Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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plasminogen activator, urokinase(PLAU) plasminogen activator, urokinase(PLAU) Related Genes Homo sapiens
CHROMOSOME 10,
CYTOBAND 10q24,
ENSEMBL_GENE_ID ENSG00000122861,
GENERIF_SUMMARY Pleiotrophic inhibition of pericellular urokinase-type plasminogen activator system by endogenous tumor suppressive maspin., Cooperativity between the Ras-ERK and Rho-Rho kinase pathways in urokinase-type plasminogen activator-stimulated cell migration, Exposure of cryptic domains in the alpha 1-chain of laminin-1 by elastase stimulates macrophages urokinase and matrix metalloproteinase-9 expression., TPA & urokinase progressed to maximum levels in late pregnancy, but decreased in labor, favoring a coagulation state despite elevated D-dimer levels suggesting enhanced fibrinolysis., significant decresase in PBM uPA activity in HIV infected and immunosuppresed patients independent from the presence of P. carinii lung infections, Substitution of the two relevant serines with glutamic acid residues impairs the ability of urokinase to mobilize a variety of human and mouse cell lines as well as human primary T lymphocytes., bFGF up-regulated UPA in both normal and dystrophic myoblasts and weakly upregulated UPA receptor in normal satellite cells., Random peptide bacteriophage display used as a probe to identify urokinase receptor binding sites other than the binding site of UPA residues 1-48., In a study of the differential role of UPA and TPA as inducers of fibronectin mRNA, UPA led to an increase of FN mRNA expression in early G1, did not lead to FN assembly in the ECM, induced monomric FN, Coculture of monocytes and vascular smooth muscle results in 5-fold increase in UPA expression in monocytes, resulting in VSMC migration., Osteopontin modulates prostate carcinoma invasive capacity through RGD-dependent upregulation of UPA., Protease activity, growth factor-like and kringle domains of uPA differentially contribute to activation of p42/p44erk1,2 and p38 MAP-kinases., Endogenous UPA is not only overexpressed in smooth muscle cells upon stimulation with PDGF/bFGF, but also mediates the mitogenic activity of the growth factors in a catalytic-domain-dependent manner., possible role of fibroblast growth factors in expression of genes of the plasminogen activator system in breast fibroblasts, Structural analysis of the interaction between urokinase-type plasminogen activator and its receptor, Diagnostic significance of measurement of the receptor for urokinase-type plasminogen activator on granulocytes and in plasma from patients with paroxysmal nocturnal hemoglobinuria., interaction with urokinase receptor mediates inhibitory signal for HIV-1 replication, expression of uPA and uPAR is associated with the clinical behaviour of bladder neoplasms, Increased expression of urokinase during atherosclerotic lesion development causes arterial constriction and lumen loss, and accelerates lesion growth., Characterization of the binding of human urokinase-type plasminogen activator to the asialoglycoprotein receptor of rat liver, Urokinase plasminogen activator receptor could be associated with BBB disruption and with promotion of CNS invasion by chemotactically active cells, macromolecules, and microbes., upregulation of PAI-1, uPA, and tPA after long-term LDL exposure seems to be mediated by a delayed PKC activation associated with an increased PA inhibitory activity, the circluating level and its soluble receptor (suPAR) are not up-regulated by the circulating P105 fraction of the HER-2/neu proto-oncogene, the role of urokinase in the regulation of monocyte/macrophage functions, such as that occurring in inflammatory reactions, There was a positive correlation between uPA and PAI-1 antigen levels and clinicopathological parameters such as grade (p < 0.001 and p = 0.01, respectively), uPA mrna stability is maintained through shuttling of uPA mRNABp between the nucleus and cytoplasm, u-PA present on the platelet surface interacts with u-PAR on the endothelial cell and induces u-PA synthesis in the vascular enodthelial cell., promotion of mRNA stability in invasive brease cancer cells by Rac1-MKK3-p38-MAPKAPK2 pathway, recognition of uPA by alpha(M)beta(2) allows for formation of a multicontact trimolecular complex, in which a single uPA ligand may bind to both uPAR and alpha(M)beta(2); interaction of uPA with each receptor influences cell adhesion and migration, C/C genotype in exon 6 of uPA gene can be further considered as being related to colorectal cancer progression., Syk, a protein-tyrosine kinase, suppresses the cell motility and nuclear factor kappa B-mediated secretion of this enzyme by inhibiting the phosphatidylinositol 3'-kinase activity in breast cancer cells., recombinant kringle domain has anti-angiogenic activity, small, hormone-receptor-positive breast cancers (with a theoretical good prognosis) may carry an elevated risk of nodal involvement if accumulation of uPA-PAI-1 complexes is shown inside their tumour cells by means of immunohistochemistry., Human/chicken chimeric uPA molecules & point mutants revealed the structural requirements for uPA autoactivation vs zymogen stability. The amino terminal fragment of chicken uPA engineered onto the human uPA molecule induces human uPA autoactivation., PDGF and similar cytokines may be important factors in airway remodeling by redistribution of smooth muscle cells during inflammation and that urokinase may be important in potentiating the response., Induction of PAI-1 by exposure of lung epithelial cells to uPA is a newly recognized pathway by which PAI-1 could regulate local fibrinolysis in lung inflammation or neoplasia, High expression of Urokinase-type plasminogen activator is associated with melanoma, uPA regulates uPAR expression in NSCLC at a posttranscriptional level by increasing uPAR-stability through a cellular factor that binds the coding region of uPAR-mRNA, The expression of uPA was significantly correlated with depth of gastric tumor invasion, differentiation, lymphatic and vascular invasion., tPA and plasma kallikrein-mediated uPA activation and tPA release contribute to endogenous fibrinolytic or thrombolytic mechanisms., evidence that the small GTPases RhoA and Rac1, but not Cdc42, are directly associated with Tyk2 and PI3-K in an uPA/uPAR-dependent fashion and are necessary to mediate the uPA/uPAR-directed migration via the Tyk2/PI3-K signalling complex in human VSMC, Plasma uPA levels are greater in those with bladder cancer than in healthy subjects (P <0.001); for patients with bladder cancer, a greater preoperative plasma uPA level was an independent predictor of poor outcome after radical cystectomy., A high cytosol value of this enyme may be predictive of early relapse in primary breast cancer., increased expression of urokinase-type plasminogen activator(uPA) may initially lead to degradation of amyloid beta-protein but chronic expression of uPA and plasminogen activation led to loss of cerebrovascular smooth muscle cell attachment, The urokinase-type plasminogen activator (uPA)-plasmin cascade is involved in the activation of astrocyte pro-MMP-2 in glioma-astrocyte coculture that leads to the increased invasiveness of glioma cells in the central nervous system., first report that osteopontin induces nuclear factor kappaB activity and urokinase