Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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v-myc avian myelocytomatosis viral oncogene homolog(MYC) v-myc avian myelocytomatosis viral oncogene homolog(MYC) Related Genes Homo sapiens
CYTOBAND 8q24.21,
GENERIF_SUMMARY Review, We have located a region in the c-myc promoter that is required for the complete activation by the immunoglobulin heavy chain gene enhancer, In Situ studies demonstrate enhanced mRNA expression of the proto-oncogene c-myc in stenotic venous bypass grafts., c-Myc physically interacts with Smad2 and Smad3 involved in TGF-beta signaling.c-Myc promotes cell growth and cancer development partly by inhibiting the growth inhibitory functions of Smads, Uteroglobin promoter-targeted c-MYC expression in transgenic mice cause hyperplasia of Clara cells and malignant transformation of T-lymphoblasts and tubular epithelial cells, initiates illegitimate recombination of ribonucleotide reductase 2 gene, Acute hyperglycaemia induces an up-regulation of seven major genes, four of which were not previously reported in the literature. Northern blot analyses, performed on these 4 genes, confirm macroarrays results for alphav, beta4, c-myc, and MUC18., Activation of c-MYC and c-MYB proto-oncogenes is associated with decreased apoptosis in tumor colon progression., amplification in acute nonlymphocytic leukemia, Repression of alpha-fetoprotein gene expression under hypoxic conditions in human hepatoma cells, The cytoplasmic domain of gp130 is involve the induction of c-myc expression and the cell proliferation in Meg-01 cell., Retinoic acid-induced cell cycle arrest of human myeloid cell lines is associated with sequential down-regulation of c-Myc and cyclin E., Scatter factor/hepatocyte growth factor stimulation of glioblastoma cell cycle progression through G(1) is c-Myc dependent and independent of p27 suppression, Cdk2 activation, or E2F1-dependent transcription., complex with Nmi and BRCA1 inhibits c-Myc-induced human telomerase reverse transcriptase gene promoter activity in breast cancer, c-myc-induced apoptosis in polycystic kidney disease is independent of FasL/Fas interaction., The N-myc and c-myc downstream pathways include the chromosome 17q genes nm23-H1 and nm23-H2, estrogen and Myc negatively regulate EphA2 expression in mammary epithelial cells, A novel form of the RelA nuclear factor kappaB subunit is induced by and forms a complex with this proto-oncogene protein, overexpressed in acute myeloid leukemia while translocations associated with this gene are absent, The proto-oncogene c-myc in hematopoietic development and leukemogenesis, c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function, Overexpression of c-myc mRNA was found in an Achilles tendon clear cell sarcoma and may have a role in its malignant progression., TRRAP binding and the recruitment of histone H3 and H4 acetyltransferase activities are required for the transactivation of a silent TERT gene in exponentially growing human fibroblasts by c-Myc or N-Myc protein., Effects of fluid shear stress on expression of proto-oncogenes c-fos and c-myc in cultured human umbilical vein endothelial cells., the in vitro effects of iron on the proliferation of a primary, human synovial fibroblast cell line and the involvement of c-myc in this process as a model for c-myc proto-oncogene expression in hemophilic synovitis, role of c-Myc increasing susceptibility to tumor necrosis factor mediated apoptosis, Myc activates transcription by stimulating elongation and that P-TEFb is a key mediator of this process, dysregulated beta-catenin may cause a transcriptional upregulation of the c-myc gene; the c-Myc protein expression appears to be further regulated by posttranscriptional mechanism(s) during neoplastic progression in colorectal adenocarcinomas, C-Myc may be a downstream target of anaplastic lymphoma kinase (ALK)signaling and its expression a defining characteristic of ALK-positive anaplastic large cell lymphomas, c-myc induces programmed cell death in a process requiring glutathione in human tumor cells, Amplifications of c-myc and CCND1 are associated with detrusor-muscle-invasive transitional cell carcinoma, results reveal a novel cytoskeletal function for Myc and indicate the feasibility of quantitative whole-proteome analysis in mammalian cells, This review describes the role of MYC in tumor progression, c-myc and c-erbB2 amplification in breast cancer, Marked intratumoral heterogeneity of this and cyclinD1 but not of c-erbB2 amplification in breast cancer, Beta-catenin mutations correlate with over expression of C-myc and cyclin D1 Genes in bladder cancer., CD19+ cells from transgenic mice with a lamba-humanMYC construct driven by B-cell elements overexpressed both C-MYC and protein kinase A-Cbeta., c-Myc promotes cell survival under stressful conditions., the mechanism of apoptosis induced by c-myc gene in oral squamous cell, Reduction in the c-myc protein was correlated with neck metastasis in nasopharyngeal carcinoma., c-myc translation is regulated by hnRNP C via internal ribosomal entry site binding, c-Myc binds to TFIIIB, a pol III-specific general transcription factor, and directly activates pol III transcription, examination of functionality of basic domains compared with Mad, repression of differentiation-induced p21 expression through Miz-1 may be an important mechanism by which Myc blocks differentiation, Expression of c-Myc in primary central nervous system diffuse large B-cell lymphoma may be a prognostic marker for poor overall survival., results show that Ser727/Tyr701-phosphorylated Stat1 plays a key role as a prerequisite for the ATRA-induced down-regulation of c-Myc; cyclins A, B, D2, D3, and E; and simultaneous up-regulation of p27Kip1, associated with arrest in the G0/G1 phase, results indicate that Nijmegen breakage syndrome 1 gene (NBS1) is a direct transcriptional target of c-Myc and links the function of c-Myc to the regulation of DNA double-strand break repair pathway, c-myc binds to the hTERT promoter and is involved in the pathway for regulation of cellular immortalization through BRCA1, A detailed structure-function analysis of the Myc N-terminal domain in deletion & point mutants studied their ability to induce cell cycle progression, apoptosis & transformation as well as repress & activate endogenous target genes., Up-regulation of c-Myc protein could disturb the signaling pathway of ceramide & sphingosine, endogenous modulators mediating apoptosis. c-Myc protein is a mediator of cytoprotective effect of PKC pathway in HL-60 cells., Myc down-regulation might directly mediate the growth-inhibitory properties of 3'-5' RNA exonuclease, inverse correlation between TMEFF2 and c-Myc expression, findings suggest that Myc-mediated functions can be negatively regulated by KRAB box containing zinc finger protein (Krim-1), MYC recruits the TIP60 histone acetyltransferase complex to chromatin, c-myc gene is regulated by nitric oxide via inactivating NF-kappa B complex, c-Myc together with its heterodimeric partner, Max, occupy >15% of gene promoters tested in Burkitt lymphoma cells. Overexpressed c-Myc plays a role in global transcriptional regulation in some cancer cells and functions in malignant transformation., the PI3K/p70 S6K/c-Myc cascade plays an important role in neutrophilic proliferation in HL-60 cells., Induction of hTERT by Myc/E6 was independent of Myc phosphorylation at Thr-58/Ser-62 within the transactivation domain. E6 associates with Myc complexes & activates a Myc-responsive gene, hTERT., Inhibition of this oncoprotein limits the growth of human melanoma cells by inducing cellular crisis, expression of MYC oncogene is reduced at the mRNA level and MYC protein has an increased half-life in Adenovirus infected Hela cells resulting in constant steady state levels., results demonstrate that MYC directly stimulates transcription of the Werner syndrome gene,WRN; propose that WRN up-regulation by MYC may promote MYC-driven tumorigenesis by preventing cellular senescence, hematopoietic growth factors induce cell cycle progression via internal ribosome entry site-mediated translation of c-myc though the PI3K pathway in human factor-dependent leukemic cells, overexpression of MYC disrupts the repair of double-strand DNA breaks, resulting in a several-magnitude increase in chromosomal breaks and translocations, the mutated version of the c-myc IRES that is prevalent in patients with multiple myeloma bound hnRNPK more efficiently in vitro and was stimulated by hnRNPK to a greater extent in vivo., p53 and c-Myc expression may have a role in regulation of telomerase activity in ovarian tumours, c-Myc regulates cell growth and proliferation by the coordinated induction of cdk activity and rRNA processing, contribution of JNK to the regulation of c-Myc protein stability under normal growth conditions, identified an evolutionarily conserved boundary at which the c-myc transcription unit is separated from the flanking condensed chromatin enriched in lysine 9-methylated histone H3, PLZF expression maintains a cell in a quiescent state by repressing c-myc expression and preventing cell cycle progression., we review Myc-induced pathways that contribute to the apoptotic response., These data also suggest that location of intragenic PTEN mutations and their coexistence with the CMYC amplification may play a crucial part in the development of various subtypes of endometrial carcinoma., Data suggest that cyclin dependent kinase 4 is involved in the development of tobacco-mediated oral carcinogenesis, and that c-myc expression is absent in normal and high in later stages of oral cancer development., c-myc may have a role in the development of Burkitt's lymphoma, through an RNA-mediated gene silencing pathway, c-Myc may control the activity of multiple signal pathways involved in cellular transformation by induction of HSP90A, Aurora-A induces telomerase activity and hTERT by up-regulation of c-Myc, MYC has a role in tumor progression in BRCA1-associated breast cancers, c-Myc expression is regulated by cytosolic phospholipase A2 in a process that involves B-myb, c-Myc does not play a major role in gene regulation of the catalytic subunit of telomerase (hTERT) in human hepatocellular carcinoma., c-Myc can support self-renewal of HSCs as a downstream mediator of Notch and HOXB4., Myc is an integral part of a novel HIF-1alpha pathway, which regulates a distinct group of Myc target genes in response to hypoxia., Levels of both c-myc and beta-catenin increased in Cyr61 stably transfected H520 cells., Gene amplification of c-myc may play key role in regulating expression of its mRNA and protein in high-grade breast cancers, c-Myc can specifically recognize the HIV-1 initiator element surrounding the start site of transcription and linker scanning mutagenesis experiments confirmed a loss of c-Myc-mediated repression in the absence of this region, High nuclear expression of c-myc is correlated with locally advanced colorectal cancer, C-Myc over-expression was significantly associated with high sVEGF and normal sFlt-1 level in DLBCL patients, suggesting a complex interrelationship between c-Myc oncogene expression and angiogenic regulators, expression of c-Myc protein is increased not only in uterine cervix cancer but also in the premalignant lesions, Translocations involving the MYC locus were detected in six cases of B-cell lymphoma, five of them derived from a MYC/IGH juxtaposition and one from a translocation involving a non-IG gene partner., c-myc transactivates rat and human adrenomedullin genes and accelerates the degradation rate of adrenomedullin mRNA., c-myc mRNA was detected in 18 of 59 cases, and was associated with shorter patient survival times on both univariate and multivariate analyses. The presence of c-myc mRNA was also significantly associated with tumor anaplasia., cMyc is a target of ARF tumor suppressor, Myc binds well to conserved canonical E boxes, but not nonconserved E boxes. Results show Myc is an important regulator of glycolytic genes, suggesting that MYC plays a role in a switch to glycolytic metabolism during cell proliferation or tumorigenesis., c-myc oncogene has not shown to be a prognostic factor for laryngeal squamous cell carcinoma of the supraglottic larynx., c-MYC activated transcription from the upstream binding factor promoter, A prolactin signalling cascade in W53 cells involves Src kinases that mediate stimulation of c-Myc expression., There is no obvious correlation between breakpoint locations within the immunoglobulin H locus and the amount of MYC mRNA., polyamine-induced nuclear c-Myc interacts with Max, binds to the specific DNA sequence, and plays an important role in stimulation of normal intestinal epithelial cell proliferation., p53-independent checkpoint to prevent c-Myc-mediated tumorigenesis, Inhibition of c-Myc (and c-Raf-1) significantly reduced the growth and invasiveness of rheumatoid arthritis synovial fibroblasts in the SCID mouse model., There was a significant positive correlation between the levels of c-myc mRNA expression and the occurrence of apoptosis in 59 hepatocellular carcinomas., novel iron-dependent cell cycle regulatory mechanism involving modulation of translocated c-myc gene expression, c-myc downregulation and release from the endogenous p21WAF1/CIP1 promoter contributes to transcriptional activation of the p21WAF1/CIP1 in HeLa cells, Myc is essential for the regulation of a large number of growth-related genes in B cells, and cannot be replaced by other serum-induced factors., CREB binding protein is essential for keeping c-myc in a repressed state in G(1) and thereby preventing inappropriate entry of cells into S phase., c-Myc antagonized the induction of p21Cip1 mediated by oncogenic H-, K-, and N-Ras and by constitutively activated Raf and ERK2, chromosomal c-myc replicator activity can be altered by transcription factors that induce transcription, Myc stimulates VEGF production by a rapamycin- and LY294002-sensitive pathway., LMP1 activates telomerase via c-myc, c-myc expression is regulated by TFIIH using an expanded proximal promoter, the increased affinity for the duplex state due to mutation in the nuclease hypersensitive element could play a functional role in the aberrant regulation of c-myc, c-myc and mad1 can regulate the hTERT transcript in a different manner in hTERT positive cells, but not in normal cells, the entire N and C-terminal regions of c-Myc transactivation domain act in concert to achieve high specificity and affinity to two structurally and functionally orthogonal target proteins, Tyrosine residues become phosphorylated following receptor engagement and, as such, form two Grb2 binding sites, which have been proposed to be differentially coupled to Myc-dependent survival., This paper reports the first solution structure of a G-quadruplex found to form in the promoter region of an oncogene (c-MYC)., frequency and chromosomal features of this der(8)t(8;14;18) in a series of acute leukaemias and malignant lymphomas, c-Myc coordinates the activity of all three nuclear RNA polymerases, and thereby plays a key role in regulating ribosome biogenesis and cell growth, stimulation of rRNA synthesis by c-Myc is a key pathway driving cell growth and tumorigenesis, Stimulation of islet expression by 30 mmol/l glucose results from activation of a distinct, probably oxidative-stress-dependent signalling pathway., c-Myc has a pivotal function in the development of breast cancer; data show that decreasing the c-Myc protein level in MCF-7 cells by RNAi could significantly inhibit tumor growth both in vitro and in vivo, c-MYC amplification is an early event in breast cancer progression, while ZNF217 and Her2/neu amplification may play a role in the later stage of tumor development, expression of ESRA, bcl-2 and c-myc gene expression in fibroadenomas and adjacent normal breast is related to nodule size, hormonal and reproductive features, observed, subsequent to knocking down CRD-BP/IMP1, decreased c-myc expression, increased IGF-II mRNA levels, and reduced cell proliferation rates, p16(INK4A) reconstitution in p16(INK4A)-deficient T-ALL cells induced cell cycle arrest in the presence of cyclin E and c-Myc expression, uncoupled growth from cell cycle progression and caused a sequential process of growth, differentiation and apoptosis, Data show a coordinating inhibition of the proliferation of MCF-7 by enhancing expression of p53,p21 and decreasing expression of c-myc, elevated levels of Myc counteract p53 activity in human tumor cells.This mechanism could contribute to explain the c-Myc deregulation frequently found in cancer, chromatin remodeling at the c-myc gene involves the local exchange of histone H2A.Z, the c-MYC gene is sufficient to induce carcinogenesis for prostate cancer, c-Myc activates expression of a cluster of six miRNAs on human chromosome 13, results are consistent with the possibility that IL-5 inhibits apoptosis in JYTF-1 cells via the upregulation of c-myc expression, The presence of activated beta-catenin and c-myc in the epidermis of chronic wounds may serve as a molecular marker of impaired healing, conclude that alterations of the CMYC gene, including copy number gains and amplifications, are linked to genetically unstable bladder cancers that are characterized by a high histologic grade and/or invasive growth, A pivotal role for Myc in regulating mitochondrial biogenesis was shown., tumor-specific isoforms of Bin1 are precluded from interaction with c-Myc through an intramolecular polyproline-SH3 domain interaction. Furthermore, c-Myc/Bin1 interaction can be inhibited by phosphorylation of c-Myc at Ser62., c-Myc overexpression showed an upregulation of beta4 promoter activity, Kinetic analysis of the interconversion between the duplex and the quadruplex forms of the human c-myc promoter., mutant MYC proteins, by selectively disabling a p53-independent pathway, enable tumour cells to evade p53 action during lymphomagenesis, p53 represses c-myc transcription through a mechanism that involves histone deacetylation, 17-beta-estradiol promotes survival signals in breast cancer cells through mammalian target of rapamycin-dependent increase in Myc expression, MYC family genes might affect oncogenesis through distinct sets of targets, in particular implicating the importance of transcriptional repression, p300 can acetylate DNA-bound Myc, The MYC protein phosphorylation and turnover are thus linked to cell cycle exit in primary mouse CGNP cultures and the developing cerebellum., replicative senescence-specific factors may block c-Myc inhibition of Miz-1 activation of hMad4 expression, and the continual presence of hMad4 protein may transcriptionally repress selected c-Myc target genes, Increased wild-type MYC expression occurs frequently in human cancers, except in Burkitt's lymphoma., c-MYC binds to the genomic MTA1 locus and recruits transcriptional coactivators, which is essential for the transformation potential of c-MYC., transcription activity is repressed by various MM-1 isoforms, expression of cyclin D1 and c-Myc in epithelial ovarian cancer reaffirms the notion that they are crucial components in the pathway of tumorigenesis, data demonstrate that the sphingosine-recycling pathway for the generation of endogenous long-chain ceramide in response to exogenous C6-cer is regulated by ROS, and plays an important biological role in controlling c-Myc function, Myc induces nuclear encoded mitochondrial gene expression and mitochondrial biogenesis, thereby directly linking Myc's transcriptional properties to mitochondrial ROS production, promotion of genomic oxidative damage, and genomic instability., These results identify glycogen synthase kinase 3beta and FBW7 as potential cancer therapeutic targets and MYC as a critical substrate in the GSK3beta survival-signaling pathway., c-Myc isoforms differentially regulate cell growth and apoptosis in a species-specific manner, Site-specific ubiquitination regulates the switch between an activating and a repressive state of the Myc protein, and they suggest a strategy to interfere with Myc function in vivo., dual roles for p300-CBP-associated factor in Myc regulation, decreased internal ribosome entry site (IRES)-dependent Myc mRNA translation accounts for the phenotypic changes induced by inhibition of the BCR/ABL-ERK-dependent HNRPK translation-regulatory function., C-myc expression shows a positive association with increasing grade of breast carcinoma., We aimed to investigate the expression pattern of p53, Bcl-2 and C-Myc in colorectal cancer(CRC)tissues obtained from Egyptian colorectal cancer patients divided in two different groups, associated with and without Schistosoma mansoni., up-regulation of mitochondrial CLIC4, together with a reduction in Bcl-2 and Bcl-xL, sensitizes Myc-expressing cells to the proapoptotic action of Bax., Down-regulation of MYC is not necessary to abolish malignant phenotypes by induction of terminal monocyte-macrophage differentiation in leukaemic cells carrying t(9;11)(p22;q23)., Miz-1 is essential for Myc-mediated apoptosis, interferon-gamma, which induces HLA-DR antigens on the cell surface, also suppresses c-myc expression in situ, and is a possible non-immunological mechanism involved in the better long-term survival of colorectal cancer patients, Data show that hepatitis B virus X protein blocks the ubiquitination of c-myc through a direct interaction with the F box region of Skp2 and destabilization of the SCF(Skp2) complex., dominant-negative forms of c-Myc block transformation by activated Notch1, E6 and E7, suggesting that c-Myc is required for HPV16-mediated transformation, study shows that p14ARF directly associates with Myc and relocates Myc from the nucleoplasm to the nucleolus, in addition, p14ARF down regulates Myc activated transcription, overexpression of c-myc protects melanoma cells from IFN-beta-mediated growth inhibition, PEG10 is a direct target of c-MYC; findings link cancer genetics and epigenetics by showing that a classic proto-oncogene, MYC, acts directly upstream of a proliferation-positive imprinted gene, PEG10, c-myc seems to play a causal role in inducing anaplasia in medulloblastoma; it is proposed that c-myc dysregulation is involved in the progression of these malignant embryonal neoplasms, Myc overexpression causes DNA damage in vivo and the ATM-dependent response to this damage is critical for p53 activation, apoptosis, and the suppression of tumor development, Modifications