Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma(PIK3CG) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma(PIK3CG) Related Genes Homo sapiens
CYTOBAND 7q22.3,
GENERIF_SUMMARY PI3K promotes assembly of adherens junctions, which, in turn, control p38 MAPK activation and enterocyte differentiation., activates phosphatidylinositol 3 (PI3) kinase and requires PI3 kinase to regulate the cell cycle [TEL/platelet-derived growth factor receptor beta], PI3K inhibits HIV-1 transcription by targeting the viral protein Tat activation complex., data indicated that the v-Crk-induced activation of PI3K/AKT pathway was cooperatively achieved by two distinct interactions, CB(1)-induced ERK activation was mediated by PI3K(IB) and this effect may have important consequences in the control of cell death/survival decision., Bordetella pertussis infection of human monocytes resulted in a marked recruitment of cellular PI3-K to the sites of B. pertussis contact, Down-regulation of PIK3CG by CpG hypermethylation is associated with progression of colorectal cancer, higher protein levels of the PI3K subunit p110 in neutrophils from MDS patients, These results indicate that PI3k/Akt pathway is involved in the signaling cascade of glioma cells required to induce cell migration., regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages, PI3-K activation is signaled by rapid feedback amplification that involves P2Y(12) receptor-mediated activation of Syk., migrating glioma cells activate the PI3-K survival pathway, protecting migrating cells from apoptosis, 1) the PI3K-Akt pathway plays an important role in preventing Fas-mediated apoptosis; and 2) a PI3 K inhibitor, such as LY294002, might be a useful anti-tumoral agent for gastric carcinoma, Vanadyl sulfate treatment also prolonged the insulin-stimulated activation of phosphatidylinositol 3-kinase (PI3-K)., Activation of hexosamine pathway affects glucose-induced phosphorylation of IRS-1. Impairs coupling of IRS-1 and PI 3-kinase and activativates Akt/mammalian target of rapamycin/phosphorylated heat- and acid-stable protein-1/p70S6 kinase pathway., Thus, our results identified a functional region in the IL-1R AcP required for the recruitment and activation of PI 3-kinase., PI3Kgamma appears to negatively control cardiac contractility through different signalling mechanisms [review], In Goto-Kakizaki rat soleus muscle, chronic administration of antioxidant alpha -lipoic-acid partly ameliorated the diabetes-related deficit in glucose metabolism including the enzymes Akt/PKB and PI-3 kinase., stromal cell-mediated apoptotic protection in B-lineage ALL is mediated by PI3K/mTOR and MEK via a synergistic mechanism, PI 3-kinase-initiated signaling pathway is one of the most frequently altered in head and neck squamous cell carcinoma., Amiloride enhances TRAIL-induced cytotoxicity by inhibiting phosphorylation of the PI 3-Kinase-Akt pathway-associated kinases and phosphatases., there is a previously unknown, p101-related regulatory subunit for PI3Kgamma, activation of the PI3K/Akt pathway identified as an anti-inflammatory signal that may contribute to the establishment of Salmonella typhimurium in the intestine., IL-4 > PI3K/Akt > NF-(kappa)B signaling pathways, which activate androgen receptor signaling, play an important role during the development of androgen independent prostate cancer cells., PI3-K promotes the expression of TFF3 and MUC2 and that the PI3-K pathway may play a pivotal role in intestinal goblet cell differentiation., p110gamma and p85alpha class Ia phosphoinositide 3-kinase (PI3K) subunits play roles in generating the antiapoptotic and chemoresistant phenotype associated with accelerated local tumor recurrence, Acanthamoeba castellani-mediated brain microvascular endothelial cell death is dependent on phosphatidylinositol 3-kinase, Stimulation of TNF-alpha-primed human neutrophils with fMLP results in biphasic activation of PI3K; the first phase is largely dependent on PI3Kgamma; the second phase is largely dependent on PI3Kdelta and regulates parallel activation of ROS production, the PI3-kinase/p38(MAPK)/CREB pathway contributes to the EGF activation of NF-IL6beta gene expression, the nSH2 domain of the p85 regulatory subumit is responsible for p110 regulatory contacts, and its disruption leads to constitutive p110 activity, In conclusion, erythropoietin may attenuate high glucose-induced endothelial cell apoptosis via PI-3 kinase pathway., The protein phosphorylation activity of PIK3 plays an essential role in beta-adrenergic receptor internalization and identify non-muscle tropomyosin as a cellular substrate., In human islets, activation of PPAR-gamma inhibits h-IAPP-induced islet cell apoptosis, and this action is at least in part mediated through activation of the phosphatidylinositol 3'-kinase-Akt cascade., The TGFbeta(1)-induced destabilisation of E-cadherin-mediated cell-cell adhesion involves phosphorylation of beta-catenin, which is regulated by E-cadherin adhesion complex-associated PI3-kinase and PTEN., as tumorigenesis progresses the addiction of cancers to their initiating oncogene is reduced to, at least in the case of Ras, the PI3K/AKT pathway., this specific PI 3-kinase isoform is involved in both proliferation and the apoptosis resistance associated with chronic myeloid leukemia, These results suggest that the cytoprotective effect of deprenyl is, in part, dependent on Nrf2-mediated induction of antioxidative proteins, suggesting that activation of the PI3K-Nrf2 system may be a useful therapeutic strategy for PD., Results showed that inhibition of PI-3 kinase with wortmannin was accompanied by a considerably reduced expression of beta-catenin., analysis of a nuclear matrix