secretion by activating phosphatidylinositol 3'-kinase/Akt protein/Ikappab kinase-mediated signaling pathways, Methylation status of uPA promoter regulates prostate cancer invasion and growth., The increase in antigenic levels of uPA and MMP-3 in endometrium of women with endometriosis might contribute to the invasive potential of endometrial cells, data indicating that the structure of the kringle as well as its interaction with the growth factor domain govern urokinase binding to the urokinase receptor, the promoter activity of uPA is enhanced in gastric tumor cells by p38 MAPK, PLAU is a promising new candidate gene for late-onset Alzheimer's disease, with allele C (P141) being a recessive risk allele or allele T (L141) conferring protection., Increased expression of u-PA is a feature of bone metastasis in patients with prostate cancer., confirm the role of uPA in acantholysis and suggest an involvement of IL-1alpha/TNF-alpha in uPA induction, TAFIa inhibited lysis of model thrombi and plasma clots by uPA, scuPA and tPA, which could be partially overcome by plasminogen, consistent with TAFIa exerting its effect through modifying the binding of plasminogen and tPA to fibrin., predictors of human immunodeficiency virus (HIV) disease progression (review), No significant increases in uPAR were found in pretreatment determinations of patients with advanced small-cell lung cancer or non-small-cell lung cancer., urokinase and urokinase receptor mRNAs are stabilized by HuR linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2, uPA and uPAR are up-regulated during acute renal allograft rejection, nuclear factor kappaB-mediated secretion of urokinase type plasminogen activator is regulated by p56lck through tyrosine phosphorylation of IkappaBalpha following hypoxia-reoxygenation, uPA is upregulated by TGF-beta1 and PI3 kinase in human tumor cells, Increased uPa hydrolysis was associated with endometriotic lesion in patients diagnosed with endometriosis., secretion is induced by osteopontin inducing AP-1 through c-Src-dependent epidermal growth factor receptor transactivation in breast cancer cells, uPA, suppression of activation of receptor-bound pro-urokinase leads to downregulation of matriptase and inhibition of tumor invasion, assembly of Plg and uPA on integrin alpha(M)beta(2) regulates Plm activity and, thereby, plays a crucial role in neutrophil-mediated thrombolysis, uPA and PAI-1 have roles in progression and recurrence of breast cancer [review], urokinase-type plasminogen activator (uPA) and type-1 inhibitor (PAI-I) complex has a role in breast cancer resistance to endocrine therapy independent of steroid hormone receptor status, MMP-13, uPA, and PAI-1 antigen levels were determined in the synovium of patients with osteoarthritis, The urokinase gene 3'-UTR "T" allele was associated with rheumatoid arthritis in Chinese patients in Taiwan., investigated whether the increase of uPA monocyte expression and chemokine releases induced by oxidised low density lipoproteins involved proinflammatory phospholipid products having platelet-activating factor-like activity via the PAFR pathway, u-PA down-regulation by RNAi technology decreases the invasive capability of hepatocellular carcinoma cells, NF-kappaB dysregulation and uPA overexpression have roles in a more aggressive tumor behavior in hepatocellular carcinoma, and IKKbeta plays a critical role in the HBx-activated NF-kappaB signaling pathway, Endothelial uPA expression is flow sensitive and differentially regulated by laminar and turbulent shear stress in vitro. This effect may contribute to local nature of atherosclerosis., Data describe the cyclic variation and distribution of urokinase plasminogen activator (uPA), uPA receptor and plasminogen activator inhibitor 1 (PAI-1) mRNA in normal endometrium., Patients with mitral valve prolapse have a higher frequency of PLAU polymorphism among the chinese population in Taiwan., uPA/uPAR ligation anchors the complex to the actin cytoskeleton and is a part of the mechanism responsible for uPA-induced cell migration in fibroblasts., The urokinase gene 3'-UTR "T" allele is associated with oral cancer in humans, and may play a role in oral cancer formation., participates in endothelial cell migration under regulation of p38 MAPK pathway, Increased expression of urokinase-type plasminogen activator is associated with transitional cell carcinoma of the human bladder, Urokinase (uPA) is a potent chemoattractant for basophils that seems to act through exposure of the chemotactic uPA receptor epitope uPAR84-95, which is an endogenous ligand for formyl peptide receptor (FPR)-like 2 (FPRL2) and FPRL1., uPA mRNA and uPAR mRNA expression were found in 9 and 8 of prostsatic adenocarcinomas, respectively, and in 7 and 6 of benign prostatic hyperplasias., Polymorphisms are not associated with late onset Alzheimer's disease., sesamol increased the production of uPA and tPA significantly and also up-regulated the mRNA expressions of these proteins., VEGF and PAI-1 interact and may have roles in progression of node-negative breast cancer, the G(i)-Ras-Raf-NF-kappaB signaling cascade is responsible for LPA-induced uPA up-regulation in ovarian cancer cells, expression and assembly of uPAR co-receptors in a specific cell type determines the response to uPA, basic capacity of separated epithelial and stromal cells from all three types of tissue to release uPA, PAI-1, and suPAR without any paracrine influence, as in vivo, IGF-I and HGF cooperate to induce migration and invasion of colorectal carcinoma cells, and c-Met and uPA/uPAR are required for IGF-I-mediated migration and invasion., sphingosylphosphorylcholine may affect angiogenesis in the wound-healing process via regulation of uPA production, Our results suggest that PBK1 is involved in the regulation of uPA expression, which might provide a new clue to further understanding the regulation mechanism of uPA expression., expression and regulation of uPA mRNA. This pathway may regulate uPA-mediated functions of the lung epithelium in the context of inflammation or neoplasia, The level of urinokinase-type plasminogen activator (u-PA) does not correlate with cerebrospinal fluid to serum albumin ratio, suggesting an unimportant role for uPA in HIV-induced blood-brain-barrier disruption., Epidermal growth factor modulates prostate cancer cell invasiveness by regulating urokinase-type plasminogen activator activity, p53 is induced by urokinase in lung epithelial cells, the urokinase-type plasminogen activator (uPA) induces, via its specific receptor (uPAR, CD87), upregulated expression of the complement anaphylatoxin C5a receptor, uPA processes recombinant latent platelet-derived growth factor D into the active form., results demonstrate that endogenous HMW uPA inhibits S. aureus growth both directly, by cytolysis, and indirectly, by abrogation of the neutralizing effect of staphylokinase on the bactericidal activities of human neutrophil peptides, decrease in uPAR mRNA and protein concentrations caused by DNA enzymes significantly suppressed Saos-2 cell invasion as assessed by an in vitro Matrigel assay, Urokinase-type plasminogen activator is overexpressed in renal cell carcinoma and could function as tumour marker., the uPA gene contains a novel 13-bp palindrome that contains the DNA consensus-binding hexamer for RUNX1, Elevated plasma levels in, and therefore a