Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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moesin(MSN) moesin(MSN) Related Genes Homo sapiens
CYTOBAND Xq11.2-q12,
GENERIF_SUMMARY amino-terminal domains of the ezrin, radixin, and moesin (ERM) proteins bind advanced glycation end products and have a role in diabetes, PECAM-1 co-localized with moesin at the cell periphery and in filopodia of glass-activated platelets; moesin may play a role in platelet adhesion, linking PECAM-1 with the actin cytoskeleton, moesin has a role in lymph node metastasis of oral squamous cell carcinoma, important role in lipopolysaccharide-induced TNF-alpha production, particularly in lipopolysaccharide-mediated signal transduction, ezrin/radixin/moesin proteins are recruited by NHE1 Na+/H+ exchanger and have roles in regulating Akt-dependent cell survival, All three ERM family members can localise to the nucleus; a specific nuclear localisation sequence, which is conserved and functional in all ERM family members, is identified, implying specific regulated nuclear import., there is nucleotide variation at Msn and Alas2 on the X chromosome, results suggest that ezrin-radixin-moesin proteins are required for microvillar positioning of L-selectin and that this is important both for leukocyte tethering and L-selectin shedding, Ezrin, radixin and moesin are ADP-ribosylated by Pseudomonas aeruginosa ExoS, Expression of ExoS in HeLa cells led to a loss of phosphorylation of Ezrin/radixin/moesin proteins that was dependent upon the expression of ADP-ribosyltransferase activity., early phagosome maturation was shown to depend on activation of Rho acting through Rho kinase on ezrin-radixin-moesin proteins, B-cell response to moesin, possibly derived from hematopoietic cells, frequently occurs in patients with acquired aplastic anemia, moesin negatively regulates stable microtubule networks and is a natural determinant of cellular sensitivity to retroviral infection, increased CD44, ezrin, radixin, and moesin phosphorylation represents a key molecular abnormality that guides T cell adhesion and migration in SLE patients., MSN was differentially expressed in sclerotic hippocampi compared to non-sclerotic ones., Moesin protein expression is a basal marker in breast tumors. Moesin expression was nearly an independent prognostic marker of poor outcome, the ezrin, radixin, and moesin proteins function as positive regulators of infection by X4-tropic HIV-1, Phosphorylation of ezrin/moesin by ROCK is involved in the early steps of apoptotic signaling following Fas receptor triggering and regulates apoptosis induction in Jurkat cells., functional alterations of moesin may be involved in pathological disorders associated with clathrin-mediated internalization or receptor recycling, Results suggest that activated moesin promotes F-actin redistribution and CD4-CXCR4 clustering and is also required for efficient X4-tropic HIV-1 infection in permissive lymphocytes., No aspects of T cell receptor signaling uniquely require transgenic ezrin or moesin; instead, T cell activation appears to depend on net ezrin, radixin, and moesin (ERM) protein expression, while ezrin and moesin function together., In Vitro and in Vivo Characterization of Molecular Interactions between Calmodulin, Ezrin/Radixin/Moesin, and L-selectin, c14orf166 was identified asa novel metastasis-associated protein, and the roles of radixin, moesin and c14orf166 in pancreatic cancer metastasis deserve further investigations., These studies identify a new ERM kinase of importance in lymphocytes and confirm the role of ezrin-radixin-moesin phosphorylation in regulating cell shape and motility., Moesin is a phenotypic marker for anaplastic carcinoma., expression of moesin delays senescence of human dermal microvascular endothelial cells, Moesin is crucial for invasion by melanoma cells in 3D matrices and in early lung colonization., Data show that stimulation of the NK cell-expressed tetraspanin CD81 induces phosphorylation of ezrin/radixin/moesin proteins and leads to NK cell polarization thereby facilitating NK cell migration toward various chemokines/cytokines., Ezrin, radixin, and moesin proteins are physiological substrates of the kinase activity of leucine-rich repeat kinase 2 (LRRK2)., Data show that TNF-alpha induces the formation of fibrotic foci by cultured retinal pigment epithelial cells through activation of transforming growth factor-TGF-beta signaling in a manner dependent on hyaluronan-CD44-moesin interaction., Findings suggest that there is a functional association between moesin expression and cellular senescence., Results suggest that VEGF-C promoted cervical cancer metastasis by upregulation and activation of moesin protein through RhoA/ROCK-2 pathway., important role in the innate immune response and toll-like receptor 4-mediated pattern recognition in periodontal disease, Results demonstrate a new regulatory mechanism of ezrin-radixin-moesin phosphorylation by sphingolipids with opposing actions of ceramide and sphingosine 1-phosphate., Data suggest that ezrin-radixin-moesin proteins are involved in the spatial regulation of Epac1 and cooperate with cAMP- and Rap-mediated signaling to regulate adhesion to the extracellular matrix., This study provides the novel evidence that increased phosphorylation of Ezrin/radixin/moesin proteins may contribute to proliferation of rheumatoid fibroblast-like synoviocytes., Dysregulation of the ezrin/radixin/moesin-RAGE complex might be an important step in rearrangement of the actin cytoskeleton during proinflammatory cytokine-induced epithelial-mesenchymal transition of human alveolar epithelial cells., ezrin, radixin and moesin play similar roles in the tumor cell metastatic potential and their roles of upregulating the expression of E-cadherin may be important in tumor progression, Knockdown of ERM family member moesin in host cells increases HIV type 1 replication., PDZD8 is a novel moesin-interacting protein that suppresses infection by herpes simplex virus type 1., Ezrin, radixin, and moesin are phosphorylated in response to 2-methoxyestradiol and