attachment region like sequence in the last intron of PI3Kgamma, p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase have roles in oncogenic transformation, Cellular responsiveness to Notch signals depends on the activity of the PI3K-Akt pathway in cells as diverse as CHO cells, primary T-cells and hippocampal neurons., It is concluded that PI3-kinase induces or modulates the activity of recombinant TRPV2 channels; in contrast to the previously proposed mechanism, activation of TRPV2 channels by PI3-kinase is not due to channel translocation to the plasma membrane., The phosphatidylinositol 3-kinase (PI3K) pathway promotes cancer cell proliferation and survival., These studies have revealed a novel mechanism of Trichostatin A action through derecruitment of a repressor from the Luteinizing hormone receptor gene promoter in a PI3K/PKCzeta-induced Sp1 phosphorylation-dependent manner., The acid-unfolded state of the SH3 domain adopts a partly folded conformation through nonnative long-range contacts between the dynamically restricted residues at the amyloid-forming condition., vascular endothelial growth factor expression is induced through the glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and beta-catenin/T-cell factor-dependent pathway in human endothelial cells, These results demonstrate that estradiol positively regulates essential proteins of the IGF signalling pathway., PI3 kinase effectors PKB and PKC(zeta) are also activated by PI3 kinase in a CD14 dependent manner in lipopolysaccharides stimulated human peripheral blood mononuclear cells., PI3K and its product, PIP(3), facilitate bile acid-induced [Ca(2+)](i) responses in pancreatic acinar cells through inhibition of SERCA-dependent Ca(2+) reloading into the ER and that bile acid-induced trypsinogen activation is mediated by PI3K., We propose that PI(3)Kgamma regulates some aspects of neutrophil polarization that are relevant to movement, such as integrin-based adhesion and the accumulation of polymerized (F)-actin at the leading-edge., These data indicate that the aberrant expression of PTEN contributes to the activation of the PI3kinase/Akt pathway and its transcription factor mediators in glioma., PI 3-K signaling pathway suppresses phorbol 12-myristate 13-acetate-induced expression of p21WAF1/Cip1 in human leukemia cells, and that this effect is partly mediated by PKC zeta., This review describes the second-messenger PI3K gamma signalling pathways that are involved in immune responses relevant to the pathogenesis of rheumatoid arthritis and other inflammatory diseases., PI3K is not overexpressed in melanocytic lesions., PAR1 couples to G(i/o) in human platelets and activates phosphoinositide-3 kinase (PI3K)., Elevated and highly expressed levels in both laarge B-cell lymphoma and Hodgkin lymphoma., SCF-enhanced proliferation and invasion of KIT-positive colorectal cancer cells is achieved mainly through the PI3K/Akt pathway., phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis is inhibited by energy depletion via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794, Evidence is presented that PI3K is involved in basic fibroblast growth factor-stimulated fibroblast-collagen matrix contraction., Phosphorylated PIK3 was documented in 15/17 cytokeratin-positive breast cancer samples., Results suggest that aberrant activation of PI3K-Akt pathway may contribute to increased cell invasiveness and facilitate prostate cancer progression., Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells., These results suggest that PLEK2 is involved in actin rearrangement in a PI 3-kinase dependent manner., In macrophages, uPA was found to activate MAP-kinase through PI3 kinase (PI3K), These results suggested that PKB enhanced DNMT1 stability and maintained DNA methylation and chromatin structure, which might contribute to cancer cell growth., mTOR inhibition increases eIF4E phosphorylation through a PI3K-dependent and Mnk-mediated mechanism., These data identify a novel, PI-3K-dependent pathway by which CSF-1 directs delayed caspase activation in monocytes and thereby modulates DC differentiation., Phosphatidylinositol 3-kinase inhibition by LY294002 also enhanced TRAIL-induced apoptosis., phosphoinositide 3-kinase/Akt/eNOS, but not mitogen-activated protein kinase/ERK, signal transduction pathway may be involved in SDF-1alpha mediated migration of endothelial progenitor cells, Migratory response of freshly isolated T cells is dependent on PI3K signals provided predominantly by PI3Kgamma.t he role of PI3K in cell migration is context-dependent and diminishes during ex vivo maintenance., VEGF regulates angiopoietin-Tie2 signaling by inducing proteolytic cleavage and shedding of Tie2 via a novel PI3K/Akt-dependent pathway., IFNalpha-induced apoptosis requires activation of ERK1/2, PKCdelta, and JNK downstream of PI3K and mTOR, and it can occur in a nucleus-independent manner, thus demonstrating that IFNalpha induces apoptosis in the absence of de novo transcription., human betaARs undergo a process of intracellular sequestration that is dynamically reversed after LVAD support. Importantly, mechanical unloading leads to complete reversal in PI3Kgamma and betaARK1-associated PI3K activation., Cyclin G2 expression is modulated by HER2 signaling through multiple pathways including phosphoinositide 3-kinase, c-jun NH(2)-terminal kinase, and mTOR signaling., These data suggest that the PI3K/Akt and mTOR/p70S6K signaling pathways are essential for adipogenesis of human mesenchymal stem cells., Signal transduction pathways underlying the enhanced cell migration reveal that the IGF-I-IGFBP-VN complex stimulates a transient activation of the ERK/MAPK signaling pathway and a sustained activation of