marker for cancers., a complex signaling network operating downstream of uPA-uPAR actively advances tumor cell invasion, proliferation, and survival of prostate cancer cells, Induced-sputum innate immune factor levels discriminate inflammatory changes in cystic fibrosis, COPD, and asthma., Both wild-type (wt) and human cleavage resistant-uPAR are able to mediate uPA-induced migration, are constitutively associated with the EGFR, and associate with alpha3beta1 integrin upon uPA binding, crystal structure at 1.9 angstroms of the urokinase receptor complexed with the urokinase amino-terminal fragment and an antibody against the receptor, the urokinase/PAI-2 complex is a new high affinity ligand for the endocytosis receptor low density lipoprotein receptor-related protein, data provide evidence for a novel pathway of fibronectin matrix assembly through the uPAR-dependent sequential activation of Src kinase, EGFR, and beta1 integrin, IL-1alpha can induce selective upregulation of alpha6beta1-integrin and uPA/uPAR in pancreatic cancer cells and these changes may modulate the aggressive functions of pancreatic cancer., The T allele of 3' UTR of the urokinase gene may not be associated with a higher risk of stone formation., Results clearly suggest the involvement of the uPA-uPAR system in cell survival and proliferation in addition to their role in tumor progression., urokinase plasminogen receptor domain III controls a functional association with alpha5beta1 integrin and tumor growth, endothelial progenitor cells are characterized by high intrinsic uPA/uPAR-dependent proteolytic potential that could contribute to their invasive and angiogenic behaviour, In adult alphaMUPA mice (uPA transgenic) the incisor teeth display discoloration and tip fragility, and reduction of the outer enamel as determined by scanning electron microscopy., incubation of retinal pigment epithelial cells with uPA elicits a time-dependent enhancement of MAPK and phosphatidylinositol 3-kinase activities as well as the transcriptional activation of Bcl-xL anti-apoptotic factor, Intratumoral injections of the plasmid vector expressing siRNA for uPA resulted in regression of pre-established, subcutaneous meningioma tumors., Effects induced by exogeneous addition of domain-specific uPA antibodies and uPA-interacting molecules on proliferation of uPA-suppressed MDA-MB-231 breast cancer cells., Constitutive uPA primes, and exogenous uPA can activate, airway eosinophil adhesion following segmental allergen challenge and that increased uPA expression may be a mechanism of increased eosinophil infiltration and function in asthma., Native electrophoresis and SDS-PAGE showed multiple protein bands corresponding to different forms of the urokinase, which were confirmed by Western blotting and zymography., down-regulation of matriptase expression in THP-1 cells by siRNA reduced the activation of cell-associated pro-uPA and the subsequent rapid initiation of plasminogen activation, preliminary crystallographic analysis of amino-terminal fragment, Lipoprotein receptor-related protein -mediated clearance of uPA is one of the mechanisms involved during the control of human thyroid carcinoma cell invasion., Evidence of a genetic and functional involvement of a common PLAU variant into the pathogenesis of Alzheimer Disease., Methylation of the uPA promoter leads to loss of uPA gene expression in laryngeal squamous cell carcinoma., review of the expression of the plasminogen activator system in endometriosis, urokinase-type plasminogen activator (uPA) and its soluble receptor may not have roles in progression of atopic eczema/dermatitis syndrome, as plasma levels of uPA and suPAR are similar in patients at different stages of AEDS and healthy subjects, the ability of hepsin to efficiently activate pro-uPA suggests that it may initiate plasmin-mediated proteolytic pathways at the tumor/stroma interface that lead to basement membrane disruption and tumor progression, study shows uPA & uPAR are overexpressed in primary prostate cancer cells & surrounding stromal cells (Gleason score >/=7) & more than 90% lymph node metastases but not in normal prostate, benign prostate hyperplasia or prostatic intraepithelial neoplasia, distribution of four tagSNPs (rs2227562 in intron 5, rs2227564 in exon 6, rs2227571 in intron 9, and rs4065 in 3'UTR) in the PLAU gene in a large case-control study of Alzheimer's disease, autotaxin induces uPA expression via the Gi-PI3K-Akt-NF-kappaB signaling pathway that might be critical for autotaxin-induced tumor cell invasion and metastasis, uPA gene regulation by c-phycocyanin (c-pc) is transcriptionally controlled through cAMP mediated PKA pathway., plasmin-mediated apoptosis of VSMC occurs via plasminogen activation by either t-PA or u-PA and is impaired by PAI-1., The blood concentrations of soluble urokinase-type plasminogen activator (uPAR) and mannan-binding lectin (MBL) are related to the risk of postoperative infectious complications., Our results showed that the subcutaneous injection of small interfering RNAs (siRNA) u-PA SKHep1C3 stable transfected cells (pS siRNA u-PA) led to a growth delay in xenograft development., role for PLAU_1 as an independent genetic risk factor for Alzheimer disease in the Italian population for those subjects who do not have the APOE-epsilon4 allele, This study suggests that ILK serves as a key mediator in TGFbeta1 regulation of uPA/PAI-1 system critical for the invasiveness of human ovarian cancer cells. And ILK is a potential target for cancer therapy., Urokinase gene 3'-UTR polymorphism associated with prostate cancer., LRP is expressed in colorectal cancer and forms complexes with u-PA and its inhibitor, alpha2-antiplasmin induction inhibits E-cadherin processing mediated by the plasminogen activator/plasmin system, leading to suppression of progression of oral squamous cell carcinoma via upregulation of cell-cell adhesion, The expression of p-p38 and uPA was negatively correlated to prognosis of breast cancer., recombinant kringle domain inhibits the malignant glioma growth by suppression of angiogenesis, uPA may play a critical role in ligation-induced vessel remodeling, PAI-3, but not PAI-1 or uPA, may have a role in breast cancer survival by suppression of tumor invasion through protease inhibition in stroma, Elevation of plasma uPA and uPAR levels in CaP patients are partly caused by local release from the prostate. Plasma levels of uPA and uPAR are associated with biologically aggressive CaP, disease progression after radical prostatectomy, and metastasis, The production of matrix metalloproteinases (MMPs), tissue inhibitors of MMPs, and plasminogen activators by gingival fibroblasts stimulated with lipopolysaccharides produced by periodontopathogens, are reported., Upregulation of urokinase type plasminogen activator (UroPA) expression during early development of knee osteoarthritis (OA) occurs via MAPK ERK, JNK, and p38 signaling pathways and the PI3K signaling pathway in cultured cells debrided from OA knees., uPA and uPAR are involved in generation of drug-resistant small-cell lung cancer cell phenotype., The association between tissue factor and uPA/suPAR system is significantly related to the presence of cardiovascular disease in hemodialysis patients, PLAUR and the somatomedin B region of VTN direct the localization of UPA to focal adhesions in microvessel endothelial