in iron metabolism, resulting from the strong basal expression of c-Myc, and amplified by iron addition, could lead to a disruption in homeostasis and consequently to growth arrest in Burkitt's lymphoma., abnormal expression of REST/NRSF and MYC in undifferentiated neural stem/progenitor cells causes cerebellum-specific tumors. Furthermore, these results suggest that such a mechanism plays a role in the formation of human medulloblastoma., Positive C-MYC staining is detected mainly in the cytoplasm of esophageal cancer cells., Inhibition of hTERT expression by RNAi could increase the expression of C-myc protein in Hep-2 cells., These findings provide a molecular basis for increased TFRC1 expression in human tumors, illuminate the role of TFRC1 in the c-Myc target gene network, p16(INK4a) expression was regulated by the Polycomb group repressor Bmi-1, which is shown as a direct transcriptional target of c-Myc., Doubling the hMYC level by breeding homozygous transgenic animals switched the phenotype from primarily monocytic tumors to exclusively T-cell tumors. Results imply that MYC level affects the spontaneous acquisition of synergistic oncogenic mutations., In both Richter's transformation and prolymphocytic transformation, high-levels of AID mRNA expression and high-frequency mutations of c-MYC genes were detected., there is an alternative mechanism for the hypoxic induction of VEGF in colon cancer that does not depend upon HIF-1alpha but instead requires the activation of PI3K/Rho/ROCK and c-Myc, Results showed that certain regulation involved in c-myc, c-fos, and c-jun was present in the apoptosis, and the c-Myc dependent-on and Jun N-terminal kinase (JNK) pathway also play roles., Bcl2, in addition to its survival function, may also suppress DNA repair in a novel mechanism involving c-Myc and APE1, which may lead to an accumulation of DNA damage in living cells, genetic instability, and tumorigenesis, Taken together, these findings suggest that Bax and caspase activation, together with PKCdelta signaling are involved in c-Myc-dependent etoposide-induced apoptosis., Myc and E2F1 engage the ATM signaling pathway to activate p53 and induce apoptosis [review], These data suggest that an increase in c-Myc phosphorylation in response to prolonged ERK phosphorylation negatively auto-regulates c-Myc gene expression, leading to the suppression of its target gene expression and cell cycle block., Results describe the roles of the FarUpStream Element (FUSE), FUSE Binding Protein (FBP), FBP Interacting Repressor (FIR), and TFIIH in the regulation of c-myc expression., APL-like case lacking t(15;17) and the retinoic acid receptor alpha (RARA) breakpoint and also has the deletion MYC of 8q24 associated with the occurrence of MYC amplification on double-minute chromosomes (dmin)., Results show that the CT-element is not especially susceptible to the formation of breakpoints leading to chromosomal translocations in Burkitt's lymphoma., MYC activation, triggered by the insertion of human papillomavirus DNA sequences, can be an important genetic event in cervical oncogenesis., in diffuse large B-cell lymphoma, molecular alterations in ice, bcl-2, c-myc and p53 are present in hematopoietic cells from bone marrow as well as in primitive hematopoietic progenitors, p21Cip1 is one of the direct mediators of induced c-Myc following increased polyamines and that p21Cip1 repression by c-Myc is implicated in stimulation of normal intestinal epithelial cell proliferation, This study provides the first evidence for regulation of global chromatin structure by an oncoprotein and may explain the broad effects of Myc on cell behavior and tumorigenesis., TGFbeta suppresses TERT by Smad3 interactions with c-Myc and the hTERT gene, c-Myc is only required for pre-TCR-induced proliferation but is dispensable for developmental progression from the DN to the DP stage, Having an S allele in the L-myc gene may increase the risk of renal failure., proteins implicated in replication initiation are selectively and differentially bound across the c-myc replicator, dependent on discrete structural elements in DNA or chromatin, Ras and c-Myc play important roles in the up-regulation of nucleophosmin/B23 during proliferation of cells associated with a high degree of malignancy, thus outlining a signaling cascade involving these factors in the cancer cells., Together, these results demonstrate that ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway is an important mechanism of oncogenic c-myc activation in pancreatic cancer., Ketogenesis is an undesirable metabolic characteristic of the proliferating cell, which is down-regulated through c-Myc-mediated repression of the key metabolic gene HMGCS2., Functional promoter analyses revealed that both the Myc-binding site cluster and the C/EBPalpha-binding site are essential for strong transcriptional activation, and that Myc and C/EBPalpha synergistically activate the WS5 promoter, c-myc and VEGFA may be involved in the regulation of angiogenesis in esophageal adenocarcinoma, provide a mechanism for elevated Myc expression in hormone-dependent and hormone-independent breast cancer, Epstein-Barr virus (EBV) acts as an antiapoptotic in Burkitt lymphoma (BL) by selecting among three transcriptional programs, all of which, unlike the full virus growth-transforming program, remain compatible with high c-myc expression., Several genes in the MYCN amplicon, including the DEAD box polypeptide 1 (DDX1) gene, and neuroblastoma-amplified gene (NAG gene), have been found to be frequently co-amplified with MYCN in NB., Nuclear arrangement of c-myc genes and transcripts was conserved during cell differentiation and, therefore, independent of the level of differentiation-specific c-myc gene expression., NDRG2 expression is repressed by Myc via Miz-1-dependent interaction with the NDRG2 core promoter, Fluorescent protocol can successfully be applied to diagnostic needle biopsies to identify relative 8q gain in prostate carcinomas and that patients with a MYC/CEP18 ratio > or = 1.5 present a significantly higher risk of dying from the disease., repression of BCL2 transcription is the single essential consequence of targeting the MIZ-1 pathway during apoptosis induction, which explains a copperative interaction between c-MYC and BCL2, Max as a novel co-activator of C/EBPalpha functions, thereby suggesting a possible link between C/EBPalpha and Myc-Max-Mad network., Results provide a snapshot of genome-wide, unbiased characterization of direct Myc binding targets in a model of human B lymphoid tumor using ChIP coupled with pair-end ditag sequencing analysis (ChIP-PET)., identify c-MYC as an essential mediator of NOTCH1 signaling and integrate NOTCH1 activation with oncogenic signaling pathways upstream of c-MYC, FOXM1c transactivates the human c-myc P1 and P2 promoters synergistically with Sp1, a transcription factor known to bind and transactivate these two promoters, The c-Myc oncogene expression was very low in normal and cancer tissues but highly increased in papillomatosis., E-cadherin repression is necessary for c-Myc-induced cell transformation., establish PML-mediated destabilization of Myc and the derepression of cell cycle inhibitor genes as an important regulatory mechanism that allows cell differentiation, Our data suggest that Mel-18 regulates Bmi-1 expression during senescence via down-regulation of c-Myc., MYC amplification is not associated with "basal-like" phenotype and proved to be an independent prognostic factor for breast cancer patients treated with anthracycline-based chemotherapy., c-MYC functions are cellular-context-dependent and selectively regulated genes are responsible for its differential properties., indicate a role for c-myc in the transcriptional regulation of survivin in breast cancer, The expression of hTERT was associated significantly with that of c-myc in laryngeal squamous cell carcinoma., Genes with both c-Myc-and sp1-binding sites have a distinct expression signature when compared to genes with either site alone., c-Myc-dependent priming of the mitochondrial pathway is critical for the capacity of TRAIL-induced caspase-8 signals to activate effector caspases and for the establishment of lethal caspase feedback amplification loop in human cells., oncogenic deregulation of c-MYC prevents repair of replication-stress induced DNA lesions in G(2)-phase; suggests c-MYC-mediated persistence of DNA lesions during mitosis leads to chromosomal missegregation & underlies c-MYC-induced chromosome instability, The KSHV latency-associated nuclear antigen is responsible for c-myc deregulation by inihibiting glycogen synthase kinase-3beta-mediated phosphorylation of c-Myc threonine 58., The effect of gamma-secretase inhibitor on the mTOR pathway was rescued by expression of c-Myc, a direct transcriptional target of Notch, implicating c-Myc as an intermediary between Notch and mTOR, Subcellular localization of c-Myc and P-c-Myc is not crucial in determining the mode of cell death in prostate carcinoma cell lines., Notch1 mediates T cell and epithelial cell transformation at least in part by sustaining c-Myc levels., Myc is the most frequently deregulated oncogene in human tumors. Myc function relies on overcoming transcriptional repression by Mnt. Relief of Mnt-mediated repression is more important for target gene regulation than the sole activation by Myc. Review., c-MYC down-regulates the NF-kappaB & interferon pathway in a dose-dependent fashion, acting at at least 2 levels, propose that the non-incidental coamplification of Myc and either ERBB2 or EGFR occurred through translocation and subsequent rearrangement, observations raise the possibility that unscheduled replication origin activation at inserted HPV-18 viral DNA sequences triggers DNA amplification in this cancer cell line and the subsequent overexpression of the MYC oncogene, VPA downregulated c-Myc expression at transcriptional levels., These results provide evidence of direct regulation of Mxi1 by FOXO3a and imply an additional mechanism through which the PI3-kinase/Akt/FOXO pathway can modulate Myc function., inhibition of beta-catenin and in effect c-myc expression through activation of PPARgamma may help prostate cancer cells to restore several characteristics of normal prostate cells phenotype, This study demonstrates that the two consensus Lef/Tcf binding elements (TBE)reported in neoplastic cells are dispensable for c-Myc regulation in normal keratinocytes, which instead use a novel TBE sequence variant., repression of c-myc modulates HIF-1 inhibition of mitochondrial biogenesis and cellular respiration, DKK1 and SFRP1 inhibit the transformed phenotype of breast cancer cell lines, and DKK1 inhibits tumor formation., Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation., Data indicate that PVT-1 expression is restricted to a low number of normal tissues compared to c-Myc mRNA, whereas the gene is highly expressed in many transformed cell types including neuroblastoma cells that do not express c-Myc., Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS., there was a highly significant correlation between breakpoints 5' of MYC cluster 1 and fusions to IGH switch gamma region and breakpoints downstream of MYC cluster 2 and fusions to IGH switch alpha region in spoadic Burkitt's lymphoma, High expression levels of USP28 are found in colon and breast carcinomas, and stabilization of MYC by USP28 is essential for tumour-cell proliferation., c-myc gene expression may be regulated by intranuclear localization of its RNA, While cMyc-Asp11Ser can be considered a putatively functional polymorphism located in the N-terminal domain, it is not associated with breast cancer risk, tumor characteristics or survival., Rac1 activates proliferation of normal fibroblasts through stimulation of c-myc phosphorylation without affecting ERK1/2 activity, C-myc gene had the same location chromosome 8 in pluripotent and in differentiated human embryonic stem cells, Amplification of the c-myc proto-oncogene occurs in hepatocellular carcinoma(HCC) and colorectal adenocarcinoma(MCA); its detection may have a useful diagnostic significance in differentiating intrahepatic cholangiocarcinoma(ICC)from MCA or HCC from ICC., findings identify a critical function of c-Myc in DNA replication and suggest a novel mechanism for its normal and oncogenic functions, These results identify L11 as a feedback inhibitor of c-Myc and suggest a novel role for L11 in regulating c-Myc-enhanced ribosomal biogenesis., Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells., interphase Fish on samples from 30 MCL patients revealed 8 numerical c-myc-aberrations and 6 delp16, RbAp48-mediated transformation of HPV16 is probably because of the regulation by RbAp48 of tumor suppressors retinoblastoma and p53, apoptosis-related enzymes caspase-3 and caspase-8, E6, E7, cyclin D1 (CCND1), and c-MYC., atorvastatin, by inhibiting HMGcoA reductase, induces changes in phosphoprotein signaling that in turn prevent MYC-induced lymphomagenesis, Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen stabilizes c-Myc., Results establish a new function for PIM1 as a MYC cofactor that phosphorylates the chromatin at MYC-target loci and suggest that nucleosome phosphorylation, at E boxes, contributes to MYC-dependent transcriptional activation and cellular transformation., Both MYC amplification and TERT expression appear to be associated with high genomic instability and proliferation., Myc, Sp1, and HDAC1 coexist in the same DNA-protein complex at the HIV promoter. Short hairpin RNA inhibition of c-Myc reduces both c-Myc and HDAC1 occupancy, blocks c-Myc repression of Tat activation, and increases LTR expression., the tumorigenic growth effects of MYC in TGFalpha-expressing liver progenitor cells are not solely dependent on its apoptotic activity., Erf provides a direct link between the RAS/ERK signaling and the transcriptional regulation of c-Myc and suggests that RAS/ERK attenuation actively regulates cell fate, levels of c-myc expression were up-regulated and those of p53 expression were down-regulated by HCV F protein., A truncated form of N-Myc wild type can fully rescue the proliferation defect in myc-null fibroblasts, but rescue is dependent on the highly conserved Myc homology box II., blockage of terminal differentiation upon arsenic trioxide treatment may be mediated through c-Myc., This review proposes that a positive feedback loop of c-myc and Wnt signaling operates in breast cancer., These findings indicate that vIRF-3 can effectively stimulate c-Myc function in primary effusion lymphoma cells and consequently contribute to de-regulation of B-cell growth and differentiation., These results suggest that c-Myc may be involved in the regulation of telomere length through its direct binding with TRF1/PIN2., Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization., Review describes a microRNA cluster induced by oncogenic transcription factor c-myc that is implicated in inhibiting proliferation, as well as inhibiting apoptosis and promoting angiogenesis., HIF-1 cooperates with dysregulated c-Myc to promote glycolysis by induction of hexokinase 2 and pyruvate dehydrogenase kinase 1., Various nucleotide substitutions in the wild-type sequence from the c-MYC nuclease-sensitive element were ranked for their effects on transcription, the results implicated the triplex structure in the transcription arrest., These data indicate that DKC1 is a direct and conserved transcriptional target of c-MYC, and suggest a biologic basis for DKC1 overexpression in neoplasia., Usp28 dissociates from Fbw7alpha in response to UV irradiation, providing a mechanism how Fbw7-mediated degradation of Myc is enhanced upon DNA damage., Blimp-1 could directly repress the expression of c-myc in 2ME2-mediated differentiation induction of multiple myeloma cells., ZO-2 down-regulates cyclin D1 transcription by interacting with the c-Myc/E box element and by recruiting histone deacetylase 1, c-Myc activates DR4 transcription through E-box DNA-response elements located in the DR4 promoter, thereby increasing the expression of cell-surface pro-apoptotic death receptors in TRAIL-resistant cell lines, Results suggest a general model by which a proliferation factor (c-Myc) and a differentiation factor (HNF4alpha1) may compete for control of genes involved in cell proliferation and differentiation., MYC and PVT1 contribute independently to ovarian and breast pathogenesis when overexpressed because of genomic abnormalities, Myc down-regulation is a mechanism to activate the Rb pathway in STAT5A-induced senescence, c-Myc oncoprotein deregulation is associated with overall genomic instability and its levels were a measure of progression in premalignant cervical lesion., The positive rate of C-myc was significantly higher in colorectal carcinoma, colorectal adenoma with malignancy, and colorectal adenoma than in normal colorectal mucosa., Thus the c-myc P2E behaves as a dual-purpose STAT3 element with anomalous characteristics in HepG2 cells., synergistic effect of MYC and BCL6 mutations could explain the survival and clonal selection of a t(3;8) carrying cell in lymphoma progression, The PKB-dependent mechanism of insulin-stimulated c-Myc expression in HT29 cells was shown to involve the activation of mTOR in c-Myc translation, Diffuse large B-cell lymphomas (DLBCL) with concurrent t(14;18) and 8q24/c-MYC rearrangement is a subgroup of germinal center-DLBCLwith poor outcome, BP1 may regulate bcl-2 and c-myc expression, Expression of Ets-2, SRC-1 and c-Myc individually are all associated with reduced disease-free survival in breast cancer, cooperative role for c-Met and c-Myc in large-cell anaplastic medulloblastoma formation, results indicate that cyclin X is a novel member of the human cyclin family and positive regulator of c-Myc-mediated gene transcription, Through the analysis of human and mouse models of B cell lymphoma, study shows here that Myc regulates a much broader set of miRNAs than previously anticipated., Functional link between MYC and hTERT seems to be impaired depending on the molecular essential thrombocytthemia subtype., Id2 commonly is overexpressed in highly proliferative T-cell lymphomas, and its expression may result from transcriptional activation of myc in these tumors., The c-myc translocation is likely crucial to the pathogenesis of the peripheral B-cell lymphoblastic lymphoma., Using ectopic expression of Oct4, Sox2, Klf4 and Myc, we have derived iPS cells from fetal, neonatal and adult human primary cells, variation at putative 8q24 cis-regulator(s) of transcription can significantly alter germline c-MYC expression levels and, thus, contribute to prostate cancer susceptibility by down-regulating the prostate tumor suppressor KLF6 gene., These data suggest that TLR3 contributes to the malignant phenotype leading to invasive carcinoma in head and neck squamous cell carcinoma., The established renal cell carcinoma consist of two cell populations, one containing four and one containing five copies of the MYC oncogene., Downregulation of c-Myc is critical for 2ME2-induced oxidative stress and apoptosis in AML cells., expression of the Myc and Pim proto-oncogenes by Jak2V617F was found to be FERM domain dependent., bortezomib down-regulation of PRDM1beta preceded decreased IRF4 and c-MYC expression, Results describe the interrelationship between H pylori and Epstein-Barr virus infection in gastric carcinogenesis, focusing on p53 mutation and c-Myc, Bcl-2 and Bax expression., By misdirecting the activity of Activation-Induced Deaminase (AID) to a conditional MYC transgene, sporadic, AID-dependent MYC activation in germinal center B cells of Vk*MYC mice, is achieved., Data demonstrate that c-myc can block myeloid cell differentiation independent of the apoptotic response., Epstein-Barr virus EBNA3C residues 130 to 190, previously shown to bind to the SCFSkp2 complex, also can strongly associate with the c-Myc oncoprotein., MYC alteration is observed in the beginning of gastric carcinogenesis and could be used as a therapeutic target., MYC can stimulate epidermal stem cells to differentiate [perspective], three cases of FL are described in which both t(14;18) and a C-MYC translocation were identified at presentation, that may identify a particularly aggressive subtype of FL, Overexpression of Myc stimulated sebocyte differentiation, whereas overexpression of beta-catenin stimulated involucrin and cornifin expression., c-Myc inhibited Ras-mediated differentiation by a mechanism that involves the blockade of c-Jun induction in response to Ras signal., C-myc RNA signals were positioned in the most internal parts of the cell nuclei preferentially associated with the nucleoli., Damaging exercise induced the expression of capZalpha, MCIP1, CARP1, DNAJB2, c-myc, and junD, each of which are likely involved in skeletal muscle growth, remodeling, and stress management., ). Nicotinamide and nicotinamide N-oxide drastically decreased c-myc expression, but isonicotinic acid had no effect, suggesting that these compounds differentiate HL-60 to granulocytes through different pathways, Myc is required to allow the interaction of the E2F1 protein with the E2F gene promoters., Results suggest that Bin1 gene suppression caused by oncogenic E1A via Rb/E2F1 inactivation is an essential step in cell cycle progression promoted by c-Myc, and subsequently, E1A transformation., variations in c-myc and p21(WAF1) expression delay apoptosis making PBL resistant to sodium butyrate for several hours, The (rs13254738) variant of 8q24 has a protective effect for breast cancer., Pyk2/ERK 1/2 mediate Sp1- and c-Myc-dependent induction of telomerase activity by epidermal growth factor, c-MYC plays a role in the early tumorigenesis of astrocytomas., Although knockdown of c-Myc or caspase-2 does not affect Bax expression, caspase-2 is important for cytosolic Bax to integrate into the outer mitochondrial membrane, and c-Myc is critical for oligomerization of Bax once integrated into the membrane, MYC rearrangements are associated with both hyperdiploid and nonhyperdiploid myeloma tumors., EBV is not related to the overexpression of Bcl-2 and c-Myc (nuclear) in gastric carcinomas., The inhibition of FOXO3a-mediated activation of the p27 gene by the high aberrant expression of c-Myc in many tumor cells likely contributes to their uncontrolled proliferation and invasive phenotype., MM-1, a c-Myc interacting protein, interacts with HCV ARFP/F protein, which