the phosphatidylinositide 3-kinase/AKT pathway., although PI3K can enhance early responses to the bacterial chemoattractant fMLP, it is not required for migration towards this chemoattractant, PI-3K/Akt signaling pathway participates in P2Y receptor-stimulated prostate cancer invasion by enhancing cell motility, rather than up-regulating MMP-2 and MMP-9 activities., These results suggest that caffeine has a cytoprotective effect due to the activation of the PI3K/Akt pathways in SH-SY5Y cells., Association of a functional missense polymorphismwith colon cancer risk in a population-based case-control study. [review], TNF-alpha overrides the G2/M checkpoint in keratinocytes and allows for some cells containing unrepaired cyclobutane pyrimidine dimers to enter the cell cycle. TNF-alpha seems to be dependent on PI3K-Akt activation., These data show that Hsp27 antagonizes Bax-mediated mitochondrial injury and apoptosis by promoting Akt activation via a PI3-kinase-dependent mechanism., Data show that in airway smooth muscle cells from asthmatics, the presence of a strong proliferative stimulus (10% FBS) reduces ERK activation resulting in a shift to the PI 3-kinase pathway., Results identify a molecular mechanism by which activated FGFR2 recruits Cbl in raft micro-domains to trigger PI3K ubiquitination and proteasome degradation, and reveal a role for PI3K/Akt in the control of osteoblast survival by FGFR2 signaling., The PI3K/Akt/mTOR signaling pathway is implicated in the development of cervical cancer., Cav-1 increases the basal and TGF-beta1-induced expression of type I procollagen by regulating two opposite signaling pathways, This study provides a direct link between the growth factor signaling pathways regulated by PI3 kinase/Akt and MAP kinases with Myc-mediated transcription., Transforming growth factor beta induces apoptosis through repressing the phosphoinositide 3-kinase/AKT/survivin pathway in colon cancer cells., The interplay between cancer cell-derived clusterin and IGF-1 may dictate the outcome of cell growth and dormancy during tumorigenic progression., tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases are regulated by phosphorylation, High NG2/MPG expression correlated with multidrug resistance mediated by increased activation of alpha3beta1 integrin/PI3K signaling and their downstream targets, promoting cell survival, High expression of PI3K and Akt are involved in proliferation, malignant transformation, invasion and metastasis of cervical carcinoma., 7-ketocholesterol-induced apoptosis has a role in phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway, GILZ is a mediator of glucocorticoid killing, and is regulated by PI3-kinase/AKT., The role of PI3K pathway activation in thyroid cancer is discussed, with a focus on recent advances., Activation of the PI3K pathway mediated cytoplasmic retention of the Wilms tumor (WTI) protein, which strongly suppressed the hTERT promoter., Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1, The p-EGFR, Our results also indicated that the integrin alphaVbeta3 antibody (LM609) could block the Angptl3-induced protein kinase B phosphorylation., mediates intracellular signals to regulate a variety of cellular responses and its genomic mutations and alterations underlie cancer, viral and/or bacterial infections.[review], MCL-1 expression is activated by Triiodothyronine, which increases its promoter activity by a non-genomic mechanism using the PI3-K signal transduction pathway., required for sphingosine-1-phosphate -induced endothelial cell migration through activation of Rac1, Activation of the PI3K pathway is significantly associated with adverse clinical outcome in renal cell carcinoma., Phosphoinositide 3-kinase/AKT signaling can promote AIB1 stability independently of GSK3 phosphorylation., Data show that M. bovis BCG-induced human beta-defensin mRNA expression in A549 cells is regulated at least in part through activation of signaling proteins of PKC, JNK and PI3K., None of the components in the IGF-1 pathway including IGFBP3, PI3k, and PTEN influence the relation between IRS-1 genotype and prostate cancer risk. Ther is no association between carriage of the variant IRS-1 gene and prostate cancer risk., Datas show that transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab., PIK3IP1 is an important regulator of PI3K in vivo, and its dysregulation can contribute to liver carcinogenesis, PI3K inhibition by Ly294002 alters gene expression in two breast cancer cell lines., Data show that IGF2 activates PI3K and TGFbeta signal pathways during proliferation and differentiation of chondrocytes., The role of PI3K/Akt activity and DNA-PKcs on XRCC1 expression/stabilization, was studied., DIDS-sensitive Cl- channels play a key role in the Low-density lipoprotein-induced cell proliferation of human aortic smooth muscle cells via the activation of Erk1/2 and PI3K/Akt and the upregulation of Egr-1., These results suggest that the BMP-2 acts through PI3K/Akt, which in turn activates IKKalpha/beta and NF-kappaB, resulting in the activations of beta1 integrin and contributing the migration of human chondrosarcoma cells., Endothelin signaling axis activates osteopontin expression through PI3 kinase pathway in A375 melanoma cells., A selective allosteric inhibitor of Akt kinase was used to interrogate a panel of breast cancer cell lines characterized for genetic lesions that activate PI3K/Akt signaling PI3K mutations., Gate control for cell polarization can explain how Rac can be employed for both PI3K-dependent and -independent signaling pathways coexisting in the same cell., The onset of terminal differentiation, while regulated by PI3-kinase and caspases, is not a classical apoptotic