cells., Both uPA and PAI-1 are up-regulated in epithelial ovarian cancer., The PLAU gene codes for this enzyme, and is located on 10q24. This region has demonstrated evidence for linkage in a genome scan for asthma in a sample from northeastern Quebec., In thyroid cells, plasminogen activators are regulated via MAPK and protein kinase c-beta pathways., Altered expression of PLAU was observed in high-risk soft tssue sarcomas., pemphigus vulagris-IgG-dependent uPA activation is not related to anti-Dsg3 antibody activity, stromal fibroblasts play a role in promoting pancreatic cancer metastasis via activation of the uPA-plasminogen-MMP-2 cascade, suggest a novel function for tyrosine kinase 2 as an important modulator of the urokinase-directed vascular smooth muscle cell functional behaviour at the place of injury, Simultaneous down-regulation of uPAR and uPA induced caspase-8 mediated apoptosis., The urokinase plasminogen activator (BamHI) and plasminogen activator inhibitor type 1 (HindIII) genotypes may serve as useful markers for heritability of bone loss associated with periodontal disease., STI571 influence through inducing urokinase-type plasminogen activator and interleukin-8, in which the induction of early growth response-1 expression and extracellular signal-regulated kinase 1/2 phosphorylation might be involved., the p38(MAPK) signaling pathway is required for optimal LPA-dependent uPA secretion from ovarian cancer cells, There was a significant positive linear association between ERK1/2 activity and uPA protein expression in laryngeal squamous cell carcinoma., silencing of uPA significantly inhibits prostate tumor growth and the incidence of lung metastasis, we demonstrated that tyrosine phosphorylation of EGFR and the autocrine expression of uPA and HB-EGF depend on the activity of c-jun amino-terminal kinase (JNK) in human prostatic DU-145 cells., simultaneous downregulation of uPAR and matrix metalloprotease-9 using RNAi technology may provide an effective tool for breast cancer therapy, Urokinase plasminogen activator (uPA) stimulates cholesterol biosynthesis in macrophages through activation of SREBP-1 in a PI3-kinase and MEK-dependent manner, uPA plays a major role in inducing MMP-1 production in activated human monocytes, which is mediated by a plasmin-dependent mechanism involving signaling through the annexin A2 heterotetramer., review of uPA - uPAR interactions with membrane proteins to modify signal transduction pathways and their role in oral squamous cell carcinoma, data of study population indicate a higher ETS2 RNA concentration compared with uPA in the case of bladder cancer, resulting in an increased ETS2, HDAC1 knockdown by small interference RNA stimulated uPA expression and cancer cell invasion., Elevated expression of MMP-1 and urokinase plasminogen activator can be used to identify patients with a worse prognosis in skull base chordoma., In xenograft glioblastoma mouse model and in vitro invasion assay, LRP-deficient cells, which secreted high levels of uPA, invaded the surrounding normal brain tissue, whereas the LRP-overexpressing and uPA-deficient cells did not invade normal brain., The urokinse haplotype CGCCCC is a genetic risk fctor for higher mortality and more severe clinical outcome with infection-associated acute lung injury., The carotid atherosclerosis is independently related to uPA/its soluble receptor system in dialysis patients, Myeloma-osteoclast interactions stimulated the production of TRAP, cathepsin K, MMP-1, -9, and uPA, The multimarker phenotype of the absence of CD8+ TILs, loss of p27, and positive uPA expression was predictive of an adverse prognosis in patients with lymph node-negative, MMR-proficient colorectal cancer., protein kinase C synergistically enhances the secretion of uPA in TNF-alpha-stimulated human dental pulp cells, In human renal tissues, protein C inhibitor and urinary plasminogen activator colocalized in the cytoplasm of renal proximal tubular epithelial cells, Data show that fibroblastic inflammatory reaction around the biopsy channel affects stromal uPA and PAI-1 expression, which possibly leads to falsely increased enzyme levels in ELISA., IL-1beta stimulates uPA production via activation of NFkappaB and tyrosine phosphorylation, and also secretion of the enzyme, and that the uPA/plasmin system appears to be involved in inflammation in human dental pulp., Each additional copy of the minor allele PLAU-3995 (Pro41Leu,(rs2227564) was associated with higher log(D-dimer) levels., Together, the data indicate that SAA enhances plasminogen activation and suggest its possible role in plasmin(ogen)-mediated colon cancer progression., Inactivation of FOXO3a after GR activation is an important mechanism contributing to GC-mediated repression of uPA gene expression in breast epithelial and cancer cells., Urokinase 3"-UTR T/C gene polymorphism seems to appear more commonly in children with recurrenct calcium oxalate stone disease than in healthy children and in those with stones for the first time., The plasma uPAR and uPA levels in nosebleed patients before treatment is higher than that in normal group., TSP-1 promotes human follicular thyroid carcinoma cell invasion mainly through up-regulation of the urokinase-dependent activity, SAK reduces tPA/uPA-mediated Plg activation by means of SAK.Plg complex formation, consequently downregulating tPA/uPA-induced fibrinolysis., upon cell binding and internalization, single-chain uPA (scuPA) translocates to the nucleus within minutes. Nuclear translocation does not involve proteolytic activation or degradation of scuPA., uPA-mediated direct activation of MMP-9 may promote glioblastoma cell invasion., A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor., UPA expression was significantly up-regulated in pancreatic ductal adenocarcinoma., reports the crystal structures of uPAR in complex with both urokinase (uPA) and vitronectin and reveal that uPA occupies the central cavity of the receptor, whereas vitronectin binds at the outer side of the receptor, observations confirm a new role for p53 as a uPA mRNA binding protein that down-regulates uPA mRNA stability and decreases cellular uPA expression, Urokinase plasminogen activator upregulates paraoxonase 2 expression in macrophages via an NADPH oxidase-dependent mechanism., the uPA system may be involved in the progression of prostate cancer, The expressions of both uPA mRNAs in the gastric cancer cells increased obviously (12-fold and 3-fold, respectively) with H. pylori stimulation., NF-kappaB-mediated up-regulation of uPA expression is responsible for EGF-induced invasiveness in pancreatic cancer cells., The pathogenesis of idiopathic pulmonary fibrosis is complex & the urokinase-type plasminogen activator (uPA)/plasminogen system participates in the repair process. Review., The results of this study support previous observations linking PAI-1 with airway remodeling and uPA with cellular inflammation. Moreover, the observed effect of uPA seems to be independent of its fibrynolytic activity., uPA expression in metaplastic, dysplastic, and esophageal cancer tissue is associated with neoplastic progression of esophageal lesions, Report increased expression of uPA by Helicobacter pylori in gastric epithelial cells., Evaluation of urokinase plasminogen activator in urine from individuals with Quebec platelet disorder., the plasma levels of uPA