can result in the enhancement of the c-Myc activity., Cdk5 activation in cells that overexpress cyclin G1 leads to c-Myc phosphorylation on Ser-62, which is responsible for cyclin G1-mediated transcriptional activation of cyclin B1., These findings establish that Myc, via p400, is an essential downstream target of adenovirus E1A., The c-fos and c-myc expression was remarkably downregulated in nasal polyps from topical steroid treated patients compared to untreated patients., the downregulation of c-Myc mediated by silencing DNA-PKcs, we found a substantial number of primary diffuse large B-cell lymphomas (DLBCLs) of bone cases with a rearrangement of BCL2 and c -MYC, hBD-1 expression is mediated by c-Myc and the CLOCK, This study provides a direct link between the growth factor signaling pathways regulated by PI3 kinase/Akt and MAP kinases with Myc-mediated transcription., These results suggest a heterogeneous immunophenotype and genotype for c-myc/Ig DLBCL, with CD10(-)/BCL6(+)/MUM1(-) cases the most frequent., There was a significant association between an intronic SNP in c-myc and prostate cancer., These results indicate that the activated Notch1 receptor and alpha-enolase or MBP-1 cooperate in controlling c-myc expression through binding the YY1 response element of the c-myc promoter to regulate tumorigenesis., Continued expression of c-Myc is necessary for maintenance of the growth state in cells expressing FRAT1, implying that c-Myc may be a critical element in oncogenesis induced by FRAT1., MYC inactivation induced global permanent changes in gene expression detected by microarray analysis in murine tumor models and human lymphomas., C-terminal region of p300 provides corepressor function and facilitates the recruitment of p300 and HDAC3 to the YY1-binding site and represses the c-Myc promoter., c-Myc regulates calpain activity through calpastatin; apoptosis induced by calpain inhibition is dependent on c-Myc, and calpastatin knockdown promotes transformation in c-Myc-negative cells, Study shows that the poly(A) tail enhances 48S complex assembly by the c-myc internal ribosome entry sequences., Gains (3-4 copies) of 8q24 (c-myc) were found in the low frequencies in nondysplastic Barrett's esophagus. Frequency increased with stage of dysplasia and reached a high incidence in esophageal adenocarcinoma., hnRNP A1 has a role in mediating rapamycin-induced alterations of cyclin D1 and c-myc IRES activity in an Akt-dependent manner and provide the first direct link between Akt and the regulation of IRES activity, Upregulation of nuclear MYC protein expression is a highly prevalent and early change in prostate cancer; increased nuclear MYC may be a critical oncogenic event driving human prostate cancer initiation and progression., hTERT gene expression is maintained by a mechanism involving Ets2 interactions with the c-Myc transcription factor and the hTERT gene promoter, a protein-DNA complex critical for hTERT gene expression and breast cancer cell proliferation., MYC, LDHB, and CCNB1 may have roles in progression of medulloblastoma, Elevated c-myc expression in GFs by thrombin was noted after 2 hours of exposure. Moreover, the stimulation of c-myc mRNA expression by thrombin can be attenuated by D-Phe-Pro-ArgCH(2)Cl, a serine-proteinase inhibitor., rapamycin limited expression of c-MYC by inhibiting c-Myc mRNA translation, endothelin-1, via Src/PI-3K signaling, augments c-myc expression leading to enhanced androgen receptor expression in prostate cancer, Coamplification of HER2 and MYC occurs in a subset of patients with metastatic UCC, analysis of the induction of nucleotide metabolic genes by c-Myc in multiple system, a circuit involving c-myc, miR-17-92, and HIF-1 alpha may play a role in cancer cell proliferation under normoxia in a cellular context-dependent manner, enhancement of alpha-TS-induced apoptosis by ATRA in leukemic cells was through up regulation of Bax and lipid peroxidation, and down regulation of c-myc and GSH., MYC translocations are associated with multiple myeloma, A novel functional link between C-MYC and dNTP metabolism and identify its role in proliferation of tumor cells., one of the major functions of C-MYC overexpression in melanoma progression is to continuous suppress BRAF(V600E)- or NRAS(Q61R)-dependent senescence programs, MYC stimulates EZH2 expression by repression of its negative regulator miR-26a, Since expression of c-Myc in antiestrogen-arrested cells can recapitulate many of the effects related to cell cycle progression, the estrogen-regulated genes that are targets of c-Myc are identified using cells inducibly expressing c-Myc in breast cancer., E2F1 may function as a critical antiapoptotic factor both in human and in rodent liver cancer through its ability to counteract c-Myc-driven apoptosis via activation of PIK3CA/Akt/mTOR and c-Myb/COX-2 pathways, Overexpression of c-myc is associated with prostate cancer., Translocation is more common in germinal centre-like B (GCB) cell type of adult diffuse large B-cell lymphoma than in non-GCB type, and associated with advanced disease., the presence of a MYC gene rearrangement was the strongest statistically independent predictor of OS (relative risk 3.4, P=0.004) and EFS (relative risk 2.5, P=0.015), ectopic expression of C/EBPepsilon, as well as C/EBPalpha, can induce the monocytic differentiation of myelomonocytic leukemic cells with MLL-fusion gene through the downregulation of Myc, show that differential overexpression of Myc transcriptional targets and low expression of genes involved in sympathetic neuronal differentiation predicts relapse and death from disease, integration of mtDNA into the nuclei of cervical epithelium cells may be involved in the carcinogenesis of cervical epithelium cells and the expression of c-myc might be related to the integration of mtDNA sequence into nuclei of cervical epithelium cell, c-Myc expression may be useful in predicting tumor recurrence in patients with low-grade meningiomas, The role of the MYC protooncogene in clear cell renal cell carcinoma., MYCN may limit cell adhesion to the extracellular matrix and promote cell migration by downregulating integrin alpha1, Immunohistochemistry using antibodies to determine the protein expression of Fas, Fas-L, Bax, Bcl-2, p53 and c-Myc in skin of venous ulcer patients., mrtl may serve an important function in regulating Myc translation and localization to the nucleus, perhaps ultimately contributing to the role of the c-myc locus in oncogenesis., c-MYC directly regulates the expression of AP4 via CACGTG motifs in the first intron of the AP4 gene., requirement for Myc in the induction of the hTERT promoter by E6 and suggested that occupancy of the promoter by Myc determines the responsiveness of E6 and the downstream induction of telomerase and cell immortalization., Data show that activation of Myc inhibited p27-mediated erythroid differentiation without affecting p27-mediated proliferation arrest., Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas, 18852287:Results indicate that association of c-Jun, TCF$, and beta-catenin with a downstream enhancer element provides the principal regulation of c-Myc expression., In the present review, we focus on the deregulation of the MYC oncogene in gastric adenocarcinoma carcinogenesis, including its association with Helicobacter pylori (H pylori) and clinical applications [review], EB1 is controlled by c-Myc, RhoA, and CDC42, which have all been linked to hepatocellular carcinoma (HCC) malignancy., The ability of Cdx1 and c-myc to initiate the earliest stages of transdifferentiation of esophageal keratinocytes toward a cell fate characteristic of Barrett's esophagus., Myc recruits the Tip60/p400 complex to achieve a coordinated histone acetylation/exchange reaction at activated promoters., The overexpression of c-Myc during NK-cell development promotes transcription from the distal promoter element and contributes to the overall transcription of multiple KIR genes., Results suggest that THAP11 functions as a cell growth suppressor by negatively regulating the expression of c-Myc., the domains of GpIbalpha mediating c-Myc-like functions are modular, genetically distinct, and independent of those involved in vWFR signaling., c-Myc has a role in regulating proliferation and survival of glioma cancer stem cells, Expression of the TAF4b gene is induced by MYC through a non-canonical, but not canonical, E-box which contributes to its specific response to MYC., These results indicate that c-MYC may promote transformation through the induction of HSP60 expression., c-Myc activity is required for growth and maturation of the exocrine pancreas., deregulation of c-MYC in lymphoma cells does not overcome the tumor suppressor function of TGF-beta and that repression of E2F-1 transcription is sufficient for the efficient induction of cytostasis., a mechanistic link between JNK activity and liver cell proliferation via p21 and c-Myc and suggest JNK1 targeting can be considered as a new therapeutic approach for HCC treatment., 8q24/c-MYC translocation is associated with diffuse large B-cell lymphoma., HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma, analysis of Wnt/beta-catenin and Myc signaling in liver cancer, Over-expression of the Tp53, CCND1, and C-myc genes appears to play a role in development of human cancer by regulating the expression of mRNA., The switch from Mnt-Max to Myc-Max during bile duct ligation (cholestasis) and in hepatocytes treated with lithocholic acid is responsible for the induction in p53 and cyclin D1 expression and contributes to apoptosis., study found that FBP1 as well as FBP3 are more frequently expressed in prostate and bladder cancer than in renal cancer; in addition, a positive correlation between levels of FBP1, FBP3 and c-Myc was exclusively detectable in renal cell carcinomas, c-Myc negatively regulates the expression of BRD7., a combinatorial regulatory program in which MYC cobinds to virtually all NOTCH1-bound promoters, The group of patients with > 5-fold myc amplicon CN showed significantly shorter survival than those with < 5-fold CN (p = 0.045), independent of histological subtype., Functional studies indicate that EMYCS has transcriptional transactivation capacity and suggest that it is required to activate the C-MYC promoter during exit from quiescence., the regulation of c-Myc by Axin1 is impaired in several tested cancer cell lines with known stabilization of c-Myc or loss of Axin1., Down-regulation of c-MYC resulted in inhibition of cellular proliferation, clonogenic growth and cell cycle progression., Myc down-regulation in astrocytoma cells led to G1 accumulation and an inhibition of cell proliferation characterized by S phase delay, LPA stimulates hypoxia-inducible factor-1-independent VEGF expression to promote tumor angiogenesis through activation of the c-Myc and Sp-1 transcription factors, 1,25(OH)(2)D(3) reduces both c-Myc mRNA levels and c-Myc protein stability to inhibit growth of prostate cancer cells., IFI16 and NM23/NDPK are simultaneously bound in vivo to the promoters of the oncogene cMYC and of P53, Mechanisms of WIF1-induced G(1) arrest include (a) SKP2 down-regulation leading to p27/Kip1 accumulation and (b) c-myc down-regulation releasing p21/WAF1 transcription., Polyamines regulate E-cadherin transcription through c-Myc modulating intestinal epithelial barrier function., IL-5 induces cell proliferation and anti-apoptosis through the JAK/c-Myc pathway, and JAK1 and JAK2 activation participate in IL-5-induced up-regulation of c-Myc., miR-145 provides a direct link between p53 and c-Myc in this gene regulatory network, MYC and EIF3H are frequently coamplified in NSCLC and that a high copy number correlates with increased epidermal growth factor receptor tyrosine kinase inhibitors sensitivity., highlight an important role for Lin-28B in Myc-driven cellular phenotypes, c-Myc transcriptionally represses miR-23a and miR-23b, resulting in greater expression of their target protein, mitochondrial glutaminase, in human P-493 B lymphoma cells and PC3 prostate cancer cells, IL-6 can reverse the expression level of CD33 by up-regulating MYC followed by the down-regulation of CEBPA expression, Elevated activity of MYC and E2F is associated with the "basal" breast cancer subgroup., MYC transcription signature is strongly associated with the malignant conversion of preneoplastic liver lesions., Overexpression of the LKB1 gene inhibits lung carcinoma cell proliferation partly through degradation of c-myc protein., Data show that FGFR1 and DDHD2 at 8p12 cooperated functionally with MYC, whereas CCND1 and ZNF703 cooperated with a dominant negative form of TP53., The Bax activator BimEL increased rapidly, driving cells towards apoptosis likely controlled by c-Myc and p21(WAF1) activities., Study shows that genomic instability due to Myc amplification may cause specific amplification of EGFR and/or ERBB2 in gallbladder adenocarcinoma., These results point to an important role for p300 in maintaining genomic integrity by negatively regulating c-myc., Data show that the over-expression of hTERT, c-myc and Ki-67 may play a vital role in the progress of hepatocellular carcinoma developing., Alveolar macrophages stimulated with SiO(2) have the ability to induce c-myc oncogene expression in human embryo lung fibroblasts., Results identify a c-Myc-SIRT1 feedback loop in the regulation of c-Myc activity and cellular transformation, supporting/suggesting a role of SIRT1 in tumor suppression., c-myc siRNA can efficiently induce growth inhibition, decrease the expressions of c-myc mRNA and protein, and induce apoptosis in HL-60 cells., Exposures mimicking conditions of CO (2) pneumoperitoneum lead to significant overexpression of C-MYC and HMGB-1 in neuroblastoma cells with decreased apoptosis, Both OH-2 and primary cells have a complex secondary translocation in which the IGK 3' enhancer is inserted between MYC and MAFB, resulting in dysregulation of both oncogenes, A cooperative role for ERalpha and c-Myc in estrogen regulation of VEGF and the ability of c-Myc to partially mimic estrogen regulation of angiogenesis., The dermal vasculature of Myc-expressing embryos is characterized by a reduction in vessel branching, which occurs despite upregulation of the proangiogenic factors vascular endothelial growth factor-A and angiopoietin-2., MYC gene amplification detected 23.7% head/neck lesions with 14.2% dysplastic & 26% HNSCC samples. Clinicopathol relation between MYC gene amplification with clinical parameters found significant relation of MYC amplification with tumor progression., MYC rearrangement has a role in progression of smouldering myeloma to myeloma, A promoter-targeted siRNA inhibits transcription of the c-myc gene., CIP2A and MYC appear to be regulated in a positive feedback loop, wherein they promote each other's expression and gastric cancer cell proliferation., Cyclosporine A inhibits colorectal cancer proliferation probably by regulating expression levels of c-Myc, p21(WAF1/CIP1) and proliferating cell nuclear antigen., The MYC promoter is specifically activated by overexpression of DLX5., c-MYC amplification and polysomy 8 have limited predictive or prognostic value in suboptimally-resected, advanced stage EOC treated with platinum-based combination chemotherapy., BCL2 and MYC translocations have a role in dual-hit lymphoma/leukemia, A multivariate analysis of additional SNPs across the broader 8q24 region revealed three independent prostate cancer risk-associated SNPs, including rs16901979, rs13254738, and rs10086908., Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation., an additional mechanistic explanation for c-Myc-induced DNA damage and senescence, Data show that the DNA-binding activities of c-Myc to the hTERT promoter were decreased in butein-treated cells, and reatment with butein also suppressed the activation of Akt, thereby inhibiting hTERT phosphorylation and translocation into the nucleus., The alleles of rs6983267 differentially bind transcription factor 7-like 2 (TCF7L2) and the risk region physically interacts with the MYC proto-oncogene., Data indicate that cyclin E2-Cdk2 activation by estrogen occurs via E2F- and CHD8-mediated transcription of cyclin E2 downstream of cyclin D1, and does not require c-myc., findings collectively demonstrate that CTCF-binding at the human MYC locus does not repress transcriptional activity but is required for protection from DNA methylation, RNA-binding protein HuR reduced c-Myc expression by associating with the c-Myc 3' untranslated region (UTR) next to a miRNA let-7-binding site, C-myc could be another protooncogene in fibrous dysplasia., Nucleolin binding facilitates the formation and increases the stability of the c-myc G-quadruplex structure., the alpha6Bbeta4 integrin inhibits colon cancer cell proliferation and c-Myc activity and is significantly down-regulated in colon cancer cells relative to its alpha6Abeta4 counterpart, MYC cytoplasmic immunoreactivity can be the result of MYC insertion with the breakpoints within or close to the regions that are able to target the nucleus, Lymphomas with concurrent BCL2 and MYC translocations, have identified JAK2/PI3K-mediated and c-Myc-dependent transactivation of survivin as a novel pathway in the transcriptional network orchestrated by BCR/ABL, Detection of nuclear c-Myc in leiomyosarcoma predicts decreased overall and metastasis-free survival, independent of standard prognostic variables, tumor size, histological grade, and TNM stage., Increased expression of miR-17-92 cluster during colorectal adenoma to adenocarcinoma progression is associated to DNA copy number gain of miR17-92 locus on 13q31 and c-myc expression., MYC gains and amplifications are frequent cytogenetic abnormalities in squamous cell carcinomas (SCC) and may play a relevant role in promoting SCC undifferentiation and tumoral progression., These results suggest that KLF5 is not only essential for MYC transcription in proliferating epithelial cells but also mediates the inhibitory effect of TGFbeta on MYC transcription., the presence of the Core MYC Signature may predict clinical responsiveness to therapeutics that are designed to disrupt MYC-mediated phenotypes, During senescence, miR-34a targets the important proto-oncogene MYC and our data suggest that miR-34a thereby coordinately controls a set of cell cycle regulators, Ovol2 directly represses two critical downstream targets, c-Myc and Notch1, thereby suppressing keratinocyte transient proliferation and terminal differentiation, respectively, MYC gene rearrangements are associated with diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy., Cyclic strain activate the c-Myc promoter, leading to c-Myc transcription and downstream gene induction in human endothelial cells., MyD88 induces the differentiation and maturation of dendritic cells by suppressing c-myc activity and expression., miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements., TC-PTP as an important effector of the MYC-driven proliferation program in B-cell lymphomas, TGF-beta can override Myc activity despite a stabilizing cancer mutation and induce senescence in myeloid tumor cells, at least in part by induction of Mad1, HER2 phenotype upregulates hTERT through c-myc activation and confers radio-resistance to breast cancer cells., Epstein-Barr virus LMP2A bypasses p53 inactivation in a MYC model of lymphomagenesis., SKIP acts with c-Myc and Menin to promote HIV-1 Tat, Study identified an overrepresentation of focal amplifications of known (FGFR3, CCND1, MYC, MDM2) and novel candidate genes (MYBL2, YWHAB and SDC4) in stage Ta bladder carcinoma., The expression of pituitary tumor transforming gene mRNA was significantly correlated with the expression of c-myc gene in multiple myeloma., Data show that PLZF-RARalpha binds to a region of the c-MYC promoter, suggesting that PLZF-RARalpha may act as a dominant-negative version of PLZF by affecting the regulation of shared targets., c-MYC is a novel regulator of osteogenesis, gene expression and osteoblast differentiation induced by vitamin D., Overexpression of c-Myc leads to a centroblast phenotype, promotes high constitutive expression of the key GC factors Bcl-6, E2A and activation-induced cytidine deaminase and contributes to proliferation and somatic hypermutation., These findings suggest that some splicing forms of TCF7L2 may be functionally important for regulation of MYC expression in colon tissue but this regulation is not directly dependent on rs6983267., Serum promotes pancreatic cancer growth through induction of the proproliferative NFAT/c-Myc axis., C-myc amplification was highly correlated with young age, metastases and large cell histology in medulloblastoma., In table 4 , positive correlations were found between the expression levels of GST-pi and EGFR as well as Neu and C-myc (p 220322930 0.05), Data show that the AS E-box was bound by HIF-1alpha in all the three melanoma cell lines, and nder arginine depletion conditions, HIF-1alpha was replaced by c-Myc in A2058 and SK-MEL-2 cells but not in A375 cells., Data suggest that a distinct chromatin architecture coordinated by beta-catenin/TCF-bound Wnt responsive enhancers accompanies transcriptional activation of MYC gene expression., Data show that Myc repressed Ras-induced senescence, and that Cdk2 interacted with Myc at promoters, where it affected Myc-dependent regulation of genes, including those of proteins known to control senescence., Data show that small interfering RNA against JNK1, but not JNK2, exhibited similar effects to JNK inhibitors that reduced the protein levels of c-Myc and Bcl-2., Despite their identical morphology, secondary angiosarcomas (AS) are genetically different from primary AS and are characterized by a high frequency of high level amplifications of MYC., HBP1 binds c-Myc in cells, and expression of HBP1 inhibits c-Myc transactivational activity at least partly by preventing c-Myc binding to target gene promoters., human gliomas overexpress c-Myc, PTB, hnRNPA1 and hnRNPA2 in a manner that correlates with PKM2 expression, Data show a key role for ezrin as a mediator of c-Myc-induced tumorigenesis in prostate cancer cells., Young age (<4 years), presence of metastases at diagnosis, large cell histology, and c-myc chromosomal amplification are independently associated with negative outcome in medulloblastoma., Cancer risk is a direct consequence of elevated c-MYC expression from increased distal enhancer activity and not from