differentiate, The above preclinical findings strongly suggest that uPAR retargeted measles virotherapy is a novel and feasible systemic therapy strategy against metastatic breast cancer., Silencing of ETV4 suppresses invasion of prostate cancer cells by inhibiting the expression of uPA/uPAR as well as (MMP)-2 and MMP-9, plasma suPAR level is an independent predictor of coronary microvascular function, expression of uPAR is a possible prognostic marker that could be useful in identification of patients with aggressive, highly invasive urothelial neoplasia of the bladder, In patients with gastrointestinal cancer the level of suPAR is high, with highest values in advances disease with remote metastases. Hhighest levels were found in patients with IV stage who underwent palliative therapy., uPAR(+) cells injected subcutaneously into nude mice markedly increased tumor growth, induced VM formation and liver metastasis; by contrast, uPAR(-) cells did not., Results show that higher plasma uPAR levels were associated with shorter progression-free survival and overall survival of patients with metastatic colorectal cancer (mCRC) suggesting that uPAr is an independent prognostic biomarker for mCRC., Epithelial and stromal cell urokinase plasminogen activator receptor expression differentially correlates with survival in rectal cancer stages B and C patients, suPAR levels at 6/36 hours after cardiac arrest were significantly higher in nonsurviving patients compared with survivors; however, the overlap in suPAR levels between the outcome groups was substantial, reducing the prognostic value., REVIEW, suPAR is a marker of acute inflammation and can be used as predictor of acute exacerbation in COPD., Soluble urokinase plasminogen activator receptor predicted both all-cause and cardiovascular mortality in a South African black population., results suggest that suPAR may function as an important paracrine signaling factor in EGFRvIII-positive GBMs, inducing an aggressive phenotype in tumor cells that are EGFRvIII-negative, In HEK 293 cells, transfected with human uPAR, uPAR overexpression down-regulates PTEN and activates the PI3K/Akt-pathway., data on the stromal macrophages immunoreactivity of uPAR, MMP-2, and MMP-9 in a few small cell lung cancer (SCLC) and lung squamous cell carcinoma (SCC) biopsies was included. uPAR, MMP-2, and MMP-9 were confirmed in stromal cells including macrophages, micrornas directly target the 3'untranslated region of both uPAR- and CXCR4-mRNAs., uPAR/suPAR is elevated in most kidney diseases., Results found high levels of uPA and uPAR exclusively in metastatic osteosarcoma (OS)cells and suggest that malignant conversion of OS cells to uPA/uPAR axis in an autocrine and paracrine fashion., In patients with IgA nephropathy, the plasma suPAR levels were associated with age, gender, renal function, the degree of tubular atrophy/interstitial fibrosis and the percentage of crescent formation., Human uPAR activation and its association with beta1-integrin are required for PDGF-AB-induced migration., Both the depressed patients and suicide attempters had increased plasma soluble form of the urokinase receptor (suPAR). The levels of suPAR discriminated better between controls and suicide attempters than did C reactive protein., High cytoplasmic expression of uPAR is associated with cells of rectal cancer and metastases of perienteric lymph nodes., our data show that uPAR is required for efficient skin tumor formation, uPAR-VEGFR2 interaction is crucial for VEGF signaling in endothelial cells, There was no statistically significant difference in the plasma SuPAR levels of psoriasis patients compared to the control group., The present paper develops a mathematical model of cancer recurrence besed on UPAR serum concentration.,
SP_COMMENT function:Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form., similarity:Contains 3 UPAR/Ly6 domains., subunit:Monomer (Probable). Interacts with MRC2.,