and uPAR are closely related to the degree and period of inflammation in patients with acute or chronic hepatitis B, and that uPA and uPAR might be important indicators for disease progression, Determination of serum CATB and plasma UPA levels may be useful to identify patients at a higher risk for progression to cancer., uPA and uPAR in the synovial fluid may play a role in the pathogenesis of temporomandibular disorders., uPA-binding loops of ECRG2 are in correspondence with the reactive site loops for binding of serine proteinase in turkey ovomucoid third domain (OMTKY3)., uPAR and beta1-integrin interactions are essential to signals induced by integrin matrix ligands or uPA in lung cancer cells., uPA/uPAR downregulation inhibits radiation-induced migration, invasion and angiogenesis in IOMM-Lee meningioma cells and decreases tumor growth in vivo., suPAR, prevents the interaction of urokinase with membrane-anchored uPAR on residual normal cells., mutation in an uncharacterized cis element near PLAU is the cause of Quebec platelet disorder, uPA not only generates active PDGF-DD, but also regulates its spatial distribution, provides novel insights into the biological function of PDGF-DD., Carcinoembryogenic antigen-related cell adhesion molecule (CEACAM)-1 and the urokinase plasminogen activator (uPA)/uPA-receptor (uPAR) pathway were identified as possible mediators in HGF-induced keratinocyte migration., overexpression of uPA in Quebec platelet disorder emerges with megakaryocyte differentiation, without altering the expression of flanking genes, Data show the effects of nitric oxide and hydrogen peroxide on the expression of tissue-type plasminogen activator (t-PA), urokinase-PA, u-PA receptor, and plasminogen activator inhibitor type 1 (PAI-1) in human umbilical vein endothelial cells., These results demonstrated that in A549 cells, activation of p50/p65 heterodimer through sequential activation of PKC alpha-JNK-NIK-IKK beta-NF-kappaB was required for IL-1 beta-induced uPA expression associated with migration of tumor cells., uPA and haptoglobin are produced by the cancer cells and are not taken up by stromal elements., uPA exon 6 C/T polymorphism is associated with invasive phenotype of gastric cancer, but not with susceptibility or survival of gastric cancer. uPA intron 7 is a silent polymorphism., The higher expression of uPAR/uPA in most of the opportunistic cerebral lesions supports their role in these diseases, suggesting their contribution to tissue injury., analysis of urokinase, urokinase receptor and plasminogen activator inhibitor-1 in colon cancer liver metastases, Report recombinant production of a hybrid plasminogen activator composed of surfactant protein B and low-molecular-weight urokinase., Results demonstrate that SHP-2 plays an important role in uPA-directed signaling and functional control of human VSMC and suggest that this phosphatase might contribute to the pathogenesis of the uPA-related vascular remodeling., the involvement of Notch1 in human PCa invasion and that silencing of Notch1 inhibits invasion of human PCa cells by inhibiting the expression of MMP9 and uPA, The positive expression of uPA and uPAR in hypopharyngeal carcinoma were significantly higher than in normal tissue., Urokinase & its receptor UPAR exert a regulatory effect on physiologic cell migration as well as tumor growth and metastasis. Review., The uPA up-regulation increased LASP-1 expression and that both were implicated in SKHep1C3 motility. siRNA LASP-1 inhibition showed that LASP-1 was involved in actin microfilaments organization of SKHep1C3 cells., an increased activation of the uPA system possibly contributs to the inflammatory phenotype seen in subgroups of common variable immunodeficiency patients., results suggest that uterine natural killer cells may regulate extravillous trophoblast invasion and spiral artery remodeling via the uPA system., survivin is an essential mediator of arthritogenic properties of uPA regulating its synthesis in synovial fibroblasts and uPAR expression in leucocytes, Cell migration in response to the amino-terminal fragment of urokinase requires epidermal growth factor receptor activation through an ADAM9/10-mediated mechanism., the 20-26 amino acid residues of uPA are important for the binding between uPA and uPAR, and that the electrostatic interactions between the charged amino acid residues existing in both uPA and uPAR have large contribution to the binding, LPS promotes tumour cell ECM adhesion and invasion through activation of the u-PA system in a TLR-4- and NF-kappaB-dependent manner., Tumor stroma is the predominant UPA- expressing tissue in human breast cancer, Results show that overexpression of miR-23b leads to uPA and c-met downregulation and to decreased migration and proliferation abilities of HCC cells., Urokinase activates macrophage PON2 gene transcription via the PI3K/ROS/MEK/SREBP-2 signalling cascade mediated by the PDGFR-beta., The expression of nm23 protein positively correlated with tPA level (r(s)=0.4; p=0.01) and did not correlate with the content of uPA and PAI-1 in tumors. Data confirm the role of the studied proteins in invasion and metastases of malignant tumors, mRNA expression for uPA was significantly lower in liver metastases compared with primary breast tumours and lymph node metastases., EMT was reversed by silencing expression of endogenously produced urokinase-type plasminogen activator (uPA), which is necessary for uPAR-dependent cell signaling., Soluble urokinase receptor conjugated to carrier red blood cells binds latent pro-urokinase and alters its functional profile., 3,3'-Diindolylmethane (B-DIM) down-regulates uPA-uPAR in aggressive breast cancers but in the absence of uPA-uPAR, B-DIM can directly inhibit VEGF and MMP-9 leading to the inhibition of cell growth and migration of breast cancer cells, miR-193b is closely associated with clinical metastasis and identifies miR-193b potentially targets uPA transcripts., Monocyte urokinase-type plasminogen activator up-regulation reduces thrombus size in a model of venous thrombosis., Data show that ehe expression level of uPA and MMP-2 was not associated with the grade of CIN lesions., The uPA-plasmin system participates in prostate carcinoma-high disseminating intravasation, possibly via promoting tumor cell matrix invasion and facilitating development of VEGF-dependent angiogenic blood vessels., Upon urokinase plasminogen activator stimulation, UPAR, Matrix metalloproteinases, integrin alphavbeta3 and NSMASE2 form a signaling complex that take part in mitogenic signaling in ECV304 cells., uPA, but not uPAR, is an independent prognostic factor and that this negative effect on survival is relevant specifically for mismatch repair-proficient colorectal cancers., Preoperative mucosal uPA and plasma PAI-1 protein expression could possibly be used as prognostic factors in rectal cancer, Results suggest that uPA could be considered for further studies as a possible useful therapeutic target in breast cancer., These novel findings suggest a model in which CK8, together with uPA, plasminogen and fibronectin, constitutes a signaling platform capable of modulating cell adhesion/growth-dependent signal transduction in breast tumor cells., de-N-acetyl GM3 stimulates migration and invasion of melanoma cell lines by increasing the expression and activation of urokinase-like plasminogen