reorganization/creation of the large chromatin loop., Pisosterol induces interphase arrest in HL60 cells with c-MYC amplification., Studies indicate a role for Myc in stimulating glutamine catabolism, in part through the repression of miRNAs miR-23a and miR-23b., Concomitant and successive amplifications of MYC in APL-like leukemia., Double-hit lymphoma with concurrent IGH-BCL2 and MYC rearrangments is a high-grade B-cell neoplasm with a poor prognosis, resistance to multiagent chemotherapy, and clinical and pathologic features distinct from other high-grade B-cell neoplasms., JAG2 is a direct Myc target and Jagged2 and Notch signaling participate in P493-6 lymphomagenesis., MYC is necessary to specifically maintain an invasive and migratory state of tumors., Increased expression of cmyc was associated with esophageal squamous cell carcinoma., c-myc overexpression during transformation of mammary epithelial cells (MEC) is involved in EMTs via ERK-dependent GSK-3beta inactivation and subsequent snail activation., Promoter activity analysis revealed that hepatitis B virus X protein is directly involved in the c-Myc-mediated transcriptional activation of HSP90alpha., miR-9 miRNA downregulates E-cadherin. Expression of miR-9 is activated by MYC and MYCN, which bind to the mir-9-3 locus. Elevated expression of miR-9 may contribute to epithelial-mesenchymal transition and metastasis in some and possibly many tumours., a strong correlation between the expression of PTB-1, YB-1 and c-myc in multiple myeloma-derived cell lines, L11 suppresses c-Myc-dependent and RNA polymerase III-catalyzed transcription of 5 S rRNA and tRNA genes in response to ribosomal stress, ensuring a tight coordination between c-Myc activity and ribosomal biogenesis., miR-34c is a critical regulator of c-Myc expression following DNA damage acting downstream of p38 MAPK/MK2, and miR-34c serves to remove c-Myc to prevent inappropriate replication which may otherwise lead to genomic instability., Nuclear reprogramming independent of c-MYC enhances production of pluripotent stem cells with innate cardiogenic potential., our results suggest regulation of the EpRE/Nrf2 signaling pathway by c-Myc through both interaction with the EpRE binding complex and increased degradation of Nrf2., analysis of regulation of ATP-binding cassette transporter genes by Myc factors generates specific transcription signatures that significantly affect the chemoresistance phenotype of cancer cells, analysis of the time dependence of c-Myc transactomes mapped by Array-based nuclear run-on and their transcriptional modules in human B cells, The oncogene c-myc is overexpressed in human laryngeal cancer tissues, and may play an important role in carcinogenesis and progression., Increased MYC gene copy number and thus increased mRNA levels ism associated with diffuse large B-cell lymphoma., The HIV-1 p17 activates the transcription factors c-Myc and CREB in human B cells., Gemcitabine can induce apoptosis and down-regulate c-myc gene expression significantly in HL-60 cells., PC-1 enhances c-myc gene expression in prostate cancer cells through the Wnt/beta-catenin pathway., Study finds that the transcription factor c-Myc, a key regulator of cellular proliferation, plays a major role in Pol II pause release rather than Pol II recruitment at its target genes., Ectopic expression of the let-7 family in nasopharyngeal carcinoma cells resulted in inhibition of cell proliferation through downregulation of c-Myc expression., we find that a primarily nuclear or mixed nuclear and cytoplasmic staining pattern for c-myc in an aggressive B-cell lymphoma is highly predictive of a c-MYC translocation, data are presented showing that each risk locus bears epigenetic marks consistent with enhancer elements and forms a long-range chromatin loop with the MYC proto-oncogene located several hundred kilobases telomeric., we describe an interesting oncogenic mechanism in chronic lymphocytic leukemia patients resistant to fludarabine by which the complete MYC-specific regulatory network was altered, These data suggest that dynamically composed protein complexes that dock via vitamin D receptor to the two vitamin D response elements may explain the repression of the MYC gene., In DLBCL, rearrangement of MYC is rarely found as the sole genetic abnormality and the poor prognosis of these patients is likely to reflect a synergistic effect alongside deregulation of BCL6 or BCL2., hTERT transcription requires constitutive expression of Reptin and its cooperation with c-MYC, Pim1 promotes tumorigenicity at least in part by enhancing c-MYC transcriptional activity in human prostate cancer cells., These results indicate that cytokinesis failure and tetraploidy in cancer cells are directly linked to cellular hyperproliferation via c-Myc induced overexpression of GpIbalpha., TRPC4AP/TRUSS binds specifically to the Myc C terminus and promotes its ubiquitination and destruction through the recognition of evolutionarily conserved domains in the Myc N terminus, Meisoindigo can affect the Wnt signal pathway through inhibiting GSK-3beta expression and down-regulating beta-catenin and c-MYC protein expression, which play an important role in the treatment for chronic myeloid leukemia., miR-22 acts as a tumor suppressor through direct repression of MYCBP expression and subsequent reduction of oncogenic c-Myc activities., Results indicate that in addition to c-Myc, mir-29b-1/mir-29a expression can be suppressed by hedgehog signaling and inflammatory pathways, both commonly activated in the genesis of malignancies., Myc is required for the maintenance of Kaposi's sarcoma-associated herpesvirus latency., c-myc was altered in 35% of the oral squamous cell carcinoma samples from a Serbian population. Statistical association with tumour natural history was poor, indicating high clonal heterogeneity and multiple pathways of carcinogenesis., Periplocin from Cortex periplocae inhibits cell growth and down-regulates survivin and c-myc expression in colon cancer., Nfkb2 is suppressed by c-Myc and harnesses Myc-driven lymphomagenesis., C-MYC copy number increases are associated with medulloblastoma., Increased MYC gene copy number and 8q24 allelic imbalance is associated with primary prostate cancer., The results of a biophysical characterization and computational study of an ensemble of intramolecular i-motifs that model the polypyrimidine sequence in the human c-MYC P1 promoter, are reported., Data indicate that the addiction of MYCC-amplified ovarian cancer cells to MYCC differs from the dependence of MYCC non-amplified cancer cells on MYC paralogs, but both are mediated, at least in part, by p27(Kip1)., the dup(11)(q23q13), in absence of the MYC gene rearrangement, is connected with borderline lymphomas with a morphology similar or identical to that of the Burkitt lymphoma., Study reports the identification of Myc-nick, a cytoplasmic form of Myc generated by calpain-dependent proteolysis at lysine 298 of full-length Myc., Although the transient repression mediated by Miz-1/c-Myc is independent of de novo methylation, the stable repression by this complex is associated with CpG island methylation of the critical -295 to -95-bp region of the WIF-1 promoter, Myc seems to modulate at least two crucial steps in transcription. i.e., chromatin modifications for initiation and RNAPII pause release for productive elongation., Data revealed the significance of HER2 in the radio-resistance of HER2(+) breast cancer cells through induction of transcription factors NF-kappaB and c-myc, leading to activation of survivin, a downstream target oncogene preventing apoptosis., Data describe the regulatory role of c-MYC over HDAC2 and PcG genes in human multipotent stem cells., C-MYC can promote the growth and proliferation of normal gastric cells, and knockdown of C-MYC can restrain the growth and proliferation of gastric cancer cells, Data show that gastric cancer markers MUC2, and oncogenes c-myc, cyclin E1 were expressed in the gastric carcinoma cell line 3I (MGCC3I)., Elevated C-MYC expression in primary prostate tumor is biologically relevant and may be a predictor of future biochemical recurrence., Data show that the absence of VpreB3 is virtually always associated with wild-type c-MYC alleles., Data support the hypothesis that deregulation of the MYC pathway is the major force driving the pathogenesis of Burkitt's lymphoma., SCFbeta-TrCP binds to Myc by means of a characteristic phosphodegron and ubiquitylates Myc; this results in enhanced Myc stability. SCFFbw7 and SCFbeta-TrCP can exert these differential effects through polyubiquitylation of the amino terminus of Myc, Single nucleotide polymorphism in CMYC is associated with ovarian cancer., The expression of STAT3 and c-myc may play an important role in the tumorigenesis, metastases and poor prognosis of laryngeal squamous cell carcinoma., These results suggest c-Myc could further repress p21 expression at the post-transcriptional level through some, but not all, members of miR-17 family., role in mediating the oncogenic activity of Aurora-A, High-level MYC amplification was found in 100% of secondary Angiosarcoma (AS), but in none of the AVL or other radiation-associated sarcomas. Coamplification of FLT4 (encoding VEGFR3) was identified in 25% of secondary AS, but not in other types., The results reveal that knock-down of the beta-catenin gene decreases expression and nuclear translocation of beta-catenin protein in colon cancer HT-29 cells and suppresses the expression of the beta-catenin-dependent genes cyclin D1 and c-myc., an important relationship between BAFF and c-MYC in CLL which may affect disease development and progression, and suggests that inhibitors of the canonical NF-kappaB pathway may be effective in treatment of patients with this disease., Plasmablastic lymphomas are genetically characterized by frequent immunoglobulin/MYC translocations and gains in multiple chromosomal loci., IL-6 activates c-Myc translation in MM cells by inducing A1 phosphorylation and cytoplasmic localization, study shows decorin blocks several biological activities mediated by Met signaling axis; these effects were mediated by downregulation of noncanonical beta-catenin levels; Myc was downregulated by decorin; phosphorylation of Myc at threonine 58 was induced, The reason for the aggressive behaviour is the overexpression of pro-proliferative (MYC) and anti-apoptotic (BCL2, BCL6) oncoproteins at the same time., KRAS mutation-positive lung cancer displaying high levels of Myc could be treated by inhibiting Myc transactivation function., A direct correlation analysis showed that ubiquitin-specific protease 22 was strongly correlated with BMI-1 and c-Myc at the mRNA level., regulation of p16, p21, p27 and c-myc is increased by oridonin, which induces apoptosis and senescence in colorectal cancer cells, gain of MYC can contribute to the pathogenic effect of the most common trisomy of human acute myeloid leukemia (AML)., Myc-driven reprogramming of microRNA expression patterns contributes to the aggressive phenotype of liver tumors originating from hepatic progenitor cells., findings indicate that single point mutations in of the MBII domain of Myc can genetically uncouple transformation from several of the phenotypes that contribute to and are closely associated with the transformed state, Prescence of of APOEepsilon4 allele and MAPT H2 found a point mutation affecting codon 34 (GGA --> GTA) of beta-Catenin gene resulting in a Glycine --> Valine substitution. No cases presented c-myc/N-myc amplification, miR-145 inhibits proliferation of non-small cell lung cancer cells through c-Myc, Findings suggest that the pattern of c-MYC expression, particularly its later decline, is key to producing functional platelets from selected iPSC clones., In medulloblastoma, c-MYC copy number gains and transcriptionally by enrichment of photoreceptor pathways and increased miR-183 approximately 96 approximately 182 expression, is associated with significantly lower rates of event-free and overall survivals., C-MYC and BMI-1 expression was detected in stromal cells only, gene expressions were significantly higher in the cancer group and may serve as reliable biomarkers to monitor tumour development and the efficiency of therapy, c-myc siRNA significantly reduces c-myc and h-tert mRNA and protein expression levels through inhibiting c-myc mRNA expression and decreasing intracellular level of C-MYC protein in Jurkat cells., Data show that four transcription factors Oct4, Sox2, Klf4 and c-Myc can be used to directly generate induced EpiSCs (iEpiSCs) under EpiSC culture conditions., Findings support a role for the AKT-dependent regulation of AIP4/Itch activity in mediating the differential cyclin D1 and c-MYC transcriptional responses to rapamycin., a negativie correlation between the expressions of STAT3 and WWOX, but no relationship was found between WWOX and c-myc, MYC amplification is a prognostic marker of patients with early-stage lung adenocarcinoma, combined expression of three genes-MYC, EGFR and FGFR2-was an independent predictor for overall survival of 27 CF-treated patients in the validation set, and also for survival of 40 chemotherapy-treated gastric cancer patients, Pim-3 has an important role in modulating c-Myc and PGC-1alpha protein levels and cell growth, report that NOTCH(IC) is able to maintain T-cell acute lymphoblastic leukemia tumors formed in the presence of exogenous NOTCH(IC) and c-MYC when exogenous c-MYC expression is extinguished, TP53INP1 is a tumor suppressor in esophageal squamous cell carcinoma (ESCC0; c-Myc-mediated DNA methylation-associated silencing of TP53INP1 contributed to the pathogenesis of human ESCC., study identifies miR-378-TOB2-cyclin D1 as a functional module to mediate the cross talk between Myc and Ras signaling in cellular transformation, SKP2 is a direct MYC target gene and that MYC-mediated SKP2 induction leads to reduced p27 levels. The results suggest the induction of SKP2 oncogene as a new mechanism for MYC-dependent transformation, Data show that the inhibition of HMG-CoA reductase may be a useful target for the treatment of MYC-associated HCC as well as other tumors., XPD may play an important role in cell apoptosis of hepatoma by inducing an over-expression of p53, but suppressing expressions of c-myc and cdk2, Data show that CD26 mRNA and protein levels increase in a confluence-dependent manner in colon carcinoma cell lines, with c-Myc acting as a repressor and Cdx2 acting as an enhancer of CD26 expression., High expression of c-myc protein is associated with surgical molecular margin in colorectal carcinoma., Higher rates of the expressions of both APC and c-Myc proteins in non-small cell lung cancer primary foci were found compared with those in lymph node metastases., findings indicate high MYC levels drive BMP7 overexpression, promoting cell survival in medulloblastoma cells suggesting the potential relevance of targeting the BMP/SMAD pathway as a novel therapeutic approach for the treatment of childhood MB, c-MYC expression sensitizes medulloblastoma cells to radio- and chemotherapy and has no impact on response in medulloblastoma patients., Erythromycin could restrain the proliferation of SH-SY5Y cells by downregulating c-myc and upregulating WAF1., gene expression signature from human breast cancer cells with acquired hormone independence identifies MYC as a mediator of antiestrogen resistance, The high incidence of TP53 mutations and absence of amplification of c-myc and N-myc genes indicates that supratentorial neuroectodermal tumors are a specific subset of these CNS tumors., a monitoring mechanism of c-Myc and ASK1/p38 against abnormal ribosome biogenesis through controlling the stability and activity of p53 protein, Human mixed transcription factor/microRNA feed-forward Loops, having Myc as master regulator, was characterized., Co-occurrence of MYC amplification and PI3K-pathway alteration was observed, raising the possibility that these two lesions cooperate in prostate cancer progression., Down-regulation of Thanatos-associated protein 11 by BCR-ABL promotes CML cell proliferation through c-Myc expression, Temozolomide induced c-Myc-mediated apoptosis via Akt signalling in MGMT expressing glioblastoma cells, Studies indicate that many prognostic signatures reflect the activity of the MYC oncogene, which in turn regulates tumor metastasis through specific effects on cancer cell invasion and migration., Data suggest that the joint overexpression of MCL1 and MYC may be a useful biomarker for both prognosis and treatment in NSCLC., C-myc underexpression might be a central event in adrenortical tumourigenesis based on network topology modelling., expression of reprogramming marker c-Myc, was detectable in the early passaged DPCs, and sequential loss of this marker in nucleus during DPC cultures might be related to the cell fate of pulp derived cells during the long-term in vitro cultivation., overexpression of the MYC oncogene increases nucleolar number and size and a nucleolar program of gene expression in prostate epithelial cells, characterized three novel human cell line models of Myc-dependent transformation, A model has been proposed in which increased abundance of c-MYC indirectly leads to decreased BIN1 expression, in turn leading to increased PARP activity and resistance to DNA-damaging agents., MYC in chronic myeloid leukemia, MYC is activated in 67% of myeloma, but not in MGUS; almost all tumors with RAS mutations expressed the MYC activation signature, and multiple mechanisms may be involved in activating MYC., high expression levels of c-myc genes were found to be closely associated with more aggressive forms of the disease B-cell chronic lymphocytic leukaemia, several miRNAs must be coordinately down-regulated to enhance critical oncogenes, such as Myc., Copy number changes at 11q13 and 8q34 harboring CCND1 and MYC, respectively, are highly associated with prognosis in melanoma skin cancer., Posttranscriptional deregulation of MYC via PTEN constitutes a major alternative pathway of MYC activation in T-cell acute lymphoblastic leukemia., findings suggest that the architecture of the MYC promoter is comprised of distal elements that are juxtaposed through large chromatin loops and that ss-catenin/TCF4 complexes utilize this conformation to activate MYC expression in colon cancer cells, ll patients with co-overexpression of bcl-2 and c-myc oncogenes will have PVU invasive carcinoma, down-regulation of c-Myc expression can inhibit the invasion of Cholangiocarcinoma cells in vitro., Observations reveal that organization does not alter the inherent response of epithelial cells to Myc and suggest that other tumor suppression mechanisms, apart from structure, antagonize Myc in the development of solid tumors., findings imply that cucurbitacin B exerts an anticancer effect by inhibiting telomerase via down regulating both the hTERT and c-Myc expression in breast cancer cells., HepaCAM induces G1 phase arrest and promotes c-Myc degradation in human renal cell carcinoma., following irradiation, HER2 receptor activates hTERT/telomerase, increasing the breast cancer cells' survival potential, through sequential induction of transcription factors NF-kappaBeta and c-myc, Translocation of the BCL2 gene on the chromosome band 18q21.3 and MYC translocation to 14q32/IGH or less commonly to 2p11/IGK in an identical cell is termed BCL2 and MYC dual-hit lymphoma/leukemia[review], Nuclear expression of c-myc in primary breast tumors correlated with an increased risk for axillary lymph node metastasis., Data suggest that Bcl-2 is a better therapeutic target than c-Myc, but attacking both Bcl-2 and c-Myc would be an even more effective treatment strategy for diffuse large B-cell lymphomas., c-myb mRNA as the first natural translational target mRNA of Pdcd4, Pim3 cooperates with other Pim kinases in supporting viability of Myc-induced B-cell lymphomas., We analyzed neovascularization and c-myc expression in 36 medulloblastoma specimens., Depletion of c-Myc was correlated with reduced expression levels of BRCA1. c-Myc bound to 2 similar tandem clusters in the BRCA1 distal promoter., MYC(+)translocation cases of diffuse large B-cell lymphoma showed significantly poorer overall survival and progression-free survival., c-MYC-driven transcriptional events, combined with epigenetic mechanisms, direct and regulate the expression of ABC genes with possible implications in tumor malignancy and drug efflux in chronic myeloid leukemia., describes the functions of c-myc and its role as oncogene, assessing its expression by immunohistochemistry and genetic amplification studies [review], there was significant correlation between C-MYC amplification and grading and highly significant correlation between C-MYC amplification and hTERC amplification., Results suggest that c-myc amplification is significantly associated with a high pCR (pathological complete response) rate to P-FEC chemotherapy in breast cancers, especially in ER-positive tumors., Data suggest that in some systems p21(CIP) takes part in a mitosis control driving MYC-induced cellular growth into differentiation., Data suggest that SYUIQ-05 had its antitumor activity for cancer cells mainly through its interaction with c-myc quadruplex., Androgen suppresses proliferation of 104-R2 cells by inducing G(1) cell cycle arrest through reduction of c-Myc., results reinforce the notion that EBV infection and MYC rearrangements are important events in the pathogenesis of oral plasmablastic lymphomas, Alterations in the microRNA genes may be an alternative mechanism leading to MYCC overexpression in medulloblastomas., an important role for HuR in hypoxia, and we may have revealed a novel post-transcriptional mechanism that controls c-Myc expression in oral cancer progression., Results identify a novel regulatory paradigm wherein L11 plays a critical role in controlling c-myc mRNA turnover via recruiting miR-24/miRISC in response to ribosomal stress., These results reveal an important mode of Myc activation in human breast cancer and a mechanism contributing to Myc deregulation involving unique insight into inactivation of the Axin1 tumor suppressor in breast cancer., These results demonstrate a novel pathway of estrogen regulation of gene expression by cooperation between ER and AP-1 at the distal enhancer element and that AP-1 is involved in estrogen induction of the c-myc oncogene., Interplay of Wnt and c-MYC signaling during intestinal