process., These findings demonstrate that HAPO induces endothelial cell proliferation through the PI-3K/Akt pathway., Glycine-extended gastrin induced signalling involves a JAK2/PI3-kinase/Akt/NF-kappaB sequence leading to COX-2 transcription., These data show that, in addition to inactivation of 4E-BP1 via hyperphosphorylation, signaling through the PI3K pathway silences 4E-BP1 gene transcription., HuR is a direct transcription target of NF-kappaB; its activation in gastric cancer cell lines depends on phosphatidylinositol 3-kinase/AKT signaling. HuR activation by this pathway has proliferative and antiapoptotic effects on gastric cancer cells., These data demonstrate that integrin/EGFR cross-talk is required for expression of Egr-1 through a novel regulatory cascade involving the activation of the PI3K/Akt/Forkhead pathway., IFN-gamma exerted a delayed suppressive effect on K(+) channels by enhancing iNOS expression and an acute stimulatory effect, which was independent of either NO pathways or phosphorylation mediated by PKA, PKG, and PI3K in renal proximal tubule cells., PDGF-mediated protection also involved the inhibition of gp120-induced release of mitochondrial cytochrome C. Our findings thus underscore the roles of both PI3K/Akt and Bcl family pathways in PDGF-mediated neuroprotection., The direct interaction of PI3Kgamma with PKCalpha forms a discrete regulatory module of N-formylmethionyl-leucyl-phenylalanine-dependent reactive oxygen species production in neutrophils., Altered insulin activation of the PI3K/Akt but not the MAPK pathway precedes and may contribute to development of whole-body insulin resistance and type 2 diabetes in men with low birth weight., NGF induces Mac-2BP expression via the PI3K/Akt/NF-kappaB pathway., These data demonstrated that cell adhesion-mediated PI3K/Akt activation could be one of the important mechanisms of resistance to genotoxin-induced cell death in differentiated epithelial cells., PI3K/Akt/mdm2 signalling pathway can be activated by doxorubicin and suppress apoptosis by promoting phosphorylation of mdm2 in a gastric cancer cell line., inhibition of the PI3K-AKT-mTOR pathway potently increases sensitivity of melanoma cells to chemotherapy, mtDNA depletion prevents detachment-induced apoptosis (anoikis) and promotes migratory capabilities onto basement membrane proteins through upregulation of p85 and p110 phosphatidylinositol 3-kinase (PI3K) subunits, which results in Akt2 activation, Results suggest that inhibition of PI(3)K is a novel mechanism which contributes to 8-prenylnaringenin activity to inhibit cancer cell survival and epidermal growth factor induced proliferation., Pim-1, but not PI3K, plays a major role in IL-5-mediated antiapoptotic signaling in eosinophils., Endometrial stathmin is linked to HIF-1alpha protein accumulation and VEGF expression through the PI3K/Akt signaling pathway and may be involved in regeneration of the endometrium during the menstrual cycle in human uterine cells., TGF-beta may facilitate airway remodelling by promoting VEGF release through the PI3K pathway, rather than via ASM cell proliferation., Data suggest that beta-hydroxy-beta-methylbutyrate (HMB) acts via ERK1/2 and PI3K, as blocking of the PI3K/Akt pathway revealed its requirement in mediating the promotive effects of HMB on muscle cell differentiation and fusion., PI3K signaling, therefore, plays a critical role in regulating protein production during VV infection, at least in part by controlling the abundance and activity of 4E-BP1., Results demonstrate that Ron plays an essential role in maintaining malignant phenotypes of colon cancer cells through regulating mutant PI3K activity., These results suggest that one mechanism of the apoptotic activity of magnolol involves its effect on epidermal growth factor receptor-mediated EGFR/PI3K/Akt signaling transduction pathways., bortezomib overcame TRAIL resistance at clinically achievable concentrations in hepatocellular carcinoma cells, and this effect is mediated at least partly via inhibition of the PI3K/Akt pathway, Snail upregulation by HRG-beta1 is mediated via the PI3K/Akt signaling pathway and Snail plays a key role in HRG-beta1 induced breast cancer cell metastasis through induction of EMT, Impaired PI3K signaling might account for the variability in the responses to ischemic preconditioning of human grafts from deceased donors., Data showed that tumor-associated matrices induced PI3K and beta1-integrin dependent Akt/PKB activity in MDA-MB-231 cells., TNFalpha facilitates the reduction of FLIP(L) protein, which is dependent on the phosphatidylinositol 3-kinase/Akt signaling., IL-6 functions in a cytoprotective manner, in part, by suppressing Bax translocation and dimerization through PI3K/Akt-mediated Bax phosphorylation., PRL up-regulated CHIT-1 expression via PTK, PI3-K, MAPK, and signaling transduction components., Results show that targeted disruption of the cell surface Cripto/GRP78 complex precludes Cripto activation of MAPK/PI3K and Smad2/3 pathways., the formation of LAT-mediated complexes do not appear to depend on PI3K activity, whereas the optimal downstream function of these complexes requires the catalytic function of PI3K, The authors find that the induction of NF-kappaB and phosphatidylinositol 3-kinase activities following HCMV infection was required for the initiation of monocyte-to-macrophage differentiation., dysregulation of the phosphoinositide 3-kinase/Akt/PTEN pathway is relevant to the prognosis in node-negative breast carcinoma, PTEN modulated VEGF-mediated signaling and affected tumor angiogenesis through PI3K/Akt/VEGF/eNOS pathway., Increased expression of PI3K is associated with gallbladder adenocarcinoma., Similar to its function