activator, Tandem duplication of the urokinase plasminogen activator gene is associated with Quebec platelet disorder., HGF is activated by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA., Intramuscular electroporation of TIMP-1 linked to the amino terminal fragment of urokinase inhibits vein graft thickening in vein grafts in carotid arteries of hypercholesterolemic mice., Patients with high uPA and/or PAI-1 levels in the primary tumor may benefit more from the adjuvant anthracycline-containing regimens than from CMF-based chemotherapy, overexpression of ErbB2 promotes invasive and migratory abilities of H-Ras-activated MCF10A human breast epithelial cells through upregulation of matrix metalloproteinase (MMP)-13 and urokinase-type plasminogen activator (uPA)., As expression of members of the uPA system in tumour tissue and serum is additively correlated with prognosis of soft tissue sarcoma patients., predominantly associated with poised (S5p+S2p-) factories prior to activation and localized at the chromosome territory interior, Both tissue-type PA (tPA) and urokinase-type PA (uPA) bind to NMDA-R1 and reverse this effect, thereby enhancing acetylcholine-induced tracheal contractility., A combination approach using uPA and uPAR siRNA therapy along with radiation treatment produced target-specific effects with regard to inducing apoptosis in meningioma., Statistically significant correlation between mRNA and protein expression of uPA in breast cancer., Activation of human pro-urokinase by unrelated proteases secreted by Pseudomonas aeruginosa, Increased plasma levels of uPA and TGF-beta1 are associated with the occurrence and development of preeclampsia., Demonstrate increased expression of uPA and uPAR in human seminomas with respect to normal testis tissues, which may be relevant in testicular cancer progression., The activation by u-PA was enhanced by 2.86 microg/ml of S-2, 4-6-fold by of 32.4 mmol/l of lysine or 5.4 mmol/l of 6-aminohexanoic acid and 14-16-fold enhancement by addition of both S-2 and lysine or S-2 and 6-AH showing a synergistic effect., The cerebrospinal fluid uPA and MMP-9 levels of the eosinophilic meningitis associated with angiostrongyliasis patients were significantly higher than those of the controls (p<0.001)., investigation of regulation of gene expression of uPA, MPO, urokinase, XPA and XPD polymorphisms are not related to leiomyoma susceptibilities., airway smooth muscle activation of plasminogen by uPA is accelerated in a collagen-rich environment in which the inhibitory effect of TGF-beta is attenuated in association with greater uPA expression induced via beta1-integrin signaling, In Buerger's disease, PAI-1 was strongly expressed around the internal elastic lamina, while both uPA and MMP-3 were slightly recognized on vessel walls., uPA levels were increased in high grade tumours, whereas plasminogen activator inhibitor 1 was elevated in cases with venous invasion, uPA/uPAR downregulation suppresses angiogenesis in endothelial cells induced by glioblastoma cell lines, The increase of PAI-1 and uPA can contribute to the enhancement of metastasis and invasive potential of tumour cells., role of single nucleotide polymorphism of uPA and uPAR in non-small cell lung cancer, Curcumin facilitates fibrinolysis and cellular migration during wound healing by modulating urokinase plasminogen activator expression., Data show that GATA6 is an important regulator of uPA gene expression, and the dysregulated expression of GATA6 contributes to colorectal tumorigenesis and tumor invasion., OPN enhanced hepatocellular carcinoma cells invasion through interaction with its receptor CD44v6 and increased MMP-2 and uPA expressions., The study demonstrated that in papillary thyroid cancer the increased gene expression of uPA and cognate receptor is associated with tumor invasiveness, Specific suppression of osteopontin also inhibited matrix metalloproteinase 2 (MMP-2) and urokinase-type plasminogen activator (uPA) expression in HCCLM6 cells., Anti-tumor efficacy of down-regulation of uPA or uPAR in medulloblastoma tumors to target hypoxia-induced cell EMT, invasion and migration, to achieve better therapeutic outcomes in the treatment of malignant medulloblastoma., we report a strategy to generate a PAI-1.uPA(S195A) Michaelis complex and present its crystal structure at 2.3-A resolution, High expression of uPA and ET-1 were found in lung adenocarcinomas., Data show that p15/miR-23b/uPA are involved in HPV-16 E6-associated cervical cancer development., PAI-2 is capable of inhibiting uPA in the presence of PAI-1, particularly on adherent cells in the presence of vitronectin, The targeting uPA not only inhibited established intracranial tumors but also radiation-induced recruitment of endothelial cells and monocytes towards the tumor region., The effect of SDF-1 on colorectal cancer cell signaling and uPA expression is mediated by the CXCR4/beta1 integrin axis., Results show that silibinin decreased MMP-2, MMP-9, u-PA, p-p38, and p-Erk1/2 expressions in a concentration-dependent manner., A C to T polymorphism of urokinase plasminogen activator (P141L) is associated with Helicobacter pylori infection., Active uPA was found to be flexible with a random conformation of the amino-terminal fragment domain with respect to the serine protease domain., miR-193a affects invasive growth through PLAU. A pathway in which Max & RXRalpha inhibit miR-193a activates the PLAU & K-Ras oncogenes is important for distinct aspects of cellular transformation., Macrophage-derived uPA transgene promotes muscle regeneration by inducing macrophage migration, angiogenesis, and myogenesis., increased expression in sinonasal mucosa of chronic rhinosinusitis patients with polyps, High Urokinase expression is associated with poor treatment response in colorectal carcinoma., No association between uPA (rs4065)polymorphism and endometrial carcinoma risk, TGF-beta1-induced activation of Smad3 is the critical step for the uPA upregulation and E-cadherin downregulation, In the Brazilian population, genetic variations in both uPA and TAFI were not relevant to endometriosis and/or infertility., These results indicate that urokinase plasminogen activator, plasminogen activator urokinase receptor and maspin expression patterns may be useful markers for evaluating the clinical course or prognosis of oral squamous cell carcinoma patients, Data show that kahweol inhibits HUVEC MMP-2 and urokinase involved in angiogenesis., MMP-9 and uPA might be involved in the activation of pro-MMP-13 through unknown mechanisms in arthritic diseases., A possible interaction between IL-6, OSM, u-PA and VEGF in prostate cancer was investigated., Confirmed the correlation between elevated uPA values & an aggressive course of invasive breast cancer., down regulation of uriokinase plasminogen activator (uPA) or uPA receptor results in the inhibition of glioma cell invasion via inhibition of Notch 1 receptor cleavage, signaling and endosomal trafficking of the Notch 1 receptor, Studies indicate that the genetic cause of QPD is a tandem duplication mutation of the uPA gene, PLAU, which upregulates uPA expression in megakaryocytes by an unknown mechanism., Posttranscriptional regulation of uPA involves the newly recognized pathway of approximately 40 kDa cytoplasmic-nuclear shuttling protein ribonuclease reductase M2 (RRM2) present in the uPA mRNA 