homeostasis and transformation., dysregulation of the BMI1 gene mediated by MYCN or MYC overexpression, confers increased cell proliferation during neuroblastoma genesis and tumor progression, COX-2 inhibitors slow down cell proliferation of leukemic and lymphoblastic cell lines by downregulating c-Myc., MYC or eukaryotic translation initiation factor 4E (eIF4E) was required to bypass pharmacological PI3K/mTOR inhibition in resistant cells., AKT cooperated with the transcription factor c-MYC to synergistically activate rRNA synthesis and ribosome biogenesis, MYC aberrations are common in unclassifiable B-cell lymphoma., Modest overexpression of cMyc is able to drive proliferation without cell death in normal rat and human beta-cells., the expressions of p53, c-MYC, BCL-2 protein and apoptotic index could be used as potential biomarks for predicting the progression and prognosis of osteosarcoma, let-7d via noncanonical E-box., analysis of N-Myc and c-Myc synthesis, degradation, and transcriptional activity by the Ras/mitogen-activated protein kinase pathway, MYC amplification represents an important additional diagnostic tool in the distinction of postradiation cutaneous angiosarcomas from atypical vascular lesions after radiotherapy for breast carcinoma., data provide new insights into the role of c-Myc activity in different lymphomas and raises the question of treatment changes for those patients under risk, FoxO3A is recruited to the promoters of nuclear-encoded mitochondrial genes where it directly antagonizes c-Myc function via a mechanism that does not require binding to the consensus FoxO recognition element., The results implicate EZH2-driven mechanisms by which Myc may stimulate prostate tumor initiation and disease progression., found that myeloma cells harboring immunoglobulin (IG)-MYC translocations evaded BMP-induced apoptosis, suggesting a novel way for myeloma cells to overcome potential tumor suppression by BMPs, Pharmacologic inhibition of MYC is achievable through targeting BET bromodomains., the inhibition of NMD may play an important role in the dynamic regulation of genes by Myc., c-MYC is an important molecular switch that alters the cellular response to oncostatin M-mediated signaling from tumor suppressive to tumor promoting., Endogenous MYC regulates BAG1 transcription in nontransformed cells., MYCT1-TV, a novel MYCT1 transcript, is regulated by c-Myc and down-regulation of MYCT1-TV/MYCT1 could contribute to LSCC development and function, The findings highlighted the role of HDAC3 in Myc-induced miR-15a/16-1 changes and reveal novel mechanisms for c-Myc-driven microRNA suppression and malignant transformation in aggressive B-cell malignancies., B-cell lymphomas with MYC/8q24 rearrangements and IGH@BCL2/t(14;18)(q32;q21) appear to behave as poorly as MYC/BCL2 lymphomas, possibly expanding the disease spectrum., Induction of c-Myc by amyloid-beta peptide, camptothecin or other disease factors may be a key mediator in cell cycle activation and consequent cell death that is a feature of neurodegenerative diseases., c-myc is highly expressed in laryngeal squamous cell carcinoma. c-myc siRNA inhibits c-myc gene expression and reduces cell proliferation., c-Myc activation resulted in the down-modulation of proteins involved in cellular senescence., SOX2 might have a specific function by regulating DKK1 and c-MYC in the differentiation and growth of ASCs, which is separate from its roles in ESCs., functional interaction between OTX2 and MYC in regulating gene expression in medulloblastoma, An E-box-independent mechanism is identified for transcriptional regulation by MYC that unveils previously unknown functions for MYC in differentiation., The Notch ankyrin repeat domains differ in their leukemogenic potential, and that this difference correlates with activation of Myc., Data show that the expression of GLIPR1 and c-Myc were inversely correlated in prostate cancer., Data support a model where the deregulation of a network involving 14q32 miRNAs, cMYC and miR-17-92 miRNAs could contribute to osteosarcoma pathogenesis., Gas41 is able to bind both n-Myc and c-Myc proteins, and that the levels of expression of Gas41 and Myc proteins were similar to each other in such brain tumors as neuroblastomas and glioblastomas., NS functions downstream of Myc as a rate-limiting regulator of cell proliferation and transformation., A more tailored subgrouping system based on expression profiles of chromosome 17p, MYCC, and MYCN, which may provide the basis for a novel risk-stratification strategy in pediatric medulloblastoma., results suggest that, in addition to the indirect mechanisms that appear to mediate the antiproliferative properties of 1,25-(OH)2D3 in colorectal cancer cells, the hormone also exerts direct effects on both c-FOS and c-MYC, Cytogenetic analysis of high-grade lymphoma samples identified a MYC-IGK juxtaposition in seven patients and three translocation t(2;8)-positive cell lines., Amplification of MYC and nuclear expression of MYC is present in secondary angiosarcoma but not AVL, MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells., Transcriptional regulation of MIR29B by PU.1 (SPI1) and MYC during neutrophil differentiation of acute promyelocytic leukaemia cells., let-7a acts as a tumor suppressor in RCC cell lines by down-regulating c-myc and c-myc target genes., loss of SAE1/2 activity drives synthetic lethality with Myc; inactivation of SAE2 leads to mitotic catastrophe and cell death upon Myc hyperactivation; findings in Myc-high breast cancers suggest low tumor SAE1 and SAE2 correlates metastasis-free survival, C-myc up-regulated miR-1245 expression which led to down-regulation of BRCA2., Overexpression of c-Myc reversed miR-34a suppression of RhoA expression and inhibition of cell invasion., AID may act as a negative regulator of cell survival in follicular lymphoma when sufficient c-myc is expressed, Transfection of DLL4 into K562 cells increased the protein expression levels of transcription factor YY1 and proto-oncogene c-Myc, which slowed cell proliferation and increased apoptosis., Imidazo [4,5f][1,10] phenanthroline derivatives inhibits the c-myc gene expression in A549 cells via NF-kappaB pathway, Review of the role of Myc in liver cancer.[review], the networks acting downstream of MYC and p63 genes to control epidermal homeostasis, our findings uncover a previously uncharacterized regulatory relationship between Myc and HIF1 that has important implications for cancer metabolism and development., Chronic lymphocytic leukemia/ prolymphocytic leukemia with MYC translocations is a rare entity, which seems to be associated with adverse prognostic features and unfavorable outcome., a novel role of miR-34a in the regulation of transcription by c-Myc complex, Polyphenols up-regulated HIF-1alpha and down-regulated c-Myc, PHD2 and beta-catenin expressions via SIRT1 activation, in a manner that mimics hypoxic preconditioning., The results both validated CIP2A's role in regulating MYC-mediated gene expression and provided a plausible novel explanation for the high MYC activity in basal-like and HER2thorn breast cancers., These data identify two regulatory mechanisms for vav1 expression, We demonstrate that c-MYC gain alone, or combined c-MYC gain and PTEN loss, were increasingly prognostic for relapse, this study identifies a novel mechanism for pVHL-mediated negative regulation of c-Myc transcription., DYRK2 regulates tumor progression through modulation of c-Jun and c-Myc, Overexpression of CIP2A in colorectal cancer patients may be an important step in colorectal carcinogenesis. Based on our findings, CIP2A shows no association with patient prognosis in colorectal cancer, but is associated with nuclear c-Myc., Immunostaining for Myc protein is an excellent screening test to predict whether an MYC rearrangement is present in diffuse large B-cell lymphoma., Thymic stromal lymphopoietin may upregulate c-Myc expression through activation of STAT3 pathway, thereby inducing trophoblast proliferation., Increased glutamine catabolism in MYC-induced liver tumors is associated with decreased levels of glutamine synthetase (Glul) and the switch from Gls2 to Gls1 glutaminase., The decrease in c-MYC in patients with hypopituitarism provides the first in vivo evidence for hormonal regulation of c-MYC expression., c-Myc activation through CXCL13-CXCR5 signaling axis stimulates RANKL expression in stromal/preosteoblast cells. Thus, our results implicate CXCL13 as a potential therapeutic target to prevent OSCC invasion of bone/osteolysis, The contribution of NFAT to the regulation of c-Myc expression may depend on a balance between the binding to positive and negative NFAT-responsive elements., The disease is associated with Epstein-Barr virus and was one of the first tumours shown to have a chromosomal translocation that activates an oncogene (c-MYC)., we found a strong correlation between Myc protein downregulation and the expression of the transcription factor Cdx2, suggesting the existence of a regulative link between these two proteins., Upreg'n of miR-17-92 cluster was seen in MYC-amplified AS compared to AS lacking MYC amplification and controls. Moreover, MYC-amplified ASs were associated with a significantly lower expression of THBS1 than AS without MYC amplification or controls., Max b-HLH-LZ can transduce into cells and inhibit c-Myc transcriptional activities, BCL-X(L) and BCL-2 but not FLIP(L) acts in synergy with MYC to drive AML development, ErbB receptors might regulate AP-1 protein expression via two pathways, rs67491583 was identified as another functional variant in the CRC-associated enhancer MYC-335, but further studies are needed to establish the role of rs67491583 in the colorectal cancer predisposition of African Americans., results indicate that aggressive breast tumors with elevated MYC are uniquely sensitive to CDK inhibitors, Findings indicate that SirT1 confers a higher radioresistance in hypoxic cells than in normoxic cells due to the decreased levels of c-Myc protein and its acetylation, and that a c-Myc-dependent radiation-induced phosphorylated p53 may be involved., Kaposi sarcoma-associated herpesvirus vIRF-3 protein binds to F-box of Skp2 protein and acts as a regulator of c-Myc protein function and stability., Proto-Oncogene Proteins c-myc controls c-MYC controls transcription of MCL1 directly, regulation of BCL(XL) was due to c-MYC's capability to regulate the eIF4E gene, which encodes a rate-limiting factor of eukaryotic translation., Describes the development of humanized mouse model of MYC/BCL2-driven 'double-hit' lymphoma. By engrafting human HSCs transduced with the oncogene combination into immunodeficient mice, we generate a fatal B malignancy with complete penetrance., NKX3.1 and MYC coregulate prostate tumorigenesis by converging on, and crossregulating, a common set of target genes., Data indicate that altered FIR and c-myc pre-mRNA splicing, in addition to c-Myc expression by augmented FIR/FIRDeltaexon2-SAP155 complex, potentially contribute to colorectal cancer development., Unphosphorylated c-Myc interacts with retinoic acid receptor alpha (RARalpha) to repress the expression of RAR targets required for differentiation, thereby aggravating leukemia malignancy., presentation of hypothesis that therapeutic actions of exercise over human lifespan are mediated by signaling through Myc network of transcription factors (Myc, Max, Mlx, Mad) [REVIEW], This is the first report of c-Myc being regulated by a bona-fide chaperone-associated E3 ligase in HEK293 as well as glioma cells., SRSF1 is a direct target of the transcription factor oncoprotein MYC., Transcription factors c-Myc and CDX2 mediate E-selectin ligand expression in colon cancer cells undergoing EGF/bFGF-induced epithelial-mesenchymal transition., Human embryonic palatal mesenchymal proliferation is manifested by the induction of c-Myc in response to TGFbeta signaling, which is essential for complete palatal confluency., These results suggest that CNA of MYC and FHIT are poor prognostic markers, and risk stratification based on the copy-number status of those genes is useful to select the optimal treatment strategy in resected ESCC patients., show further that MYC represses transcription of both subunits of alphavbeta3 integrin, and that exogenous expression of beta3 integrin in human breast cancer cells, respiratory epithelial polygonal and cuboidal cells have distinct expression of beta-catenin, Axin, and C-myc, MYC suppressed proline oxidase (POX/PRODH) expression primarily through up-regulating miR-23b*., Our findings implicate amplifications of 3q26 focused on PIK3CA and 8q24 focused on MYC in chronic lymphocytic leukemia., Novel c-Myc targeted genes were identified and may contribute to hepatocyte transformation by altering cell cycle control, thereby contributing to c-Myc's oncogenic activity., c-Myc globally regulates the immunogenicity of transformed B cells, acting on export of secretory lysosomes to plasma membrane., these results demonstrate an essential role for NPM in c-Myc nucleolar localization and c-Myc-mediated rDNA transcription., myc expression associated with poor outcome in R-CHOP treated diffuse large B-cell lymphoma, Myc expression was higher in pancreatic neoplasms and positively correlated with perineural invasion., Elevated levels of c-Myc correlate with the overexpression of GPC3 in human Hepatocellular Carcinoma samples., present the solution structure of the NPM1-C70 domain and NMR analysis of its interaction with a c-MYC-derived G-quadruplex. These data were used to calculate an experimentally restrained molecular docking model for the complex, MYC inhibits differentiation by antagonizing the imatinib-mediated upregulation of p27., Increased levels of decondensed chromatin in both normal progenitor cells and cancer cells are associated with global loss of H3K27me3, which is linked to MYC overexpression., New structural determinants for c-Myc specific heterodimerization with Max and development of a novel homodimeric c-Myc b-HLH-LZ., The LAT1 promoter has a canonical c-Myc binding sequence and overexpression of c-Myc increased LAT1 promoter activity., In acute leukemic cells and leukemic bone marrow stromal cells, c-myc expression positively correlated with c-myb expression., It was demonstrated that hTERT, MYC, and TP53 are deregulated in intestinal metaplasia of individuals from northern Brazil and these alterations may facilitate tumor initiation., Furthermore, we show for the first time that expression of the transcription factor c-myc, which is phosphorlyated by Erk2, is required for EMT, Pdcd4 knockdown up-regulates MAP kinase kinase kinase kinase 1 (MAP4K1) expression and increases phosphorylation of c-Jun., 60% are double-hit lymphomas., Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc., It was concluded that extracellular kinase-mediated up-regulation of c-myc by K-Ras or B-Raf oncogenes disrupts the establishment of apical/basolateral polarity in colon epithelial cells independently of its effect on proliferation., Constitutive c-Myc expression enhances CD19 expression and phosphorylation on active sites in transgenic mice with B cell lymphoma., Data show a combination of only five genes (-BCL6, T (BRACHYURY), c-MYC, MITF and BAF60C (SMARCD3) rapidly and efficiently convert postnatal chorion and decidual cells into chondrocytes., Our findings establish the impact of Oct1, KLF4 and c-Myc on cancer bioenergetics and evidence a link between oncosecretomics and cellular bioenergetics profile., Rabring7 stimulates c-Myc degradation via mono-ubiquitination of MM-1, poor prognostic effect of MYC positive/BCL2 in diffuse large B-cell lymphoma, TTP suppression is a hallmark of cancers with MYC involvement, and restoring TTP impairs Myc-induced lymphomagenesis and abolishes maintenance of the malignant state., The human nuclear poly(ADP-ribose)polymerase-1 (h PARP-1) protein participates in the regulation of the h c-myc gene expression through its interaction with this guanine-quadruplex structure., c-MYC mRNA/protein expression levels were increased in ectopic tissue in peritoneal endometriosis., In this work, the authors identified miR-33b as a primate-specific negative regulator of c-Myc., Data suggest that X protein (HBx) and c-Myc work cooperatively to support ribosome biogenesis and cellular transformation., Deregulated c-MYC and PI3K activity cooperate in Burkitt lymphoma pathogenesis., We found that overexpression of c-Myc was significantly associated with that of BMI1, and that patients who harbored glioblastomas overexpressing c-Myc and BMI1 showed significantly longer overall survival., High c-Myc expression in breast cancer was associated with tumor progression., results demonstrate that Sp1 and Myc regulate CD133 transcription in glioma stem cells and promoter methylation and methyl-DNA-binding proteins cause repression of CD133 by excluding transcription-factor binding., myc translocation confer a worse prognosis in diffuse large B-cell lymphoma treated with CHOP, Data suggest that BIBR1532 caused rapid cell death in Nalm-6 cells probably through transcriptional suppression of survivin-mediated c-Myc and human telomerase reverse transcriptase (hTERT) expression in a concentration-dependent manner., markers were associated with patient outcome in DLBCL. A new algorithm discriminating BL from DLBCL emerged, including the expression of CSE1L, STAT3, and MYC translocation, Dominant up-regulation of MYC by rs6983267 single nucleotide polymorphism is associated colorectal cancer., Data indicate that SIRT1 is overexpressed in thyroid cancers and it is positively correlated with c-MYC protein levels., MYC gains progressively increased during penile squamous cell carcinoma progression from in situ samples to metastases. MYC gains were an independent factor for poor prognosis, Wanted to i.d. recurrent alterations associated w/MYC rearrangements in aggressive B-cell lymphomas w/complex karyotypes. Several patterns of genomic aberrations were identified in childhood Burkitt lymphomas/leukemias and diffuse large B-cell lymphomas., Analyzed the MYC amplification status of 83 radiation-induced sarcomas (RIS) and 192 sporadic sarcomas by fluorescence in situ hybridization and found significantly higher numbers of MYC amplifications in RIS than in sporadic sarcomas., Myc immunohistochemistry is a potential marker for inferior event-free survival in diffuse large b-cell lymphoma patients., SIRT1 expression supports liver tumorigenesis and is closely correlated with oncogenic c-MYC expression. In addition, both SIRT1 and c-Myc may be useful prognostic indicators of hepatocellular carcinoma., c-MYC may come under negative regulation by p150, consistent with the action of p150 as a putative tumor suppressor., MYC translocation was more common in germinal center B cell-like (GCB) type diffuse large B-cell lymphoma (DLBCL) compared with non-GCB type ones., Up-regulation of c-MYC expression correlates with malignant transformation in the serrated route to colorectal cancer., p62-positive, TDP-43-negative inclusions, characteristic of C9ORF72 mutations, were present in the cerebellum and hippocampus, CDH1 was most commonly lost, and gain of MYC emerged during progression from ductal carcinoma in situ to invasive ductal carcinoma., it appears that c-Myc plays a central role in sustaining the changes which occur with transformation, demonstrate that miR-29 is repressed by MYC through a corepressor complex with HDAC3 and EZH2, show that MLL fusion proteins negatively regulate production of miR-150, an miRNA widely repressed in acute leukemia, by blocking miR-150 precursors from being processed to mature miRNAs through MYC/LIN28 functional axis, findings show C-MYC upregulates transcription of TIP110 through interaction with the TIP110 E-box in the TIP110 promoter, ensuring high-level Tip110 expression in proliferating embryonic stem cells (hESCs); further show TIP110 regulates OCT4 alternative splicing in hESCs, High c-myc expression in the cytoplasm is associated with prostate cancer., c-MYC down-regulation caused by cohesin mutations in SMC1A and SMC3 genes may be an early/primary event in the pathogenesis of Cornelia de Lange syndrome., c-Myc expression was augmented in non-tumoral liver tissues from HCV-infected individuals with or without HCC and in hepatocyte cell lines harboring an HCV replicon and the infectious HCV strain JFH1., Overexpression of FIR and its splicing variants in colorectal cancer directs feed-forward or addicted circuit c-myc transcriptional activation., MYC acts via the PTEN tumor suppressor to elicit autoregulation and genome-wide gene repression by activation of the Ezh2 methyltransferase., A role for the unfolded protein response as an enhancer of c-Myc-induced neoplastic transformation., c-Myc induction of CCAT1 holds an important role in gastric carcinoma., these results demonstrate a novel role for cohesin in estrogen-mediated regulation of MYC and the first evidence that cohesin plays a role in ERalpha binding, c-MYC amplification is highly correlated with advanced stage and deeply invasive mucinous gastric carcinoma, Myc overexpression has been recognized in other aggressive B-cell lymphomas and has been linked to adverse prognosis., together, our results suggest that c-myc, p53, C-erbB-2 and COX-2 proteins do not correlate with cancer stage or follow-up in Esophageal squamous cell carcinoma, STK38 regulates MYC protein stability and turnover in a kinase activity-dependent manner. STK38 kinase inactivation abrogates apoptosis following B-cell receptor activation, whereas its silencing significantly decreases MYC levels and increases apoptosis., Tob is a key factor in the regulation of c-myc gene expression, which is essential for cell growth., that the serine-threonine kinase PBK/TOPK is frequently overexpressed in high-grade lymphomas and its expression is positively correlated to that of c-Myc and E2F1, The results revealed c-Myc-dependent regulation of HIF-1alpha instead of HIF-1alpha-dependent c-Myc regulation for the first time., Results thus identify a novel epigenetic mechanism by which MYC activates GATA4 leading to metastasis in lung adenocarcinoma., Transforming growth factor-beta directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas, Report essential roles for ribonucleotide reductase and thymidylate synthase in C-MYC-dependent suppression of senescence in melanoma cells., Transcriptional regulation of target genes by association with