in T cells, CEACAM1 may act as an inhibitory B cell coreceptor, most likely through recruitment of SHP-1 and inhibition of a PI3K-promoted activation pathway., PI-3 kinase activity is necessary for ERK1/2-induced disruption of mammary epithelial architecture, Loss of PTEN function in breast cancer can occur either by mutation or reduction of PTEN expression in almost half of sporadic breast tumors., inhibition of phosphatidylinositol-3 kinase (PI3K) reversed phospholipid transfer protein -induced increase in levels of GSK3 beta phosphorylated at serine 9, The constitutive activation of the PI3K-Akt pathway in Fanconi anaemia cells upregulates the expression of IL-1beta., Results show that this unique and specific bacterial entry process is dependent on the cooperation and activation of Rho family GTPase Cdc42, PI3K, and Akt., Targeting NRAS alone or both BRAF and CRAF in combination or both BRAF and PIK3CA together showed delay in tumor growth., The EGF/PI3K/STAT3 signaling is identified as an essential pathway regulating VEGF and leptin expression in EGF-responsive colon cancer cells., Asef and APC function downstream of HGF and PI3-kinase, and play critical roles in growth factor-mediated regulation of cell morphology and migration, Data show that IL-4 receptors are functionally competent in pancreatic beta-cells and that they signal via PI3K and JAK/STAT pathways., Data indicate that PI3K inhibitor, LY294002, almost completely blocked Lf(Fe(3+))-induced Akt activation, and prevented the cytoplasmic localization of p27(kip1)., Results provide evidence for the potential application of roscovitine/wormannin combination in clinical cancer treatment by repressing PI3K/Akt pathway., p110gamma activity plays an important role in maintaining a membrane-docked, readily releasable pool of secretory granules in insulinoma and human beta-cells, Data show that inhibition of NF-kappaB or PI3K potently enhanced cisplatin cytotoxicity in cells with endogenous or genetically induced low MKP1 levels., Studies indicate inhibition of the PI3K/AKT/mTOR pathway is not only a potential first-line therapeutic strategy in ovarian cancer but also could be used in recurrent disease as a means of reversing acquired chemotherapy resistance., Results demonstrated that the inhibition of spontaneous B cell apoptosis by CpG DNA was correlated to up-regulation of Bcl-xL, IAP and down-regulation of p53 and caspase 3 mediated through PI3K/AKT signaling., Data provide a basis for rational combination of MEK and PI3K inhibitors in basal-like cancers with both intact and deleted PTEN., Data elucidate a novel signaling network that leads to increased IL-8 production through p38 mitogen-activated protein kinase-dependent phosphatidylinositol 3-kinase activation in response to proteasome inactivation., over-expression of DIXDC1 might target p21 and cyclin D1 to promote colon cancer cell proliferation and tumorigenesis at least partially through activation of the PI3K/Akt pathway., Mal specifically connects TLR2/6 to PI3K activation, PIP(3) generation and macrophage polarization., Data show that IGFBP-3 is regulated by the PI3-kinase/AKT and MAPK/ERK1/2 pathways., Data show that aberrant expression of ErbB2, ErbB3 and ErbB4 in the two resistant cell lines, suggesting the existence of an autocrine loop leading to constitutive activation of MAPK and PI3K/Akt survival pathways., Results show interaction between CCR7 and its ligand CCL19 induces phosphorylation of mTOR and its target p70s6k. This phosphorylation is abolished by inhibition of CCR7 and PI3K/Akt, indicating that mTOR is involved in the CCR7-PI3K cascade., Data suggest an interaction between COX-2 enzymatic activity and PI3Kinase/AKT signaling pathway in EOC., Data show that with SF1126 treatment, caspase 3 and PARP proteins were cleaved, survivin was down-regulated, and inhibition of PI3-kinase was confirmed by reduced phosphorylation of Akt., PI3Kgamma regulates tumor cell adhesion through activation of CXCL12., Results suggest that bFGF increases the Mg(2+)](i) from the intracellular Mg(2+) stores through the tyrosine kinase/PI3K/PLCgamma-dependent signaling pathways., The gene copy number of PIK3CA is frequent genetic alteration that contributes to MCL progression. PIK3CA is a promising therapeutic target in MCL., These results identify nNOS as a target gene of a novel RA/PI3K/Akt/DAX1-dependent pathway in human neuroblastoma cells, These data indicate PI3Kgamma is an important regulator of fibroblast-mediated joint destruction in rheumatoid arthritis., These findings identify TAPP2 as a novel link between PI3K signaling and the cytoskeleton with potential relevance for leukemia progression, AP-1 activity in prostate cancer cells mediates EGF-R and PI3K signalling, is essential for their proliferation, and confers protection against radiation-induced cell death, Studies provide models for Ras in association with Raf kinase, RalGDS and PI3Kalpha and PI3Kgamma., Data show that B[a]PDE increases cyclin D1 expression, and activate the PI3-kinase/Akt/MAPK- and p70s6k pathway in Beas-2B bronchial epithelial cells., Data show that stimulation of HIF-1alpha transcription by the ND6 mutation was mediated by overproduction of reactive oxygen species (ROS) and subsequent activation of phosphatidylinositol 3-kinase (PI3K)-Akt and protein kinase C (PKC) signaling pathways., Data suggest that investigation of the mechanisms of abnormal RAS and phosphoinositide-3 kinase pathway activation in erythroblasts may contribute to the understanding of the molecular pathogenesis of PV., BMP-2 promotes motility and invasion of gastric cancer cells by activating the PI-3 kinase/Akt signal pathway., Data show that RNA silencing of choline kinase in