3'untranslated region (UTR)., Small hairpin RNA against uPA and/or uPAR increased secretion of TIMP-1, which is known to enhance SVEGFR1 secretion in endothelial cells and glioblastoma cells., Resveratrol reduces TNF-alpha-induced U373MG human glioma cell invasion through regulating NF-kappaB activation and uPA/uPAR expression, suggest that uPA promotes cell migration by binding to fibulin-5, initiating its cleavage by plasmin, which leads to its dissociation from beta1-integrin and thereby unblocks the capacity of integrin to facilitate cell motility, HDAC inhibitor trichostatin A (TSA) increased the expression of TIMP-1 and TIMP-3 while decreased MMP-2, MMP-9 and uPA and have an inhibitory effect on trophoblast invasion., Data show that urokinase plasminogen activator expression correlates with lymphatic invasion and metastasis in vivo and is required for CCA cell invasion in vitro, suggesting its potential as a therapeutic target., Individuals with uPA/PAI-1 CC/4G5G allele were in high susceptibility for cervical neoplasia. The combined polymorphism of uPA/PAI-1 might diminish the ability of PAI-1 to inhibiting cervical cancer carcinogenesis when PAI-1 alone as the role of inhibitor, uPA, uPAR, and PAI-1 were quantified by enzyme-linked immunosorbent assay (ELISA) in extracts of 226 breast tumor biopsies., The downregulation of uPA/uPAR results in increased integrin alphavbeta5 cell-surface protein levels that regulate the activity of beta1 integrins, promoting characteristics of the persistent Myofibroblasts., aminoterminal fragment requires NAD(P)H oxidase activity through a Gbetagamma-, rac-, and src-mediated pathway to facilitate transactivation of EGFR and vascular smooth muscle cell migration, SphK1 promoting the secretion of MMP-2/9 and uPA via activation of ERK1/2 and suppression of p38 MAPK pathways maybe the molecular mechanisms for its regulation of the malignant behavior of colon cancer cell., In papillary thyroid carcinoma BRAFV600E is associated with increased expression of the urokinase plasminogen activator and its cognate receptor, but not with disease-free interval., Data suggest that lycopene, a dietary component, inhibits angiogenesis; lycopene appears to down-regulate signal transduction by inhibition of uPA and MMP2 (matrix metallopeptidase 2) via vascular endothelial growth factor receptor 2 signaling., urokinase plasminogen activator is involved in mediating the tumor-suppressing effects of CFTR, these data suggest that PKD2 and PKD3 coordinate to promote prostate cancer cell invasion through p65 NF-kappaB- and HDAC1-mediated expression and activation of urokinase-type plasminogen activator (uPA)., The detrimental effects of atherogenic LDL on VSMC are mediated by a decrease and delocalization of the UPA-UPAR interaction that result in an impairment of cytoskeleton dynamics and adhesion capacity affecting cell phenotype and function., novel functions of gelsolin in colorectal tumor cell invasion through its modulation of the uPA/uPAR cascade, Data indicate that knockdown of interleukin enhancer-binding factor 3 (ILF3) leads to the increased levels of mature urokinase-type plasminogen activator (uPA) mRNA-targeting miRNAs miR-193a, miR-193b and miR-181a., UPA and VEGF protein expression of the high microvessel density (MVD) group was significantly lower than in the low MVD group (P < 0.05)., study investigated the role of uPA, PAI-1, MMP-2, and TIMP-2 in formation of self-assembled network in the 2D co-ulture of bone marrow stromal cells and HUVECs; data showed that uPA played an important role in network formation, while the process appears independent on TIMP-2 but involved MMP-2, Complexes between alpha2-macroglobulin and urokinase were detected in alveolar edema fluids as well as in lungs of patients with acute lung injury/acute respiratory distress syndrome where they were located mainly in close proximity to epithelial cells., PLAU is particularly important for memory Tregs and PLAU mediates Treg suppressor function via STAT5 and ERK signaling pathways., UVA stimulated the production of uPA, a key factor in the modulation of extracellular matrixes, inflammatory processes, and angiogenesis., the effect of the mu-opioid receptor selective peptide, morphiceptin, and its two synthetic analogs on mRNA and protein levels of MMP-9, Dose-dependent increases in uPA and IL-8 expression were detected following TRAIL stimulation in pancreatic ductal adenocarcinoma cells., In conclusion, our data suggest that radiation-mediated hypomethylation triggers uPA expression in meningioma cells., P141L and 3'-UTR polymorphisms of the urokinase gene are not associated with urolithiasis in a Japanese population, Urokinase plasminogen activator induces pro-fibrotic/m2 phenotype in murine cardiac macrophages., These data support the hypothesis that uPA upregulation stimulated by macrophages may play an active role in the onset of osteoarthritis and in the shear-stress protection against this induction., Results show that stromal cell-derived factor-1 (SDF-1) enhanced ovarian cancer cell invasion through alphavbeta6 integrin-mediated urokinase-type plasminogen activator (uPA) expression via the p38 MAPK and PI3 K/Akt pathway., The findings provide evidence that the rs2227564 C/T SNP in the u-PA gene is associated with the development of oral tongue squamous cell carcinoma., uPA has a major role in cholesterol biosynthesis; PLAU Pro141Leu (rs2227564) is significantly associated with serum lipid levels in a Japanese population, Analysis revealed a positive correlation between u-PA and MMPs and a negative correlation between u-PA/MMPs and TIMPs. These findings suggest the therapeutic potential of NM in treatment of adult sarcomas, The effects of UPA/UPAR on migration of lipid-loaded cells occurred through the binding to LRP-1., T allele of rs2227564 polymorphism in PLAU gene could increase the effects on risk of Alzheimer's disease, The beta sheet in the growth factor-like domain is not necessary for high affinity binding of uPA to uPAR., Results show that uPA regulates Lhx2 expression by suppressing expression of miR-124 and p53 expression. These results demonstrate that regulation of gene transcription by uPA contributes to pancreatic cancer cell stemness and clinical lethality, We found no association between allele frequency and risk of multiples sclerosis for any single nucleotide polymorphism investigated for PLAU, The expression of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) was up-regulated in co-cultures with squamous cell carcinoma cells but not with normal oral keratinocytes., Analysis revealed a positive correlation between u-PA and MMPs and a negative correlation between u-PA/MMPs and TIMPs., The uPA expression was significantly correlated with TMPRSS4 expression in human lung and prostate cancers., The expression of the uPA system positively correlates with peritoneal metastasis of gastric cancer., SERPINE2 and PLAU are involved in cumulus expansion and oocyte maturation., High preprocedural plasma uPA and serum CRP levels are indicative of angina recurrence after successful PTCA, and are valuable for the prognosis of restenosis., Plasminogen stimulates airway smooth muscle cell proliferation in a manner mediated by urokinase and annexin A2., The uPA/uPAR angiogenesis regulatory system supports the endothelial cells that need to migrate, invade the extracellular