gene regulatory chromatin in cooperation with c-Myc by nuclear DeltaEGFR makes a unique contribution to its oncogenicity., High c-myc expression is associated with breast cancer., MYC regulation of CHK1 and CHK2 promotes radioresistance in a stem cell-like population of nasopharyngeal carcinoma cells., We now demonstrate that protection from double-strand break damage in ER+ cells is mediated via regulation by c-myc, p53, CBP and SRC1 coactivators in intron 1 of the NBS1 gene, c-Myc suppression of double-strand break repair and V(D)J recombination may occur through inhibition of the nonhomologous end-joining pathway., Abl signaling can indirectly augment acetylation of Myc by p300, and its transcriptional activity in the nucleus; Abl can directly phosphorylate Myc on tyrosine and its presence correlates with Abl activation in cancer., Our study provides further evidence supporting the concept of "double hit" mantle cell lymphoma with co-involvement of MYC gene rearrangement and/or amplification and CCND1 gene rearrangement., Protein expression patterns of MYC, BCL2 and BCL6, and MYC rearrangements were predictive of outcome and provided prognostic information independent of the International Prognostic Index (IPI) for overall survival and event-free survival., Conclude that up-regulation of ID2 contributes to anti-tumour activity of decitabine via repression of Ig locus activity and consequently MYC expression., Clusters of MYC signals may be an underappreciated, but clinically important, feature of aggressive B-cell lymphomas with potential prognostic and therapeutic relevance., MYC rearrangements are useful for predicting outcomes following rituximab and chemotherapy., Human c-Myc represses E-cadherin at the post-transcriptional level through miR-9., we induced tumors in mice via the injection of transposons encoding three oncogenes(HRAS, c-Myc and shp53) and a plasmid-expressing transposase., pathologically activated in and essential for promoting human hepatocellular carcinoma, results therefore suggest that c-MYC induces stress-mediated activation of ATF2 and ATF7 and that these transcription factors regulate apoptosis in response to oncogenic transformation of B cells, astrocytes coexpressing c-Myc and Akt were tumorigenic when implanted into the brain of immunocompetent C57BL/6 mice, 92 and miR-106a, MYC/BCL2 coexpression, rather than cell-of-origin classification, is a better predictor of prognosis in patients with diffuse large B-cell lymphoma treated with R-CHOP., show that CIP2A expression in rheumatoid arthritis FLS is an important mediator of dysfunctional apoptosis independent of c-Myc stabilization, The enforced expression of c-Myc in fibroblasts can trigger MET, to which cytoskeleton depolymerization and RhoA/Rock pathway inactivation contribute., Overexpression of Myc upregulates Ran expression, whereas knockdown of Myc downregulates Ran expression. Myc or Ran overexpression in breast cancer cells is associated with cancer progression and metastasis., PKA is a regulator of MYC; its different catalytic subunits have distinct biologcial roles, c-Myc was identified as a direct target gene of miR-449c, c-Myc plays a role in G protein-coupled receptor kinase 4 (GRK4) transcriptional regulation in human kidney proximal tubule cells., EGFR and MYC gene copy number aberrations are more common in squamous cell carcinoma than keratoacanthoma., c-MYC directly regulates GLI1 and support an antiapoptotic role for GLI1 in Burkitt lymphoma., a novel regulatory network in molecular apocrine breast cancers regulated by androgen and AR in which MYC plays a central role as both a key target and a cooperating transcription factor to drive oncogenic growth, c-Myc-mediated overexpression of miR-17-92 suppresses replication of hepatitis B virus in human hepatoma cells., findings represent a novel promising approach for silencing MYC-miRNA-EZH2 amplification loop for combinatorial therapy of aggressive B-cell lymphomas, Tumor suppressor miR-375 regulates MYC expression via repression of CIP2A coding sequence through multiple miRNA-mRNA interactions., The presence of MYC duplication or polysomy 8, as well as KRAS mutation, were also associated with the HER2 overexpression subtype (p<0.05)., Chronic lymphocytic leukemia cells respond to B-Cell receptor stimulation with a microRNA/mRNA signature associated with MYC activation and cell cycle progression., It provides a strategy to define a precise molecular picture at a resolution of about 200 mum that may be useful in identifying lipid molecules that define how the MYC oncogene initiates and maintains tumorigenesis., MYC amplification status but not Myc protein expression was significantly predictive of biochemical recurrence after prostatectomy, Increased translation of c-myc mRNA occurs with sphingosine kinase 1 overexpression, stimulating intestinal epithelial cell proliferation., C-myc, c-jun and c-fos expression values also showed a time-dependent increase in surviving patients., analysis confirms that aCGH is as safe as FISH for the detection of MYC/MYCN gene amplification, COX-2 is insufficient for modifying the hepatocarcinogenesis course mediated by c-myc/TGF-alpha, where miR-17-5p showed a significant down-regulation in 23 non-metastatic HCC biopsies compared to 10 healthy tissues; however, E2F-1 and c-MYC transcripts were markedly elevated, Leptin interferes with the expression of oncogenic c-myc and anti-apoptotic bcl-2, and regulates cell turnover and facilitates the progression of cervical cancer., C-myc-dependent downregulation of VEGF induced by all-trans-retinoic acid contributes to the differentiation of HL-60 cells., Myc-induced metabolic changes are coupled via AMPK and phospho-p53 to the mitochondrial apoptosis effector Bak, showing that there is a cell-intrinsic mechanism to counteract uncontrolled proliferation, The interaction between SAP155 and FIR/FIRDeltaexon2 not only integrates cell-cycle progression and c-Myc transcription by modifying P27 and P89 expression., ALK-positive large B-cell lymphomas express a complete plasmablastic differentiation program but unlike plasmablastic lymphomas do not have MYC rearrangements. STAT3 is constantly activated and may be an alternative mechanism to promote MYC expression., Sp1 and c-Myc are important transcription factors that directly bind to the BMI1 promoter region and regulate gene expression in nasopharyngeal carcinoma., C-myc in high-grade brainstem gliomas were significantly higher than that in low-grade brainstem gliomas and normal brain tissues and were positively, ING4 may regulate c-MYC translation by its association with AUF1., Findings support a model in which dysregulation of MYC by BRD-NUT fusion proteins has a central role in the pathogenesis of NMC., Simultaneous c-MYC and h-TERT deregulation is a relatively frequent event in colon adenocarcinoma., Data suggest epidermal growth factor induced the expression of c-MYC, which promoted the expression of mature miR-23a, miR-24-2, and miR-27a and subsequently decreased expression of Sprouty2 (SPRY2)., These results define a new link between two critical proteins in prostate cancer - AR and c-Myc., FOXO6 induces C-myc expression by associating to HNF4 and mediating histone acetylation, and the dissociation of HDAC3 from the promoter of the C-myc gene, High MYC expression was associated with shorter overall survival irrespectively of the International Prognostic Index., Pin1 and c-Myc are cooverexpressed in cancer, and this drives a gene expression pattern that is enriched in poor-outcome breast cancer subtypes., Expression of c-MYC and OGT was tightly correlated in human prostate cancer samples., conclude that chronic induction of c-myc especially in hepatocytes has the potential to prime resident HSC for activation, proliferation and myofibroblast differentiation, Data indicate that RPS14 negates c-Myc functions by directly inhibiting its transcriptional activity and mediating its mRNA degradation via miRNA., Study identified F-box protein, FBXO28 that controls MYC-dependent transcription by non-proteolytic ubiquitylation. Depletion of FBXO28 or overexpression of an F-box mutant unable to support MYC ubiquitylation results in an impairment of MYC-driven transcription, transformation and tumourigenesis., Missense FBXW7 mutations are prevalent in various tumors, including T cell acute lymphoblastic leukemia; study shows that these mutations specifically bolster cancer-initiating cell activity in collaboration with Notch1 oncogenes but spare normal hematopoietic stem cell function., Our results integrated TGF-beta1 signals to SKP2 via Akt1 and c-Myc during epithelial-mesenchymal transition., when an IGH-MYC dual-fusion probe was used, nine of 15 cases with a hybridization pattern suggestive of a non-IGH-MYC translocation were attributable to MYC copy gain rather than MYC rearrangement, LDH inhibition in Burkitt lymphoma cells led to decreased NAD cellular levels, which resulted in sirtuin-1 inhibition and MYC down-regulation., The study identifies enhanced proteasomal degradation and cathepsin-mediated proteolysis as important mechanisms for hypoxic MYC inhibition in human colon carcinoma cells., fundamental differences in miRNA expression exist between ocular adnexal EMZL and DLBCL, mainly due to differences in MYC and NF-kB regulatory pathways., The data demonstrate that the balance between c-Myc and Mnt activity determines the transcriptional outcome of the hTERT promoter by modulation of the chromatin architecture., Data indicate that patients negative for BRCA1 protein were more often with pathological tumor-node-metastasis stage III, positive for lymph node metastasis and MYC overexpression than BRCA1-positive tumors., Findings suggest that aluminum concentration does not affect genomic stability of ERBB2, C-MYC, and CCND1 genes in breast tissues., c-myc gene amplification is significantly correlated with disease-free survival and overall survival in patients with hepatocellular carcinoma after surgical resection and this model identifies patients with risk of early relapse., findings show that PDK1-PLK1-MYC signaling is critical for cancer cell growth and survival; PDK1-PLK1-MYC signaling induces an embryonic stem cell-like gene signature associated with aggressive tumor behaviors and is a robust signaling axis driving cancer stem cell self-renewal, Patients with family history of gastric cancer and H. pylori infection, with reversible histopathological changes of gastric mucosa, have higher levels of SATB1 and c-Myc gene expression as compared to patients without family history of gastric cancer., High MYC protein expression is associated with neuroblastoma of undifferentiated subtype., KPNA2 has an important role in promoting proliferation and tumorigenicity of epithelial ovarian carcinoma through upregulation of c-myc and suppression of FOXO3A., Data indicate that knockdown of any component of the novel mut-p53/c-Myc/Bcl-XL axis and complex reversed the oncogenic effects of PTEN., MicroRNA-145 function as a cell growth repressor by directly targeting c-Myc in human ovarian cancer., MYC immunohistochemistry score is an independent predictor of progression-free survival and overall survival in mantle cell lymphoma, Identification and analysis of the regulatory network of Myc and microRNAs from high-throughput experimental data., Our data suggest that targeting Myc in cancer therapy might have the additional benefit of inhibiting autophagy in the case of therapy resistance associated with chemotherapy-induced autophagy, Review, MYC protein expression alone is not significantly associated with differential benefit to concurrent trastuzumab, but potentially could help differentiate benefit between concurrent and sequential trastuzumab treatment., We show that, in contrast to PRC1, PRC2 is a tumor suppressor in Emicro-myc lymphomagenesis in lymphoma., These results establish a new signaling mechanism by which the interaction between YAP and c-Myc promotes liver cancer growth., co-overexpression of c-Myc and EZH2 in HCC samples was closely associated with lower expression of miR-101 (P < 0.0001) and poorer prognosis of hepatocellular carcinoma patients, Studies indicate that The oncogenic events leading to MYC up-regulation seem to overcome the inhibitory effect of physiological repressors such as BCL6 or BLIMP1., Levels of c-Myc were increased in intestinal epithelia of patients with active Crohn's disease compared with controls., There is a double-negative feedback loop between a tumor suppressor (miR-122) and an oncogene (c-Myc) in hepatocellular cancer., c-Myc is essential to prevent endothelial pro-inflammatory senescent phenotype., Case Report/Review, Gastric tumors showed MYC gene amplification and increased mRNA expression. Nuclear MYC protein staining was associated with intestinal-type gastric cancer., HER2 and MYC are frequently coamplified in breast cancer, associated with aggressive clinical behaviour and poor outcome., Myc targeting via RNAi-based transcriptional silencing can trigger cancer stem cells senescence and loss of their tumor-initiating capability., Demonstrate MYC amplification and MYC protein overexpression in a subset of primary cutaneous angiosarcomas., High c-myc expression is associated with myelodysplastic syndrome., The genes c-Myc, p21, and p16 were correlated with the prognosis of triple-negative breast cancer, Expression of CIP2A was found to be dependent on MAPK activity, linking elevated c-Myc expression to deregulated signal transduction in colon cancer, MYC translocation partner gene determines survival of patients with large B-cell lymphoma with MYC- or double-hit MYC/BCL2 translocations., mTORC2 promotes inactivating phosphorylation of class IIa histone deacetylases, which leads to the acetylation of FoxO1 and FoxO3, and this in turn releases c-Myc from a suppressive miR-34c-dependent network., c-Myc modulates genes associated with oncogenesis in glioblastoma multiforme through deregulation of miRNAs via the c-Myc-miR-26a-PTEN signaling pathway., Findings uncover a mechanism by which RPL5 and RPL11 can co-operatively suppress c-Myc expression, allowing a tightly controlled ribosome biogenesis in cells., A novel mechanism of c-Myc regulation., PDCD4 as tumor suppressor regulated miR-184-mediated direct targeting of BCL2 and C-MYC., The Myc-miR-17-92-BCR axis, frequently affected by genomic rearrangements, constitutes a novel lymphomagenic feed-forward loop., Androgen-induced AR activating signal upregulates let-7a that targets CMYC and KRAS and contributes to ER-, PR-, AR+ breast cancer pathogenesis., we investigated the effect of S(+)-ibuprofen on neuroblastoma cell lines, focusing on the expression of the MYCN, MYC, AKT, p53 proteins and the favorable neuroblastoma genes in vitro as biomarkers of malignancy, destabilization of MYC/MYCN by MIBG, metformin and phenformin and their effects on histone modification are important mechanisms underlying their anticancer effects, our data propose a novel mechanism to explain how E1a mediates radiosensitivity through the signaling axis E1a-->c-Myc--> replicative stress situation., Using in situ analyses of colorectal cancer specimens we demonstrated that c-MYC is a regulator of the identified target genes in human tumors thus implicating their relevance for tumorigenesis in humans., Study identifies SIRT7 as a cofactor of Myc for transcriptional repression and delineates a druggable regulatory branch of the ER stress response that prevents and reverts fatty liver disease., the lymphoma-stroma interaction in the lymphoma microenvironment directly impacts the biology of lymphoma through genetic and epigenetic regulation, with HDAC6 and c-Myc as potential therapeutic targets, Induction of sustained MYC expression in hypoxia contributes to activation of transcriptional programs critical for human embryonic stem cell self-renewal., Myc is central to T-ALL but its overexpression per se is inefficient in triggering the cascade of events leading to malignant transformation in T-cell acute lymphoblastic leukemia., Smad7 enhanced ubiquitylation of Myc through direct interaction with Myc and recruitment of Skp2. Ablation of Smad7 resulted in less sensitivity to the growth inhibitory effect of TGF-beta by inducing stable Myc expression., cyclophilin B (CypB) is a prolyl isomerase residing in the endoplasmic reticulum (ER), that provides an essential survival signal in glioblastoma multiforme cells through myc and mutant p53, MYC is involved in a wide range of cellular processes including cell-cycle control, metabolism, signal transduction, self-renewal, maintenance of pluripotency, and control of cell fate decisions., These findings suggest that nuclear AXIN2 functions as a rheostat to control MYC expression in response to Wnt/beta-catenin signaling., Cyclin dependent kinase-9 mediated transcriptional de-regulation of cMYC as a critical determinant of endocrine-therapy resistance in breast cancers., An association between increased 2-hydroxyglutarate levels and MYC pathway activation in breast cancer., ROCK has a crucial role in regulating prostate tumor growth through interaction with c-Myc, MYC gene alterations in large B-cell lymphomas are frequently associated with BCL2 or BCL6 translocations conferring a very aggressive behavior., In the current cohort, use of DISH identified all MYC amplified cases, and distinguished secondary angiosarcoma from AVL. DISH staining may be useful in distinguishing secondary angiosarcoma from AVL in challenging cases., We have also found out that CD44v8-10 expression is associated with the turn-over of the c-Myc with the experiments using gastric cancer cell lines., High c-myc expression was observed in glioma., Our results demonstrate that overexpression of miR-145 inhibits tumor growth in part by targeting c-Myc., these results highlight the tumor-suppressive role of SIRT4 in Myc-induced B cell lymphoma and suggest that SIRT4 may be a potential target against Myc-induced and/or glutamine-dependent cancers., meta-analysis suggests that the 8q24.21-rs6983267 polymorphism is associated with colorectal cancer (CRC) and colorectal adenoma susceptibility, but these associations vary in different ethnic populations, Inhibition of mRNA and protein expression of hTERT and c-myc., Findings suggest a model whereby ROCK inhibition drives polyploidization, DMS growth and proplatelet formation late in megakaryocyte maturation through downregulation of MYC and NFE2 expression., partial iPSCs depend on a high level of c-Myc expression for their self-renewal properties, Over-expression of HMGCR in esophageal squamous cell carcinoma (ESCC) cells promoted cell growth and migration., In conclusion, the development of colorectal cancer requires MYC activation through retention of the risk allele, or amplification of the non-risk allele at the oncogenic single nucleotide polymorphism., A critical role for c-Myc in leukemia-initiating cells maintenance and MYC inhibition may be an effective therapy for relapsed/induction failure T-cell acute lymphoblastic leukemia patients., Data suggest GHET1 (gastric carcinoma high expressed transcript 1) is prognostic factor for gastric carcinoma; GHET1 promotes c-Myc mRNA stability/expression, binds IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1), promotes tumor growth., Data suggest a shared underlying biology among proto-oncogene proteins myc rearranged B-cell lymphomas., Only 2 (3%) of 59 molecular Burkitt lymphoma lacked a MYC translocation, which both shared a peculiar pattern of chromosome 11q aberration characterized by interstitial gains including 11q23.2-q23.3 and telomeric losses of 11q24.1-qter., MYC-dependent breast cancer cells possess high MYC expression and high level of MYC phosphorylation, and are sensitive to inhibition of CDK1., Results show that Myc drives local prostate metastasis and is critical for maintenance of metastasis prostate cancer., c-MYC expression may have prognostic significance in synovial sarcoma., We conclude that MYC amplification is present in secondary mammary angiosarcomas but not in atypical vascular lesions, G-quadruplex forming DNA at c-Myc promoter Pu27 destabilizes proteins at telomere and inhibits DNA repair molecules., Study describes a novel mechanism, involving c-Myc and miR-17-92, which integrates cell proliferation and apoptosis resistance., EBP2 is a novel binding partner of c-Myc that regulates cell proliferation, and tumorigenesis via a positive feedback loop., the existence of different patterns of expression of Pim-3, c-Myc, and p-p27 and their clinicopathologic correlations in adenocarcinomas of the gastric cardia and the distal stomach., c-Myc over-expression may be a factor indicating poor prognosis in multiple myeloma., MYC, in concert with EZH2, epigenetically attenuates MST1 expression and suggest that the loss of MST1/Hippo functions is critical for the MYC or EZH2 mediation of cancer cell survival., Myc status alone can be used to predict overall survival in patients with colorectal cancer undergoing surgical resection., data suggest that MYC rearrangements, regardless of when they occur during multiple myeloma pathogenesis, provide one event that contributes to tumor autonomy, Suggest high level of c-Myc cytoplasmic expression may be considered as a valuable marker for prognosis of pancreatic cancer., conclude that downregulation of BIM represents a key survival signal downstream of oncogenic MYC and PI3K-AKT signaling in treatment-resistantT-cell acute lymphoblastic leukemia, We found no statistically significant relationship between the quantitative expression of c-myc and any other clinical or pathological parameters in oral squamous cell carcinoma, A second RIM/DS screen comparing lymphomas of wild-type and parental transgenics showed that CD2-MYC tumours are virtually dependent on activation of Runx family genes in strong preference to other potent Myc collaborating genes, c-Myc, which has been shown to induce rDNA transcription directly, is physically associated with rDNA gene looping structures and the intergenic spacer sequence in growing cells., It is a gastric carcinoma oncogene and is targeted by miR-494., silencing or loss of CDK4 augmented the tumorigenic potential of Myc-driven B cell lymphoma, Low specificity and positive predictive value (PPV) of MYC immunohistochemistry (IHC), in relation to fluorescence in situ hybridisation (FISH) analysis, were observed despite good sensitivity and negative predictive value (NPV)., Immunohistochemical assessment