HeLa cells completely abrogates the high concentration of phosphocholine, which in turn decreases phosphatidylcholine, phosphatidic acid and signaling through the MAPK and PI3K/AKT pathways., Oscillatory shear stress induces osteoblast-like cell proliferation through activation of alpha(v)beta(3) and beta(1) integrins and synergistic interactions of FAK and Shc with PI3K, leading to the modulation of ERK and Akt/mTOR/p70S6K pathways., The key signaling molecules in the PI3K signaling cascade, the abnormalities known to occur in thyroid cancer, and the potential for therapeutic targeting of PI3K pathway members are discussed., Data show that DAB2IP is a potent growth inhibitor by inducing G(0)/G(1) cell cycle arrest and is proapoptotic in response to stress, and that DAB2IP can suppress the PI3K-Akt pathway and enhance ASK1 activation leading to cell apoptosis., Elevated expression of p53-R175H mutant may exert gain-of-function activity to activate the EGFR/PI3K/AKT pathway and thus may contribute to the invasive phenotype in endometrial cancer., Hepcidin mRNA expression in vitro is highly sensitive to the presence of serum factors and PI3 kinase inhibition and parallels TfR2 expression, Data show 5-HT can induce activation of two interrelated signaling pathways, Erk1/2 and PI3K/Akt to induce proliferation, migration, and differentiation., Data show that the cleavage of MST1 is inhibited by the phosphatidylinositol 3-kinase/Akt pathway., Data show that suppression of PUMA through the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/p53 axis in the intestinal stem cells as a novel molecular mechanism of growth factor-mediated intestinal radioprotection., Increased expression of Lewis y antigen plays an important role in promoting cell proliferation through activating PI3K/Akt signaling pathway in ovarian carcinoma-derived RMG-I cells., Genetic and biochemical analysis of these "hot-spot" mutations in human p110alpha, is reported., These data elucidate the role of PLCgamma1 in FGF-2 signalling in human umbilical vein endothelial cells demonstrating its key role in FGF-2-dependent tubulogenesis., Data show that c-mip interacts with the p85 subunit of PI3 kinase and inactivates Lck, which results in Erk1/2 and p38 MAPK activation., Heat shock protein 70 (Hsc70) plays a significant role in vascular endothelial cells via the phosphatidylinositol 3-kinase/Akt pathway., Studies indicate that the PI3K/Akt/mTOR pathway plays a critical role in breast cancer development and resistance to traditional anti-tumor strategy., genomic alterations in the Ras-PI3K pathway are widespread in endometrial carcinomas, regardless of the type of genomic instability, Data show that PI3K activation and PIP3 production lead to recruitment of the PKB/beta-arrestin/PDE4 complex to the membrane via the PKB PH domain, resulting in degradation of the TCR-induced cAMP pool and allowing full T-cell activation to proceed., The PI3K/Akt pathway may play an inhibitory role in inflammatory mediators-induced human vascular smooth muscle cell calcification through regulating alkaline phosphatase expression., These results indicate that human nasal airway fibroblasts strongly induce BLyS-expression and production by poly(I, Data report that activation of P2Y(2) receptors by extracellular UTP inhibits the IGF-I-induced p110alpha-PI3K activation., Data show that the expression of tenascin-C is induced in immune myeloid cells, and its synthesis is transcriptionally regulated and requires the specific activation of AKT/PI3K and NF-kappaB signaling pathways., phosphoinositide 3-kinase and RAS-RAF pathways drive the activity of RAF265, a novel RAF/VEGFR2 inhibitor, and RAD001 (Everolimus) in combination, molecular cross-talk between the MKP-1, p38 MAPK and PI3K pathways promotes resistance to PI3K inhibitors in hilar cholangiocarcinoma cells., These results suggested that although hypercholesterolemic serum could not change the expression of ZO-1, it could change the distribution and increase the permeability in endothelial cells through PI3K signaling pathway., The activation of the PI-3K/mTOR/translational pathway is important for IFNgamma-mediated VEGF expression in retinal pigmented epithelial cells., PI3-kinase exerts a major morphogenetic impact in simple cultured epithelia through preservation of cell height., Activation through CD160 leads to PI3K-dependent chronic lymphocytic leukemia protection from spontaneous in vitro apoptosis, as well as cellular activation with cell cycle progression and cytokine production., Data indicate that compound 26 (PKI-587) has shown excellent activity as highly efficacious PI3K/mTOR inhibitor., Data show that each of the five domains of phosphoinositide 3-kinase gamma is capable of binding anionic phospholipids to varying degrees, depending on the charge of the anionic substrate., PI3K/Akt prevents the malignant phenotype of HCT-116 colorectal cancer cells., Data show that significant expression of PI3Kgamma in neuroblastoma patient biopsies and tumor cell lines was detected., Data show that the coexpression of HSP90 with PI3K-p110alpha or expression of HSP90 along with PTEN loss has a potential as a molecular prognostic marker to predict early relapse in patients with invasive breast cancers., AR mediates EGF- and bFGF-induced colon cancer cell proliferation by activating or expressing G(1)-S phase proteins such as E2F-1, cdks, and cyclins through the reactive oxygen species/phosphoinositide 3-kinase/AKT pathway., PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase, Data identify DEAF1 as an interactor and in vitro substrate of GSK3A and GSK3B that interacts with the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway., These results suggest