matrix, survive, proliferate, and to re-establish new contacts with cells and the surrounding matrix. (Review), uPAR, IL-33, and ST2 values as a predictor of subclinical chorioamnionitis in preterm premature rupture of membranes., Oncogenic K-Ras and loss of Smad4 mediate invasion by activating an EGFR/NF-kappaB Axis that induces expression of MMP9 and uPA in human pancreas progenitor cells., TMPRSS4 directly converted inactive pro-uPA into the active form through its proteolytic activity. Conditioned medium from cells overexpressing TMPRSS4 showed that the active TMPRSS4 protease domain is released and is associated with the plasma membrane., Matrix metalloproteinases (MMP)--MMP-1,-2,-9 and its endogenous activity regulators in transformed by E7 oncogene HPV16 and HPV18 cervical carcinoma cell lines, Decreasing uPA levels sensitized cancer cells to TRAIL, leading to markedly increased apoptosis., results of this study suggest that uPA decreases the removal of HDL-cholesteryl ester in the liver via suppression of the hepatic scavenger receptor class B type I (SR-BI)expression, High u-PA expression is associated with metastasis in breast cancer., Urokinase plasminogen activator is a central regulator of macrophage three-dimensional invasion, matrix degradation, and adhesion., IL-1beta-induced urokinase plasminogen activator expression via activation of the ERK1/2 and NF-kappaB pathways, which results in invasion of gastric cancer cells., Suggest a possible protective effect of podocyte uPA/uPAR expression against interstitial fibrosis in IgA nephritis., IL-33 is involved in u-PA-driven angiogenesis, a process that has been shown before to be linked to inflammation in various pathologies., These effects were mediated by the efficient conversion of pro-uPA to active uPA and high phosphorylation levels of ERK detected in the PANC-1 cells expressing exogenous polyserase-1., we are reporting the strong correlation among uPA and ECM proteins in newly diagnosed MM patients of different stages., Studied the relationship between uPA gene polymorphisms and clinical manifestations of idiopathic membranous nephropathy., The mRNA expression levels of uPA, its receptor (uPAR), and its inhibitor type 1 (PAI-1) were analyzed in corresponding malignant and adjacent nonmalignant tissue specimens from 132 PCa patients by quantitative PCR., SNP P141L associated with collateral circulation in coronary artery disease, In human coronary vascular smooth muscle, uPA induces uPAR-independent, domain-dependent smooth muscle cell proliferation through transactivation of EGFR by a plasmin-mediated, ADAM-induced, and HB-EGF-dependent process., miR-193b inhibits the expression of stathmin 1 (STMN1) and urokinase-type plasminogen activator (uPA) in Panc-1 cells., uPA/uPAR stimulates triglyceride synthesis in Huh7 hepatoma cells via p38-dependent upregulation of DGAT2, Data show that the plasminogen activator urokinase (uPA)/plasminogen activator inhibitor 1 (PAI-1) ratios in prostate cancer (PCa) patients to be significantly higher than in benign prostatic hyperplasia (BPH) patients., Data indicate that mucin 1 (MUC1) forms a complex with NF-kappaB p65 transcription factor and binds to urokinase-type plasminogen activator (uPA) promoter, and thereby induces uPA expression., Taking uPA(1-43) amino acids specifically binding to uPAR as targeted part of fusion protein, and making use of antitumor activity of melittin, the recombinant fusion protein it was able to inhibit growth of ovarian tumors ., IL-17 may act as chemotropic factor for peripheral blood-Mesenchymal stem cellss by incrementing cell motility and uPA expression during inflammation development., Silencing of ETV4 suppresses invasion of prostate cancer cells by inhibiting the expression of uPA/uPAR as well as (MMP)-2 and MMP-9, we found that in HS fibroblasts (HFs) miR-181c and miR-10a were differentially-expressed and targeted uPA and PAI-1, respectively. The production of Type 1 collagen (Col1) was inhibited by miR-181c knockdown or miR-10a overexpression, Data indicate that urokinase-type plasminogen activator (uPA) activates epithelial sodium channel, gamma subunit (ENaC gamma) through catalytic activity-dependent proteolytic modification., Data suggest that enhanced levels of uPA in breast cancer modulate the mitogenic effects of EGF which helps to better understand breast cancer pathogenesis., Studied urokinase-type plasminogen activator regulation in cigarette smoke extract (CSE)-induced EMT in human small airway epithelial cell lines (HSAEpiCs)and in the small airway epithelium of COPD patients., Crystal structure of uPA bound with cyclic peptidic inhibitors., DIM can influence the cell migratory and invasive properties of human colorectal cancer cells and may decrease the invasive capacity of colorectal cancer through downregulation of uPA and MMP9 mediated by suppression of the transcription factor FOXM1, Porphyromonas gingivalis-derived RgpA-Kgp complex activates the macrophage uPA., Activation of uPA and MMP-3 in perifocal zone of the tumor can serve as an indexof its invasive activity., The predominance of uPA over PAI-1 in the gastric mucosa vessels and epithelial cells can play a role in the development of gastric mucosa bleeding., u-PA is a dysregulated gene involved in the tumorigenesis, bio-pathological features and outcomes of EEC., data on the stromal macrophages immunoreactivity of uPAR, MMP-2, and MMP-9 in a few small cell lung cancer (SCLC) and lung squamous cell carcinoma (SCC) biopsies was included. uPAR, MMP-2, and MMP-9 were confirmed in stromal cells including macrophages, it was found that the recombinant fusion protein uPA17-34-KPI(kunitz-type protease inhibitor ) inhibited the invasion and metastasis of ovarian tumors, Results found high levels of uPA and uPAR exclusively in metastatic osteosarcoma (OS)cells and suggest that malignant conversion of OS cells to uPA/uPAR axis in an autocrine and paracrine fashion., High cytoplasmic expression of uPA is associated with cells of rectal cancer and metastases of perienteric lymph nodes., The morphologically normal tissue adjacent to the tumor shows the substantial expression of MMP-2 and MMP-9 and in some cases the enhanced activity of uPA and ACE, which makes an additional contribution to the increased invasive potential of tumor,
OMIM_DISEASE Alzheimer disease, late-onset, susceptibility to, Quebec platelet disorder,
SP_COMMENT catalytic activity:Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin., function:Specifically cleave the zymogen plasminogen to form the active enzyme plasmin., online information:Urokinase entry, pharmaceutical:Available under the name Abbokinase (Abbott). Used in Pulmonary Embolism (PE) to initiates fibrinolysis. Clinically used for therapy of thrombolytic disorders., PTM:Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding., similarity:Belongs to the peptidase S1 family., similarity:Contains 1 EGF-like domain., similarity:Contains 1 kringle domain., similarity:Contains 1 peptidase S1 domain., subunit:Found in high and low molecular mass forms. Each consists of two chains, A and B. The high molecular mass form contains a long chain A which is cleaved to yield a short chain A. Binds LRP1B; binding is followed by internalization and degradation. Interacts with MRC2. Interacts with PLAUR., tissue specificity:Expressed in the prostate gland and prostate cancers.,