of p53, particularly in combination with MYC, could be useful in identifying a high-risk subgroup of patients with diffuse large B-cell lymphoma., MYC protein expression is a poor prognostic factor that may be associated with either B-cell lymphoma, unclassifiable or diffuse large B-cell lymphoma morphology, In human Colorectal cancer (CRC), gain-of-function alterations in Myc and loss-of-function alterations in TGF-beta exhibit a masking epistatic interaction and are functionally redundant., High expression of c-Myc/Ki-67 extranodal NK/T-cell lymphoma, nasal type patients may be valuable indicators for predicting survival., Myc and its obligate heterodimeric partner, Max, are integral to the coordinated recruitment and post-translational modification of components of the core transcriptional machinery., Data show loss of VHL, stabilization of HIF-2alpha and increased c-MYC activity, binding and transcriptional repression, through induction of PLA2R1 DNA methylation closed to PLA2R1 transcriptional start site, results in decreased PLA2R1 transcription., Amplification and overexpression of MYC is associated with the transition of cervical intraepithelial neoplasia to cervical cancer., A long noncoding RNA (lncRNA), CCAT1-L, is transcribed specifically in human colorectal cancers from a locus 515 kb upstream of MYC., c-myc regulated the expression of human PDF., This study provides for the first time, the c-Myc dependent regulation of NKG2D ligands in acute myeloid leukemia., TP53 mutations are frequent events in double-hit B-cell lymphomas with MYC and BCL2 but not MYC and BCL6 translocations, c-Myc-induced capping is required for c-Myc-dependent gene expression and cell proliferation, Significantly elevated c-MYC gene expression was found in cholesteatoma compared to atheroma and to normal skin samples., MYC-HEG and MXI1-LEG levels are associated with poor prognosis in patients with breast cancer, suggesting that they may be useful molecular markers in breast cancer prognosis prediction., Results demonstrated that SK2 regulates MYC, which has a pivotal role in hematologic malignancies., the knowledge of the Myc-dependent cell cycle regulatory mechanisms will help to discover new therapeutic approaches directed against malignancies with deregulated Myc, the c-Myc-mediated transcriptional repression of miR-15-16 in hypoxia is induced by increased HIF-2alpha and promoted tumor angiogenesis and hematogenous metastasis by the further loss of post-transcriptional inhibition of FGF2., Purified GCN5 binds to an N-terminal sub-domain of MYC TAD., MYC activation is a common event in plasma cell myeloma and could possibly represent a detectable transforming event from monoclonal gammopathy of undetermined significance to myeloma., Although neither Epstein Barr virus nor MYC are sufficient to cause Burkitt lymphoma there is increasing information from techniques such as complete RNA sequencing that identify essential pathways that are activated in the pathogenesis., The combinative model with IPI score and MYC protein expression could stratify DLBCL patients into prognostically relevant subgroups more effectively than either the IPI or the MYC alone., the expression and activity of c-MYC itself are under the control of miRNAs. Here, we survey how these networks mediate and regulate c-MYC functions., Here we review the activities of MYC, MNT and other MAX interacting proteins in the setting of T and B cell activation and oncogenesis, Here we will focus on how Myc controls a number of diverse cellular processes that converge to ensure processivity and robustness of DNA synthesis, thus preventing the inherent replicative stress responses usually evoked by oncogenic lesions., Studies indicate the prognostic value of C-MYC aberrations., MTBP associated with MYC at promoters and increased MYC-mediated transcription, proliferation, neoplastic transformation, and tumor development., MZF1-mediated MYC expression may promote tumor progression, resulting in poor outcomes in cases of lung adenocarcinoma with low-wild-type-LKB1 tumors., c-MYC gain (but not chromosome 8 gain or c-MYC amplification) is an independent poor-prognostic factor for survival in lung adenocarcinomas., The binding of Z-DNA binding domain of human ADAR1 to the G-quadruplex in c-Myc promoter resulted in repression of c-Myc expression., Kinesin-1 transports c-MYC for proteasomal degradation in the cytoplasm., These data demonstrate that ZFX functions as a critical upstream regulator of c-Myc and plays essential roles in the maintenance of the glioma stem cells phenotype, This is the first report describing the clinical characteristics of patients with MM and c-MYC. These abnormalities are associated with an aggressive form of MM, high incidence of PCL/EMD and short OS., MYC is part of a network of bHLHLZ proteins centered on the MYC heterodimeric partner MAX and its counterpart, the MAX-like protein MLX., Deletion of Long-range enhancers regulating Myc expression is associated with craniofacial development., Aspirin interacts with genetic polymorphism rs6983267 close to MYC in preventing colorectal cancer., Tumor suppressor DYRK1A effects on proliferation and chemoresistance of AML cells by downregulating c-Myc., Our study provides the first evidence that an miR-22/Sp1/c-Myc network regulates CD147 upregulation in breast cancer and that miR-22 represses breast cancer invasive and metastatic capacities., the decrease in the expression of miR-29b by c-Myc may be responsible for FHIT loss-mediated tumor aggressiveness and for poor outcome in non-small cell lung cancer., B-cell tumors harbored oncogenic c-myc amplification generated by breakage-fusion-bridge (BFB) from dicentric chromosomes formed through fusion of IgH V(D)J recombination-associated DSBs on chromosome 12 to sequences downstream of c-myc on chromosome 15., c-Myc contributes to the epigenetic regulation of HPP1 via the dominant recruitment of HDAC3., Our in vitro findings suggest that C-MYC and PVT1 oncogene (non-protein coding) copy number gains may promote a malignant malignant pleural mesothelioma phenotype., activation of PP2A (here accomplished through antagonizing endogenous inhibitors) could be a novel antitumor strategy to posttranslationally target c-MYC in breast cancer., Here, we discuss future research trends that embrace advances in genome-wide and proteome-wide approaches to systematically elucidate mechanisms of Myc action, we observed amplification of the MYC locus in 6/7 and MYC protein overexpression in all cases of undifferentiated round cell sarcomas defined molecularly by oncogenic fusion of the gene, CIC and DUX4 tested, A conserved Myc region (amino acids 186-203) is required for the interaction with Sin3 proteins. Histone deacetylase 1 is recruited to Myc-Sin3b complexes, and its deacetylase activity is required for the effects of Sin3b on Myc., these results suggest that HOTAIR is a c-Myc-activated driver of malignancy, which acts in part through repression of miRNA-130a., Results showed that E2F1 acts as a negative feedback regulator of c-Myc-induced hTERT transcription. If this negative regulating mechanism of E2F1 is attenuated or abrogated, hTERT is easily activated by c-Myc overexpression, leading to tumorigenesis., Results suggest that miR-155 is extensively involved in the cancer pathogenesis of gastric carcinoma and support its function as recessive cancer genes and show that c-myc is an important miR-155 target gene., High c-myc expression was observed in non-small cell lung cancers., Upregulation of MYC, KIT and RET and downregulation of CDKN2C characterise secondary angiosarcoma., These results suggest a relationship between the appearance of specific lipid species and the overexpression of MYC in lymphomas., Data identify a novel hotspot for mutations in MYC that deregulates its expression in lymphoma and strongly implies that MYC mutations have an active role in the pathophysiology of the disease., molecular basis for the anti-senescence effects of SIRT1 and FOXO3a, PIM inhibitors target CD25-positive AML cells through concomitant suppression of STAT5 activation and degradation of MYC oncogene., The mammalian MYC/MAX/MAD network is functionally conserved in Drosophila, MYC amplification is a frequent event in small cell lung cancer and is related to a short survival time., this is a preliminary study reporting, for the first time, a hypermethylated c-myc promoter in maternal plasma in preeclamptic pregnancies., miR-135b may play a role in the pathogenesis of osteosarcoma through regulation of c-myc expression., the frequency of detected cytogenetic aberrations MYC/MYCN, EGFR and PDGRFA, homozygous deletion of the CDKN2A gene, and deletion of the PTEN gene, pediatric glioblastomas bear analogy to the subgroup of IDH1-mutant glioblastomas in adults., Myc alone is insufficient to induce lymphoma and requires the Akt pathway., Nuclear expression of c-Myc was predominantly observed in oral carcinoma tissues., Here we give an overview of the role of MYC in regulation of metabolic pathways in tumor cells, PKM2 depletion could provoke glutamine metabolism by enhancing the beta-catenin signaling pathway and consequently promoting its downstream c-Myc-mediated glutamine metabolism in colon cancer cells., changes in MYC levels activate and repress specific sets of direct target genes that are characteristic of MYC-transformed tumour cells, Gain of PVT1 long non-coding RNA expression was required for high MYC protein levels in 8q24-amplified human cancer cells, p63 Regulates the migration and invasion of esophageal squamous carcinoma cells through activation of the beta-catenin/c-Myc pathway., PARP-1 is constitutively associated in vivo to a c-MYC promoter region recognized as biologically relevant for the transcriptional regulation of the gene., Data suggest that the combination of high p27 Kip1 and low Myc (c-Myc) is a marker of CLL cells which is mediated by Skp2 protein, indicate that c-Myc knockout cells preferentially utilize fatty acids as energy-generating substrates and reprogram other pathways to maximize acetyl-CoA and ATP production., There was no statistically significant association between c-myc expression and risk of relapse or death in our study. Routine c-myc immunostaining may help identify higher risk patients and guide management of B-ALL., The objective if the current review was to evaluate the implications of MYC aberrancy with respect to the B-cell lymphoma double-hit and triple-hit phenotypes and to consider the available data for clinical and practical management, the CRTC1/MAML2 transcriptional signature predicts other malignancies having combined involvement of MYC and CREB, Integration of proteomic and transcriptomic profiles identifies a novel PDGF-MYC network in human smooth muscle cells, high MYC/BCL2 DHS, high MYC/BCL6 DHS and high THS were associated with inferior OS and PFS in both CHOP and R-CHOP cohorts, a small subset of large B-cell lymphomas have concurrent MYC and BCL2 abnormalities other than translocations, c-myc is upregulated in hepatocellular carcinoma by PGE2., B-cell lymphomas with translocations involving MYC and BCL6 have morphologic and immunophenotypic features suggestive of Burkitt lymphoma or gray zone lymphoma, and they tend to be diagnosed mainly in women, often in extranodal locations., These results suggest that deregulation of MYC plays an important role in the pathogenesis of B-cell prolymphocytic leukemia and expands the spectrum of B-cell neoplasms associated with aberrations of MYC., show that physiologic upregulation of c-Myc can lead to cellular proliferation without DNA replication stress, c-Myc over-expression in leukemic cells induced resistance to chemotherapeutic drugs, enhanced colony formation capacity and inhibited cell differentiation induced by all-trans retinoic acid., Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis., C-myc, the downstream target gene of beta-catenin, plays an important role in regulating cisplatin resistance in A549/DDP cells., the high sensitivity of leukemia cells to HQ17(3) may be associated with the reduction of topo IIalpha and c-Myc activities, as well as with the downregulation of the miR-17-92 cluster expression., The studies demonstrated that c-Myc/Max functioned in maintaining chromatin-dependent repression of the hTERT gene in addition to activating its promoter., Our findings may be helpful in exploring the underlying mechanisms of CML and provide useful information in cancer treatment., MYC as a master regulator during hepatocarcinogenesis., PIWIL2 modulates tumor cell proliferation and F-actin filaments by interacting with NME2 and regulating c-Myc expression., identify a new long range-acting MYC enhancer controlled by NOTCH1 that is targeted by recurrent chromosomal duplications in T cell acute lymphoblastic leukemia, This study highlights that the gain of MYC and TP53 copies seems to be a frequent finding in gallbladder cancer., Data show that 2-deoxy-d-glucose (2-DG) combined with methylprednisolone synergistically inhibited cell proliferation, induced cell apoptosis and cell cycle arrest via down-regulation of hypoxia inducible factor 1 alpha subunit (HIF-1alpha) and c-MYC proten., S6K1 enhances c-Myc translation efficiency by modulating the phosphorylation of eukaryotic initiation factor eIF4B, which is critical to unwind its structured 5' untranslated region., Data suggest that Hhex is a novel regulator of c-Myc function that limits c-Myc activity in transformed cells., Immunoblastic variant of diffuse large B-cell lymphoma are genetically characterized by frequent MYC-IGH translocations., Hypofractionated radiotherapy enhances p53 gene transcription and protein expression, while c-Myc protein is downregulated., Transcriptional activation by MYC in colon cancer cells requires the continuous degradation of MIZ1., The poor prognostic marker, CD44, was among the upregulated genes. MYC translocations occurred as secondary abnormalities, present in subclones in one-half of the cases., JQ1 potently abrogates c-Myc expression in MCC cells., these results identify a c-MYC-related network that enhances SIRT1 protein expression in human FLT3-internal tandem duplication acute myeloid leukemia leukemia stem cells., A Myc-Aurka feedback loop., Data indicate that combined analyses of genetic aberrations and protein expression of neoplasm proteins MYC, BCL2 and TP53 identified a larger proportion of diffuse large B-cell lymphomas patients with poor outcome., USP37 is significantly upregulated in human lung cancer tissues, where its expression is positively correlated with c-Myc protein expression., a higher proportion of copy number alteration (CNA) at 8q24 (MYC loci) and the available evidence supporting the role of MYC in the processes cancer metastases is conflicting, MYC status was determined in tissue microarray sections, iM formation from a C-rich strand from the promoter of the human c-MYC gene., Data indicate that the rates of BCL6 gene rearrangement, P53 gene deletion and MYC rearrangement were 21.5% (14/65), 35.4% (23/65) and 7.7% (5/65), respectively., Report frequent MYC gains in T-cell prolymphocytic leukemia with cutaneous involvement., Intracellular NOTCH1 and NOTCH2, by inducing MYC, suppressed miR-30a in B- and T-cell malignancies., Importantly, the AKT1/MYC status was independent of Gleason grade and pathologic staging. Our findings show how prostate tumors undergo a metabolic reprogramming that reflects their molecular phenotypes, C-MYC overexpression may play an important role in aggressive transformation and is an independent prognostic factor in MALT lymphoma., anaplastic large cell lymphomas are dependent on IRF4 and MYC signaling, A distal enhancer at >1 Mb 3' of human Myc binds Notch transcription complexes and physically interacts with the Myc proximal promoter. Changes in Notch activation change H3K27 acetylation across the entire enhancer correlating with Myc expression., the ETV6/ARG oncoprotein contributes to autonomous cell growth by compensating for the requirement of growth factor through activating STAT5 signaling, which leads to the up-regulation of c-Myc., IGH/MYC and IGH/BCL2 double hit translocations are associated with plasma cell leukemia., GP130 signaling collaborated with MYC to induce MM and was responsible and sufficient for directing the plasma cell phenotype., STK33 plays an essential role in hepatocellular proliferation and liver tumorigenesis. STK33 may bind directly to c-Myc and increase its transcriptional activity., PCTK1 in the proliferation and survival of medulloblastoma characterized by cMYC amplification, MYC amplification by CISH was identified in 9% of SCLCs, and correlated with protein expression. As novel Myc-targeted therapies are developed, CISH and IHC should be considered as biomarkers of Myc pathway dysregulation in SCLC., The synergy of Aurora B inhibitor with cisplatin is dependent on c-Myc expression., Data indicate that proto-oncogene protein cMyc is required for PCAT-1-mediated cell proliferation., human cellular models with inducible expression of c-Myc and H-RasV12 (Ras), two commonly deregulated oncoproteins operating in a functionally connected signaling network, is reported., MYC loss-of-function alters multiple biological processes during adipogenesis., human dental pulp cells from deciduous and permanent teeth can undergo reprogramming to establish pluripotent stem cell lines without c-Myc, MSCs protected leukemia cells from apoptosis, at least in part, through c-Myc dependent mechanisms, and that c-Myc contributed to microenvironment-mediated drug resistance in AML., Putative novel MYC interactors include components of the STAGA/KAT5 and SWI/SNF chromatin remodeling complexes, Data indicate that dihydroindolizino indole derivative reduced c-MYC expression and brings down cancer cell proliferation in cancer cells., Multi-walled carbon nanotubes may act on c-Myc to down-regulate ABCB1/ABCC4 expression., Variable expression of MYC distinguishes Burkitt lymphoma from diffuse large B-cell lymphoma., Author demonstrate that both N-Myc and c-Myc proteins can bind and activate the TWIST1 promoter and propose TWIST1 as a direct MYC transcriptional target., The level of Myc binding at target genes and the transcriptional output are differentially modulated by additional regulators, including Miz1.[review], MYC expression and other immunophenotypic markers used for prognostication of systemic DLBCL might not apply to CNS DLBCL due to differences in disease biology., The data are consistent with the rs4487645-CDCA7L loci being responsible for the chromosome 7p11.2 association with multiple myeloma risk, probably exerting its effects through an extended pathway involving IRF4 and MYC., Overexpression of GYS1, MIF, and MYC is associated with adverse outcome and poor response to azacitidine in myelodysplastic syndromes and acute myeloid leukemia, the synthetic lethality between PRKDC and MYC may in part be due to PRKDC dependent modulation of MYC expression, as well as MYC-induced DNA damage where PRKDC plays a key role in DNA damage repair., By being a coactivator for both c-Myc and AR, PCGEM1 reprograms the androgen network and the central metabolism in a tumor-specific way, making it a promising target for therapeutic intervention., DEC2 participates in hypoxia-induced cell proliferation by functioning as a target gene of the PI3K/Akt signaling pathway and regulating the expression of c-Myc., Data show that p32 hyaluronan binding protein (p32) is a direct transcriptional target of oncogene Myc and that high level of Myc in malignant brain cancers correlates with high expression of p32., data identify c-MYC as a radiosensitive locus, implicating this oncogenic transcription factor in the aetiology of radiogenic breast cancer, Findings identify P53-MYC interactions at medulloblastoma relapse as biomarkers of clinically aggressive disease., Data indicate that proto-oncogene c-MYC is necessary and sufficient to confer resistance to everolimus., These findings indicate that the oncogenic function of c-Myc in prostate cancer cells is regulated by 5-Lox activity, revealing a novel mechanism of 5-Lox action, Results show that SORT1 and MYC SNPs were associated with incident coronary heart disease in African American individuals. We also provide evidence for fine-mapping at this locus, and identified an array wide association for a SNP in MYC., Data indicate that ribosomal protein (L11) promotes the recruitment of microRNA-130a (miR-130a) to oncoprotein c-Myc in response to UV irradiation treatment., CIP2A knockdown led to substantial reductions in c-Myc levels in PCa cell lines, but no significant change in phosphorylated Akt expression after CIP2A knockdown in DU-145 cells., c-MYC-acetylation is required for the cooperation between p30(II) and c-MYC which promotes proviral replication and contribute to HTLV-1-induced carcinogenesis., MYC protein expression is not necessarily correlated with MYC gene rearrangements in lymphomas., Data suggests a determinant role of additional, possibly differentiation-specific factors in the activity of MYC-bound lncRNA promoters., This study therefore implicates c-Myc as a potential regulator of the cancer-promoting effects of equol via up-regulation of eIF4GI and selective initiation of translation on mRNAs that utilize non-canonical initiation, including certain oncogenes, these results reveal c-MYC exerts suppressive effects at several critical checkpoints in Ag presentation, which contribute to the immunoevasive properties of B cell lymphomas, Results suggest that WT1 and c-MYC expression is important for survival in KRAS mutant tumors as opposed to KRAS wild-type non-small cell lung tumors., Elevated levels of c-Myc in the P493-6 cell model of Burkitt's lymphoma results in an increase of the total level of RNA., Boolean probability approaches identified MYC expression as potentially affecting liposarcoma signaling networks and cancer outcome. A large panel of lipomatous tumors revealed that MYC protein expression is correlated with patient survival., The suppression of c-Myc resulted in reduced cell growth, colony formation, and cell cycle progression in 5-8F nasopharyngeal carcinoma cells., Propose TPX2 and AURKA as novel co-regulators on the MYC pathway in colorectal neoplasms., let-7b decreases drug resistance in gastric cancer cells by downregulating c-Myc. Cancer stem cell differentiation involves double-negative autoregulatory loops (Lin28/let-7 and Myc/let-7) and a double-positive