that deregulation of the PI3K pathway in the bronchial airway epithelium of smokers is an early, measurable, and reversible event in the development of lung cancer., prostate cancer cell lines differentially express phosphoinositide-3 kinase (PI3K) catalytic subunit isoforms and dedicator of cytokinesis 2, Angiotensin II increased Akt phosphorylation and PI3K activity in cultured hypertrophic scar fibroblasts in a dose- and time-dependent manner., These findings suggest that angiotensin II plays a role in the growth of angiotensin II type I receptor-positive breast cancer cells through PI3-kinase/Akt pathway activation., PI3K might play a role in silica-induced DNA double strand break repair by regulating the expression levels of Ku70 and Ku80 in lung fibroblasts., PI3K-PKB-mTOR signaling plays a crucial role in the development of functional CD34-derived myeloid Dendritic cells, Increased PI3K is associated with multiple myeloma., Data demonstrate that PI3K/Akt pathway regulates the expression of DNMT3B at transcriptional and post-transcriptional levels, which is particularly important to understand the effects of PI3K/Akt and DNMT3B on hepatocarcinogenesis., Data suggest that the induction of apoptosis by tanshinone I in leukemia cells is mainly related to the disruption of Deltapsim, inactivation of PI3k/Akt signaling pathway, upregulation of Bax expression, and the activation of caspase-3., The phosphorylation of Thr159 in Vps34 is a key regulatory mechanism that controls the class III PtdIns3 kinase activity in cell-cycle progression, development, and human diseases including neurodegeneration and cancers., Role of germ line genetic variations in the PI3K-AKT-mTOR pathway genes as predictors of bladder cancer metastasis and invasiveness., PDCD4 regulates TRAIL sensitivity in gastric cancer cells by inhibiting the PI3K/Akt signaling pathway., The activated PI3K/Akt/COX-2 signal transduction pathway was found to be the main cause for decline in radiosensitivity in HeLa cells., The bFGF-FGFR1-PI3K-Rac1 pathway in the bone microenvironment may have a significant role in the invasion and metastasis of Ewing sarcoma., Collectively, these data suggested that, in oral epithelial cells, the herpes simplex virus 1-induced PI3K/Akt activation was involved in the regulation of apoptosis blockage and viral gene expression., Studies indicate that targeting the deregulated PI3K/PTEN-Akt signaling axis has currently emerged as one of the major tenets in anticancer drug development., Our study suggests that the type III PI3 kinase integrates diverse signals to regulate cellular levels of autophagy, and that autophagy and cell proliferation may represent two alternative cell fates that are regulated in a mutually exclusive manner., Data indicate that stathmin is a target of the PI3K/Akt pathway in cervical cancer cells., The results above collectively show that C/EBPepsilon participates in all-trans retinoic acid induction of PI3Kgamma., FOXO3a is in a constant inactive state due to its cytoplasmic localization, and that neither PI3K/Akt nor extra-signal-regulated kinase-specific inhibition resulted in its nuclear translocation., demonstrate that alphaVbeta3 ligation results in sustained increases of PI3 kinase/Akt-dependent binding of transcription factor NF-kappaB to DNA., Bile salt-induced hepatocyte apoptosis is partly mediated via a PI3K p110gamma dependent signaling pathway, potentially involving JNK., Phosphoinositide-3-kinase gamma plays a major role in the induction of chemotaxis in platelet-activating factor-stimulated human eosinophils., VEGFR1 contributes to E. coli K1 invasion of human brain microvascular endothelial cells through the phosphatidylinositol 3-kinase/Akt signaling pathway., These findings demonstrated that PI3K-mediated actin rearrangements are required for Cronobacter sakazakii invasion of human brain microvascular endothelial cells., An inhibitor of PI3K (LY294002) blocked HSV-1 entry and the blockage was cell-type- and viral glycoprotein gD receptor-independent., levated PI3K pathway activity in acute myelogenous leukemia, Studies indicate that molecular mechanisms underlying phyagocyytossis are starting to point to the interplay between two families of crucial proteins, Platelet migration was stimulated by SDF-1 through PI3 kinase dependent mechanism., These results show that PI 3-kinase regulation of mRNA stability, predominantly mediated by BRF1, plays a major role in regulating gene expression., C. jejuni activates a PI3K/Akt-dependent anti-inflammatory pathway in human intestinal epithelial cells., Data demonstrate an important role for the PI3-kinase-Akt pathway in intracellular transport of surfactant protein A receptor P63., Data show an in vitro link between phosphoinositide 3-kinase-mediated HOXA9/HOXA10 expression, and a drug-resistant, progenitor cell phenotype in MGMT-independent pediatric glioblastoma., Findings show that oncogenic factors activating the phosphoinositide 3-kinase/Akt pathway can regulate alternative splicing of Casp9 via a coordinated mechanism involving the phosphorylation of SRp30a., PI3K-PDK1 signaling is essential for viability, MALT1 protease activity, and NF-kappaB activation in activated B-cell-like diffuse large B-cell lymphoma cells that carry mutations in the BCR proximal signaling adaptor CD79B., This indicates that not only MAPK activation, but PI3Kgamma protein kinase activity in general is localized in the cytosol., Data demonstrate that AG/UAG attenuation of ISO-induced lipolysis involves PI3Kgamma/AKT and PDE3B., p110gamma anchors protein kinase A (PKA) through a site in its N-terminal region. Anchored PKA activates PDE3B to enhance cAMP degradation and phosphorylates p110gamma to