Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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protein phosphatase 1 regulatory subunit 12B(PPP1R12B) protein phosphatase 1 regulatory subunit 12B(PPP1R12B) Related Genes Homo sapiens
CHROMOSOME 1,
CYTOBAND 1q32.1,
ENSEMBL_GENE_ID ENSG00000077157,
GENERIF_SUMMARY Results describe the characterization and function of MYPT2, a target subunit of myosin phosphatase in heart., analysis of the interaction between the coiled coil leucine zipper of cGMP-dependent protein kinase Ialpha and the C terminus of the myosin binding subunit of the myosin light chain phosphatase, PPP1R12B is associated with childhood asthma in a Russian population.,
SP_COMMENT caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data., function:Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus., similarity:Contains 5 ANK repeats., subcellular location:Along actomyosin filaments and stress fibers., subunit:PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12B mediates binding to myosin. Isoform 3 and isoform 4 bind PPP1R12A, but not isoform 1 of PPP1R12B itself. Binds IL16., tissue specificity:Detected in skeletal muscle, fetal and adult heart, brain, placenta, kidney, spleen, thymus, pancreas and lung. Isoform 3 and isoform 4 are heart specific.,