modulate endothelial hyperpermeability., Knockdown of moesin did not influence the expression or function of P-gp, the ezrin, radixin and moesin proteins differentially modulate sphingosine 1 phosphate-induced alterations in lung endoethlial cell cytoskeleton and permeability, increased moesin expression promotes EMT by regulating adhesion and contractile elements for changes in actin filament organization., Both moesin and KRT17 demonstrated a tendency of increased expression as pT stage advanced., The ERM (ezrin, radixin, moesin) proteins are novel scaffolds at the level of SOS activity control, which is relevant for both normal Ras function and dysfunction known to occur in several human cancers., The up-regulation of Ezrin and Moesin and the down-regulation of E-Cadherin were associated with the invasion and metastasis of papillary thyroid carcinoma., Results confirm the involvement of RhoA/ROCK pathway and subsequent moesin Thr558 phosphorylation in advanced glycation endproduct-mediated endothelial dysfunction., MSN was regulated by tumor suppressive miR-133a and contributed to HNSCC oncogenesis., role of CCM3 and ezrin/radixin/moesin family of proteins in cell's response to oxidative stress, Activation of moesin, a protein that links actin cytoskeleton to the plasma membrane, occurs by phosphatidylinositol 4,5-bisphosphate (PIP2) binding sequentially to two sites and releasing an autoinhibitory linker., These results offer biological evidence of moesin as an EMT marker, support the association between moesin, Snail and EMT and suggest a role for moesin in breast cancer prognostication., Ano1, ezrin, and moesin/radixin colocalize apically in salivary gland epithelial cells, and overexpression of moesin and Ano1 in HEK cells alters the subcellular localization of both proteins, Ezrin/radixin/moesin are required for the purinergic P2X7 receptor (P2X7R)-dependent processing of the amyloid precursor protein., Control of adipogenesis by ezrin, radixin and moesin-dependent biomechanics remodeling., Moesin is a glioma progression marker that induces proliferation and Wnt/beta-catenin pathway activation via interaction with CD44., These results suggest moesin protein involved in the genesis and progression of astrocytomas, Data suggest that P-glycoprotein associate with the F-actin cytoskeleton through ezrin/radixin/moesin (ERM) in CCR9/CCL25 induced multidrug resistance of acute T-lymphocytic leukemia (T-ALL) cells., The aim of this study was to examine the expression of ERM (ezrin, moesin) and Rho (RhoA, RhoB and Cdc42) proteins in breast cancer (BC) patients., important role of ezrin-moesin-radixin proteins during HCV infection at the postentry level and highlight possible novel targets for HCV treatment., ERM proteins play important differential roles in the thrombin-induced modulation of EC permeability, with moesin promoting barrier dysfunction and radixin opposing it., Molecular basis for the moesin/l-selectin/CaM ternary complex; an important role for phospholipids in modulating l-selectin function and shedding., Moesin expression and CD44 expression might be useful markers of poor prognosis in gastric adenocarcinoma., Moesin was shown to be directly targeted by miR-200b; in breast cancer cell lines and patient samples, its expression is inversely correlated with miR-200 expression, and high levels of moesin were associated with poor relapse-free survival., Testosterone induces actin cytoskeleton remodeling by regulating ROCK-2/moesin expression and activation., Phosphorylation of moesin at Thr558 by JNK is important for podosome rosette formation., present findings suggest that moesin is characteristically overexpressed and activated in adenomyosis, and that moesin activation may be related to extension of adenomyosis in the myometrium., VIP regulates CFTR membrane expression and function in Calu-3 cells by increasing its interaction with NHERF1 and P-ERM in a VPAC1- and PKCepsilon-dependent manner., Talin has a role in regulating moesin-NHE-1 recruitment to invadopodia in breast cancer, STIP1 and moesin may be novel and differential sero-diagnostic markers for psoriasis vulgaris and psoriatic arthritis, Ezrin, radixin and moesin are unlikely targets for autoantibodies in demyelinating neuropathies., Ezrin and moesin expression is related to LSCC invasion and metastasis, and may be important molecular markers for predicting prognosis and therapeutic targets in LSCC patients, Moesin might be involved in renal fibrosis and its effects could be related to interacting with E-Cadherin., Data show that silencing ezrin-radixin-moesin (ERM) protein expression ablates deleted in colorectal carcinoma protein (DCC)-protein kinase A (PKA) interaction and specifically blocks netrin-induced PKA activity and phosphorylation., both moesin-mediated inhibition and its localized deactivation by myosin phosphatase are essential for neutrophil polarization and effective neutrophil tracking of pathogens., Moesin was required in HMGB1-induced F-actin rearrangement, hyperpermeability, and inflammatory responses. HMGB1 increased Thr558 phosphorylation of moesin. Moesin was elevated in sepsis., results indicate Moesin may regulate cell motility through its interactions with MT1-MMP and E-cadherin/p120-catenin adhesion complex and cytoplasmic expression of Moesin correlates with nodal metastasis and poor prognosis of OSCCs, Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion., Phospho-Ezrin/Radixin/Moesin (ERM) inhibit cell adhesion, and therefore, dephosphorylation of ERM proteins is essential for cell adhesion.Phospho-ERM induce formation and/or maintenance of spherical cell shape.,
SP_COMMENT function:Probably involved in connections of major cytoskeletal structures to the plasma membrane., PTM:Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures., similarity:Contains 1 FERM domain., subcellular location:Phosphorylated form is enriched in microvilli-like structures at apical membrane., subunit:In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation (By similarity). Binds SLC9A3R1., tissue specificity:In all tissues and cultured cells studied.,