autoregulatory loop (Lin28/Lin28B/Myc)., our data showed that the depletion of CIP2A expression in PCa cell line DU-145 resulted in reduced c-MYC protein levels, Knockdown of MondoA, or its dimerization partner Mlx, blocks Myc-induced reprogramming of multiple metabolic pathways, resulting in apoptosis, These results indicate that a dynamic interplay of TCF transcription factors governs MYC gene expression in colorectal cancers., Findings suggest that the regulation of c-Myc in breast cancer cells is dependent on the molecular subtype, and that beta-catenin-mediated regulation of c-Myc and p21 may control the balance of cell death and proliferation in breast cancer., Results provide novel regulatory mechanisms in MYC function through lncRNAs and new potential lncRNA targets of colorectal cancer., Results establish that FBXW7 down-regulation is synthetic lethal with MYC, and that MYC is a critical target of FBXW7 in breast epithelial cells., Data show that tylophorine compounds exert anti-cancer activity predominantly by targeting and sequestering the caprin-1 protein and c-Myc mRNA associated ribonucleoprotein complex., Myc translocation is associated with lymphomagenesis., c-MYC expression is up-regulated through the cross-talk between ER and HER2 in aromatase inhibitor resistant breast cancer cells., c-MYC confers resistance to 5-fluorouracil through regulating ABCB5 expression in human colon cancer cells., Data indicate that long noncoding RNAs (lncRNAs) are a main component of the transcription factor c-Myc transcriptional network., INZ(c) treatment decreased c-Myc expression at both mRNA and protein level, and suppressed c-Myc transcriptional activity in human Burkitt's lymphoma Raji cells with mutant p53., Demonstrate regulation of global gene expression by MYC oncoprotein in liver stem cells to generate liver tumors., Data suggest that down-regulation of Myc expression may have beneficial effect on health and survival to old age. [REVIEW], Results suggest the potential for therapeutic application of Aurora kinase B inhibitors in the treatment of MYC overexpressing medulloblastoma., MYC+/BCL-2+ primary gastrointestinal diffuse large B-cell lymphoma patients have worse chemotherapy response and poorer prognosis than patients who only express one of the two proteins., These results suggest that low dose erlotinib-cisplatin combination exhibits its anti-tumor activity by targeting angiogenesis through the modulation of the c-MYC/HIF-1alpha/VEGF pathway in NSCLC with EGFR exon 19 deletions., Data indicate that high MYC protein levels abnormally delay resolution of DNA lesions., These findings provide new insights that SirT1 has a profound role in regulating RIBE where a c-Myc-dependent release of ROS may be involved., USP36 is a crucial and bono fide deubiquitinating enzyme controlling c-Myc's nucleolar degradation pathway, Comparative gene expression analysis suggested that a multitude of genes involved in the innate immune response were expressed in p19ARF wild-type, but not null, tumors upon MYC inactivation., We further uncovered that phosphoserine phosphatase (PSPH), the final rate-limiting enzyme of the SSP pathway, is critical for cMyc-driven cancer progression both in vitro and in vivo, Our results confirm MYC as frequently amplified in early-stage non-small cell lung cancer, the JQ1-resistant cells remain dependent on c-MYC that now becomes co-regulated by high levels of GLI2., luteolin and apigenin increased telomerase activity, maintained DPCs in a presenescent state, and activated the expression of Oct-4, Sox2, and c-Myc at a dose- and time-dependent pattern in DPCs even at late passages, albeit repressed differentiation, Data show that a small molecule inhibitor of the MYC transcription factor can be an effective anticancer agent when delivered using a integrin alphavbeta3 and VLA-4-targeted nanotherapy approach., Isolated MYC cytogenetic abnormalities in diffuse large B-cell lymphoma do not predict an adverse clinical outcome, Although immunohistochemical assessment for MYC and BCL2 may be a helpful initial screen to identify higher-risk patients, FISH analysis for MYC remains important for further risk stratification in patients with diffuse large B-cell lymphoma., Triple hit B-cell lymphoma with MYC, BCL2, and BCL6 translocations/rearrangements are clinically aggressive tumors associated with a poor prognosis., In the context of tyrosine kinase-activated leukemias, c-MYC contributes to aberrant DNA repair through downstream targets LIG3 and PARP1 up-regulation., Our data identify IL6 detection as a potential causal biomarker for MYC-driven metastasis after loss of PTEN and p53., c-myc may play an important role in antineoplastic drug sensitivity in melanoma., primary tumors were significantly more diffusely positive for c-myc than metastatic tumors (p = 0.011), Although MYC is a valuable ancillary tool in distinguishing angiosarcomas from atypical vascular lesions , FLT4 immunohistochemistry may be used to screen for patients with FLT4 gene amplification, data suggest that loss of the p53 tumor suppressor cooperates with Mychigh/TXNIPlow-driven metabolic dysregulation to drive the aggressive clinical behavior of TNBC., the mRNA of c-myc were increased by bile acids in acidified media but not at a pH of 7.0 . Importantly, pharmacologic inhibition of c-myc using 10058-F4 prevented hTERT induction by DCA or CDCA in gastric cancer cells under acidic conditions, We confirmed that these dimeric inhibitors directly bind to Myc blocking its interaction with Max and affect transcription of MYC dependent genes., a link between MYC and mTOR-independent eIF4E contribute to the resistance to everolimus in SCLC cells. Control of the MYC-eIF4E axis may be a novel therapeutic strategy for everolimus action in small cell lung cancer, This study provides some compelling evidences in support of HBx-elicited and c-Myc-mediated increase in UBF levels that abets oncogenic onslaught in hepatic cells by increasing rDNA transcription and ribosome biogenesis., ERK/MSK/Sp1/c-Myc axis functioned as a critical regulator of survivin expression., SCP1 regulates c-Myc stability and functions through dephosphorylating c-Myc Serine-62., Our findings show that MYC amplification is a highly specific but poorly sensitive marker for SAS and, therefore, a negative result does not exclude the diagnosis of angiosarcoma., c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4, high levels of Myc engage Miz1 in repressive DNA binding complexes and suppress an SRF-dependent transcriptional program that supports survival of epithelial cells., the expression of WNT4, a Wnt ligand, and three targets of Wnt-ss-catenin transcription activation, namely, MMP7, cyclinD1 (CD1) and c-MYC in 141 penile tissue cores from 101 unique samples, were investigated., expression of OCT4, SOX2, KLF4 and MYC (OSKM) induced pluripotent stem cell differentiation, Results show that Myc expression is up-regulated in esophageal squamous cell carcinoma and inversely correlates with mir-1294 expression. Also, in vitro studies show that MIR-1294 suppresses c-MYC expression by direct targeting its 3'UTR., Data suggest that ubiquitin thioesterase 7 (HAUSP) may act as an oncogenic protein that can modulate c-MYC protein expression via transformation-transcription domain-associated protein (TRRAP)., Here we show that an enhancer proximal to the c-Myc promoter is enriched in H3K27Ac and associated with high occupancy of BRD4, and coincides with a putative c-Myc super-enhancer in MCC cells., FBXO32 targets Lys-326 of c-Myc to form polyubiquitin chains, resulting in inhibition of cell proliferation., Demonstrate an association between nuclear C-MYC immunostaining and TMPRSS2-ERG status in prostate cancer., These data provide evidence for oncogenic properties of Scribble in Myc-driven B-cell lymphomagenesis, reinforcing recent findings that overexpression of a mutant form of Scribble can act as an oncogene in epithelial cells, a structural rationalization for the enhanced thermal stability of the MYC22-G14T/G23T G-quadruplex., Increased c-myc is associated with invasiveness in Non-small Cell Lung Cancer., Authors identified the MYC-repressed gene GADD45A as a target gene of the MYC-repressed MYCLos such as MYCLo-4 and MYCLo-6., high MYC protein expression was associated with lower overall survival in patients with primary diffuse large B-cell lymphoma of the central nervous system, DLBCL with BCL2 and c-MYC rearrangement of the subgroups of lymphoma is associated with very poor survival, MUC16 knockdown leads to inhibition of mTOR activity and reduced expression of its downstream target c-MYC, a key player in cellular growth, proliferation and metabolism., c-Myc protein functions in the process of DNA double-strand break repair, at least partially, through affecting the ATM phosphorylation and DNA-PKcs kinase activity., NF-kappaB2/p52, Is it only about MYC? How to approach the diagnosis of diffuse large B-cell lymphomas, the expression of SRC-1 was positively correlated with PCNA expression in human HCC specimens, and the expression levels of c-Myc in SRC-1-positive HCC specimens were higher than in SRC-1-negative, Essential for MYC expreession increase upon CDK9 inhibition is that the bromodomain protein BRD4 captures P-TEFb from 7SK snRNP to deliver to target genes and also enhances CDK9's activity and resistance to inhibition., Elevated levels of MYC in primary myeloma cells have been reported to arise from complex genetic aberrations and are more common than previously thought. Thus, elevated MYC expression is achieved differently in myeloma cell lines and primary cells., Triptolide may suppress HIF1alpha through a cMycdependent mechanism in pancreatic cancer., MYC is a key regulating factor for the control of ITGA1 expression in colorectal cancer., Findings indicate that IL7 receptor (IL7R) and c-myc expression as intrinsic biomarkers that can predict the fate of CD8+ T effector cells after adoptive transfer., SATB1 is overexpressed in pancreatic cancer, promoting cancer cell proliferation and invasion through the activation of MYC., protein pairs significantly correlated with an increased risk of death in non-small cell lung cancer, This review will focus on mechanisms that contribute to deregulation of MYC expression in pancreatic carcinogenesis and progression and will summarize novel biological findings from recent in vivo models. [review], The anti-PEL effects of IMiDs involved cereblon-dependent suppression of IRF4 and rapid degradation of IKZF1, but not IKZF3. Small hairpin RNA-mediated knockdown of MYC enhanced the cytotoxicity of IMiDs, Targeting Myc and let-7a may provide a selective mechanism for the deregulation of glucose metabolic pathways in glioma cells. (Review), Data indicate that diffuse large B-cell lymphoma (DLBCL) patients with proto-oncogene proteins MYC or BCL2 copy number aberration (CNA) constituted a unique group with extremely poor outcome and may require more aggressive treatment regimens., epigenetic regulation of key transcription factor MYC through LSD1 governs transitions between tumorigenic states and provides a framework for glioblastoma therapeutic development, HSP60 overexpression increases the protein levels of the p110alpha subunit of phosphoinositide 3-kinase and c-Myc, E2F1 transcripts and miR-17-5p were significantly downregulated while c-Myc and MxA transcripts were significantly upregulated in SLE., Data show that Myc sensitizes cancer cells to mitotic blockers and agents that accelerate mitotic progression by regulating the expression of an apoptotic network., Bag-1 indirectly affects cell survival through c-Myc activated signalling that causes elevation of ornithine decarboxylase, we describe a regulatory pathway modulating BCR and BCR/ABL1 expression, showing that the BCR promoter is under the transcriptional control of the MYC/MAX heterodimer., the epithelial expression of MYC was significantly enhanced in ectopic endometrium compared to eutopic tissues, required for formation of DOT1L-containing transcriptional active complex and recognition of DOT1L on epithelial-mesenchymal transition transcription factors in regulation of breast cancer stem cell activity, The amplification of c-MYC, MLL and RUNX1 genes is related to the progressive changes of the karyotype in patients with AML and MDS with trisomy 8, 11 and 21 in bone marrow, and is a part of the clonal evolution., The ADCY7 deficiency resulted in decreased cell growth, elevated apoptosis, and lower c-Myc expression in cultured leukemia cells obtained from acute myeloid leukemia patients., c-MYC protein levels were higher in cisplatin-resistant cells when compared with their cisplatin-sensitive counterparts., Tumor infiltrating neutrophils modulate AR/c-Myc signals to promote renal carcinoma cell proliferation., A dynamic alteration in TERT promoter occupancy by Snail and c-Myc is the mechanistic basis for TGF-beta-mediated regulation of TERT., In this review, we highlight recent progress in how these lncRNAs participate in control of MYC levels in normal and tumor cells., Case Reports, Case Report, Mechanistic studies indicated that PAF1C could promote lung cancer cell proliferation through regulating c-MYC transcription., The results do not support our hypothesis that common germline genetic variants in the MYC genes is associated with the risk of developing medulloblastoma., Immunohistochemistry for MYC testing in aggressive B-cell lymphomas can be used for screening cases, which require further confirmatory FISH testing., HPV[ human papillomavirus ] integration and c-MYC gene amplification detected by FISH could be an important biomarker for use in clinical practice to determine SIL [squamous intraepithelial lesions ] with a risk of progression., NDRG2 functions as an essential regulator in glycolysis and glutaminolysis via repression of c-Myc, and acts as a suppressor of carcinogenesis., Data show that proto-oncogene protein c-myc is upregulated by sumoylated heterogeneous nuclear ribonucleoprotein K (hnRNP K) at the translational level in Burkitt's lymphoma cells., Up-regulation of SIRT3 in prostate cancer suppressed the phosphorylation of Akt, leading to the ubiquitination and degradation of oncoprotein c-MYC., Data (including data from studies using transgenic mice) suggest that deregulated Myc pathway (due to weak IgH Calpha Myc allele) and the latency locus of KSHV (Kaposi sarcoma-associated herpesvirus) cooperate to further B-cell lymphoma progression., data suggest that oncogenic MYC confers a collateral stress on splicing, and so components of the spliceosome may be therapeutic entry points for aggressive MYC-driven cancers, MiR-34a suppresses trophoblast invasion by directly targeting MYC., Suppression of MYC and subsequent increase of PGC-1alpha were identified as key determinants for the OXPHOS dependency of CSCs, which was abolished in resistant CSC clones., Target gene recognition by MYC depends on its interaction with WDR5. This interaction could create an avidity-based chromatin recognition mechanism allowing MYC to select its target genes in response to both genetic and epigenetic determinants. Review., Loss of OTX2 expression resulted in decreased expression of C-MYC and CRX, genes previously implicated in retinoblastoma tumorigenesis. Loss of OTX2 expression increased the phosphorylation of RB, a potential mechanism of modulating cell proliferation, c-myc is involved in the formation of ovarian borderline mucinous cystadenoma and mucinous cystadenocarcinoma., SALL4 could induce Epithelial-mesenchymal transition and resistance to antineoplastic drugs through the regulation of c-Myc. SALL4 and c-Myc may be novel therapeutic targets for endometrial cancer., c-MYC Copy-Number Gain Is associated with Colorectal Cancer., High-grade B-cell lymphoma with MYC rearrangement and without BCL2/BCL6 rearrangements is associated with high P53 expression and a poor prognosis., MYC translocation-positive and MYC translocation-negative Burkitt lymphoma cases are slightly different in terms of microRNA and gene expression., Celastrol and some of its quinone methidecontaining analogs directly inhibit c-Myc-Max heterodimers in tumor cells., miR-342-3p is capable of indirectly regulating MYC activity via direct repression of E2F1., miR-320b suppresses cell proliferation by targeting c-Myc in human colorectal cancer cells, B-cell receptor stimulation promotes mRNA translation in chronic lymphocytic leukemia cells, including of the oncoprotein, MYC., The tryptophan metabolite picolinic acid suppresses proliferation and metabolic activity of CD4+ T cells and inhibits c-Myc activation., MicoRNA-451 is a novel tumor suppressor via targeting c-myc in head and neck squamous cell carcinomas, analysis of molecular interactions between c-Myc and various well known inflammatory mediators in Chronic Liver Diseases[review], C-MYC amplification in gastric cancer is correlated with survival in advanced stages and deeply invasive stomach cancer., Data confirmed the validity of the RC cell line as a representative model of proto-oncogene proteins MYC/BCL2 double-hit diffuse large B cell lymphoma., Data show that overexpression of c-myc proto-oncogene protein could prevent the metabolic shift induced by pituitary tumor-transforming gene (PTTG) knockwown., Data indicate an oncogenic role for an Ikaros protein/MYCBP2 protein/proto-oncogene protein c-MYC axis in adult acute lymphoblastic leukemia (ALL), providing a mechanism of target therapies that activate Ikaros in ALL., Data indicate that the presence of a myc proto-oncogene protein (MYC) but not bcl-2 proto-oncogene protein (BCL2) abnormality predicted the poor survival of MCL patients., SOX2 and SOX2-MYC Reprogramming Process of Fibroblasts to the Neural Stem Cells Compromised by Senescence., detected coordination between regulation of transcription and translation upon modulation of Myc activity and showed connection of these responses to mTOR signaling to enhance oncogenic transformation and to the TGFbeta pathway to modulate cell migration and invasiveness, Data show that combined MYC activation and Pten loss driven by the Hoxb13 regulatory locus synergize to induce genomic instability and aggressive prostate cancer that phenocopies the human disease at the histologic and genomic levels., study showed that De novo MYCyBCL2 double-hit BCP-ALL is a rare disease that also occurs in pediatric and young adult patients and associated with complex karyotypes and poor prognosis. Younger patients may benefit from intensified chemotherapy., Here, the authors report that the human adenovirus 5 E1A N-terminal region also interacted with the cellular proto-oncoprotein c-MYC and the homolog of enhancer of yellow 2 (ENY2)., Non-Hodgkin lymphomas with MYC+/BCL2+/BCL6- gene rearrangements was more likely to have a non-germinal center cell of origin than MYC+/BCL2-/BCL6+ and MYC+/BCL2+/BCL6+ lymphomas., inhibition of Ahnak can promote generation of induced pluripotent stem cells (iPSC) via up-regulation of endogenous c-Myc., The present meta-analysis suggests that the MYC rs9642880[T] allele is significantly associated with bladder cancer risk., Many exciting new small molecule inhibitors such as BCL-2 and MYC inhibitors are in development and are exciting for these diseases and attempts are underway to combine them with effective immunochemotherapy platforms., SerpinB3 indirectly increased the transcription of Myc through the induction of Yap pathway., Knockdown of c-Myc inhibited colon cancer cell proliferation largely through downregulating GCN5 transcription, which can be fully rescued by the ectopic GCN5 expression, IDO, through GCN2 kinase activation, downregulates the levels of TCRcomplex tchain and cMyc, resulting in the suppression of Tcell proliferation and a reduction in the levels of LDHA and GLS2, MYC-driven change in mitochondrial dynamics limits YAP/TAZ function in mammary epithelial cells and breast neoplasms., directed mutagenesis revealed the importance of c-Myc binding sites from -751 to -756 and -548 to -553 on the promoter of hPLSCR1in transcriptionally regulating the expression of hPLSCR1., Propose that degradation of MYC limits the accumulation of MYC/PAF1C complexes during transcriptional activation., single or combined genomic alterations and survival in diffuse large B-cell lymphomas, Results support a model in which the HBXIP/Hotair/LSD1 complex serves as a critical effector of c-Myc in activating transcription of its target genes, illuminating long-standing questions on how c-Myc drives carcinogenesis., Report MYC genetic alterations in angiosarcomas., Cd-induced accumulation of c-Myc requires the activation of several signaling pathways, Identify of MLL-fusion/MYC dash, verticalmiR-26 dash, verticalTET1 signaling circuit in MLL-rearranged acute myeloid leukemia., beta2-adrenergic receptor signaling promotes pancreatic ductal adenocarcinoma progression by facilitating PCBP2-dependent c-myc expression., Suggest that first line therapy for diffuse large B-cell lymphomas should be more specifically targeted against MYC and the genes and proteins that are deregulated by MYC., LMWHA/RHAMM downstream signaling regulates fibrosarcoma cell growth in a beta-catenin/c-myc dependent manner., when overexpressed, c-MYC is able to repress Per1 transactivation by BMAL1/CLOCK via targeting selective E-box sequences. Importantly, upon serum stimulation, MYC was detected in BMAL1 protein complexes, These findings demonstrate that MYC-overexpressing TNBC shows an increased bioenergetic reliance on fatty acid oxidation(FAO) and identify the inhibition of FAO as a potential therapeutic strategy for this subset of breast cancer., MYC appears to initiate and maintain tumorigenesis, in part, through the modulation of immune regulatory molecules., This work reveals a previously unrecognized function for ELL as an E3 ubiquitin ligase for c-Myc and a potential tumour suppressor., Alternative translation initiation from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site results in the production of two isoforms with distinct N-termini.,
OMIM_DISEASE Burkitt lymphoma,
SP_COMMENT disease:A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1., disease:Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors., function:Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes., online information:Myc entry, PTM:Phosphorylated by PRKDC., similarity:Contains 1 basic helix-loop-helix (bHLH) domain., subunit:Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B.,