inhibit PIP(3) production, Once activated, p110gamma promotes inside-out activation of a single integrin, alpha4beta1, causing myeloid cell invasion into tumors., PI3Kgamma, a PI3K isoform exhibiting restricted tissue distribution, is strictly required for signaling from the KSHV-encoded vGPCR oncogene to Akt/mTOR., Activation of the PI3K/Akt/mTOR pathway correlates with tumour progression and reduced survival in patients with urothelial carcinoma of the urinary bladder., role of p110gamma as a promoter of HCC proliferation and unveil an important cell cycle regulation function of this molecule., our study reveals a novel link between NF-kappaB and PI3K/Akt and establishes c-FLIP as an important regulator of FasL-mediated cell death., Ras-p110gamma interaction is necessary for efficient beta-selection-promoted proliferation but is dispensable for the survival or differentiation of thymocytes., protection from insulin resistance, metabolic inflammation, and fatty liver in mice lacking functional PI3Kgamma is largely consequent to their leaner phenotype, A novel regulatory role of p101 in the activation of PI3Kgamma., The expression levels of PI3K protein and mRNA in esophageal squamous cell carcinoma tissues are significantly increased and PI3K plays a role in the carcinogenesis and development of ESCC., findings suggest that PIK3CG function impacts the severity of the intraparenchymal bleed in patients with intracerebral hemorrhage, Culturing spermatogonia in vitro at 37 degrees C could inhibit the expression of PI3K and c-kit, and lead to the mutation of the c-kit gene., a novel mechanism that links PI3Kgamma activity with chemotaxis and superoxide production in G-protein coupled receptor signaling., PI3Kgamma plays a key role in ipopolysaccharide-induced ROS generation in alveolar epithelial cells, thereby activating NF-kappaB, PI3K/AKT/mTOR signalling components appear to be differentially implicated in urothelial tumorigenesis and, with the exception of p85aPI3K, are unrelated to the PIK3CA or AKT1 mutational status., Class II enzyme PI3K-C2beta and class IB isozyme p110gamma mainly regulate the S1P- and high density lipoprotein (HDL)-dependent endothelial cell (EC) migration and PI3K-C2alpha primarily controls EC survival, kinase-independent function of PI3Kgamma could directly inhibit GSK-3 function by preventing the PP2A-PPMT-1 interaction and that this inhibition of GSK-3 was independent of Akt., Assessed the expression of class I PI3K p110 isoforms in idiopathic pulmonary fibrosis lung tissue as well as in tissue-derived fibroblast cell lines., Upregulated phosphoinositide 3-kinase gamma is a target to suppress breast cancer cell migration and invasion., Ablating the interaction of PI3Kgamma with Gbetagamma heterodimers attenuates signaling, chemotaxis, and transformation driven by a GPCR agonist in cell lines., PI3Kgamma plays an important role in the development of eosinophilic inflammation a, Binding of the HSV-1 envelope initiates the epidermal growth factor receptor EGFR-PI3K signaling pathway, which leads to virus-induced early cofilin phosphorylation and F-actin polymerization., The data indicate that PI3Kgamma has a critical role in cAMP-mediated inflammatory hypernociception and analgesic signalling via mu-opioid receptors and PI3K/Akt in neuronal cells., Data indicate class of benzothiazoles as inhibitors of phosphoinositide 3-kinase gamma., phosphatidylinositol 3-kinase gamma has a role in insulin secretion induced by glucose-dependent insulinotropic polypeptide, PI3Kgamma-induced VEGF expression was reduced when the human tocopherol-associated protein 1 (hTAP1/SEC14L2) was overexpressed suggesting formation of an inactive PI3Kgamma/hTAP1 heterodimer., The interaction between PI3Kgamma and CNGA1 does not appear to play a role in regulation of CNG channel activity, but PI3Kgamma uses CNGA1 as an anchoring module to achieve close proximity to its substrate to generate D3-phosphoinositides, increased susceptibility of individuals with COPD to influenza likely results from impaired antiviral responses, which are mediated by increased PI3K-p110alpha activity., Our findings suggest that p84 binding to p110gamma may represent a novel negative feedback signal that terminates PI3Kgamma activity., Mfng is an oncogene acting through Notch-mediated induction of Pik3cg., findings suggest that miR-502 functions as a tumor suppressor in HCC via inhibition of PI3KCG, supporting its utility as a promising therapeutic gene target for this tumor type, data argue for differential regulatory functions of the non-catalytic subunits and a specific Gbetagamma-dependent regulation of p101 in PI3Kgamma activation., Findings suggest the pathophysiological role of phosphoinositide 3-kinase gamma (PI3Kgamma) in atherogenesis., Diminished expression of p110gamma in pulmonary vascular endothelial cells of patients with acute respiratory distress syndrome suggests that impaired p110gamma-FoxM1 vascular repair signaling is a critical factor in persistent leaky lung microvessels in ARDS.,
SP_COMMENT catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate., enzyme regulation:Activated by both the alpha and the beta-gamma G proteins., function:3-phosphorylates the cellular phosphoinositide PtdIns-4,5-biphosphate (PtdIns(4,5)P2) to produce PtdIns-3, 4,5-triiphosphate (PtdIns(3,4,5)P3). Links G-protein coupled receptor activation to the secondary messenger PtdIns(3,4,5)P3 production., pathway:Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis., similarity:Belongs to the PI3/PI4-kinase family., similarity:Contains 1 PI3K/PI4K domain., subunit:Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit., tissue specificity:Pancreas, skeletal muscle, liver and heart.,